TWAS hub - FCHSD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0250	1.3e-02	0.027	0.026	0.038	0.030	0.034	2.8e-04	3e-04	1.8e-05	1.2e-04	5.0e-05
2	GTEx	Artery Tibial	0.1367	0.0501	4.4e-03	0.091	NA	0.020	NA	0.077	1.4e-07	NA	9.6e-03	NA	1.2e-06
3	GTEx	Cells Transformed fibroblasts	0.1050	0.0400	3.9e-03	-0.004	NA	-0.004	NA	-0.003	9.7e-01	NA	8.6e-01	NA	5.9e-01
4	GTEx	Nerve Tibial	0.2855	0.0615	5.5e-07	0.098	NA	0.191	NA	0.182	2.1e-07	NA	1.6e-13	NA	6.4e-13
5	METSIM	Adipose	0.0947	0.0284	8.6e-05	0.037	0.037	0.024	0.052	0.040	2.5e-06	3e-06	1.5e-04	3.0e-08	9.9e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pulse wave peak to peak time	5.1	6.0	16.0	1.9	2.1	4.0	1.7	1.8
Hayfever, allergic rhinitis or eczema	4.9	10.7	23.5	4.8	2.4	3.1	3.2	2.0
Major Depression (MDD)	4.5	5.5	9.1	3.0	2.9	1.6	2.1	1.7
Allergy	4.4	10.2	26.0	-5.1	-2.2	-2.9	-3.0	-1.7
Allergy or Eczema	4.3	11.2	29.6	5.4	2.2	3.1	2.9	2.0
Medication: Ibuprofen	4.0	4.7	10.7	3.3	0.8	2.4	1.4	2.2
Pulse wave Arterial Stiffness index	3.9	4.5	12.4	-1.4	-1.8	-3.5	-1.5	-1.6
Tense / ‘highly strung’	3.5	5.8	8.9	2.6	2.2	2.2	3.0	1.8
Heart disease (siblings)	3.4	4.2	8.4	-0.4	-2.9	-2.6	-2.1	-1.1
Medication: Cholesterol lowering	3.2	4.9	7.1	-2.7	-2.5	-2.4	-2.3	0.3
Medication: Paracetamol	3.1	4.8	6.5	2.6	2.1	1.3	2.5	2.2
Frequency of depressed mood in last 2 weeks	3.0	4.2	7.5	2.7	2.1	1.5	2.3	1.0
Time employed in main current job	3.0	3.4	5.8	1.6	1.3	1.9	1.9	2.4
Mouth/teeth dental problems: Loose teeth	2.9	3.4	6.2	-0.9	-2.0	-1.9	-2.5	-1.6
Coronary Artery Disease (CAD)	2.6	3.1	7.5	-2.0	2.7	0.7	1.6	1.0
Medication: Metformin	2.6	3.7	10.4	-3.2	-1.9	-1.3	-1.6	-0.0
Forced vital capacity (FVC)	2.6	10.0	21.1	1.8	3.4	4.6	2.9	2.3
Commuting to job workplace: Walk	2.6	2.8	5.6	0.1	-1.8	-0.6	-2.4	-2.1
Medication: Simvastatin	2.5	3.7	10.7	-3.3	-1.4	-1.7	-1.6	0.4
Medication for cholesterol, blood pressure or diabetes	2.5	4.2	6.2	1.9	2.4	2.5	2.3	-0.0
Migraine (self-reported)	2.5	3.1	7.0	-0.1	-0.9	-2.3	-1.5	-2.7
Respiratory disease	2.4	5.3	14.9	3.9	1.6	1.7	2.4	0.3
Pack years adult smoking proportion	2.4	3.7	4.8	-0.9	-2.2	-2.1	-2.1	-1.9
Had major operations	2.4	2.8	6.3	1.5	1.0	2.5	1.2	1.8
Osteoporosis (self-reported)	2.4	2.9	5.5	-1.2	-2.1	-2.3	-1.7	-0.4
Irritability	2.4	4.0	8.3	2.9	1.9	1.5	2.3	0.5
Falls in the last year	2.3	3.1	7.3	0.1	-0.7	-2.7	-1.6	-2.2
Length of working week for main job	2.3	2.6	9.7	-0.1	-1.2	-0.7	-1.1	-3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	7.6	0.5	1.7	0.1	2.8	1.8
Average weekly red wine intake	2.3	3.4	7.8	0.8	1.2	2.8	1.3	2.4
Mood swings	2.3	4.1	6.9	2.0	2.6	1.6	2.1	1.6
Ever smoked	2.3	4.0	8.4	0.0	2.8	1.7	2.9	0.9
Worry (Nagel 2018)	2.2	4.7	9.2	3.0	2.0	2.3	2.1	0.9
Supplements: Zinc	2.2	2.3	3.7	-1.1	1.9	1.9	0.8	1.6
