Hub : Genes

RP5-1050D4.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.183	0.0520	8.5e-05	0.073	NA	0.074	NA	0.085	3.9e-06	NA	3.3e-06	NA	6.1e-07
2	GTEx	Heart Left Ventricle	0.187	0.0722	9.5e-03	-0.004	NA	-0.002	NA	0.001	5.6e-01	NA	4.6e-01	NA	2.8e-01
3	GTEx	Muscle Skeletal	0.215	0.0447	5.9e-09	0.121	NA	0.142	NA	0.127	6.4e-12	NA	8.4e-14	NA	2.1e-12
4	GTEx	Thyroid	0.070	0.0310	2.8e-03	0.081	NA	0.023	NA	0.028	8.4e-07	NA	6.7e-03	NA	2.8e-03
5	GTEx	Whole Blood	0.090	0.0280	1.2e-05	0.095	NA	0.093	NA	0.105	4.9e-09	NA	6.2e-09	NA	6.6e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	2.2	1.0	1.5	-0.7	0.7	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.2	-0.8	0.7	0.2	0.2
Depressed Affect (Nagel 2018)	0.6	1.2	2.7	-0.6	1.6	1.0	-0.3	-1.4
Depression (Nagel 2018)	1.9	2.8	6.8	1.2	0.8	2.3	-0.1	-2.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.6	0.6	1.3	-0.0	-0.0	0.4
Neuroticism (Nagel 2018)	0.8	1.9	4.5	-0.8	2.1	1.5	-0.8	-1.2
Schizophrenia (2018)	0.8	1.7	4.2	-1.0	-2.0	1.6	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.4	0.0	0.0	-0.5	-0.8
Worry (Nagel 2018)	1.0	2.2	5.9	-0.6	2.4	1.0	-0.5	-1.9
Alzheimer’s Disease (in mother)	1.8	2.1	4.3	-1.1	-0.5	0.7	2.1	2.1
Alzheimer’s Disease (in father)	3.1	3.3	15.9	-0.1	-0.3	0.4	4.0	0.6
Alzheimer’s Disease (including proxy)	6.6	9.6	31.4	-1.4	-0.7	0.4	5.6	3.7
Crohns Disease (2017)	0.7	1.5	3.1	-1.3	0.3	1.2	1.8	1.0
Irritable Bowel Disease (IBD)	0.9	2.3	4.1	-1.7	2.0	1.7	1.0	-0.7
Ulcerative Colitis (UC)	1.2	2.3	5.8	-1.1	2.4	0.7	-0.1	-2.0
Major Depression (MDD)	0.2	0.3	0.7	0.7	-0.3	0.0	-0.8	0.4
Reaction Time	0.9	1.8	4.2	1.6	-1.1	-0.2	2.0	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.8	0.6	-0.7	-1.5	-0.2	2.2
Breast Cancer	0.7	1.6	5.8	-0.7	-0.5	-1.1	-2.4	0.4
Ovarian Cancer	1.3	1.8	6.8	-0.2	0.3	-2.6	-0.4	1.4
Prostate Cancer	1.1	1.6	3.5	-0.9	-1.1	1.9	1.3	0.8
Age at First Birth	0.5	0.8	1.2	-1.1	0.8	-1.1	0.9	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.7	-0.1	-0.5	-1.7	0.9	1.4
Coronary Artery Disease (CAD)	1.4	1.7	4.3	-2.0	0.0	-0.3	-2.1	-0.3
Crohns Disease (2012)	0.6	1.0	1.8	-0.9	0.5	0.6	1.3	1.3
Mean Putamen Volume	0.4	0.4	1.3	1.1	-0.1	-0.4	0.8	0.1
Fasting Glucose	0.7	0.8	2.7	0.4	0.3	0.9	1.6	0.5
HbA1C	1.2	1.3	4.4	0.4	0.6	2.1	-0.9	0.9
HDL Cholesterol	0.3	0.5	1.0	-0.9	-0.6	-1.0	0.4	0.6
LDL Cholesterol	0.6	1.0	3.2	-1.8	0.9	0.7	-0.4	-0.5
Lupus	0.7	1.0	2.2	0.1	1.1	0.4	-1.5	1.2
Neuroticism (2016)	1.0	1.4	3.4	0.6	1.9	-0.3	-0.1	-1.7
Primary Biliary Cirrhosis	1.1	1.6	3.2	0.8	0.9	1.3	-1.8	-1.2
Rheumatoid Arthritis	0.4	0.5	0.8	0.7	0.6	0.9	-0.3	0.9
Schizophrenia (2014)	0.8	1.7	3.7	-0.7	-1.7	1.9	-0.9	-0.7
Triglycerides	0.1	0.2	0.5	0.5	0.7	0.3	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.6	0.5	0.9	0.0	0.5
Ulcerative Colitis	0.9	1.3	3.7	-0.7	1.3	0.4	0.4	-1.9
