Best TWAS P=9.48e-10 · Best GWAS P=1.2e-08 conditioned to 0.0305
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | C5 | 0.06 | 0.02 | lasso | 8 | 0.02 | 2.9e-02 | 5.5 | 5.5 | 4.6e-08 | -0.51 | 0.06 | 0.66 | FALSE |
| 2 | GTEx | Artery Tibial | TRAF1 | 0.04 | 0.05 | lasso | 2 | 0.03 | 1.2e-03 | 5.5 | 5.5 | 4.0e-08 | -0.68 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Mucosa | TRAF1 | 0.08 | 0.00 | lasso | 4 | 0.01 | 8.5e-02 | 5.6 | 5.4 | 5.8e-08 | -0.40 | 0.02 | 0.93 | FALSE |
| 4 | GTEx | Esophagus Muscularis | PHF19 | 0.16 | 0.06 | lasso | 8 | 0.07 | 3.1e-05 | 5.3 | -5.5 | 2.9e-08 | 0.52 | 0.03 | 0.95 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | TRAF1 | 0.11 | 0.09 | lasso | 5 | 0.09 | 1.4e-07 | 5.5 | 6.1 | 9.5e-10 | -0.67 | 0.01 | 0.99 | TRUE |
| 6 | METSIM | Adipose | PHF19 | 0.07 | 0.01 | bslmm | 374 | 0.01 | 2.3e-02 | 4.1 | -5.2 | 1.8e-07 | 0.39 | 0.30 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PHF19 | 0.03 | 0.03 | lasso | 2 | 0.02 | 3.6e-03 | 5.5 | -5.7 | 1.3e-08 | 0.68 | 0.01 | 0.88 | FALSE |