Townsend deprivation index at recruitment	2.2	3.0	5.6	-2.1	-1.5	-2.4	-1.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.7	8.4	2.9	-0.0	1.6	0.7	1.6
Birth weight of first child	2.2	3.9	9.2	2.9	-0.4	3.0	0.4	1.2
Medication: Paracetamol	2.2	3.6	6.7	2.6	1.8	0.9	2.1	1.5
Ever had bowel cancer screening	2.2	2.6	4.8	2.2	0.7	1.8	2.0	0.6
Age when periods started (menarche)	2.1	5.1	8.3	-0.5	-2.1	-2.2	-2.9	-2.7
Pulse wave reflection index	2.1	2.6	4.4	-1.2	-2.1	-1.9	-1.5	-1.1
Exposure to tobacco smoke outside home	2.1	2.8	6.2	-2.5	0.6	-2.4	-0.2	-1.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.2	1.3	2.3	1.2	1.4	1.1
Asthma (self-reported)	2.0	4.1	8.6	2.9	1.7	2.0	2.1	0.6
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	12.2	0.6	3.3	3.5	2.4	1.5
Pack years of smoking	1.9	2.8	4.3	-0.8	-2.1	-1.8	-1.9	-1.5
Forced vital capacity (FVC), Best measure	1.8	6.5	15.0	1.8	2.8	3.9	1.8	1.8
Eye problems/disorders: None of the above	1.8	2.1	5.3	1.7	2.3	-0.8	1.2	0.6
Medication: Omeprazole	1.8	2.2	3.5	0.1	-1.8	-1.6	-1.9	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	7.6	2.8	1.9	1.9	1.7	-1.1
Eye problems/disorders: Cataract	1.8	2.1	4.1	-2.0	-1.9	-0.7	-1.4	-0.6
Risk taking	1.8	2.6	4.8	1.3	2.2	1.1	2.0	1.2
Supplements: Calcium	1.8	2.0	4.0	0.3	-1.7	-2.0	-1.6	-0.7
Past tobacco smoking	1.7	3.1	8.0	-0.0	-2.1	-1.0	-2.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	6.2	-1.4	-1.1	-2.5	-0.6	-0.5
Smoking status: Previous	1.7	2.6	5.7	-0.7	1.6	0.8	2.4	1.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.5	1.1	2.1	1.1	1.9	0.2
Worrier / anxious feelings	1.6	3.0	5.3	2.2	1.1	2.3	1.3	1.2
Asthma	1.6	3.1	6.8	2.6	1.5	1.6	1.9	0.4
Alcohol drinker status: Never	1.6	1.9	3.9	0.8	-1.3	-2.0	-1.6	-0.8
Age at First Birth	1.5	2.2	3.9	0.2	1.2	1.7	1.7	2.0
Rheumatoid Arthritis	1.5	2.0	3.3	0.4	-1.7	-1.8	-1.5	-1.2
Impedance of whole body	1.5	7.6	28.3	5.3	-1.0	0.7	-0.6	-2.8
Schizophrenia (2018)	1.4	3.0	7.9	0.9	2.2	0.3	2.8	1.0
Supplements: Glucosamine	1.4	1.8	3.2	0.4	1.1	1.8	1.1	1.8
Nervous feelings	1.4	2.6	6.1	2.5	1.2	1.5	1.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	8.6	1.0	2.9	2.9	1.7	1.0
Impedance of arm (left)	1.4	6.4	20.5	4.5	-0.8	1.2	-0.6	-3.0
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.7	0.1	0.5	1.9	0.7	1.9
Prostate Cancer	1.3	1.8	4.1	-2.0	-1.7	-0.5	-1.0	-0.8
Ever had hysterectomy (womb removed)	1.3	1.4	4.8	2.2	-1.2	-0.5	-0.7	-0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.6	-1.6	-1.2	-0.4	-1.2	-1.1
Hearing difficulty/problems with background noise	1.3	2.0	6.9	2.6	0.5	1.0	1.3	0.5
Impedance of arm (right)	1.3	6.0	21.4	4.6	-0.3	1.2	-0.3	-2.6
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.8	1.3	1.1	-0.4	1.9	-1.2
Angina (self-reported)	1.3	1.7	3.6	-1.4	-1.9	-0.9	-0.9	1.2
Number of full sisters	1.3	1.5	7.4	-2.7	-0.3	-0.4	0.3	-0.2
Medication: Gliclazide	1.3	1.5	5.2	-2.3	-1.1	-0.1	-0.9	-0.3
