TWAS hub - RIN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0320	1.9e-04	0.036	0.036	0.028	0.041	0.039	3.2e-05	3.0e-05	2.3e-04	8.7e-06	1.6e-05
2	GTEx	Whole Blood	0.2220	0.0630	7.6e-07	0.118	NA	0.102	NA	0.131	5.6e-11	NA	1.3e-09	NA	4.5e-12
3	METSIM	Adipose	0.0321	0.0167	8.5e-03	0.009	0.006	-0.001	0.009	0.003	1.5e-02	3.6e-02	4.3e-01	1.6e-02	1.0e-01
4	NTR	Blood	0.0990	0.0271	6.9e-10	0.045	0.040	0.037	0.045	0.042	3.3e-14	5.8e-13	4.2e-12	2.3e-14	2.1e-13
5	ROSMAP	Brain Pre-frontal Cortex	0.0346	0.0197	1.2e-02	0.031	0.002	0.027	0.008	0.022	6.0e-05	1.6e-01	1.8e-04	2.7e-02	6.4e-04
6	YFS	Blood	0.0451	0.0156	1.1e-06	0.030	0.023	0.033	0.032	0.032	4.3e-10	3.2e-08	6.5e-11	6.8e-11	1.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2011)	8.8	8.5	21.6	-4.7	-1.6	-2.4	-1.2	-3.9	-2.1
Medication: Gliclazide	5.3	6.0	10.7	-1.4	3.2	1.8	3.3	-0.8	3.1
Number of self-reported non-cancer illnesses	4.9	8.4	15.5	-0.3	3.9	1.8	3.9	1.7	3.7
Average weekly red wine intake	4.7	7.0	11.6	-1.3	2.7	2.9	2.3	-3.4	2.8
Average weekly champagne plus white wine intake	4.7	6.5	11.0	-0.7	-3.3	-1.8	-3.3	-1.6	-3.3
Medication: Allopurinol	4.0	5.3	17.3	4.2	-0.1	0.7	0.3	3.8	0.3
Commuting to job workplace: Cycle	3.9	4.7	15.2	-2.1	1.3	1.5	1.4	-3.9	1.6
Number of treatments/medications taken	3.6	6.4	14.1	-0.7	3.3	0.8	3.8	1.4	3.2
Taking other prescription medications	3.5	5.4	9.4	-0.2	2.9	1.6	3.1	1.9	3.0
Number of incorrect matches in round	3.3	5.4	19.3	-2.9	-1.6	-0.0	-1.0	-4.4	-1.1
Qualifications: College or University degree	3.2	10.1	38.2	-4.4	-1.0	0.4	-1.1	-6.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	3.1	3.7	7.6	-1.9	2.1	-0.1	2.8	-1.3	2.2
Bipolar Disorder (2018)	3.0	4.8	18.1	-4.3	-0.6	-2.1	-0.6	-2.1	-0.9
Schizophrenia vs Biploar Disorder	3.0	3.9	10.8	3.3	1.5	0.5	1.1	2.7	1.3
Medication: Amlodipine	3.0	4.1	9.1	1.1	2.3	1.4	3.0	1.1	2.5
Number of children fathered	2.9	3.3	5.2	-0.5	-2.2	-2.3	-1.9	-1.3	-2.1
Handedness (chirality/laterality): Left-handed	2.9	3.5	7.6	-2.7	-1.3	-0.1	-1.4	-2.8	-1.5
Long-standing illness, disability or infirmity	2.9	4.5	7.8	1.1	2.8	0.1	2.3	2.5	2.5
Eye problems/disorders: Glaucoma	2.9	3.4	6.0	0.3	2.4	2.4	1.8	-0.5	2.3
Bipolar Disorder or Schizophrenia	2.8	6.7	26.7	-5.2	0.3	-1.6	0.5	-3.2	-0.0
Supplements: Glucosamine	2.8	3.6	9.2	-0.4	2.3	1.3	3.0	-1.3	2.0
Glaucoma (self-reported)	2.8	3.2	6.2	0.5	2.3	2.5	1.6	-0.2	2.3
Exposure to tobacco smoke outside home	2.8	3.7	5.9	1.6	-2.0	-1.4	-2.0	1.9	-2.4
Vitamin and mineral supplements	2.7	3.7	6.2	1.4	-2.0	-1.2	-2.3	2.5	-1.8
Impedance of leg (right)	2.7	13.2	43.7	6.6	-1.1	1.9	-1.7	5.1	-1.1
Had other major operations	2.7	3.3	5.5	1.1	2.3	1.6	2.0	1.1	2.3
Cardiovascular Disease	2.5	8.3	18.0	0.3	3.9	1.3	4.2	2.1	3.3
Gout (self-reported)	2.5	3.4	11.5	3.4	-0.0	-0.1	0.2	3.0	0.2
Health satisfaction	2.5	3.2	6.9	-1.0	2.6	0.6	2.3	0.7	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	7.3	-2.7	-1.0	-1.9	-1.3	-1.8	-1.1
Fed-up feelings	2.3	4.1	16.2	2.9	0.3	-0.2	-0.4	4.0	0.0
