Hub : Genes

SPTBN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0662	0.0356	1.1e-03	0.003	NA	0.007	NA	0.011	1.7e-01	NA	8.9e-02	NA	4.3e-02
2	GTEx	Small Intestine Terminal Ileum	0.2540	0.0820	1.6e-05	0.173	NA	0.189	NA	0.344	1.1e-04	NA	5.1e-05	NA	1.5e-08
3	TCGA	Pancreatic Adenocarcinoma	0.1100	0.0640	3.8e-04	0.119	0.068	0.057	NA	0.099	1.2e-05	0.00084	2.0e-03	NA	6.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	6.7	10.6	20.2	2.6	-2.1	-4.5
Bipolar Disorder or Schizophrenia	8.1	19.8	35.2	3.9	-3.0	-5.9
Depressed Affect (Nagel 2018)	0.5	1.2	2.9	0.3	0.7	-1.7
Depression (Nagel 2018)	0.7	1.0	2.1	1.4	-0.7	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.9	0.9	0.2	2.2
Neuroticism (Nagel 2018)	1.1	2.6	4.4	1.5	-1.1	-2.1
Schizophrenia (2018)	4.6	9.6	15.9	2.9	-2.1	-4.0
Schizophrenia vs Biploar Disorder	2.2	2.8	3.9	-2.0	1.4	1.6
Worry (Nagel 2018)	0.8	1.6	2.8	1.4	-1.7	-0.4
Alzheimer’s Disease (in mother)	1.1	1.2	3.3	0.4	-1.8	0.5
Alzheimer’s Disease (in father)	3.2	3.5	4.5	-2.1	2.1	1.3
Alzheimer’s Disease (including proxy)	0.5	0.8	1.8	-1.4	-0.1	0.7
Crohns Disease (2017)	0.1	0.2	0.2	0.4	-0.5	0.3
Irritable Bowel Disease (IBD)	0.6	1.4	1.9	1.1	-1.0	-1.4
Ulcerative Colitis (UC)	1.6	2.9	5.7	1.3	-1.1	-2.4
Major Depression (MDD)	0.3	0.4	0.6	0.3	-0.8	-0.7
Reaction Time	2.7	5.2	13.6	-3.7	1.1	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	0.3	0.2	1.2
Breast Cancer	5.0	12.0	21.6	4.7	-3.7	-0.8
Ovarian Cancer	0.8	1.0	1.8	0.9	-0.7	-1.3
Prostate Cancer	1.3	1.8	3.2	1.5	-1.8	0.1
Age at First Birth	3.7	5.4	7.4	-2.7	2.0	2.2
Bipolar Disorder (2011)	16.0	15.4	18.5	4.3	-3.8	-3.7
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	-0.8	1.0	0.3
Coronary Artery Disease (CAD)	0.8	1.0	2.4	1.6	0.2	-0.7
Crohns Disease (2012)	0.8	1.3	1.9	1.4	-1.2	-0.7
Mean Putamen Volume	0.6	0.7	1.1	-0.6	0.8	1.1
Fasting Glucose	0.1	0.1	0.2	-0.0	-0.3	0.5
HbA1C	0.5	0.6	1.4	0.5	0.4	1.2
HDL Cholesterol	0.3	0.4	0.8	-0.9	-0.5	0.5
LDL Cholesterol	1.5	2.3	2.8	-1.6	1.3	-1.7
Lupus	0.3	0.5	1.2	1.1	0.3	0.4
Neuroticism (2016)	0.3	0.4	1.1	1.0	-0.3	-0.3
Primary Biliary Cirrhosis	0.9	1.3	3.4	-1.8	0.7	-0.3
Rheumatoid Arthritis	1.3	1.8	2.4	-1.0	1.4	1.5
Schizophrenia (2014)	3.1	6.9	12.0	2.2	-1.9	-3.5
Triglycerides	1.4	2.4	5.1	-1.3	2.3	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.4	-0.0	-0.2
Ulcerative Colitis	2.9	4.3	9.3	1.5	-1.1	-3.1
Blood Eosinophil Count	0.1	0.7	1.6	1.3	-0.0	0.6
Blood Platelet Count	0.4	4.6	5.8	2.3	-2.4	-1.7
Blood Red Count	4.2	40.7	75.3	5.1	-4.5	-8.7
Blood White Count	0.8	5.9	10.3	3.2	-2.1	-1.7
Heel T-Score	0.5	3.9	9.2	-0.0	1.5	3.0
BMI	2.3	13.5	23.3	2.6	-3.2	-4.8
Height	2.4	47.0	100.0	-3.7	5.2	10.0
Waist Hip Ratio (WHR)	1.3	5.9	8.1	2.8	-1.3	-2.9
Systolic Blood Pressure	0.2	1.0	2.9	-1.7	-0.2	-0.1
