Hub : Genes

CASP10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.4050	0.0640	5.6e-17	0.365	NA	0.355	NA	0.336	1.8e-25	NA	1.1e-24	NA	3.5e-23
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2130	0.0550	6.3e-07	0.167	NA	0.170	NA	0.130	1.8e-09	NA	1.2e-09	NA	1.3e-07
3	GTEx	Skin Sun Exposed Lower leg	0.1020	0.0350	1.3e-04	0.089	NA	0.048	NA	0.077	8.0e-08	NA	7.6e-05	NA	6.0e-07
4	GTEx	Thyroid	0.1200	0.0440	3.8e-04	0.025	NA	0.028	NA	0.014	5.0e-03	NA	3.3e-03	NA	2.8e-02
5	METSIM	Adipose	0.0294	0.0141	5.6e-03	0.010	0.019	0.009	0.018	0.012	9.3e-03	0.00067	1.2e-02	0.00074	6.1e-03
6	NTR	Blood	0.0158	0.0080	4.8e-03	0.000	-0.001	0.000	-0.001	0.000	5.3e-01	0.77000	4.3e-01	0.71000	2.8e-01
7	TCGA	Esophageal Carcinoma	0.1860	0.0740	3.5e-04	0.041	0.088	0.091	NA	0.068	1.9e-02	0.00099	7.9e-04	NA	3.3e-03
8	TCGA	Brain Lower Grade Glioma	0.0232	0.0130	4.1e-03	0.012	0.015	0.018	NA	0.014	1.5e-02	0.00710	3.1e-03	NA	9.5e-03
9	TCGA	Thyroid Carcinoma	0.0530	0.0280	1.7e-04	0.028	0.024	0.031	NA	0.033	9.3e-04	0.00190	4.8e-04	NA	3.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	2.3	3.7	6.1	1.9	1.8	2.2	-2.0	-1.6	-1.9	1.2	-1.9	-2.5
Bipolar Disorder or Schizophrenia	1.0	2.4	5.1	1.1	2.3	2.2	0.0	-0.4	-1.1	2.2	-1.4	-1.5
Depressed Affect (Nagel 2018)	1.2	2.6	4.0	2.0	1.9	1.8	-0.8	-1.9	-0.3	1.5	-1.4	-1.8
Depression (Nagel 2018)	4.6	7.0	10.3	3.0	3.2	3.2	0.0	-2.5	-1.1	3.0	-2.9	-2.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.4	-0.5	-0.1	0.9	0.6	0.3	0.1	0.5	0.7
Neuroticism (Nagel 2018)	0.7	1.5	3.8	1.5	1.9	1.6	-0.3	-0.6	0.1	0.9	-1.3	-1.4
Schizophrenia (2018)	0.6	1.2	3.5	-0.2	1.5	1.1	1.8	0.8	0.2	1.9	-0.3	0.0
Schizophrenia vs Biploar Disorder	0.4	0.6	1.9	-0.9	0.4	-0.4	1.4	0.7	0.8	-0.3	0.6	0.9
Worry (Nagel 2018)	0.2	0.4	1.6	-0.3	0.7	0.2	-0.4	1.2	1.0	-0.3	0.7	0.1
Alzheimer’s Disease (in mother)	2.4	2.8	5.5	-2.3	-1.4	-1.5	0.3	1.6	1.9	-1.2	1.8	2.1
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.4	0.5	0.5	-0.8	0.6	0.0	-0.5	0.3	-0.7
Alzheimer’s Disease (including proxy)	0.8	1.2	3.4	-1.9	-0.6	-0.7	0.2	1.5	1.0	-0.4	1.4	1.0
Crohns Disease (2017)	0.5	1.2	4.1	-0.2	-1.2	-1.0	2.0	0.6	-0.7	0.8	0.5	1.5
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	1.0	-0.7	-0.2	1.6	0.1	-0.6	1.6	0.8	1.2
Ulcerative Colitis (UC)	0.4	0.8	2.9	1.7	0.1	0.7	0.0	-0.7	-0.1	1.7	0.4	0.1
Major Depression (MDD)	1.3	1.6	4.6	1.4	0.3	0.5	-1.7	-2.1	-0.1	-0.1	-1.7	-1.3
Reaction Time	0.1	0.2	0.5	-0.1	0.7	0.2	0.6	-0.4	-0.6	-0.2	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.8	-0.9	-1.7	-1.2	1.6	0.6	1.5	0.4	1.8	1.9
Breast Cancer	4.6	11.0	26.7	-3.0	-3.4	-3.1	0.7	3.4	4.4	-1.7	5.2	3.0
Ovarian Cancer	1.2	1.6	3.4	1.5	1.5	1.6	-0.8	-1.2	0.3	1.0	-0.9	-1.8
Prostate Cancer	5.5	7.7	10.8	-3.2	-2.9	-3.0	0.4	2.4	3.1	-2.3	3.3	3.2
Age at First Birth	0.6	0.9	3.7	1.1	0.3	0.3	-0.0	-1.5	-0.7	0.6	-1.9	-0.1
Bipolar Disorder (2011)	1.9	1.8	4.4	1.1	0.9	1.0	-2.1	-1.7	-1.2	0.9	-0.8	-1.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	-0.6	0.0	0.1	-0.9	1.0	1.1	0.3	0.4	-0.2
Coronary Artery Disease (CAD)	0.4	0.4	1.9	-0.5	-0.1	-0.1	0.4	-1.0	-0.1	1.4	0.8	0.2
Crohns Disease (2012)	1.3	2.1	5.1	-1.0	-2.2	-1.9	1.2	0.6	0.2	-0.1	1.8	2.0
Mean Putamen Volume	1.3	1.5	4.2	-0.6	-1.5	-1.3	-1.4	1.1	2.0	-0.8	0.9	0.8
Fasting Glucose	1.3	1.5	3.2	-1.2	-1.8	-1.5	0.3	0.8	1.6	-0.3	1.2	1.4
HbA1C	0.3	0.3	1.4	-0.6	0.0	-0.0	-0.3	0.8	-0.3	0.4	1.2	0.3
HDL Cholesterol	0.9	1.5	2.6	1.4	1.4	1.1	0.8	-1.1	-1.2	1.6	-1.4	-0.6
LDL Cholesterol	0.6	0.9	2.7	-1.0	-1.3	-0.7	-1.6	0.2	0.3	-1.2	0.6	0.4
Lupus	2.1	3.2	8.9	1.6	3.0	2.6	0.6	-0.8	-1.2	1.6	-1.3	-2.0
Neuroticism (2016)	0.4	0.5	1.5	-0.5	-0.6	-0.7	0.3	-1.2	1.0	-1.0	-0.1	0.5