Impedance of leg (left)	2.3	11.2	36.7	6.1	-1.6	1.5	-2.0	4.5	-1.6
Past tobacco smoking	2.3	4.3	7.9	1.4	-2.8	-0.9	-2.7	1.2	-2.4
Qualifications: None of the above	2.3	4.9	12.2	2.9	1.8	0.8	1.6	3.5	1.7
Medication: Simvastatin	2.3	3.4	7.3	0.7	1.7	1.6	1.9	2.7	1.7
Guilty feelings	2.3	3.4	10.7	-0.4	1.7	3.3	2.0	0.2	1.7
Heart attack/myocardial infarction (self-reported)	2.3	3.0	4.0	1.9	1.9	1.8	1.6	1.0	2.0
Multivitamins +/- minerals	2.2	2.8	4.4	-0.9	1.9	1.0	2.1	-2.0	1.7
Lung FVC	2.0	10.1	45.0	-3.0	0.9	-0.1	2.1	-6.7	1.0
Hearing difficulty/problems: Yes	2.0	3.0	12.3	-3.5	0.6	-0.2	0.4	-2.2	0.6
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.5	-0.6	2.5	-0.1	2.0	-0.0	2.2
Diabetes (self-reported)	2.0	3.1	5.9	1.4	2.1	0.9	1.7	2.4	1.7
Tense / ‘highly strung’	2.0	3.4	6.4	-1.9	-1.8	-0.8	-1.5	-2.5	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	11.3	-3.4	0.2	-1.9	-0.4	-1.8	-0.3
High cholesterol (Self-reported)	2.0	3.5	9.9	1.1	1.7	1.1	1.6	3.1	1.8
Unable to work because of sickness or disability	2.0	2.6	7.7	1.7	1.0	1.2	1.0	2.8	1.2
Impedance of whole body	2.0	10.2	31.9	5.6	-0.6	2.6	-1.3	4.5	-0.5
Hearing difficulty/problems with background noise	1.9	3.1	8.9	-3.0	1.5	1.3	1.5	-1.4	1.3
Mean time to correctly identify matches	1.9	3.6	7.9	1.5	1.1	2.8	1.4	2.6	1.3
Illnesses of father: None of the above (group 1)	1.9	2.4	4.2	-1.1	-2.0	-0.8	-2.0	-0.6	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.4	0.6	2.0	0.7	2.1	1.7	1.6
Medication: Co-codamol	1.8	2.0	6.1	0.1	1.4	0.3	1.4	2.5	1.4
Medication: Omeprazole	1.8	2.1	4.5	-1.4	1.6	-0.3	2.1	-0.7	1.7
Supplements: Fish oil (including cod liver oil)	1.8	2.4	9.5	-1.6	0.4	0.9	1.2	-3.1	0.2
Major Depression (MDD)	1.7	2.0	4.4	0.0	1.9	2.1	1.4	-0.0	1.6
Reaction Time	1.7	3.2	7.8	1.8	0.6	2.5	0.9	2.8	0.8
Type 2 Diabetes (T2D) (2018)	1.7	3.1	6.1	1.1	2.3	-0.1	2.5	1.7	1.8
Chronotype (morning person)	1.7	3.9	14.5	3.8	-1.3	0.8	-1.3	2.1	-0.7
Heart attack	1.7	2.2	3.3	1.8	1.5	1.7	1.1	0.8	1.6
Medication for pain relief, constipation, heartburn	1.7	2.9	6.0	1.1	-2.3	-0.8	-2.4	0.1	-2.1
Had major operations	1.7	2.0	2.7	-0.8	-1.6	-1.2	-1.6	-1.6	-1.5
Diabetes diagnosed by doctor	1.7	2.8	4.7	0.9	2.2	0.6	1.9	2.1	1.7
Alzheimer’s Disease (in father)	1.6	1.8	5.2	2.1	-0.4	0.2	-0.8	2.3	-0.3
Severe depression (siblings)	1.6	1.8	2.8	-1.3	1.6	1.3	1.7	-0.9	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.5	-0.5	-1.6	-0.6	-2.1	-0.8	-1.7
Medication: Cholesterol lowering	1.6	2.4	4.5	1.3	1.2	1.6	1.5	2.1	1.4
Blood clot in the leg (DVT)	1.6	2.0	3.8	0.5	1.9	0.5	1.9	1.4	1.6
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	4.0	-1.0	-1.6	-1.7	-2.0	-1.8	-1.5
Mineral and other dietary supplements	1.6	2.1	6.2	1.3	-0.8	-1.0	-1.7	2.5	-0.6
Irritability	1.6	2.7	5.7	-0.3	-1.7	-2.4	-1.9	-0.6	-1.9
Schizophrenia (2018)	1.5	3.2	10.3	-3.2	0.8	-0.4	1.1	-2.4	0.7
Worry (Nagel 2018)	1.5	3.1	4.7	-1.3	-2.0	0.0	-2.2	-2.0	-2.0
Maternal smoking around birth	1.5	2.1	4.2	-0.5	2.0	1.4	1.7	-0.0	1.9
Medication: Ibuprofen	1.5	1.8	3.6	-0.1	1.9	1.1	1.7	-0.2	1.7
