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chr12:48,605,088-50,364,707

Best TWAS P=3.5e-17 · Best GWAS P=7.44e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RHEBL1	0.03	0.01	blup	315	0.02	4.4e-03	-6.5	-5.7	1.0e-08	0.69	0.07	0.72	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TUBA1A	0.08	0.06	lasso	4	0.06	1.8e-07	-5.6	5.5	2.8e-08	-0.62	0.99	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TUBA1B	0.08	0.06	lasso	7	0.06	4.6e-08	-5.2	5.3	9.0e-08	-0.57	0.96	0.03	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TUBA1C	0.41	0.54	lasso	5	0.54	3.0e-77	-5.4	-5.4	6.3e-08	0.62	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	LMBR1L	0.12	0.09	lasso	6	0.08	1.9e-07	-5.5	6.3	2.9e-10	-0.65	0.74	0.24	FALSE
6	GTEx	Adipose Visceral Omentum	LMBR1L	0.09	0.03	lasso	6	0.01	7.4e-02	-4.8	5.1	3.1e-07	-0.61	0.05	0.79	FALSE
7	GTEx	Adrenal Gland	CCDC65	0.13	0.00	enet	26	0.01	1.8e-01	4.2	-5.2	1.7e-07	0.35	0.13	0.26	FALSE
8	GTEx	Artery Aorta	CCDC65	0.19	0.08	enet	7	0.11	1.9e-06	-3.8	-5.3	1.3e-07	0.45	0.96	0.01	FALSE
9	GTEx	Artery Aorta	RP11-302B13.1	0.16	0.04	enet	13	0.08	2.9e-05	-3.7	5.2	1.9e-07	-0.52	0.21	0.51	FALSE
10	GTEx	Artery Aorta	RP11-302B13.5	0.13	0.07	lasso	6	0.06	2.0e-04	-5.3	6.5	1.1e-10	-0.64	0.17	0.52	FALSE
11	GTEx	Artery Tibial	CCDC65	0.14	0.08	enet	39	0.11	7.9e-09	-5.8	-6.2	4.9e-10	0.60	0.45	0.54	FALSE
12	GTEx	Artery Tibial	LMBR1L	0.07	0.04	enet	13	0.03	1.7e-03	-5.7	5.7	1.6e-08	-0.65	0.35	0.59	FALSE
13	GTEx	Brain Cerebellum	LMBR1L	0.18	0.15	lasso	1	0.12	1.9e-04	-5.5	5.5	2.9e-08	-0.63	0.10	0.66	FALSE
14	GTEx	Breast Mammary Tissue	LMBR1L	0.09	0.02	enet	19	0.01	5.5e-02	-5.5	6.1	9.8e-10	-0.72	0.04	0.79	FALSE
15	GTEx	Esophagus Mucosa	TUBA1B	0.08	0.02	enet	24	0.04	1.1e-03	-5.3	5.4	6.7e-08	-0.47	0.12	0.43	FALSE
16	GTEx	Esophagus Mucosa	LMBR1L	0.07	0.03	lasso	5	0.04	1.8e-03	-8.3	8.3	1.3e-16	-0.95	0.01	0.97	FALSE
17	GTEx	Esophagus Mucosa	RP11-386G11.10	0.10	0.02	enet	23	0.05	2.0e-04	-5.3	5.4	5.7e-08	-0.49	0.27	0.45	FALSE
18	GTEx	Esophagus Muscularis	TUBA1B	0.08	0.04	lasso	7	0.06	1.9e-04	-5.2	5.4	7.9e-08	-0.58	0.40	0.03	FALSE
19	GTEx	Esophagus Muscularis	RP11-386G11.10	0.10	0.11	lasso	7	0.10	1.0e-06	-5.2	5.3	8.7e-08	-0.58	0.89	0.01	FALSE
20	GTEx	Lung	LMBR1L	0.05	0.02	lasso	2	0.00	1.5e-01	-8.3	8.2	1.5e-16	-0.98	0.01	0.94	FALSE
21	GTEx	Muscle Skeletal	RP11-386G11.5	0.09	0.07	enet	17	0.08	7.4e-08	-7.7	7.6	3.4e-14	-0.84	0.05	0.95	FALSE
22	GTEx	Nerve Tibial	LMBR1L	0.08	0.04	lasso	4	0.06	3.1e-05	-7.9	7.6	2.4e-14	-0.86	0.05	0.94	FALSE
23	GTEx	Nerve Tibial	RP11-386G11.10	0.07	0.05	lasso	2	0.03	1.8e-03	-5.5	5.5	2.9e-08	-0.63	0.19	0.61	FALSE
24	GTEx	Ovary	RP11-302B13.5	0.25	0.04	enet	35	0.06	1.3e-02	-6.7	5.2	1.6e-07	-0.54	0.02	0.70	FALSE
25	GTEx	Pituitary	RP11-386G11.10	0.19	0.11	lasso	5	0.10	1.4e-03	-3.7	5.3	1.0e-07	-0.62	0.04	0.71	FALSE
26	GTEx	Skin Sun Exposed Lower leg	LMBR1L	0.15	0.10	lasso	3	0.09	3.1e-08	-5.5	5.6	2.1e-08	-0.63	1.00	0.00	FALSE
27	GTEx	Skin Sun Exposed Lower leg	RP11-386G11.10	0.08	0.00	enet	18	0.01	3.1e-02	-4.5	5.3	9.3e-08	-0.44	0.05	0.15	FALSE
28	GTEx	Spleen	LMBR1L	0.30	0.30	enet	11	0.30	2.4e-08	-4.8	6.6	3.5e-11	-0.60	0.47	0.30	FALSE
29	GTEx	Testis	TUBA1B	0.21	0.28	lasso	9	0.26	7.0e-12	-5.7	6.1	1.3e-09	-0.67	0.92	0.08	FALSE
30	GTEx	Testis	LMBR1L	0.13	0.11	lasso	3	0.12	4.1e-06	-5.3	5.3	9.0e-08	-0.62	0.67	0.19	FALSE
31	GTEx	Testis	PRKAG1	0.17	0.11	lasso	5	0.09	1.2e-04	-8.3	8.4	3.5e-17	-0.96	0.01	0.99	TRUE
32	GTEx	Testis	RP11-386G11.10	0.25	0.33	lasso	9	0.32	1.3e-14	-5.7	5.8	5.4e-09	-0.64	0.99	0.01	FALSE
33	GTEx	Thyroid	LMBR1L	0.12	0.10	lasso	3	0.10	6.4e-08	-5.5	5.8	6.3e-09	-0.66	0.86	0.14	FALSE
34	METSIM	Adipose	LMBR1L	0.05	0.03	blup	303	0.03	5.2e-06	-5.5	7.2	5.8e-13	-0.70	0.99	0.00	FALSE
35	YFS	Blood	TUBA1B	0.02	0.02	lasso	8	0.02	2.7e-08	-5.2	-5.2	1.7e-07	0.56	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	TUBA1C	0.12	0.10	lasso	4	0.10	1.2e-11	-5.3	-5.3	1.1e-07	0.59	0.00	0.99	FALSE