Number of operations (self-reported)	1.3	1.9	6.8	2.6	-1.0	1.3	-0.2	0.2
Average weekly beer plus cider intake	1.3	1.8	3.5	-1.7	0.1	-1.9	-0.7	-1.5
Ever depressed for a whole week	1.3	1.6	4.3	-0.3	2.1	-0.1	1.6	1.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.9	0.2	-1.7	-1.6	-1.4	-0.5
Ulcerative Colitis	1.2	1.7	5.8	-1.1	2.4	-0.2	1.2	-0.3
Neuroticism	1.2	2.8	6.6	2.6	1.2	1.7	1.7	0.6
Severe depression (siblings)	1.2	1.4	4.7	2.2	1.0	0.3	0.9	-0.3
Impedance of leg (right)	1.2	5.8	20.5	4.5	-1.3	-0.1	-0.7	-2.5
Chronic bronchitis/emphysema (father)	1.2	1.5	4.0	-0.7	-0.9	-2.0	-1.2	-0.8
Body mass index (BMI)	1.2	5.1	16.3	-4.0	-0.7	-2.9	-0.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.8	2.0	1.5	0.9	1.5	0.3
Had other major operations	1.2	1.5	4.1	1.2	-2.0	0.5	-1.3	-0.2
Pulse rate	1.2	2.0	6.7	0.9	2.6	0.1	1.4	0.6
Happiness	1.2	1.4	3.2	-0.2	1.4	0.4	1.3	1.8
Hair/balding pattern: Pattern 4	1.2	2.9	6.0	-0.9	2.5	0.9	2.0	1.6
Medication: Blood pressure	1.2	2.0	2.9	-1.3	-1.7	-1.7	-1.4	0.8
Hearing aid user	1.2	1.3	3.0	0.1	-0.1	1.7	1.1	1.6
Mother’s age at death	1.2	1.4	3.3	-0.4	1.1	1.4	1.8	0.7
Age started oral contraceptive pill	1.2	1.5	4.1	0.6	-0.7	1.5	0.3	2.0
Depression (Nagel 2018)	1.1	1.7	7.1	2.7	0.9	-0.3	0.5	-0.7
Neuroticism (Nagel 2018)	1.1	2.7	5.9	2.4	1.4	1.6	1.6	0.5
Systolic blood pressure, automated reading	1.1	3.2	6.9	-2.6	-1.1	-2.5	-1.1	-0.3
Angina	1.1	1.5	3.1	-1.1	-1.8	-0.8	-0.8	1.4
Average weekly fortified wine intake	1.1	1.3	3.3	1.8	0.8	1.5	0.5	0.1
Medication: Atenolol	1.1	1.3	2.6	-1.6	-1.3	-0.4	-0.8	1.1
High blood pressure (mother)	1.1	1.5	2.2	1.5	1.2	0.7	1.3	1.2
Impedance of leg (left)	1.1	5.5	21.5	4.6	-1.5	0.1	-0.4	-1.9
Alcohol intake versus 10 years previously	1.1	1.7	4.5	-2.1	0.1	-2.0	0.1	0.4
Number of live births	1.1	1.6	2.8	-1.7	-1.7	-0.5	-1.3	-0.4
Qualifications: A levels/AS levels or equivalent	1.1	2.3	4.8	1.2	2.2	2.0	1.0	-0.6
Mouth/teeth dental problems: Dentures	1.1	1.8	7.8	-2.8	-0.1	-0.6	-0.8	-0.2
Standing height	1.1	11.1	25.4	5.0	1.3	5.0	1.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.4	1.4	1.5	0.8	1.5	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	0.4	2.0	1.3	1.5	0.6
Blood clot in the leg (DVT)	1.1	1.4	3.5	0.7	-1.6	0.7	-1.9	-0.1
Headache pain in last month	1.1	1.8	4.1	1.6	1.1	-0.9	0.6	-2.0
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.1	-0.3	-0.9	-1.3	-1.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.6	2.1	0.5	0.5	1.2	1.6
Back pain experienced in last month	1.1	1.6	2.4	1.1	1.3	1.6	1.5	0.7
Wears glasses or contact lenses	1.1	1.2	2.6	-0.9	-1.4	0.6	-1.6	0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.1	2.0	-0.5	-0.3	0.1	-1.3
Stomach or abdominal pain in last month	1.0	1.3	2.6	1.6	0.3	-1.6	0.4	-1.0
Financial difficulties in last 2 years	1.0	1.4	2.4	-1.4	-1.2	-1.6	-0.9	-0.5