Primary Biliary Cirrhosis	1.1	1.5	3.6	0.8	1.2	1.3	-1.7	-0.6	-0.1	-0.5	-1.9	-1.7
Rheumatoid Arthritis	3.3	4.5	15.5	1.7	2.3	1.8	2.0	-1.1	-2.5	3.9	-0.8	-1.2
Schizophrenia (2014)	0.3	0.7	1.7	-0.2	1.3	1.1	0.7	0.0	-0.1	1.2	-0.9	-0.5
Triglycerides	4.2	6.9	10.4	-2.9	-3.1	-2.9	0.5	2.2	3.2	-1.9	2.9	2.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	-0.2	0.4	-0.5	-0.2	-0.2	-0.1	0.3	0.8	0.2
Ulcerative Colitis	0.3	0.4	1.3	0.8	0.2	0.6	0.1	-0.5	-0.6	1.1	0.4	0.3
Blood Eosinophil Count	0.2	1.5	4.9	-0.2	-1.1	-1.1	-1.9	0.6	2.2	-1.3	0.4	0.3
Blood Platelet Count	1.3	14.6	53.9	-3.3	-2.1	-1.6	-4.1	1.5	3.7	-7.3	5.0	1.0
Blood Red Count	0.2	2.3	5.5	-0.7	-1.9	-1.9	2.3	1.1	-0.3	1.5	-0.3	2.0
Blood White Count	3.4	24.9	49.8	-5.7	-5.5	-5.3	2.5	3.4	4.8	-3.0	7.1	5.8
Heel T-Score	0.1	1.0	6.4	-0.9	0.2	-0.4	-0.4	-0.9	2.5	-0.5	-0.7	-0.3
BMI	0.2	0.9	2.6	0.4	-0.8	-0.5	-0.5	-1.2	0.0	1.6	-1.4	-0.9
Height	0.6	10.8	26.9	2.9	5.2	4.7	2.9	0.4	-3.2	4.2	-1.2	-1.5
Waist Hip Ratio (WHR)	1.4	6.4	11.2	2.7	3.4	2.9	0.5	-2.2	-2.4	1.6	-3.2	-2.6
Systolic Blood Pressure	0.1	0.5	1.4	-1.2	-0.8	-0.8	0.8	-0.6	-0.3	-0.8	0.6	0.1
Smoking Status	1.0	2.5	4.1	1.4	1.8	1.9	-1.9	-2.0	-0.1	0.3	-1.4	-2.0
Allergy or Eczema	2.2	5.8	12.4	2.7	3.5	2.9	-0.8	-0.8	-2.0	2.4	-2.3	-2.9
Cardiovascular Disease	1.7	5.6	11.2	-2.8	-2.3	-2.6	0.9	2.5	2.2	-3.3	1.8	1.8
Hypothyroidism (self reported)	1.1	2.6	14.0	1.1	1.4	1.5	0.9	-1.4	-0.6	3.7	-0.4	-0.7
Respiratory disease	2.2	5.0	10.2	-3.2	-2.7	-2.6	1.2	1.1	1.0	-1.5	2.2	3.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.1	-0.1	-0.5	0.4	0.7	-0.3	-0.8	-0.5	0.1
Lung FEV1/FVC ratio	0.5	2.5	4.6	2.1	2.1	2.0	1.0	-1.0	-0.7	0.8	-1.7	-2.0
Lung FVC	0.1	0.6	1.5	-0.3	0.6	0.2	1.2	1.1	-0.2	-1.0	-0.9	-0.3
Neuroticism	0.3	0.7	1.5	1.2	1.2	1.0	-0.4	-0.6	1.0	0.5	-0.3	-0.7
Chronotype (morning person)	0.5	1.1	2.8	-0.9	-0.2	-0.5	1.0	1.7	1.1	0.4	1.4	1.3
Hair Pigment	0.2	5.5	8.6	2.6	2.4	2.5	-0.4	-2.8	-1.7	1.8	-2.9	-2.9
Tanning	0.0	0.4	0.8	-0.3	-0.9	-0.7	-0.1	0.6	0.5	0.4	0.6	0.9
Hand grip strength (left)	0.6	1.6	3.2	1.7	1.8	1.4	0.1	-0.2	-0.6	1.4	-1.7	-1.1
Number of treatments/medications taken	1.0	1.9	3.4	-1.5	-1.8	-1.7	-0.0	0.9	1.2	-1.2	1.8	1.2
Average weekly spirits intake	0.1	0.1	0.5	-0.7	0.5	0.3	-0.2	0.4	0.4	-0.5	0.0	-0.0
Sensitivity / hurt feelings	0.2	0.3	1.5	0.1	0.2	0.3	0.2	0.3	1.0	-1.2	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	1.6	2.3	6.8	1.2	2.1	1.6	2.6	0.2	0.6	2.0	-0.8	-0.1
Hearing difficulty/problems: Yes	0.5	0.7	1.6	-1.1	-1.3	-1.1	-0.9	0.1	0.6	0.2	1.0	0.6
Relative age of first facial hair	0.7	1.4	4.0	0.9	2.0	1.9	-0.6	-0.7	0.7	-0.3	-1.0	-1.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.3	1.4	0.9	1.1	-0.6	-2.3	-0.9	1.3	-1.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.9	-1.3	-1.4	-1.0	0.9	0.6	0.5	-0.6	0.9	1.2
Ever had hysterectomy (womb removed)	1.4	1.5	4.5	-1.1	-0.3	-1.0	1.3	2.1	0.7	-1.8	0.5	1.1
Systolic blood pressure, automated reading	0.2	0.6	2.0	-0.6	-0.6	-0.3	-1.4	-0.0	-0.0	-1.3	0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.5	0.8	1.5	1.2	-0.9	-0.1	-1.0	-0.7	-1.2	-1.9
Angina	0.3	0.4	1.5	0.3	0.3	0.5	-0.5	-1.2	-0.5	-0.2	0.8	-0.9
Medication for hormone replacement therapy	1.3	1.4	9.0	0.8	0.9	0.6	3.0	0.5	-0.0	1.0	0.2	0.9
Vitamin and mineral supplements	0.7	1.0	2.2	-1.5	-1.4	-1.2	-1.0	0.2	0.4	-1.0	0.6	0.7
Supplements: Zinc	1.4	1.6	4.3	0.7	1.5	0.9	0.4	-1.3	-1.8	2.1	-0.7	-0.9
Medication: Co-codamol	0.3	0.4	1.3	-1.1	-0.5	-0.3	0.7	-0.2	-0.3	0.9	0.1	0.8
Medication: Metformin	0.6	0.8	1.6	0.8	0.3	0.7	-0.8	-1.0	-1.3	-0.9	-0.9	-1.2
Diabetes (father)	0.4	0.5	1.4	0.8	0.7	0.7	0.7	-1.2	-0.4	0.6	-0.5	-0.6
Diabetes (mother)	0.5	0.7	1.5	-0.8	-1.0	-1.1	-0.7	0.9	0.3	-1.2	0.1	0.4