Blood Eosinophil Count	0.8	6.1	10.9	-0.0	-3.3	0.5	3.3	3.0
Blood Platelet Count	4.1	48.0	198.8	14.1	-0.3	-1.2	4.0	-4.9
Blood Red Count	1.3	12.9	22.6	-3.6	-1.1	-3.6	3.9	4.8
Blood White Count	2.7	19.8	46.1	0.9	0.4	-2.6	6.8	6.7
Heel T-Score	0.7	5.5	13.0	-2.3	-0.4	0.4	3.6	3.0
BMI	1.3	7.7	22.7	-1.4	1.6	-0.4	3.4	4.8
Height	0.2	3.9	8.2	-0.8	2.2	-2.9	-0.0	-2.4
Waist Hip Ratio (WHR)	1.1	4.8	16.1	-4.0	2.0	-0.7	1.1	1.4
Systolic Blood Pressure	0.5	2.4	6.5	-2.5	0.1	-0.9	0.1	2.2
Smoking Status	1.1	2.7	6.3	-1.4	1.3	2.5	1.4	1.3
Allergy or Eczema	0.4	1.0	2.1	1.0	1.1	0.7	1.4	0.2
Cardiovascular Disease	0.8	2.7	9.3	-1.6	1.1	0.1	-0.5	3.0
Hypothyroidism (self reported)	0.9	2.1	5.1	2.3	0.1	-1.2	-1.8	0.8
Respiratory disease	0.6	1.4	4.0	2.0	1.1	0.4	-0.8	-1.0
Type 2 Diabetes (T2D) (2018)	2.0	3.7	13.1	-1.4	0.8	-0.5	1.6	3.6
Lung FEV1/FVC ratio	0.4	2.2	3.7	-1.7	-0.4	0.9	1.9	1.9
Lung FVC	0.2	0.9	2.6	1.1	0.3	0.4	0.7	1.6
Neuroticism	0.9	2.1	6.2	-1.2	2.5	1.6	0.0	-0.7
Chronotype (morning person)	1.3	3.0	4.8	1.9	0.5	1.6	-1.8	-2.2
Hair Pigment	0.0	1.1	2.3	-0.9	-0.1	1.1	-1.5	1.1
Tanning	0.1	0.8	2.4	-0.0	0.9	-0.7	1.5	0.6
Hand grip strength (left)	1.0	2.5	10.7	-0.3	0.3	-1.1	3.3	0.7
Number of treatments/medications taken	0.9	1.6	4.6	2.1	-0.1	0.1	-1.6	0.9
Average weekly spirits intake	1.3	1.6	4.2	2.1	0.3	1.8	0.7	-0.2
Sensitivity / hurt feelings	0.8	1.4	3.8	0.3	2.0	1.1	-1.0	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.0	0.0	0.5	1.4	0.1	-1.2
Hearing difficulty/problems: Yes	2.6	4.0	6.5	1.1	2.6	2.1	-1.6	-2.3
Relative age of first facial hair	0.3	0.7	1.7	-1.3	0.7	0.3	-0.9	0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.1	1.8	-0.0	0.5	0.7	1.4
Ever used hormone-replacement therapy (HRT)	2.6	3.2	10.1	0.4	1.5	3.2	-1.7	-1.0
Ever had hysterectomy (womb removed)	0.7	0.8	2.1	1.0	-0.1	0.0	-1.5	-0.9
Systolic blood pressure, automated reading	0.5	1.5	4.1	-1.2	0.2	1.3	-0.5	2.0
Eye problems/disorders: Diabetes related eye disease	3.9	4.3	9.2	-0.6	1.2	-2.8	1.6	3.0
Angina	0.2	0.2	0.5	0.6	0.7	-0.1	-0.6	0.2
Medication for hormone replacement therapy	0.6	0.6	0.8	0.8	-0.8	-0.9	-0.8	0.7
Vitamin and mineral supplements	1.9	2.5	8.8	-1.5	-0.5	-0.8	0.8	3.0
Supplements: Zinc	1.0	1.1	3.4	1.8	-0.5	0.5	-0.2	-1.3
Medication: Co-codamol	1.1	1.2	4.2	1.1	0.2	0.9	0.1	-2.0
Medication: Metformin	1.1	1.6	5.1	0.5	1.1	-0.8	0.9	2.3
Diabetes (father)	1.3	1.6	6.1	-0.9	-0.6	-2.5	0.1	0.9
Diabetes (mother)	0.1	0.1	0.5	0.0	-0.0	-0.3	0.1	-0.7
Severe depression (siblings)	0.6	0.6	2.0	0.0	1.4	-0.8	0.6	0.5
Pack years adult smoking proportion	1.0	1.5	5.0	-1.1	2.2	0.5	-0.7	0.7
Impedance of leg (right)	0.3	1.5	5.8	-0.0	-0.2	-0.6	-1.1	-2.4
Leg fat-free mass (left)	0.7	3.8	10.4	-1.0	0.6	-0.7	3.2	2.6
Trunk fat percentage	0.8	3.1	10.1	-0.1	0.6	-0.9	2.0	3.2
