Hub : Genes

CASP8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.2440 0.0480 0.0e+00 0.304 NA 0.322 NA 0.318 3.4e-25 NA 6.5e-27 NA 1.7e-26
2 GTEx Adipose Visceral Omentum 0.1980 0.0620 5.2e-07 0.162 NA 0.094 NA 0.152 8.5e-09 NA 1.4e-05 NA 2.7e-08
3 GTEx Artery Aorta 0.1000 0.0460 2.4e-03 0.036 NA 0.062 NA 0.026 4.5e-03 NA 2.6e-04 NA 1.4e-02
4 GTEx Artery Tibial 0.0685 0.0361 4.8e-03 0.069 NA 0.044 NA 0.043 4.3e-06 NA 2.1e-04 NA 2.5e-04
5 GTEx Brain Cerebellar Hemisphere 0.5830 0.1030 7.6e-07 0.503 NA 0.418 NA 0.462 6.5e-15 NA 6.1e-12 NA 1.9e-13
6 GTEx Brain Cerebellum 0.4430 0.0830 1.7e-08 0.466 NA 0.456 NA 0.451 1.7e-15 NA 4.2e-15 NA 6.9e-15
7 GTEx Brain Frontal Cortex BA9 0.1305 0.0573 5.9e-03 0.237 NA 0.155 NA 0.209 6.0e-07 NA 6.6e-05 NA 3.1e-06
8 GTEx Breast Mammary Tissue 0.2890 0.0770 1.1e-07 0.182 NA 0.163 NA 0.195 1.1e-09 NA 9.9e-09 NA 2.7e-10
9 GTEx Breast Mammary Tissue (Male) 0.3235 0.1265 5.6e-03 0.004 NA 0.154 NA 0.024 2.5e-01 NA 2.0e-04 NA 9.4e-02
10 GTEx Breast Mammary Tissue (Female) 0.1966 0.0740 4.6e-04 0.241 NA 0.075 NA 0.220 8.5e-08 NA 2.9e-03 NA 3.5e-07
11 GTEx Cells Transformed fibroblasts 0.3030 0.0540 0.0e+00 0.352 NA 0.345 NA 0.351 2.1e-27 NA 1.0e-26 NA 2.6e-27
12 GTEx Colon Sigmoid 0.2210 0.0960 4.1e-03 -0.006 NA 0.043 NA 0.028 6.2e-01 NA 1.2e-02 NA 3.6e-02
13 GTEx Colon Transverse 0.2120 0.0630 3.4e-06 0.132 NA 0.144 NA 0.168 7.4e-07 NA 2.2e-07 NA 2.1e-08
14 GTEx Esophagus Mucosa 0.2230 0.0540 5.5e-10 0.173 NA 0.153 NA 0.195 1.1e-11 NA 2.1e-10 NA 4.5e-13
15 GTEx Lung 0.1828 0.0469 4.9e-08 0.179 NA 0.180 NA 0.175 1.1e-13 NA 9.6e-14 NA 2.1e-13
16 GTEx Muscle Skeletal 0.0830 0.0318 1.4e-04 0.070 NA 0.060 NA 0.066 2.0e-07 NA 1.4e-06 NA 4.3e-07
17 GTEx Nerve Tibial 0.1088 0.0405 3.1e-04 0.019 NA 0.059 NA 0.050 1.5e-02 NA 5.1e-05 NA 1.8e-04
18 GTEx Pancreas 0.1580 0.0580 1.2e-04 0.148 NA 0.107 NA 0.130 8.3e-07 NA 2.9e-05 NA 4.1e-06
19 GTEx Skin Not Sun Exposed Suprapubic 0.2630 0.0610 9.7e-10 0.245 NA 0.223 NA 0.219 1.2e-13 NA 1.8e-12 NA 3.3e-12
20 GTEx Skin Sun Exposed Lower leg 0.2390 0.0520 8.4e-13 0.225 NA 0.210 NA 0.194 1.7e-18 NA 2.9e-17 NA 6.1e-16
21 GTEx Spleen 0.4170 0.0950 5.7e-06 0.388 NA 0.319 NA 0.376 5.5e-11 NA 6.1e-09 NA 1.3e-10
22 GTEx Stomach 0.1820 0.0640 2.5e-04 0.133 NA 0.043 NA 0.108 6.3e-07 NA 4.0e-03 NA 7.3e-06
23 GTEx Uterus 0.3040 0.1140 2.5e-03 -0.014 NA 0.035 NA 0.005 8.6e-01 NA 6.8e-02 NA 2.5e-01
24 GTEx Whole Blood 0.0740 0.0290 5.0e-04 0.041 NA 0.020 NA 0.028 1.1e-04 NA 5.3e-03 NA 1.3e-03
25 METSIM Adipose 0.2006 0.0433 0.0e+00 0.200 0.159 0.183 0.189 0.190 3.6e-29 4.0e-23 1.2e-26 1.5e-27 1.2e-27
26 NTR Blood 0.0413 0.0125 4.0e-10 0.044 0.035 0.038 0.038 0.041 6.1e-14 2.0e-11 2.8e-12 3.1e-12 4.0e-13
27 ROSMAP Brain Pre-frontal Cortex 0.1972 0.0421 0.0e+00 0.203 0.166 0.191 0.199 0.193 1.7e-25 9.3e-21 6.4e-24 5.5e-25 3.2e-24
28 TCGA Cervical Squamous Cell Carcinoma 0.0900 0.0450 1.1e-03 0.092 0.068 0.054 NA 0.081 2.8e-05 3.0e-04 1.2e-03 NA 8.6e-05
29 TCGA Head and Neck Squamous Cell Carcinoma 0.0721 0.0296 2.0e-07 0.064 0.057 0.050 NA 0.062 1.1e-07 5.3e-07 2.7e-06 NA 1.6e-07
30 TCGA Lung Adenocarcinoma 0.0688 0.0304 1.8e-08 0.100 0.084 0.097 NA 0.096 1.0e-11 4.4e-10 2.3e-11 NA 2.4e-11
31 TCGA Lung Squamous Cell Carcinoma 0.0646 0.0287 2.4e-06 0.043 0.045 0.056 NA 0.050 1.2e-05 7.6e-06 5.1e-07 NA 2.1e-06
32 TCGA Soft Tissue Sarcoma 0.0880 0.0360 6.5e-06 0.053 0.077 0.088 NA 0.064 4.2e-04 2.3e-05 7.0e-06 NA 1.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Bipolar Disorder (2018) 1.1 1.7 3.3 -1.4 -1.3 -0.3 -1.4 1.3 1.5 1.3 -1.7 -0.4 -1.7 -1.4 0.1 -1.4 -1.6 -1.5 -1.4 -0.3 -1.8 -1.4 -1.2 -1.4 -1.3 0.2 -1.1 -1.4 -1.4 1.4 -1.4 -1.5 -1.4 -1.5 -0.6
Bipolar Disorder or Schizophrenia 1.1 2.7 11.2 -1.8 -1.4 -0.3 -1.1 1.0 1.1 0.9 -2.0 -3.4 -1.6 -1.9 -1.6 -1.7 -1.6 -1.6 -1.5 -2.0 -1.8 -1.6 -1.8 -1.9 -1.9 -1.2 -1.4 -1.9 -2.1 1.1 -1.1 -1.2 -1.3 -1.6 -1.5
Depressed Affect (Nagel 2018) 0.3 0.6 3.1 -0.5 -0.6 1.1 -0.2 0.8 0.7 0.8 -0.7 -1.8 -1.2 -0.5 1.3 -0.7 -0.0 -0.1 -0.1 0.5 -1.4 -0.4 -0.0 -0.1 -0.2 -0.7 -0.4 -0.3 -0.2 1.4 -0.6 -0.6 -0.7 -0.7 -0.8
Depression (Nagel 2018) 2.7 4.0 8.1 -1.9 -2.1 -0.3 -1.6 2.4 2.3 2.2 -2.1 -2.9 -2.1 -1.9 1.4 -2.1 -1.8 -1.9 -1.8 0.3 -2.5 -1.9 -1.7 -1.8 -2.0 -1.1 -2.1 -1.9 -1.8 2.4 -2.2 -2.2 -2.2 -2.0 -2.4
Intelligence (Savage-Jansen 2018) 0.1 0.3 2.5 -0.1 0.2 -0.1 -0.8 -0.3 -0.5 0.0 -0.2 1.5 -0.3 -0.2 -1.6 -0.1 0.3 0.1 -0.0 -0.4 0.2 0.1 -0.2 -0.1 -0.2 1.0 -0.3 -0.1 -0.0 -1.0 0.6 0.5 0.5 0.1 0.1
Neuroticism (Nagel 2018) 0.3 0.6 4.8 -0.6 -0.3 1.1 0.0 0.9 0.7 0.8 -0.4 -1.9 -1.0 -0.3 2.2 -0.6 0.1 -0.1 -0.4 -0.3 -1.0 -0.8 -0.2 -0.6 -0.6 -0.3 -0.4 -0.1 -0.0 1.0 -0.8 -0.8 -0.6 -0.4 -1.0
Schizophrenia (2018) 0.8 1.7 15.9 -1.2 -0.8 -0.1 -0.3 0.2 0.2 0.1 -1.3 -4.0 -0.6 -1.3 -2.2 -1.0 -0.7 -0.8 -0.8 -2.4 -0.8 -1.0 -1.3 -1.3 -1.4 -1.7 -0.8 -1.4 -1.5 0.3 -0.3 -0.4 -0.6 -0.8 -1.6
Schizophrenia vs Biploar Disorder 0.7 0.9 5.1 -1.2 -0.8 -0.6 -1.0 0.6 0.4 0.3 -0.9 -2.2 -0.4 -1.1 -0.3 -1.0 -0.7 -0.4 -0.8 -2.1 -0.4 -0.8 -1.2 -1.1 -1.0 -0.4 -0.9 -1.2 -1.2 0.5 -0.5 -0.5 -0.5 -0.7 -0.9
Worry (Nagel 2018) 1.2 2.6 7.8 1.7 1.6 2.0 1.6 -1.7 -1.6 -1.8 1.7 -0.5 2.0 1.6 2.8 1.6 1.8 1.8 1.5 0.7 1.6 1.1 1.8 1.3 1.5 0.8 1.6 1.4 1.3 -1.5 1.7 1.8 1.7 1.8 1.2
Alzheimer’s Disease (in mother) 0.9 1.1 6.2 1.0 0.9 2.5 0.4 -1.1 -1.1 -1.3 1.2 -0.4 1.4 1.1 0.9 1.1 1.1 1.3 1.1 0.6 1.1 0.7 0.7 0.7 0.5 0.6 1.2 0.8 0.8 -0.6 0.9 0.9 0.9 1.2 1.0
Alzheimer’s Disease (in father) 0.4 0.4 1.4 0.6 0.6 -0.4 1.2 -0.7 -0.8 -0.9 0.5 -0.3 1.1 0.5 0.5 0.6 -0.2 0.5 0.2 0.7 0.9 0.2 0.6 -0.0 0.3 0.7 0.3 0.2 0.1 -1.0 0.9 0.8 0.7 0.7 0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 3.1 0.9 0.8 1.1 0.5 -1.1 -1.0 -1.3 1.0 -0.3 1.8 0.8 0.5 1.0 0.4 0.9 0.4 0.5 1.3 0.2 0.4 0.0 0.1 0.3 0.7 0.3 0.3 -0.9 0.9 1.1 0.8 1.1 0.7
Crohns Disease (2017) 0.6 1.4 4.8 -1.1 -1.0 -1.5 -2.0 0.6 0.6 0.7 -1.1 -0.4 -0.8 -1.2 -0.8 -1.1 -0.7 -1.2 -1.3 -1.5 -0.9 -1.5 -1.5 -1.2 -1.1 -2.2 -1.0 -1.3 -1.3 0.6 -0.7 -0.8 -0.9 -1.1 -1.4
Irritable Bowel Disease (IBD) 0.2 0.5 4.1 -0.1 0.3 -0.7 -1.5 -0.7 -0.7 -0.5 -0.3 -0.6 -0.1 -0.3 -0.8 -0.1 0.6 0.1 -0.3 -1.6 -0.0 -0.9 -0.4 -0.3 0.1 -2.0 0.2 -0.4 -0.5 -0.4 0.6 0.5 0.3 -0.0 -0.7
Ulcerative Colitis (UC) 0.3 0.6 2.0 0.7 1.0 0.8 -0.4 -1.1 -1.1 -0.8 0.4 -0.1 0.2 0.5 -0.9 0.7 1.4 0.9 0.7 -0.4 0.5 0.0 0.6 0.6 1.0 -0.7 1.0 0.6 0.5 -0.9 1.1 1.1 0.9 0.7 0.1
Major Depression (MDD) 0.5 0.6 4.2 -0.3 -0.7 0.8 -0.6 1.2 1.1 1.0 -0.3 -0.2 -0.8 -0.3 1.0 -0.5 -0.3 -0.3 -0.1 1.2 -1.0 -0.1 -0.1 0.2 0.1 0.5 -0.5 -0.0 0.0 2.0 -1.0 -1.2 -1.0 -0.8 -0.4
Reaction Time 0.2 0.3 0.9 -0.5 -0.6 -0.7 0.1 0.3 0.4 0.2 -0.7 -1.0 -0.4 -0.7 -0.8 -0.6 -0.6 -0.7 -0.6 -0.2 -0.5 -0.6 -0.5 -0.6 -0.6 0.1 -0.6 -0.8 -0.9 0.4 -0.4 -0.4 -0.5 -0.6 -0.4
Verbal and Numeric Reasoning (VNR) 1.0 2.4 5.9 1.5 1.7 0.8 0.8 -1.9 -2.0 -1.8 1.4 1.6 1.5 1.4 -1.0 1.5 1.8 1.4 1.5 0.6 1.8 1.4 1.5 1.3 1.4 0.6 1.5 1.3 1.2 -2.4 1.9 2.0 1.9 1.7 1.6
Breast Cancer 20.4 49.1 69.1 7.9 7.7 5.1 5.7 -8.0 -8.0 -7.7 7.8 5.2 8.2 7.4 -0.4 7.8 7.8 7.2 7.1 3.0 8.1 6.6 7.6 6.6 6.7 0.6 6.8 6.9 6.7 -8.1 8.2 8.3 7.9 7.8 6.4
Ovarian Cancer 2.2 2.9 4.7 2.0 1.8 1.5 0.8 -1.9 -1.9 -1.8 1.7 1.5 1.9 1.6 1.4 1.8 1.7 1.7 1.8 1.4 1.8 1.2 2.0 1.7 1.8 0.3 1.4 1.6 1.6 -2.0 2.2 2.2 1.9 1.8 1.1
Prostate Cancer 5.2 7.3 11.1 2.9 2.9 1.7 2.5 -3.0 -2.9 -3.1 3.0 1.8 2.7 3.0 -0.8 3.0 2.7 3.1 3.0 1.1 2.9 2.6 2.8 2.6 2.7 1.1 3.3 3.0 2.9 -2.4 2.9 2.9 3.0 3.0 2.9
Age at First Birth 2.4 3.5 5.6 -2.0 -2.2 -2.4 -1.5 2.0 1.9 2.1 -2.0 0.1 -1.9 -2.1 0.6 -2.1 -2.0 -1.8 -1.9 -1.2 -1.7 -1.9 -2.0 -1.8 -1.8 -1.2 -2.0 -2.0 -1.9 1.8 -2.0 -1.9 -2.1 -2.1 -2.2
Bipolar Disorder (2011) 0.7 0.7 2.7 0.8 0.7 0.2 1.1 -0.5 -0.3 -0.4 0.5 1.5 0.2 1.0 0.3 0.8 0.4 0.4 0.5 1.6 0.5 1.2 1.2 0.7 0.7 0.9 0.7 0.9 0.9 -0.4 0.4 0.5 0.6 0.7 1.4
Body Mass Index (BMI) (2010) 0.3 0.4 2.9 0.6 0.7 1.7 0.8 -0.6 -0.6 -0.6 0.5 -0.5 0.7 0.5 -0.0 0.7 0.8 0.8 0.7 -0.1 0.6 0.6 0.6 0.5 0.7 0.1 0.5 0.4 0.4 -0.5 0.7 0.7 0.7 0.6 0.6
Coronary Artery Disease (CAD) 0.3 0.3 2.8 -0.4 -0.3 -0.4 -1.3 0.0 0.1 -0.1 -0.2 -0.8 -0.3 -0.3 -1.2 -0.3 0.1 -0.3 -0.1 -1.5 -0.6 -0.5 -0.4 -0.3 -0.4 -1.7 -0.1 -0.2 -0.2 0.3 0.3 -0.3 -0.1 -0.3 -0.4
Crohns Disease (2012) 0.1 0.2 0.7 0.3 0.4 -0.0 -0.8 -0.8 -0.8 -0.7 0.3 0.5 0.3 0.3 -0.5 0.2 0.7 0.2 0.3 -0.8 0.3 -0.0 0.1 0.3 0.3 -0.5 0.5 0.2 0.2 -0.3 0.7 0.5 0.5 0.3 0.3
Mean Putamen Volume 3.5 4.0 7.8 2.1 1.9 2.4 2.8 -1.7 -1.7 -1.7 2.0 2.5 1.6 2.0 -1.1 2.0 2.2 2.0 2.3 2.3 1.9 2.3 2.2 2.2 2.3 1.1 1.9 2.1 2.0 -1.9 1.7 1.7 1.8 1.8 2.0
