Best TWAS P=4.63e-15 · Best GWAS P=1.39e-13 conditioned to 0.538
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CISD2 | 0.02 | 0.00 | blup | 322 | 0.00 | 2.7e-01 | 6.5 | -6.5 | 9.6e-11 | 0.63 | 0.15 | 0.37 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MANBA | 0.08 | 0.04 | bslmm | 390 | 0.03 | 9.6e-05 | 5.3 | -6.5 | 9.5e-11 | 0.53 | 0.76 | 0.19 | FALSE |
| 3 | GTEx | Muscle Skeletal | CISD2 | 0.03 | 0.02 | enet | 15 | 0.03 | 7.9e-04 | 5.3 | 6.0 | 1.6e-09 | -0.50 | 0.55 | 0.29 | FALSE |
| 4 | GTEx | Pancreas | MANBA | 0.14 | 0.14 | enet | 5 | 0.06 | 1.8e-03 | -6.7 | 6.7 | 2.7e-11 | -0.58 | 0.34 | 0.45 | FALSE |
| 5 | METSIM | Adipose | SLC9B1 | 0.02 | 0.03 | lasso | 8 | 0.02 | 1.2e-04 | -6.7 | -6.7 | 1.6e-11 | 0.58 | 0.26 | 0.63 | FALSE |
| 6 | YFS | Blood | MANBA | 0.09 | 0.10 | lasso | 3 | 0.10 | 5.2e-30 | -6.7 | -6.7 | 2.0e-11 | 0.58 | 0.47 | 0.53 | FALSE |
| 7 | YFS | Blood | NFKB1 | 0.04 | 0.03 | lasso | 6 | 0.03 | 5.4e-09 | -6.9 | -6.8 | 1.5e-11 | 0.84 | 0.12 | 0.88 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MANBA | 0.03 | 0.03 | blup | 71 | 0.04 | 2.0e-05 | -4.3 | -5.8 | 8.2e-09 | 0.53 | 0.62 | 0.21 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NFKB1 | 0.10 | 0.06 | blup | 90 | 0.07 | 2.2e-03 | -7.2 | 7.8 | 4.6e-15 | -0.91 | 0.03 | 0.89 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | NFKB1 | 0.06 | 0.09 | enet | 7 | 0.09 | 9.1e-09 | -6.9 | -7.1 | 1.4e-12 | 0.91 | 0.06 | 0.94 | FALSE |