[Hub]/) : Traits : Alzheimer’s Disease (including proxy) : ← →

chr16:30,154,740-31,860,399

Best TWAS P=2.67e-10 · Best GWAS P=3.24e-08 conditioned to 0.198

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KAT8	0.06	0.07	lasso	1	0.07	3.9e-09	5.2	-5.2	1.6e-07	0.50	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	-5.3	-6.0	2.2e-09	0.89	0.02	0.98	FALSE
3	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	5.3	-5.6	2.2e-08	0.49	0.03	0.90	FALSE
4	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	5.2	-6.0	1.8e-09	0.73	0.03	0.97	FALSE
5	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	-5.3	-6.1	1.1e-09	0.89	0.02	0.98	FALSE
6	GTEx	Brain Caudate basal ganglia	PRSS36	0.16	0.25	lasso	3	0.23	2.4e-07	-5.3	-5.4	8.3e-08	0.97	0.02	0.94	FALSE
7	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	5.2	-5.3	1.4e-07	0.51	0.03	0.86	FALSE
8	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	5.3	-6.1	1.1e-09	0.79	0.04	0.87	FALSE
9	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	4.5	-5.2	1.9e-07	0.45	0.04	0.82	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	5.3	-6.1	1.1e-09	0.83	0.03	0.83	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	PRSS36	0.40	0.28	lasso	2	0.26	1.6e-07	-5.3	-5.3	1.1e-07	0.97	0.02	0.96	FALSE
12	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	5.3	-6.1	1.2e-09	0.80	0.03	0.97	FALSE
13	GTEx	Cells Transformed fibroblasts	KAT8	0.31	0.31	lasso	4	0.32	1.9e-24	-5.3	-5.7	1.2e-08	0.96	0.02	0.98	FALSE
14	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	5.2	-6.1	1.4e-09	0.83	0.02	0.91	FALSE
15	GTEx	Colon Transverse	KAT8	0.14	0.12	lasso	6	0.05	1.4e-03	-5.3	-5.9	2.9e-09	0.94	0.02	0.94	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-5.3	-5.9	4.0e-09	0.82	0.04	0.95	FALSE
17	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	-5.3	-6.2	5.5e-10	0.87	0.02	0.98	FALSE
18	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	-5.3	-6.1	1.4e-09	0.90	0.02	0.98	FALSE
19	GTEx	Heart Atrial Appendage	KAT8	0.12	0.02	lasso	4	0.01	1.6e-01	5.2	-5.1	2.7e-07	0.56	0.04	0.67	FALSE
20	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	5.0	-5.2	1.5e-07	0.42	0.03	0.88	FALSE
21	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	5.3	-5.4	6.8e-08	0.45	0.02	0.97	FALSE
22	GTEx	Liver	PRSS36	0.13	0.03	enet	34	0.04	2.2e-02	-5.2	-5.6	2.6e-08	0.67	0.04	0.56	FALSE
23	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	5.3	-6.2	7.7e-10	0.83	0.02	0.98	FALSE
24	GTEx	Muscle Skeletal	KAT8	0.08	0.04	enet	16	0.06	1.4e-06	-4.9	-5.7	1.0e-08	0.89	0.05	0.95	FALSE
25	GTEx	Nerve Tibial	KAT8	0.17	0.06	enet	24	0.08	3.0e-06	-5.3	-5.9	4.4e-09	0.78	0.02	0.98	FALSE
26	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	5.2	-6.0	2.3e-09	0.74	0.03	0.81	FALSE
27	GTEx	Pituitary	KAT8	0.18	0.10	lasso	3	0.13	4.4e-04	-5.3	-5.4	7.8e-08	0.97	0.02	0.93	FALSE
28	GTEx	Pituitary	C16orf93	0.10	0.00	enet	14	0.00	2.4e-01	-3.7	5.7	1.5e-08	-0.54	0.04	0.31	FALSE
29	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	5.2	-5.7	1.3e-08	0.66	0.03	0.68	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	-5.3	-6.0	2.4e-09	0.86	0.02	0.98	FALSE
31	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	5.3	-6.0	1.5e-09	0.84	0.02	0.98	FALSE
32	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	-5.3	-6.2	4.4e-10	0.85	0.04	0.94	FALSE
