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chr16:3,611,610-5,510,848

Best TWAS P=2.34e-10 · Best GWAS P=1.52e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DNAJA3	0.23	0.29	lasso	3	0.29	1.2e-35	-5.2	-5.3	1.2e-07	0.93	0.11	0.89	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TFAP4	0.05	0.02	bslmm	384	0.01	6.9e-03	-3.2	-5.2	2.3e-07	0.54	0.09	0.28	FALSE
3	GTEx	Adipose Subcutaneous	HMOX2	0.13	0.05	lasso	6	0.04	2.2e-04	-5.2	-5.7	1.6e-08	0.93	0.03	0.97	FALSE
4	GTEx	Adipose Subcutaneous	NMRAL1	0.31	0.33	lasso	4	0.35	9.0e-30	-6.0	-6.0	2.2e-09	0.98	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	NMRAL1	0.36	0.27	enet	20	0.27	3.7e-14	-5.8	-6.0	1.4e-09	0.91	0.01	0.99	FALSE
6	GTEx	Artery Aorta	NMRAL1	0.43	0.42	lasso	8	0.42	4.7e-25	-6.0	-6.0	2.1e-09	0.99	0.00	1.00	FALSE
7	GTEx	Artery Coronary	NMRAL1	0.40	0.34	lasso	5	0.34	3.5e-12	-5.8	-5.8	8.6e-09	0.95	0.01	0.99	FALSE
8	GTEx	Artery Tibial	CDIP1	0.14	0.14	lasso	3	0.16	1.0e-12	-5.5	5.4	6.6e-08	-0.93	0.03	0.97	FALSE
9	GTEx	Artery Tibial	NMRAL1	0.38	0.30	enet	15	0.36	1.2e-29	-6.0	-5.5	3.8e-08	0.94	0.00	1.00	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CDIP1	0.47	0.47	lasso	6	0.52	1.2e-15	-6.0	-5.2	1.5e-07	0.94	0.01	0.99	FALSE
11	GTEx	Brain Cerebellar Hemisphere	NMRAL1	0.62	0.66	lasso	3	0.68	2.2e-23	-6.0	-6.0	1.5e-09	1.00	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	CDIP1	0.47	0.54	lasso	7	0.52	8.3e-18	-6.0	-5.7	1.1e-08	0.99	0.00	1.00	FALSE
13	GTEx	Brain Cerebellum	NMRAL1	0.81	0.55	lasso	10	0.62	4.6e-23	-5.8	-5.5	3.2e-08	0.95	0.01	0.99	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	HMOX2	0.28	-0.01	lasso	5	-0.01	7.1e-01	-5.8	5.9	4.4e-09	-0.89	0.02	0.80	FALSE
15	GTEx	Breast Mammary Tissue	NMRAL1	0.17	0.18	lasso	2	0.15	5.2e-08	-6.0	-6.1	1.3e-09	1.00	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	NMRAL1	0.20	0.11	lasso	4	0.10	2.4e-03	-5.5	-5.9	4.0e-09	0.98	0.01	0.92	FALSE
17	GTEx	Breast Mammary Tissue (Female)	NMRAL1	0.29	0.01	lasso	6	0.00	2.7e-01	-4.4	-6.1	1.2e-09	0.83	0.02	0.76	FALSE
18	GTEx	Cells Transformed fibroblasts	CDIP1	0.33	0.35	lasso	3	0.36	1.3e-28	-5.5	5.5	3.5e-08	-0.94	0.02	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	NMRAL1	0.15	0.12	lasso	5	0.12	1.6e-09	-6.0	-5.9	3.4e-09	0.98	0.00	1.00	FALSE
20	GTEx	Colon Sigmoid	CDIP1	0.25	0.04	lasso	6	0.04	1.6e-02	-3.9	5.4	6.4e-08	-0.88	0.02	0.78	FALSE
21	GTEx	Colon Sigmoid	NMRAL1	0.43	0.35	lasso	5	0.31	1.7e-11	-6.0	-6.0	1.7e-09	1.00	0.00	1.00	FALSE
22	GTEx	Colon Transverse	CDIP1	0.21	0.07	lasso	4	0.09	4.5e-05	-5.2	5.8	5.8e-09	-0.94	0.01	0.99	FALSE
23	GTEx	Colon Transverse	NMRAL1	0.38	0.19	enet	31	0.19	2.3e-09	-5.8	-5.2	2.3e-07	0.89	0.01	0.99	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	NMRAL1	0.47	0.28	lasso	4	0.26	4.3e-10	-5.8	-6.1	1.4e-09	0.92	0.01	0.99	FALSE
25	GTEx	Esophagus Mucosa	NMRAL1	0.23	0.13	lasso	4	0.12	2.7e-08	-5.5	-5.8	8.4e-09	0.95	0.01	0.99	FALSE
26	GTEx	Esophagus Muscularis	NMRAL1	0.30	0.35	enet	16	0.33	7.2e-21	-6.0	-6.3	2.3e-10	0.96	0.00	1.00	TRUE
27	GTEx	Heart Atrial Appendage	NMRAL1	0.27	0.25	lasso	2	0.23	1.1e-10	-6.0	-6.0	1.4e-09	1.00	0.00	1.00	FALSE
28	GTEx	Heart Left Ventricle	NMRAL1	0.36	0.26	enet	12	0.28	4.4e-15	-5.4	-5.5	3.7e-08	0.94	0.03	0.97	FALSE