Severe depression (siblings)	0.2	0.2	0.9	-0.1	-0.2	-0.0	0.1	0.8	0.7	-0.1	-0.9	0.3
Pack years adult smoking proportion	0.3	0.5	3.3	0.5	0.4	0.4	0.5	-0.2	-0.7	1.8	0.2	-0.2
Impedance of leg (right)	0.3	1.5	3.1	-0.9	-1.3	-1.3	-0.1	0.6	1.4	-1.4	1.2	1.8
Leg fat-free mass (left)	0.8	4.2	11.6	1.7	2.2	2.0	1.6	-0.0	-2.2	3.4	-2.2	-1.6
Trunk fat percentage	0.1	0.6	2.0	-0.4	-1.4	-1.1	-0.9	-0.2	0.2	0.8	-0.3	-0.1
Hand grip strength (right)	0.5	1.4	4.9	1.3	1.2	0.9	0.6	1.2	-0.6	2.2	-1.0	-0.4
Townsend deprivation index at recruitment	0.6	0.8	1.8	0.9	1.4	0.9	-0.8	-0.3	-0.8	-0.3	-1.1	-1.1
Current tobacco smoking	2.1	3.5	8.3	1.8	2.9	2.7	-0.4	-1.9	-0.7	0.6	-1.7	-2.2
Average weekly fortified wine intake	1.0	1.1	4.6	-0.4	-0.2	0.4	-1.3	2.1	0.7	-1.6	0.5	-0.3
Maternal smoking around birth	1.5	2.2	4.4	1.5	1.5	1.6	-0.8	-1.4	-0.8	2.1	-1.4	-1.9
Fed-up feelings	0.2	0.4	1.9	0.7	0.5	0.4	-0.2	-1.4	0.1	0.5	-0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.8	1.5	2.4	1.9	1.3	-1.2	-0.7	1.8	-1.9	-1.4
Relative age voice broke	0.3	0.4	2.6	-0.2	-0.4	-0.2	-1.6	-0.1	-0.5	-0.8	-0.2	-0.2
Taking other prescription medications	0.8	1.2	3.2	-1.3	-1.8	-1.7	0.8	-0.2	-0.2	0.7	0.7	1.1
Age when periods started (menarche)	0.8	2.0	8.7	-0.4	0.6	0.0	3.0	2.2	-0.3	0.1	1.4	1.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.5	-0.4	-1.0	-0.8	1.6	1.1	0.9	-1.0	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	7.6	-2.3	-2.5	-2.8	0.4	-0.3	2.2	-1.4	1.7	1.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.9	0.4	1.1	0.5	-1.4	-1.1	-0.4	-0.6	-0.8	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	2.6	0.4	0.2	-0.0	-1.1	-0.6	-0.7	-1.2	-1.6	-1.1
Serious illness, injury or assault to yourself	0.8	1.0	2.9	0.7	0.4	0.2	1.3	-0.7	-1.4	1.7	-1.2	0.1
High blood pressure	0.3	0.8	3.3	-1.0	-1.0	-0.7	-0.5	0.7	0.5	-1.8	-0.2	-0.3
Hayfever, allergic rhinitis or eczema	3.2	7.0	13.9	3.1	3.7	3.0	-0.5	-1.3	-2.0	2.9	-2.4	-3.2
Multivitamins +/- minerals	0.3	0.4	1.3	-0.0	-0.2	-0.5	0.7	0.5	1.2	-0.5	0.6	0.6
Stomach or abdominal pain in last month	1.3	1.6	4.2	-1.0	-2.1	-1.8	-1.8	-0.4	1.1	-0.2	0.4	1.0
Supplements: Glucosamine	1.2	1.6	5.1	-0.7	-0.3	-0.7	2.1	2.2	0.0	-0.3	1.2	1.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.7	1.5	0.3	0.5	-0.6	-1.1	-0.8	1.6	-1.4	-1.1
Medication: Atenolol	0.1	0.2	0.5	-0.5	0.2	0.0	-0.7	0.6	0.1	-0.2	0.4	-0.3
Medication: Levothyroxine sodium	0.3	0.5	2.2	-0.5	-0.6	-0.3	0.4	0.5	0.4	1.5	0.3	0.7
Sitting height	0.5	3.7	13.0	-0.0	2.0	1.5	3.6	2.0	-0.9	2.9	0.2	0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.7	0.3	-0.8	-0.9	0.0	-1.3	0.8	0.3	-0.1	0.3
High blood pressure (mother)	0.3	0.5	1.4	0.3	-0.2	-0.1	-0.5	-0.7	-1.2	0.9	-1.1	-0.1
Body mass index (BMI)	0.3	1.3	2.9	0.7	-0.3	0.0	-1.5	-1.7	-0.2	1.0	-1.5	-1.6
Impedance of leg (left)	0.2	1.0	2.4	-0.8	-0.9	-1.2	-0.0	0.4	0.8	-1.1	1.1	1.5
Leg predicted mass (left)	0.8	4.3	11.9	1.7	2.3	2.1	1.7	-0.0	-2.2	3.5	-2.2	-1.6
Trunk fat mass	0.1	0.6	3.0	0.5	-0.3	-0.0	-0.4	-0.4	-0.5	1.7	-1.1	-0.8
Waist circumference	0.7	2.6	5.7	1.6	1.2	1.4	-1.2	-1.3	-1.2	1.4	-2.4	-2.3
Number of incorrect matches in round	0.4	0.7	2.4	0.9	0.6	0.7	-1.6	-0.7	0.3	-0.7	-0.4	-0.9
Past tobacco smoking	0.4	0.7	5.2	-0.2	0.5	0.2	0.9	-0.1	-2.3	0.4	0.2	-0.2
Alcohol usually taken with meals	0.4	0.7	3.0	-0.4	-1.0	-0.6	0.5	0.8	0.8	-1.7	-0.1	0.5
Nervous feelings	0.9	1.6	4.5	-1.4	0.4	-0.2	-1.2	2.1	1.2	-2.0	0.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.4	0.8	1.1	0.7	0.9	-1.3	-0.2	2.1	-1.0	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	2.2	-0.5	-0.4	-0.8	-0.9	-1.5	-0.4	0.2	-0.8	-0.2
Hair/balding pattern: Pattern 2	1.7	2.2	6.3	1.3	1.3	1.0	1.7	-0.1	-1.9	2.5	-1.5	-0.6