Fasting Glucose 0.1 0.2 0.9 -0.3 -0.5 0.3 -0.3 0.2 0.3 -0.0 -0.3 1.0 0.1 -0.4 -0.8 -0.3 -0.8 -0.4 0.1 0.1 -0.2 -0.1 -0.3 -0.1 0.1 0.5 -0.1 -0.5 -0.5 0.4 -0.4 -0.4 -0.4 -0.4 0.2
HbA1C 1.0 1.1 2.7 1.3 0.9 -0.3 1.4 -1.5 -1.3 -1.4 0.9 0.8 1.3 1.0 -0.5 1.2 0.5 1.2 0.7 0.2 1.4 0.9 1.2 0.7 0.6 0.3 1.1 0.7 0.6 -1.2 1.6 1.5 1.2 1.2 0.9
HDL Cholesterol 0.3 0.6 2.1 -0.9 -0.5 -1.3 -1.3 0.5 0.2 0.5 -1.0 -0.5 -1.1 -0.8 -1.5 -0.9 -0.3 -0.6 -0.5 -1.1 -0.8 -0.5 -0.7 -0.3 -0.3 -1.4 -0.5 -0.7 -0.6 0.1 -0.1 -0.4 -0.2 -0.6 -0.6
LDL Cholesterol 0.9 1.4 9.3 1.0 1.2 1.4 1.4 -1.0 -0.9 -1.0 0.9 0.5 0.7 1.4 -0.3 1.2 0.5 1.1 0.8 0.7 1.3 1.1 1.2 0.7 1.1 3.0 1.5 1.0 1.0 -0.8 0.8 1.0 1.0 1.1 2.2
Lupus 1.3 2.0 5.4 -1.4 -1.5 -0.5 -1.3 0.8 0.8 0.5 -1.5 -1.0 -0.5 -1.7 0.3 -1.6 -1.3 -1.6 -1.7 -1.1 -0.9 -2.3 -1.5 -2.1 -2.1 -0.6 -1.4 -1.9 -2.1 0.6 -0.7 -0.7 -1.2 -1.4 -2.3
Neuroticism (2016) 0.4 0.6 2.3 -0.8 -0.8 0.2 -0.5 1.1 1.0 0.9 -0.6 -0.9 -1.1 -0.5 0.2 -0.8 -0.6 -0.2 -0.1 0.1 -1.0 -0.4 -0.6 -0.1 -0.1 1.3 -0.5 -0.3 -0.1 1.5 -1.1 -1.2 -0.8 -0.8 -0.4
Primary Biliary Cirrhosis 0.3 0.4 1.4 -0.3 -0.7 0.1 0.8 0.9 1.1 0.9 -0.2 -1.2 -0.0 -0.3 0.7 -0.3 -0.9 -0.3 -0.3 0.7 -0.3 -0.4 -0.2 -0.2 -0.3 0.5 -0.7 -0.2 -0.2 0.9 -1.0 -0.8 -1.0 -0.6 -0.8
Rheumatoid Arthritis 3.6 4.9 12.4 -2.1 -1.6 -2.3 -3.2 0.5 0.4 0.6 -2.5 -1.3 -0.8 -2.6 -1.1 -2.1 -1.6 -2.5 -2.9 -3.2 -1.4 -3.0 -2.5 -3.3 -3.2 -3.2 -2.1 -3.3 -3.5 0.1 -0.3 -0.4 -1.0 -1.7 -2.2
Schizophrenia (2014) 1.8 4.0 14.1 -2.3 -1.8 -0.7 -0.8 1.5 1.5 1.4 -2.4 -3.8 -1.9 -2.2 -2.2 -2.0 -2.0 -1.9 -1.8 -2.5 -2.0 -1.9 -2.2 -2.2 -2.2 -1.1 -2.1 -2.4 -2.5 1.6 -1.6 -1.7 -1.8 -2.0 -1.8
Triglycerides 2.4 3.9 7.2 1.9 2.2 2.5 1.9 -2.3 -2.3 -2.3 2.1 1.2 2.4 2.0 0.6 2.2 1.8 2.4 1.5 0.1 2.7 1.6 1.7 0.9 1.0 2.1 1.9 1.6 1.6 -2.1 2.2 2.3 2.2 2.2 2.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 1.0 0.2 0.2 -0.2 -0.0 -0.2 -0.2 -0.2 0.3 -0.3 0.0 0.3 -0.7 0.2 0.5 0.1 0.3 0.1 0.0 0.4 0.4 0.4 0.5 -1.0 0.5 0.5 0.5 -0.0 0.3 0.2 0.2 0.2 -0.2
Ulcerative Colitis 0.2 0.2 1.9 -0.1 0.3 -0.4 -0.5 -0.6 -0.6 -0.3 -0.4 -0.9 -0.3 -0.3 -0.4 -0.1 0.5 0.2 -0.2 -1.4 0.1 -0.9 -0.1 -0.3 0.3 -0.5 0.3 -0.3 -0.5 -0.4 0.6 0.5 0.3 -0.1 -0.4
Blood Eosinophil Count 0.7 5.6 11.8 2.7 2.1 3.4 2.6 -1.9 -1.8 -1.7 2.4 1.6 1.5 2.4 2.2 2.3 2.7 3.1 3.1 2.9 1.6 2.8 3.1 3.2 3.0 0.9 2.3 2.8 2.7 -0.9 1.9 1.9 1.8 1.8 1.4
Blood Platelet Count 8.6 99.4 136.9 11.2 10.6 5.8 11.5 -9.1 -9.0 -8.9 10.7 5.8 9.2 11.4 5.2 11.0 9.2 10.6 10.5 8.6 10.3 11.3 11.7 10.9 10.9 9.6 10.6 11.2 10.9 -8.0 9.5 9.6 10.1 10.7 11.1
Blood Red Count 1.5 14.2 21.9 -4.3 -4.3 -2.8 -3.5 3.8 3.6 3.8 -3.8 -0.0 -3.3 -4.2 -2.2 -4.2 -3.6 -4.1 -4.0 -3.1 -3.5 -4.2 -4.7 -3.9 -4.0 -3.4 -4.5 -4.1 -4.0 2.8 -3.9 -3.9 -4.1 -4.2 -4.0
Blood White Count 2.9 21.6 31.2 4.9 5.3 2.9 3.2 -5.3 -5.4 -5.6 5.3 0.3 5.5 5.1 -0.3 5.4 5.1 5.6 4.9 0.4 5.4 4.8 4.4 4.3 4.2 1.8 5.2 4.7 4.6 -4.4 5.1 5.2 5.3 5.4 5.1
Heel T-Score 0.1 0.7 5.7 -0.2 -0.3 1.7 0.9 0.3 0.5 0.1 0.2 -2.4 0.5 -0.1 2.3 0.0 -0.5 1.0 0.3 -0.7 0.2 -0.3 -0.2 -0.1 -0.1 0.8 -0.2 -0.0 0.0 1.4 -0.5 -0.5 -0.4 -0.1 -0.3
BMI 0.1 0.6 2.0 -0.7 -0.6 0.7 -0.2 1.2 1.1 1.2 -0.8 0.9 -1.4 -0.6 -0.4 -0.7 -0.3 -0.6 -0.2 0.1 -1.4 -0.4 -0.4 0.0 -0.2 -1.2 -0.8 -0.4 -0.2 0.9 -1.0 -1.1 -0.9 -1.1 -0.3
Height 0.2 3.7 11.3 -1.8 -0.9 -3.3 -2.4 0.2 -0.1 0.5 -1.9 -3.4 -0.8 -1.8 1.1 -1.6 -1.5 -1.7 -2.5 -3.2 -0.8 -1.9 -1.9 -2.8 -2.9 -3.3 -1.2 -2.3 -2.5 -0.5 0.3 0.2 -0.1 -0.5 -2.4
Waist Hip Ratio (WHR) 1.6 7.2 10.0 -2.9 -2.9 -2.3 -2.6 2.7 2.8 2.6 -3.0 -2.9 -2.6 -2.9 -0.2 -2.9 -3.2 -2.7 -2.9 -1.9 -2.8 -2.8 -2.7 -2.9 -2.8 -1.4 -2.7 -2.9 -2.8 2.9 -2.8 -2.7 -2.8 -2.7 -2.6
Systolic Blood Pressure 0.1 0.4 5.0 0.0 -0.1 -2.2 0.2 0.1 0.0 0.2 0.1 1.1 0.6 0.0 -1.6 0.1 -0.7 -0.6 -0.4 -0.0 0.5 -0.1 -0.2 -0.2 -0.1 -0.7 -0.6 -0.2 -0.2 -0.3 0.0 0.0 0.0 0.1 0.2
Smoking Status 0.4 0.9 4.5 -0.7 -0.7 0.5 -0.7 1.2 1.1 1.1 -1.0 -2.1 -1.5 -0.7 0.6 -0.8 -0.9 -0.6 -0.2 0.6 -1.4 -0.4 -0.3 -0.2 -0.2 1.2 -0.5 -0.4 -0.3 2.0 -1.1 -1.1 -0.9 -0.9 -0.5
Allergy or Eczema 1.1 2.8 5.9 -1.6 -1.9 -1.9 -0.9 1.5 1.6 1.8 -1.9 -0.4 -1.3 -1.9 0.9 -1.9 -1.8 -1.7 -2.0 -0.2 -1.7 -2.1 -1.4 -1.8 -1.6 -1.4 -2.2 -2.0 -2.1 1.2 -1.4 -1.3 -1.7 -1.7 -2.4
Cardiovascular Disease 0.4 1.4 3.8 1.2 1.1 0.2 1.9 -1.2 -1.3 -1.4 1.4 0.5 2.0 1.0 1.1 1.3 0.6 1.1 1.0 0.4 1.9 0.7 1.1 0.8 1.0 1.3 0.7 0.9 0.7 -1.3 1.3 1.4 1.2 1.2 1.3
Hypothyroidism (self reported) 0.3 0.8 5.3 -0.3 -0.0 -0.7 -1.3 -0.6 -0.7 -0.9 -0.6 -1.0 0.5 -0.7 -1.7 -0.2 0.0 -0.5 -0.7 -0.9 -0.0 -0.9 -0.6 -1.2 -0.8 -2.3 -0.3 -1.0 -1.3 -0.5 0.7 0.7 0.1 -0.2 -1.5
Respiratory disease 1.2 2.7 4.1 1.6 1.9 -0.1 1.1 -1.6 -2.0 -1.4 1.8 1.4 1.5 1.9 -1.5 1.7 1.9 1.9 1.6 0.2 1.9 2.0 1.6 1.8 1.6 0.2 1.6 1.8 1.8 -1.7 1.8 1.9 1.9 1.8 1.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.2 -0.2 -0.1 -0.7 -0.1 0.4 0.3 0.6 -0.3 -1.0 -0.3 -0.3 1.1 -0.1 -0.1 -0.4 -0.3 -0.2 -0.7 -0.4 -0.3 -0.1 0.0 -0.7 -0.6 -0.2 -0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.4
Lung FEV1/FVC ratio 1.0 4.9 8.0 -2.2 -2.5 -0.9 -1.0 2.2 2.6 2.0 -2.2 -2.3 -1.9 -2.3 0.5 -2.2 -2.8 -2.7 -2.0 0.0 -2.6 -2.4 -1.9 -2.1 -2.1 -1.4 -2.2 -2.2 -2.3 2.7 -2.6 -2.5 -2.8 -2.5 -2.8
Lung FVC 1.5 7.5 11.4 -3.2 -3.0 -1.0 -1.3 2.9 2.9 2.8 -3.0 -3.0 -2.3 -3.0 1.5 -3.0 -3.4 -2.4 -2.9 -2.3 -2.6 -2.8 -3.1 -3.1 -3.1 0.8 -3.2 -3.2 -3.2 2.5 -3.0 -3.0 -2.9 -2.8 -1.9
Neuroticism 0.2 0.5 3.8 0.4 0.5 1.6 0.8 -0.3 -0.3 -0.3 0.3 -1.9 0.0 0.5 1.1 0.4 0.7 0.9 0.9 0.1 -0.1 0.4 0.8 0.6 0.6 0.6 0.6 0.5 0.6 -0.1 0.4 0.3 0.5 0.5 0.5
Chronotype (morning person) 1.2 2.9 6.9 1.7 2.1 1.0 1.4 -2.5 -2.4 -2.6 1.5 -1.6 2.2 1.6 0.0 1.9 1.5 1.7 1.4 -0.4 1.8 1.2 1.5 0.9 0.6 -0.4 1.9 1.2 0.9 -2.0 2.3 2.4 2.1 2.0 1.6
Hair Pigment 0.2 5.1 9.1 -2.4 -2.4 -0.3 -1.6 2.5 2.6 2.8 -2.7 -1.2 -2.9 -2.4 0.2 -2.5 -2.3 -2.6 -2.2 -0.3 -3.0 -2.4 -2.1 -2.0 -2.3 -0.4 -2.5 -2.3 -2.2 2.4 -2.5 -2.5 -2.5 -2.6 -2.2
Tanning 0.0 0.2 1.3 -0.5 -0.5 -0.1 -1.2 0.1 0.3 0.0 -0.4 -0.1 -0.5 -0.6 -0.2 -0.5 -0.3 -0.1 -0.3 -0.8 -0.5 -0.4 -0.7 -0.4 -0.4 -0.7 -0.3 -0.3 -0.3 0.9 -0.5 -0.5 -0.5 -0.6 -0.7
Hand grip strength (left) 1.1 2.8 5.5 -1.7 -1.8 -0.5 -1.1 1.5 1.5 1.7 -2.0 -1.0 -1.3 -2.0 -0.1 -1.8 -1.6 -1.6 -2.1 -0.6 -1.6 -2.1 -1.9 -2.3 -2.1 -0.7 -2.1 -2.3 -2.3 1.1 -1.4 -1.5 -1.7 -1.7 -2.1
Number of treatments/medications taken 1.2 2.2 3.9 1.6 1.6 1.2 1.4 -1.4 -1.5 -1.5 1.8 1.0 1.5 1.7 0.2 1.7 2.0 1.7 1.8 0.5 1.5 1.6 1.6 1.8 2.0 0.0 1.5 1.8 1.8 -1.2 1.5 1.5 1.5 1.5 1.1
Average weekly spirits intake 0.4 0.5 1.8 0.8 0.4 0.3 0.3 -0.3 -0.2 -0.4 1.1 0.7 1.1 0.8 0.3 0.7 0.5 0.8 0.8 1.3 0.8 1.0 0.7 1.0 0.8 0.3 0.4 0.9 0.9 -0.3 0.3 0.4 0.4 0.7 -0.1
Sensitivity / hurt feelings 0.3 0.5 4.1 0.4 0.4 0.9 1.2 -0.0 -0.2 0.0 0.5 -0.1 0.1 0.6 1.9 0.3 0.6 0.9 0.9 0.3 0.4 0.7 0.6 0.9 0.7 2.0 0.4 0.8 0.8 0.2 0.3 0.2 0.4 0.4 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 5.1 -0.4 -0.6 -0.2 -0.2 0.2 0.1 0.1 -0.3 -2.3 0.4 -0.6 -0.0 -0.4 0.1 -0.4 -0.5 -0.6 -0.2 -1.1 -0.5 -0.9 -0.7 -2.0 -0.7 -0.8 -0.9 -0.3 -0.1 -0.1 -0.4 -0.2 -2.1
Hearing difficulty/problems: Yes 0.8 1.2 4.0 1.1 1.1 1.5 0.4 -1.0 -1.2 -0.8 0.8 1.5 0.6 1.0 -2.0 1.0 1.2 1.0 0.9 0.7 0.9 0.8 1.1 0.8 1.1 1.0 0.8 0.8 0.8 -1.2 1.3 1.2 1.1 0.9 1.4
Relative age of first facial hair 0.3 0.6 3.4 0.5 0.1 0.8 1.6 0.4 0.5 0.2 0.6 -1.8 0.1 0.7 1.4 0.4 0.2 0.6 0.9 1.6 0.2 1.1 0.7 0.9 0.9 0.7 0.7 0.9 0.9 0.7 -0.4 -0.4 -0.2 0.3 -0.4
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.6 -1.5 -1.4 -1.9 -1.1 1.5 1.4 1.5 -1.6 -1.1 -1.5 -1.6 -0.4 -1.4 -1.8 -1.6 -1.4 -0.4 -1.7 -1.5 -1.4 -1.4 -1.3 -1.0 -1.5 -1.5 -1.6 1.5 -1.5 -1.4 -1.6 -1.6 -1.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.5 -0.0 -0.3 -0.0 0.1 0.4 0.3 0.5 0.3 -0.0 0.1 0.3 -0.6 -0.0 -0.2 -0.1 0.0 0.0 0.0 0.1 -0.0 0.2 -0.0 -0.3 0.1 0.3 0.4 0.7 -0.4 -0.4 -0.2 0.1 0.0
Ever had hysterectomy (womb removed) 0.5 0.6 2.4 -0.7 -0.9 -0.9 0.5 0.4 0.5 0.2 -0.3 -0.5 0.1 -0.8 1.5 -0.7 -0.7 -0.4 -0.6 -1.0 -0.1 -0.8 -0.9 -0.8 -0.9 -1.0 -0.6 -0.7 -0.8 0.9 -0.6 -0.6 -0.8 -0.6 -1.3
Systolic blood pressure, automated reading 0.2 0.6 3.4 0.7 0.5 -0.2 1.9 -0.1 -0.1 0.0 0.7 1.3 0.3 0.9 0.0 0.6 0.1 0.6 0.9 0.6 0.5 1.1 1.0 1.3 1.3 0.6 0.3 1.0 1.1 -0.3 0.2 0.1 0.4 0.5 1.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.8 -0.4 -0.8 -1.1 0.9 1.0 1.0 0.7 -0.4 -1.0 -0.2 -0.4 1.7 -0.5 -1.0 -0.1 -0.3 0.6 -0.4 -0.2 -0.3 -0.1 -0.2 1.1 -0.7 -0.4 -0.4 0.9 -1.0 -0.9 -0.8 -0.5 -0.3
Angina 1.6 2.1 7.5 1.9 1.5 -0.2 1.5 -1.4 -1.2 -1.3 1.6 1.7 1.5 1.7 -0.0 1.8 1.1 1.0 1.3 2.7 1.3 1.3 1.9 1.5 1.2 1.2 1.6 1.5 1.4 -1.1 1.3 1.4 1.3 1.6 1.4
