Hub : Genes

CDIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1367 0.0386 6.7e-07 0.140 NA 0.125 NA 0.162 4.2e-11 NA 5.2e-10 NA 1.0e-12
2 GTEx Brain Cerebellar Hemisphere 0.4670 0.0780 5.3e-11 0.472 NA 0.471 NA 0.522 8.8e-14 NA 9.4e-14 NA 1.2e-15
3 GTEx Brain Cerebellum 0.4720 0.0760 5.4e-12 0.540 NA 0.483 NA 0.519 9.1e-19 NA 3.4e-16 NA 8.3e-18
4 GTEx Cells EBV-transformed lymphocytes 0.1610 0.0620 2.9e-03 0.097 NA 0.016 NA 0.056 4.5e-04 NA 9.4e-02 NA 6.8e-03
5 GTEx Cells Transformed fibroblasts 0.3310 0.0510 0.0e+00 0.348 NA 0.320 NA 0.365 4.7e-27 NA 1.6e-24 NA 1.3e-28
6 GTEx Colon Sigmoid 0.2470 0.1050 5.2e-03 0.038 NA 0.029 NA 0.039 1.7e-02 NA 3.2e-02 NA 1.6e-02
7 GTEx Colon Transverse 0.2090 0.0680 9.0e-05 0.074 NA 0.061 NA 0.090 2.1e-04 NA 7.1e-04 NA 4.5e-05
8 GTEx Esophagus Gastroesophageal Junction 0.2460 0.0670 1.1e-06 0.237 NA 0.201 NA 0.253 4.6e-09 NA 8.6e-08 NA 1.2e-09
9 GTEx Esophagus Muscularis 0.3500 0.0640 3.5e-12 0.161 NA 0.193 NA 0.197 4.8e-10 NA 6.9e-12 NA 3.9e-12
10 GTEx Lung 0.1031 0.0324 4.2e-06 0.064 NA 0.077 NA 0.069 1.2e-05 NA 1.6e-06 NA 5.8e-06
11 GTEx Muscle Skeletal 0.0655 0.0288 3.0e-03 0.066 NA 0.057 NA 0.065 4.6e-07 NA 2.6e-06 NA 6.1e-07
12 GTEx Nerve Tibial 0.1988 0.0548 1.1e-06 0.121 NA 0.122 NA 0.132 7.2e-09 NA 5.9e-09 NA 1.4e-09
13 GTEx Skin Sun Exposed Lower leg 0.0840 0.0320 1.9e-03 0.062 NA 0.045 NA 0.049 7.8e-06 NA 1.3e-04 NA 6.8e-05
14 GTEx Thyroid 0.1510 0.0410 5.1e-07 0.136 NA 0.066 NA 0.150 1.5e-10 NA 8.9e-06 NA 1.5e-11
15 METSIM Adipose 0.0718 0.0193 2.2e-09 0.061 0.068 0.079 0.074 0.082 2.0e-09 1.8e-10 7.8e-12 3.5e-11 2.8e-12
16 ROSMAP Brain Pre-frontal Cortex 0.1295 0.0276 9.0e-15 0.177 0.134 0.154 0.159 0.169 3.6e-22 6.9e-17 2.9e-19 6.1e-20 3.6e-21

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.1 0.2 0.7 -0.3 -0.4 0.0 0.8 -0.5 0.2 -0.2 0.5 0.0 0.2 -0.8 0.0 -0.8 -0.1 0.0 0.5
Bipolar Disorder or Schizophrenia 3.8 9.2 10.5 -3.2 3.0 3.0 -2.9 -3.2 -3.2 -3.0 -3.2 -2.7 -2.8 -3.1 -2.7 -3.0 -3.1 -3.0 3.2
Depressed Affect (Nagel 2018) 0.6 1.2 2.8 -1.3 0.2 0.6 -0.6 -1.3 -0.9 -1.4 -1.0 -1.4 0.2 -1.2 -1.0 -1.2 -1.3 -1.7 1.2
Depression (Nagel 2018) 0.3 0.5 1.2 -0.9 0.2 0.3 -0.6 -0.9 -0.4 -0.7 -0.5 -0.8 -0.2 -0.9 -0.5 -0.9 -0.8 -1.1 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.5 6.1 1.9 -2.1 -2.1 2.2 1.9 2.0 2.5 1.9 1.8 0.1 1.5 1.7 1.4 2.0 2.1 -1.7
Neuroticism (Nagel 2018) 0.2 0.4 1.0 -0.9 -0.5 0.1 0.3 -0.8 -0.0 -0.7 -0.2 -0.9 1.0 -0.6 -0.6 -0.6 -0.9 -0.9 0.6
Schizophrenia (2018) 7.1 14.8 20.1 -3.9 4.2 3.9 -4.4 -3.8 -4.3 -3.6 -4.5 -3.5 -3.8 -3.3 -3.4 -3.2 -3.9 -3.9 3.8
Schizophrenia vs Biploar Disorder 2.2 2.8 8.0 -1.7 1.8 1.5 -2.2 -1.5 -1.8 -1.3 -2.2 -1.3 -2.8 -1.0 -1.2 -1.0 -1.7 -1.7 1.3
Worry (Nagel 2018) 0.2 0.5 1.0 -1.0 -0.0 0.2 -0.1 -0.9 -0.1 -0.4 -0.4 -0.6 -0.3 -0.8 -1.0 -0.9 -1.0 -0.7 0.7
Alzheimer’s Disease (in mother) 0.1 0.1 0.5 -0.2 0.5 0.7 -0.3 -0.1 -0.7 -0.4 -0.3 -0.2 -0.3 -0.3 -0.3 -0.1 -0.4 -0.4 0.3
Alzheimer’s Disease (in father) 1.5 1.6 3.0 1.4 -0.9 -0.8 1.0 1.5 1.3 0.9 1.2 0.9 1.1 1.6 1.2 1.7 1.3 1.4 -1.6
Alzheimer’s Disease (including proxy) 0.3 0.4 1.1 0.7 -0.2 -0.1 0.3 0.8 0.4 0.2 0.6 0.4 1.1 0.8 0.6 0.9 0.6 0.3 -0.8
Crohns Disease (2017) 0.7 1.6 3.2 -1.1 1.5 1.6 -1.1 -1.1 -1.1 -1.2 -0.8 -1.3 -1.8 -1.4 -1.0 -1.2 -1.1 -0.9 1.3
Irritable Bowel Disease (IBD) 0.4 1.0 2.8 -0.8 1.0 1.2 -0.6 -0.8 -0.9 -0.9 -0.6 -1.0 -1.7 -1.2 -1.0 -0.8 -0.9 -0.5 1.0
Ulcerative Colitis (UC) 0.0 0.1 0.2 -0.1 0.0 0.3 0.3 -0.1 -0.3 -0.1 -0.1 -0.3 -0.4 -0.3 -0.5 -0.1 -0.1 0.2 0.1
Major Depression (MDD) 0.8 1.0 1.7 -1.3 0.5 1.0 -0.3 -1.3 -1.0 -1.1 -0.9 -1.0 -1.0 -1.2 -0.4 -1.2 -1.2 -0.9 1.1
Reaction Time 2.4 4.7 7.3 -2.2 2.4 2.7 -1.7 -2.4 -1.4 -2.5 -1.7 -1.5 -1.5 -2.6 -1.8 -2.7 -2.1 -2.0 2.5
Verbal and Numeric Reasoning (VNR) 1.2 2.8 4.0 1.9 -1.5 -1.7 1.6 1.9 1.7 2.0 1.7 1.9 -0.3 1.5 1.7 1.4 2.0 1.8 -1.6
Breast Cancer 0.1 0.2 0.8 -0.3 0.3 0.1 -0.6 -0.3 -0.1 -0.5 -0.2 -0.7 -0.7 -0.1 -0.3 -0.2 -0.3 -0.9 0.1
Ovarian Cancer 0.1 0.1 0.5 0.3 -0.4 -0.3 0.3 0.4 -0.0 0.3 0.3 0.4 0.3 0.5 0.3 0.7 0.2 0.4 -0.5
Prostate Cancer 1.6 2.2 6.4 -1.3 1.1 1.2 -1.5 -1.1 -2.5 -1.6 -1.9 -2.0 0.5 -0.4 -1.9 -0.6 -1.4 -1.8 0.7
Age at First Birth 0.2 0.3 0.9 0.7 -0.3 -0.6 0.3 0.6 0.7 0.6 0.7 0.6 1.0 0.3 0.7 0.3 0.7 0.5 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 4.4 -1.3 1.0 1.3 -0.8 -1.4 -1.2 -1.3 -1.0 -1.3 -2.1 -1.0 -1.0 -1.4 -1.2 -1.0 1.0
Coronary Artery Disease (CAD) 0.0 0.0 0.1 0.0 -0.0 0.1 0.2 0.0 0.1 -0.0 0.1 0.2 -0.2 0.3 0.2 0.2 0.0 0.2 -0.2
Crohns Disease (2012) 0.6 0.9 1.7 -0.9 1.3 1.3 -0.8 -0.9 -0.7 -1.2 -0.4 -0.8 -1.1 -1.1 -0.2 -1.1 -0.9 -0.8 1.1
Mean Putamen Volume 1.6 1.8 3.1 1.6 -1.3 -1.6 1.1 1.5 1.1 1.8 1.4 1.3 0.9 1.2 1.0 1.3 1.6 1.5 -1.2
Fasting Glucose 5.0 5.9 8.2 -2.1 2.9 2.6 -2.8 -2.0 -2.8 -2.4 -2.5 -2.4 -2.0 -2.6 -2.5 -2.0 -2.3 -2.2 2.6
HbA1C 0.2 0.3 0.7 -0.1 0.7 0.9 -0.0 0.1 -0.7 -0.4 -0.5 -0.8 -0.2 -0.6 -0.3 0.1 -0.5 0.4 0.6
HDL Cholesterol 2.4 4.0 7.3 2.0 -2.0 -1.6 2.3 2.0 2.0 2.1 1.9 1.7 2.7 1.9 1.6 2.0 1.9 2.0 -1.9
LDL Cholesterol 1.0 1.6 2.2 1.3 -1.3 -1.3 1.5 1.3 1.0 1.3 1.1 0.9 0.1 1.4 1.5 1.3 1.3 1.5 -1.4