29	GTEx	Lung	CDIP1	0.10	0.06	enet	13	0.08	1.5e-06	-5.2	5.8	5.3e-09	-0.83	0.01	0.98	FALSE
30	GTEx	Lung	NMRAL1	0.16	0.11	enet	3	0.13	3.4e-10	-6.0	-6.0	2.0e-09	0.99	0.00	1.00	FALSE
31	GTEx	Muscle Skeletal	CDIP1	0.07	0.07	lasso	2	0.06	6.1e-07	-5.8	5.8	7.7e-09	-0.94	0.01	0.99	FALSE
32	GTEx	Nerve Tibial	CDIP1	0.20	0.12	lasso	5	0.13	1.4e-09	-5.2	5.2	1.6e-07	-0.85	0.10	0.90	FALSE
33	GTEx	Nerve Tibial	NMRAL1	0.32	0.37	lasso	3	0.36	5.2e-27	-6.0	-6.0	1.5e-09	0.99	0.00	1.00	FALSE
34	GTEx	Ovary	NMRAL1	0.33	0.16	lasso	3	0.12	7.0e-04	-4.7	-5.4	7.8e-08	0.66	0.02	0.81	FALSE
35	GTEx	Pancreas	NMRAL1	0.31	0.12	enet	14	0.13	5.4e-06	-5.8	-5.8	6.6e-09	0.91	0.01	0.99	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	NMRAL1	0.19	0.12	lasso	3	0.11	1.3e-06	-5.8	-5.8	7.3e-09	0.94	0.00	1.00	FALSE
37	GTEx	Skin Sun Exposed Lower leg	CDIP1	0.08	0.06	lasso	3	0.05	6.8e-05	-5.5	5.8	6.3e-09	-0.94	0.01	0.99	FALSE
38	GTEx	Skin Sun Exposed Lower leg	NMRAL1	0.12	0.05	enet	9	0.04	1.6e-04	-4.8	-5.8	5.7e-09	0.89	0.01	0.99	FALSE
39	GTEx	Spleen	NMRAL1	0.35	0.20	lasso	6	0.23	1.6e-06	-5.8	-5.6	1.8e-08	0.84	0.02	0.86	FALSE
40	GTEx	Stomach	NMRAL1	0.16	0.18	lasso	1	0.16	6.5e-08	-5.8	-5.8	8.6e-09	0.93	0.01	0.99	FALSE
41	GTEx	Testis	NMRAL1	0.27	0.20	enet	6	0.22	2.4e-10	-5.5	-5.7	1.6e-08	0.95	0.00	1.00	FALSE
42	GTEx	Thyroid	CDIP1	0.15	0.14	lasso	3	0.15	1.5e-11	-4.7	5.3	9.1e-08	-0.94	0.02	0.98	FALSE
43	METSIM	Adipose	CDIP1	0.07	0.06	lasso	5	0.08	2.8e-12	-5.1	5.3	1.3e-07	-0.87	0.12	0.88	FALSE
44	METSIM	Adipose	NMRAL1	0.18	0.22	bslmm	447	0.22	8.8e-33	-5.8	-5.7	1.4e-08	0.95	0.01	0.99	FALSE
45	METSIM	Adipose	ZNF500	0.11	0.12	bslmm	393	0.11	1.0e-16	-3.8	-5.2	1.6e-07	0.48	0.99	0.01	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	CDIP1	0.13	0.18	lasso	2	0.17	3.6e-21	-5.8	-5.7	1.5e-08	0.94	0.01	0.99	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	NMRAL1	0.31	0.25	lasso	6	0.30	8.0e-40	-5.8	-5.6	1.9e-08	0.90	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf5	0.02	0.03	blup	37	0.03	9.7e-08	-5.8	6.2	6.3e-10	-0.96	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGRN1	0.03	0.00	blup	53	0.02	1.0e-04	-4.3	5.4	5.8e-08	-0.37	0.01	0.86	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf5	0.02	0.02	lasso	3	0.02	4.5e-03	-5.4	5.7	1.3e-08	-0.93	0.02	0.94	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf5	0.09	0.10	lasso	2	0.06	1.6e-04	-5.3	5.1	2.8e-07	-0.84	0.07	0.88	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMOX2	0.02	0.03	lasso	2	0.02	3.9e-03	-5.2	-5.4	5.9e-08	0.86	0.05	0.86	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMRAL1	0.17	0.20	enet	14	0.21	3.3e-23	-5.2	-5.5	3.3e-08	0.94	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf5	0.03	0.03	lasso	2	0.02	1.3e-03	-5.8	5.8	5.3e-09	-0.95	0.01	0.97	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf5	0.07	0.07	blup	37	0.07	1.1e-07	-5.8	6.1	1.3e-09	-0.94	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC342346	0.06	0.02	blup	34	0.02	1.2e-03	-5.5	6.3	3.2e-10	-0.90	0.00	0.99	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	MGRN1	0.04	0.00	blup	53	0.03	9.0e-04	-3.3	5.4	7.7e-08	-0.34	0.01	0.26	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf5	0.05	0.07	enet	4	0.07	1.1e-07	-5.2	5.5	4.6e-08	-0.88	0.08	0.92	FALSE