Smoking Status	1.4	3.4	7.2	2.7	-0.7	-1.6
Allergy or Eczema	4.1	10.9	13.6	3.7	-2.6	-3.5
Cardiovascular Disease	2.0	6.6	11.0	1.9	-2.3	-3.3
Hypothyroidism (self reported)	0.2	0.4	1.2	-1.1	0.2	-0.0
Respiratory disease	1.6	3.6	9.0	-0.2	-1.3	-3.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.2	0.8	-0.6	-1.8
Lung FEV1/FVC ratio	1.0	5.3	7.0	-2.3	1.9	2.6
Lung FVC	3.2	16.1	44.6	6.7	-1.8	-0.7
Neuroticism	0.4	0.9	2.2	0.8	-0.0	-1.5
Chronotype (morning person)	7.0	16.1	23.6	-4.9	1.4	4.8
Hair Pigment	0.4	11.5	22.9	4.8	-3.3	-0.9
Tanning	0.2	2.4	5.6	-1.3	2.4	-0.1
Hand grip strength (left)	2.0	5.2	12.9	0.7	1.5	3.6
Number of treatments/medications taken	4.3	7.7	13.0	0.7	-3.1	-3.6
Average weekly spirits intake	0.5	0.6	1.3	-0.3	-1.1	0.6
Sensitivity / hurt feelings	0.2	0.4	0.6	0.8	-0.5	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	-0.7	0.5	0.1
Hearing difficulty/problems: Yes	6.6	10.1	10.8	3.1	-3.2	-3.3
Relative age of first facial hair	0.9	1.8	3.8	-0.4	-1.2	-2.0
Other serious medical condition/disability diagnosed by doctor	4.4	5.7	9.6	2.3	-1.5	-3.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.7	0.0	-0.1
Ever had hysterectomy (womb removed)	1.0	1.2	2.9	-1.7	-0.8	0.1
Systolic blood pressure, automated reading	0.3	0.7	1.5	-0.7	-1.2	-0.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.7	1.3	-1.6	-0.3
Angina	0.8	1.0	1.9	1.4	-1.0	-0.5
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	-0.6	0.2
Vitamin and mineral supplements	4.2	5.7	9.1	-3.0	2.5	1.3
Supplements: Zinc	0.5	0.5	1.2	0.4	-1.1	-0.3
Medication: Co-codamol	0.8	1.0	1.6	-1.2	0.2	-1.1
Medication: Metformin	0.3	0.4	0.5	0.5	-0.6	-0.7
Diabetes (father)	0.2	0.2	0.7	-0.2	-0.8	0.1
Diabetes (mother)	0.6	0.7	1.7	0.6	-1.3	-0.3
Severe depression (siblings)	1.7	1.9	3.8	1.9	-0.2	-1.4
Pack years adult smoking proportion	0.3	0.5	0.9	-0.9	0.8	-0.3
Impedance of leg (right)	8.1	39.1	51.2	-4.8	6.5	7.2
Leg fat-free mass (left)	0.5	2.6	3.0	1.4	-1.7	-1.7
Trunk fat percentage	0.2	0.9	1.8	-0.6	-0.7	-1.3
Hand grip strength (right)	2.4	6.4	14.2	-0.9	2.1	3.8
Townsend deprivation index at recruitment	0.6	0.9	1.2	0.8	-0.9	-1.1
Current tobacco smoking	0.2	0.4	0.5	-0.6	0.7	-0.5
Average weekly fortified wine intake	1.5	1.8	3.1	1.0	-1.8	-1.1
Maternal smoking around birth	1.0	1.5	1.8	1.1	1.2	-1.3
Fed-up feelings	1.8	3.2	6.4	-2.5	1.8	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.2	0.6	-0.7
Relative age voice broke	0.2	0.3	0.4	-0.6	-0.1	-0.6
Taking other prescription medications	3.1	4.7	10.6	0.9	-1.7	-3.3
Age when periods started (menarche)	0.2	0.4	1.0	-1.0	0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.3	-1.8	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.2	-0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.1	0.6	0.0	-1.4