Allergy or Eczema	1.4	3.8	6.9	-1.5	1.8	1.0	2.6	-2.5	1.7
Diabetes (father)	1.4	1.8	3.3	0.9	1.5	1.4	1.8	0.8	1.2
Average weekly fortified wine intake	1.4	1.6	2.7	-0.4	1.5	1.6	1.2	-0.7	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	3.7	0.5	-1.1	-1.9	-0.9	1.6	-1.1
Hypertension (Self-reported)	1.4	3.9	7.6	0.6	2.7	1.1	2.8	1.8	1.9
Smoking status: Previous	1.4	2.2	4.2	-0.8	2.0	0.8	2.0	-0.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	8.3	2.8	-0.3	0.8	-0.6	2.9	-0.5
Blood Red Count	1.3	12.9	37.6	-6.1	0.9	-4.2	1.0	-4.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	9.2	1.0	1.7	3.0	1.5	0.3	1.7
Allergy	1.3	3.1	5.4	2.3	-1.5	0.6	-2.1	2.1	-1.2
Father’s age at death	1.3	1.7	3.6	-1.9	-1.1	-0.1	-1.1	-1.9	-0.9
Pulse rate	1.3	2.1	3.8	-2.0	1.4	0.4	1.4	-1.6	1.5
Breastfed as a baby	1.3	1.7	7.0	-0.3	0.7	2.6	0.5	-0.9	1.2
Illnesses of father: Heart disease	1.3	1.8	3.5	1.0	1.9	0.6	1.6	0.6	1.7
Ever smoked	1.3	2.3	4.1	-1.5	1.9	0.2	2.0	-1.4	1.5
Number of operations (self-reported)	1.3	2.0	3.5	-0.9	1.8	1.0	1.8	0.1	1.9
Blood Eosinophil Count	1.2	9.0	21.8	2.9	3.0	4.7	2.6	1.4	2.5
Alcohol usually taken with meals	1.2	2.0	6.6	-0.8	-1.3	-0.4	-1.1	-2.6	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.9	-0.5	1.7	1.0	1.6	-0.7	1.4
Pulse wave Arterial Stiffness index	1.2	1.4	3.0	-1.4	-0.7	-1.7	-1.0	-0.9	-1.1
Pulse wave peak to peak time	1.2	1.4	3.0	1.7	0.5	1.6	0.7	1.1	0.8
Migraine (self-reported)	1.2	1.5	2.6	0.1	1.6	1.6	0.5	1.1	1.5
Illnesses of siblings: Diabetes	1.2	1.4	2.2	-0.6	-1.5	-1.5	-1.2	-0.7	-1.4
Medication: Blood pressure	1.2	2.2	6.3	1.7	1.6	-0.4	1.0	2.5	0.8
Alcohol drinker status: Previous	1.2	1.4	3.2	-1.3	1.1	0.8	0.8	-1.8	0.8
Coronary Artery Disease (CAD)	1.1	1.3	2.2	0.8	1.2	1.1	1.5	0.7	1.4
Rheumatoid Arthritis	1.1	1.6	2.3	1.3	1.3	0.6	1.5	1.4	1.2
Lung FEV1/FVC ratio	1.1	5.3	9.6	-0.5	-3.1	-2.6	-2.4	-0.1	-3.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.6	-0.2	1.6	-0.7	1.6	-0.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.9	1.4	1.5	2.4	1.3	1.0	1.4
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.1	-1.8	1.0	0.4	1.7	-2.5	1.1
Medication: Levothyroxine sodium	1.1	1.9	5.9	2.4	0.1	-0.1	-0.5	2.3	-0.2
Nervous feelings	1.1	2.0	3.4	1.7	-1.8	0.6	-1.6	0.6	-1.7
Time employed in main current job	1.1	1.2	3.1	1.5	0.6	1.1	0.3	1.8	0.5
Impedance of arm (left)	1.1	5.2	13.9	3.7	-0.1	2.7	-0.8	3.1	0.2
Medication: Paracetamol	1.1	1.8	3.1	-0.2	1.6	1.1	1.8	1.0	1.6
High blood pressure (siblings)	1.1	1.7	4.6	0.0	-1.1	-2.2	-1.4	0.3	-1.4
Neck or shoulder pain in last month	1.1	1.6	3.8	1.2	-0.8	-1.6	-0.5	2.0	-1.0
Overall health rating	1.1	2.4	7.8	0.0	1.0	-2.8	0.6	2.2	0.2
Friendships satisfaction	1.1	1.4	2.9	-0.9	1.3	1.7	1.3	-0.7	1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.3	2.1	-0.9	0.6	-1.1	1.9	-0.8
Medication: Bendroflumethiazide	1.1	1.7	5.1	-0.1	-1.2	-2.3	-0.9	1.0	-1.4
Medication: Paracetamol	1.1	1.6	2.8	-0.4	1.5	1.1	1.7	0.9	1.6
Supplements: Calcium	1.1	1.3	4.0	-0.0	0.7	2.0	1.2	-1.0	0.8
Average weekly spirits intake	1.0	1.2	2.4	-0.5	1.5	0.6	1.5	-0.5	1.3
