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chr2:201,131,124-203,176,201

Best TWAS P=4.36e-17 · Best GWAS P=1.43e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CASP8	0.24	0.30	enet	14	0.32	6.6e-27	-6.7	7.9	2.6e-15	-0.87	0.14	0.86	FALSE
2	GTEx	Adipose Subcutaneous	ALS2CR12	0.19	0.11	enet	23	0.15	2.9e-12	-8.3	-7.0	2.1e-12	0.86	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	CASP8	0.20	0.16	lasso	7	0.15	2.7e-08	-8.2	7.7	1.0e-14	-0.85	0.01	0.99	FALSE
4	GTEx	Artery Aorta	CASP8	0.10	0.04	enet	19	0.06	2.6e-04	-3.5	5.1	2.9e-07	-0.47	0.13	0.20	FALSE
5	GTEx	Artery Aorta	ALS2CR12	0.23	0.18	enet	19	0.17	7.0e-10	-8.3	-7.5	4.4e-14	0.88	0.00	1.00	FALSE
6	GTEx	Artery Tibial	CASP8	0.07	0.07	enet	20	0.04	2.1e-04	-6.7	5.7	1.0e-08	-0.65	0.15	0.73	FALSE
7	GTEx	Artery Tibial	ALS2CR12	0.09	0.10	lasso	3	0.09	2.4e-07	-6.7	-7.0	2.2e-12	0.75	0.08	0.92	FALSE
8	GTEx	Brain Cerebellar Hemisphere	CASP8	0.58	0.50	lasso	3	0.46	1.9e-13	-7.6	-8.0	1.8e-15	0.90	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	CASP8	0.44	0.47	enet	7	0.46	4.2e-15	-8.2	-8.0	1.5e-15	0.89	0.00	1.00	FALSE
10	GTEx	Brain Cerebellum	ALS2CR12	0.28	0.16	enet	25	0.13	1.2e-04	-6.7	-7.2	6.4e-13	0.76	0.04	0.87	FALSE
11	GTEx	Brain Cortex	ALS2CR12	0.31	0.29	enet	15	0.27	4.2e-08	-6.7	-6.1	1.2e-09	0.68	0.09	0.88	FALSE
12	GTEx	Brain Frontal Cortex BA9	CASP8	0.13	0.24	lasso	1	0.21	3.1e-06	-7.6	-7.7	2.0e-14	0.91	0.02	0.94	FALSE
13	GTEx	Brain Frontal Cortex BA9	ALS2CR12	0.26	0.29	enet	8	0.24	5.1e-07	-6.7	-7.0	2.1e-12	0.77	0.04	0.94	FALSE
14	GTEx	Brain Hypothalamus	ENO1P4	0.33	0.02	lasso	13	0.00	3.9e-01	-6.6	6.0	1.5e-09	-0.68	0.03	0.48	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	ALS2CR12	0.15	0.15	lasso	8	0.14	1.6e-04	-8.3	-8.4	4.4e-17	0.99	0.01	0.97	TRUE
16	GTEx	Brain Putamen basal ganglia	ALS2CR12	0.46	0.44	lasso	2	0.40	1.9e-10	-6.7	-6.7	1.8e-11	0.71	0.18	0.81	FALSE
17	GTEx	Breast Mammary Tissue	CASP8	0.29	0.18	lasso	6	0.20	2.7e-10	-6.7	7.8	5.9e-15	-0.90	0.01	0.99	FALSE
18	GTEx	Breast Mammary Tissue	ALS2CR12	0.13	0.05	enet	10	0.07	2.3e-04	-6.7	-6.2	4.9e-10	0.71	0.04	0.93	FALSE
19	GTEx	Breast Mammary Tissue (Male)	CASP8	0.32	0.00	enet	35	0.15	2.0e-04	-1.5	5.2	2.1e-07	-0.35	0.04	0.43	FALSE
20	GTEx	Breast Mammary Tissue (Male)	ALS2CR12	0.35	0.06	lasso	4	0.03	5.8e-02	-6.7	-6.6	3.5e-11	0.70	0.04	0.28	FALSE
21	GTEx	Breast Mammary Tissue (Female)	CASP8	0.20	0.24	lasso	4	0.22	3.5e-07	-8.3	8.2	1.5e-16	-1.00	0.00	0.99	FALSE
22	GTEx	Breast Mammary Tissue (Female)	ALS2CR12	0.04	0.03	lasso	5	0.00	2.3e-01	-4.5	-6.7	2.2e-11	0.78	0.02	0.57	FALSE
23	GTEx	Cells Transformed fibroblasts	CASP8	0.30	0.35	lasso	6	0.35	2.6e-27	-6.7	7.4	1.2e-13	-0.83	0.95	0.05	FALSE
24	GTEx	Cells Transformed fibroblasts	STRADB	0.07	0.02	lasso	4	0.02	1.4e-02	-8.3	-7.5	4.5e-14	0.97	0.02	0.87	FALSE
25	GTEx	Cells Transformed fibroblasts	AC005037.3	0.08	0.00	enet	13	0.01	8.4e-02	-8.2	5.1	2.7e-07	-0.49	0.02	0.81	FALSE
26	GTEx	Colon Sigmoid	ALS2CR12	0.19	0.17	lasso	5	0.15	4.5e-06	-6.7	-6.8	1.4e-11	0.70	0.06	0.82	FALSE
27	GTEx	Colon Transverse	CASP8	0.21	0.13	lasso	7	0.17	2.1e-08	-6.7	7.8	5.5e-15	-0.89	0.01	0.99	FALSE
28	GTEx	Colon Transverse	ALS2CR12	0.19	0.16	lasso	4	0.14	5.8e-07	-6.7	-6.5	1.1e-10	0.70	0.19	0.79	FALSE
29	GTEx	Esophagus Mucosa	CASP8	0.22	0.17	lasso	6	0.20	4.5e-13	-8.2	7.8	4.7e-15	-0.82	0.01	0.99	FALSE
30	GTEx	Esophagus Muscularis	ALS2CR12	0.18	0.10	lasso	7	0.15	2.4e-09	-6.6	-6.4	1.2e-10	0.79	0.01	0.99	FALSE