Lupus 0.7 1.0 2.2 1.0 -0.8 -0.9 1.2 0.9 1.1 1.0 1.1 0.9 0.5 0.9 1.5 0.8 1.0 1.3 -0.8
Neuroticism (2016) 0.1 0.1 0.3 -0.5 -0.6 -0.0 0.3 -0.4 -0.5 -0.2 -0.0 -0.1 0.6 -0.1 -0.3 -0.1 -0.5 -0.5 0.0
Primary Biliary Cirrhosis 1.3 1.8 3.1 -1.4 1.5 1.8 -1.0 -1.5 -1.4 -1.1 -1.3 -1.2 -1.1 -1.6 -0.7 -1.6 -1.5 -0.9 1.6
Rheumatoid Arthritis 1.1 1.5 2.5 1.2 -1.6 -1.3 1.5 1.2 1.3 1.0 1.3 1.2 0.5 1.3 0.9 1.2 1.3 1.1 -1.4
Schizophrenia (2014) 6.9 15.1 18.5 -4.0 3.9 3.9 -4.2 -3.8 -4.2 -3.7 -4.3 -3.8 -4.2 -3.4 -3.6 -3.3 -4.1 -4.0 3.8
Triglycerides 0.3 0.5 3.0 -0.7 0.6 0.5 -0.6 -0.7 -0.6 -0.9 -0.5 -0.5 -1.7 -0.6 -0.3 -0.8 -0.5 -0.5 0.7
Type 2 Diabetes (T2D) (2012) 1.6 1.8 2.6 -1.5 1.5 1.4 -1.6 -1.5 -1.4 -1.2 -1.2 -1.3 -0.6 -1.2 -1.0 -1.5 -1.4 -1.4 1.3
Ulcerative Colitis 0.2 0.3 0.7 -0.5 0.5 0.7 0.0 -0.6 -0.5 -0.3 -0.2 -0.2 -0.7 -0.7 -0.3 -0.9 -0.4 -0.1 0.6
Blood Eosinophil Count 4.0 30.8 34.8 -5.8 5.5 5.6 -5.5 -5.8 -5.5 -5.9 -5.9 -5.6 -3.6 -5.5 -5.6 -5.5 -5.8 -5.8 5.7
Blood Platelet Count 3.5 40.8 49.7 -6.4 7.0 6.6 -6.7 -6.4 -6.6 -6.1 -6.6 -5.7 -3.5 -6.8 -6.2 -6.6 -6.7 -6.4 7.0
Blood Red Count 0.0 0.2 1.0 0.2 -0.8 -0.6 1.0 0.2 0.3 -0.1 0.5 -0.3 -0.4 -0.3 -0.1 -0.1 0.3 0.5 0.1
Blood White Count 3.6 26.7 34.1 -5.1 5.7 5.5 -5.3 -5.2 -5.8 -5.2 -5.2 -4.9 -2.9 -5.2 -4.8 -5.3 -5.3 -5.0 5.5
Heel T-Score 2.7 21.3 30.0 -4.6 4.9 4.7 -4.7 -4.6 -4.2 -4.2 -4.5 -5.5 -4.5 -4.5 -4.2 -4.5 -4.8 -4.6 4.7
BMI 0.2 1.4 2.6 1.2 -1.6 -1.6 1.4 1.3 1.1 1.0 1.3 0.9 -1.5 0.8 0.2 1.1 1.4 0.9 -1.0
Height 0.2 3.8 10.0 1.5 -2.3 -2.1 3.0 1.4 2.2 1.8 2.5 1.8 -3.2 0.7 1.4 0.8 1.7 2.1 -1.2
Waist Hip Ratio (WHR) 15.9 71.7 85.5 -8.8 8.2 8.3 -8.7 -8.7 -7.8 -8.4 -8.8 -8.7 -8.3 -7.9 -8.2 -8.2 -8.9 -9.2 8.1
Systolic Blood Pressure 2.2 10.9 22.1 -2.8 4.5 3.6 -4.7 -2.8 -4.0 -3.2 -3.7 -2.6 0.7 -2.9 -3.4 -2.8 -3.1 -3.1 3.2
Smoking Status 0.1 0.1 0.9 0.1 -0.0 0.0 0.1 0.2 -0.1 -0.1 -0.1 -0.5 1.0 0.5 -0.0 0.5 -0.1 0.2 -0.4
Allergy or Eczema 0.3 0.7 1.6 0.7 -1.0 -0.5 1.2 0.8 0.8 0.7 0.5 0.4 1.0 0.9 0.9 1.0 0.6 0.9 -0.8
Cardiovascular Disease 1.6 5.2 11.6 -2.0 3.0 2.0 -3.4 -1.9 -2.7 -2.3 -2.5 -1.9 -0.0 -1.8 -2.5 -1.6 -2.2 -2.5 2.1
Hypothyroidism (self reported) 0.2 0.5 1.3 -0.7 0.7 0.9 -0.4 -0.8 -0.4 -1.1 -0.4 0.3 -0.3 -0.8 -0.7 -0.7 -0.7 -0.7 0.7
Respiratory disease 1.6 3.7 4.7 -1.9 1.8 2.1 -1.7 -1.9 -2.0 -2.1 -1.9 -1.9 -1.1 -2.0 -2.0 -1.9 -1.9 -2.2 1.9
Type 2 Diabetes (T2D) (2018) 0.9 1.7 2.5 -1.5 1.5 1.5 -1.1 -1.4 -1.6 -1.3 -1.2 -1.1 -0.9 -1.2 -0.7 -1.3 -1.6 -1.1 1.4
Lung FEV1/FVC ratio 3.8 19.2 24.2 4.5 -4.8 -4.9 4.4 4.6 4.7 4.6 4.1 3.7 3.6 4.1 4.2 4.5 4.5 4.5 -4.2
Lung FVC 4.2 21.5 28.5 -4.5 5.2 4.9 -5.3 -4.5 -4.8 -4.3 -4.6 -3.6 -5.2 -4.4 -4.2 -4.5 -4.6 -4.5 4.6
Neuroticism 1.0 2.5 4.2 -2.0 0.7 1.2 -0.9 -1.9 -1.2 -1.5 -1.3 -1.5 -0.5 -2.1 -1.5 -2.0 -1.9 -1.9 2.0
Chronotype (morning person) 1.0 2.4 5.6 1.4 -1.1 -1.1 1.6 1.4 1.8 1.6 1.7 1.2 2.4 1.2 1.8 1.3 1.4 2.0 -1.2
Hair Pigment 1.0 29.1 34.1 5.4 -5.2 -5.7 4.7 5.5 5.4 5.8 4.8 4.5 5.8 5.8 5.2 5.8 5.3 5.3 -5.7
Tanning 1.4 16.5 23.4 -3.8 4.8 4.3 -4.8 -3.9 -4.5 -4.0 -3.9 -3.2 -3.8 -4.1 -3.2 -4.0 -4.0 -4.0 4.4
Hand grip strength (left) 1.6 4.1 9.6 -2.1 1.6 1.8 -1.5 -2.2 -1.7 -2.1 -1.5 -1.8 -3.1 -2.2 -2.0 -2.4 -1.9 -2.0 2.0
Number of treatments/medications taken 0.1 0.2 2.0 0.2 0.0 -0.2 -0.0 0.4 0.0 0.3 0.2 0.6 1.4 0.4 0.5 0.5 0.1 0.4 -0.3
Average weekly spirits intake 2.7 3.4 4.9 -1.8 2.1 2.2 -1.7 -1.9 -1.4 -1.7 -1.7 -2.1 -1.8 -1.8 -1.5 -2.0 -1.9 -1.7 2.0
Sensitivity / hurt feelings 4.7 8.1 11.0 -3.1 2.1 2.5 -2.4 -3.0 -3.0 -3.2 -3.0 -3.3 -2.2 -2.6 -2.9 -2.6 -3.1 -3.3 2.6
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.2 -0.8 0.3 0.2 -0.5 -0.9 -0.6 -0.6 -0.3 -0.8 0.1 -1.0 -0.5 -1.1 -0.6 -0.9 1.0
Hearing difficulty/problems: Yes 0.2 0.3 0.9 -0.5 0.3 0.3 -0.6 -0.5 -1.0 -0.5 -0.6 -0.6 -0.1 -0.2 -0.6 -0.3 -0.5 -0.7 0.2
Relative age of first facial hair 0.6 1.2 2.2 -1.1 1.4 1.1 -1.3 -1.2 -1.0 -0.7 -1.2 -0.8 -0.2 -1.3 -1.1 -1.5 -1.1 -0.9 1.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 0.6 -0.6 -0.5 0.7 0.5 0.1 0.4 0.5 -0.4 0.7 0.4 0.5 0.3 0.6 0.6 -0.5
Ever used hormone-replacement therapy (HRT) 4.7 6.0 8.3 2.6 -2.4 -2.4 2.1 2.6 1.8 2.3 2.5 2.2 2.6 2.9 2.2 2.8 2.5 2.4 -2.8
Ever had hysterectomy (womb removed) 1.2 1.4 2.9 -0.9 1.7 1.6 -1.1 -1.0 -1.3 -0.8 -1.1 -0.8 -1.4 -1.2 -0.7 -1.1 -1.1 -0.5 1.4
Systolic blood pressure, automated reading 1.3 3.7 10.8 -1.5 2.9 2.0 -3.3 -1.4 -2.6 -1.7 -2.3 -0.9 0.1 -1.5 -2.0 -1.3 -1.7 -1.7 1.8
Eye problems/disorders: Diabetes related eye disease 3.4 3.7 4.4 -2.0 1.9 2.1 -1.7 -2.0 -1.8 -2.1 -1.8 -1.8 -1.7 -2.0 -1.7 -2.0 -2.1 -1.9 2.0
Angina 0.5 0.6 2.0 -0.5 1.2 1.0 -1.1 -0.6 -1.4 -0.5 -0.9 -0.7 -0.4 -0.4 -0.9 -0.5 -0.6 -0.5 0.5
Medication for hormone replacement therapy 2.6 3.0 5.1 1.7 -1.7 -1.8 1.7 1.6 2.2 2.0 2.0 1.1 2.3 1.4 1.5 1.2 1.7 1.8 -1.4
Vitamin and mineral supplements 0.1 0.1 0.4 -0.3 -0.0 0.1 0.2 -0.3 -0.5 0.1 -0.2 0.2 -0.6 -0.4 0.1 -0.3 -0.2 0.3 0.3
Supplements: Zinc 0.1 0.1 0.6 0.2 0.4 0.1 -0.8 0.2 -0.3 0.1 -0.2 0.6 -0.1 0.0 0.3 0.1 0.2 -0.1 0.2
Medication: Co-codamol 1.1 1.3 3.2 1.1 -1.3 -1.0 1.6 1.0 1.8 1.0 1.4 1.0 0.2 0.6 0.9 0.6 1.2 1.3 -0.8