Hand grip strength (right)	1.2	3.3	14.9	-0.1	-0.4	-0.9	3.9	0.7
Townsend deprivation index at recruitment	1.1	1.6	6.0	-2.4	0.5	-0.6	-0.1	1.2
Current tobacco smoking	0.4	0.7	3.2	0.1	0.3	1.8	0.4	0.4
Average weekly fortified wine intake	1.5	1.7	5.9	2.4	-0.4	-1.0	0.9	-0.8
Maternal smoking around birth	0.9	1.3	3.3	-1.6	-0.2	0.8	-0.1	1.8
Fed-up feelings	0.9	1.7	6.6	-2.6	0.4	0.3	1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	4.2	0.3	-0.2	2.0	0.7	-1.5
Relative age voice broke	0.7	1.0	4.4	-2.1	0.1	-0.1	-0.0	0.8
Taking other prescription medications	2.1	3.2	9.7	2.3	-0.9	0.7	-3.1	0.2
Age when periods started (menarche)	1.2	2.8	6.4	-2.1	1.1	1.0	-2.5	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.6	0.1	-0.4	1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.3	-2.1	-1.0	0.4	1.9	1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.2	0.3	-2.0	-0.9	0.8	0.7
Qualifications: CSEs or equivalent	1.1	1.4	4.5	-0.3	0.6	-1.4	0.5	2.1
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.2	0.3	0.9	0.6	1.3
High blood pressure	0.4	1.1	3.2	0.3	1.0	0.7	-1.8	0.7
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.2	2.1	0.7	0.9	0.9	-0.1
Multivitamins +/- minerals	2.5	3.1	10.0	2.1	0.6	0.8	-0.2	-3.2
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.4	0.4	-0.1	-0.3	0.5
Supplements: Glucosamine	0.7	0.9	3.3	1.8	0.5	-0.3	-0.0	-1.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.7	0.9	0.4	-1.9	0.1	1.1
Medication: Atenolol	0.5	0.6	2.6	0.3	0.2	0.0	-0.7	-1.6
Medication: Levothyroxine sodium	1.2	2.0	5.3	2.3	0.5	-1.4	-1.4	0.7
Sitting height	0.1	0.6	1.8	-0.7	0.1	-0.1	1.3	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.5	1.4	1.2	0.1	-0.1	-0.2	-1.1
High blood pressure (mother)	0.8	1.1	2.4	1.5	-0.5	1.5	-0.4	-0.6
Body mass index (BMI)	1.3	5.5	16.0	-0.7	1.6	0.2	2.8	4.0
Impedance of leg (left)	0.3	1.4	5.0	0.1	-0.5	-0.6	-1.2	-2.2
Leg predicted mass (left)	0.8	4.1	10.8	-1.1	0.6	-0.6	3.3	2.8
Trunk fat mass	0.9	3.9	10.8	-0.5	0.8	-0.8	2.7	3.3
Waist circumference	1.3	4.9	13.5	-1.5	1.4	-0.2	2.6	3.7
Number of incorrect matches in round	1.4	2.4	4.6	1.4	-1.5	1.6	-0.7	-2.1
Past tobacco smoking	0.8	1.6	3.1	1.1	-1.5	-1.7	-0.6	-0.9
Alcohol usually taken with meals	1.0	1.6	4.4	1.4	0.7	-1.1	-0.2	-2.1
Nervous feelings	0.8	1.5	3.9	0.2	0.5	0.5	-2.0	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.8	0.5	0.4	-0.0	-0.5	-1.7
Hearing difficulty/problems with background noise	0.8	1.2	3.7	0.1	1.0	1.9	-0.7	-1.0
Hair/balding pattern: Pattern 2	1.1	1.4	2.2	-1.3	-1.2	0.9	1.0	1.5
Had menopause	1.9	2.4	6.8	1.5	0.0	1.4	-2.6	-1.0
Had other major operations	1.4	1.7	4.8	0.5	2.2	1.1	-0.8	-1.3
Forced vital capacity (FVC)	0.7	2.9	8.0	-1.7	-1.1	-0.4	2.8	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.8	-1.9	-0.7	0.9	1.9	0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.2	-1.8	-0.9	-1.4	0.4	0.6