Had menopause	0.7	0.9	2.1	0.5	1.4	1.4	0.4	0.2	-1.4	1.2	-0.1	-0.3
Had other major operations	0.7	0.8	2.7	0.5	0.8	1.0	0.1	0.3	-1.6	1.6	-0.4	-0.3
Forced vital capacity (FVC)	0.4	1.4	6.3	-0.4	1.0	0.4	2.5	2.0	-0.6	0.4	-0.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	7.7	-2.2	-2.7	-2.8	1.2	0.6	2.0	-1.2	2.0	1.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.4	1.3	1.8	1.5	0.2	-0.4	-0.3	1.6	-0.8	-1.2
Qualifications: None of the above	0.6	1.2	6.4	0.5	-0.6	-0.5	-1.6	-2.5	-0.8	-0.2	0.2	-0.5
Financial difficulties in last 2 years	1.0	1.4	3.7	0.9	0.9	0.8	-0.3	-1.9	-0.7	1.0	-1.8	-1.4
Mouth/teeth dental problems	0.8	1.3	6.6	1.0	0.7	0.5	1.5	-0.4	-0.6	2.6	-0.7	-0.0
Heart attack	0.4	0.5	1.1	0.3	0.8	0.2	1.0	-1.0	-1.0	-0.1	-0.9	-0.3
Allergy	0.8	1.9	6.0	-1.4	-1.8	-1.3	0.4	0.5	0.8	-2.5	0.9	1.5
Pain all over the body in last month	1.8	2.0	4.7	1.8	0.8	1.4	-0.1	-1.6	-1.3	2.2	-0.8	-1.6
Diabetes (self-reported)	0.7	1.0	2.0	0.8	0.2	0.2	-1.3	-1.4	-0.3	-1.3	-1.4	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	0.9	1.2	0.6	-0.1	-0.2	-0.8	0.6	-0.3	-0.7
Medication: Ramipril	1.1	1.4	2.0	-1.4	-1.4	-1.3	0.9	1.3	-0.7	-1.1	1.1	1.1
Medication: Simvastatin	0.7	1.1	1.7	-1.0	-1.1	-1.3	1.1	0.8	1.0	-0.9	1.1	0.9
Fluid intelligence score	1.0	2.1	6.5	-0.3	-0.9	-0.9	2.5	1.7	1.4	0.3	1.4	2.0
Illnesses of siblings	3.9	5.5	11.2	3.4	2.3	2.9	-1.2	-1.7	-1.9	2.5	-2.2	-2.4
Neuroticism score	0.3	0.7	3.2	-0.6	-0.2	-0.5	0.1	0.3	1.8	-1.0	0.9	0.7
Weight	0.4	2.1	6.8	1.2	1.2	1.3	0.2	-0.6	-1.3	2.6	-1.8	-1.5
Impedance of arm (right)	1.1	5.3	9.5	-2.6	-2.4	-2.3	1.1	2.4	1.3	-2.0	2.7	3.1
Arm fat percentage (right)	0.2	0.8	3.2	-0.6	-1.8	-1.3	-1.1	-0.8	0.5	0.2	-0.5	-0.2
Trunk fat-free mass	1.5	8.6	15.1	2.8	3.9	3.6	1.5	-0.7	-2.8	3.8	-3.1	-2.6
Hip circumference	0.1	0.3	1.0	-0.1	-0.5	-0.2	-0.4	0.6	-0.1	1.0	-0.4	-0.4
Time employed in main current job	0.2	0.3	1.6	-0.0	0.5	0.2	-0.0	-0.4	-1.3	0.0	-0.7	-0.2
Alcohol intake versus 10 years previously	0.2	0.2	1.0	0.1	-0.9	-1.0	0.3	-0.1	0.1	-0.3	-0.0	0.1
Father’s age at death	1.1	1.5	4.1	1.5	1.9	2.0	-1.0	0.5	0.7	0.3	-0.6	-1.3
Worrier / anxious feelings	0.2	0.3	0.9	-0.9	-0.4	-0.4	0.3	0.4	0.5	-0.1	0.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.3	0.7	0.6	0.4	-1.1	-0.0	1.1	-0.5	-1.0
Falls in the last year	0.8	1.1	4.1	1.0	-0.5	-0.0	-1.8	-2.0	0.8	0.4	-0.2	-0.8
Hair/balding pattern: Pattern 3	1.2	1.8	3.3	-1.6	-1.8	-1.7	-1.2	-0.4	1.7	-0.9	1.1	1.0
Number of live births	0.1	0.2	0.6	0.8	-0.0	0.3	0.0	-0.7	0.1	0.5	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.8	0.4	1.4	0.9	2.4	1.4	-1.3	0.8	-1.3	-0.4
Pulse rate	1.0	1.7	4.3	1.5	2.1	1.4	-0.0	-0.4	-0.6	0.1	-1.7	-1.8
Happiness	0.1	0.2	0.6	-0.5	0.3	-0.1	-0.2	0.1	-0.8	0.7	-0.3	-0.1
Noisy workplace	3.8	4.7	10.7	-2.3	-2.9	-3.0	0.1	1.4	1.0	-0.9	2.1	3.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.7	1.7	2.0	2.2	-0.8	0.3	-1.2	0.8	-1.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.2	-0.1	-0.6	0.2	-0.3	0.6	-0.1	-0.2	-0.0
Mouth/teeth dental problems: Dentures	0.6	1.1	3.4	-1.1	-0.7	-0.2	-1.0	-0.3	0.6	-1.6	1.8	0.5
Asthma	2.0	3.9	6.8	-2.5	-2.2	-2.2	1.6	1.2	1.6	-0.7	2.4	2.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.3	-1.0	-1.1	-0.2	0.6	1.1	-0.4	0.0	0.8
Medication: Cholesterol lowering	0.5	0.8	2.5	-0.9	-0.8	-0.7	-1.6	-0.5	1.3	-0.8	0.8	0.2
Depression (self-reported)	0.2	0.3	1.6	0.3	-0.3	-0.4	-0.4	-0.1	0.2	1.3	-0.4	-0.2
Medication: Lansoprazole	1.2	1.4	3.4	-1.6	-1.8	-1.7	0.3	1.3	0.8	-0.5	0.5	1.1
Prospective memory result	0.3	0.4	2.1	0.4	0.3	0.4	0.9	-1.4	-0.2	0.4	0.0	-0.0
Lung cancer (father)	0.4	0.4	1.2	0.1	-1.0	-1.0	-1.1	-0.4	-0.3	-0.3	-0.5	-0.1