Medication: Metformin 2.1 2.9 3.7 -1.9 1.8 1.7 -1.7 -1.8 -1.7 -1.5 -1.7 -1.3 -1.7 -1.9 -1.5 -1.7 -1.9 -1.6 1.9
Diabetes (father) 0.6 0.7 1.4 1.0 -0.7 -1.0 0.8 0.8 0.6 0.8 0.8 1.1 0.4 0.7 0.9 0.4 1.2 1.0 -0.7
Diabetes (mother) 0.7 0.9 1.5 -0.9 1.2 1.1 -1.0 -1.0 -0.9 -0.8 -0.8 -1.1 -0.5 -1.0 -0.9 -1.1 -1.0 -0.8 1.0
Severe depression (siblings) 0.3 0.3 0.6 -0.5 0.3 0.3 -0.5 -0.4 -0.7 -0.4 -0.6 -0.8 -0.7 -0.5 -0.7 -0.3 -0.6 -0.7 0.4
Pack years adult smoking proportion 2.2 3.4 5.1 -1.8 2.0 2.3 -1.7 -1.9 -1.6 -1.8 -1.6 -1.7 -1.8 -2.0 -1.3 -2.0 -1.8 -1.9 2.0
Impedance of leg (right) 0.7 3.3 4.5 -1.9 2.0 2.1 -1.9 -1.9 -2.1 -2.1 -1.8 -1.8 -0.7 -1.6 -1.7 -1.8 -1.9 -1.8 1.7
Leg fat-free mass (left) 1.4 7.4 11.6 2.8 -3.4 -3.4 3.3 2.8 3.0 3.0 3.0 2.4 -0.3 2.1 2.1 2.5 2.9 2.6 -2.5
Trunk fat percentage 0.3 1.3 9.2 -0.7 0.5 0.2 -0.7 -0.7 -0.6 -0.9 -0.8 -0.9 -3.0 -1.2 -1.4 -0.8 -0.7 -1.0 1.1
Hand grip strength (right) 0.9 2.3 6.0 -1.5 1.2 1.2 -1.2 -1.6 -1.2 -1.5 -1.2 -1.4 -2.5 -1.7 -1.5 -2.0 -1.3 -1.3 1.6
Townsend deprivation index at recruitment 2.6 3.6 4.9 -2.1 1.5 1.9 -1.3 -2.1 -1.4 -1.9 -1.9 -1.9 -1.6 -2.2 -2.2 -2.2 -2.0 -1.9 2.0
Current tobacco smoking 1.2 2.0 3.0 -1.5 1.7 1.7 -1.4 -1.5 -1.7 -1.7 -1.4 -1.6 -1.2 -1.0 -0.9 -1.1 -1.6 -1.0 1.2
Average weekly fortified wine intake 1.4 1.7 3.0 -1.3 1.3 1.7 -0.6 -1.3 -1.6 -1.4 -1.0 -1.5 -0.7 -1.3 -1.5 -1.4 -1.3 -1.0 1.1
Maternal smoking around birth 0.1 0.1 1.2 -0.2 0.0 0.4 0.3 -0.2 0.3 -0.6 0.0 -0.1 1.1 0.0 -0.0 -0.0 -0.2 -0.1 -0.0
Fed-up feelings 0.5 0.9 1.8 -1.2 0.6 0.9 -0.6 -1.2 -0.6 -1.0 -0.7 -0.9 0.3 -1.1 -0.8 -1.4 -1.1 -1.2 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.0 -1.3 0.3 0.5 -0.6 -1.3 -1.0 -0.8 -1.0 -1.4 0.0 -1.2 -1.0 -1.4 -1.1 -1.3 1.2
Relative age voice broke 0.1 0.1 0.5 0.2 -0.3 -0.5 0.3 0.1 0.5 0.6 0.1 -0.1 0.7 -0.0 -0.1 -0.2 0.2 0.3 0.1
Taking other prescription medications 0.4 0.6 1.1 -0.7 1.0 1.0 -0.8 -0.7 -0.8 -0.9 -0.6 -0.5 -0.2 -0.8 0.2 -0.7 -0.8 -0.6 0.9
Age when periods started (menarche) 0.2 0.5 1.0 0.7 -0.4 -0.4 0.6 0.7 0.5 0.7 0.5 0.5 0.9 0.7 1.0 0.9 0.5 0.9 -0.7
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.8 -1.0 1.0 1.2 -0.6 -1.1 -1.2 -1.1 -1.0 -1.0 -1.0 -1.1 -0.8 -1.3 -0.9 -0.6 1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 4.1 -1.5 1.9 1.7 -1.8 -1.5 -1.9 -1.2 -1.7 -2.0 -1.8 -1.5 -1.2 -1.4 -1.5 -1.4 1.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.1 0.8 -1.0 -0.8 0.9 0.9 0.6 0.5 0.8 0.7 0.7 1.0 0.6 1.1 0.8 0.7 -1.0
Qualifications: CSEs or equivalent 1.6 2.1 4.4 -1.4 1.3 1.2 -1.6 -1.3 -1.6 -1.2 -1.9 -1.9 -0.7 -1.0 -2.1 -0.9 -1.4 -1.8 1.2
Serious illness, injury or assault to yourself 0.4 0.5 1.4 0.7 -0.9 -0.5 1.2 0.7 0.9 0.6 0.8 0.2 1.0 0.4 0.3 0.4 0.8 0.9 -0.6
High blood pressure 0.2 0.6 2.8 -0.2 1.0 0.2 -1.4 -0.0 -1.6 -0.5 -0.6 0.0 1.7 -0.2 -0.8 0.0 -0.3 -0.5 0.2
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.0 0.4 -0.7 -0.3 1.0 0.5 0.8 0.4 0.3 -0.0 0.8 0.5 0.6 0.6 0.3 0.6 -0.4
Multivitamins +/- minerals 0.0 0.0 0.1 0.0 -0.0 -0.1 -0.2 0.1 0.3 -0.1 0.2 0.2 0.1 0.2 -0.1 0.1 -0.1 -0.3 -0.1
Stomach or abdominal pain in last month 2.4 3.0 6.1 1.4 -2.3 -1.9 2.5 1.4 2.3 1.7 1.7 0.8 2.2 1.2 1.8 1.4 1.5 1.7 -1.4
Supplements: Glucosamine 1.0 1.3 2.4 1.3 -1.2 -1.1 1.3 1.4 0.5 0.8 0.9 0.1 1.1 1.5 0.9 1.6 1.2 1.1 -1.5
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 4.5 1.6 -2.1 -1.8 2.1 1.6 1.7 1.8 2.0 1.8 0.7 1.1 1.1 1.5 1.7 1.6 -1.5
Medication: Atenolol 0.5 0.6 1.5 -0.6 0.9 0.8 -1.1 -0.6 -1.1 -0.5 -1.0 -0.3 -0.2 -0.6 -1.2 -0.7 -0.6 -0.7 0.6
Medication: Levothyroxine sodium 0.0 0.1 0.3 -0.1 -0.0 0.1 -0.0 -0.1 -0.2 -0.5 -0.1 0.5 -0.2 0.4 -0.2 0.2 -0.1 -0.1 -0.3
Sitting height 3.2 22.9 38.4 4.6 -5.8 -5.2 6.2 4.6 4.9 4.6 5.4 4.7 2.3 3.9 4.6 4.2 4.8 5.1 -4.5
Chronic bronchitis/emphysema (father) 3.7 4.3 6.0 -2.0 2.0 1.7 -2.1 -2.0 -2.4 -2.0 -2.3 -2.0 -2.5 -1.8 -2.3 -2.1 -1.9 -2.0 1.9
High blood pressure (mother) 0.1 0.1 0.6 -0.2 0.4 0.2 -0.7 -0.2 -0.8 -0.1 -0.4 0.3 0.3 -0.2 -0.5 -0.2 -0.3 -0.5 0.2
Body mass index (BMI) 0.1 0.6 1.7 0.9 -1.0 -1.3 0.6 1.0 0.6 0.7 0.5 0.6 -1.1 0.4 -0.0 0.9 1.0 0.5 -0.6
Impedance of leg (left) 0.6 2.7 3.9 -1.6 2.0 1.8 -1.9 -1.7 -1.8 -1.8 -1.7 -1.3 -0.7 -1.5 -1.5 -1.6 -1.7 -1.6 1.7
Leg predicted mass (left) 1.5 7.9 12.1 2.9 -3.5 -3.5 3.4 2.9 3.1 3.0 3.1 2.5 -0.2 2.2 2.2 2.5 3.0 2.8 -2.6
Trunk fat mass 0.2 0.7 6.3 0.5 -0.9 -1.2 0.6 0.6 0.6 0.4 0.5 0.2 -2.5 -0.1 -0.4 0.4 0.6 0.2 -0.1
Waist circumference 0.6 2.0 13.4 -1.1 0.6 0.4 -1.0 -1.0 -0.8 -1.0 -1.2 -1.2 -3.7 -1.5 -1.7 -1.2 -1.0 -1.3 1.2
Number of incorrect matches in round 0.5 0.8 1.7 -0.7 1.2 1.3 -0.7 -0.8 -1.2 -1.1 -0.7 -0.8 -0.1 -0.9 -0.9 -0.7 -0.8 -0.5 0.9
Past tobacco smoking 0.7 1.3 2.9 -1.3 0.9 1.1 -1.0 -1.4 -1.0 -1.1 -1.0 -0.9 -1.7 -1.1 -1.0 -1.4 -1.1 -1.1 1.1
Alcohol usually taken with meals 1.1 1.8 2.4 1.5 -1.4 -1.5 1.5 1.5 1.5 1.6 1.4 0.5 -0.3 1.1 1.0 1.3 1.4 1.5 -1.3
Nervous feelings 0.3 0.6 1.2 -0.9 0.4 0.8 -0.3 -0.9 -0.8 -0.5 -0.6 -0.9 -0.2 -1.0 -1.1 -0.8 -1.0 -0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.7 -1.3 0.2 0.6 -0.4 -1.2 -0.7 -1.0 -0.9 -1.1 0.3 -1.2 -1.3 -1.1 -1.2 -1.3 0.9