Qualifications: CSEs or equivalent	3.6	4.8	5.6	-2.4	1.8	2.4
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.0	0.7	-1.0
High blood pressure	0.9	2.6	4.0	0.8	-1.8	-2.0
Hayfever, allergic rhinitis or eczema	1.7	3.8	5.3	2.1	-1.3	-2.3
Multivitamins +/- minerals	2.5	3.2	6.4	2.5	-1.4	-1.1
Stomach or abdominal pain in last month	2.7	3.3	6.0	1.4	-2.5	-1.4
Supplements: Glucosamine	3.2	4.2	8.6	2.9	-1.9	-0.5
Diverticular disease/diverticulitis (self-reported)	4.2	5.0	7.5	2.5	-2.7	-1.2
Medication: Atenolol	0.3	0.4	0.9	0.9	-0.5	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.7	-0.8	0.1	0.0
Sitting height	0.6	4.2	7.0	-0.8	2.2	2.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	-0.4	-0.5	-0.4
High blood pressure (mother)	1.6	2.2	5.7	0.8	-2.4	0.6
Body mass index (BMI)	3.0	12.8	23.8	2.1	-3.1	-4.9
Impedance of leg (left)	6.6	32.2	46.1	-4.1	5.8	6.8
Leg predicted mass (left)	0.4	2.3	2.7	1.3	-1.6	-1.6
Trunk fat mass	0.2	0.8	1.5	-0.2	-0.9	-1.2
Waist circumference	1.6	5.7	9.0	1.8	-2.2	-3.0
Number of incorrect matches in round	1.4	2.3	6.5	2.5	-0.1	0.7
Past tobacco smoking	2.1	3.9	7.1	-2.7	1.7	1.3
Alcohol usually taken with meals	1.9	3.1	7.2	2.7	-1.5	-0.2
Nervous feelings	2.4	4.4	8.5	-2.0	0.8	2.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	1.7	1.3	-0.9	-1.2
Hearing difficulty/problems with background noise	7.0	11.2	16.6	4.1	-2.2	-3.5
Hair/balding pattern: Pattern 2	0.9	1.1	2.4	-1.5	0.9	0.5
Had menopause	0.5	0.6	1.3	-0.7	-1.1	0.3
Had other major operations	0.0	0.1	0.1	0.1	0.2	-0.3
Forced vital capacity (FVC)	1.6	6.1	10.6	2.3	1.5	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.5	0.2	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.3	-1.0	-0.3
Qualifications: None of the above	2.4	5.2	11.8	-3.4	1.5	1.2
Financial difficulties in last 2 years	1.4	1.8	3.1	0.1	-1.5	-1.8
Mouth/teeth dental problems	0.4	0.6	1.1	-0.2	1.1	0.8
Heart attack	0.2	0.3	0.5	0.5	-0.7	0.4
Allergy	3.9	8.9	18.1	-2.2	1.9	4.2
Pain all over the body in last month	0.7	0.7	1.8	-0.4	1.4	-0.5
Diabetes (self-reported)	0.5	0.7	1.5	-0.8	0.1	-1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.6	0.3	0.5	-1.9
Medication: Ramipril	2.3	3.0	5.4	1.0	-1.6	-2.3
Medication: Simvastatin	0.5	0.8	1.2	-1.1	0.8	-0.7
Fluid intelligence score	0.2	0.5	1.4	-0.1	-0.3	1.2
Illnesses of siblings	1.1	1.5	3.2	-0.6	0.9	1.8
Neuroticism score	0.1	0.2	0.5	0.5	0.0	-0.7
Weight	0.3	1.3	2.3	0.6	-1.1	-1.5
Impedance of arm (right)	1.6	7.7	9.0	-2.7	3.0	2.6
Arm fat percentage (right)	2.7	10.6	24.1	1.2	-2.5	-4.9
Trunk fat-free mass	0.1	0.6	1.6	1.3	-0.5	0.0
Hip circumference	0.2	0.8	1.5	0.7	-1.2	-0.6
Time employed in main current job	0.1	0.1	0.3	-0.1	0.1	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.4	0.8	-0.1
Father’s age at death	0.3	0.4	0.7	0.7	-0.9	-0.2