Sensitivity / hurt feelings	1.0	1.7	4.3	-0.3	-1.7	-0.6	-2.1	-0.3	-1.7
Ever had hysterectomy (womb removed)	1.0	1.2	1.9	-1.0	1.4	-0.3	1.2	-0.9	1.3
Serious illness, injury or assault to yourself	1.0	1.2	2.0	1.1	1.4	0.1	0.9	1.3	1.1
High blood pressure	1.0	2.9	5.6	0.5	2.2	0.9	2.4	1.9	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.6	-0.7	0.9	1.6	0.9	-1.2	1.0
Medication: Atenolol	1.0	1.3	2.5	0.7	1.6	1.0	1.5	0.5	1.2
Had menopause	1.0	1.3	2.4	0.6	1.5	1.0	1.3	-0.3	1.6
Impedance of arm (right)	1.0	4.7	10.5	3.2	0.6	3.1	-0.1	2.6	0.9
Mouth/teeth dental problems: Dentures	1.0	1.7	5.0	1.4	-0.3	-2.2	-0.2	1.6	-0.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.6	-1.2	-1.2	-1.1	-1.0	-0.8	-1.2
Headache pain in last month	1.0	1.8	3.3	0.7	1.7	0.9	1.0	1.8	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.1	-1.6	-0.3	0.1	-0.3	-2.0	-0.5
Medication: Blood pressure	1.0	1.7	3.1	0.5	1.2	1.8	1.7	1.1	1.1
Supplements: Vitamin C	1.0	1.2	2.0	-0.5	1.3	1.0	1.4	-1.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.0	-1.7	0.7	-0.3	0.2	-1.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	8.1	-1.9	-0.1	0.3	0.6	-2.8	0.2
Risk taking	1.0	1.4	6.7	-0.9	0.2	-0.9	-0.2	-2.6	-0.4
Breast Cancer	0.9	2.1	10.4	-0.9	-0.2	1.2	-0.2	-3.2	0.1
Schizophrenia (2014)	0.9	1.9	6.9	-2.6	0.5	-1.4	0.8	-1.3	0.1
BMI	0.9	4.9	19.1	-2.9	0.2	-4.4	0.6	-1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	-0.2	1.4	0.2	1.6	0.1	1.6
Pack years adult smoking proportion	0.9	1.4	2.7	1.6	0.5	-1.4	0.7	1.7	0.3
Hand grip strength (right)	0.9	2.6	5.0	2.2	-1.5	-1.5	-1.5	0.8	-1.8
Body mass index (BMI)	0.9	3.7	14.2	-2.5	0.8	-3.8	1.1	-0.6	-0.1
Medication: Ramipril	0.9	1.2	2.2	0.5	1.4	0.3	1.4	0.5	1.5
Alcohol intake versus 10 years previously	0.9	1.4	2.8	1.6	-0.0	-1.7	0.1	1.6	-0.4
Number of live births	0.9	1.3	3.2	-1.8	0.7	0.3	0.9	-1.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.6	2.2	0.3	-0.1	0.1	2.4	0.1
Leg fat percentage (right)	0.9	3.3	15.1	0.7	0.0	-3.9	0.0	1.9	-0.9
Leg pain on walking	0.9	1.2	2.9	-0.6	1.5	0.3	1.7	-0.1	1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.7	1.3	-1.1	-0.8	-0.2	1.3	-1.0
Qualifications: nursing, teaching	0.9	1.5	3.4	-0.8	-1.3	0.8	-1.0	-1.8	-1.1
Commuting to job workplace: Public transport	0.9	1.0	3.0	-1.0	0.8	0.9	-0.2	-1.7	0.8
Medication: Atorvastatin	0.9	1.1	3.6	1.6	0.2	0.2	-0.1	1.9	0.2
Leg fat percentage (left)	0.9	3.3	16.6	0.3	-0.2	-4.1	-0.1	1.4	-1.1
Fractured/broken bones in last 5 years	0.9	1.2	1.8	-0.9	1.3	0.3	1.2	-1.1	1.3
Age started oral contraceptive pill	0.9	1.1	2.0	-0.5	-0.8	-1.4	-1.3	-1.1	-0.9
Myopia	0.9	1.2	2.4	-0.0	1.3	1.3	0.8	-1.0	1.5
Vascular/heart problems diagnosed by doctor	0.9	2.6	5.7	-0.3	-2.2	-0.4	-2.4	-1.5	-1.5
Cholesterol lowering medication	0.9	1.3	5.9	0.8	0.6	-0.8	0.1	2.4	0.6
Alzheimer’s Disease (in mother)	0.8	1.0	2.3	0.4	0.9	1.5	0.9	-0.2	1.3
Fasting Glucose	0.8	1.0	3.0	0.7	1.2	0.3	1.7	0.4	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.1	1.2	0.1	-0.9	0.3	1.8	-0.2