Qualifications: None of the above	1.7	3.6	11.5	0.1	-2.4	0.4	-3.4	-0.9
Financial difficulties in last 2 years	0.6	0.8	3.5	-0.3	-0.0	-0.5	1.9	0.4
Mouth/teeth dental problems	1.5	2.3	3.4	-1.8	-1.5	-1.8	0.9	1.3
Heart attack	0.4	0.5	1.1	0.5	0.3	-1.0	-1.1	0.4
Allergy	1.4	3.2	13.6	-3.7	-0.8	-0.7	-0.4	1.0
Pain all over the body in last month	1.0	1.1	3.2	1.8	-0.2	-0.2	1.5	0.3
Diabetes (self-reported)	2.8	4.4	12.7	-1.1	1.2	-2.1	1.4	3.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	1.2	-0.8	-0.9	0.1	0.5
Medication: Ramipril	0.7	0.9	2.3	1.2	0.8	-0.1	-1.5	0.1
Medication: Simvastatin	0.6	0.9	3.1	-0.2	1.1	-0.1	-1.8	0.0
Fluid intelligence score	0.7	1.4	3.4	-0.2	-0.3	-0.9	1.6	1.8
Illnesses of siblings	2.1	2.9	10.7	-1.7	-0.5	0.3	3.3	0.8
Neuroticism score	1.1	2.4	6.0	-2.0	2.4	0.8	0.9	0.4
Weight	0.9	4.4	10.0	-1.1	1.1	-0.6	3.2	3.1
Impedance of arm (right)	0.9	4.3	8.0	1.3	-2.8	-1.7	-1.9	-2.3
Arm fat percentage (right)	1.3	5.0	16.5	-0.3	0.2	-1.0	2.7	4.1
Trunk fat-free mass	0.6	3.5	11.3	-1.6	0.7	-0.3	3.4	1.8
Hip circumference	0.8	3.7	10.6	-0.2	0.4	-0.5	2.7	3.3
Time employed in main current job	1.4	1.6	3.6	-1.8	0.3	1.9	0.8	0.9
Alcohol intake versus 10 years previously	0.7	1.0	1.9	-1.4	1.4	-0.6	-0.7	0.9
Father’s age at death	0.4	0.5	0.8	-0.9	0.6	0.1	0.7	-0.9
Worrier / anxious feelings	0.8	1.5	4.6	-0.9	2.1	1.1	0.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.4	-0.8	0.5	-0.4	-0.7
Falls in the last year	1.2	1.7	4.1	1.3	0.3	1.4	-2.0	-0.8
Hair/balding pattern: Pattern 3	0.7	1.0	2.4	-0.4	1.3	-1.6	1.0	0.2
Number of live births	1.1	1.6	3.0	-1.6	-0.4	-0.9	-1.1	1.7
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	11.8	-2.5	-1.6	-0.5	3.4	2.2
Pulse rate	0.9	1.5	2.8	0.5	1.3	1.7	0.0	-1.6
Happiness	0.8	1.0	3.4	-0.7	0.1	0.1	-1.8	-1.1
Noisy workplace	0.9	1.1	2.0	-0.5	-1.4	-1.3	-1.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-0.5	1.2	0.1	1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.5	-1.5	-0.4	0.9	1.9	1.3
Mouth/teeth dental problems: Dentures	3.0	5.0	14.4	3.8	0.2	2.2	-1.4	-1.9
Asthma	0.5	0.9	4.1	2.0	0.0	0.2	-0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.4	-0.2	-1.2	0.8	1.9	0.1
Medication: Cholesterol lowering	0.9	1.4	2.6	0.9	1.6	-0.9	-1.2	1.1
Depression (self-reported)	0.9	1.1	2.5	0.5	-1.6	0.7	1.4	-0.6
Medication: Lansoprazole	0.3	0.3	1.1	-0.4	-1.0	-0.3	-0.4	-0.4
Prospective memory result	3.7	4.5	9.2	-0.1	0.9	3.0	-2.9	-2.1
Lung cancer (father)	2.4	2.9	10.5	-1.2	-0.7	3.2	0.2	-1.3
Illnesses of mother	0.4	0.5	1.3	-0.8	0.2	-0.6	1.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.2	-2.1	-1.5	-1.3	2.3	1.9
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	0.4	0.2	0.1	0.2
Impedance of arm (left)	0.9	4.2	6.3	1.4	-2.5	-1.2	-2.3	-2.5