Worrier / anxious feelings	0.2	0.3	0.9	0.1	-0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.5	-0.5	-0.3	-2.3
Falls in the last year	1.3	1.7	3.8	0.4	-1.1	-2.0
Hair/balding pattern: Pattern 3	4.4	6.5	7.6	2.8	-2.8	-2.1
Number of live births	0.7	1.0	1.4	0.5	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	9.9	2.2	1.3	3.1
Pulse rate	1.9	3.2	4.8	0.9	-2.2	-2.0
Happiness	2.4	2.9	5.9	1.4	-0.9	-2.4
Noisy workplace	1.2	1.5	4.2	-2.0	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.6	6.2	2.5	-1.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	1.2	0.1	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.2	-0.3	-0.5
Asthma	2.3	4.6	11.6	0.5	-1.4	-3.4
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.0	5.5	2.4	-2.2	-1.3
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.1	-0.4	-0.2
Depression (self-reported)	1.4	1.7	3.3	0.6	-1.8	-1.2
Medication: Lansoprazole	0.1	0.1	0.2	0.5	0.1	-0.3
Prospective memory result	0.2	0.2	0.3	-0.5	0.6	0.2
Lung cancer (father)	1.8	2.1	4.0	-1.5	2.0	-0.0
Illnesses of mother	1.9	2.4	6.8	-0.4	2.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	5.8	2.4	0.7	2.4
Pulse wave Arterial Stiffness index	1.5	1.8	4.0	0.8	-0.9	-2.0
Impedance of arm (left)	2.3	10.5	10.9	-3.1	3.3	3.3
Arm fat mass (right)	1.5	6.3	13.8	1.0	-2.1	-3.7
Trunk predicted mass	0.1	0.6	1.6	1.3	-0.4	0.0
Standing height	2.7	27.2	50.1	-3.3	4.5	7.1
Length of working week for main job	0.2	0.2	0.6	-0.8	-0.0	-0.2
Exposure to tobacco smoke at home	1.3	1.4	1.9	-1.4	1.3	0.9
Breastfed as a baby	0.6	0.7	1.9	-0.6	-1.4	0.2
Tense / ‘highly strung’	2.9	4.7	7.6	2.8	-2.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	7.3	11.2	21.3	1.6	-3.1	-4.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	0.2	0.4
Birth weight of first child	0.6	1.1	3.3	-0.1	-0.2	1.8
Peak expiratory flow (PEF)	1.7	3.9	6.8	2.0	0.8	2.6
Pulse wave reflection index	0.4	0.5	0.6	0.5	0.7	-0.8
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.6	-0.1	-1.6	-0.3
Loud music exposure frequency	0.0	0.0	0.1	0.2	0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	0.8	-0.6	-0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.6	-0.8	-0.6	-0.1
Blood clot in the leg (DVT)	1.1	1.4	2.2	-0.4	1.3	-1.5
Medication: Paracetamol	0.8	1.3	2.0	1.4	-0.4	-1.4
Headache pain in last month	1.6	2.7	5.0	0.6	-1.7	-2.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	-0.6	1.2	0.9
Glaucoma (self-reported)	0.0	0.0	0.1	0.1	0.3	-0.3
Gout (self-reported)	1.7	2.4	3.9	-1.2	1.3	2.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.5	-0.1	-0.3
Medication: Amlodipine	0.7	1.0	2.2	0.9	-1.5	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.1	-0.7	-0.3
Birth weight	0.6	1.3	2.6	-0.6	-1.0	-1.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.4	-0.1	1.5	0.9