Hearing difficulty/problems with background noise 0.1 0.1 0.4 -0.2 0.6 0.7 -0.5 -0.2 -0.6 -0.2 -0.2 0.2 0.5 -0.1 -0.2 -0.1 -0.3 -0.1 0.2
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 0.4 -0.1 -0.1 0.5 0.4 0.4 0.7 0.5 -0.1 0.2 0.0 0.5 0.2 0.3 0.7 -0.0
Had menopause 0.4 0.4 1.2 0.4 -0.7 -0.6 0.7 0.5 0.1 0.3 0.5 1.1 0.8 0.8 0.2 0.7 0.5 0.9 -0.9
Had other major operations 2.1 2.5 4.9 1.6 -1.0 -1.2 1.4 1.7 1.1 1.7 1.7 2.2 0.8 1.6 2.1 1.7 1.5 1.9 -1.6
Forced vital capacity (FVC) 0.3 1.1 7.1 -0.9 0.6 0.5 -0.7 -0.9 -0.7 -0.7 -0.7 -0.4 -2.7 -1.1 -0.9 -1.1 -0.8 -0.7 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.0 -1.1 1.7 1.6 -1.3 -1.2 -1.4 -0.9 -1.0 -1.1 -1.0 -1.2 -0.7 -1.2 -1.2 -0.9 1.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.2 -0.4 0.8 0.6 -0.8 -0.5 -1.1 -0.4 -0.6 -0.6 0.2 -0.6 -0.6 -0.6 -0.5 -0.7 0.7
Qualifications: None of the above 0.2 0.4 4.0 0.2 0.1 0.0 0.2 0.1 0.2 0.2 0.4 0.6 2.0 0.2 0.6 -0.0 0.3 0.8 -0.1
Financial difficulties in last 2 years 7.9 10.6 18.1 -3.4 2.7 3.2 -2.7 -3.3 -3.0 -3.7 -3.1 -4.3 -2.0 -3.1 -3.7 -3.2 -3.4 -3.5 3.1
Mouth/teeth dental problems 0.8 1.2 2.4 -1.1 0.8 0.9 -0.8 -1.2 -1.2 -1.1 -0.8 -0.7 -1.6 -1.2 -1.3 -1.3 -1.0 -1.1 1.1
Heart attack 0.1 0.1 0.3 0.1 0.5 0.4 -0.3 0.0 -0.5 -0.2 -0.1 -0.1 0.4 -0.2 -0.0 -0.1 0.0 -0.0 0.3
Allergy 0.0 0.1 0.7 0.1 0.3 -0.0 -0.5 0.1 -0.5 0.0 0.1 0.6 -0.8 0.0 -0.3 0.0 0.1 -0.0 -0.1
Pain all over the body in last month 0.3 0.3 1.0 -0.5 0.5 0.5 -0.6 -0.5 -0.5 -0.7 -0.6 -1.0 -0.4 -0.2 -0.2 -0.3 -0.6 -0.6 0.4
Diabetes (self-reported) 0.7 1.2 1.8 -1.2 1.3 1.3 -0.9 -1.2 -1.3 -0.8 -0.8 -0.5 -0.6 -1.3 -0.5 -1.2 -1.3 -0.8 1.3
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 0.0 0.3 0.2 -0.1 0.1 0.3 -0.0 0.1 0.2 0.7 -0.4 0.4 0.0 -0.1 0.1 0.4
Medication: Ramipril 0.1 0.1 0.6 -0.2 0.8 0.6 -0.5 -0.3 -0.2 -0.3 0.1 0.1 0.1 -0.4 -0.3 -0.5 -0.2 -0.2 0.4
Medication: Simvastatin 0.4 0.5 0.9 -0.7 0.8 0.6 -0.9 -0.6 -0.9 -0.8 -0.9 0.0 -0.4 -0.8 -0.9 -0.6 -0.7 -0.7 0.7
Fluid intelligence score 3.0 6.2 7.7 2.6 -2.7 -2.6 2.8 2.6 2.4 2.8 2.6 2.5 1.2 2.2 2.7 2.2 2.6 2.7 -2.3
Illnesses of siblings 0.1 0.1 0.6 -0.1 0.1 -0.2 -0.6 -0.1 0.3 -0.1 -0.2 -0.5 -0.8 0.1 -0.4 0.0 -0.1 -0.8 0.1
Neuroticism score 0.8 1.6 2.6 -1.6 0.4 0.9 -0.7 -1.5 -0.9 -1.2 -1.1 -1.4 0.0 -1.5 -1.3 -1.5 -1.5 -1.6 1.5
Weight 1.0 4.8 8.4 2.3 -2.7 -2.9 2.5 2.3 2.3 2.2 2.4 2.1 -1.1 1.5 1.5 1.9 2.4 2.2 -1.9
Impedance of arm (right) 1.6 7.3 9.7 -3.0 2.8 3.1 -2.3 -3.1 -2.4 -3.0 -2.4 -2.5 -2.1 -2.6 -2.2 -3.0 -2.9 -2.7 2.8
Arm fat percentage (right) 0.2 0.9 6.4 -0.6 0.4 0.1 -0.8 -0.6 -0.7 -0.8 -0.8 -0.7 -2.5 -0.9 -1.2 -0.6 -0.6 -1.0 0.8
Trunk fat-free mass 2.9 16.6 22.3 4.2 -4.7 -4.7 4.7 4.2 4.3 4.4 4.4 3.9 1.0 3.4 3.6 3.8 4.3 4.3 -3.9
Hip circumference 1.5 6.4 9.8 2.7 -3.0 -3.1 3.0 2.7 2.6 2.6 2.8 2.6 -0.4 1.7 1.8 2.2 2.9 2.7 -2.1
Time employed in main current job 0.5 0.6 2.4 -0.8 0.8 0.7 -0.7 -0.7 -0.8 -0.5 -0.9 -0.8 -1.5 -0.6 -0.4 -0.6 -0.9 -0.5 0.7
Alcohol intake versus 10 years previously 0.5 0.8 1.7 0.8 -1.3 -1.1 1.2 0.8 1.3 0.8 0.9 0.5 1.1 0.6 0.2 0.7 0.9 0.8 -0.8
Father’s age at death 0.1 0.1 0.4 0.1 -0.6 -0.4 0.0 0.2 -0.2 0.1 -0.2 -0.4 0.1 0.1 -0.5 0.3 0.1 -0.4 -0.3
Worrier / anxious feelings 0.0 0.0 0.2 -0.2 -0.4 -0.5 0.0 -0.1 -0.2 0.1 0.1 -0.0 0.2 -0.0 -0.3 0.0 -0.2 -0.2 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.2 -0.2 -0.4 -0.1 0.4 -0.2 0.2 -0.2 -0.1 -0.2 0.2 -0.3 -0.3 -0.3 -0.2 -0.1 0.2
Falls in the last year 0.9 1.2 2.3 -1.4 0.6 1.0 -0.5 -1.3 -0.9 -1.0 -1.1 -1.5 -0.1 -1.2 -1.1 -1.1 -1.3 -1.1 1.1
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 -0.5 -0.4 -0.2 -0.1 -0.4 -0.0 -0.2 -0.5 0.1 -0.7 -0.0 -0.1 -0.1 -0.4 -0.6 0.0
Number of live births 8.2 11.5 15.1 -3.3 3.7 3.7 -3.3 -3.5 -3.1 -3.6 -3.0 -2.7 -3.1 -3.8 -3.0 -3.9 -3.3 -3.3 3.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 3.7 -0.2 -0.1 -0.4 -0.2 -0.2 0.2 0.1 -0.1 0.3 -1.9 -0.6 -0.2 -0.5 -0.1 -0.1 0.5
Pulse rate 0.1 0.2 1.3 0.2 0.4 0.4 -0.3 0.2 0.4 0.1 0.4 -0.3 1.2 0.2 0.5 0.2 0.2 -0.1 -0.2
Happiness 0.1 0.1 0.4 -0.4 -0.3 0.1 0.2 -0.3 0.0 -0.1 -0.1 -0.5 0.6 -0.1 -0.3 -0.1 -0.4 -0.4 0.1
Noisy workplace 0.2 0.2 0.8 0.4 -0.2 -0.5 0.1 0.5 0.1 0.5 0.2 0.5 0.6 0.6 0.9 0.6 0.4 0.4 -0.3
Qualifications: A levels/AS levels or equivalent 0.6 1.2 2.0 1.1 -1.4 -1.2 1.2 1.2 1.2 1.4 1.2 0.7 -0.7 0.9 0.9 1.1 1.0 1.0 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 0.9 0.8 -0.8 -0.7 0.8 0.8 0.1 0.8 0.7 0.7 0.3 0.8 0.8 0.9 0.8 0.8 -0.9
Mouth/teeth dental problems: Dentures 0.4 0.6 1.8 0.7 -0.7 -0.8 0.5 0.8 0.4 0.6 0.4 0.6 0.3 1.4 0.5 1.2 0.7 0.6 -1.3
Asthma 0.9 1.7 2.6 -1.4 1.4 1.4 -1.2 -1.4 -1.0 -1.3 -1.3 -1.6 -0.4 -1.4 -1.1 -1.4 -1.4 -1.4 1.4
Medication: Ibuprofen (e.g. Nurofen) 2.8 3.6 6.3 1.6 -1.8 -1.6 2.2 1.6 2.5 1.6 2.2 1.7 2.3 1.5 2.2 1.6 1.7 2.1 -1.7
Medication: Cholesterol lowering 0.7 1.0 2.6 -1.0 1.0 1.2 -1.0 -0.9 -1.6 -1.3 -1.1 -0.7 -0.7 -0.6 -1.3 -0.7 -1.0 -1.0 0.5
Depression (self-reported) 0.1 0.2 1.1 -0.1 -1.1 -0.7 0.5 -0.1 -0.1 -0.0 0.3 -0.1 -0.0 0.4 0.3 0.1 0.2 -0.2 -0.4
