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chr15:80,377,452-84,573,491

Best TWAS P=1.35e-65 · Best GWAS P=6.93e-85 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BTBD1	0.07	0.01	bslmm	356	0.04	1.7e-05	-3.37	-7.0	3.4e-12	-0.02	0.06	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	C15orf40	0.06	0.09	bslmm	326	0.10	6.4e-12	5.02	-6.1	1.3e-09	-0.09	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IL16	0.04	0.04	lasso	2	0.03	9.3e-05	13.57	13.5	1.9e-41	0.44	0.55	0.07	TRUE
4	CommonMind	Brain Pre-frontal Cortex	KIAA1199	0.06	0.04	bslmm	581	0.03	2.1e-04	0.51	-5.9	4.2e-09	-0.24	0.43	0.05	FALSE
5	GTEx	Adipose Subcutaneous	BTBD1	0.06	0.08	lasso	4	0.06	5.8e-06	5.40	-5.6	1.8e-08	-0.04	0.85	0.13	FALSE
6	GTEx	Adipose Subcutaneous	IL16	0.12	0.00	enet	19	0.01	5.2e-02	1.26	7.7	1.3e-14	0.40	0.08	0.70	TRUE
7	GTEx	Adipose Subcutaneous	RP11-761I4.4	0.11	0.00	lasso	11	0.01	3.7e-02	11.86	10.8	4.6e-27	0.54	0.35	0.38	FALSE
8	GTEx	Adipose Visceral Omentum	BTBD1	0.20	0.01	enet	24	0.06	5.1e-04	5.42	-5.4	6.2e-08	-0.03	0.24	0.37	FALSE
9	GTEx	Artery Aorta	HDGFRP3	0.12	0.12	lasso	8	0.11	1.2e-06	5.02	5.6	2.4e-08	0.10	0.86	0.14	FALSE
10	GTEx	Artery Aorta	RP11-382A20.2	0.08	0.05	lasso	4	0.07	1.3e-04	5.37	6.1	1.2e-09	0.08	0.40	0.57	FALSE
11	GTEx	Artery Coronary	AP3B2	0.19	0.08	lasso	5	0.15	1.0e-05	5.29	7.1	9.0e-13	0.03	0.18	0.14	FALSE
12	GTEx	Artery Tibial	BTBD1	0.10	0.09	lasso	3	0.08	6.0e-07	5.47	-5.6	1.7e-08	-0.03	0.98	0.01	FALSE
13	GTEx	Artery Tibial	CPEB1	0.08	0.02	enet	14	0.03	1.9e-03	4.15	5.8	8.0e-09	0.06	0.54	0.05	FALSE
14	GTEx	Brain Cerebellum	GOLGA6L9	0.32	0.00	enet	5	0.01	1.3e-01	-6.75	6.6	4.5e-11	0.09	0.01	0.73	FALSE
15	GTEx	Brain Cortex	BTBD1	0.33	0.13	lasso	5	0.22	7.9e-07	7.23	-6.8	1.5e-11	-0.07	0.15	0.30	FALSE
16	GTEx	Brain Frontal Cortex BA9	BTBD1	0.12	0.01	enet	19	0.02	8.4e-02	5.42	-8.0	1.2e-15	-0.06	0.06	0.57	TRUE
17	GTEx	Breast Mammary Tissue	BTBD1	0.11	0.04	lasso	4	0.04	5.2e-03	5.44	-5.2	1.9e-07	-0.06	0.34	0.12	FALSE
18	GTEx	Breast Mammary Tissue	C15orf40	0.16	0.04	lasso	7	0.06	3.6e-04	6.00	5.9	4.1e-09	0.06	0.34	0.03	FALSE
19	GTEx	Breast Mammary Tissue	RP11-152F13.7	0.11	0.12	lasso	6	0.11	2.7e-06	5.17	-5.7	1.6e-08	-0.05	0.14	0.85	FALSE
20	GTEx	Breast Mammary Tissue (Male)	WHAMM	0.07	0.00	lasso	2	0.03	6.8e-02	5.29	5.1	2.7e-07	0.01	0.03	0.07	FALSE
21	GTEx	Breast Mammary Tissue (Male)	RP11-152F13.7	0.21	0.16	lasso	6	0.17	8.3e-05	-3.43	-5.1	2.9e-07	-0.04	0.07	0.40	FALSE
22	GTEx	Breast Mammary Tissue (Female)	RP11-152F13.3	0.04	-0.01	enet	7	-0.01	7.9e-01	1.70	-5.2	2.1e-07	-0.05	0.02	0.40	FALSE
23	GTEx	Breast Mammary Tissue (Female)	RP11-152F13.7	0.08	0.03	lasso	4	0.03	5.0e-02	6.22	-5.3	1.5e-07	-0.02	0.03	0.18	FALSE
24	GTEx	Cells Transformed fibroblasts	EFTUD1	0.17	0.12	lasso	7	0.14	9.0e-11	5.36	5.5	3.1e-08	0.05	0.36	0.64	FALSE
25	GTEx	Cells Transformed fibroblasts	MEX3B	0.18	0.12	enet	18	0.10	3.0e-08	5.36	5.5	3.8e-08	0.03	0.12	0.88	FALSE