High blood pressure (siblings)	1.6	2.4	2.8	1.5	-1.4	-1.7
Forced vital capacity (FVC), Best measure	1.4	5.0	9.0	2.1	1.3	3.0
Body fat percentage	0.4	1.7	4.2	-0.3	-0.9	-2.0
Leg fat percentage (right)	0.4	1.3	3.5	-0.3	-0.4	-1.9
Arm fat-free mass (right)	0.0	0.2	0.2	0.4	-0.2	0.5
Exposure to tobacco smoke outside home	1.1	1.5	3.8	-0.1	1.9	0.9
Comparative body size at age 10	0.5	1.5	2.3	-1.5	-0.4	1.4
Number of full brothers	3.0	3.8	6.2	2.5	-2.3	-0.2
Worry too long after embarrassment	0.9	1.4	3.3	-1.0	0.1	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	5.8	7.5	10.4	3.0	-1.9	-3.2
Wheeze or whistling in the chest in last year	2.6	4.7	10.4	1.1	-1.6	-3.2
Number of children fathered	0.3	0.4	0.8	0.3	-0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	8.8	3.0	-1.2	-1.3
Age at first live birth	0.2	0.3	1.0	0.1	-0.2	1.0
Pulse wave peak to peak time	2.2	2.6	5.8	-1.0	1.0	2.4
Health satisfaction	1.8	2.3	6.7	-0.3	-0.3	-2.6
Shortness of breath walking on level ground	2.6	3.0	5.8	0.3	-1.8	-2.4
Qualifications: College or University degree	3.4	10.8	27.3	5.2	-0.9	-2.0
Eye problems/disorders: None of the above	1.4	1.6	2.6	-1.6	0.8	1.2
Mouth/teeth dental problems: Loose teeth	1.9	2.3	4.9	2.2	-0.7	-1.2
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.1	-0.6	0.0
Medication for pain relief, constipation, heartburn	4.9	8.4	10.2	-2.8	2.6	3.2
Neck or shoulder pain in last month	1.0	1.4	3.7	-0.7	-0.1	1.9
Medication: Blood pressure	1.3	2.3	3.4	1.6	-1.8	-1.0
Angina (self-reported)	0.7	0.9	1.7	1.3	-1.0	-0.4
Migraine (self-reported)	2.2	2.7	6.0	0.5	-1.4	-2.5
Medication: Ibuprofen	1.5	1.8	2.5	1.6	-1.4	-1.0
Medication: Allopurinol	5.4	7.1	11.8	-2.3	2.0	3.4
Medication: Omeprazole	3.2	3.9	5.2	2.3	-1.2	-2.2
Medication: Seretide 50 evohaler	4.1	4.8	9.7	-3.1	2.0	0.7
Mean time to correctly identify matches	4.3	8.2	19.3	-4.4	1.8	1.4
Heart disease (mother)	1.5	1.9	2.3	1.5	-1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	1.3	-0.8	0.2
Whole body fat mass	0.4	1.6	3.5	0.2	-1.1	-1.9
Leg fat mass (right)	0.4	1.5	3.6	0.2	-0.9	-1.9
Arm predicted mass (right)	0.0	0.2	0.5	0.7	-0.4	0.3
Pulse rate, automated reading	0.4	1.2	3.4	-0.5	-0.2	-1.9
Alcohol intake frequency.	0.8	1.9	5.3	-2.3	0.1	-0.5
Comparative height size at age 10	1.7	9.2	22.2	-1.2	2.0	4.7
Number of full sisters	2.7	3.3	4.4	2.0	-1.2	-2.1
Suffer from ‘nerves’	0.9	1.5	3.0	1.2	-1.7	0.0
Overall health rating	3.0	6.4	18.7	0.1	-0.6	-4.3
Chest pain or discomfort	3.6	5.2	9.7	1.6	-1.8	-3.1
Had major operations	0.8	0.9	1.3	1.1	-1.0	-0.6
Age at last live birth	0.4	0.6	1.1	0.9	-1.0	-0.1
Family relationship satisfaction	0.2	0.3	0.5	-0.5	-0.3	-0.7
Leg pain on walking	0.8	0.9	2.6	0.4	-0.3	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.1	-1.5	0.9	-0.8