Illnesses of mother	0.4	0.5	1.5	1.1	0.4	0.5	-0.6	-1.2	0.8	0.0	-0.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	9.3	0.9	1.8	1.2	3.0	1.0	-1.6	1.4	-1.4	-0.4
Pulse wave Arterial Stiffness index	0.3	0.3	1.0	0.9	0.3	0.7	-1.0	-0.2	-0.1	-0.1	-0.6	-0.5
Impedance of arm (left)	1.5	6.8	13.5	-2.6	-3.0	-2.9	1.3	2.7	1.6	-1.6	3.1	3.7
Arm fat mass (right)	0.2	0.7	1.6	0.5	-0.3	0.1	-0.7	-0.9	-0.4	1.2	-1.2	-1.1
Trunk predicted mass	1.4	8.2	14.5	2.8	3.8	3.6	1.4	-0.7	-2.7	3.6	-3.0	-2.5
Standing height	0.7	7.0	13.6	1.6	3.6	2.9	3.5	2.1	-2.8	3.7	-1.0	-0.2
Length of working week for main job	0.1	0.2	0.5	-0.7	-0.3	-0.3	0.4	-0.3	-0.4	0.4	0.5	0.1
Exposure to tobacco smoke at home	0.5	0.6	2.1	-0.9	-0.5	-0.8	-0.1	-1.0	-1.4	-0.5	-0.5	0.2
Breastfed as a baby	0.6	0.7	2.3	0.1	0.0	0.1	0.8	-1.1	-1.1	1.5	-0.6	-1.0
Tense / ‘highly strung’	0.7	1.2	3.7	-0.6	-0.2	-0.7	-0.6	1.9	1.8	-0.5	1.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.2	0.9	1.4	1.1	1.4	-0.6	0.5	2.3	-0.6	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.8	-0.3	-0.3	-0.8	0.9	0.3	-1.1	1.0	0.2
Birth weight of first child	0.7	1.3	5.9	0.6	1.1	1.4	2.4	0.6	-0.8	0.8	0.6	0.5
Peak expiratory flow (PEF)	0.9	2.1	6.3	1.0	1.1	0.7	2.5	1.1	-1.3	1.9	-1.6	-0.5
Pulse wave reflection index	1.9	2.3	4.4	-1.6	-2.1	-1.7	0.7	1.2	1.3	-1.1	1.6	1.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	-0.2	0.7	0.4	-1.1	1.3	0.8	-0.1	-0.7	-0.3
Loud music exposure frequency	0.3	0.3	1.3	-0.7	-0.6	-0.4	-0.5	0.0	-0.2	1.1	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.0	0.8	0.8	0.9	0.0	1.4	0.5	-0.4	-0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.6	0.3	0.6	0.6	-0.6	-0.6	-1.9	-0.6	-1.0	-1.1
Blood clot in the leg (DVT)	2.2	2.9	6.6	-1.7	-1.6	-1.5	0.8	2.4	1.2	-0.3	2.6	1.8
Medication: Paracetamol	0.4	0.7	2.9	0.1	0.3	0.2	-1.7	-1.4	0.7	-0.6	-0.2	-0.9
Headache pain in last month	1.0	1.8	4.4	-0.5	-1.5	-1.5	-2.1	-0.9	1.5	-1.9	0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.4	0.5	0.3	0.5	0.0	-0.7	0.4	-0.5	-0.2
Glaucoma (self-reported)	0.2	0.3	0.9	0.1	-0.5	-0.1	-0.4	1.0	0.8	-0.5	0.5	0.0
Gout (self-reported)	0.2	0.3	0.8	0.4	0.2	0.2	-0.2	-0.8	-0.4	-0.9	-0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	6.1	0.1	0.4	0.7	0.4	-0.7	0.2	2.5	0.1	-0.0
Medication: Amlodipine	1.2	1.6	6.0	-1.3	-1.0	-0.9	-0.6	2.0	0.7	-2.5	-0.3	0.7
Medication: Ventolin 100micrograms inhaler	2.8	3.6	7.7	-1.8	-2.2	-2.4	1.4	1.4	0.9	-1.6	1.8	2.8
Birth weight	0.9	2.0	6.0	1.0	1.4	1.0	1.6	1.0	-2.5	1.8	-0.9	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.6	0.5	0.1	-0.2	-0.5	-1.3	0.1	-0.5	-0.6	-0.6
High blood pressure (siblings)	5.3	7.7	13.9	-3.7	-3.3	-3.7	1.2	2.7	1.9	-2.2	2.1	3.0
Forced vital capacity (FVC), Best measure	0.5	1.8	9.5	-0.1	1.2	0.5	3.1	1.6	-0.8	1.1	-0.7	0.5
Body fat percentage	0.2	0.8	2.4	-0.3	-1.6	-1.2	-1.2	-0.8	0.5	0.6	-0.3	-0.2
Leg fat percentage (right)	0.3	1.2	3.3	0.3	-1.3	-0.9	-1.8	-1.5	0.9	0.3	-0.9	-0.8
Arm fat-free mass (right)	1.2	6.0	11.8	2.4	3.2	2.8	1.2	-0.6	-2.3	3.4	-2.6	-2.2
Exposure to tobacco smoke outside home	0.4	0.6	1.3	-1.0	-0.3	-0.8	0.6	-0.5	0.0	-1.1	1.0	0.7
Comparative body size at age 10	0.3	0.8	3.7	-0.6	-1.0	-0.7	-0.0	-0.3	1.9	-0.2	0.9	0.7
Number of full brothers	0.4	0.5	2.4	0.2	0.4	0.1	0.8	-0.3	-0.4	0.4	-1.6	-0.8
Worry too long after embarrassment	0.0	0.1	0.2	0.0	-0.2	-0.3	0.2	0.5	0.1	-0.2	-0.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.2	1.0	1.1	0.9	0.8	0.1	0.3	2.1	-0.6	-0.3
Wheeze or whistling in the chest in last year	2.2	4.0	7.7	-2.7	-2.5	-2.8	0.6	1.6	1.1	-1.8	1.4	2.3
Number of children fathered	0.4	0.5	1.6	0.4	0.1	0.1	-1.2	-0.8	-0.7	-0.1	-0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	0.4	1.0	0.6	-0.0	0.2	0.0	0.3	-0.4	-0.7