31	GTEx	Heart Atrial Appendage	ALS2CR12	0.17	0.15	enet	11	0.12	8.0e-06	-6.7	-7.0	2.4e-12	0.75	0.05	0.94	FALSE
32	GTEx	Lung	CASP8	0.18	0.18	enet	20	0.18	9.6e-14	-6.6	7.2	9.0e-13	-0.81	0.03	0.97	FALSE
33	GTEx	Muscle Skeletal	CASP8	0.08	0.07	lasso	5	0.07	4.3e-07	-6.6	7.1	1.2e-12	-0.77	0.04	0.96	FALSE
34	GTEx	Nerve Tibial	ALS2CR12	0.13	0.11	lasso	4	0.08	1.4e-06	-6.7	-6.7	1.7e-11	0.71	0.12	0.87	FALSE
35	GTEx	Pancreas	CASP8	0.16	0.15	lasso	5	0.13	4.1e-06	-8.3	8.1	5.6e-16	-0.95	0.00	0.99	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	CASP8	0.26	0.24	enet	15	0.22	1.8e-12	-6.7	6.6	4.9e-11	-0.72	0.76	0.24	FALSE
37	GTEx	Skin Sun Exposed Lower leg	CASP8	0.24	0.22	enet	12	0.21	2.9e-17	-6.7	7.6	2.7e-14	-0.79	0.44	0.56	FALSE
38	GTEx	Spleen	CASP8	0.42	0.39	lasso	3	0.38	1.3e-10	-6.6	6.6	4.0e-11	-0.69	0.60	0.33	FALSE
39	GTEx	Stomach	CASP8	0.18	0.13	lasso	4	0.11	7.3e-06	-6.6	6.7	1.8e-11	-0.71	0.03	0.95	FALSE
40	GTEx	Testis	ALS2CR12	0.28	0.27	enet	11	0.28	9.4e-13	-6.7	-6.2	4.2e-10	0.77	0.09	0.91	FALSE
41	GTEx	Thyroid	ALS2CR12	0.19	0.12	enet	21	0.15	8.0e-12	-6.7	-6.6	4.4e-11	0.81	0.01	0.99	FALSE
42	GTEx	Whole Blood	CASP8	0.07	0.04	lasso	8	0.03	1.3e-03	-7.6	6.8	1.0e-11	-0.83	0.01	0.98	FALSE
43	METSIM	Adipose	ALS2CR12	0.08	0.07	lasso	8	0.07	2.5e-11	-6.7	-5.9	3.8e-09	0.68	0.14	0.86	FALSE
44	METSIM	Adipose	CASP8	0.20	0.20	lasso	12	0.19	1.2e-27	-6.7	6.9	5.1e-12	-0.75	0.82	0.18	FALSE
45	NTR	Blood	CASP8	0.04	0.04	lasso	9	0.04	4.0e-13	-6.7	6.7	2.0e-11	-0.71	0.81	0.19	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	CASP8	0.20	0.20	bslmm	368	0.20	5.5e-25	-8.2	-8.1	8.5e-16	0.86	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALS2CR12	0.03	0.04	enet	12	0.05	5.4e-10	-6.7	-6.2	7.4e-10	0.71	0.54	0.46	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CASP8	0.09	0.09	lasso	2	0.08	8.6e-05	-8.2	8.2	2.4e-16	-0.87	0.00	0.99	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	ALS2CR12	0.09	0.04	blup	76	0.04	2.2e-02	-6.2	-5.6	1.8e-08	0.76	0.02	0.60	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CASP8	0.07	0.06	lasso	3	0.06	1.6e-07	-8.2	8.3	9.5e-17	-0.90	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALS2CR12	0.05	0.03	blup	76	0.05	2.8e-06	2.8	-6.2	6.5e-10	0.80	0.23	0.76	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALS2CR12	0.13	0.04	blup	76	0.09	5.3e-06	-5.3	-5.4	7.4e-08	0.60	0.39	0.41	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALS2CR12	0.11	0.09	blup	76	0.09	1.4e-10	-6.7	-6.0	1.4e-09	0.71	0.84	0.16	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASP10	0.02	0.01	enet	3	0.02	3.1e-03	-3.2	5.2	2.4e-07	-0.76	0.03	0.83	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	ALS2CR12	0.04	0.04	blup	76	0.04	8.5e-06	-8.2	-5.9	4.6e-09	0.66	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	CASP8	0.07	0.10	enet	11	0.10	2.3e-11	-8.2	7.9	2.7e-15	-0.86	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CASP8	0.06	0.04	enet	8	0.06	5.1e-07	-8.2	7.8	6.1e-15	-0.90	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALS2CR12	0.06	0.06	enet	11	0.08	2.7e-08	-7.3	-5.9	3.5e-09	0.78	0.11	0.89	FALSE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	ALS2CR12	0.06	0.01	blup	76	0.03	4.4e-03	-7.7	-7.9	3.4e-15	0.88	0.01	0.90	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	CASP8	0.09	0.05	enet	12	0.09	7.0e-06	-8.2	6.4	2.0e-10	-0.70	0.01	0.98	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	ALS2CR12	0.11	0.11	lasso	6	0.11	1.3e-10	-6.7	-7.0	2.0e-12	0.79	0.02	0.98	FALSE