Medication for hormone replacement therapy 1.0 1.2 6.8 -0.8 -0.6 -2.3 -1.6 -0.0 -0.1 -0.0 -0.6 -2.6 -0.2 -0.9 -0.5 -0.8 -0.5 -0.6 -0.8 -2.1 -0.3 -1.0 -1.1 -1.1 -1.0 -2.2 -0.6 -0.9 -0.9 0.1 0.0 -0.0 -0.1 -0.2 -1.6
Vitamin and mineral supplements 0.9 1.2 3.4 1.1 1.0 1.3 1.9 -0.8 -0.8 -0.9 0.8 0.8 0.3 1.1 -1.2 1.0 0.8 0.9 1.1 1.7 0.4 1.2 1.3 1.2 1.0 1.0 1.2 1.2 1.2 -0.6 0.7 0.7 0.8 0.8 1.6
Supplements: Zinc 0.2 0.2 2.3 -0.0 -0.1 -0.4 -1.1 -0.2 -0.1 -0.3 -0.2 -0.5 0.2 -0.2 -1.5 -0.2 0.2 -0.4 -0.4 0.2 -0.4 -0.2 -0.0 -0.2 -0.4 -1.5 -0.1 -0.3 -0.4 0.3 0.2 0.2 0.0 -0.0 -0.4
Medication: Co-codamol 1.2 1.4 2.9 -1.4 -1.0 -0.7 -1.6 1.0 0.7 0.9 -1.5 -0.9 -1.6 -1.3 -1.1 -1.4 -1.0 -1.4 -1.1 -1.4 -1.6 -0.7 -1.2 -1.2 -1.2 -1.7 -0.9 -1.3 -1.2 0.8 -0.8 -0.9 -0.9 -1.2 -0.9
Medication: Metformin 0.2 0.2 0.8 -0.2 -0.1 -0.9 0.2 0.6 0.5 0.8 -0.3 -0.2 -0.8 -0.1 0.8 -0.2 -0.3 -0.3 -0.2 0.5 -0.7 0.3 0.0 0.2 -0.0 0.8 -0.4 0.1 0.1 0.8 -0.4 -0.4 -0.3 -0.4 0.2
Diabetes (father) 0.2 0.3 2.7 0.4 0.6 -0.0 -0.3 -0.4 -0.4 -0.4 0.3 0.2 0.3 0.5 -1.6 0.4 0.3 0.0 0.4 0.4 0.3 0.6 0.5 0.5 0.3 0.6 0.6 0.3 0.4 -0.7 0.6 0.4 0.6 0.6 0.8
Diabetes (mother) 0.0 0.1 0.4 -0.1 -0.2 -0.1 0.1 0.3 0.2 0.2 0.0 0.6 0.1 -0.1 0.1 -0.1 -0.3 -0.5 -0.2 0.5 -0.2 -0.1 -0.2 -0.2 -0.0 0.3 -0.3 -0.1 -0.1 0.2 -0.2 -0.2 -0.2 -0.2 0.0
Severe depression (siblings) 2.0 2.3 4.2 -1.8 -1.6 -0.7 -1.2 1.7 1.5 1.8 -1.5 -1.0 -1.3 -1.7 0.5 -1.6 -1.6 -1.2 -1.6 -2.0 -1.2 -2.0 -1.9 -1.9 -1.5 -0.6 -1.9 -1.7 -1.5 1.0 -1.6 -1.5 -1.5 -1.5 -1.4
Pack years adult smoking proportion 0.1 0.1 0.9 0.1 0.3 0.4 -0.3 -0.5 -0.5 -0.5 -0.1 -0.2 -0.1 0.0 -0.5 0.1 0.4 -0.3 0.0 -0.3 -0.2 0.3 0.2 -0.0 -0.1 -0.9 0.5 -0.1 -0.2 -0.3 0.6 0.5 0.4 0.1 0.1
Impedance of leg (right) 0.2 1.0 4.3 0.8 1.1 0.8 0.4 -0.5 -0.7 -0.1 1.0 -0.3 0.3 1.2 1.1 0.9 0.9 1.4 0.9 0.2 1.0 1.5 0.9 1.0 1.0 2.1 0.8 1.1 1.3 -0.4 0.7 0.8 1.1 1.1 1.8
Leg fat-free mass (left) 1.0 5.3 14.4 -2.4 -2.3 -2.2 -1.8 1.9 1.9 1.6 -2.5 -1.4 -1.8 -2.6 -0.7 -2.4 -2.0 -2.6 -2.5 -2.1 -2.2 -2.7 -2.6 -2.6 -2.5 -3.8 -2.3 -2.7 -2.8 1.2 -1.8 -1.9 -2.2 -2.3 -3.2
Trunk fat percentage 0.1 0.3 1.3 0.2 0.1 0.7 0.7 0.4 0.4 0.5 0.3 1.1 -0.5 0.4 0.5 0.2 0.6 0.5 0.7 0.1 -0.4 0.6 0.4 1.0 1.1 -0.6 0.0 0.7 0.9 0.4 -0.4 -0.4 -0.1 -0.2 0.6
Hand grip strength (right) 0.5 1.3 3.4 -1.2 -0.9 0.0 -1.3 0.5 0.6 0.6 -1.5 -1.2 -0.8 -1.4 -0.5 -1.1 -0.8 -1.1 -1.6 -1.5 -1.0 -1.3 -1.4 -1.8 -1.6 -1.2 -1.2 -1.8 -1.9 -0.1 -0.5 -0.7 -0.8 -0.9 -1.0
Townsend deprivation index at recruitment 0.4 0.5 1.6 -0.7 -0.9 -1.1 0.2 0.8 0.9 0.6 -0.6 -0.2 -0.5 -0.7 -0.6 -0.8 -0.7 -0.7 -0.6 -0.4 -0.5 -0.7 -0.7 -0.5 -0.3 -0.1 -0.8 -0.6 -0.7 0.9 -0.8 -0.8 -0.9 -0.8 -1.3
Current tobacco smoking 1.1 1.9 12.0 -1.3 -1.2 -1.0 -1.1 1.5 1.6 1.4 -1.3 -3.5 -1.6 -1.1 1.4 -1.2 -1.3 -0.8 -0.8 -0.6 -1.6 -0.7 -0.9 -0.7 -0.7 0.8 -1.2 -0.8 -0.7 2.1 -1.5 -1.6 -1.3 -1.1 -1.3
Average weekly fortified wine intake 0.7 0.8 2.2 0.7 0.7 0.2 1.4 -0.7 -0.7 -0.4 0.9 0.9 0.8 0.8 1.5 0.7 0.7 1.4 1.0 -0.4 1.1 0.9 1.0 1.0 1.1 1.0 0.5 1.0 1.0 -0.9 0.8 0.8 0.9 0.8 0.6
Maternal smoking around birth 0.4 0.6 2.2 -0.8 -0.8 0.1 0.4 0.8 0.9 0.5 -1.0 -1.5 -1.0 -0.7 -0.6 -0.8 -0.9 -0.4 -0.6 0.0 -0.8 -0.9 -0.4 -0.7 -0.3 0.7 -0.6 -0.7 -0.8 1.0 -0.9 -0.9 -0.9 -0.9 -0.6
Fed-up feelings 0.2 0.3 1.0 0.4 0.5 0.8 0.3 -0.4 -0.5 -0.3 0.1 -0.6 -0.4 0.4 -1.0 0.3 1.0 0.5 0.7 0.5 -0.1 0.5 0.7 0.7 0.9 0.0 0.4 0.5 0.5 -0.3 0.6 0.5 0.5 0.3 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 9.8 -2.0 -2.2 -1.0 -1.2 2.2 2.1 1.9 -2.0 -3.1 -1.6 -2.1 0.3 -2.0 -1.8 -1.9 -2.1 -0.5 -2.0 -2.3 -2.0 -2.3 -2.2 -1.6 -2.2 -2.2 -2.2 1.9 -2.1 -2.0 -2.2 -1.9 -2.6
Relative age voice broke 0.3 0.5 2.1 0.2 -0.2 -0.1 1.3 0.9 0.8 0.8 0.4 0.4 -0.3 0.6 0.0 0.1 -0.1 0.4 0.5 1.5 -0.1 1.0 0.5 1.0 1.1 0.4 0.1 0.8 1.0 0.8 -0.8 -0.8 -0.4 0.0 0.4
Taking other prescription medications 0.2 0.3 5.7 -0.1 -0.0 0.2 -1.1 0.2 0.1 0.3 0.0 -0.1 -0.4 -0.0 -2.4 -0.1 0.5 -0.0 -0.0 -0.7 -0.4 0.4 -0.1 0.2 0.1 -1.3 -0.2 0.1 0.2 0.7 -0.1 -0.1 -0.1 -0.2 -0.2
Age when periods started (menarche) 0.5 1.1 4.5 0.1 0.3 -1.9 -1.4 -1.5 -1.3 -1.7 0.2 -0.3 1.7 -0.3 0.3 0.2 -0.0 -0.3 -0.4 -2.1 1.2 -0.9 -0.4 -0.9 -0.5 -1.8 0.5 -0.7 -1.0 -1.2 1.2 1.2 0.8 0.7 -0.9
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 3.7 -1.8 -1.7 -1.0 -0.9 1.8 1.7 1.6 -1.6 -1.2 -1.7 -1.7 -0.2 -1.8 -1.8 -1.3 -1.3 -0.7 -1.7 -1.5 -1.8 -1.4 -1.5 -0.2 -1.6 -1.4 -1.4 1.8 -1.8 -1.9 -1.7 -1.7 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 8.9 0.3 -0.0 3.0 -0.1 0.3 0.3 0.1 0.8 -0.0 0.6 0.5 0.2 0.4 0.7 0.5 0.4 1.1 0.1 0.1 0.1 0.3 0.1 0.3 -0.0 0.5 0.7 0.6 -0.4 -0.3 -0.2 0.1 0.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 2.0 0.1 -0.5 -0.1 0.3 0.3 0.5 0.0 0.0 -0.2 -0.1 -0.1 1.1 -0.2 -0.2 -0.1 0.2 1.4 -0.3 -0.2 0.3 0.4 0.6 -0.3 0.0 0.1 0.0 0.9 -0.6 -0.5 -0.7 -0.4 -0.8
Qualifications: CSEs or equivalent 3.6 4.8 8.0 -2.4 -2.6 -1.3 -1.2 2.6 2.6 2.4 -2.2 -0.3 -2.5 -2.4 0.2 -2.4 -2.3 -2.2 -1.9 -0.5 -2.6 -2.3 -2.3 -1.8 -1.7 0.3 -2.4 -2.0 -2.0 2.8 -2.6 -2.7 -2.7 -2.8 -2.5
Serious illness, injury or assault to yourself 3.3 4.0 8.7 -2.2 -1.8 -1.2 -2.9 2.1 1.8 2.2 -2.3 -2.5 -2.3 -2.0 -1.2 -2.1 -1.5 -2.2 -2.3 -1.1 -2.4 -2.1 -2.2 -2.1 -1.9 -1.8 -2.2 -2.1 -2.0 1.6 -1.7 -1.8 -1.8 -2.0 -1.5
High blood pressure 0.1 0.1 0.6 -0.2 -0.4 -0.5 0.6 0.4 0.4 0.2 -0.1 0.3 0.3 -0.4 0.5 -0.2 -0.8 -0.3 -0.1 0.0 0.1 -0.3 -0.2 -0.1 0.0 0.4 -0.7 -0.3 -0.4 0.5 -0.4 -0.3 -0.5 -0.4 -0.2
Hayfever, allergic rhinitis or eczema 2.6 5.8 10.7 -2.5 -2.7 -2.2 -1.9 2.2 2.4 2.3 -2.6 -1.3 -2.0 -2.8 0.6 -2.7 -2.4 -2.5 -2.6 -0.8 -2.6 -2.8 -2.3 -2.5 -2.4 -2.2 -3.0 -2.8 -2.7 2.0 -2.3 -2.2 -2.5 -2.5 -3.3
Multivitamins +/- minerals 0.4 0.5 3.7 0.7 0.7 0.7 -0.0 -0.5 -0.5 -0.3 0.9 0.7 1.1 0.7 1.9 0.8 0.6 0.4 0.5 0.3 1.0 0.7 0.6 0.4 0.5 0.4 0.4 0.4 0.4 -0.5 0.6 0.6 0.7 0.8 0.5
Stomach or abdominal pain in last month 0.9 1.1 4.0 1.0 0.9 0.9 0.8 -0.6 -0.6 -0.4 1.0 1.1 0.2 1.1 -0.4 0.9 1.3 1.6 1.3 0.5 0.6 1.6 1.2 1.6 2.0 1.1 1.0 1.4 1.5 -0.2 0.6 0.5 0.7 0.7 1.3
Supplements: Glucosamine 1.4 1.8 4.2 1.3 1.5 -0.3 0.4 -1.9 -2.0 -1.8 1.2 1.4 1.5 1.2 0.8 1.2 1.3 1.0 0.9 -0.5 1.7 0.8 1.1 0.7 0.7 -0.8 1.4 1.0 0.8 -2.1 2.0 2.0 1.8 1.6 0.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 -1.0 -1.2 -1.4 -0.8 1.4 1.5 1.4 -1.0 0.8 -1.3 -1.0 -1.3 -1.1 -1.2 -1.1 -0.7 0.3 -1.3 -0.7 -0.9 -0.4 -0.4 -1.1 -1.1 -0.8 -0.6 1.2 -1.5 -1.5 -1.4 -1.3 -1.0
Medication: Atenolol 0.3 0.4 2.6 0.6 0.5 0.2 1.2 -0.4 -0.6 -0.5 0.4 0.8 0.4 0.4 1.6 0.4 0.5 0.8 0.5 1.2 0.4 0.3 0.6 0.4 0.2 0.4 0.5 0.4 0.3 -0.3 0.6 0.6 0.5 0.4 -0.0
Medication: Levothyroxine sodium 0.3 0.5 3.0 -0.5 -0.5 -0.1 -0.0 0.1 -0.1 -0.2 -0.7 -1.5 -0.4 -0.7 -1.3 -0.6 -0.3 -0.2 -0.4 -0.8 -0.5 -0.7 -0.4 -0.7 -0.3 -1.7 -0.4 -0.7 -0.9 0.0 -0.1 -0.1 -0.5 -0.6 -1.2
Sitting height 0.2 1.6 11.8 -0.6 -0.1 -1.4 -0.9 -0.9 -0.9 -1.1 -0.5 -2.1 0.9 -0.7 0.4 -0.4 -0.2 -0.6 -1.2 -2.5 0.4 -1.1 -1.1 -1.8 -1.9 -3.4 0.0 -1.3 -1.6 -1.1 0.8 0.8 0.3 0.3 -1.5
Chronic bronchitis/emphysema (father) 0.8 1.0 2.9 1.0 1.1 1.1 -0.1 -0.9 -0.9 -0.6 1.0 1.7 0.7 1.0 -0.0 1.0 1.5 1.2 1.1 0.3 0.9 0.9 1.0 1.2 1.4 0.2 0.6 1.0 1.1 -0.8 1.0 1.0 1.1 0.9 0.8
High blood pressure (mother) 0.7 0.9 5.6 -0.9 -0.6 0.6 -2.4 1.0 0.7 1.3 -1.1 0.7 -1.5 -0.9 -0.7 -0.9 -0.2 -1.2 -1.0 -0.4 -1.5 -0.6 -0.9 -0.6 -0.8 -1.0 -1.2 -0.8 -0.7 0.7 -0.7 -0.7 -0.6 -1.0 -0.4
Body mass index (BMI) 0.1 0.4 1.3 -0.2 -0.4 0.8 0.6 1.0 1.0 1.0 -0.4 0.9 -1.1 -0.2 0.1 -0.3 0.0 -0.1 0.4 0.9 -1.1 0.0 0.1 0.7 0.6 -0.4 -0.5 0.2 0.3 0.9 -0.9 -1.0 -0.8 -0.9 -0.1
Impedance of leg (left) 0.1 0.6 1.9 0.7 0.9 0.3 0.0 -0.6 -0.8 -0.3 0.8 -0.4 0.5 1.0 0.6 0.8 0.8 1.1 0.6 -0.0 0.9 1.2 0.7 0.7 0.8 1.4 0.8 0.9 1.0 -0.4 0.8 0.8 1.0 1.0 1.4
Leg predicted mass (left) 1.0 5.5 14.5 -2.5 -2.4 -2.2 -1.8 1.9 1.9 1.6 -2.5 -1.5 -1.8 -2.7 -0.6 -2.5 -2.0 -2.7 -2.5 -2.1 -2.3 -2.7 -2.6 -2.6 -2.5 -3.8 -2.3 -2.7 -2.8 1.3 -1.9 -1.9 -2.2 -2.4 -3.2
Trunk fat mass 0.1 0.6 2.4 -0.8 -0.8 0.0 0.1 1.2 1.1 1.1 -0.7 0.2 -1.1 -0.6 0.5 -0.7 -0.3 -0.5 -0.3 -0.5 -1.2 -0.4 -0.6 -0.1 -0.0 -1.5 -0.8 -0.4 -0.2 0.9 -1.0 -1.1 -1.0 -1.0 -0.6
Waist circumference 0.4 1.3 2.8 -1.1 -1.3 -0.5 0.2 1.7 1.7 1.6 -1.2 -0.4 -1.6 -1.0 0.7 -1.2 -1.2 -0.9 -0.7 0.1 -1.7 -0.8 -0.7 -0.4 -0.4 -1.0 -1.2 -0.8 -0.7 1.5 -1.6 -1.6 -1.5 -1.5 -1.0
Number of incorrect matches in round 0.2 0.3 2.4 -0.1 -0.1 1.0 0.1 -0.1 0.2 -0.1 -0.1 -1.5 -0.0 -0.2 1.5 -0.1 -0.2 0.1 0.0 -0.7 -0.1 -0.2 -0.1 -0.2 0.1 1.0 0.2 -0.2 -0.2 0.6 -0.2 -0.2 -0.2 -0.2 0.3
Past tobacco smoking 0.5 0.9 5.1 -1.0 -0.7 -2.3 -1.5 0.1 0.4 0.1 -1.0 0.1 -0.7 -1.0 -0.5 -0.9 -0.6 -1.2 -1.2 -1.9 -0.6 -0.7 -1.2 -1.0 -1.2 -1.0 -0.6 -1.0 -1.0 0.1 -0.3 -0.5 -0.5 -0.8 -0.7
