Best TWAS P=2.49e-08 · Best GWAS P=1.09e-07 conditioned to 0.456
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | NT5DC2 | 0.13 | 0.12 | enet | 11 | 0.08 | 9.9e-05 | -5.0 | -5.2 | 1.8e-07 | -0.87 | 0.03 | 0.95 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | RP5-966M1.6 | 0.16 | 0.07 | enet | 19 | 0.11 | 1.8e-04 | 5.0 | 5.6 | 2.5e-08 | 0.89 | 0.04 | 0.95 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | NEK4 | 0.04 | 0.05 | blup | 359 | 0.05 | 1.1e-06 | -5.0 | -5.4 | 5.1e-08 | -0.85 | 0.03 | 0.97 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | TMEM110 | 0.02 | 0.01 | blup | 321 | 0.02 | 9.7e-04 | 5.3 | 5.4 | 8.4e-08 | 0.85 | 0.04 | 0.89 | FALSE |
| 5 | YFS | Blood | GNL3 | 0.02 | 0.03 | enet | 11 | 0.03 | 2.9e-09 | 4.4 | -5.2 | 2.1e-07 | -0.76 | 0.30 | 0.67 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ITIH4 | 0.04 | 0.03 | blup | 53 | 0.03 | 7.4e-04 | 4.2 | 5.3 | 9.7e-08 | 0.88 | 0.04 | 0.79 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ITIH4 | 0.03 | 0.03 | lasso | 4 | 0.03 | 5.1e-03 | 5.3 | 5.4 | 5.7e-08 | 0.96 | 0.01 | 0.76 | FALSE |