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.7	-1.0	-0.7	1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	1.0	-0.7	0.0
Medication: Aspirin	0.6	0.7	1.4	0.6	-1.2	-0.6
Supplements: Vitamin C	0.2	0.2	0.4	0.4	-0.6	0.3
Knee pain experienced in last month	0.0	0.1	0.1	-0.1	0.3	-0.4
Hypertension (Self-reported)	1.3	3.6	5.6	0.7	-2.4	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	1.0	-0.0	-0.2
Illnesses of father: Heart disease	2.3	3.2	3.7	1.5	-1.8	-1.9
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.5	-0.3	-0.1
Smoking status: Previous	0.8	1.3	2.2	1.5	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.3	12.0	-2.3	3.5	2.7
Whole body fat-free mass	0.2	1.2	2.1	1.5	-1.1	-0.6
Leg fat-free mass (right)	0.8	4.2	4.8	1.9	-2.2	-2.0
Arm fat percentage (left)	2.4	9.7	21.5	1.1	-2.5	-4.6
Average weekly red wine intake	7.8	11.6	24.1	4.9	-2.2	-2.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.8	-0.9	0.1
Mood swings	0.8	1.5	4.3	0.5	0.0	-2.1
Loneliness, isolation	0.7	0.9	1.6	1.0	0.3	-1.3
Long-standing illness, disability or infirmity	1.8	2.7	7.9	0.2	-0.5	-2.8
Ever had bowel cancer screening	0.4	0.5	0.9	0.6	-1.0	-0.4
Diabetes diagnosed by doctor	0.7	1.1	3.1	-0.4	-0.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	3.9	4.2	7.8	1.6	-1.4	-2.8
Friendships satisfaction	1.5	1.9	2.7	1.6	-1.0	-1.4
Qualifications: nursing, teaching	1.4	2.1	4.5	2.1	-1.4	0.2
Commuting to job workplace: Walk	0.4	0.4	0.8	0.6	-0.4	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.3	1.1	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	0.0	-0.2	1.0
Medication for cholesterol	0.4	0.6	1.4	1.2	-0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.7	1.6	-0.5	-0.8
Back pain experienced in last month	0.2	0.2	0.4	0.2	-0.5	-0.6
Mineral and other dietary supplements	3.7	5.0	10.8	-3.3	2.0	0.2
Breast cancer (self-reported)	1.3	1.6	3.5	-0.8	1.9	0.7
Asthma (self-reported)	2.2	4.4	10.5	0.2	-1.6	-3.2
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.3	0.4	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.9	-0.2	0.9	0.1
Medication: Aspirin	0.4	0.5	0.9	0.7	-1.0	-0.5
Medication: Gliclazide	0.8	0.9	1.5	0.4	-1.2	-1.1
Illnesses of father: None of the above (group 1)	3.1	3.8	6.6	-1.3	2.6	1.8
Smoking status: Current	0.2	0.2	0.4	-0.2	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	10.4	3.2	-0.7	-0.6
Whole body water mass	0.2	1.4	2.2	1.5	-1.1	-0.7
Leg predicted mass (right)	0.8	4.1	4.8	1.9	-2.2	-2.0
Arm fat mass (left)	1.4	5.9	12.5	1.0	-2.1	-3.5
Number of self-reported non-cancer illnesses	3.0	5.2	13.2	0.3	-1.6	-3.6
Average weekly champagne plus white wine intake	0.9	1.2	1.8	1.3	-1.4	0.4
Miserableness	0.5	0.8	1.5	1.2	0.1	-1.0
Guilty feelings	0.1	0.1	0.2	0.5	-0.2	0.2
