Best TWAS P=1.93e-10 · Best GWAS P=9.19e-14 conditioned to 2.07e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | KIF3A | 0.08 | 0.07 | lasso | 3 | 0.07 | 1.2e-06 | 5.8 | -6.0 | 2.0e-09 | -0.30 | 0.95 | 0.01 | FALSE |
2 | GTEx | Artery Aorta | KIF3A | 0.13 | 0.07 | enet | 7 | 0.07 | 6.3e-05 | 5.6 | -6.2 | 7.3e-10 | -0.36 | 0.92 | 0.02 | FALSE |
3 | GTEx | Artery Tibial | KIF3A | 0.11 | 0.08 | lasso | 5 | 0.09 | 3.2e-07 | 5.6 | -6.4 | 1.9e-10 | -0.33 | 0.98 | 0.00 | TRUE |
4 | GTEx | Cells EBV-transformed lymphocytes | SLC22A5 | 0.37 | 0.05 | lasso | 13 | 0.10 | 2.8e-04 | -4.9 | 5.1 | 3.0e-07 | 0.29 | 0.49 | 0.03 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | KIF3A | 0.15 | 0.16 | enet | 7 | 0.15 | 2.6e-11 | 5.6 | -6.0 | 2.0e-09 | -0.35 | 1.00 | 0.00 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | SEPT8 | 0.15 | 0.12 | lasso | 4 | 0.11 | 6.9e-09 | 5.6 | -5.9 | 3.8e-09 | -0.29 | 0.99 | 0.00 | FALSE |
7 | GTEx | Esophagus Muscularis | KIF3A | 0.31 | 0.17 | lasso | 5 | 0.20 | 2.2e-12 | 5.5 | -5.9 | 3.8e-09 | -0.34 | 1.00 | 0.00 | FALSE |
8 | GTEx | Nerve Tibial | KIF3A | 0.23 | 0.17 | lasso | 5 | 0.15 | 5.3e-11 | 5.8 | -6.0 | 2.4e-09 | -0.38 | 1.00 | 0.00 | FALSE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | SEPT8 | 0.15 | 0.17 | lasso | 2 | 0.17 | 1.4e-09 | 5.8 | 6.1 | 8.1e-10 | 0.37 | 0.98 | 0.00 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | KIF3A | 0.11 | 0.04 | lasso | 4 | 0.04 | 6.2e-04 | 5.8 | -6.2 | 5.3e-10 | -0.32 | 0.63 | 0.03 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | SEPT8 | 0.46 | 0.35 | lasso | 6 | 0.33 | 3.2e-28 | 5.6 | 5.8 | 4.8e-09 | 0.25 | 1.00 | 0.00 | FALSE |
12 | GTEx | Thyroid | PDLIM4 | 0.05 | 0.02 | enet | 5 | 0.01 | 3.1e-02 | -3.5 | 5.3 | 1.3e-07 | 0.47 | 0.16 | 0.65 | FALSE |
13 | METSIM | Adipose | KIF3A | 0.08 | 0.08 | lasso | 15 | 0.07 | 4.0e-11 | 4.8 | -5.4 | 5.3e-08 | -0.31 | 1.00 | 0.00 | FALSE |
14 | NTR | Blood | IRF1 | 0.03 | 0.02 | blup | 424 | 0.01 | 5.7e-05 | 4.6 | -5.6 | 1.9e-08 | -0.12 | 1.00 | 0.00 | TRUE |