Medication: Lansoprazole 0.3 0.3 1.6 -0.0 0.7 0.2 -1.0 -0.0 -0.8 -0.4 -0.7 0.1 -1.3 -0.0 -0.3 0.1 -0.1 -0.4 0.2
Prospective memory result 1.1 1.4 2.2 -1.1 1.5 1.4 -1.1 -1.2 -1.4 -1.1 -1.2 -1.3 -0.8 -1.2 -1.0 -1.1 -1.2 -0.7 1.3
Lung cancer (father) 0.8 0.9 1.8 0.8 -1.1 -0.9 1.2 0.8 0.5 0.9 0.6 0.3 1.3 1.3 0.5 1.1 0.9 0.9 -1.4
Illnesses of mother 0.2 0.2 0.8 0.4 -0.3 -0.4 0.4 0.4 0.9 0.3 0.2 0.2 -0.4 0.3 0.7 0.5 0.4 0.8 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 6.4 -0.8 0.5 0.3 -0.7 -0.9 -0.5 -0.5 -0.6 -0.3 -2.5 -1.5 -0.8 -1.2 -0.7 -0.6 1.3
Pulse wave Arterial Stiffness index 0.2 0.2 1.2 0.5 -0.0 -0.3 -0.2 0.5 0.1 0.1 0.0 0.4 1.1 0.6 -0.1 0.6 0.5 0.3 -0.5
Impedance of arm (left) 1.9 8.9 11.8 -3.2 3.1 3.4 -2.5 -3.4 -2.6 -3.4 -2.6 -2.8 -2.5 -2.9 -2.5 -3.3 -3.2 -2.9 3.1
Arm fat mass (right) 0.2 0.9 3.0 0.9 -1.2 -1.4 0.8 1.0 0.8 0.8 0.8 0.7 -1.7 0.5 0.1 0.9 1.0 0.6 -0.7
Trunk predicted mass 3.0 17.2 23.1 4.2 -4.8 -4.8 4.7 4.3 4.3 4.5 4.5 4.0 1.1 3.5 3.6 3.8 4.4 4.3 -3.9
Standing height 1.1 10.7 19.1 3.1 -3.9 -3.6 4.4 3.0 3.8 3.3 4.0 3.3 -0.4 2.4 3.2 2.4 3.3 3.6 -2.9
Length of working week for main job 2.0 2.2 5.2 1.5 -1.2 -1.1 1.6 1.5 1.2 1.4 1.7 1.4 2.3 1.3 1.4 1.3 1.5 1.7 -1.4
Exposure to tobacco smoke at home 1.9 2.1 2.8 -1.5 1.5 1.3 -1.7 -1.4 -1.4 -1.6 -1.5 -1.1 -1.2 -1.6 -1.1 -1.5 -1.6 -1.6 1.7
Breastfed as a baby 0.5 0.6 1.0 1.0 -0.6 -0.6 0.6 1.0 1.0 0.7 0.9 0.6 -0.2 0.7 0.9 0.9 0.9 0.5 -0.8
Tense / ‘highly strung’ 0.9 1.5 2.8 -1.4 1.2 1.0 -1.2 -1.4 -1.1 -0.9 -1.2 -1.0 -0.2 -1.7 -1.2 -1.6 -1.3 -1.1 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 3.7 1.6 -1.9 -1.9 1.7 1.6 1.2 1.6 1.5 1.2 1.9 1.9 1.7 1.7 1.6 1.4 -1.8
Hair/balding pattern: Pattern 4 0.1 0.3 3.6 -0.3 0.3 0.2 -0.2 -0.3 -0.4 -0.3 -0.2 -0.2 -1.9 -0.5 -0.6 -0.4 -0.2 -0.1 0.4
Birth weight of first child 0.8 1.5 2.5 1.1 -1.3 -1.2 1.1 1.2 1.4 1.6 1.0 1.4 0.3 1.2 1.5 1.3 1.3 1.2 -1.2
Peak expiratory flow (PEF) 0.4 0.9 2.4 0.6 -1.2 -1.4 0.8 0.6 1.3 1.2 1.0 1.5 0.1 0.6 0.8 0.7 0.7 0.7 -0.6
Pulse wave reflection index 0.7 0.9 2.2 1.1 -1.0 -1.5 0.6 1.1 0.2 0.9 0.6 0.9 1.0 1.0 0.2 1.1 1.1 0.8 -1.0
Ever highly irritable/argumentative for 2 days 1.8 2.2 4.0 -1.6 1.0 1.4 -0.8 -1.7 -0.9 -1.6 -1.6 -2.0 -0.7 -1.7 -1.4 -1.8 -1.6 -1.6 1.7
Loud music exposure frequency 3.8 4.1 8.0 1.9 -1.8 -1.8 1.9 2.0 2.1 2.0 2.2 2.0 2.8 2.0 1.7 2.1 1.9 2.0 -2.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 4.8 -0.7 0.3 0.6 -0.4 -0.6 -0.6 -0.9 -0.4 -1.1 -2.2 -0.5 -0.8 -0.3 -0.7 -1.0 0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 -0.5 1.0 0.7 -1.0 -0.4 -0.6 -0.4 -0.6 -0.5 -0.2 -0.9 -0.2 -0.5 -0.6 -0.7 0.9
Blood clot in the leg (DVT) 0.1 0.1 0.5 0.1 -0.4 -0.2 0.7 -0.1 0.5 0.0 0.4 -0.1 0.6 -0.2 0.2 -0.5 0.3 0.3 0.1
Medication: Paracetamol 0.0 0.0 0.2 0.0 -0.4 -0.3 -0.0 0.1 -0.1 0.2 -0.2 -0.0 0.5 0.1 0.0 0.2 0.0 0.1 -0.2
Headache pain in last month 0.1 0.2 0.8 0.3 -0.6 -0.2 0.9 0.3 0.5 -0.0 0.6 0.9 -0.6 0.2 0.5 0.3 0.3 0.3 -0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.5 0.1 -0.1 -0.3 0.1 -0.0 0.7 0.3 0.1 -0.0 -0.6 -0.3 0.6 -0.2 0.1 0.2 0.4
Glaucoma (self-reported) 0.1 0.1 0.5 -0.2 0.2 0.6 0.1 -0.2 -0.7 -0.5 -0.5 -0.4 0.5 -0.2 -0.2 -0.3 -0.3 0.0 0.1
Gout (self-reported) 0.4 0.6 1.5 -0.5 1.2 0.6 -1.0 -0.6 -0.2 -0.5 -0.5 -0.6 -1.2 -1.0 -0.4 -0.9 -0.6 -0.6 1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 -0.6 0.6 0.7 -0.5 -0.7 -0.5 -1.0 -0.3 0.3 -0.3 -0.5 -0.6 -0.6 -0.6 -0.7 0.4
Medication: Amlodipine 1.3 1.8 3.6 -1.2 1.8 1.3 -1.9 -1.1 -1.9 -1.1 -1.6 -1.5 0.3 -1.1 -1.1 -0.8 -1.4 -1.1 1.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.5 -1.2 1.4 1.6 -0.9 -1.2 -0.9 -1.3 -0.8 -1.1 -0.8 -1.2 -0.6 -1.1 -1.3 -0.8 1.3
Birth weight 4.3 9.3 12.2 3.3 -2.9 -3.1 2.9 3.2 3.5 3.4 3.1 3.0 2.0 2.7 2.9 2.8 3.4 3.4 -2.8
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.8 0.4 -0.6 -0.2 1.2 0.1 1.1 0.4 0.9 0.1 1.3 0.0 0.8 -0.4 0.6 0.5 -0.2
High blood pressure (siblings) 0.1 0.2 1.0 -0.2 0.5 0.4 -0.4 -0.2 -1.0 -0.3 -0.5 0.1 0.6 -0.3 -0.2 -0.2 -0.3 -0.0 0.3
Forced vital capacity (FVC), Best measure 0.7 2.5 9.7 -1.5 1.3 1.2 -1.2 -1.5 -1.3 -1.3 -1.1 -1.0 -3.1 -1.9 -1.2 -1.9 -1.4 -1.1 1.8
Body fat percentage 0.2 0.9 7.1 -0.5 0.4 0.0 -0.7 -0.4 -0.6 -0.7 -0.7 -0.7 -2.7 -1.0 -1.3 -0.5 -0.4 -0.9 0.9
Leg fat percentage (right) 0.1 0.3 2.6 0.1 -0.2 -0.5 -0.3 0.2 -0.5 -0.1 -0.3 -0.2 -1.6 -0.4 -1.0 0.0 0.1 -0.3 0.2
Arm fat-free mass (right) 2.1 10.6 16.2 3.4 -3.9 -4.0 3.6 3.5 3.4 3.6 3.5 3.1 0.4 2.6 2.5 3.1 3.5 3.3 -3.1
Exposure to tobacco smoke outside home 1.5 1.9 2.9 -1.3 1.6 1.5 -1.7 -1.3 -1.2 -1.6 -1.3 -1.3 -0.9 -1.3 -1.2 -1.2 -1.5 -1.7 1.4
Comparative body size at age 10 0.1 0.3 1.3 0.1 -0.6 -0.7 -0.1 0.3 0.3 0.4 -0.3 -0.9 -1.1 0.4 -0.9 0.6 0.1 -0.2 -0.4
Number of full brothers 0.8 1.1 2.6 -0.9 1.4 1.6 -0.9 -1.0 -1.4 -1.1 -0.9 -0.2 -0.7 -1.1 -0.7 -1.1 -1.0 -0.6 1.1
Worry too long after embarrassment 2.0 3.4 6.3 1.6 -2.5 -2.0 2.1 1.7 1.6 1.7 1.8 1.4 2.5 1.8 1.3 1.9 1.6 1.4 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.7 1.0 -1.6 -1.6 1.3 1.1 0.9 1.1 0.9 0.4 1.4 1.2 0.8 1.3 1.0 1.0 -1.2