Alcohol usually taken with meals 0.4 0.7 1.9 -1.0 -0.9 -0.6 -0.7 0.9 0.8 1.1 -0.7 -0.0 -0.4 -0.9 0.6 -0.9 -1.0 -0.6 -0.8 -1.4 -0.3 -1.2 -1.1 -1.0 -0.9 -0.0 -1.3 -0.9 -0.8 0.5 -0.9 -0.9 -0.8 -0.8 -0.6
Nervous feelings 1.0 1.8 7.3 1.2 0.9 1.6 2.6 -0.8 -0.8 -0.9 1.5 -0.2 1.4 1.3 2.7 1.1 1.2 1.7 1.4 0.9 1.4 1.2 1.4 1.4 1.9 1.1 1.2 1.4 1.3 -0.7 0.9 0.9 0.9 1.2 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 5.0 -0.5 -0.8 -0.6 -1.1 0.8 0.7 0.9 -0.3 -1.9 -0.1 -0.5 -1.0 -0.5 -0.1 -0.4 -0.6 -0.2 -0.6 -0.9 -0.6 -0.5 -0.4 -2.2 -0.9 -0.5 -0.4 0.7 -0.7 -0.6 -0.8 -0.5 -1.6
Hearing difficulty/problems with background noise 0.2 0.3 1.2 -0.6 -0.4 0.2 -1.1 0.8 0.4 0.8 -0.6 0.6 -0.9 -0.4 -0.8 -0.6 -0.4 -0.3 -0.5 0.2 -0.8 -0.4 -0.3 -0.2 -0.3 0.5 -0.7 -0.5 -0.4 0.4 -0.3 -0.4 -0.3 -0.6 0.4
Hair/balding pattern: Pattern 2 2.2 2.7 6.8 -1.8 -1.3 -1.3 -2.6 0.7 0.7 0.7 -2.1 -0.8 -1.8 -2.0 -2.3 -1.9 -1.0 -2.0 -1.9 -2.2 -1.8 -1.8 -1.8 -2.1 -2.1 -1.7 -1.5 -2.0 -2.0 0.5 -0.7 -0.9 -0.9 -1.5 -1.3
Had menopause 0.2 0.3 2.1 -0.1 0.2 -1.2 -0.3 -0.5 -0.5 -0.3 0.0 -0.6 0.2 0.1 0.7 0.0 -0.1 -0.2 -0.1 -1.4 0.2 -0.2 0.0 -0.1 -0.1 -1.4 0.3 0.0 -0.0 -0.4 0.5 0.5 0.5 0.4 -0.2
Had other major operations 2.0 2.5 4.9 -1.8 -1.4 -1.8 -1.1 1.0 0.9 0.7 -2.1 -2.2 -2.2 -1.7 -2.2 -1.8 -1.5 -1.4 -1.5 -1.8 -1.9 -1.7 -1.6 -1.7 -1.6 -1.1 -0.9 -1.6 -1.7 1.0 -1.1 -1.2 -1.3 -1.6 -1.6
Forced vital capacity (FVC) 2.1 8.3 14.7 -3.2 -3.0 -2.1 -2.1 2.5 2.5 2.2 -2.9 -3.3 -1.7 -3.2 0.6 -3.0 -3.3 -3.0 -3.5 -3.0 -2.3 -3.2 -3.6 -3.8 -3.7 -1.4 -3.2 -3.7 -3.7 1.8 -2.6 -2.6 -2.8 -2.6 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 7.3 0.9 0.7 2.7 0.3 -0.5 -0.5 -0.5 1.3 0.7 1.2 1.0 -0.7 1.0 1.4 0.9 0.8 1.0 0.8 0.5 0.7 0.8 0.6 0.0 0.4 0.9 1.1 -0.5 0.4 0.5 0.6 0.8 1.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 2.6 -0.5 -0.3 -0.8 0.0 0.3 0.3 0.2 -0.6 -1.6 -0.5 -0.5 0.7 -0.4 -0.5 -0.2 -0.3 -0.7 -0.5 -0.7 -0.2 -0.5 -0.1 -0.3 -0.4 -0.4 -0.5 0.2 -0.2 -0.2 -0.3 -0.3 -0.8
Qualifications: None of the above 0.2 0.5 3.0 0.6 0.5 -0.2 -0.1 -0.4 -0.2 -0.5 0.7 1.3 0.5 0.7 -0.6 0.6 0.3 0.7 0.5 1.1 0.7 0.5 0.6 0.8 0.7 1.7 0.8 0.7 0.6 0.3 0.3 0.3 0.3 0.4 0.8
Financial difficulties in last 2 years 2.4 3.2 5.7 -1.9 -1.9 0.3 -1.8 2.1 2.2 2.0 -2.0 -2.0 -2.3 -1.8 -0.6 -1.9 -1.7 -1.7 -1.6 -0.1 -2.4 -1.8 -1.7 -1.5 -1.7 0.2 -1.8 -1.6 -1.5 2.3 -2.2 -2.3 -2.1 -2.1 -1.3
Mouth/teeth dental problems 0.9 1.3 5.2 -1.2 -0.9 -1.4 -1.4 0.3 0.3 0.3 -1.3 -0.6 -0.9 -1.4 -1.1 -1.2 -0.6 -1.3 -1.3 -2.0 -0.7 -1.5 -1.4 -1.5 -1.2 -2.3 -0.9 -1.3 -1.4 -0.1 -0.3 -0.4 -0.6 -0.9 -1.5
Heart attack 1.7 2.2 3.9 -1.3 -1.5 -1.0 -1.2 1.5 1.4 1.1 -1.4 -1.9 -0.8 -1.5 0.4 -1.3 -1.6 -1.7 -1.7 0.4 -1.6 -2.0 -1.5 -1.7 -1.7 -0.4 -1.5 -1.6 -1.8 1.9 -1.4 -1.4 -1.7 -1.5 -1.9
Allergy 0.2 0.4 1.8 0.5 0.7 0.3 0.4 -0.5 -0.6 -0.6 0.7 0.4 0.5 0.6 -0.0 0.7 0.4 0.5 0.6 -0.3 0.7 0.7 0.3 0.6 0.4 1.3 0.8 0.7 0.6 -0.1 0.4 0.4 0.5 0.6 0.9
Pain all over the body in last month 0.3 0.3 2.7 0.1 0.4 0.6 -1.6 -0.5 -0.4 -0.3 -0.3 0.7 -0.3 -0.1 -1.6 0.1 0.4 -0.2 0.1 -0.5 -0.3 -0.4 0.1 0.1 -0.1 -0.7 0.2 -0.1 -0.0 -1.0 0.5 0.5 0.4 -0.0 0.2
Diabetes (self-reported) 0.3 0.4 2.1 -0.0 -0.3 0.1 0.4 1.0 1.0 1.1 -0.1 -0.7 -0.5 -0.0 1.0 -0.0 -0.4 -0.2 0.0 1.5 -0.8 0.0 0.1 0.4 0.3 0.6 -0.6 0.2 0.3 1.1 -0.9 -0.9 -0.7 -0.5 -0.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 1.6 -0.1 -0.4 -0.9 -0.6 0.1 0.2 0.1 -0.1 0.2 0.3 -0.3 1.3 -0.2 -0.2 -0.3 -0.3 0.3 -0.2 -0.5 -0.3 -0.3 -0.3 -0.6 -0.4 -0.3 -0.4 0.1 -0.1 -0.0 -0.3 -0.2 -0.9
Medication: Ramipril 0.2 0.2 2.5 -0.4 -0.3 -1.4 0.3 0.2 0.1 -0.1 -0.4 -1.6 -0.2 -0.3 0.2 -0.3 -0.6 -0.5 -0.6 -0.8 -0.2 -0.3 -0.3 -0.4 -0.1 -0.0 -0.2 -0.4 -0.4 0.4 -0.3 -0.3 -0.2 -0.2 0.4
Medication: Simvastatin 0.6 0.8 2.2 1.1 0.9 1.0 0.8 -0.8 -0.8 -0.9 1.1 0.7 1.4 1.1 -0.5 1.2 0.6 0.5 0.7 1.5 1.0 0.8 0.9 0.6 0.4 1.3 0.5 0.7 0.6 -0.8 0.8 0.9 0.8 1.1 1.1
Fluid intelligence score 0.4 0.9 2.8 0.7 1.0 0.4 0.2 -1.6 -1.6 -1.6 0.7 -0.3 1.2 0.5 -0.4 0.8 1.2 0.7 0.6 -0.9 1.3 0.5 0.5 0.2 0.3 -0.6 0.9 0.4 0.3 -1.7 1.5 1.5 1.2 1.1 0.4
Illnesses of siblings 1.7 2.3 4.8 -1.6 -1.7 -1.0 -1.0 1.7 1.9 1.7 -1.9 -1.4 -2.2 -1.5 -1.4 -1.7 -1.6 -1.3 -1.4 0.1 -1.9 -0.9 -1.4 -1.3 -1.3 -0.1 -1.4 -1.3 -1.3 1.9 -1.8 -1.9 -1.8 -1.7 -1.6
Neuroticism score 0.5 1.1 2.8 0.9 1.0 1.7 1.3 -0.8 -1.0 -0.8 1.0 -1.1 0.9 1.0 0.8 0.9 1.4 1.6 1.3 0.0 0.9 0.8 1.1 1.1 1.2 0.9 0.9 1.0 1.1 -0.9 1.0 1.0 1.1 1.1 0.9
Weight 0.3 1.4 5.4 -1.2 -1.2 -0.9 -0.5 1.2 1.2 1.0 -1.3 -0.6 -1.3 -1.3 0.2 -1.2 -0.9 -1.2 -1.0 -1.0 -1.5 -1.2 -1.1 -1.0 -0.9 -2.3 -1.2 -1.2 -1.2 0.8 -1.1 -1.2 -1.2 -1.3 -1.5
Impedance of arm (right) 0.5 2.2 3.8 1.5 1.5 0.4 1.1 -1.6 -1.6 -1.5 1.9 0.7 1.5 1.8 0.2 1.6 1.6 1.5 1.4 -0.0 1.9 1.8 1.4 1.5 1.5 1.0 1.9 1.9 1.9 -1.4 1.5 1.5 1.6 1.8 1.4
Arm fat percentage (right) 0.2 0.6 2.1 0.4 0.2 1.4 1.2 0.5 0.5 0.6 0.3 1.3 -0.8 0.6 0.1 0.3 0.7 0.6 1.0 1.0 -0.6 0.9 0.8 1.4 1.3 -0.1 0.2 1.0 1.3 0.5 -0.4 -0.5 -0.2 -0.2 0.7
Trunk fat-free mass 1.6 9.4 15.5 -3.3 -3.1 -2.6 -2.4 2.6 2.5 2.4 -3.5 -2.6 -2.5 -3.5 -0.3 -3.3 -3.1 -3.5 -3.5 -2.6 -3.0 -3.5 -3.4 -3.7 -3.6 -3.7 -3.2 -3.8 -3.9 1.8 -2.4 -2.5 -2.9 -3.0 -3.9
Hip circumference 0.1 0.3 1.9 0.4 0.4 0.5 1.2 -0.1 -0.2 -0.1 0.4 0.9 0.1 0.5 -0.1 0.4 0.8 0.5 0.7 0.4 0.1 0.5 0.5 0.9 0.9 -1.4 0.2 0.6 0.7 -0.6 0.3 0.2 0.3 0.1 0.2
Time employed in main current job 0.9 1.1 3.8 -1.2 -0.7 -1.9 -1.0 0.8 0.6 0.9 -1.4 0.7 -1.4 -1.1 0.2 -1.1 -1.4 -1.1 -1.2 -1.1 -1.0 -1.2 -1.0 -1.1 -1.2 0.2 -1.1 -1.1 -1.1 0.4 -0.6 -0.7 -0.6 -0.9 -0.7
Alcohol intake versus 10 years previously 0.1 0.1 1.5 -0.1 -0.1 -0.0 0.0 -0.1 0.3 0.1 -0.2 1.2 -0.1 -0.2 -0.6 -0.1 -0.3 -0.3 -0.1 -0.1 -0.3 0.0 -0.1 -0.1 -0.2 0.1 -0.1 -0.3 -0.3 0.4 -0.3 -0.3 -0.3 -0.3 0.3
Father’s age at death 1.2 1.6 6.3 1.4 1.1 1.1 2.0 -1.1 -1.0 -0.8 1.3 0.2 1.3 1.2 2.5 1.3 1.0 1.5 1.3 1.2 1.3 1.2 1.5 1.1 1.2 1.1 1.0 1.2 1.2 -1.2 1.1 1.2 1.1 1.3 0.1
Worrier / anxious feelings 0.7 1.3 2.9 1.0 1.4 0.8 0.7 -1.4 -1.6 -1.2 0.9 -0.2 1.2 1.0 1.2 1.1 1.3 1.6 0.6 -0.9 1.5 0.5 0.9 0.4 0.6 0.5 0.9 0.6 0.5 -1.7 1.6 1.6 1.5 1.3 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 4.0 -0.6 -0.6 0.3 0.3 0.5 0.4 0.4 -0.7 -2.0 -0.6 -0.6 0.1 -0.7 -0.0 -0.2 -0.4 -1.0 -0.7 -0.6 -0.3 -0.6 -0.6 -1.4 -0.5 -0.6 -0.6 0.4 -0.3 -0.4 -0.5 -0.7 -0.8
Falls in the last year 0.3 0.4 2.2 -0.3 -0.4 1.5 -0.8 0.7 0.8 0.4 -0.2 0.7 -0.7 -0.1 -0.7 -0.2 -0.3 -0.4 0.3 0.9 -0.7 0.1 -0.2 0.2 0.7 0.9 -0.1 0.0 0.1 0.9 -0.9 -0.9 -0.7 -0.6 0.1
Hair/balding pattern: Pattern 3 0.2 0.3 2.1 0.4 0.3 1.4 -0.1 0.1 -0.0 0.0 0.7 -0.1 0.2 0.7 -1.0 0.5 0.2 0.7 0.7 0.6 0.3 0.7 0.6 0.7 0.6 0.5 0.3 0.8 1.0 0.3 -0.1 0.0 0.2 0.4 0.9
Number of live births 0.1 0.1 1.2 0.1 0.3 0.5 -0.5 -0.3 -0.4 -0.3 -0.1 0.2 -0.1 -0.1 0.1 0.1 0.1 0.2 0.0 0.4 -0.1 -0.1 -0.1 -0.2 -0.5 1.1 0.1 -0.1 -0.2 -0.2 0.3 0.3 0.3 0.1 0.1
Forced expiratory volume in 1-second (FEV1) 3.7 12.6 20.6 -3.9 -3.9 -2.6 -2.6 3.2 3.3 2.9 -3.7 -3.2 -2.4 -4.0 -0.2 -3.8 -4.1 -4.0 -4.2 -2.8 -3.1 -4.1 -4.3 -4.5 -4.4 -1.7 -4.0 -4.4 -4.5 2.5 -3.5 -3.4 -3.7 -3.5 -3.4
Pulse rate 1.8 3.1 5.5 -1.7 -2.1 -1.5 -0.4 2.0 2.0 2.1 -1.6 -1.4 -1.2 -1.8 1.9 -1.9 -2.1 -1.3 -1.9 -1.3 -1.4 -2.1 -1.6 -1.9 -1.5 -0.2 -2.3 -1.8 -1.8 1.9 -1.9 -1.9 -2.0 -1.8 -2.1
Happiness 0.1 0.2 1.3 0.3 0.4 -0.2 -0.3 -0.4 -0.6 -0.6 0.2 0.0 0.2 0.2 -1.1 0.2 0.5 0.0 -0.0 -0.2 0.1 -0.2 0.2 -0.0 0.2 -1.1 0.4 0.1 0.1 -0.7 0.6 0.5 0.4 0.2 -0.1
Noisy workplace 0.2 0.2 0.9 0.3 0.1 0.2 0.1 -0.4 -0.4 -0.6 0.7 -0.1 0.8 0.4 -0.0 0.3 0.5 0.9 0.4 -0.9 0.8 0.6 0.0 0.4 0.6 -0.4 0.7 0.3 0.3 0.1 0.1 0.2 0.2 0.3 0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.4 0.5 0.3 0.1 0.3 -0.4 -0.4 -0.1 0.3 -0.4 0.2 0.5 1.2 0.3 0.3 0.2 0.2 0.9 0.3 0.4 0.8 0.4 0.6 0.4 0.4 0.4 0.4 -0.8 0.4 0.4 0.4 0.5 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 -0.5 -0.6 -0.4 0.2 0.7 0.6 0.7 -0.6 0.7 -0.7 -0.6 0.0 -0.6 -0.7 -0.9 -0.5 0.4 -0.5 -0.7 -0.5 -0.6 -0.2 -0.0 -0.8 -0.6 -0.6 0.0 -0.5 -0.6 -0.7 -0.7 -0.7
Mouth/teeth dental problems: Dentures 2.8 4.8 7.9 2.5 2.4 1.5 1.4 -1.9 -2.0 -1.9 2.4 2.2 2.2 2.6 0.4 2.5 1.8 2.0 2.1 2.6 2.3 2.4 2.5 2.1 1.8 2.5 2.4 2.4 2.3 -1.6 2.0 2.1 2.2 2.5 2.8
Asthma 0.6 1.2 2.4 1.1 1.2 0.0 0.8 -1.2 -1.5 -1.1 1.4 0.4 1.4 1.2 -0.5 1.1 1.4 1.5 1.1 -0.6 1.5 1.1 0.9 0.9 0.8 -0.4 1.1 1.1 1.1 -1.2 1.4 1.4 1.3 1.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.0 0.4 0.3 0.7 1.2 -0.2 -0.4 -0.4 0.5 0.8 0.2 0.5 0.7 0.4 0.8 0.8 0.8 0.6 0.4 0.7 0.6 0.7 1.4 0.1 0.5 0.6 0.6 -0.1 0.3 0.2 0.3 0.3 0.0