Pain all over the body in last month	1.0	1.0	4.1	-0.4	2.0	-0.5	0.8	-0.2
Illnesses of siblings	1.0	1.4	5.3	0.1	0.9	2.3	0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.1	-1.3	1.8	0.4	1.0	-0.2
Medication: Seretide 50 evohaler	1.0	1.2	2.2	0.9	0.7	1.1	1.0	1.5
Heart disease (mother)	1.0	1.2	2.0	1.4	1.4	-0.0	1.3	0.4
Comparative height size at age 10	1.0	5.5	11.6	2.6	2.2	3.4	1.8	1.0
Illnesses of father: Heart disease	1.0	1.3	3.8	-0.3	-1.9	-0.4	-1.6	-0.3
Diabetes diagnosed by doctor	1.0	1.7	4.1	-2.0	-1.5	-1.2	-0.8	0.3
Medication: Aspirin	1.0	1.3	2.5	-0.7	-1.2	-0.2	-1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	7.6	-2.8	1.7	0.5	0.5	0.1
High cholesterol (Self-reported)	1.0	1.9	4.9	-2.2	-0.6	-1.5	-0.8	1.1
Unable to work because of sickness or disability	1.0	1.2	3.6	1.5	-0.0	-1.9	0.5	-0.3
Myopia	1.0	1.4	3.1	-1.8	-1.1	0.6	-1.5	-0.0
Schizophrenia vs Biploar Disorder	0.9	1.2	3.8	0.3	1.1	0.8	1.9	0.2
Alzheimer’s Disease (in father)	0.9	1.0	4.4	-0.7	-0.1	2.1	0.1	0.1
Blood White Count	0.9	6.9	22.6	-3.3	0.1	-4.8	-0.4	-0.9
Sensitivity / hurt feelings	0.9	1.6	3.4	0.7	0.8	1.4	1.2	1.9
Hearing difficulty/problems: Yes	0.9	1.3	2.5	1.2	1.5	0.4	1.6	-0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.6	1.3	-1.6	1.1	-0.5	0.4
Maternal smoking around birth	0.9	1.2	3.2	-0.4	-0.6	-1.8	-0.4	-1.5
Had menopause	0.9	1.1	2.7	-0.2	-1.3	0.6	-0.7	1.6
Father’s age at death	0.9	1.3	2.7	1.4	1.0	1.7	0.8	-0.2
Number of children fathered	0.9	1.1	1.7	0.1	1.1	1.2	1.0	1.3
Qualifications: College or University degree	0.9	2.9	10.2	2.0	-0.2	3.2	0.2	0.5
Family relationship satisfaction	0.9	1.1	2.0	-1.0	1.4	-0.7	1.3	0.5
Medication: Aspirin	0.9	1.2	2.2	-0.2	-1.5	-0.4	-1.3	1.5
Arm fat percentage (left)	0.9	3.5	8.8	-3.0	-1.1	-2.5	-0.4	-1.0
Long-standing illness, disability or infirmity	0.9	1.4	3.5	1.9	-1.7	0.2	-0.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.5	-0.9	-0.0	-1.0	-0.7	-1.6
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.8	1.2	0.6	1.7	0.8	0.6
Basal cell carcinoma (self-reported)	0.9	1.1	3.5	0.8	-0.1	0.9	0.4	1.9
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.4	0.3	-1.5	0.5	-1.8	-0.2
Schizophrenia (2014)	0.8	1.8	3.2	1.7	1.6	0.3	1.8	-0.4
BMI	0.8	4.4	13.8	-3.7	0.4	-2.9	0.2	-0.1
Average weekly spirits intake	0.8	1.0	2.2	0.7	-1.5	-0.5	-0.7	-1.2
Diabetes (self-reported)	0.8	1.2	3.1	-1.8	-1.3	-0.6	-0.7	0.5
Neuroticism score	0.8	1.7	2.8	1.7	1.4	1.1	1.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.2	2.0	-0.2	1.2	0.4	0.8
Depression (self-reported)	0.8	1.0	2.8	0.1	1.1	0.6	0.9	1.7
Prospective memory result	0.8	1.0	3.8	2.0	0.4	0.2	-0.2	-0.9
Age at first live birth	0.8	1.4	3.8	0.9	1.3	2.0	0.2	0.6
Emphysema/chronic bronchitis	0.8	0.9	1.6	1.2	-0.5	-0.3	1.0	1.3
Medication: Lisinopril	0.8	1.1	2.9	-0.6	-1.7	-0.2	-1.2	0.8