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 0.3 -0.3 -0.0 0.7 0.4 0.5 0.1 0.3 -0.1 0.8 0.4 0.5 0.6 0.2 0.4 -0.5
Number of children fathered 0.9 1.1 1.9 1.2 -0.4 -1.0 0.4 1.1 0.9 1.3 1.0 1.4 0.8 0.8 1.3 0.9 1.3 1.2 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 3.0 3.5 7.7 1.8 -1.5 -1.3 1.9 1.6 2.3 1.6 2.0 2.0 2.8 1.5 1.9 1.4 1.9 2.1 -1.5
Age at first live birth 0.6 1.1 1.8 1.2 -1.3 -1.2 1.0 1.2 0.9 1.3 1.1 0.9 0.3 1.1 0.9 1.1 1.2 1.0 -1.2
Pulse wave peak to peak time 0.1 0.2 0.8 0.1 -0.5 -0.2 0.7 0.0 0.5 0.4 0.6 0.2 -0.9 -0.1 0.7 -0.1 0.1 0.3 0.0
Health satisfaction 0.5 0.7 1.0 -0.8 0.8 0.6 -1.0 -0.8 -0.6 -0.8 -0.9 -1.0 -0.1 -0.9 -1.0 -0.8 -0.9 -0.9 0.9
Shortness of breath walking on level ground 1.6 1.9 3.5 -1.3 1.4 1.1 -1.4 -1.4 -1.3 -1.4 -1.6 -1.3 -0.4 -1.9 -1.2 -1.6 -1.3 -1.1 1.9
Qualifications: College or University degree 0.1 0.4 1.4 0.4 -1.1 -0.5 1.2 0.3 0.8 0.6 0.7 0.3 -1.1 -0.1 0.3 -0.2 0.5 0.6 -0.3
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.3 -0.3 -0.6 0.2 0.4 0.7 0.7 0.4 0.5 -0.0 0.5 0.2 0.7 0.4 0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.7 0.7 -0.8 -0.8 0.7 0.7 0.8 0.6 0.5 0.4 0.1 0.3 0.6 0.4 0.8 0.6 -0.3
Emphysema/chronic bronchitis 1.1 1.2 1.9 -1.1 1.2 1.3 -1.3 -1.0 -1.2 -1.4 -1.3 -1.3 -0.5 -0.7 -0.8 -0.7 -1.1 -1.3 1.0
Medication for pain relief, constipation, heartburn 0.1 0.1 1.2 -0.2 0.1 0.1 -0.2 -0.2 -0.0 -0.3 0.1 -0.4 -1.1 -0.2 -0.2 -0.2 -0.2 -0.6 0.3
Neck or shoulder pain in last month 1.4 1.9 2.9 1.3 -1.4 -1.4 1.3 1.4 0.8 1.7 1.1 1.2 1.4 1.7 1.7 1.7 1.2 1.4 -1.4
Medication: Blood pressure 0.2 0.4 1.8 -0.4 0.8 0.6 -0.9 -0.3 -1.3 -0.5 -0.7 -0.2 0.3 -0.0 -0.9 -0.2 -0.4 -0.5 0.0
Angina (self-reported) 0.9 1.2 2.8 -0.8 1.5 1.2 -1.5 -0.9 -1.7 -0.8 -1.2 -1.1 -0.7 -0.7 -1.3 -0.8 -0.9 -0.9 0.7
Migraine (self-reported) 7.0 8.7 11.4 -3.2 2.1 2.7 -2.2 -3.2 -2.9 -3.3 -3.0 -3.3 -2.7 -2.8 -3.4 -3.1 -3.1 -3.2 2.7
Medication: Ibuprofen 0.2 0.3 1.0 0.2 -0.2 -0.1 0.6 0.3 1.0 0.2 0.7 0.4 1.0 0.3 0.8 0.5 0.2 0.6 -0.3
Medication: Allopurinol 0.0 0.0 0.1 0.1 0.3 -0.1 -0.1 0.0 0.4 0.2 0.3 0.1 -0.2 -0.2 0.3 -0.2 0.0 0.1 0.3
Medication: Omeprazole 0.1 0.1 0.3 0.4 -0.4 -0.4 0.5 0.4 0.6 0.5 0.3 0.2 0.3 0.1 0.3 0.2 0.3 0.3 -0.2
Medication: Seretide 50 evohaler 0.1 0.1 0.4 0.2 -0.2 -0.2 0.0 0.2 0.1 0.5 -0.0 0.1 0.6 0.5 0.5 0.4 0.2 0.3 -0.3
Mean time to correctly identify matches 1.6 3.0 6.2 -1.6 2.5 2.3 -1.8 -1.7 -1.2 -1.9 -1.4 -0.8 -1.2 -2.1 -1.2 -2.1 -1.6 -1.3 2.1
Heart disease (mother) 0.2 0.2 0.8 -0.5 0.4 0.6 -0.4 -0.5 -0.9 -0.4 -0.4 -0.3 -0.0 -0.2 -0.6 -0.5 -0.4 -0.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.9 -0.1 0.2 0.0 -0.4 -0.2 -0.3 -0.1 -0.3 1.0 0.5 0.1 0.3 -0.2 0.1 0.0 0.0
Whole body fat mass 0.2 0.8 4.5 0.8 -1.0 -1.3 0.7 0.8 0.7 0.6 0.7 0.4 -2.1 0.1 -0.2 0.6 0.8 0.4 -0.4
Leg fat mass (right) 0.3 1.2 3.2 1.2 -1.5 -1.8 1.0 1.3 0.8 1.1 1.0 0.8 -1.4 0.6 0.0 1.1 1.3 0.8 -0.9
Arm predicted mass (right) 2.2 11.3 16.8 3.5 -4.0 -4.1 3.7 3.6 3.5 3.7 3.5 3.2 0.5 2.7 2.7 3.2 3.6 3.4 -3.2
Pulse rate, automated reading 0.1 0.3 2.0 -0.3 0.9 0.4 -1.4 -0.1 -0.5 -0.1 -0.6 -0.1 0.6 0.3 0.2 0.3 -0.4 -0.7 0.0
Alcohol intake frequency. 0.8 1.8 3.4 -1.4 0.8 1.1 -0.7 -1.4 -1.4 -1.5 -1.1 -1.1 -1.9 -1.6 -1.5 -1.4 -1.4 -1.2 1.4
Comparative height size at age 10 1.1 6.1 8.6 2.4 -2.9 -2.8 2.9 2.4 2.6 2.4 2.6 2.6 -0.7 2.3 2.3 2.2 2.5 2.7 -2.5
Number of full sisters 0.6 0.7 1.0 1.0 -0.6 -0.7 0.6 0.9 0.7 0.7 0.9 1.0 0.6 0.9 1.0 0.8 1.0 0.8 -0.7
Suffer from ‘nerves’ 0.7 1.1 1.9 -1.4 0.3 0.8 -0.3 -1.3 -0.8 -0.8 -0.9 -1.2 -0.8 -1.1 -1.4 -1.3 -1.3 -1.0 1.0
Overall health rating 0.9 2.0 3.3 -1.7 1.2 1.2 -1.4 -1.5 -1.8 -1.5 -1.7 -1.1 -0.4 -1.3 -1.6 -1.3 -1.6 -1.5 1.3
Chest pain or discomfort 0.1 0.1 0.4 -0.2 0.0 0.3 0.1 -0.1 -0.4 -0.2 -0.4 -0.5 0.7 -0.1 -0.3 0.1 -0.3 -0.2 -0.1
Had major operations 0.1 0.1 0.9 -0.3 -0.3 0.2 0.6 -0.2 -0.2 -0.4 -0.1 -1.0 -0.2 -0.4 -0.5 0.0 -0.4 -0.1 0.1
Age at last live birth 0.8 1.1 1.8 1.0 -0.9 -0.9 0.7 1.0 0.9 1.4 1.2 1.2 1.3 1.1 1.1 1.0 1.0 1.0 -1.1
Family relationship satisfaction 0.6 0.7 1.3 -1.1 0.3 0.9 -0.2 -1.1 -0.8 -0.9 -0.9 -1.0 0.0 -0.9 -0.7 -1.0 -1.1 -0.9 0.8
Leg pain on walking 2.9 3.6 5.5 1.9 -2.1 -1.9 2.0 2.0 1.5 1.8 1.7 1.5 2.3 2.1 1.4 2.2 1.8 1.9 -2.2
Qualifications: NVQ or HND or HNC or equivalent 5.7 6.8 9.9 -2.5 2.5 2.6 -2.9 -2.4 -3.1 -3.1 -2.9 -2.2 -2.5 -1.9 -2.9 -2.1 -2.5 -3.1 2.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.5 0.0 0.6 0.1 -0.7 -0.0 -0.1 0.1 -0.3 -0.2 -0.5 0.1 -0.0 0.0 -0.1 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.4 0.6 -0.7 -0.8 0.8 0.6 1.2 0.7 1.0 1.2 0.3 0.5 0.9 0.5 0.6 0.8 -0.5
Medication: Aspirin 1.6 2.1 3.9 -1.4 1.9 1.7 -1.7 -1.4 -2.0 -1.3 -1.7 -0.7 -0.4 -1.3 -1.5 -1.6 -1.4 -1.2 1.4
Supplements: Vitamin C 1.6 1.9 4.1 1.5 -1.0 -1.2 1.2 1.5 2.0 1.1 1.6 0.8 1.9 1.1 1.4 1.5 1.3 1.2 -1.2
Knee pain experienced in last month 2.5 3.8 5.4 1.9 -2.3 -2.1 2.3 1.9 1.8 2.1 2.1 1.5 1.9 1.9 1.8 1.8 2.0 2.0 -2.0
Hypertension (Self-reported) 0.3 1.0 3.2 -0.5 1.3 0.6 -1.7 -0.4 -1.8 -0.8 -0.9 -0.3 1.5 -0.6 -1.0 -0.3 -0.6 -0.8 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.0 0.9 -0.2 -0.5 0.1 1.0 0.6 0.8 0.6 0.5 0.3 0.7 0.4 1.0 0.8 0.7 -0.7
