Best TWAS P=3.53e-11 · Best GWAS P=6.42e-11 conditioned to 0.161
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FCHSD1 | 0.06 | 0.03 | enet | 6 | 0.04 | 1.8e-05 | -4.9 | 5.4 | 5.2e-08 | 0.04 | 0.36 | 0.55 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | AC008781.7 | 0.17 | 0.00 | enet | 45 | 0.04 | 4.7e-04 | -2.3 | -5.8 | 6.1e-09 | 0.01 | 0.08 | 0.16 | TRUE |
| 3 | GTEx | Muscle Skeletal | NDFIP1 | 0.20 | 0.10 | lasso | 9 | 0.12 | 3.8e-12 | -6.5 | 6.6 | 3.5e-11 | -0.93 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | GNPDA1 | 0.11 | 0.00 | enet | 23 | 0.00 | 1.5e-01 | 5.1 | 5.2 | 1.7e-07 | -0.69 | 0.02 | 0.92 | FALSE |
| 5 | METSIM | Adipose | NDFIP1 | 0.23 | 0.15 | lasso | 8 | 0.16 | 7.1e-23 | -5.0 | -5.5 | 4.9e-08 | 0.73 | 0.97 | 0.03 | FALSE |
| 6 | NTR | Blood | NDFIP1 | 0.03 | 0.00 | blup | 610 | 0.01 | 2.9e-03 | -5.3 | -6.2 | 6.3e-10 | 0.63 | 0.03 | 0.96 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PCDHGA6 | 0.08 | 0.03 | enet | 19 | 0.05 | 9.1e-07 | -4.6 | 5.3 | 1.1e-07 | 0.05 | 0.84 | 0.15 | FALSE |