Hub : Genes

TBC1D23

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0960 0.0410 2.8e-03 0.090 NA 0.071 NA 0.084 2.8e-07 NA 5.0e-06 NA 7.6e-07
2 GTEx Esophagus Mucosa 0.0540 0.0300 9.6e-03 0.007 NA 0.012 NA 0.015 1.1e-01 NA 5.1e-02 NA 3.2e-02
3 GTEx Heart Atrial Appendage 0.1420 0.0600 2.7e-03 0.105 NA 0.093 NA 0.088 1.9e-05 NA 5.7e-05 NA 9.2e-05
4 GTEx Muscle Skeletal 0.3602 0.0592 0.0e+00 0.248 NA 0.258 NA 0.260 3.4e-24 NA 3.1e-25 NA 2.0e-25
5 GTEx Skin Sun Exposed Lower leg 0.0610 0.0260 6.5e-04 0.040 NA 0.051 NA 0.055 2.8e-04 NA 4.9e-05 NA 2.4e-05
6 GTEx Stomach 0.0820 0.0410 5.8e-03 0.018 NA 0.013 NA 0.021 4.5e-02 NA 7.8e-02 NA 3.5e-02
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0807 0.0336 7.6e-08 0.093 0.088 0.084 NA 0.090 1.4e-10 4.6e-10 1.2e-09 NA 2.4e-10
8 TCGA Kidney Renal Clear Cell Carcinoma 0.0595 0.0375 9.7e-03 0.013 0.003 0.009 NA 0.008 1.0e-02 1.5e-01 3.1e-02 NA 3.7e-02
9 TCGA Kidney Renal Papillary Cell Carcinoma 0.0630 0.0360 3.9e-03 0.021 0.025 0.027 NA 0.018 2.1e-02 1.4e-02 1.0e-02 NA 3.2e-02
10 TCGA Pancreatic Adenocarcinoma 0.1430 0.0750 5.3e-04 0.102 0.072 0.058 NA 0.097 4.7e-05 6.0e-04 1.9e-03 NA 7.1e-05
11 TCGA Prostate Adenocarcinoma 0.0361 0.0196 1.4e-03 0.002 0.015 0.011 NA 0.006 2.0e-01 8.6e-03 2.2e-02 NA 7.1e-02
12 TCGA Thyroid Carcinoma 0.0890 0.0410 9.5e-05 0.022 0.036 0.037 NA 0.015 2.8e-03 1.8e-04 1.6e-04 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.9 1.4 6.7 1.4 0.4 -0.3 -0.2 0.2 0.2 1.0 0.6 0.3 1.9 1.4 2.6
Bipolar Disorder or Schizophrenia 0.5 1.2 5.9 1.3 -0.3 0.4 0.5 -0.2 -0.4 1.6 -0.3 0.3 2.0 0.6 2.4
Depressed Affect (Nagel 2018) 0.4 0.9 2.8 1.0 0.5 -0.4 0.0 1.4 1.7 0.9 0.1 0.2 1.2 -0.0 1.4
Depression (Nagel 2018) 0.5 0.8 3.2 0.5 0.9 -0.7 -0.0 0.6 1.3 0.7 -1.8 -0.4 1.1 0.1 0.9
Intelligence (Savage-Jansen 2018) 1.8 5.6 16.2 3.7 1.3 -2.1 -3.1 -0.4 0.4 -0.3 0.4 3.4 1.0 4.0 3.0
Neuroticism (Nagel 2018) 1.1 2.5 7.1 2.7 1.1 -0.8 -1.1 1.8 1.8 1.4 -0.7 2.0 1.5 1.5 1.5
Schizophrenia (2018) 0.3 0.6 1.4 0.5 -0.7 0.7 0.7 -0.4 -0.6 1.2 -0.9 0.2 1.0 -0.4 1.0
Schizophrenia vs Biploar Disorder 1.5 2.0 8.6 -1.7 -0.2 -0.5 -0.2 -0.9 -0.5 -1.8 0.7 -0.2 -2.5 -1.0 -2.9
Worry (Nagel 2018) 0.7 1.5 4.2 1.9 0.0 -1.9 -2.0 -0.1 0.0 -0.3 -0.3 2.0 0.1 1.7 0.3
Alzheimer’s Disease (in mother) 0.4 0.4 2.0 -0.2 -0.2 -0.8 -0.5 -1.4 -0.9 -0.5 0.6 -0.4 0.0 0.3 0.5
Alzheimer’s Disease (in father) 0.5 0.5 2.2 -0.8 0.8 -0.0 0.5 0.6 1.3 -0.4 -0.4 -0.3 -0.2 -0.3 -1.5
Alzheimer’s Disease (including proxy) 0.1 0.2 0.5 -0.7 0.4 -0.5 -0.1 -0.5 0.0 -0.6 0.0 -0.5 0.0 -0.2 -0.7