Age at first live birth	0.6	1.0	2.3	1.2	1.3	1.0	0.7	1.5	-0.7	0.6	-1.1	0.1
Pulse wave peak to peak time	0.2	0.3	1.2	-0.6	0.0	-0.3	1.1	0.2	-0.0	0.4	0.4	0.4
Health satisfaction	0.5	0.6	1.8	0.6	0.3	0.2	-1.1	-0.1	0.7	0.6	-1.3	-1.0
Shortness of breath walking on level ground	0.6	0.7	2.1	0.6	0.5	0.6	-0.7	-1.4	-1.0	0.7	-0.9	-0.8
Qualifications: College or University degree	0.4	1.3	3.6	-0.4	-0.4	-0.4	1.9	1.5	1.5	0.2	1.0	1.3
Eye problems/disorders: None of the above	1.6	1.8	3.7	1.8	1.6	1.3	-0.0	-1.0	-0.2	1.9	-1.5	-1.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.3	0.1	0.5	-0.0	0.0	0.1
Emphysema/chronic bronchitis	3.2	3.6	6.9	1.9	2.6	2.4	-0.3	-0.7	-1.9	1.7	-2.3	-1.9
Medication for pain relief, constipation, heartburn	0.8	1.3	2.8	1.1	1.7	1.5	1.3	0.9	-1.1	1.3	-0.5	-0.3
Neck or shoulder pain in last month	1.1	1.5	5.8	-0.9	-0.8	-0.8	-1.9	-0.6	1.1	-2.4	0.4	0.1
Medication: Blood pressure	0.1	0.1	0.4	0.0	0.5	0.5	0.0	-0.2	0.1	-0.2	-0.5	-0.6
Angina (self-reported)	0.2	0.3	1.0	0.1	-0.0	0.1	-0.5	-1.0	-0.4	-0.3	0.9	-0.5
Migraine (self-reported)	0.2	0.3	0.8	0.8	-0.3	-0.1	0.9	0.4	0.5	0.6	0.1	0.3
Medication: Ibuprofen	0.7	0.8	1.8	-0.6	-1.2	-1.3	0.2	0.9	1.3	-0.3	0.2	1.0
Medication: Allopurinol	0.5	0.7	2.0	-0.1	-0.4	-0.1	-1.0	-1.1	-1.1	-1.4	-0.6	-0.7
Medication: Omeprazole	0.3	0.4	1.8	-0.1	-0.7	-0.8	1.4	0.5	0.3	-0.0	0.3	0.5
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-1.4	-1.0	-1.0	-0.3	0.7	0.7	-0.4	0.7	0.9
Mean time to correctly identify matches	0.1	0.2	0.5	-0.5	0.3	0.3	-0.5	-0.7	-0.4	-0.6	0.3	-0.7
Heart disease (mother)	0.7	0.8	2.1	-1.1	-0.3	-0.6	0.8	1.4	-0.6	0.1	1.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	4.7	0.6	0.6	0.5	1.1	-0.6	-0.8	2.2	0.0	-0.2
Whole body fat mass	0.2	0.7	3.1	0.5	-0.2	0.0	-0.5	-0.7	-0.5	1.8	-1.1	-0.8
Leg fat mass (right)	0.3	1.1	2.8	1.0	-0.2	0.1	-1.1	-1.3	-0.0	1.7	-1.4	-1.2
Arm predicted mass (right)	1.2	5.9	11.4	2.4	3.3	2.7	1.3	-0.4	-2.2	3.4	-2.6	-2.1
Pulse rate, automated reading	0.5	1.6	4.6	0.8	1.9	1.4	-0.0	-0.9	-0.6	0.1	-1.6	-2.1
Alcohol intake frequency.	1.8	4.2	8.4	-2.0	-2.7	-2.9	-0.7	1.4	0.4	-2.5	2.0	2.1
Comparative height size at age 10	0.4	2.3	4.9	0.6	2.2	1.9	1.8	1.6	-1.2	2.0	-0.6	-0.2
Number of full sisters	0.4	0.4	1.4	-0.6	-1.2	-0.9	-0.9	-0.8	0.0	-0.1	0.0	0.0
Suffer from ‘nerves’	0.2	0.3	0.7	-0.6	0.0	-0.3	0.7	0.7	0.6	-0.0	0.9	0.6
Overall health rating	0.3	0.6	2.7	0.3	0.6	0.5	0.3	-1.6	-0.1	0.7	-0.1	-1.1
Chest pain or discomfort	0.3	0.5	1.1	-0.9	-0.7	-0.4	0.6	0.3	0.6	-0.7	1.1	0.7
Had major operations	0.8	0.9	1.8	1.1	0.7	0.8	-0.3	-1.0	-1.3	0.0	-1.2	-1.3
Age at last live birth	1.1	1.7	4.3	1.8	2.1	1.6	0.5	0.3	-0.4	1.5	-1.4	-0.5
Family relationship satisfaction	0.6	0.8	2.3	-0.3	0.2	-0.1	0.7	-0.9	-1.5	1.4	-1.0	0.3
Leg pain on walking	0.2	0.2	0.9	0.5	0.6	0.3	0.4	-0.1	0.1	1.0	-0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.1	0.6	-0.4	-0.3	-1.8	-0.3	0.2	-0.2	-1.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	0.6	0.9	0.9	0.1	-0.9	-0.4	1.1	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.9	-1.2	-1.2	-0.6	-0.5	1.0	0.1	-1.4	1.1	0.6
Medication: Aspirin	1.1	1.4	3.4	0.4	0.3	0.9	-1.8	-1.9	-1.1	-0.5	-1.0	-1.4
Supplements: Vitamin C	0.7	0.8	2.3	0.8	1.1	1.2	-0.5	0.2	-1.5	0.8	0.4	-0.6
Knee pain experienced in last month	1.1	1.6	4.8	-1.4	-0.9	-0.9	-1.6	0.5	1.5	-2.2	1.1	0.2
Hypertension (Self-reported)	0.4	1.0	4.6	-1.1	-0.9	-0.8	-0.5	0.9	0.7	-2.2	-0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-0.1	-1.1	-0.9	0.0	1.0	-0.3	0.4	-0.1	0.5
Illnesses of father: Heart disease	0.1	0.2	0.5	-0.5	0.5	0.3	0.4	-0.5	-0.5	-0.4	-0.2	-0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-1.1	-1.1	-0.9	-0.8	-0.4	0.9	-1.2	0.7	0.3