Arm fat mass (right)	1.2	5.1	14.6	-0.7	0.6	-0.8	3.1	3.8
Trunk predicted mass	0.6	3.3	10.8	-1.6	0.6	-0.2	3.3	1.7
Standing height	0.2	1.7	2.9	-0.7	-0.9	-1.7	1.4	-1.5
Length of working week for main job	0.2	0.3	0.9	0.1	0.4	0.9	0.5	0.1
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.2	-1.0	-0.1	-0.4	-0.6
Breastfed as a baby	0.9	1.2	2.7	1.1	1.6	0.1	-0.7	-1.2
Tense / ‘highly strung’	1.8	3.0	7.0	-0.7	2.6	2.2	-0.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	1.1	-0.2	-0.8	0.6	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	3.4	0.3	0.4	1.2	-1.8	-0.3
Birth weight of first child	0.2	0.4	0.6	0.7	0.8	-0.3	-0.1	-0.8
Peak expiratory flow (PEF)	0.9	2.2	6.9	-1.6	0.6	-0.2	2.6	1.1
Pulse wave reflection index	0.2	0.2	0.4	0.4	0.5	0.3	0.2	0.6
Ever highly irritable/argumentative for 2 days	2.2	2.6	5.8	-2.4	-0.3	-1.5	1.5	1.6
Loud music exposure frequency	1.4	1.5	2.4	-1.6	-1.0	-1.2	-0.7	1.5
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	12.7	-0.3	0.6	-2.4	3.6	1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	0.6	-0.1	-0.7	0.0
Blood clot in the leg (DVT)	0.3	0.4	1.3	1.1	0.2	0.3	0.9	0.1
Medication: Paracetamol	1.3	2.1	5.7	-1.0	0.7	-0.6	1.7	2.4
Headache pain in last month	0.9	1.5	4.8	-0.5	-2.2	1.5	-0.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	-0.9	-1.3	-0.6	1.5	-0.1
Glaucoma (self-reported)	0.7	0.8	1.8	-0.7	-1.4	0.4	0.7	1.0
Gout (self-reported)	0.5	0.7	2.7	-0.1	0.7	-1.6	-0.4	0.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.2	2.5	0.1	-1.4	-1.6	0.9
Medication: Amlodipine	1.1	1.5	3.8	-0.3	-0.3	2.0	-1.4	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.4	-0.4	0.8	-1.2	-0.1
Birth weight	0.6	1.4	3.3	0.2	0.4	0.2	1.8	-1.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.5	-0.5	0.2	-1.9	-0.5	1.3
High blood pressure (siblings)	1.7	2.4	8.4	1.2	1.4	-0.7	-2.9	0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	3.1	-1.4	-1.0	-0.4	1.8	0.6
Body fat percentage	0.9	3.7	12.0	-0.2	0.8	-0.5	2.3	3.5
Leg fat percentage (right)	1.3	4.6	11.3	-0.3	2.1	0.3	2.7	3.4
Arm fat-free mass (right)	0.8	4.0	9.7	-1.8	1.3	0.4	3.1	2.3
Exposure to tobacco smoke outside home	0.4	0.5	1.8	-0.4	0.6	1.3	0.4	0.4
Comparative body size at age 10	0.3	0.9	1.8	1.4	0.9	0.0	-0.4	-1.3
Number of full brothers	0.9	1.1	5.4	0.2	-2.3	-0.0	0.1	-0.1
Worry too long after embarrassment	0.7	1.2	2.8	-1.6	1.7	-0.5	-0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.8	0.4	0.0	1.3	-0.3
Wheeze or whistling in the chest in last year	1.0	1.7	2.9	0.5	1.0	1.7	-1.7	-1.4
Number of children fathered	2.3	2.6	6.5	-0.8	-0.4	1.0	2.6	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.1	0.8	-0.7	-0.3	-0.4
Age at first live birth	0.9	1.6	5.2	-2.3	0.5	0.9	1.2	0.2
Pulse wave peak to peak time	0.1	0.1	0.3	-0.0	-0.5	-0.5	-0.0	-0.3
Health satisfaction	2.8	3.6	7.7	0.9	1.2	2.0	-2.0	-2.8