Medication: Cholesterol lowering 1.4 2.2 7.1 1.6 1.5 2.3 2.0 -0.9 -1.1 -1.0 1.3 0.4 1.1 1.6 0.9 1.6 1.2 1.5 1.5 2.5 1.1 1.5 1.7 1.4 1.3 2.7 1.3 1.4 1.3 -0.9 1.1 1.1 1.1 1.3 1.9
Depression (self-reported) 0.4 0.5 0.9 -0.6 -0.7 0.2 -0.6 0.8 0.9 0.7 -0.5 -0.1 -0.4 -0.6 -0.9 -0.5 -0.5 -0.6 -0.6 0.4 -0.8 -0.9 -0.7 -0.7 -0.5 -0.5 -0.8 -0.7 -0.6 0.7 -0.9 -0.8 -0.9 -0.8 -0.6
Medication: Lansoprazole 0.4 0.4 2.2 -0.8 -0.5 0.4 -1.2 0.3 0.3 0.0 -0.7 -0.1 -0.6 -0.9 -1.5 -0.7 -0.4 -0.3 -0.6 -1.1 -0.5 -0.9 -0.8 -0.7 -0.5 0.3 -0.6 -0.7 -0.8 0.3 -0.4 -0.4 -0.6 -0.9 -0.5
Prospective memory result 0.3 0.4 2.7 -0.5 -0.1 -0.5 -1.0 -0.0 0.0 -0.1 -0.5 -1.0 -0.0 -0.5 -1.6 -0.2 -0.4 -0.6 -0.7 -1.2 -0.2 -0.6 -0.7 -0.9 -0.7 -0.0 -0.4 -0.7 -0.8 -0.1 -0.1 -0.1 -0.2 -0.2 -0.1
Lung cancer (father) 0.9 1.1 3.4 -1.2 -1.0 0.5 -0.8 1.2 1.2 1.1 -1.2 0.3 -1.4 -0.9 -1.8 -1.0 -0.9 -0.8 -1.0 -0.4 -1.3 -0.9 -1.1 -0.9 -0.7 1.1 -0.9 -1.0 -0.9 1.0 -1.3 -1.2 -1.1 -1.3 0.2
Illnesses of mother 0.3 0.3 1.5 -0.5 -0.7 -0.2 0.2 1.0 1.0 0.9 -0.2 -0.5 -0.5 -0.3 -0.3 -0.4 -0.4 0.2 -0.1 0.0 -0.3 -0.2 -0.5 -0.0 0.1 1.2 -0.4 0.0 0.1 1.1 -1.0 -1.0 -0.8 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 3.4 10.7 18.4 -3.5 -3.4 -2.6 -3.0 2.5 2.7 2.2 -3.4 -3.2 -1.9 -3.7 -0.5 -3.4 -3.5 -3.8 -4.0 -2.8 -2.8 -3.9 -4.1 -4.3 -4.2 -2.5 -3.6 -4.2 -4.3 2.1 -2.9 -2.9 -3.2 -3.1 -3.4
Pulse wave Arterial Stiffness index 0.6 0.7 1.5 0.8 1.0 0.7 1.0 -0.3 -0.6 0.1 0.6 0.7 -0.1 1.1 0.2 0.8 0.8 0.8 0.9 0.8 0.2 1.2 1.2 1.1 1.1 1.0 0.7 1.1 1.2 -0.6 0.8 0.8 1.0 0.9 1.2
Impedance of arm (left) 0.7 3.2 5.1 1.9 1.9 0.5 0.8 -2.0 -2.0 -1.7 2.3 1.0 1.7 2.1 0.0 1.9 2.1 1.9 1.7 -0.0 2.1 2.1 1.7 1.8 1.9 0.4 2.1 2.2 2.3 -1.7 1.9 1.9 2.0 2.1 1.8
Arm fat mass (right) 0.1 0.4 1.4 -0.4 -0.5 0.3 0.4 0.9 0.9 0.9 -0.4 0.3 -1.0 -0.3 0.1 -0.4 0.0 -0.2 0.2 0.1 -1.1 -0.1 -0.1 0.5 0.5 -1.2 -0.5 0.1 0.2 0.9 -0.8 -0.9 -0.7 -0.8 -0.5
Trunk predicted mass 1.6 9.0 15.0 -3.2 -3.0 -2.6 -2.3 2.5 2.4 2.3 -3.4 -2.6 -2.4 -3.4 -0.4 -3.2 -3.0 -3.4 -3.4 -2.5 -2.9 -3.4 -3.3 -3.6 -3.6 -3.5 -3.1 -3.7 -3.8 1.8 -2.4 -2.5 -2.8 -3.0 -3.9
Standing height 0.7 6.5 18.1 -2.5 -2.0 -4.0 -2.5 0.8 0.7 0.6 -2.4 -2.9 -0.7 -2.7 0.1 -2.4 -2.4 -2.7 -3.3 -4.2 -1.1 -3.0 -3.0 -3.8 -3.5 -4.3 -1.9 -3.3 -3.5 0.1 -0.8 -0.8 -1.4 -1.4 -3.3
Length of working week for main job 0.2 0.3 3.4 0.1 0.5 -0.6 -0.3 -0.5 -0.5 -0.6 -0.1 0.1 0.1 0.1 -1.9 0.2 -0.1 -0.0 -0.2 -0.0 0.3 -0.2 0.1 -0.3 0.1 0.5 0.3 -0.1 -0.2 -1.0 0.5 0.4 0.5 0.3 1.0
Exposure to tobacco smoke at home 1.2 1.4 3.6 -1.3 -1.1 -1.0 -1.0 1.3 1.2 0.8 -1.4 -0.4 -1.8 -1.2 -0.1 -1.3 -1.2 -1.9 -1.2 -0.1 -1.7 -0.9 -1.0 -0.9 -1.0 -0.8 -0.6 -1.1 -1.1 1.5 -1.3 -1.5 -1.3 -1.4 -0.4
Breastfed as a baby 2.4 3.0 5.5 -1.9 -1.9 -0.9 -1.3 2.0 1.9 1.9 -1.9 0.2 -1.5 -1.8 -0.8 -1.9 -1.9 -2.4 -2.0 -0.4 -1.8 -1.7 -1.8 -1.9 -2.1 -1.2 -2.1 -2.1 -2.0 1.4 -1.9 -1.9 -1.9 -1.9 -1.0
Tense / ‘highly strung’ 1.3 2.1 3.7 1.5 1.3 1.9 1.7 -1.4 -1.4 -1.6 1.7 -0.3 1.9 1.5 0.9 1.5 1.9 1.7 1.6 0.4 1.6 1.0 1.5 1.3 1.9 0.2 1.5 1.4 1.4 -1.4 1.4 1.5 1.4 1.6 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 7.1 -1.3 -0.8 -0.2 -0.3 0.6 0.5 0.6 -1.5 -2.7 -1.2 -1.4 -0.6 -1.2 -0.9 -0.7 -1.0 -1.6 -1.2 -1.5 -1.1 -1.4 -1.1 -0.8 -1.2 -1.5 -1.5 0.2 -0.5 -0.6 -0.7 -1.0 -1.2
Hair/balding pattern: Pattern 4 2.6 6.4 10.2 3.0 2.5 0.9 3.2 -2.8 -2.7 -2.8 2.8 1.9 2.6 2.7 1.1 2.7 2.7 2.6 2.7 2.2 2.7 2.2 2.9 2.8 2.7 0.1 2.9 2.8 2.5 -2.5 2.8 2.8 2.5 2.5 1.7
Birth weight of first child 0.5 0.9 6.1 -0.4 0.3 -1.6 -0.7 -1.0 -0.9 -1.1 -0.6 -1.8 0.2 -0.4 -1.4 -0.2 -0.3 -0.5 -0.6 -2.5 0.3 -0.5 -0.6 -1.1 -1.0 -0.5 0.4 -0.8 -1.0 -1.4 0.9 0.7 0.6 0.3 -0.2
Peak expiratory flow (PEF) 4.5 10.3 16.3 -3.4 -3.5 -2.5 -2.6 2.8 2.9 2.6 -3.2 -2.7 -2.0 -3.6 -1.7 -3.3 -3.4 -3.5 -3.8 -2.6 -2.8 -3.8 -4.0 -4.0 -3.9 -2.6 -3.7 -3.8 -3.9 2.1 -3.0 -2.9 -3.4 -3.3 -3.7
Pulse wave reflection index 0.9 1.2 3.7 0.9 1.4 1.2 -0.1 -1.0 -1.2 -0.8 0.9 0.2 0.5 1.1 -1.9 1.1 1.2 1.0 1.1 -0.3 0.6 1.1 0.9 1.0 0.9 0.5 1.1 1.1 1.2 -1.2 1.2 1.1 1.4 1.2 1.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.5 -0.4 -0.6 0.7 1.4 1.3 0.9 1.3 -0.5 -1.2 -1.0 -0.3 1.6 -0.6 -0.6 0.2 -0.1 1.2 -0.8 0.1 -0.2 -0.0 -0.0 1.0 -0.9 -0.1 -0.0 0.4 -0.9 -0.9 -0.7 -0.5 -0.3
Loud music exposure frequency 0.3 0.3 4.5 -0.4 -0.4 -0.6 0.4 0.5 0.5 0.4 -0.5 -0.7 -0.8 -0.4 -2.1 -0.4 -0.3 -0.1 -0.3 0.1 -0.5 -0.0 -0.4 -0.2 -0.2 -0.0 -0.4 -0.2 -0.2 0.4 -0.5 -0.5 -0.5 -0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 1.8 0.3 0.1 1.0 1.3 -0.2 0.1 -0.1 0.3 -0.5 0.4 0.3 1.3 0.3 -0.0 0.0 0.3 0.7 0.2 0.4 0.4 0.2 0.3 0.1 0.3 0.2 0.1 -0.3 -0.2 -0.1 -0.2 0.2 -0.0
Mouth/teeth dental problems: Bleeding gums 3.3 4.2 6.7 -2.2 -2.5 -1.6 -2.0 2.2 2.5 2.2 -1.9 -1.1 -1.5 -2.1 -0.1 -2.1 -2.1 -1.9 -2.2 -1.6 -2.2 -2.1 -2.2 -1.8 -1.9 -0.7 -2.5 -2.0 -2.0 2.6 -2.5 -2.4 -2.5 -2.3 -2.1
Blood clot in the leg (DVT) 4.8 6.2 8.9 2.8 2.7 1.6 2.9 -2.7 -2.6 -2.9 2.8 0.8 2.9 2.9 0.2 2.8 2.5 2.5 2.5 1.6 2.8 2.4 2.6 2.3 2.3 0.7 3.0 2.5 2.4 -2.8 2.6 2.6 2.7 2.9 2.7
Medication: Paracetamol 0.2 0.3 1.9 0.4 0.1 0.8 1.2 0.1 0.2 0.1 0.3 0.5 0.4 0.3 1.4 0.3 0.5 0.5 0.4 1.1 0.3 0.2 0.5 0.4 0.6 1.2 -0.1 0.2 0.2 0.1 -0.1 -0.0 -0.1 0.1 0.0
Headache pain in last month 1.8 3.1 11.2 1.6 1.0 2.1 2.5 -0.2 -0.1 -0.3 1.7 0.6 0.8 1.8 2.8 1.5 1.2 2.2 1.9 3.1 1.0 2.2 1.9 2.3 2.5 3.3 1.2 2.0 2.1 0.6 0.2 0.2 0.5 1.0 1.7
Medication for cholesterol, blood pressure or diabetes 1.4 2.2 4.4 -1.7 -1.7 -1.6 -1.7 1.3 1.5 1.4 -1.3 -0.3 -1.2 -1.6 -0.6 -1.6 -1.5 -1.5 -1.6 -2.1 -1.1 -1.8 -1.9 -1.6 -1.3 -1.2 -1.4 -1.5 -1.4 1.1 -1.6 -1.5 -1.6 -1.5 -1.7
Glaucoma (self-reported) 0.3 0.4 2.0 0.5 0.4 -0.1 1.1 -0.5 -0.5 -0.2 0.5 1.3 0.7 0.4 0.9 0.5 0.3 0.9 0.5 -0.1 0.9 0.4 0.5 0.4 0.7 1.4 -0.0 0.4 0.4 -0.8 0.5 0.5 0.5 0.5 0.3
Gout (self-reported) 0.5 0.7 1.9 -0.8 -1.1 -0.4 -0.2 1.1 1.2 0.8 -0.7 0.2 -0.3 -0.8 -0.1 -0.8 -1.4 -1.1 -0.9 0.1 -0.6 -1.0 -0.8 -0.9 -0.9 0.7 -0.8 -0.9 -0.9 0.9 -1.2 -1.1 -1.2 -0.9 -0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 4.9 -0.3 -0.3 -0.0 -0.6 -0.2 -0.3 -0.6 -0.4 -1.5 0.2 -0.7 -0.6 -0.3 0.0 -0.1 -0.3 -0.8 -0.1 -0.6 -0.5 -0.7 -0.4 -2.2 -0.2 -0.7 -0.9 -0.1 0.2 0.2 -0.3 -0.4 -1.6
Medication: Amlodipine 0.2 0.3 3.4 0.2 -0.3 0.7 1.2 0.6 0.5 0.4 0.4 0.3 0.4 0.3 1.8 0.2 -0.3 0.1 0.1 1.0 0.2 0.0 0.2 0.2 0.5 0.7 -0.2 0.3 0.3 0.5 -0.6 -0.5 -0.5 -0.0 0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.4 0.9 1.0 0.4 0.2 -1.1 -1.3 -1.0 1.4 1.0 1.4 1.1 -1.2 1.1 1.6 0.8 0.7 -0.9 1.4 0.9 0.6 0.8 1.0 -0.9 0.9 1.0 1.1 -1.2 1.2 1.1 1.1 1.2 0.5
Birth weight 1.8 4.0 8.9 -2.0 -2.0 -2.6 -1.2 1.4 1.5 1.3 -2.0 0.3 -1.2 -2.1 -1.8 -2.0 -2.3 -3.0 -2.6 -1.4 -1.8 -2.3 -2.0 -2.6 -2.8 -2.3 -1.8 -2.5 -2.6 0.7 -1.5 -1.5 -1.8 -1.8 -2.1
Chronic bronchitis/emphysema (mother) 1.0 1.1 3.9 1.1 1.0 0.1 1.2 -1.0 -0.9 -1.0 0.7 1.8 0.5 1.1 -0.6 0.9 0.8 0.8 1.1 1.7 0.8 1.0 1.4 1.1 1.0 2.0 1.0 0.9 0.9 -0.7 1.0 1.0 1.0 0.9 1.2
High blood pressure (siblings) 0.5 0.7 3.1 0.6 0.7 0.5 0.3 -1.0 -1.1 -0.9 1.0 1.8 1.4 0.5 -0.6 0.8 0.8 0.4 0.5 -0.9 1.1 -0.0 0.5 0.3 0.5 -1.2 0.4 0.3 0.3 -1.3 1.0 1.1 0.8 0.6 0.6
Forced vital capacity (FVC), Best measure 1.8 6.4 13.1 -2.8 -2.5 -2.0 -2.3 1.7 1.8 1.5 -2.6 -2.9 -1.1 -2.9 0.2 -2.5 -2.7 -2.8 -3.2 -3.1 -1.8 -3.0 -3.3 -3.6 -3.5 -2.0 -2.8 -3.4 -3.5 1.2 -1.9 -1.9 -2.2 -2.2 -2.4
Body fat percentage 0.2 0.6 2.2 0.5 0.4 1.3 1.0 0.4 0.3 0.5 0.5 1.1 -0.6 0.7 0.6 0.5 0.9 0.8 1.1 0.8 -0.4 1.0 0.8 1.5 1.4 -0.3 0.2 1.1 1.4 0.4 -0.2 -0.3 0.1 0.0 0.9
Leg fat percentage (right) 0.3 1.0 3.6 0.5 0.3 1.9 1.3 0.7 0.7 0.9 0.4 1.0 -1.0 0.8 1.0 0.4 0.8 1.0 1.2 1.6 -0.7 1.2 1.0 1.7 1.5 0.4 0.1 1.3 1.6 0.8 -0.5 -0.6 -0.1 -0.1 1.1
Arm fat-free mass (right) 1.1 5.6 11.6 -2.5 -2.3 -2.1 -1.9 1.9 1.8 1.7 -2.8 -2.0 -1.9 -2.7 -0.1 -2.5 -2.3 -2.6 -2.6 -2.1 -2.3 -2.7 -2.6 -2.8 -2.7 -3.4 -2.4 -3.0 -3.0 1.4 -1.8 -1.9 -2.1 -2.3 -2.9
Exposure to tobacco smoke outside home 0.1 0.2 3.6 0.0 0.2 0.1 -0.2 -0.4 -0.5 -0.6 0.1 -0.1 0.2 -0.0 1.9 0.1 0.4 0.1 -0.0 -0.5 0.3 -0.1 -0.0 -0.0 -0.1 -0.2 0.4 -0.0 -0.1 -0.0 0.4 0.4 0.3 0.2 0.1
Comparative body size at age 10 0.2 0.6 5.9 0.6 0.8 2.4 -0.2 -0.6 -0.6 -0.5 0.7 0.8 0.5 0.6 0.3 0.7 1.0 0.6 1.0 0.4 0.5 0.7 0.5 0.7 0.8 0.3 0.7 0.6 0.7 -0.4 0.6 0.6 0.8 0.7 1.2
Number of full brothers 1.4 1.8 2.7 -1.3 -1.4 -1.1 -0.3 1.4 1.4 1.4 -1.3 -1.6 -1.2 -1.3 0.0 -1.4 -1.5 -1.4 -1.3 -0.9 -1.4 -1.6 -1.2 -1.3 -1.2 -1.1 -1.5 -1.3 -1.3 1.5 -1.4 -1.4 -1.5 -1.5 -1.6