Crohns Disease (2017)	0.7	1.6	3.6	-1.8	-0.0	-1.9	0.1	-1.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.3	-1.8	1.3	-1.4	0.8	-0.9
Height	0.7	14.0	31.8	5.6	0.9	5.6	1.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.8	1.3	0.3	-1.2	-0.1	-1.3
Sitting height	0.7	4.9	12.9	3.1	0.9	3.6	0.6	0.9
Arm fat percentage (right)	0.7	2.8	6.9	-2.6	-0.9	-2.3	-0.2	-0.7
Exposure to tobacco smoke at home	0.7	0.8	2.9	-1.7	0.5	-1.0	-0.0	-0.0
Breastfed as a baby	0.7	0.8	2.9	0.0	1.0	0.5	1.7	-0.0
Gout (self-reported)	0.7	1.0	1.9	-1.4	-0.4	0.9	-0.6	1.3
Number of full brothers	0.7	0.8	1.7	-1.0	-1.3	-0.7	-0.9	-0.1
Loneliness, isolation	0.7	0.9	2.3	0.8	1.5	0.1	1.2	0.6
Qualifications: nursing, teaching	0.7	1.1	3.6	0.2	-0.1	1.9	-0.6	-1.2
Breast cancer (self-reported)	0.7	0.8	3.0	-0.3	-1.7	-0.7	-0.6	-0.3
Ever taken oral contraceptive pill	0.7	0.8	2.3	0.6	1.5	-0.5	1.0	-0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.8	1.2	-0.2	-1.7	-0.1	0.3
Medication: Atorvastatin	0.7	0.8	2.3	0.0	0.3	0.1	1.3	1.5
Primary Biliary Cirrhosis	0.6	0.9	3.1	-0.5	1.8	0.2	1.1	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.5	1.6	-0.9	0.2	-0.1	0.7
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.3	-0.9	-1.2	-0.3	-1.0
Current tobacco smoking	0.6	1.0	2.1	1.1	-0.9	-0.5	-1.0	-1.5
Taking other prescription medications	0.6	0.9	2.7	1.6	-0.4	0.6	0.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.3	1.5	0.6	-0.7	0.6	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.5	0.8	0.3	-1.2	-0.7	-0.9
Mouth/teeth dental problems	0.6	0.9	2.8	1.0	0.4	1.7	0.6	-0.0
Heart attack	0.6	0.8	3.7	-0.5	0.1	-1.9	0.2	-0.2
Glaucoma (self-reported)	0.6	0.7	1.6	0.9	0.0	1.3	1.0	-0.1
High blood pressure (siblings)	0.6	0.8	3.1	-1.0	0.2	-1.8	-0.1	0.0
Leg fat percentage (right)	0.6	2.3	6.9	-1.7	-1.3	-2.6	-0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	1.5	0.5	0.2	0.7	1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	3.5	-1.9	0.1	0.2	-0.4	-1.2
Medication: Allopurinol	0.6	0.8	1.7	-0.8	0.8	0.8	0.4	1.3
Knee pain experienced in last month	0.6	1.0	3.7	1.9	-0.5	-0.9	-0.3	0.3
Friendships satisfaction	0.6	0.7	1.9	-0.2	1.4	0.2	0.7	1.0
Arm fat mass (left)	0.6	2.5	8.2	-2.9	-0.8	-1.8	-0.3	-0.6
Number of self-reported non-cancer illnesses	0.6	1.1	3.8	0.7	-0.2	1.0	0.4	1.9
Financial situation satisfaction	0.6	0.8	2.2	-1.5	-0.5	-1.1	-0.5	0.3
Medication: Bendroflumethiazide	0.6	1.0	4.0	0.5	0.4	0.4	0.5	2.0
Leg fat percentage (left)	0.6	2.3	6.0	-1.9	-1.4	-2.4	-0.1	0.0
Cholesterol lowering medication	0.6	0.9	3.5	-1.9	-0.0	-0.4	0.1	0.9
Pain experienced in last month	0.6	1.0	2.4	-0.4	0.1	1.6	0.5	1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.3	-0.6	0.3	-1.8	0.3	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.7	1.1	1.4	-0.1	1.7	0.2
Depressed Affect (Nagel 2018)	0.5	1.1	3.0	1.7	1.0	0.8	0.8	0.6
Ulcerative Colitis (UC)	0.5	0.9	2.7	-0.9	1.6	-0.3	0.8	-0.6