Smoking status: Previous	0.9	1.3	6.1	-0.5	-1.4	-1.2	-0.7	0.7	2.5	-0.4	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.1	-0.7	0.8	-0.0	2.0	1.6	-0.9	0.8	0.2	0.6
Whole body fat-free mass	1.2	6.9	13.0	2.4	3.3	3.1	1.5	-0.5	-2.7	3.6	-2.8	-2.2
Leg fat-free mass (right)	0.9	4.9	11.7	1.8	2.6	2.3	1.5	-0.1	-2.6	3.4	-2.2	-1.9
Arm fat percentage (left)	0.2	0.8	3.1	-0.3	-1.8	-1.3	-1.1	-0.8	0.4	0.5	-0.5	-0.2
Average weekly red wine intake	0.2	0.3	1.1	-0.5	0.2	0.3	1.0	0.9	0.4	-0.1	-0.2	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.4	0.4	0.6	-0.2	-0.4	-0.5	-0.2	0.4	-0.2
Mood swings	0.1	0.1	0.9	0.2	-0.1	0.1	-0.1	-0.2	0.9	0.4	0.2	0.4
Loneliness, isolation	0.5	0.7	1.8	-1.4	-0.2	-0.6	1.1	0.9	0.2	0.0	1.2	1.0
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4	-0.3	0.3	0.1	-0.1	-0.3
Ever had bowel cancer screening	1.6	1.8	5.6	-0.8	-1.8	-1.4	-1.3	-0.5	2.4	-1.1	1.1	1.0
Diabetes diagnosed by doctor	0.4	0.6	1.4	0.6	0.3	0.3	-1.2	-0.8	-0.6	-0.5	-1.1	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-1.1	-0.3	-0.6	0.2	0.5	0.6	-0.6	0.9	1.0
Friendships satisfaction	0.6	0.7	1.5	0.3	0.9	0.8	1.0	-0.3	-0.9	1.2	-1.2	0.1
Qualifications: nursing, teaching	0.3	0.5	2.4	-0.4	0.0	0.2	1.5	0.6	0.5	0.5	0.2	1.2
Commuting to job workplace: Walk	0.5	0.6	2.4	0.4	-0.0	0.4	-1.6	0.2	0.2	-1.1	-0.9	-0.5
Eye problems/disorders: Cataract	4.0	4.6	9.1	-3.0	-2.4	-2.2	-0.2	0.8	1.4	-2.8	2.6	2.1
Mouth/teeth dental problems: Mouth ulcers	3.5	5.5	9.7	-2.5	-3.1	-2.8	-1.1	2.1	1.9	-3.0	1.7	2.1
Medication for cholesterol	0.8	1.2	4.7	0.9	0.4	0.4	-2.2	-0.9	-0.2	0.3	-1.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	0.4	0.9	0.8	-0.4	-0.3	1.0	-0.2	-0.5	-1.0
Back pain experienced in last month	0.6	0.9	1.5	-0.7	-1.2	-1.2	-1.2	-0.7	0.8	-1.1	0.5	0.4
Mineral and other dietary supplements	0.2	0.3	1.1	-0.4	-0.5	-0.3	-0.8	-0.7	1.1	0.2	0.6	-0.0
Breast cancer (self-reported)	1.9	2.2	7.1	1.6	1.3	1.1	-1.4	-1.0	-1.5	0.0	-2.7	-1.5
Asthma (self-reported)	2.3	4.5	7.9	-2.7	-2.3	-2.3	1.6	1.1	1.7	-1.0	2.6	2.8
Osteoporosis (self-reported)	1.3	1.6	4.5	1.0	1.0	0.9	1.9	1.1	-2.1	1.2	0.3	0.6
Osteoarthritis (self-reported)	5.5	7.2	10.5	-3.1	-3.2	-3.2	0.5	1.9	2.5	-3.0	2.6	2.7
Medication: Aspirin	0.9	1.1	3.9	0.2	0.1	0.6	-2.0	-1.6	-0.6	-0.7	-0.7	-1.4
Medication: Gliclazide	0.8	0.9	2.0	1.1	-0.1	0.2	-0.8	-1.3	-1.0	-0.1	-1.4	-1.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	1.1	1.1	1.1	0.3	0.4	0.8	0.5	-0.1	-0.2
Smoking status: Current	1.8	2.9	6.8	1.7	2.6	2.5	-0.3	-1.8	-0.5	0.4	-1.5	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	-0.3	0.4	0.0	1.4	1.4	0.1	-0.6	0.2	0.1
Whole body water mass	1.2	6.8	12.0	2.2	3.4	3.1	1.4	-0.5	-2.7	3.5	-2.8	-2.3
Leg predicted mass (right)	1.0	5.2	12.5	1.9	2.7	2.4	1.4	-0.2	-2.6	3.5	-2.3	-2.0
Arm fat mass (left)	0.2	0.7	1.8	0.5	-0.3	-0.1	-0.8	-0.9	-0.5	1.4	-1.3	-1.0
Number of self-reported non-cancer illnesses	1.4	2.4	5.5	-1.2	-2.3	-2.1	1.0	1.2	1.7	-0.4	1.4	1.7
Average weekly champagne plus white wine intake	1.4	1.9	4.2	-1.8	-1.8	-1.5	-0.5	1.0	0.7	-2.0	1.3	0.9
Miserableness	0.3	0.6	2.0	0.5	0.4	0.4	-0.9	-1.4	0.7	-0.6	-0.6	-1.0
Guilty feelings	0.2	0.2	0.7	0.4	0.7	0.6	0.7	0.0	0.1	0.8	-0.1	-0.0
Wears glasses or contact lenses	0.3	0.3	1.0	-0.4	0.0	0.4	-1.0	-0.5	-0.1	-0.9	0.4	-0.3
Ever taken oral contraceptive pill	1.0	1.1	1.8	-0.5	-0.9	-1.0	1.3	1.3	1.2	-0.6	0.7	1.4
Hearing aid user	0.5	0.6	1.5	-1.2	-0.8	-0.7	-1.0	0.8	0.3	-0.6	0.5	0.6
Mother’s age at death	0.5	0.6	2.0	-0.2	1.0	1.2	-0.3	1.4	0.1	-0.2	-0.5	-0.4
Financial situation satisfaction	1.4	1.8	4.8	0.6	1.2	0.5	0.9	-1.4	-1.7	1.5	-2.2	-1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.4	1.4	-0.0	0.8	-2.5	-1.2	-0.2	0.6	-0.8	-1.2