Worry too long after embarrassment 0.1 0.2 1.7 -0.6 -0.1 0.2 -0.1 0.1 -0.2 0.3 -0.7 -0.2 -1.0 -0.5 0.3 -0.6 0.3 0.2 -0.1 -1.3 -0.7 -0.5 -0.3 -0.2 -0.4 -0.3 -0.1 -0.5 -0.4 -0.3 0.2 0.1 0.2 -0.3 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 5.7 -1.0 -1.2 -0.7 -1.0 0.7 0.8 0.6 -1.0 -1.8 -0.7 -1.3 -0.2 -1.1 -0.9 -1.3 -1.0 -0.5 -1.2 -2.0 -1.2 -1.4 -1.0 -2.2 -1.2 -1.2 -1.3 0.6 -0.9 -0.9 -1.2 -1.2 -2.4
Wheeze or whistling in the chest in last year 0.1 0.2 3.0 -0.3 -0.2 0.8 -0.3 0.3 0.1 0.4 -0.1 0.3 -0.3 -0.1 -1.7 -0.2 0.2 0.0 -0.3 -0.9 -0.3 0.2 -0.4 -0.2 -0.3 0.2 -0.5 -0.2 -0.2 0.3 -0.2 -0.1 -0.2 -0.3 0.1
Number of children fathered 0.4 0.4 5.2 0.1 -0.5 0.2 0.4 0.9 0.8 0.7 -0.0 0.6 0.2 0.1 1.2 -0.0 -0.6 -0.6 -0.6 2.3 -0.2 -0.2 -0.1 -0.4 -0.3 0.7 -0.6 -0.2 -0.2 0.5 -0.8 -0.7 -0.7 -0.3 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 4.4 -0.2 -0.1 0.2 -0.3 -0.2 -0.0 -0.0 -0.4 -1.5 -0.0 -0.4 2.1 -0.2 -0.3 0.1 -0.2 -0.7 -0.2 -0.6 -0.4 -0.5 -0.3 -0.0 -0.3 -0.6 -0.6 0.2 0.1 0.1 0.0 -0.1 -0.1
Age at first live birth 0.8 1.4 3.2 -1.3 -1.3 -1.7 -0.6 0.7 0.6 0.8 -1.4 -0.9 -1.0 -1.5 0.3 -1.4 -1.1 -1.3 -1.4 -1.1 -0.9 -1.8 -1.1 -1.6 -1.1 -1.5 -1.0 -1.5 -1.6 -0.1 -0.7 -0.7 -1.0 -1.1 -1.7
Pulse wave peak to peak time 1.0 1.2 2.3 -1.1 -1.2 -0.8 -1.2 0.6 0.8 0.1 -1.0 -1.0 -0.2 -1.4 -0.1 -1.1 -1.1 -1.1 -1.2 -1.1 -0.5 -1.4 -1.5 -1.4 -1.4 -1.2 -0.9 -1.4 -1.5 0.8 -1.0 -1.0 -1.2 -1.2 -1.5
Health satisfaction 0.4 0.5 3.9 0.0 -0.5 1.5 1.0 1.1 1.0 1.0 -0.1 -0.1 -0.7 0.1 0.9 -0.2 -0.0 0.0 0.3 2.0 -0.9 -0.0 0.4 0.5 0.5 0.1 -0.5 0.3 0.4 0.8 -0.9 -0.9 -0.8 -0.5 -0.3
Shortness of breath walking on level ground 1.2 1.4 7.0 -1.1 -1.4 -0.3 -0.8 1.3 1.4 1.1 -1.2 -0.3 -1.2 -1.1 -2.6 -1.2 -1.2 -1.3 -1.1 0.1 -1.3 -1.0 -0.8 -1.0 -0.8 -0.5 -1.0 -1.1 -1.0 1.5 -1.5 -1.5 -1.5 -1.3 -1.1
Qualifications: College or University degree 0.2 0.6 2.1 0.4 0.4 0.1 -0.6 -1.2 -1.1 -1.2 0.7 -0.0 1.4 0.1 -0.9 0.4 0.7 0.3 0.1 -1.2 1.2 -0.3 0.0 -0.4 -0.1 -1.5 0.3 0.1 -0.0 -1.4 0.9 1.1 0.7 0.7 -0.7
Eye problems/disorders: None of the above 1.4 1.7 4.4 -1.4 -1.2 0.9 -1.6 0.9 1.0 0.6 -1.5 -2.1 -1.4 -1.4 -0.8 -1.4 -0.8 -1.6 -1.2 -0.9 -1.7 -1.5 -1.2 -1.5 -1.4 -1.6 -0.7 -1.3 -1.4 1.1 -1.0 -1.1 -1.2 -1.3 -1.1
Mouth/teeth dental problems: Loose teeth 0.5 0.5 2.8 0.8 0.8 1.3 0.1 -0.5 -0.5 -0.4 0.6 -0.3 0.3 0.8 -0.6 0.8 0.9 0.5 0.9 1.7 0.0 0.9 0.8 1.0 1.0 0.2 0.6 0.8 0.8 -0.1 0.6 0.5 0.6 0.6 0.6
Emphysema/chronic bronchitis 0.4 0.5 1.6 -0.6 -0.5 -0.6 -1.0 0.6 0.4 0.6 -0.8 -0.4 -0.5 -0.5 1.3 -0.6 -0.7 -1.0 -1.0 -0.0 -0.7 -0.9 -0.6 -0.9 -1.0 -1.3 -0.7 -0.7 -0.7 0.0 -0.3 -0.3 -0.4 -0.4 -0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 1.3 0.2 0.5 -0.6 -0.4 -1.0 -0.8 -0.8 -0.1 -1.1 0.1 0.1 -0.7 0.2 0.2 -0.2 -0.1 -0.8 0.2 0.0 0.1 -0.2 -0.4 -1.0 0.4 0.0 -0.1 -1.1 0.9 0.8 0.7 0.5 0.2
Neck or shoulder pain in last month 1.0 1.4 8.8 0.9 0.7 1.4 1.4 -0.2 -0.2 -0.4 1.0 0.1 0.4 1.1 3.0 0.9 0.7 1.3 1.3 1.7 0.6 1.5 1.2 1.5 1.4 2.6 0.9 1.2 1.3 0.4 0.2 0.1 0.4 0.7 1.3
Medication: Blood pressure 0.1 0.2 2.3 0.3 0.1 0.2 0.9 0.1 -0.0 -0.1 0.1 -0.5 0.2 0.1 1.3 0.2 -0.0 0.2 0.3 1.5 0.0 0.3 0.4 0.4 0.2 0.4 -0.2 0.1 0.1 0.4 0.1 0.1 -0.0 0.1 -0.2
Angina (self-reported) 1.6 2.1 7.6 1.9 1.5 -0.2 1.4 -1.4 -1.2 -1.2 1.6 2.0 1.4 1.7 -0.1 1.8 1.2 1.0 1.3 2.8 1.2 1.3 1.9 1.5 1.2 1.1 1.6 1.5 1.4 -1.1 1.3 1.4 1.3 1.5 1.4
Migraine (self-reported) 0.1 0.1 1.0 0.2 0.3 0.4 0.0 -0.2 -0.3 0.1 0.3 1.0 0.0 0.2 -0.5 0.1 0.7 0.5 0.2 -0.1 0.3 0.3 0.3 0.2 0.4 -0.5 0.1 0.3 0.4 -0.4 0.3 0.3 0.3 0.2 -0.1
Medication: Ibuprofen 0.2 0.2 1.1 0.2 0.1 1.1 0.7 0.1 -0.2 0.0 0.4 0.9 0.2 0.3 0.3 0.1 0.7 0.5 0.5 0.4 0.3 0.6 0.4 0.5 1.0 -0.1 0.1 0.3 0.4 -0.1 0.1 0.1 0.1 0.1 -0.2
Medication: Allopurinol 0.3 0.4 1.3 -0.4 -0.8 -0.7 -0.4 0.7 0.9 0.4 -0.2 0.7 -0.0 -0.4 0.1 -0.4 -0.9 -0.8 -0.5 0.7 -0.4 -0.8 -0.5 -0.4 -0.4 0.9 -0.3 -0.4 -0.4 1.1 -1.0 -0.9 -1.0 -0.6 -0.3
Medication: Omeprazole 0.9 1.1 2.7 -1.1 -1.3 -0.7 -1.1 1.2 1.1 1.0 -0.7 -0.4 -0.6 -1.1 -0.7 -1.1 -0.9 -0.8 -0.7 -0.8 -1.0 -1.1 -1.1 -0.7 -0.9 -1.6 -1.1 -1.0 -0.9 1.2 -1.2 -1.2 -1.2 -1.2 -1.5
Medication: Seretide 50 evohaler 0.4 0.4 1.3 -0.7 -0.7 1.1 -0.4 1.0 0.9 1.0 -0.4 0.4 -0.7 -0.4 0.6 -0.6 -0.3 -0.3 -0.6 0.2 -0.6 -0.5 -0.5 -0.5 -0.7 0.2 -0.7 -0.4 -0.2 0.7 -1.0 -1.0 -0.9 -0.7 -0.5
Mean time to correctly identify matches 0.1 0.3 0.9 0.5 0.5 -0.1 1.0 -0.5 -0.3 -0.7 0.3 0.1 0.4 0.5 -0.6 0.5 0.1 0.3 0.5 0.3 0.4 0.5 0.7 0.6 0.4 0.9 0.6 0.4 0.4 -0.3 0.4 0.4 0.4 0.4 0.9
Heart disease (mother) 0.8 0.9 2.6 0.7 1.1 -1.1 0.7 -1.3 -1.4 -1.1 0.7 0.5 1.0 0.7 -0.1 0.8 0.8 0.4 0.3 -1.4 1.0 0.7 0.6 0.3 0.2 -1.6 0.7 0.4 0.3 -1.6 1.5 1.5 1.3 1.0 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 6.6 -0.3 -0.1 -1.5 -0.8 -0.2 -0.3 -0.2 -0.4 0.2 -0.0 -0.5 -0.2 -0.4 0.1 -0.6 -0.5 -0.5 -0.1 -1.1 -0.4 -0.6 -0.3 -2.6 -0.1 -0.6 -0.6 -0.8 0.3 0.3 0.1 -0.2 -1.0
Whole body fat mass 0.1 0.6 2.6 -0.7 -0.7 0.1 0.0 1.1 1.1 1.1 -0.7 0.1 -1.2 -0.5 0.4 -0.7 -0.2 -0.4 -0.2 -0.4 -1.2 -0.3 -0.5 0.0 0.0 -1.6 -0.8 -0.3 -0.1 0.9 -1.0 -1.1 -0.9 -1.0 -0.5
Leg fat mass (right) 0.1 0.4 1.5 -0.3 -0.3 0.7 0.5 1.0 1.0 1.1 -0.4 0.2 -1.2 -0.1 0.6 -0.3 0.1 0.0 0.3 0.5 -1.1 0.3 0.1 0.7 0.6 -1.0 -0.5 0.2 0.5 0.9 -0.8 -0.9 -0.6 -0.7 -0.1
Arm predicted mass (right) 1.2 6.1 12.2 -2.7 -2.4 -2.2 -1.8 2.0 1.9 1.8 -2.9 -2.2 -1.9 -2.8 0.1 -2.6 -2.4 -2.7 -2.8 -2.4 -2.4 -2.9 -2.7 -2.9 -2.8 -3.5 -2.5 -3.1 -3.2 1.4 -1.8 -1.9 -2.2 -2.4 -3.0
Pulse rate, automated reading 1.1 3.5 6.5 -1.8 -2.3 -1.0 -0.1 2.4 2.5 2.5 -1.5 -2.2 -1.2 -1.7 2.5 -1.9 -1.9 -1.3 -1.7 -1.1 -1.6 -1.9 -1.6 -1.5 -1.5 -0.4 -2.5 -1.6 -1.4 2.4 -2.3 -2.2 -2.2 -1.9 -2.0
Alcohol intake frequency. 2.7 6.3 10.8 2.7 2.6 1.3 3.0 -2.2 -2.2 -2.2 2.7 2.6 2.0 2.8 0.6 2.6 2.6 2.5 2.6 2.0 2.4 3.2 2.7 3.0 2.9 1.5 2.9 2.8 2.8 -2.2 2.2 2.2 2.4 2.4 3.3
Comparative height size at age 10 0.4 2.4 6.1 -1.5 -1.2 -1.9 -1.7 0.5 0.4 0.3 -1.4 -1.0 -0.1 -1.6 1.4 -1.4 -1.7 -1.6 -2.0 -2.3 -0.6 -1.9 -1.9 -2.4 -2.4 -2.5 -1.2 -2.1 -2.2 0.1 -0.5 -0.5 -0.8 -0.8 -1.8
Number of full sisters 0.1 0.1 0.4 -0.0 -0.0 0.4 -0.5 0.2 0.2 0.3 -0.1 0.3 -0.6 -0.0 0.1 -0.1 0.3 -0.1 0.2 0.3 -0.5 -0.0 0.0 0.4 0.3 -0.1 -0.1 0.1 0.2 0.4 -0.3 -0.3 -0.2 -0.4 0.1
Suffer from ‘nerves’ 0.5 0.8 1.8 0.8 0.9 0.9 -0.0 -1.4 -1.3 -1.3 0.8 -0.1 1.3 0.7 -0.4 0.8 1.1 0.7 0.7 -0.6 1.0 0.2 0.6 0.4 0.7 -0.2 0.8 0.4 0.3 -1.3 1.3 1.3 1.1 1.0 0.4
Overall health rating 0.3 0.7 3.6 -0.8 -0.7 -0.8 -0.7 0.7 0.7 0.4 -0.6 -1.9 -0.2 -0.9 1.0 -0.6 -0.6 -0.3 -0.6 -0.9 -0.7 -1.3 -0.8 -0.7 -0.7 -0.7 -0.8 -0.9 -0.9 1.2 -0.7 -0.7 -0.8 -0.8 -1.3
Chest pain or discomfort 0.2 0.4 0.9 0.6 0.5 0.7 0.7 -0.5 -0.5 -0.6 0.8 -0.9 0.6 0.7 0.4 0.6 1.0 0.6 0.7 0.3 0.4 0.5 0.6 0.6 0.6 -0.6 0.8 0.8 0.7 0.2 0.3 0.4 0.3 0.6 -0.2
Had major operations 0.8 1.0 3.5 -1.0 -1.0 -1.2 -0.6 1.2 1.2 1.1 -1.0 -1.9 -1.1 -0.9 0.1 -1.0 -1.1 -0.9 -1.2 -0.4 -0.9 -0.9 -0.9 -0.9 -0.8 0.6 -1.1 -0.8 -0.8 1.1 -1.1 -1.1 -1.0 -1.0 -0.1
Age at last live birth 1.1 1.6 3.4 -1.4 -1.1 -1.8 -1.5 0.6 0.5 0.6 -1.4 -1.0 -1.1 -1.6 0.9 -1.4 -1.1 -1.2 -1.4 -1.7 -1.0 -1.8 -1.4 -1.8 -1.4 -1.5 -1.0 -1.6 -1.6 0.0 -0.5 -0.5 -0.7 -1.0 -1.7
Family relationship satisfaction 1.5 1.9 6.4 -1.6 -1.0 -1.2 -2.5 1.0 0.7 1.0 -1.6 -1.3 -1.6 -1.4 -1.8 -1.4 -0.8 -1.3 -1.5 -1.9 -1.6 -1.5 -1.5 -1.3 -1.5 -1.8 -1.0 -1.5 -1.5 1.0 -0.7 -0.9 -0.9 -1.3 -1.2
Leg pain on walking 0.1 0.1 0.8 0.2 0.3 0.1 0.9 -0.1 -0.2 -0.2 -0.1 -0.6 -0.2 0.2 -0.5 0.2 0.1 0.1 0.2 0.5 -0.1 0.1 0.3 0.1 0.1 -0.1 0.2 0.1 0.1 -0.6 0.2 0.2 0.2 0.3 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.6 -0.5 -0.9 0.6 0.3 1.1 1.2 1.2 -0.3 0.9 -0.6 -0.4 0.2 -0.6 -0.3 -0.2 -0.3 0.5 -0.7 -0.2 -0.5 -0.1 -0.2 0.8 -0.7 -0.2 -0.1 1.2 -1.2 -1.2 -1.0 -0.8 -0.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.9 -0.1 0.0 -0.9 -0.8 -0.3 -0.0 -0.5 -0.1 -0.4 0.2 -0.1 -0.9 0.1 -0.3 -0.4 -0.2 -0.3 0.0 -0.4 -0.2 -0.4 -0.3 -0.1 0.4 -0.2 -0.3 0.1 -0.1 -0.1 -0.1 0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 2.9 3.6 5.6 2.1 1.8 1.0 2.2 -1.6 -1.5 -1.6 2.3 2.3 2.3 2.2 0.1 2.2 1.4 2.0 1.9 1.5 2.4 2.4 2.1 2.1 2.0 1.7 1.9 2.1 2.0 -1.6 1.5 1.6 1.6 2.0 2.0
Medication: Aspirin 0.6 0.8 3.0 -0.7 -0.9 -0.6 -0.7 1.4 1.4 1.3 -0.7 0.2 -0.8 -0.6 0.8 -0.6 -1.2 -0.6 -0.8 0.9 -0.9 -0.6 -0.5 -0.5 -0.5 1.0 -0.8 -0.6 -0.5 1.7 -1.3 -1.3 -1.1 -0.9 -0.4
Supplements: Vitamin C 0.2 0.3 2.9 -0.0 0.3 -1.4 -0.7 -0.5 -0.5 -0.2 0.1 -0.3 0.2 0.0 0.2 0.0 0.5 0.3 -0.2 -1.7 0.4 -0.2 -0.1 -0.1 0.2 -0.5 0.1 0.0 0.1 -0.7 0.6 0.6 0.5 0.4 -0.2
Knee pain experienced in last month 1.8 2.8 8.7 1.8 1.4 2.0 2.9 -0.7 -0.8 -0.9 1.9 1.1 1.6 1.9 2.9 1.8 1.3 1.5 1.7 2.3 1.5 2.1 1.8 1.8 1.7 2.0 1.4 1.8 1.8 -0.6 0.8 0.9 1.0 1.5 1.9