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.1	-0.6	0.7	-0.3	0.2
Qualifications: College or University degree	0.1	0.4	0.7	-0.1	-0.9	0.5	0.6	-0.7
Eye problems/disorders: None of the above	0.3	0.3	1.5	0.0	-0.1	-0.2	0.2	-1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	1.2	-0.0	0.3	-0.1	-1.0
Emphysema/chronic bronchitis	0.4	0.5	1.2	1.0	1.1	0.2	0.1	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	0.1	-1.0	-0.5	0.3	-1.0
Neck or shoulder pain in last month	0.7	1.1	2.6	1.1	0.7	-0.0	-1.6	-0.9
Medication: Blood pressure	0.4	0.7	2.4	0.1	0.6	0.9	-1.5	0.0
Angina (self-reported)	0.2	0.2	0.4	0.5	0.4	-0.5	-0.6	0.3
Migraine (self-reported)	0.4	0.5	1.1	0.6	-0.7	0.6	0.6	-1.1
Medication: Ibuprofen	0.7	0.9	2.6	-0.6	-0.9	0.5	1.6	0.6
Medication: Allopurinol	0.9	1.2	2.0	-1.4	0.7	-1.2	-1.0	0.9
Medication: Omeprazole	0.2	0.3	0.5	-0.4	0.7	0.4	-0.6	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	2.8	1.7	-0.4	-0.3	-1.0	-0.2
Mean time to correctly identify matches	1.0	1.9	5.6	2.4	0.2	0.5	0.5	-1.8
Heart disease (mother)	0.6	0.7	2.8	-0.4	0.4	-0.3	-1.7	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.1	0.8	-0.8	-0.8	0.4
Whole body fat mass	0.9	3.7	10.4	-0.5	1.1	-0.5	2.6	3.2
Leg fat mass (right)	1.5	5.9	14.7	-0.7	1.7	-0.1	3.3	3.8
Arm predicted mass (right)	0.7	3.5	8.8	-1.4	1.5	0.2	3.0	2.1
Pulse rate, automated reading	1.4	4.6	13.2	1.6	2.1	0.7	-1.5	-3.6
Alcohol intake frequency.	1.4	3.2	6.6	-2.0	-1.3	-2.6	-0.9	1.7
Comparative height size at age 10	0.2	1.2	3.5	0.3	-1.1	-0.9	0.8	-1.9
Number of full sisters	0.5	0.7	1.2	0.6	0.9	-0.8	-1.1	-0.4
Suffer from ‘nerves’	0.7	1.1	4.5	-2.1	0.6	0.0	0.7	-0.4
Overall health rating	1.5	3.2	8.8	1.6	-0.6	1.3	-3.0	-1.7
Chest pain or discomfort	0.1	0.1	0.5	-0.2	0.7	0.1	0.2	-0.1
Had major operations	0.3	0.4	1.0	0.8	0.4	0.2	-1.0	-0.4
Age at last live birth	2.2	3.2	9.7	-3.1	-0.5	1.8	1.4	1.0
Family relationship satisfaction	0.6	0.8	1.6	0.8	-0.7	-0.1	-1.0	-1.3
Leg pain on walking	0.4	0.5	1.1	0.8	0.7	0.5	-1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	3.3	-0.2	1.3	0.6	1.8	0.9
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.5	-1.0	-0.5	0.2	1.2	2.1
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	6.8	0.9	0.4	-0.5	-2.6	-2.0
Medication: Aspirin	2.0	2.6	6.9	0.3	2.6	1.3	-2.0	-0.7
Supplements: Vitamin C	0.4	0.4	0.7	0.6	0.9	0.5	-0.5	-0.8
Knee pain experienced in last month	0.2	0.4	1.2	-0.5	1.1	0.3	-0.5	0.1
Hypertension (Self-reported)	0.4	1.1	1.8	0.1	1.3	0.7	-1.2	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-0.2	1.1	0.7	-0.8	-0.2
Illnesses of father: Heart disease	1.3	1.8	4.0	0.7	1.9	0.7	-2.0	-0.6
Illnesses of siblings: Diabetes	1.4	1.7	5.3	1.2	0.8	-1.1	-2.3	-0.3
Smoking status: Previous	0.7	1.1	2.8	-0.9	1.7	0.9	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.5	0.2	-1.8	-1.9	1.2	-0.4