33	GTEx	Thyroid	STX1B	0.11	0.16	enet	19	0.16	3.9e-12	-4.3	-5.2	1.9e-07	0.63	0.68	0.29	FALSE
34	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	5.1	-6.0	2.7e-09	0.80	0.03	0.97	FALSE
35	GTEx	Vagina	KAT8	0.34	0.26	lasso	5	0.22	8.4e-06	-5.3	-5.4	8.1e-08	0.97	0.02	0.84	FALSE
36	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	5.1	5.2	1.5e-07	-0.46	0.02	0.97	FALSE
37	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	5.1	5.7	1.2e-08	-0.72	0.03	0.97	FALSE
38	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	5.1	-6.1	1.2e-09	0.86	0.02	0.98	FALSE
39	NTR	Blood	BCKDK	0.01	0.00	bslmm	242	0.01	2.5e-03	5.2	5.4	8.5e-08	-0.52	0.03	0.92	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	-2.7	-5.5	4.9e-08	0.75	0.11	0.71	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	5.3	-5.9	3.3e-09	0.70	0.03	0.97	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	PRSS36	0.14	0.12	bslmm	241	0.12	1.1e-15	-5.3	-5.3	1.4e-07	0.92	0.01	0.99	FALSE
43	YFS	Blood	PRSS36	0.02	0.02	enet	8	0.02	1.1e-07	-5.3	-5.3	1.3e-07	0.90	0.01	0.98	FALSE
44	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	5.3	5.4	7.1e-08	-0.43	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	-5.3	-6.0	1.6e-09	0.92	0.01	0.90	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	-5.3	-6.0	2.0e-09	0.88	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	5.2	-6.0	1.4e-09	0.54	0.01	0.50	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	5.3	-5.3	1.4e-07	0.60	0.02	0.87	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	-4.3	-5.8	6.1e-09	0.79	0.04	0.72	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	5.3	5.4	7.0e-08	-0.43	0.02	0.83	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	-5.3	-5.9	3.0e-09	0.91	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	5.1	-5.2	1.6e-07	0.47	0.02	0.97	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	5.3	5.8	5.3e-09	-0.65	0.02	0.92	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYST1	0.07	0.01	enet	6	0.04	1.6e-03	5.3	-5.5	3.9e-08	0.66	0.02	0.84	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	5.3	-6.1	1.3e-09	0.82	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	5.3	5.6	1.9e-08	-0.66	0.02	0.78	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	MYST1	0.09	0.03	blup	33	0.03	1.4e-04	-5.3	-5.5	4.3e-08	0.91	0.01	0.97	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYST1	0.08	0.08	enet	8	0.08	2.8e-09	-5.3	-5.5	2.8e-08	0.98	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	-3.9	-5.2	1.7e-07	0.74	0.04	0.63	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	5.3	-5.7	9.2e-09	0.64	0.02	0.90	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	5.3	-6.1	9.6e-10	0.82	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MYST1	0.07	0.09	lasso	3	0.07	1.0e-03	-5.5	-6.1	8.7e-10	0.97	0.01	0.83	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	5.3	-5.9	3.6e-09	0.79	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS36	0.17	0.13	blup	27	0.14	1.0e-14	-5.5	-5.5	4.0e-08	0.87	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	5.3	-6.1	1.1e-09	0.71	0.01	0.58	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	-5.3	-5.9	2.9e-09	0.86	0.01	0.67	FALSE
67	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	5.3	-6.3	2.7e-10	0.74	0.02	0.94	TRUE
68	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	5.3	-6.1	9.4e-10	0.83	0.02	0.98	FALSE