Ulcerative Colitis	0.8	1.2	4.7	-2.2	0.7	0.2	0.9	-0.3	0.9
Systolic Blood Pressure	0.8	4.1	11.8	2.7	1.4	-0.4	1.7	3.4	0.8
Age when periods started (menarche)	0.8	1.9	5.7	-0.6	-1.4	-1.0	-2.4	0.1	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	-0.6	1.3	-1.1	1.1	0.0	1.0
Qualifications: CSEs or equivalent	0.8	1.0	3.9	2.0	-0.2	-0.0	0.4	1.4	0.0
Pain all over the body in last month	0.8	0.8	1.8	0.3	0.8	0.2	1.2	1.3	1.0
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	-0.2	-1.3	-0.9	-1.5	-0.8	-1.3
Depression (self-reported)	0.8	0.9	4.1	-2.0	0.5	-0.0	0.3	-0.9	0.4
Prospective memory result	0.8	1.0	1.9	-0.8	-1.1	-1.4	-0.3	-1.1	-1.0
Exposure to tobacco smoke at home	0.8	0.9	3.6	0.8	0.5	-0.1	0.8	1.9	0.6
Number of full sisters	0.8	1.0	2.0	-1.3	1.1	-0.1	1.4	-0.4	1.1
Average weekly beer plus cider intake	0.8	1.1	4.5	0.9	-0.3	-0.9	-0.4	2.1	-0.6
Leg fat mass (left)	0.8	3.0	16.3	-0.3	0.0	-4.0	0.2	0.8	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	3.5	1.9	0.1	1.0	-0.3	1.2	0.4
Age at First Birth	0.7	1.0	2.8	0.7	0.5	1.7	0.6	1.3	0.7
Blood Platelet Count	0.7	7.8	13.1	-1.2	3.1	3.4	3.0	-1.5	3.6
Waist Hip Ratio (WHR)	0.7	3.3	8.8	1.4	3.0	-0.3	2.3	0.7	1.7
Smoking Status	0.7	1.7	3.0	-1.0	1.6	-1.5	1.7	-0.7	1.0
Hypothyroidism (self reported)	0.7	1.7	4.8	2.2	0.6	0.2	0.4	2.1	0.4
Medication: Metformin	0.7	0.9	1.6	0.8	1.2	0.3	0.9	1.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	0.8	0.4	1.2	0.5	1.8	0.3
Relative age voice broke	0.7	1.1	2.2	-0.8	-1.2	-0.1	-1.5	-1.0	-1.1
Waist circumference	0.7	2.4	9.8	-0.1	1.4	-3.1	1.3	1.0	0.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-0.5	1.3	0.5	1.1	-0.6	1.3
Mouth/teeth dental problems	0.7	1.1	4.4	-1.4	-0.3	0.5	-0.3	-2.1	0.2
Illnesses of siblings	0.7	1.0	2.7	0.1	1.0	1.6	1.1	-0.3	1.0
Standing height	0.7	7.0	27.8	5.3	0.1	0.6	-0.6	3.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.1	1.4	-0.1	-0.2	-0.3	1.8	-0.3
Leg fat mass (right)	0.7	2.9	15.2	0.1	0.2	-3.9	0.2	1.2	-0.8
Suffer from ‘nerves’	0.7	1.2	1.6	-0.1	-1.3	1.1	-1.2	-1.0	-1.2
Mood swings	0.7	1.3	2.6	1.1	-0.4	-1.5	-0.7	1.6	-0.8
Osteoporosis (self-reported)	0.7	0.9	1.9	-0.1	1.3	0.2	1.4	0.4	1.3
Illnesses of father: High blood pressure	0.7	0.9	1.6	0.2	1.1	1.1	1.3	-0.2	1.1
Pack years of smoking	0.7	1.1	2.7	1.3	0.1	-1.6	0.3	1.4	-0.1
Depressed Affect (Nagel 2018)	0.6	1.3	4.5	1.6	0.7	-0.3	0.3	2.1	0.2
Irritable Bowel Disease (IBD)	0.6	1.5	3.0	-1.1	0.9	1.3	1.7	0.7	1.3
Ulcerative Colitis (UC)	0.6	1.1	2.9	-1.7	0.7	0.6	1.2	0.1	1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.1	2.0	-0.5	0.1	-1.2	1.5	-0.5
LDL Cholesterol	0.6	1.0	4.3	-0.4	-0.5	-2.1	-0.6	0.7	-0.8
Heel T-Score	0.6	4.5	14.6	2.9	0.9	3.8	0.8	1.4	0.8
Relative age of first facial hair	0.6	1.2	4.8	-2.2	-0.1	0.1	-0.3	-1.5	0.2
Stomach or abdominal pain in last month	0.6	0.8	1.6	-0.7	1.0	0.5	1.3	-0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.0	-0.5	-1.3	-0.7	-1.2	0.1	-1.4
Fluid intelligence score	0.6	1.3	3.0	1.7	-0.9	0.1	-1.7	0.7	-0.8