26	GTEx	Cells Transformed fibroblasts	RPS17	0.11	0.05	lasso	4	0.05	9.8e-05	-4.52	-5.2	2.3e-07	-0.05	0.19	0.12	FALSE
27	GTEx	Colon Sigmoid	RPS17	0.13	0.14	lasso	5	0.11	9.7e-05	-5.63	-5.5	5.0e-08	-0.06	0.06	0.84	FALSE
28	GTEx	Esophagus Mucosa	EFTUD1	0.09	0.06	enet	10	0.08	9.0e-06	5.59	5.4	5.8e-08	0.04	0.01	0.99	FALSE
29	GTEx	Esophagus Mucosa	HDGFRP3	0.20	0.12	lasso	8	0.09	2.3e-06	7.94	7.1	1.0e-12	0.06	0.24	0.76	FALSE
30	GTEx	Esophagus Mucosa	RP11-152F13.3	0.38	0.29	lasso	9	0.33	1.1e-22	5.36	-6.2	7.5e-10	-0.06	0.63	0.37	FALSE
31	GTEx	Esophagus Mucosa	RP11-152F13.7	0.41	0.32	enet	30	0.41	4.9e-29	5.17	-5.2	2.4e-07	-0.06	0.34	0.66	FALSE
32	GTEx	Heart Atrial Appendage	AP3B2	0.27	0.23	enet	10	0.26	7.6e-12	5.32	5.7	1.2e-08	0.05	1.00	0.00	FALSE
33	GTEx	Heart Left Ventricle	HOMER2	0.09	0.08	enet	10	0.06	3.9e-04	5.83	-6.6	4.9e-11	-0.07	0.42	0.54	FALSE
34	GTEx	Heart Left Ventricle	RP11-152F13.3	0.16	0.05	lasso	5	0.06	4.0e-04	5.54	-6.1	9.6e-10	-0.07	0.05	0.93	TRUE
35	GTEx	Lung	IL16	0.10	0.04	lasso	4	0.06	1.2e-05	5.30	7.7	1.9e-14	0.45	0.27	0.12	TRUE
36	GTEx	Lung	RP11-152F13.3	0.23	0.13	lasso	4	0.17	4.0e-13	-4.17	-5.8	6.9e-09	-0.05	0.74	0.26	FALSE
37	GTEx	Lung	RP11-152F13.7	0.24	0.10	lasso	8	0.14	8.5e-11	-4.45	-5.4	7.0e-08	-0.04	1.00	0.00	FALSE
38	GTEx	Lung	RP11-761I4.4	0.15	0.08	enet	14	0.07	6.2e-06	5.30	5.5	4.2e-08	0.35	0.41	0.28	FALSE
39	GTEx	Muscle Skeletal	AP3B2	0.13	0.08	enet	13	0.10	7.5e-10	4.50	6.4	1.4e-10	0.05	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	CPEB1	0.07	0.01	enet	10	0.04	4.4e-05	1.64	5.6	2.1e-08	-0.01	0.12	0.12	FALSE
41	GTEx	Nerve Tibial	BTBD1	0.16	0.20	lasso	7	0.20	2.5e-14	5.35	-5.6	1.7e-08	-0.05	1.00	0.00	FALSE
42	GTEx	Nerve Tibial	C15orf40	0.20	0.14	lasso	5	0.14	4.6e-10	5.42	5.2	1.6e-07	0.04	1.00	0.00	FALSE
43	GTEx	Nerve Tibial	CPEB1	0.09	0.04	lasso	3	0.05	3.0e-04	-4.39	6.3	3.5e-10	0.08	0.80	0.02	FALSE
44	GTEx	Pancreas	RP11-152F13.3	0.14	0.08	lasso	4	0.12	6.2e-06	4.62	-6.0	1.4e-09	-0.05	0.17	0.62	FALSE
45	GTEx	Prostate	RP11-761I4.4	0.29	-0.01	lasso	7	0.00	4.4e-01	0.25	6.7	2.9e-11	0.19	0.05	0.31	TRUE
46	GTEx	Skin Not Sun Exposed Suprapubic	AP3B2	0.45	0.41	lasso	6	0.42	1.2e-24	4.50	5.2	1.8e-07	0.04	1.00	0.00	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	STARD5	0.13	0.00	enet	16	0.03	8.0e-03	0.62	-9.7	2.1e-22	-0.44	0.08	0.70	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	RP11-152F13.3	0.32	0.14	enet	16	0.22	1.9e-12	5.17	-5.1	2.8e-07	-0.05	0.87	0.13	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RP11-152F13.7	0.25	0.16	lasso	7	0.24	1.9e-13	5.17	-5.4	6.0e-08	-0.04	0.62	0.38	FALSE
50	GTEx	Skin Sun Exposed Lower leg	STARD5	0.09	0.01	lasso	4	0.02	1.6e-02	11.36	-8.7	3.6e-18	-0.45	0.24	0.18	TRUE
51	GTEx	Skin Sun Exposed Lower leg	RP11-761I4.4	0.13	0.07	enet	43	0.02	5.7e-03	10.33	6.6	5.1e-11	0.47	0.53	0.12	FALSE
52	GTEx	Spleen	AP3B2	0.81	0.20	lasso	12	0.22	2.9e-06	4.50	5.1	2.9e-07	0.03	0.08	0.06	FALSE