Illnesses of father: Heart disease 0.1 0.2 0.9 -0.1 0.4 0.3 -0.2 -0.2 -1.0 -0.5 -0.4 0.2 -0.0 -0.6 0.1 -0.6 -0.2 0.0 0.6
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.2 0.0 0.4 0.4 -0.3 -0.6 -0.5 -0.3 -0.4 0.0 -0.6 -0.4 -0.5 -0.2 0.2 0.4
Smoking status: Previous 3.1 4.6 5.8 2.3 -2.2 -2.4 2.1 2.4 2.1 2.3 2.0 1.8 2.3 2.0 1.7 2.3 2.2 2.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.7 0.7 -0.9 -1.0 1.0 0.6 1.3 0.7 0.9 0.9 -1.0 0.2 0.7 0.4 0.8 0.7 -0.4
Whole body fat-free mass 2.3 13.0 18.3 3.7 -4.2 -4.3 4.2 3.7 3.9 4.0 3.9 3.5 0.5 2.9 3.1 3.3 3.8 3.7 -3.4
Leg fat-free mass (right) 1.5 7.9 12.1 2.8 -3.4 -3.5 3.3 2.9 3.2 3.1 3.1 2.6 -0.2 2.1 2.3 2.5 3.0 2.8 -2.5
Arm fat percentage (left) 0.3 1.3 7.5 -0.8 0.7 0.4 -1.0 -0.7 -0.8 -1.0 -1.0 -0.9 -2.7 -1.1 -1.5 -0.8 -0.7 -1.2 1.0
Average weekly red wine intake 0.7 1.0 1.9 1.1 -0.7 -1.1 0.8 1.1 1.1 1.4 1.0 0.8 0.3 1.0 0.9 0.9 1.2 1.4 -1.0
Handedness (chirality/laterality): Left-handed 3.6 4.3 5.8 2.0 -1.9 -2.0 2.1 1.9 2.1 2.2 2.3 2.4 2.0 1.8 2.2 1.8 2.1 2.4 -1.9
Mood swings 0.1 0.1 0.5 -0.5 -0.4 -0.2 0.1 -0.4 -0.1 -0.2 -0.1 -0.1 0.7 -0.3 -0.0 -0.2 -0.5 -0.5 0.2
Loneliness, isolation 0.1 0.1 0.5 -0.1 -0.5 -0.2 0.4 -0.1 0.3 -0.1 0.1 -0.7 0.6 -0.1 -0.3 -0.0 -0.1 -0.2 0.0
Long-standing illness, disability or infirmity 0.3 0.5 0.8 -0.8 0.6 0.7 -0.6 -0.9 -0.6 -0.9 -0.6 -0.6 -0.2 -0.7 -0.7 -0.9 -0.8 -0.6 0.7
Ever had bowel cancer screening 0.7 0.8 1.5 0.6 -1.1 -0.8 1.2 0.7 0.8 0.8 1.1 0.6 0.4 1.0 0.8 1.0 0.6 1.0 -1.0
Diabetes diagnosed by doctor 1.2 2.0 3.5 -1.5 1.9 1.7 -1.3 -1.5 -1.6 -1.2 -1.1 -0.8 -0.9 -1.6 -0.6 -1.5 -1.7 -1.0 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.8 1.0 -1.3 -1.2 0.8 0.9 1.4 1.0 0.9 0.6 0.8 0.9 1.0 0.8 1.1 0.4 -0.8
Friendships satisfaction 0.6 0.7 1.5 -1.0 0.3 0.8 -0.4 -0.9 -0.6 -0.7 -0.8 -1.2 -0.6 -0.8 -1.1 -0.7 -1.0 -1.1 0.6
Qualifications: nursing, teaching 0.1 0.1 1.1 0.2 -0.6 -0.3 0.3 0.3 0.3 0.2 0.3 0.1 -1.1 0.1 0.1 0.3 0.2 -0.1 -0.4
Commuting to job workplace: Walk 2.5 2.7 5.3 1.8 -2.1 -1.8 2.3 1.7 1.7 1.8 1.8 1.2 0.8 1.0 1.7 1.2 1.8 1.9 -1.2
Eye problems/disorders: Cataract 0.4 0.4 1.1 0.6 -0.7 -0.4 0.9 0.5 0.6 0.4 0.7 0.2 1.0 0.5 0.8 0.4 0.6 0.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.3 0.9 -1.0 -1.0 1.0 1.0 1.0 1.0 0.6 0.7 1.3 1.0 1.5 1.1 0.9 1.3 -0.9
Medication for cholesterol 0.4 0.6 4.7 -0.7 -0.1 0.8 0.2 -0.6 -0.7 -1.0 -0.7 -0.7 -2.2 -0.1 -0.5 -0.2 -0.7 -0.7 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.1 -1.2 1.3 1.1 -1.8 -1.1 -0.8 -1.1 -1.4 -1.6 -0.9 -0.7 -1.1 -0.9 -1.3 -1.6 0.9
Back pain experienced in last month 1.2 1.7 2.5 1.5 -1.0 -1.3 0.9 1.5 1.4 1.3 1.1 1.0 1.6 1.2 1.4 1.5 1.5 1.5 -1.2
Mineral and other dietary supplements 0.8 1.1 3.5 -1.1 0.4 0.6 -0.3 -1.2 -0.5 -0.7 -0.5 -0.5 -1.9 -1.5 -1.0 -1.6 -0.9 -0.7 1.3
Breast cancer (self-reported) 0.1 0.1 0.8 0.1 -0.4 -0.2 0.4 0.1 -0.0 0.2 -0.0 0.1 0.9 0.2 -0.2 0.3 0.1 0.0 -0.3
Asthma (self-reported) 1.1 2.1 2.9 -1.6 1.5 1.5 -1.5 -1.6 -1.2 -1.5 -1.5 -1.7 -0.6 -1.4 -1.3 -1.5 -1.6 -1.6 1.5
Osteoporosis (self-reported) 1.4 1.8 3.5 1.4 -0.9 -1.2 0.8 1.5 0.9 1.5 0.9 1.2 0.8 1.8 1.6 1.9 1.3 1.4 -1.6
Osteoarthritis (self-reported) 0.9 1.2 1.9 1.1 -1.0 -0.9 1.0 1.1 0.8 1.0 0.8 0.9 1.4 1.3 1.1 1.2 1.1 1.3 -1.2
Medication: Aspirin 1.1 1.4 3.1 -1.1 1.4 1.3 -1.4 -1.2 -1.8 -1.1 -1.4 -0.6 -0.3 -1.0 -1.3 -1.4 -1.1 -0.9 1.1
Medication: Gliclazide 0.1 0.1 0.4 -0.1 0.4 0.3 -0.1 -0.2 -0.4 0.0 -0.2 0.7 -0.3 -0.4 0.4 -0.3 -0.2 0.2 0.5
Illnesses of father: None of the above (group 1) 0.1 0.2 0.4 0.1 -0.5 -0.3 0.5 0.2 0.5 0.6 0.3 0.1 0.0 0.5 0.0 0.7 -0.0 0.2 -0.5
Smoking status: Current 1.6 2.6 4.2 -1.7 2.0 2.0 -1.7 -1.6 -1.8 -1.9 -1.6 -1.7 -1.2 -1.2 -1.1 -1.3 -1.8 -1.2 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.1 6.1 -2.1 1.8 1.7 -1.8 -2.1 -2.5 -1.7 -2.1 -1.7 -2.4 -2.2 -2.0 -2.3 -2.0 -1.5 2.2
Whole body water mass 2.5 14.0 19.7 3.9 -4.4 -4.4 4.2 3.9 4.0 4.1 4.0 3.6 0.6 3.1 3.2 3.5 4.0 3.9 -3.5
Leg predicted mass (right) 1.5 8.1 12.4 2.9 -3.4 -3.5 3.3 2.9 3.3 3.1 3.1 2.7 -0.2 2.1 2.3 2.5 3.0 2.8 -2.5
Arm fat mass (left) 0.3 1.1 3.1 1.0 -1.4 -1.6 1.0 1.1 0.9 0.9 0.9 0.8 -1.8 0.5 0.1 0.9 1.1 0.7 -0.8
Number of self-reported non-cancer illnesses 0.0 0.1 0.5 -0.1 0.3 -0.0 -0.4 -0.1 -0.4 -0.2 -0.3 -0.0 0.7 -0.1 0.2 -0.1 -0.1 -0.2 0.2
Average weekly champagne plus white wine intake 0.0 0.0 0.1 0.2 0.3 -0.1 -0.3 0.2 0.3 0.2 -0.0 -0.1 0.2 0.1 -0.0 0.1 0.2 0.1 0.1
Miserableness 0.9 1.5 3.4 -1.4 0.4 0.7 -0.9 -1.4 -1.2 -1.4 -1.2 -1.5 -0.0 -1.2 -1.2 -1.3 -1.3 -1.8 1.2
Guilty feelings 2.5 3.7 8.9 1.6 -2.7 -1.8 3.0 1.6 2.3 1.6 2.2 1.3 2.4 1.3 1.7 1.3 1.8 1.7 -1.6
Wears glasses or contact lenses 0.3 0.3 0.9 -0.5 0.5 0.2 -0.6 -0.5 -0.1 -0.4 -0.5 -0.9 -0.6 -0.6 -0.7 -0.5 -0.6 -0.5 0.6
Ever taken oral contraceptive pill 0.7 0.7 1.8 0.8 -0.7 -0.4 1.0 0.8 1.1 0.8 0.9 0.7 1.4 0.8 1.1 0.8 0.7 0.7 -0.8
Hearing aid user 0.3 0.4 0.7 0.6 -0.5 -0.4 0.6 0.5 0.7 0.5 0.6 0.8 0.5 0.5 0.7 0.4 0.6 0.7 -0.6
Mother’s age at death 0.7 0.9 2.0 -0.8 0.7 0.8 -1.1 -0.8 -1.2 -0.7 -1.2 -1.4 -1.2 -0.5 -1.3 -0.5 -0.8 -1.0 0.6