Arm fat percentage (right)	0.6	2.5	8.4	-2.0	1.1	-2.9	1.2	0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.9	0.6	0.7	-0.4	0.6	2.0	0.7
Falls in the last year	0.6	0.8	1.7	-1.3	1.1	-0.1	0.7	-0.8	0.6
Arm fat mass (right)	0.6	2.5	11.0	-1.2	0.9	-3.3	1.1	0.5	-0.0
Body fat percentage	0.6	2.5	11.4	0.3	0.1	-3.4	0.0	1.7	-0.9
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	-1.4	0.5	-1.5	0.6	-1.1	0.2
Whole body fat mass	0.6	2.3	11.6	0.2	0.4	-3.4	0.4	1.3	-0.6
Alcohol intake frequency.	0.6	1.4	4.1	0.8	0.7	-2.0	0.8	1.6	0.4
Comparative height size at age 10	0.6	3.4	10.1	3.2	1.0	1.3	0.8	2.6	0.7
Age at last live birth	0.6	0.9	2.2	-1.5	-0.6	0.5	-0.4	-1.5	-0.4
Arm fat percentage (left)	0.6	2.4	10.4	-1.6	0.8	-3.2	0.8	0.4	-0.1
Eye problems/disorders: Cataract	0.6	0.6	1.4	0.6	-0.8	-1.2	-0.9	0.4	-0.7
Medication for cholesterol	0.6	0.9	3.6	-1.0	-0.6	0.4	-0.3	-1.9	-0.3
Osteoarthritis (self-reported)	0.6	0.8	2.1	0.7	0.6	-0.4	1.2	1.4	0.4
Mother’s age at death	0.6	0.7	1.5	-1.2	-0.7	-0.4	-0.7	-1.2	-0.6
Intelligence (Savage-Jansen 2018)	0.5	1.5	5.1	2.3	-0.0	1.4	-0.2	1.4	0.3
Crohns Disease (2017)	0.5	1.0	2.4	-0.1	0.5	1.5	1.3	1.0	0.8
Prostate Cancer	0.5	0.7	1.9	-1.4	0.3	1.1	0.4	-0.8	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	1.0	0.6	-1.1	0.6	1.0	0.3
Triglycerides	0.5	0.9	2.0	1.4	1.1	-0.2	0.5	1.2	0.6
Hand grip strength (left)	0.5	1.4	2.4	0.7	-1.4	-0.9	-1.2	-1.2	-1.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.5	1.2	0.0	-1.2	0.2	0.2	-0.2
Supplements: Zinc	0.5	0.5	1.3	-0.5	1.2	0.0	0.9	-0.5	0.7
Trunk fat percentage	0.5	2.1	7.5	0.8	0.3	-2.7	0.2	2.0	-0.6
Trunk fat mass	0.5	2.3	9.9	0.5	0.4	-3.1	0.4	1.6	-0.6
Financial difficulties in last 2 years	0.5	0.7	2.9	0.4	0.5	-1.7	0.3	1.0	-0.1
Neuroticism score	0.5	1.0	1.8	0.8	-1.1	-0.1	-1.4	1.1	-1.1
Asthma	0.5	1.1	3.1	-1.8	0.6	-1.0	1.1	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	8.8	-0.3	-0.6	-0.3	-0.1	-3.0	-0.6
Peak expiratory flow (PEF)	0.5	1.2	5.1	-0.1	0.6	-0.1	1.3	-2.3	0.4
Pulse wave reflection index	0.5	0.6	1.1	-1.0	-0.8	-0.4	-1.0	-0.5	-0.8
Loud music exposure frequency	0.5	0.6	2.2	0.6	0.5	-0.1	0.7	1.5	0.4
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.1	0.9	0.9	1.1	0.2	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	0.3	1.0	0.4	0.8	-0.7	0.9
Pulse rate, automated reading	0.5	1.5	3.6	0.1	1.6	0.4	1.3	1.0	1.9
Loneliness, isolation	0.5	0.6	1.1	0.9	1.1	0.3	0.8	0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.1	-1.1	0.1	-0.0	0.1	-1.5	0.4
Back pain experienced in last month	0.5	0.7	1.8	0.9	0.7	-1.0	0.3	1.4	0.3
Asthma (self-reported)	0.5	1.0	2.8	-1.7	0.6	-0.6	1.1	-0.6	0.7
Arm fat mass (left)	0.5	2.3	10.4	-1.1	0.8	-3.2	0.9	0.6	-0.1
Hearing aid user	0.5	0.6	3.1	-1.8	-0.2	0.2	-0.4	0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	-0.5	1.1	-0.4	0.9	0.3	0.9
Ovarian Cancer	0.4	0.5	1.9	-1.4	0.4	-0.0	0.6	-0.4	0.5
Height	0.4	8.4	34.2	5.8	-0.9	-0.3	-1.7	3.0	-1.8
Neuroticism	0.4	1.1	2.5	0.2	-1.1	-0.7	-1.6	0.7	-1.3
Current tobacco smoking	0.4	0.7	2.8	-0.2	0.5	-1.7	0.5	0.8	0.1
Weight	0.4	2.2	11.1	-0.1	0.7	-3.3	0.7	1.0	-0.3