Whole body fat-free mass	0.7	4.0	11.6	-1.5	0.7	-0.3	3.4	2.3
Leg fat-free mass (right)	0.7	3.9	10.6	-1.0	0.4	-0.7	3.2	2.7
Arm fat percentage (left)	1.1	4.3	14.5	-0.2	0.4	-0.7	2.5	3.8
Average weekly red wine intake	2.0	2.9	5.7	2.4	2.2	-0.7	0.5	-1.8
Handedness (chirality/laterality): Left-handed	1.7	2.1	7.8	0.8	-2.8	0.1	-1.3	-0.5
Mood swings	1.0	1.8	5.0	-2.2	0.8	1.0	1.5	-0.3
Loneliness, isolation	0.4	0.5	1.6	-1.3	0.4	-0.8	-0.2	-0.2
Long-standing illness, disability or infirmity	1.1	1.8	3.1	1.8	-0.0	1.4	-1.7	-0.9
Ever had bowel cancer screening	4.1	4.8	13.6	1.6	1.7	2.0	-3.7	-1.0
Diabetes diagnosed by doctor	2.4	3.9	12.0	-0.8	1.3	-1.9	1.2	3.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	5.6	1.9	0.2	0.9	-1.1	-2.4
Friendships satisfaction	0.7	0.9	2.3	0.2	-0.4	0.7	-1.2	-1.5
Qualifications: nursing, teaching	2.2	3.4	12.8	1.5	3.6	0.8	0.6	-1.0
Commuting to job workplace: Walk	2.1	2.3	7.7	0.7	-0.7	-1.4	-2.8	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.6	-0.1	1.3	0.6	-1.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.9	-0.9	1.3	1.4	-0.1	0.1
Medication for cholesterol	0.3	0.5	1.4	0.8	0.3	0.3	0.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	0.5	0.2	1.2	-0.5	-0.8
Back pain experienced in last month	0.6	0.9	2.1	0.5	-1.3	-0.7	-1.4	0.3
Mineral and other dietary supplements	2.5	3.3	8.4	-2.9	-1.5	0.7	0.2	2.4
Breast cancer (self-reported)	1.0	1.2	4.8	-1.1	2.2	0.3	-0.2	-0.1
Asthma (self-reported)	0.5	1.0	4.4	2.1	-0.0	0.2	-0.7	-0.3
Osteoporosis (self-reported)	1.9	2.3	9.8	1.0	-0.2	-0.3	-3.1	-0.8
Osteoarthritis (self-reported)	0.5	0.6	0.9	0.8	-0.1	0.7	-0.9	1.0
Medication: Aspirin	1.4	1.9	4.4	0.3	2.1	1.3	-1.7	-0.4
Medication: Gliclazide	0.6	0.7	2.9	1.7	-0.3	0.0	-0.8	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.0	0.2	-0.9	0.8	-0.5
Smoking status: Current	0.5	0.7	3.2	0.2	0.2	1.8	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	-0.9	0.2	1.0	0.8	0.7
Whole body water mass	0.7	3.9	11.4	-1.4	0.7	-0.3	3.4	2.3
Leg predicted mass (right)	0.8	4.2	11.4	-1.1	0.3	-0.7	3.4	2.8
Arm fat mass (left)	1.2	4.8	14.0	-0.6	0.7	-0.6	3.0	3.7
Number of self-reported non-cancer illnesses	0.9	1.6	5.3	2.3	1.2	0.3	-0.9	0.6
Average weekly champagne plus white wine intake	1.2	1.6	2.8	0.3	-1.2	1.1	-1.7	-1.5
Miserableness	0.1	0.2	0.3	-0.6	0.1	-0.3	-0.3	-0.5
Guilty feelings	0.2	0.4	0.6	-0.8	0.5	-0.8	0.2	0.6
Wears glasses or contact lenses	1.9	2.2	7.3	2.7	-0.6	0.4	-0.6	-1.7
Ever taken oral contraceptive pill	2.4	2.6	7.1	-1.1	0.7	-0.7	2.7	1.9
Hearing aid user	1.5	1.7	3.7	1.9	-1.1	-0.8	-1.3	-1.1
Mother’s age at death	0.2	0.3	0.8	0.9	-0.7	-0.1	-0.1	-0.1
Financial situation satisfaction	1.4	1.7	5.6	0.0	1.6	0.6	0.1	-2.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.7	0.8	-0.5	-0.3	-0.5