Financial situation satisfaction 6.2 7.7 9.9 -3.0 2.5 2.5 -2.9 -2.8 -2.9 -2.9 -3.1 -3.1 -1.7 -2.4 -3.1 -2.4 -3.0 -3.1 2.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 0.5 -0.3 -0.5 0.4 0.5 1.0 0.8 0.7 0.8 1.1 0.5 0.9 0.5 0.6 0.7 -0.4
Commuting to job workplace: Public transport 0.0 0.0 0.3 0.0 -0.5 -0.3 0.4 0.1 0.1 0.1 -0.0 -0.0 -0.0 -0.1 -0.4 0.0 0.1 0.1 0.1
Eye problems/disorders: Glaucoma 0.3 0.4 1.4 -0.6 0.4 0.7 -0.4 -0.6 -1.2 -0.7 -0.8 -0.6 -0.2 -0.5 -0.6 -0.6 -0.6 -0.5 0.4
Medication: Blood pressure 0.9 1.6 3.6 -1.1 1.8 1.0 -1.9 -1.2 -1.2 -1.0 -1.1 -0.9 0.6 -1.5 -1.4 -1.4 -1.1 -1.1 1.5
Pain type(s) experienced in last month: Hip pain 1.3 1.6 4.5 1.1 -0.8 -0.8 1.2 1.0 1.4 1.4 1.2 1.4 1.4 1.0 2.1 1.1 1.0 1.8 -0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.7 0.8 -0.1 -0.2 0.1 0.9 -0.1 0.5 0.3 0.8 1.3 1.1 0.4 1.2 0.6 0.6 -1.0
High cholesterol (Self-reported) 0.4 0.7 1.4 -0.8 0.8 0.6 -1.0 -0.8 -1.0 -0.9 -1.0 -0.4 -0.7 -0.9 -1.2 -0.8 -0.8 -0.9 0.8
Medication: Bendroflumethiazide 0.1 0.2 0.8 0.6 0.4 -0.2 -0.6 0.5 0.0 0.2 0.3 0.6 0.9 0.1 -0.0 0.3 0.5 0.1 -0.0
Medication: Paracetamol 0.5 0.7 1.2 -1.1 0.7 0.8 -0.9 -1.0 -1.0 -0.8 -1.1 -0.8 -0.4 -0.8 -0.9 -0.8 -1.1 -0.8 0.7
Medication: Lisinopril 0.1 0.1 1.3 0.1 0.2 0.1 -0.1 0.0 0.2 0.1 0.5 0.3 1.1 0.0 0.0 -0.1 0.1 0.2 -0.1
Medication: Atorvastatin 1.3 1.6 2.9 -1.3 1.6 1.6 -1.3 -1.3 -1.7 -1.0 -1.2 -1.1 -0.7 -1.3 -0.8 -1.3 -1.4 -1.1 1.3
Illnesses of father: High blood pressure 0.3 0.3 1.7 0.3 -0.9 -0.4 0.8 0.3 0.6 -0.1 0.7 0.6 1.3 0.2 0.4 0.3 0.5 0.2 -0.4
Alcohol drinker status: Never 3.0 3.6 4.2 -1.9 2.0 1.9 -2.0 -1.9 -2.1 -1.7 -2.0 -2.1 -1.9 -1.6 -1.7 -1.6 -2.0 -1.8 1.9
Ever smoked 0.2 0.3 0.8 0.6 -0.2 -0.3 0.4 0.8 0.2 0.3 0.5 0.5 0.9 0.5 0.4 0.8 0.4 0.6 -0.4
Basal metabolic rate 2.0 11.2 16.6 3.5 -4.0 -4.1 3.9 3.5 3.6 3.6 3.6 3.2 0.0 2.6 2.8 3.1 3.6 3.4 -3.1
Leg fat percentage (left) 0.1 0.3 2.8 0.2 -0.2 -0.7 -0.3 0.3 -0.3 0.1 -0.2 -0.0 -1.7 -0.3 -0.8 0.2 0.2 -0.2 0.2
Arm fat-free mass (left) 2.7 13.8 20.1 3.9 -4.3 -4.5 4.1 3.9 3.8 4.0 3.9 3.6 0.7 3.1 3.1 3.6 4.0 3.9 -3.6
Number of operations (self-reported) 1.1 1.7 2.5 1.2 -1.3 -1.3 1.6 1.3 1.1 1.2 1.5 1.2 1.1 1.1 1.3 1.3 1.1 1.5 -1.2
Average weekly beer plus cider intake 0.1 0.1 0.4 -0.2 0.7 0.4 -0.5 -0.2 -0.1 -0.2 -0.5 0.0 0.2 -0.5 0.1 -0.3 -0.4 -0.2 0.6
Irritability 1.3 2.1 9.3 1.1 -1.7 -1.7 1.3 1.1 1.6 1.3 1.2 0.8 3.0 1.1 1.6 1.1 1.2 0.9 -1.1
Risk taking 1.0 1.4 2.7 -1.4 1.0 1.2 -0.7 -1.4 -0.4 -1.5 -0.8 -1.3 0.3 -1.6 -0.8 -1.5 -1.4 -1.2 1.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.2 -0.8 -0.7 0.5 0.2 0.5 0.6 0.5 -0.1 -0.7 0.2 -0.2 0.2 0.3 0.2 -0.4
Fractured/broken bones in last 5 years 0.4 0.5 1.1 0.8 -0.4 -0.4 0.9 0.6 0.5 0.6 0.7 0.3 1.0 0.7 1.0 0.5 0.9 1.1 -0.6
Age started oral contraceptive pill 1.8 2.3 4.6 -1.5 1.6 1.5 -1.8 -1.4 -2.1 -1.6 -1.7 -1.0 -1.6 -1.1 -1.7 -1.2 -1.6 -1.5 1.1
Diastolic blood pressure, automated reading 0.4 1.2 4.7 1.3 -0.5 -1.2 -0.3 1.5 -0.0 0.9 0.4 1.2 2.2 1.2 0.5 1.6 1.1 0.8 -1.0
Ever depressed for a whole week 1.9 2.3 4.6 -1.4 1.6 1.3 -1.4 -1.3 -2.0 -1.5 -1.5 -2.1 -1.3 -1.4 -1.5 -1.4 -1.5 -1.5 1.6
Unable to work because of sickness or disability 0.2 0.3 1.6 -0.5 0.1 0.1 -0.1 -0.6 0.5 -0.1 -0.1 -1.2 0.1 -0.7 -0.2 -0.6 -0.5 -0.4 0.7
Commuting to job workplace: Cycle 0.1 0.1 0.6 -0.2 0.0 0.0 -0.3 -0.2 0.0 -0.1 -0.1 -0.8 -0.2 0.1 -0.2 -0.1 -0.2 -0.4 0.1
Myopia 0.1 0.1 0.4 -0.1 -0.4 -0.4 -0.0 -0.0 -0.0 0.4 -0.4 -0.6 -0.0 0.5 -0.1 0.4 -0.1 -0.1 -0.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 2.7 -0.1 -1.1 -0.2 1.5 -0.2 1.4 0.2 0.5 -0.4 -1.6 -0.0 0.6 -0.2 0.1 0.2 -0.1
Cholesterol lowering medication 0.4 0.5 1.9 0.6 -0.2 -0.7 0.3 0.5 0.7 0.9 0.7 1.4 1.3 0.0 0.9 0.1 0.7 0.8 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 0.6 -0.7 -0.6 0.7 0.5 0.6 0.6 0.4 0.5 -0.0 0.1 0.4 0.3 0.6 0.4 -0.3
Pain experienced in last month 4.6 7.6 10.3 -2.8 2.5 2.4 -3.0 -2.7 -2.9 -2.7 -2.8 -2.8 -3.2 -2.5 -3.1 -2.5 -2.8 -3.0 2.4
Supplements: Calcium 1.1 1.2 1.9 1.4 -0.5 -1.0 0.4 1.3 0.8 1.1 1.1 1.3 0.6 1.3 1.3 1.2 1.3 1.3 -1.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.5 0.0 0.7 0.3 -0.5 0.0 0.0 0.3 0.1 0.7 0.3 -0.1 0.6 -0.1 -0.0 0.4 0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.8 -0.0 0.9 0.6 -0.6 -0.1 -0.8 -0.4 -0.3 -0.1 0.2 -0.3 -0.1 -0.3 -0.1 -0.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.8 0.4 -0.6 -0.4 0.9 0.1 0.7 0.2 0.7 0.2 0.7 0.1 0.5 -0.3 0.5 0.5 -0.2
Heart disease (siblings) 1.3 1.6 3.0 1.2 -1.4 -1.2 1.6 1.1 0.9 1.3 1.3 1.3 1.4 1.0 1.3 0.9 1.3 1.7 -1.2
Alcohol drinker status: Previous 0.7 0.8 1.5 0.9 -0.9 -0.9 1.2 0.8 0.8 0.8 1.1 1.1 0.3 0.6 1.0 0.5 1.0 1.0 -0.7
Pack years of smoking 2.3 3.4 5.3 -1.8 2.0 2.3 -1.7 -1.9 -1.6 -1.8 -1.6 -1.7 -2.0 -2.0 -1.3 -2.0 -1.8 -1.8 2.0
Impedance of whole body 1.6 8.3 10.5 -3.1 3.1 3.2 -2.7 -3.1 -2.7 -3.2 -2.6 -2.7 -2.1 -2.8 -2.6 -3.0 -3.1 -2.9 2.9
Leg fat mass (left) 0.3 1.2 3.3 1.2 -1.4 -1.8 0.9 1.3 0.9 1.1 1.0 0.9 -1.4 0.6 0.1 1.1 1.3 0.8 -0.9
Arm predicted mass (left) 2.8 14.3 20.2 3.9 -4.3 -4.5 4.1 4.0 3.9 4.1 4.0 3.8 0.8 3.2 3.2 3.6 4.0 3.9 -3.6