Worrier / anxious feelings	0.4	0.7	2.0	0.2	-1.0	0.5	-1.4	-0.2	-1.0
Noisy workplace	0.4	0.5	1.3	-0.6	0.6	-0.1	1.2	0.8	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.9	-0.9	-0.3	1.4	-0.3	-1.4	0.0
Lung cancer (father)	0.4	0.4	0.9	-0.0	-0.7	-0.3	-1.0	0.9	-0.6
Birth weight of first child	0.4	0.7	1.8	-0.0	-1.4	0.3	-1.0	-0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.6	-1.3	-0.2	0.3	0.1	-0.9	0.0
Number of full brothers	0.4	0.5	1.2	-0.6	-0.9	-0.1	-0.5	-1.1	-0.6
Worry too long after embarrassment	0.4	0.6	2.6	0.5	-0.1	0.5	-0.7	1.6	-0.2
Heart disease (mother)	0.4	0.5	1.2	1.1	-0.5	-0.1	-0.7	0.9	-0.5
Family relationship satisfaction	0.4	0.5	2.4	0.3	0.1	0.6	-0.2	1.5	-0.2
Leg fat-free mass (right)	0.4	2.2	6.5	-2.0	0.4	-2.5	0.6	-1.5	-0.2
Ever had bowel cancer screening	0.4	0.5	2.1	-1.4	-0.1	-0.4	0.1	-0.8	0.1
Smoking status: Current	0.4	0.6	2.7	-0.3	0.4	-1.7	0.5	0.3	-0.0
Leg predicted mass (right)	0.4	2.2	6.2	-2.0	0.5	-2.5	0.6	-1.5	-0.1
Wears glasses or contact lenses	0.4	0.4	0.9	-0.7	-0.5	-0.9	-0.7	-0.0	-0.5
Financial situation satisfaction	0.4	0.5	2.0	0.2	0.6	-0.0	0.8	1.4	0.5
Pain experienced in last month	0.4	0.7	2.5	-0.6	-0.6	0.9	-0.5	-1.6	-0.1
Depression (Nagel 2018)	0.3	0.4	2.0	-0.2	0.5	1.4	0.2	-0.1	0.4
Neuroticism (Nagel 2018)	0.3	0.6	1.5	0.3	-0.8	0.0	-1.2	0.6	-1.1
HbA1C	0.3	0.3	0.7	0.8	0.5	0.8	0.3	0.1	0.4
HDL Cholesterol	0.3	0.5	2.2	-0.4	-0.1	1.5	0.2	-0.7	0.4
Neuroticism (2016)	0.3	0.4	0.9	0.8	0.3	0.9	-0.0	0.8	0.3
Respiratory disease	0.3	0.7	1.3	-1.1	0.7	-0.7	1.1	0.1	0.6
Medication for hormone replacement therapy	0.3	0.4	1.4	-0.7	-0.3	0.0	-0.6	-1.2	-0.2
Diabetes (mother)	0.3	0.4	1.1	1.0	0.2	-0.2	0.7	0.7	0.0
Leg fat-free mass (left)	0.3	1.7	6.5	-1.5	0.5	-2.6	0.6	-0.9	-0.1
Townsend deprivation index at recruitment	0.3	0.5	0.9	0.4	0.9	-0.9	0.9	0.3	0.4
Sitting height	0.3	2.1	10.0	3.2	0.3	-0.1	-0.3	1.5	0.2
High blood pressure (mother)	0.3	0.4	0.6	0.6	-0.8	-0.3	-0.7	-0.5	-0.8
Leg predicted mass (left)	0.3	1.6	6.3	-1.5	0.5	-2.5	0.5	-0.9	-0.2
Hip circumference	0.3	1.4	7.6	0.0	0.3	-2.8	0.4	0.9	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.6	0.7	-0.5	-0.4	0.0	-2.1	-0.5
Medication: Lansoprazole	0.3	0.4	0.8	-0.9	0.1	0.5	0.8	-0.1	0.6
Length of working week for main job	0.3	0.3	1.1	0.7	0.1	-0.4	-0.2	1.0	-0.1
Birth weight	0.3	0.6	2.4	-1.6	0.4	-0.4	0.5	0.2	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	7.0	0.4	-0.2	0.3	0.3	-2.6	-0.2
Arm fat-free mass (right)	0.3	1.3	7.3	-0.1	0.2	-2.7	0.3	-0.0	-0.6
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	0.9	-0.5	0.6	0.4	0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.3	0.7	-0.2	-0.0	-0.2	1.2	-0.1
Medication: Aspirin	0.3	0.4	1.0	0.5	0.6	0.1	0.6	1.0	0.5
Knee pain experienced in last month	0.3	0.5	2.0	-0.1	-0.3	-1.4	-0.3	0.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.2	0.6	0.4	0.8	0.5	0.6
Whole body fat-free mass	0.3	1.4	5.6	-1.2	0.4	-2.4	0.5	-1.1	-0.2
Breast cancer (self-reported)	0.3	0.4	2.0	0.6	-0.1	-0.1	-0.2	1.4	0.1