Hypertension (Self-reported) 0.0 0.1 1.1 0.2 -0.0 -0.3 1.0 -0.0 0.0 -0.2 0.3 0.3 0.7 0.0 0.8 0.2 -0.4 0.1 0.3 0.2 0.5 0.1 0.2 0.3 0.4 0.8 -0.3 0.1 0.0 0.2 0.0 0.1 -0.0 0.0 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 2.7 -1.5 -1.3 -0.2 -1.3 1.1 1.1 0.8 -1.4 0.5 -1.2 -1.4 -1.4 -1.4 -1.4 -1.5 -1.4 -1.1 -1.4 -1.5 -1.3 -1.6 -1.5 -0.6 -0.9 -1.5 -1.5 0.7 -1.2 -1.3 -1.3 -1.4 -0.5
Illnesses of father: Heart disease 0.5 0.7 3.1 -0.9 -0.8 -0.1 -0.2 0.7 0.9 0.6 -0.9 -1.4 -0.8 -0.9 1.8 -0.9 -0.7 -0.9 -0.9 -0.5 -0.8 -0.8 -0.8 -0.9 -1.1 0.4 -0.8 -0.9 -1.0 0.9 -0.8 -0.8 -0.8 -0.9 -0.5
Illnesses of siblings: Diabetes 1.2 1.4 3.2 1.1 1.3 1.5 1.2 -0.8 -1.0 -0.7 1.0 0.7 0.4 1.3 0.9 1.1 1.5 1.4 1.5 0.5 0.9 1.3 1.3 1.5 1.4 1.6 1.4 1.3 1.4 -0.6 1.0 1.0 1.2 1.1 1.8
Smoking status: Previous 0.7 1.0 5.8 1.0 0.9 2.4 1.4 -0.7 -0.9 -0.7 1.0 0.9 1.0 0.9 0.5 1.0 0.8 1.2 1.1 1.1 1.0 0.4 1.1 0.8 1.0 0.6 0.7 0.7 0.7 -0.8 0.9 1.0 0.9 0.9 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 4.9 -0.1 -0.1 -1.3 -0.2 -0.3 -0.4 -0.4 -0.2 -0.6 0.6 -0.4 -0.5 -0.1 0.1 -0.6 -0.9 -0.3 0.1 -0.7 -0.6 -1.0 -0.8 -2.2 -0.4 -0.7 -0.9 -0.6 0.4 0.4 0.1 0.0 -0.8
Whole body fat-free mass 1.4 8.0 14.5 -3.0 -2.9 -2.6 -2.2 2.4 2.3 2.1 -3.2 -2.2 -2.2 -3.2 -0.4 -3.0 -2.8 -3.2 -3.2 -2.4 -2.7 -3.2 -3.2 -3.3 -3.2 -3.8 -2.9 -3.4 -3.5 1.6 -2.2 -2.4 -2.7 -2.8 -3.7
Leg fat-free mass (right) 1.0 5.4 15.4 -2.4 -2.4 -2.3 -1.8 1.8 1.8 1.4 -2.5 -1.4 -1.6 -2.6 -0.8 -2.4 -2.1 -2.8 -2.5 -2.0 -2.2 -2.8 -2.6 -2.6 -2.5 -3.9 -2.2 -2.7 -2.9 1.2 -1.8 -1.9 -2.3 -2.3 -3.3
Arm fat percentage (left) 0.2 0.6 2.2 0.4 0.2 1.3 1.0 0.5 0.5 0.6 0.3 1.3 -0.8 0.6 -0.1 0.3 0.8 0.5 1.1 1.0 -0.7 0.9 0.8 1.5 1.4 -0.4 0.2 1.1 1.3 0.6 -0.4 -0.5 -0.2 -0.2 0.6
Average weekly red wine intake 0.9 1.3 4.1 -1.3 -1.1 -0.2 -0.9 0.9 0.7 0.8 -1.1 -2.0 -0.7 -1.3 0.9 -1.2 -0.9 -0.8 -1.1 -2.0 -0.8 -1.6 -1.5 -1.5 -1.4 -0.6 -1.1 -1.3 -1.4 0.8 -0.8 -0.8 -0.9 -1.0 -1.3
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.7 1.0 1.2 0.6 0.1 -1.3 -1.2 -1.2 0.8 1.1 0.8 0.9 -0.8 1.0 1.1 0.7 0.8 0.1 1.1 0.7 0.9 0.8 0.8 0.8 1.1 0.8 0.7 -1.1 1.3 1.2 1.2 1.1 1.1
Mood swings 0.1 0.2 2.1 0.3 0.4 1.4 0.4 -0.1 -0.3 0.1 0.2 -0.8 -0.2 0.3 0.4 0.3 0.9 0.7 0.4 0.3 -0.1 0.2 0.4 0.3 0.4 -0.3 0.2 0.4 0.5 -0.2 0.3 0.3 0.3 0.2 0.0
Loneliness, isolation 0.2 0.3 3.9 -0.4 -0.2 -0.4 0.5 -0.1 -0.3 -0.2 -0.3 -0.8 -0.2 -0.4 -1.1 -0.4 0.2 -0.2 -0.2 -1.2 -0.2 -0.5 -0.2 -0.3 -0.0 -2.0 -0.1 -0.3 -0.4 -0.2 0.3 0.2 0.0 -0.2 -0.9
Long-standing illness, disability or infirmity 0.2 0.3 1.1 -0.3 -0.4 0.1 0.2 1.0 0.9 1.1 -0.3 -0.6 -0.7 -0.2 0.3 -0.3 -0.3 -0.4 -0.1 0.6 -0.7 -0.1 -0.1 0.1 0.3 -0.1 -0.7 0.0 0.1 0.8 -0.8 -0.8 -0.7 -0.6 -0.5
Ever had bowel cancer screening 6.8 8.0 12.1 3.1 2.9 2.8 2.4 -2.4 -2.4 -2.0 3.2 3.0 2.3 3.2 1.5 3.0 3.1 3.5 3.4 2.3 2.7 3.1 3.3 3.4 3.1 2.1 3.1 3.4 3.5 -1.7 2.4 2.5 2.7 2.9 2.8
Diabetes diagnosed by doctor 0.2 0.4 1.5 -0.2 -0.4 -0.5 0.2 0.9 0.9 1.1 -0.4 -0.2 -0.6 -0.3 1.2 -0.2 -0.6 -0.4 -0.3 0.9 -0.9 -0.4 -0.1 -0.1 -0.2 0.3 -0.8 -0.2 -0.1 0.7 -0.8 -0.7 -0.7 -0.6 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.8 0.7 0.9 0.6 0.4 -0.7 -0.7 -0.7 0.7 -0.2 0.6 0.8 0.6 0.8 0.7 0.9 0.7 0.3 0.7 0.6 0.7 0.7 0.8 0.7 0.8 0.6 0.6 -0.4 0.7 0.7 0.8 0.8 0.8
Friendships satisfaction 1.2 1.5 4.1 -1.3 -0.9 -0.4 -2.0 1.0 0.6 1.2 -1.4 -1.7 -1.4 -1.3 -1.9 -1.3 -0.5 -0.9 -1.3 -1.5 -1.4 -1.0 -1.3 -1.2 -1.5 -1.4 -1.2 -1.3 -1.2 0.9 -0.6 -0.6 -0.8 -1.1 -1.6
Qualifications: nursing, teaching 0.1 0.2 2.0 -0.0 0.5 0.4 -0.2 -0.2 -0.5 0.0 -0.2 -1.4 -0.5 0.1 -0.3 0.1 0.5 0.2 0.2 -0.7 -0.1 0.5 0.2 0.1 0.3 -1.0 0.2 0.2 0.3 -0.9 0.4 0.4 0.5 0.3 0.3
Commuting to job workplace: Walk 0.1 0.1 0.5 -0.1 -0.2 0.6 0.3 0.4 0.2 0.6 -0.1 0.2 -0.6 -0.1 -0.2 -0.3 0.1 0.4 0.2 0.0 -0.2 0.3 0.2 0.4 0.5 0.7 -0.3 0.2 0.3 0.1 -0.1 -0.1 -0.0 -0.2 0.0
Eye problems/disorders: Cataract 2.7 3.2 5.6 1.9 1.8 0.5 2.4 -1.3 -1.4 -1.1 2.0 1.9 1.5 2.1 1.1 2.0 1.6 2.2 2.0 1.5 1.9 2.3 1.7 2.2 2.0 2.0 1.5 2.0 2.1 -1.3 1.4 1.5 1.7 1.8 2.0
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 6.2 1.4 1.3 2.5 2.1 -0.7 -0.9 -0.5 1.5 1.5 0.6 1.7 -0.2 1.4 1.3 1.8 1.7 1.4 1.1 2.1 1.6 2.0 2.0 2.2 1.4 1.8 1.9 -0.9 0.8 0.8 1.2 1.2 2.5
Medication for cholesterol 0.9 1.3 3.8 -1.1 -1.3 0.9 -0.0 1.7 1.6 1.8 -1.2 0.8 -1.9 -1.1 0.4 -1.3 -0.7 -0.7 -0.6 0.6 -1.6 -0.2 -0.7 -0.3 -0.3 0.1 -1.0 -0.7 -0.6 1.7 -1.6 -1.7 -1.5 -1.6 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 6.2 -0.1 -0.2 0.8 0.5 0.4 0.3 0.1 0.2 -0.5 -0.1 0.0 2.5 -0.1 0.0 0.5 0.4 0.2 0.3 0.1 -0.0 0.2 0.4 0.7 0.3 0.3 0.3 0.8 -0.3 -0.3 -0.2 -0.1 -0.6
Back pain experienced in last month 0.2 0.2 1.5 0.1 -0.0 0.3 -0.2 0.2 0.2 0.0 0.4 1.2 -0.3 0.3 0.1 0.1 0.4 0.3 0.6 0.6 -0.2 0.5 0.2 0.7 0.8 0.9 0.4 0.7 0.7 1.0 -0.3 -0.3 -0.2 -0.1 0.0
Mineral and other dietary supplements 0.2 0.3 1.9 0.3 0.2 1.4 0.2 -0.0 0.1 -0.0 0.3 -0.4 -0.1 0.4 -1.0 0.3 0.5 0.5 0.6 0.7 0.0 0.6 0.4 0.6 0.5 1.0 0.1 0.6 0.7 0.1 -0.1 -0.0 0.2 0.2 0.8
Breast cancer (self-reported) 5.0 6.0 12.2 -2.6 -2.8 -1.4 -1.0 3.3 3.3 3.3 -2.6 -1.3 -3.2 -2.2 0.4 -2.6 -2.9 -2.4 -2.4 -0.0 -3.1 -1.9 -2.1 -1.9 -1.8 0.3 -2.6 -2.0 -1.8 3.5 -3.3 -3.3 -3.0 -2.8 -1.8
Asthma (self-reported) 0.9 1.8 3.4 1.4 1.5 0.3 0.8 -1.5 -1.8 -1.4 1.7 0.6 1.7 1.4 -0.5 1.5 1.8 1.7 1.3 -0.5 1.8 1.3 1.2 1.1 1.1 -0.4 1.4 1.3 1.3 -1.4 1.7 1.7 1.6 1.5 0.5
Osteoporosis (self-reported) 0.5 0.6 8.3 -0.0 -0.1 -2.9 -1.1 -0.2 -0.3 -0.4 0.0 -0.8 0.2 -0.0 -0.8 -0.1 -0.2 -0.3 -0.4 -0.6 0.0 -0.1 -0.3 -0.2 -0.0 -2.5 0.3 -0.0 -0.1 -0.2 0.1 0.2 0.1 0.3 -0.7
Osteoarthritis (self-reported) 1.9 2.5 5.9 1.6 1.4 0.9 2.3 -1.3 -1.3 -1.5 2.0 2.4 2.0 1.6 0.9 1.8 1.1 1.8 1.6 1.3 2.2 1.5 1.4 1.5 1.5 2.4 1.3 1.6 1.6 -1.2 1.1 1.2 1.2 1.5 1.3
Medication: Aspirin 0.3 0.4 2.2 -0.2 -0.5 0.3 -0.0 1.1 1.1 0.9 -0.1 0.2 -0.3 -0.1 1.2 -0.1 -0.7 -0.1 -0.2 1.3 -0.5 -0.1 -0.0 0.0 -0.0 1.1 -0.4 -0.1 -0.0 1.5 -1.0 -0.9 -0.8 -0.5 0.0
Medication: Gliclazide 1.6 1.8 4.0 -1.2 -1.3 -1.0 -1.2 1.8 1.8 2.0 -1.3 0.3 -1.6 -1.2 -0.5 -1.2 -1.4 -1.5 -1.3 0.3 -1.7 -0.9 -1.1 -0.9 -1.1 0.1 -1.7 -1.0 -0.8 1.9 -1.7 -1.7 -1.6 -1.6 -1.0
Illnesses of father: None of the above (group 1) 0.2 0.2 2.9 -0.2 -0.2 1.1 -0.7 0.0 0.0 -0.2 -0.0 -1.7 0.1 -0.3 0.8 -0.1 0.0 -0.1 0.1 0.0 -0.3 -0.2 -0.3 -0.3 -0.4 -0.7 0.2 -0.2 -0.2 0.4 -0.1 -0.1 -0.1 -0.0 -0.7
Smoking status: Current 0.9 1.5 11.9 -1.1 -1.0 -0.9 -0.8 1.4 1.5 1.3 -1.0 -3.4 -1.4 -0.8 1.3 -1.0 -1.2 -0.6 -0.6 -0.3 -1.4 -0.5 -0.7 -0.5 -0.5 1.1 -0.9 -0.6 -0.4 2.0 -1.5 -1.5 -1.2 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 -0.8 -1.1 -0.6 0.3 0.5 0.8 0.3 -0.6 -1.3 0.3 -1.0 1.1 -0.8 -1.0 -0.8 -0.8 -1.1 -0.4 -1.0 -1.1 -1.0 -1.0 -1.1 -1.0 -1.1 -1.2 0.7 -0.9 -0.8 -1.0 -0.8 -1.4
Whole body water mass 1.3 7.7 13.2 -3.0 -2.8 -2.5 -2.1 2.4 2.3 2.1 -3.1 -2.1 -2.2 -3.2 -0.3 -3.0 -2.7 -3.2 -3.1 -2.3 -2.7 -3.2 -3.1 -3.2 -3.2 -3.6 -2.9 -3.4 -3.5 1.7 -2.2 -2.3 -2.6 -2.8 -3.6
Leg predicted mass (right) 1.0 5.2 15.3 -2.3 -2.3 -2.3 -1.8 1.7 1.8 1.3 -2.5 -1.3 -1.6 -2.6 -0.9 -2.4 -2.0 -2.8 -2.5 -1.9 -2.1 -2.8 -2.6 -2.6 -2.5 -3.9 -2.2 -2.7 -2.9 1.1 -1.7 -1.8 -2.2 -2.3 -3.3
Arm fat mass (left) 0.1 0.4 1.6 -0.4 -0.5 0.3 0.4 0.9 0.9 0.9 -0.5 0.6 -1.1 -0.3 0.1 -0.4 0.0 -0.2 0.1 0.2 -1.1 -0.1 -0.1 0.5 0.5 -1.3 -0.5 0.0 0.2 0.8 -0.8 -0.9 -0.7 -0.8 -0.4
Number of self-reported non-cancer illnesses 1.0 1.8 2.9 1.5 1.3 0.8 1.0 -1.2 -1.3 -1.2 1.7 1.5 1.6 1.4 -1.1 1.5 1.7 1.6 1.7 0.7 1.5 1.4 1.3 1.7 1.6 -0.2 1.2 1.5 1.6 -1.1 1.2 1.3 1.2 1.3 0.6
Average weekly champagne plus white wine intake 0.3 0.4 1.4 0.5 0.4 0.5 0.7 -0.6 -0.5 -0.7 0.7 0.5 0.9 0.6 -0.2 0.6 0.3 0.7 0.6 -0.4 1.0 0.7 0.4 0.5 0.8 1.2 0.6 0.6 0.6 -0.4 0.4 0.5 0.4 0.4 0.9
Miserableness 0.2 0.4 3.3 -0.1 -0.1 1.1 0.8 0.6 0.4 0.7 -0.3 -1.4 -0.9 0.0 1.0 -0.2 0.2 0.6 0.5 0.7 -0.7 0.4 0.4 0.6 0.6 1.8 -0.3 0.2 0.3 0.5 -0.3 -0.4 -0.2 -0.3 0.3
Guilty feelings 0.4 0.6 2.4 -0.9 -0.8 -0.2 -0.3 0.6 0.4 0.6 -0.8 -1.6 -0.7 -0.9 -0.9 -1.0 -0.5 -0.5 -0.7 -1.2 -0.7 -1.0 -0.8 -0.8 -0.7 -0.5 -0.6 -0.9 -0.9 0.1 -0.4 -0.5 -0.5 -0.7 -1.0
Wears glasses or contact lenses 0.5 0.6 1.2 0.8 0.7 0.1 0.4 -0.7 -0.6 -0.6 1.0 -0.9 0.9 1.0 0.3 0.9 0.8 1.1 0.8 -0.2 0.9 0.8 0.8 1.0 1.0 0.8 0.8 1.0 1.1 -0.3 0.6 0.7 0.7 0.9 0.7
Ever taken oral contraceptive pill 0.2 0.2 1.9 -0.2 0.0 1.4 -0.7 -0.3 -0.3 -0.4 -0.2 -0.8 0.0 -0.4 -0.3 -0.1 0.4 -0.0 -0.1 -0.6 -0.3 -0.5 -0.4 -0.5 -0.5 0.1 0.1 -0.4 -0.5 -0.1 0.2 0.1 0.0 -0.1 -0.2
Hearing aid user 0.9 1.0 3.3 1.0 1.2 1.3 1.1 -0.5 -0.8 -0.4 0.8 0.6 0.3 1.2 0.5 1.0 0.9 0.8 1.0 1.4 0.5 1.5 1.2 1.2 0.9 1.1 1.0 1.0 1.1 -0.9 0.8 0.8 1.1 1.0 1.8