Bipolar Disorder (2011)	0.5	0.5	1.1	0.7	1.1	-0.7	0.4	-0.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-0.3	0.9	-0.4	1.1	1.1
Mean Putamen Volume	0.5	0.5	1.1	-0.7	1.0	0.4	0.9	0.1
Triglycerides	0.5	0.9	3.4	1.9	-0.6	-0.7	0.2	0.2
Blood Platelet Count	0.5	5.8	13.2	-3.6	-1.2	-3.1	-1.8	0.9
Number of treatments/medications taken	0.5	0.9	2.9	1.0	-0.7	-0.4	-0.1	1.7
Trunk fat percentage	0.5	1.8	4.5	-0.4	-1.4	-2.1	-0.3	-1.6
Relative age voice broke	0.5	0.7	2.6	-1.6	-1.0	-0.2	0.1	0.1
Waist circumference	0.5	1.9	6.1	-2.5	-1.0	-1.4	0.1	-0.3
Medication: Ramipril	0.5	0.7	1.6	-1.3	0.3	-0.2	-0.2	1.2
Trunk fat-free mass	0.5	2.8	4.7	-1.3	1.3	2.2	1.3	2.1
Hip circumference	0.5	2.0	5.3	-2.3	-1.1	-1.4	-0.9	-1.0
Illnesses of mother	0.5	0.6	2.5	-0.5	-0.0	0.1	-0.3	-1.6
Arm fat mass (right)	0.5	2.0	6.3	-2.5	-0.7	-1.7	-0.2	-0.5
Trunk predicted mass	0.5	2.6	4.5	-1.3	1.1	2.1	1.2	2.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.4	1.6	0.2	0.2	0.5	-0.5
Body fat percentage	0.5	2.1	6.1	-1.1	-1.4	-2.5	-0.3	-1.1
Neck or shoulder pain in last month	0.5	0.6	1.1	1.0	-0.4	1.1	0.5	0.8
Leg fat mass (right)	0.5	1.8	5.1	-2.2	-0.5	-1.9	0.2	-0.2
Alcohol intake frequency.	0.5	1.1	4.7	0.6	0.0	-2.2	-0.1	-0.5
Overall health rating	0.5	1.2	5.4	-0.0	-0.7	-2.3	0.1	-0.0
Chest pain or discomfort	0.5	0.8	2.4	1.1	-0.0	0.4	0.4	1.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	-1.1	-0.6	0.9	0.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	0.6	-0.5	1.0	0.4	1.0
Commuting to job workplace: Public transport	0.5	0.6	1.3	-0.7	-0.2	-0.7	-1.1	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	1.0	-0.4	1.0	0.2	0.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.2	1.4	1.3	0.6	1.5	-0.5
Leg fat mass (left)	0.5	1.9	5.3	-2.3	-0.7	-2.0	0.2	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.4	0.3	-0.9	0.4	-1.8	-1.5
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	-1.5	-0.1	0.7	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	0.3	-1.1	1.2	-1.1	-1.0
Ovarian Cancer	0.4	0.6	0.9	-0.9	0.7	0.5	0.7	0.9
Crohns Disease (2012)	0.4	0.7	1.4	-0.8	0.5	-1.2	0.4	-1.0
HDL Cholesterol	0.4	0.7	1.5	-0.8	1.1	1.2	0.3	0.2
Heel T-Score	0.4	3.0	7.8	0.2	2.5	0.1	2.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.7	-0.3	1.3	-1.3	0.6	-0.9
Fluid intelligence score	0.4	0.8	3.4	-0.1	-0.2	0.3	-0.8	-1.9
Worry too long after embarrassment	0.4	0.6	2.6	0.3	-0.1	-0.1	0.6	-1.6
Wheeze or whistling in the chest in last year	0.4	0.7	2.9	0.6	-0.3	-1.7	0.1	-0.6
Age at last live birth	0.4	0.6	1.6	0.7	-0.8	0.5	-1.3	-0.4
Leg pain on walking	0.4	0.4	1.3	1.1	0.3	0.3	0.1	0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.0	0.6	-1.2	0.8	-0.5
Whole body fat-free mass	0.4	2.1	2.8	-1.6	1.2	1.5	1.1	1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.8	0.1	0.8	0.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	0.4	0.8	0.1	0.6	1.0