53	GTEx	Stomach	AP3B2	0.36	0.23	enet	9	0.21	2.1e-10	4.50	5.4	7.6e-08	0.05	1.00	0.00	TRUE
54	GTEx	Testis	BTBD1	0.06	0.01	enet	8	0.04	1.1e-02	5.89	-7.0	3.2e-12	-0.07	0.08	0.53	FALSE
55	GTEx	Thyroid	GOLGA6L9	0.12	0.02	lasso	4	0.01	6.5e-02	6.11	6.2	7.5e-10	0.08	0.04	0.64	FALSE
56	GTEx	Thyroid	CPEB1	0.04	0.07	lasso	2	0.05	1.2e-04	-4.39	5.1	2.7e-07	0.05	0.60	0.02	FALSE
57	GTEx	Uterus	AP3B2	0.43	0.37	lasso	2	0.27	2.6e-06	5.77	5.8	6.9e-09	0.01	0.31	0.05	FALSE
58	GTEx	Whole Blood	AP3B2	0.06	0.04	enet	6	0.03	1.1e-03	5.77	5.3	1.2e-07	0.00	0.39	0.02	FALSE
59	METSIM	Adipose	AP3B2	0.19	0.21	enet	12	0.21	8.7e-31	5.32	5.2	2.3e-07	0.03	1.00	0.00	FALSE
60	METSIM	Adipose	BTBD1	0.04	0.05	enet	13	0.07	4.1e-10	5.54	-7.1	1.3e-12	-0.05	0.56	0.44	FALSE
61	METSIM	Adipose	C15orf26	0.05	0.00	blup	503	0.01	2.3e-03	-0.58	-5.2	1.7e-07	-0.20	0.18	0.03	TRUE
62	NTR	Blood	HDGFRP3	0.03	0.02	enet	7	0.02	2.2e-08	5.07	6.4	1.6e-10	0.01	0.98	0.02	FALSE
63	NTR	Blood	IL16	0.04	0.02	lasso	4	0.02	2.6e-06	7.04	7.2	6.7e-13	0.18	0.99	0.00	FALSE
64	NTR	Blood	STARD5	0.06	0.02	lasso	8	0.03	9.2e-10	7.04	8.9	6.7e-19	0.26	1.00	0.00	TRUE
65	YFS	Blood	HDGFRP3	0.13	0.15	lasso	10	0.19	4.0e-61	5.28	6.9	4.5e-12	0.02	1.00	0.00	TRUE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3B2	0.07	0.02	blup	54	0.03	1.3e-03	4.15	5.9	4.6e-09	0.05	0.07	0.20	TRUE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC80154	0.16	0.10	lasso	2	0.09	5.0e-08	5.54	-5.7	1.2e-08	-0.10	0.00	1.00	TRUE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3B2	0.02	0.03	lasso	3	0.03	1.9e-06	5.49	5.6	2.7e-08	0.04	0.68	0.24	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC80154	0.15	0.03	enet	8	0.05	3.0e-11	5.54	-5.2	1.5e-07	-0.08	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMC3	0.02	0.00	blup	69	0.01	3.5e-03	-2.86	7.9	3.6e-15	0.24	0.01	0.30	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	AP3B2	0.11	0.00	blup	54	0.07	1.2e-04	5.49	5.2	2.6e-07	0.03	0.07	0.22	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3B2	0.16	0.14	lasso	4	0.15	3.2e-16	5.32	5.2	2.0e-07	0.04	0.81	0.19	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP3B2	0.04	0.00	blup	54	0.01	9.6e-03	5.32	6.2	4.3e-10	0.06	0.02	0.23	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BTBD1	0.06	0.03	blup	48	0.05	7.0e-06	5.44	-6.1	1.1e-09	-0.08	0.01	0.98	TRUE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC80154	0.08	0.06	blup	8	0.06	1.5e-07	5.54	-5.8	6.4e-09	-0.09	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STARD5	0.06	0.03	lasso	2	0.03	5.6e-04	11.55	-10.7	1.0e-26	-0.51	0.09	0.04	TRUE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C15orf40	0.19	0.01	blup	39	0.04	1.5e-03	5.32	5.4	6.9e-08	-0.04	0.02	0.04	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP3B2	0.06	0.06	lasso	1	0.06	1.8e-07	5.50	5.5	3.9e-08	0.04	0.72	0.26	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC80154	