Commuting to job workplace: Public transport	0.6	0.7	1.9	0.4	0.9	0.9	0.2	1.4	-0.4	0.2	-1.4	-0.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.1	1.4	1.2	1.5	-0.5	0.9	-0.6	-0.2	-0.2	-1.0
Medication: Blood pressure	0.2	0.5	1.4	-0.8	-0.4	-0.2	0.8	1.2	-0.5	-0.5	0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	0.9	1.0	0.9	-1.6	-0.9	0.6	0.0	-0.7	-1.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	-0.4	-0.3	-0.3	1.0	1.0	-0.3	-0.7	-0.1	0.9
High cholesterol (Self-reported)	1.7	3.0	6.0	-2.4	-2.2	-2.0	0.6	1.2	1.2	-1.6	2.0	1.5
Medication: Bendroflumethiazide	0.5	0.8	2.6	-0.8	-1.1	-0.9	0.6	0.0	1.6	-0.3	0.9	0.6
Medication: Paracetamol	0.4	0.6	2.7	-0.5	-0.0	-0.3	-1.6	-0.6	1.0	-0.9	0.4	-0.2
Medication: Lisinopril	2.6	3.3	5.1	2.0	2.1	1.7	-0.8	-1.4	-1.8	1.8	-2.3	-2.1
Medication: Atorvastatin	0.8	1.0	3.8	-1.7	-0.7	-0.4	-1.9	-0.2	-0.4	-0.6	0.9	-0.1
Illnesses of father: High blood pressure	1.6	1.9	3.7	-1.6	-1.8	-1.6	0.1	1.0	0.4	-1.9	1.2	1.6
Alcohol drinker status: Never	1.0	1.3	3.0	-1.2	-1.1	-1.6	-0.1	0.3	1.0	-0.8	1.1	1.7
Ever smoked	0.6	1.0	1.7	1.3	1.2	1.3	-0.2	-0.6	1.1	0.9	-1.1	-0.6
Basal metabolic rate	1.0	5.6	11.6	2.1	2.8	2.6	1.2	-0.6	-2.5	3.4	-2.6	-2.1
Leg fat percentage (left)	0.3	1.2	3.5	0.4	-1.1	-0.7	-1.9	-1.6	0.5	0.5	-1.1	-1.0
Arm fat-free mass (left)	1.0	5.0	8.9	2.0	2.9	2.6	1.2	-0.7	-2.2	3.0	-2.3	-2.2
Number of operations (self-reported)	0.1	0.2	0.6	0.1	-0.2	-0.1	0.2	-0.4	-0.8	0.3	-0.7	-0.0
Average weekly beer plus cider intake	0.4	0.5	2.0	0.1	0.9	0.3	1.4	-0.7	-0.5	1.0	-0.2	-0.1
Irritability	0.5	0.8	2.9	0.1	0.2	-0.1	-1.7	-0.4	1.0	-1.2	-0.9	-0.9
Risk taking	0.4	0.6	2.7	0.9	0.5	0.3	0.5	-0.1	-0.0	1.6	-1.2	-0.3
Ever had prostate specific antigen (PSA) test	2.2	2.5	5.3	-1.6	-1.5	-1.3	-0.2	2.3	1.8	-1.5	1.7	1.4
Fractured/broken bones in last 5 years	3.3	4.2	12.3	2.2	1.7	2.3	-0.1	-1.1	-3.5	2.5	-1.6	-1.6
Age started oral contraceptive pill	0.6	0.7	2.1	-0.3	-0.9	-0.5	0.3	1.5	1.1	-0.0	1.0	0.8
Diastolic blood pressure, automated reading	0.2	0.6	2.0	0.2	-0.3	0.0	-1.2	-0.9	-0.5	-0.3	-0.9	-1.4
Ever depressed for a whole week	1.4	1.7	3.8	1.4	1.9	1.8	0.1	0.2	-0.8	1.5	-1.2	-1.4
Unable to work because of sickness or disability	0.4	0.5	2.0	-0.0	-0.3	-0.7	-0.2	-1.4	-0.8	1.0	0.0	0.3
Commuting to job workplace: Cycle	0.5	0.6	1.3	-0.4	-0.9	-0.9	0.7	1.1	0.6	0.1	0.3	1.1
Myopia	0.8	1.1	3.5	-1.1	-1.9	-1.7	0.6	0.1	0.6	-0.3	0.2	1.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	4.2	1.1	0.9	0.7	0.2	-0.7	-0.4	2.0	-0.1	0.2
Cholesterol lowering medication	1.7	2.5	4.7	-2.0	-1.4	-1.7	1.9	1.3	0.8	-0.3	2.2	1.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.2	-1.1	-1.1	0.7	0.4	0.5	-0.1	0.3	0.4
Pain experienced in last month	1.5	2.6	7.5	1.2	1.7	1.6	1.8	-0.1	-2.3	2.7	-0.5	-0.3
Supplements: Calcium	1.6	1.7	7.4	1.2	1.3	1.1	1.2	-0.0	-2.7	1.3	-0.8	-0.0
Basal cell carcinoma (self-reported)	6.4	7.6	25.6	3.1	1.4	1.9	-0.4	-3.3	-2.2	1.5	-5.1	-3.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	0.4	0.9	0.4	1.0	-0.9	-1.1	-0.1	-1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	5.9	-1.9	-1.8	-1.6	0.6	2.4	1.3	-0.3	2.4	1.8
Heart disease (siblings)	4.9	6.0	10.4	-3.2	-2.7	-3.1	1.3	1.0	2.6	-2.7	1.9	2.5
Alcohol drinker status: Previous	0.3	0.4	1.2	-0.3	-0.9	-0.7	-0.7	-0.2	0.4	-1.1	0.3	0.3
Pack years of smoking	0.3	0.4	2.6	0.1	0.1	0.1	0.4	0.3	-0.5	1.6	0.7	0.2
Impedance of whole body	1.0	5.2	10.4	-2.3	-2.5	-2.6	1.0	1.9	1.7	-1.6	2.8	3.2
Leg fat mass (left)	0.4	1.4	3.7	1.1	0.0	0.3	-1.1	-1.4	-0.4	1.9	-1.6	-1.4
Arm predicted mass (left)	0.9	4.6	8.5	1.8	2.8	2.5	1.0	-0.6	-2.1	2.9	-2.3	-2.1