Smoking status: Current	0.4	0.7	1.5	1.2	-0.3	-0.3	-0.6	-1.2
Whole body water mass	0.4	2.1	3.2	-1.8	1.1	1.4	1.1	1.6
Guilty feelings	0.4	0.5	1.2	1.1	0.8	-0.2	0.8	0.4
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.8	-0.1	0.9	0.4	-0.8
Medication: Blood pressure	0.4	0.7	2.6	-0.8	-0.0	0.7	-0.2	1.6
Illnesses of father: High blood pressure	0.4	0.5	1.2	0.2	1.1	0.6	0.8	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.3	-0.4	-0.5	0.2	-1.1	-1.0
Bipolar Disorder (2018)	0.3	0.5	0.9	0.6	-0.6	-0.6	-0.9	-0.9
Fasting Glucose	0.3	0.4	1.5	0.2	0.4	0.1	1.2	0.4
HbA1C	0.3	0.4	1.1	-1.0	-0.7	-0.0	-0.4	0.4
Blood Red Count	0.3	2.6	8.2	0.8	-1.4	-2.9	-1.1	-0.9
Waist Hip Ratio (WHR)	0.3	1.1	2.6	1.2	-0.3	1.2	1.6	0.1
Systolic Blood Pressure	0.3	1.7	5.6	-1.6	0.2	-2.4	-0.3	-0.1
Cardiovascular Disease	0.3	1.0	4.4	-0.5	0.5	-0.2	0.1	2.1
Lung FVC	0.3	1.6	6.2	-2.5	0.7	0.7	-0.5	0.6
Chronotype (morning person)	0.3	0.8	2.2	-0.2	1.5	1.0	0.6	-0.4
Diabetes (father)	0.3	0.3	0.8	-0.1	-0.9	-0.6	-0.5	-0.6
Leg fat-free mass (left)	0.3	1.4	3.5	-1.9	1.2	0.7	0.9	0.8
Hand grip strength (right)	0.3	0.8	2.8	-0.8	0.6	-1.7	-0.6	-0.1
High blood pressure	0.3	0.9	2.5	-1.6	-0.7	-0.2	-0.8	0.8
Leg predicted mass (left)	0.3	1.5	3.7	-1.9	1.2	0.8	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.6	0.2	1.1	-1.3	0.7	-0.8
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	1.1	-0.2	-0.7	-0.1	-0.9
Lung cancer (father)	0.3	0.3	0.7	-0.2	-0.9	-0.4	0.1	0.8
Peak expiratory flow (PEF)	0.3	0.7	2.2	-0.5	1.5	0.4	0.8	0.2
Loud music exposure frequency	0.3	0.4	1.2	0.0	-0.3	-0.7	-0.2	-1.1
Medication: Amlodipine	0.3	0.4	1.3	-0.4	-0.6	-0.0	-0.1	1.1
Arm fat-free mass (right)	0.3	1.5	4.1	-2.0	0.4	0.7	0.7	1.4
Comparative body size at age 10	0.3	0.9	3.7	-1.9	0.3	-0.7	0.1	0.3
Whole body fat mass	0.3	1.3	3.0	-1.6	-0.8	-1.7	-0.0	-0.6
Arm predicted mass (right)	0.3	1.6	4.0	-2.0	0.5	0.7	0.9	1.5
Suffer from ‘nerves’	0.3	0.5	1.0	1.0	0.9	0.7	0.2	-0.2
Hypertension (Self-reported)	0.3	0.9	1.8	-1.2	-0.9	-0.1	-0.8	1.4
Leg fat-free mass (right)	0.3	1.7	3.2	-1.8	1.2	1.0	1.1	1.2
Leg predicted mass (right)	0.3	1.7	3.6	-1.9	1.1	1.0	1.1	1.2
Miserableness	0.3	0.5	1.5	1.2	-0.8	0.2	-0.3	-0.2
Basal metabolic rate	0.3	1.4	2.8	-1.7	0.8	1.0	0.9	1.3
Arm fat-free mass (left)	0.3	1.5	3.0	-1.7	0.4	1.0	0.7	1.7
Diastolic blood pressure, automated reading	0.3	0.8	1.5	-1.0	-0.1	-1.2	-0.7	-1.1
Arm predicted mass (left)	0.3	1.4	3.0	-1.4	0.4	1.0	0.8	1.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.1	-0.7	0.4	-0.5	0.5
Lupus	0.2	0.3	0.8	-0.1	0.7	0.2	0.5	0.9
Neuroticism (2016)	0.2	0.3	0.8	0.9	0.3	-0.6	0.0	-0.2
Blood Eosinophil Count	0.2	1.6	4.7	0.1	0.5	-2.2	1.4	-1.0
Hypothyroidism (self reported)	0.2	0.5	1.9	1.4	-0.3	0.3	0.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.8	-0.0	-0.3	0.3	1.0