Wears glasses or contact lenses	0.9	1.0	1.4	-0.6	-1.1	-1.2
Ever taken oral contraceptive pill	1.0	1.1	2.7	1.6	-0.6	0.4
Hearing aid user	0.6	0.7	1.4	0.6	-0.7	-1.2
Mother’s age at death	0.4	0.5	0.7	0.6	-0.8	-0.7
Financial situation satisfaction	0.7	0.9	1.6	-1.3	1.1	0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.0	-0.3	-0.9	-1.0
Commuting to job workplace: Public transport	1.0	1.2	2.8	1.7	-0.3	-0.9
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	-0.1	0.4	-0.1
Medication: Blood pressure	0.3	0.7	1.1	-1.1	0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.7	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	4.7	6.2	12.6	3.6	-2.4	0.4
High cholesterol (Self-reported)	0.3	0.5	1.4	-0.1	-0.0	-1.2
Medication: Bendroflumethiazide	0.8	1.2	2.8	0.0	-0.9	-1.7
Medication: Paracetamol	0.6	0.9	1.6	0.8	-0.6	-1.3
Medication: Lisinopril	0.6	0.8	1.2	0.3	-1.1	1.1
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	0.2	0.1
Illnesses of father: High blood pressure	0.6	0.7	0.9	0.9	-1.0	-0.7
Alcohol drinker status: Never	0.8	1.0	2.1	-1.4	-0.9	-0.4
Ever smoked	1.8	3.2	6.0	2.5	-1.6	-0.9
Basal metabolic rate	0.2	1.2	1.7	1.3	-1.1	-0.9
Leg fat percentage (left)	0.5	1.7	4.2	0.2	-0.9	-2.0
Arm fat-free mass (left)	0.0	0.2	0.5	0.7	-0.4	-0.0
Number of operations (self-reported)	0.7	1.0	1.6	-1.2	-0.2	-1.3
Average weekly beer plus cider intake	0.1	0.1	0.4	0.2	0.0	-0.6
Irritability	1.1	1.9	4.4	2.1	-0.5	-1.0
Risk taking	2.3	3.3	8.6	2.9	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	-0.1	0.2	-0.9
Fractured/broken bones in last 5 years	0.7	1.0	2.0	0.3	-1.4	-0.9
Age started oral contraceptive pill	0.4	0.5	1.4	0.3	-0.1	-1.2
Diastolic blood pressure, automated reading	0.1	0.2	0.2	0.3	-0.3	-0.5
Ever depressed for a whole week	0.6	0.7	1.4	-0.7	-1.2	-0.6
Unable to work because of sickness or disability	2.1	2.7	4.5	-2.1	1.8	0.6
Commuting to job workplace: Cycle	4.5	5.4	14.1	3.8	-1.3	-0.6
Myopia	1.3	1.9	3.9	2.0	-0.8	-1.0
Vascular/heart problems diagnosed by doctor	1.7	4.7	6.5	-1.5	2.3	2.6
Cholesterol lowering medication	0.8	1.2	2.0	-1.1	0.6	-1.4
Medication: Omeprazole (e.g. Zanprol)	4.8	5.8	8.2	2.9	-1.7	-2.5
Pain experienced in last month	0.2	0.3	0.8	-0.3	0.4	0.9
Supplements: Calcium	3.4	3.8	5.4	2.3	-2.2	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	-0.4	1.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.7	-0.9	0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	-0.5	1.5	-1.3
Heart disease (siblings)	0.4	0.5	0.8	-0.9	-0.3	-0.8
Alcohol drinker status: Previous	1.2	1.4	2.8	1.0	-1.7	-0.6
Pack years of smoking	0.3	0.5	0.9	-1.0	0.8	0.1
Impedance of whole body	4.9	24.8	30.2	-4.3	5.0	5.5
Leg fat mass (left)	0.5	2.0	4.2	0.5	-1.3	-2.0
Arm predicted mass (left)	0.0	0.2	0.4	0.6	-0.4	-0.1