Mother’s age at death 0.9 1.1 2.6 1.1 1.1 1.6 0.6 -0.8 -1.0 -0.5 1.1 -0.2 0.8 1.2 0.3 1.1 1.3 0.7 1.1 0.7 0.6 1.3 1.2 1.2 1.2 -0.8 0.9 1.3 1.3 -1.4 1.1 1.1 1.2 1.2 0.6
Financial situation satisfaction 5.6 7.0 10.4 -2.8 -2.8 -0.9 -2.6 2.9 2.7 2.7 -2.8 -2.0 -2.7 -2.9 -0.6 -2.8 -2.3 -2.9 -2.8 -0.9 -3.2 -3.0 -2.7 -2.7 -2.7 -2.3 -2.9 -2.8 -2.7 2.7 -2.7 -2.8 -2.9 -3.0 -2.8
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.8 0.9 0.8 0.4 0.8 -0.5 -0.5 -0.4 0.6 1.6 -0.2 0.9 -0.6 0.7 0.7 1.0 1.1 1.2 0.4 1.0 1.1 1.2 1.4 1.7 1.0 1.2 1.2 -0.5 0.7 0.5 0.7 0.6 1.0
Commuting to job workplace: Public transport 4.2 5.0 7.1 -2.5 -2.6 -0.7 -0.6 2.5 2.2 2.6 -2.4 -0.9 -2.1 -2.5 2.1 -2.6 -2.3 -2.1 -2.5 -1.3 -2.0 -1.9 -2.5 -2.5 -2.4 -1.5 -2.7 -2.5 -2.5 2.1 -2.3 -2.2 -2.4 -2.5 -2.6
Eye problems/disorders: Glaucoma 0.3 0.3 2.9 0.3 0.3 -0.8 1.4 -0.0 -0.0 0.5 0.1 0.5 0.1 0.3 1.7 0.2 -0.3 0.5 0.1 0.2 0.4 0.4 0.5 0.2 0.4 1.5 -0.1 0.2 0.2 -0.5 0.2 0.2 0.3 0.4 0.3
Medication: Blood pressure 0.2 0.3 1.5 0.4 0.4 -1.2 -0.2 -0.7 -0.7 -0.8 0.4 0.5 1.2 0.2 -0.2 0.4 -0.1 -0.0 -0.1 -0.7 0.9 -0.6 0.1 -0.2 -0.1 -0.3 -0.0 -0.1 -0.1 -1.1 0.8 0.9 0.6 0.5 0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 9.0 0.3 0.3 0.5 0.9 -0.3 -0.2 -0.4 0.2 -0.4 0.3 0.2 3.0 0.3 0.5 1.2 0.6 0.4 0.4 0.1 0.4 0.4 0.6 2.1 0.2 0.2 0.2 0.3 0.2 0.3 0.2 0.2 -0.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.3 -0.2 0.1 -1.1 0.3 -0.2 -0.4 -0.0 -0.3 0.2 0.3 -0.2 1.1 -0.1 -0.5 -0.1 -0.5 -1.1 0.2 -0.3 -0.2 -0.6 -0.6 -0.7 -0.1 -0.6 -0.7 -0.7 0.4 0.3 0.2 0.0 -0.2
High cholesterol (Self-reported) 1.4 2.5 4.9 1.7 1.8 0.9 1.9 -1.6 -1.7 -1.6 1.6 0.7 1.8 1.7 0.0 1.8 1.2 1.7 1.5 0.5 1.9 1.4 1.6 1.4 1.2 2.2 1.4 1.4 1.3 -1.8 1.7 1.7 1.7 1.7 2.2
Medication: Bendroflumethiazide 1.5 2.3 4.2 1.7 1.6 2.1 1.1 -1.6 -1.5 -1.6 1.7 1.1 1.9 1.7 0.1 1.7 1.4 1.2 1.6 1.6 1.7 1.4 1.7 1.5 1.4 0.7 1.3 1.4 1.4 -1.3 1.5 1.6 1.5 1.7 1.8
Medication: Paracetamol 0.7 1.0 3.3 1.1 0.7 1.5 1.7 -0.6 -0.5 -0.6 1.0 0.9 1.1 1.0 1.8 1.0 1.1 1.0 0.9 1.6 1.0 0.9 1.0 0.9 1.1 1.3 0.6 0.8 0.7 -0.7 0.6 0.7 0.5 0.7 0.5
Medication: Lisinopril 0.9 1.1 2.7 -0.9 -0.8 -1.1 -1.6 1.1 1.0 1.3 -1.2 1.1 -1.1 -1.1 -0.9 -0.9 -1.0 -1.2 -1.2 0.6 -1.4 -1.2 -0.9 -1.0 -1.2 0.2 -1.5 -1.1 -1.1 0.8 -0.8 -0.8 -0.9 -1.0 -1.0
Medication: Atorvastatin 0.3 0.4 1.9 0.6 0.7 0.2 0.9 -0.4 -0.4 -0.4 0.5 0.2 0.2 0.7 0.4 0.7 0.4 0.9 0.6 0.4 0.3 0.6 0.7 0.7 0.5 1.4 0.8 0.7 0.6 -0.5 0.5 0.5 0.5 0.4 1.1
Illnesses of father: High blood pressure 0.3 0.3 5.9 0.0 -0.1 -1.6 0.3 -0.1 -0.2 -0.0 0.3 2.4 0.6 0.0 -0.1 0.1 -0.4 0.1 -0.2 -1.0 0.9 -0.0 -0.1 0.0 0.1 0.3 -0.3 -0.1 -0.1 -0.1 0.0 0.2 0.0 0.1 -0.0
Alcohol drinker status: Never 4.1 5.0 10.1 2.4 2.4 2.1 1.4 -1.6 -1.7 -1.7 2.5 2.0 1.9 2.7 -0.4 2.5 2.1 2.3 2.3 2.7 2.1 3.2 2.3 2.5 2.5 2.2 2.3 2.6 2.7 -1.7 1.7 1.7 2.1 2.4 2.8
Ever smoked 0.2 0.3 3.4 -0.1 -0.4 1.1 -0.0 0.7 0.6 0.6 -0.1 -1.9 -0.1 -0.1 0.7 -0.2 -0.4 0.2 0.1 1.0 -0.5 -0.2 0.1 -0.1 -0.0 -0.2 -0.3 -0.1 -0.0 1.1 -0.6 -0.5 -0.5 -0.2 -0.8
Basal metabolic rate 1.1 6.2 12.5 -2.7 -2.5 -2.2 -1.9 2.2 2.1 1.9 -2.8 -1.8 -2.0 -2.8 -0.3 -2.7 -2.4 -2.9 -2.7 -2.1 -2.5 -2.8 -2.8 -2.8 -2.8 -3.5 -2.6 -3.0 -3.0 1.6 -2.1 -2.2 -2.4 -2.6 -3.2
Leg fat percentage (left) 0.2 0.8 3.0 0.4 0.2 1.7 1.1 0.8 0.7 0.8 0.2 0.8 -1.0 0.6 0.8 0.3 0.6 0.7 1.0 1.5 -0.9 0.9 0.8 1.4 1.3 0.0 0.0 1.0 1.2 0.9 -0.6 -0.6 -0.3 -0.3 0.8
Arm fat-free mass (left) 1.0 4.9 8.5 -2.4 -2.2 -1.8 -1.7 1.9 1.8 1.6 -2.6 -1.9 -1.7 -2.5 -0.2 -2.4 -2.2 -2.4 -2.4 -2.1 -2.2 -2.6 -2.5 -2.5 -2.5 -2.9 -2.3 -2.8 -2.8 1.4 -1.7 -1.8 -2.1 -2.2 -2.8
Number of operations (self-reported) 1.5 2.2 3.7 -1.7 -1.5 -0.9 -1.8 1.4 1.4 1.2 -1.8 -1.3 -1.9 -1.6 -1.0 -1.6 -1.5 -1.2 -1.5 -1.2 -1.7 -1.4 -1.8 -1.5 -1.5 -0.2 -1.2 -1.5 -1.5 1.6 -1.6 -1.6 -1.6 -1.7 -1.0
Average weekly beer plus cider intake 0.2 0.2 3.2 -0.1 -0.2 -0.9 0.4 -0.0 -0.0 -0.3 -0.1 -1.8 0.2 -0.2 -0.4 -0.1 -0.1 -0.4 -0.3 0.1 0.0 -0.2 -0.2 -0.3 -0.1 -1.4 0.1 -0.3 -0.4 -0.0 0.1 -0.0 -0.2 -0.1 -0.7
Irritability 0.3 0.5 3.4 -0.1 -0.5 1.8 1.0 0.8 0.8 0.8 -0.0 -0.3 -0.2 -0.0 1.1 -0.2 -0.1 0.2 0.2 1.1 -0.3 -0.2 0.2 0.1 0.3 1.8 -0.3 0.0 0.1 0.9 -0.8 -0.7 -0.7 -0.4 0.0
Risk taking 1.7 2.5 4.6 -1.6 -1.7 -0.2 -1.6 1.8 1.8 1.6 -1.4 -0.9 -1.4 -1.6 0.4 -1.5 -1.6 -1.5 -1.4 -0.4 -1.9 -1.5 -1.8 -1.5 -1.5 -2.1 -1.4 -1.5 -1.4 1.8 -1.9 -1.9 -1.9 -1.8 -2.1
Ever had prostate specific antigen (PSA) test 2.4 2.8 5.5 1.5 1.7 2.1 2.1 -1.2 -1.5 -0.9 1.8 -0.3 1.2 1.8 1.4 1.7 1.9 2.3 1.8 0.1 1.7 1.7 1.7 1.8 1.9 0.8 1.5 1.9 2.0 -1.6 1.6 1.6 1.8 1.7 1.9
Fractured/broken bones in last 5 years 1.4 1.9 8.5 -1.3 -0.9 -2.9 -2.5 0.8 0.7 0.9 -1.4 0.0 -1.0 -1.3 -0.3 -1.2 -1.0 -1.5 -1.8 -1.8 -1.0 -1.3 -1.6 -1.5 -1.0 -2.3 -1.1 -1.5 -1.5 0.3 -0.6 -0.7 -0.8 -1.1 -1.4
Age started oral contraceptive pill 1.6 2.0 3.5 1.4 1.6 0.8 0.9 -1.9 -1.8 -1.9 1.4 1.7 1.5 1.3 -1.0 1.5 1.4 1.5 1.5 -0.5 1.7 1.3 1.3 1.2 1.1 0.2 1.8 1.3 1.2 -1.6 1.7 1.7 1.7 1.5 1.4
Diastolic blood pressure, automated reading 0.1 0.4 1.3 -0.2 -0.5 -0.6 0.8 1.0 1.1 1.0 -0.2 0.4 -0.6 0.0 -0.2 -0.3 -0.7 -0.5 0.1 0.7 -0.7 0.2 0.1 0.5 0.5 0.4 -0.6 0.2 0.3 0.7 -1.0 -1.0 -0.8 -0.5 0.1
Ever depressed for a whole week 0.4 0.5 1.4 -0.8 -0.6 -1.2 0.0 0.7 0.6 0.9 -0.9 -1.1 -0.5 -0.8 0.7 -0.7 -0.7 -0.5 -0.8 -0.7 -0.5 -1.0 -0.7 -0.7 -0.4 -0.5 -1.1 -0.9 -0.8 0.1 -0.4 -0.4 -0.5 -0.5 -1.0
Unable to work because of sickness or disability 0.3 0.3 0.9 -0.4 -0.5 -0.8 -0.9 0.8 0.6 0.6 -0.3 0.7 -0.3 -0.3 -0.5 -0.3 -0.4 -0.6 -0.8 0.9 -0.5 -0.5 -0.5 -0.6 -0.4 -0.7 -0.6 -0.5 -0.4 0.5 -0.6 -0.6 -0.6 -0.5 -0.4
Commuting to job workplace: Cycle 0.4 0.5 2.6 0.5 0.6 0.9 -0.4 -1.0 -0.9 -1.0 0.7 0.2 0.8 0.5 0.8 0.5 0.9 0.2 0.5 -0.7 0.7 0.3 0.2 0.2 0.4 -1.6 1.0 0.4 0.4 -0.9 0.8 0.8 0.7 0.6 0.3
Myopia 0.3 0.4 9.2 0.0 0.2 -0.4 -0.5 -0.2 -0.1 -0.2 0.2 0.7 0.1 0.2 -3.0 0.2 0.2 -0.2 0.1 -0.5 -0.0 0.2 0.2 0.2 -0.1 -1.1 -0.0 0.3 0.4 -0.1 0.0 0.1 0.1 0.1 0.4
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.6 -0.1 0.2 0.7 -0.8 -0.1 -0.1 0.2 -0.2 -0.2 -0.6 0.2 -0.6 -0.1 0.6 0.2 -0.0 -0.3 -0.4 0.2 -0.0 -0.0 -0.1 -0.3 0.4 0.1 0.2 -0.3 0.1 -0.0 0.2 0.1 0.2
Cholesterol lowering medication 0.6 0.9 2.7 0.9 1.0 -0.2 0.2 -1.4 -1.3 -1.5 0.9 0.6 1.6 0.8 -1.6 1.1 0.6 0.4 0.4 -0.2 1.2 0.0 0.6 0.1 0.1 -0.5 0.6 0.3 0.2 -1.4 1.2 1.3 1.0 1.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.7 -0.8 -1.1 -0.2 -1.1 0.9 1.0 0.8 -0.5 0.3 -0.3 -0.9 -1.3 -0.8 -0.5 -0.5 -0.4 -0.3 -0.8 -0.9 -0.9 -0.3 -0.5 -1.0 -1.0 -0.7 -0.6 1.1 -1.1 -1.0 -1.1 -1.0 -1.3
Pain experienced in last month 1.8 3.0 19.8 -1.5 -1.0 -2.2 -2.3 0.3 0.3 0.2 -1.7 -1.2 -0.9 -1.6 -4.5 -1.4 -1.3 -2.1 -1.9 -2.3 -1.1 -1.9 -1.7 -2.2 -2.3 -3.0 -0.9 -1.9 -2.0 -0.1 -0.3 -0.4 -0.6 -0.9 -1.2
Supplements: Calcium 1.6 1.7 14.3 -1.1 -1.0 -3.8 -1.2 0.6 0.7 0.5 -1.2 0.0 -0.5 -1.1 -1.5 -1.0 -1.4 -1.5 -1.7 -1.1 -0.9 -1.4 -1.4 -1.6 -1.3 -1.8 -0.8 -1.5 -1.6 0.5 -0.8 -0.7 -0.9 -0.8 -1.2
Basal cell carcinoma (self-reported) 34.0 40.4 58.1 -7.3 -7.1 -2.5 -6.1 7.1 7.2 7.1 -7.1 -3.0 -7.6 -7.0 -1.8 -7.3 -6.7 -6.5 -6.2 -3.5 -7.4 -6.3 -6.7 -6.0 -6.2 -0.5 -6.9 -6.3 -6.0 7.3 -7.3 -7.4 -7.1 -7.3 -5.5
Heart attack/myocardial infarction (self-reported) 2.2 2.9 5.1 -1.6 -1.8 -1.4 -1.4 1.7 1.6 1.3 -1.6 -1.9 -0.9 -1.8 0.4 -1.5 -2.0 -1.9 -2.0 0.2 -1.7 -2.3 -1.7 -2.0 -2.0 -0.5 -1.8 -1.9 -2.0 2.0 -1.7 -1.6 -2.0 -1.7 -2.1
Deep venous thrombosis (DVT) (self-reported) 4.1 5.2 7.7 2.5 2.4 1.6 2.8 -2.5 -2.4 -2.6 2.5 0.8 2.7 2.6 -0.3 2.5 2.3 2.3 2.3 1.5 2.5 2.1 2.4 2.1 2.1 0.8 2.7 2.2 2.2 -2.6 2.4 2.4 2.4 2.6 2.6
Heart disease (siblings) 0.9 1.1 4.3 1.1 0.9 1.7 0.3 -0.8 -0.9 -0.9 1.6 1.4 1.8 1.0 2.1 1.2 1.1 1.0 1.1 0.6 1.5 0.6 0.7 1.0 0.8 0.2 0.7 1.0 1.1 -0.7 0.7 0.9 0.8 1.0 0.8
Alcohol drinker status: Previous 1.0 1.1 2.2 1.2 1.1 0.8 1.5 -1.1 -1.1 -1.0 0.9 0.7 0.6 1.0 1.0 1.0 1.1 1.2 1.1 0.8 0.9 1.4 1.4 1.2 1.4 0.4 1.1 1.1 1.0 -0.8 1.1 1.1 1.1 0.9 1.1
Pack years of smoking 0.3 0.5 1.2 0.7 0.8 0.8 0.2 -1.1 -1.1 -1.0 0.4 0.4 0.4 0.6 -0.5 0.6 0.9 0.2 0.6 -0.0 0.3 0.8 0.7 0.5 0.4 -0.9 1.0 0.4 0.3 -0.9 1.1 1.0 0.9 0.7 0.6
Impedance of whole body 0.6 2.9 4.8 1.7 1.9 0.5 0.8 -1.8 -1.9 -1.5 2.1 0.6 1.7 2.0 0.4 1.8 1.8 2.0 1.5 -0.2 2.2 1.9 1.6 1.6 1.7 1.2 1.9 1.9 2.0 -1.6 1.8 1.9 2.0 2.0 2.0
Leg fat mass (left) 0.1 0.5 2.0 -0.5 -0.5 0.5 0.2 1.2 1.1 1.2 -0.7 0.0 -1.4 -0.4 0.3 -0.6 -0.1 -0.3 0.1 0.3 -1.4 -0.0 -0.2 0.4 0.4 -1.3 -0.7 -0.1 0.1 1.0 -1.0 -1.1 -0.8 -1.0 -0.3
Arm predicted mass (left) 0.9 4.5 8.2 -2.3 -2.0 -1.8 -1.5 1.7 1.6 1.5 -2.5 -1.9 -1.6 -2.5 0.1 -2.3 -2.1 -2.3 -2.3 -2.1 -2.0 -2.5 -2.4 -2.5 -2.4 -2.9 -2.2 -2.7 -2.8 1.1 -1.5 -1.6 -1.9 -2.1 -2.5