Hand grip strength (left)	0.2	0.4	1.1	-0.4	-0.1	-0.9	-1.0	0.4
Fed-up feelings	0.2	0.4	0.9	0.9	1.0	0.2	0.4	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	-0.3	-0.2	-0.5	-0.7	-0.7
Trunk fat mass	0.2	0.7	1.8	-0.7	-0.8	-1.4	0.1	-0.8
Number of incorrect matches in round	0.2	0.3	0.7	-0.4	-0.6	0.0	-0.5	0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.2	-0.8	-0.0	-0.3	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	1.0	0.4	0.4	-0.4	0.1
Qualifications: None of the above	0.2	0.4	1.3	-0.4	-0.6	0.1	0.7	1.1
Medication: Lansoprazole	0.2	0.3	0.8	0.9	0.2	0.6	0.0	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	1.0	-0.4	0.8	0.3	-0.4
Birth weight	0.2	0.4	1.0	0.3	-0.7	1.0	-0.0	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	0.4	0.1	-0.0	0.3	1.0
Health satisfaction	0.2	0.3	1.2	0.1	0.2	-1.1	-0.1	0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	0.1	0.1	-0.6	0.4	0.7
Mean time to correctly identify matches	0.2	0.4	1.0	-0.1	-1.0	0.0	-0.0	0.9
Pulse rate, automated reading	0.2	0.8	1.2	1.1	1.1	1.0	0.7	0.2
Supplements: Vitamin C	0.2	0.2	0.9	0.9	0.4	0.2	-0.0	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.0	1.0	0.3	0.1	-0.1	-0.5
Medication for cholesterol	0.2	0.3	0.5	0.7	-0.5	-0.2	-0.2	-0.7
Mineral and other dietary supplements	0.2	0.3	0.7	-0.3	0.6	-0.9	0.1	-0.4
Osteoarthritis (self-reported)	0.2	0.3	1.1	0.1	1.1	0.5	0.4	-0.1
Reaction Time	0.1	0.1	0.3	-0.5	-0.6	-0.2	-0.1	0.0
Breast Cancer	0.1	0.2	0.7	-0.5	0.1	-0.1	-0.1	0.8
LDL Cholesterol	0.1	0.2	0.6	-0.6	0.8	0.3	0.2	-0.2
Smoking Status	0.1	0.3	0.8	0.4	0.5	0.0	0.9	0.3
Lung FEV1/FVC ratio	0.1	0.7	2.0	-1.4	0.9	0.7	0.3	-0.5
Tanning	0.1	1.6	5.4	-0.8	0.3	1.4	0.1	2.3
Relative age of first facial hair	0.1	0.2	0.7	-0.8	-0.3	0.4	0.4	-0.2
Vitamin and mineral supplements	0.1	0.1	0.4	0.2	-0.6	0.5	-0.3	0.2
Diabetes (mother)	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.3	0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.4	0.5	0.1	0.1	-0.5
Multivitamins +/- minerals	0.1	0.1	0.4	0.0	0.3	-0.3	0.3	0.6
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.5	-0.7	0.3	0.0	-0.5
Weight	0.1	0.7	2.9	-1.7	-0.1	-0.4	0.4	0.4
Noisy workplace	0.1	0.1	0.3	0.4	0.5	0.1	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	-0.1	0.0	-0.8	0.2	0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.8	0.9	0.0	0.2	-0.1	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.6	0.3	-0.2	-0.2	0.5
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	0.5	0.1	-0.4	-0.2
Alcohol drinker status: Previous	0.1	0.2	0.4	0.0	0.4	-0.6	0.1	0.5
Hair Pigment	0.0	1.0	3.6	1.9	0.1	-1.1	-0.1	-0.4
Medication: Co-codamol	0.0	0.1	0.1	0.3	0.1	0.0	0.4	0.1
Alcohol usually taken with meals	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.4	0.2

Hub : Genes

FCHSD1

Models

Trait associations