0.09	0.06	lasso	3	0.06	1.4e-07	5.54	-5.8	8.6e-09	-0.10	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	STARD5	0.05	0.01	blup	68	0.02	6.2e-03	0.17	-6.2	4.2e-10	-0.33	0.08	0.06	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3B2	0.06	0.05	lasso	2	0.04	6.9e-06	5.50	5.5	5.1e-08	0.04	0.74	0.21	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC80154	0.08	0.03	lasso	2	0.04	3.6e-05	5.54	-6.0	2.3e-09	-0.09	0.00	0.99	FALSE
83	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC80154	0.17	0.08	lasso	2	0.13	4.0e-14	5.54	-6.0	2.7e-09	-0.09	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOLGA6L10	0.08	0.02	enet	7	0.05	3.0e-04	-3.53	-5.5	4.5e-08	-0.07	0.00	0.72	FALSE
85	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TM6SF1	0.10	0.00	blup	41	0.03	4.3e-03	5.07	-6.3	3.5e-10	-0.04	0.01	0.29	FALSE
86	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	IL16	0.14	0.08	enet	10	0.09	1.4e-04	12.69	9.1	1.2e-19	0.31	0.17	0.10	TRUE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM103A1	0.08	0.05	lasso	3	0.04	2.7e-05	6.00	5.8	7.7e-09	0.06	0.21	0.48	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	IL16	0.04	0.02	blup	101	0.01	1.1e-02	10.14	17.1	1.3e-65	0.72	0.06	0.68	TRUE
89	The Cancer Genome Atlas	Soft Tissue Sarcoma	AP3B2	0.13	0.10	lasso	1	0.09	7.3e-06	5.32	5.3	1.1e-07	0.05	0.51	0.30	FALSE
90	The Cancer Genome Atlas	Skin Cutaneous Melanoma	BTBD1	0.13	0.12	lasso	3	0.13	2.8e-04	8.45	-7.7	1.1e-14	-0.08	0.00	0.85	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	IL16	0.11	0.01	enet	10	0.03	2.6e-03	18.18	10.9	7.7e-28	0.58	0.01	0.90	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC80154	0.11	0.06	lasso	2	0.05	8.5e-05	5.54	-5.2	2.1e-07	-0.10	0.00	0.98	FALSE
93	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HOMER2	0.32	0.00	enet	19	0.08	8.0e-04	-5.18	-5.7	1.4e-08	-0.05	0.01	0.13	FALSE
94	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC80154	0.13	0.08	lasso	1	0.06	4.9e-03	5.54	-5.5	3.0e-08	-0.10	0.00	0.82	FALSE
95	The Cancer Genome Atlas	Testicular Germ Cell Tumors	STARD5	0.40	0.00	blup	67	0.12	7.5e-05	0.58	-8.2	1.7e-16	-0.52	0.01	0.31	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	BNC1	0.07	0.10	lasso	1	0.10	4.3e-10	7.10	-7.1	1.3e-12	-0.07	0.84	0.16	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	BTBD1	0.05	0.04	lasso	4	0.04	1.7e-04	5.02	-5.3	1.2e-07	-0.09	0.04	0.83	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	C15orf26	0.20	0.16	enet	19	0.19	1.7e-18	-4.92	-6.3	3.3e-10	-0.09	1.00	0.00	TRUE
99	The Cancer Genome Atlas	Thyroid Carcinoma	CPEB1	0.03	0.02	blup	55	0.01	3.2e-02	-4.79	5.5	3.5e-08	0.07	0.06	0.37	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	LOC80154	0.04	0.03	lasso	2	0.02	5.7e-03	5.54	-5.8	7.7e-09	-0.10	0.00	0.90	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	STARD5	0.04	0.00	blup	68	0.01	3.5e-02	0.75	-5.4	5.6e-08	-0.32	0.02	0.05	FALSE