Commuting to job workplace: Public transport	0.8	0.9	2.1	1.4	0.9	0.9	-0.5	-0.9
Eye problems/disorders: Glaucoma	0.8	1.0	2.5	-1.0	-1.6	0.5	0.5	1.0
Medication: Blood pressure	0.4	0.7	2.0	-0.2	1.0	0.7	-1.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.7	0.5	1.6	-0.9	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.9	3.0	2.4	0.2	-0.7	-2.4
High cholesterol (Self-reported)	0.8	1.4	3.3	-0.8	1.5	-0.2	-0.8	1.8
Medication: Bendroflumethiazide	0.9	1.4	5.0	-0.1	1.0	0.6	-2.2	-0.6
Medication: Paracetamol	0.9	1.4	2.8	-0.7	0.8	-0.3	1.7	1.7
Medication: Lisinopril	0.7	0.9	3.0	-0.9	1.7	0.4	0.4	0.8
Medication: Atorvastatin	0.5	0.7	1.1	0.3	1.0	-0.4	-1.0	1.1
Illnesses of father: High blood pressure	0.8	1.0	4.2	-0.0	0.9	-0.3	-2.0	-0.4
Alcohol drinker status: Never	0.9	1.1	2.7	1.6	-0.5	-1.3	-0.8	-0.4
Ever smoked	1.1	1.9	4.2	-0.8	1.7	2.0	0.8	1.1
Basal metabolic rate	0.8	4.7	12.9	-1.5	0.6	-0.6	3.6	2.7
Leg fat percentage (left)	1.3	4.6	11.8	-0.3	2.0	0.5	2.6	3.4
Arm fat-free mass (left)	0.9	4.6	12.0	-1.8	1.1	0.2	3.5	2.6
Number of operations (self-reported)	0.5	0.8	2.4	0.3	1.6	0.7	-0.8	-0.1
Average weekly beer plus cider intake	1.0	1.4	2.2	-1.0	1.3	-0.4	1.5	1.3
Irritability	2.4	4.0	7.0	-2.2	1.6	0.9	2.6	2.2
Risk taking	1.3	1.9	5.3	-0.9	1.6	2.3	0.5	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.5	-0.9	1.0	0.5	-0.1
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.1	-0.5	-0.2	-0.8	0.8
Age started oral contraceptive pill	2.3	2.9	5.0	-1.8	1.5	1.5	-2.2	-1.3
Diastolic blood pressure, automated reading	0.3	1.0	3.7	-0.8	0.8	0.1	-0.5	1.9
Ever depressed for a whole week	0.5	0.7	1.5	-1.2	-0.5	-0.8	-0.1	1.0
Unable to work because of sickness or disability	0.6	0.8	1.3	-0.0	-1.1	-1.1	0.5	1.1
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.4	-0.1	-1.0	-0.9	-0.1
Myopia	1.3	1.8	4.4	0.8	-0.2	0.9	-1.8	-2.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	0.0	-0.9	-0.6	1.6	-1.1
Cholesterol lowering medication	0.8	1.1	3.1	-1.8	0.9	0.8	-0.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-1.0	0.6	0.4	-0.5	-0.3
Pain experienced in last month	0.8	1.3	4.5	0.6	-0.1	-1.1	2.1	0.5
Supplements: Calcium	0.4	0.5	1.1	0.1	0.4	-0.3	-1.1	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.8	0.7	0.3	1.5	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	0.7	0.2	-0.8	-1.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	1.0	0.2	0.3	0.9	0.4
Heart disease (siblings)	1.1	1.3	2.6	1.5	-1.2	0.3	-1.6	0.0
Alcohol drinker status: Previous	1.8	2.1	3.9	-1.7	0.0	-2.0	0.7	1.7
Pack years of smoking	0.8	1.2	4.0	-0.9	2.0	0.4	-0.8	0.6
Impedance of whole body	0.6	3.0	7.4	0.7	-1.8	-0.7	-1.9	-2.7
Leg fat mass (left)	1.4	5.3	13.5	-0.7	1.6	0.1	3.2	3.7
Arm predicted mass (left)	1.0	5.3	12.5	-2.1	1.3	0.2	3.5	2.8