Whole body water mass	0.3	1.4	5.2	-1.2	0.5	-2.3	0.7	-1.1	-0.1
Medication: Lisinopril	0.3	0.4	1.3	0.3	0.3	1.1	0.7	0.5	0.3
Basal metabolic rate	0.3	1.5	7.0	-1.0	0.5	-2.6	0.6	-0.6	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.1	0.8	0.3	0.5	0.2	0.9
Crohns Disease (2012)	0.2	0.4	0.8	-0.9	0.1	0.7	0.8	-0.3	0.3
Lupus	0.2	0.2	0.7	0.1	0.2	0.5	0.6	-0.9	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.4	-0.4	-0.8	-0.3	0.9	-0.2
Blood White Count	0.2	1.1	2.8	-0.6	-0.9	-0.7	-0.7	-1.3	-1.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.0	-0.2	0.1	1.0	0.1	0.4	0.2
Systolic blood pressure, automated reading	0.2	0.6	2.2	0.8	0.2	-0.5	0.6	1.5	0.0
Angina	0.2	0.3	0.9	0.9	0.7	0.1	0.2	-0.0	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.3	0.4	0.4	0.4	-0.6	0.3
Forced vital capacity (FVC)	0.2	0.9	3.3	1.3	-0.1	-0.1	0.4	-1.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.5	0.4	-0.6	0.6	-0.3	0.5
Trunk fat-free mass	0.2	1.0	4.1	-0.8	0.4	-2.0	0.4	-0.9	-0.2
Happiness	0.2	0.2	0.6	-0.8	0.1	-0.8	-0.2	-0.4	-0.2
Illnesses of mother	0.2	0.2	0.3	-0.5	0.5	0.1	0.5	-0.6	0.4
Trunk predicted mass	0.2	1.1	4.4	-0.9	0.3	-2.1	0.3	-1.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.4	-0.5	-0.7	0.1	-0.6	-0.1	-0.6
Age at first live birth	0.2	0.4	0.9	-0.2	-0.9	0.7	-0.9	-0.2	-0.6
Angina (self-reported)	0.2	0.3	1.0	1.0	0.5	-0.1	0.2	0.1	0.5
Arm predicted mass (right)	0.2	1.2	6.9	-0.2	0.1	-2.6	0.1	-0.2	-0.6
Chest pain or discomfort	0.2	0.3	0.6	-0.8	0.4	-0.7	0.5	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.8	-0.3	0.7	0.1	-0.3	0.1
Medication: Aspirin	0.2	0.2	0.3	0.2	0.6	0.3	0.5	0.6	0.6
Ever taken oral contraceptive pill	0.2	0.2	0.8	0.9	-0.1	0.6	0.4	0.2	0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.2	0.5	-0.5	0.7	0.3	0.1
Arm fat-free mass (left)	0.2	1.2	6.1	-0.5	0.2	-2.5	0.5	-0.4	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.6	-0.1	0.9	-0.1	-0.5	0.0
Diastolic blood pressure, automated reading	0.2	0.6	1.1	0.8	0.5	-1.1	1.0	0.6	0.5
Heart disease (siblings)	0.2	0.2	0.9	-0.1	-0.5	0.2	-0.4	1.0	-0.2
Arm predicted mass (left)	0.2	1.1	5.6	-0.4	0.5	-2.4	0.7	-0.2	-0.2
Mean Putamen Volume	0.1	0.1	0.1	0.4	-0.3	-0.1	-0.1	0.2	-0.3
Hair Pigment	0.1	3.8	9.9	-2.7	1.1	0.7	1.3	-3.1	1.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.7	-0.2	0.5	-0.1	-0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.4	-0.2	-0.0	0.0	0.6	0.0
Comparative body size at age 10	0.1	0.4	2.0	0.2	-0.0	0.1	0.4	1.4	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.7	0.1	0.1	-0.8	0.0	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.3	-0.2	-0.1	-0.2	-0.5	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.3	0.0	0.2	0.5	-0.5	0.3	0.1
Miserableness	0.1	0.1	0.4	0.5	0.2	-0.2	0.3	0.6	0.1
Alcohol drinker status: Never	0.1	0.2	0.4	-0.5	-0.5	-0.1	-0.6	0.3	-0.2
Ever depressed for a whole week	0.1	0.1	0.3	-0.6	0.3	-0.1	0.1	-0.4	-0.1
Tanning	0.0	0.3	1.0	-0.3	-0.7	0.2	-1.0	-0.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.0	0.5	-0.2

Hub : Genes

RIN1

Models

Trait associations