Crohns Disease (2017) 0.9 2.0 5.3 0.8 2.1 1.2 1.1 2.1 2.3 1.1 -1.4 1.2 0.4 -0.1 1.3
Irritable Bowel Disease (IBD) 1.0 2.5 9.6 1.2 2.4 0.3 0.7 2.4 3.1 1.2 -0.8 1.0 1.1 0.5 1.4
Ulcerative Colitis (UC) 0.8 1.5 6.5 1.1 1.6 -0.6 0.2 1.5 2.6 0.9 0.0 0.2 1.4 0.9 1.3
Major Depression (MDD) 0.9 1.1 4.3 -1.2 -0.9 0.7 1.0 -1.1 -1.2 0.1 -1.2 -2.1 1.0 -0.8 -0.2
Reaction Time 1.0 1.8 4.7 2.2 0.6 -0.9 -1.1 0.7 1.0 0.9 -1.2 1.6 1.5 1.8 1.8
Verbal and Numeric Reasoning (VNR) 0.5 1.1 3.0 1.6 0.4 -0.7 -1.3 0.1 0.6 -0.2 0.4 1.7 0.2 1.7 1.5
Breast Cancer 3.3 8.0 28.1 -2.6 -4.8 1.3 -0.1 -3.4 -5.3 -2.0 1.4 -1.7 -2.5 -2.3 -2.2
Ovarian Cancer 1.9 2.5 4.6 0.2 -2.1 -1.3 -1.9 -2.2 -2.0 -1.8 1.3 1.5 -1.8 0.7 0.2
Prostate Cancer 0.3 0.4 1.6 0.1 0.6 0.1 -0.1 0.8 1.2 -0.2 1.1 -0.2 0.4 0.7 0.1
Age at First Birth 0.5 0.8 2.3 0.3 0.0 -0.7 -0.9 -0.5 -0.2 -1.1 -0.2 1.5 -1.1 1.5 0.6
Bipolar Disorder (2011) 1.8 1.7 6.4 1.4 -1.1 0.3 -0.5 -1.3 -1.6 0.4 -1.3 0.8 1.2 1.6 2.5
Body Mass Index (BMI) (2010) 0.5 0.7 2.1 -0.1 1.0 0.5 1.0 1.5 1.0 1.3 -0.2 -0.1 0.4 -0.7 -0.3
Coronary Artery Disease (CAD) 1.8 2.1 7.8 0.8 -0.2 -2.8 -1.9 -1.1 -0.1 -2.3 1.1 1.2 -1.3 1.6 0.4
Crohns Disease (2012) 1.6 2.5 6.1 1.6 1.7 1.4 0.9 1.7 1.7 1.4 -2.5 1.1 1.6 0.9 1.9
Mean Putamen Volume 0.3 0.3 1.3 -0.2 0.6 -0.2 -0.3 0.8 0.5 -0.3 0.6 0.1 -0.6 -0.1 -1.1
Fasting Glucose 0.4 0.5 1.3 0.5 0.0 -0.1 -0.9 -0.9 -0.5 -1.0 0.2 0.4 -0.3 1.1 1.1
HbA1C 0.6 0.7 3.2 -1.4 -0.0 -0.3 0.7 0.2 0.5 -0.1 -0.7 -0.6 -1.1 -0.8 -1.8
HDL Cholesterol 0.6 1.0 4.7 0.3 -0.8 0.4 0.6 -0.3 0.2 0.1 -1.7 -0.1 1.5 0.9 2.2
LDL Cholesterol 1.2 1.9 5.6 1.3 -0.5 -1.8 -2.4 -1.2 -1.2 -1.2 0.8 2.0 -1.0 1.3 0.2
Lupus 1.5 2.3 9.3 -0.2 -2.2 -0.6 -1.0 -2.9 -3.0 -1.3 0.3 0.2 -1.1 0.6 -0.5
Neuroticism (2016) 0.9 1.2 6.1 1.5 0.6 -0.3 -0.2 1.0 1.2 0.5 0.7 0.8 1.1 1.0 2.5
Primary Biliary Cirrhosis 2.7 3.9 10.5 3.2 1.1 -1.3 -1.7 0.7 1.4 1.2 -0.8 2.6 1.9 2.8 2.9
Rheumatoid Arthritis 0.5 0.7 1.9 0.5 -1.0 0.8 -0.1 -0.8 -1.2 0.7 -0.8 -0.0 0.9 0.7 1.4
Schizophrenia (2014) 0.2 0.5 1.7 0.9 -0.4 0.6 0.2 -0.2 -0.2 0.9 -1.3 0.7 1.1 0.3 0.7
Triglycerides 1.2 1.9 4.3 -0.5 -1.3 -1.3 -1.0 -1.1 -1.7 -1.3 2.1 0.5 -1.9 -0.7 -1.9
Type 2 Diabetes (T2D) (2012) 0.8 0.9 3.0 -0.7 -0.9 0.8 0.5 -1.7 -1.6 -0.6 -0.7 0.1 -1.0 -0.3 0.7
Ulcerative Colitis 0.5 0.7 2.1 1.0 1.3 -0.5 -0.1 0.5 1.5 0.3 -0.0 0.2 1.0 1.1 1.0
Blood Eosinophil Count 0.1 1.0 2.8 1.4 0.5 0.7 -0.6 1.2 0.2 1.7 0.4 0.4 1.5 0.7 1.3
Blood Platelet Count 0.1 1.4 5.8 0.2 -1.1 2.4 1.2 0.9 -0.1 1.7 -0.2 -1.1 1.8 -0.3 0.4
Blood Red Count 0.1 0.9 3.2 -0.8 -0.5 1.0 1.5 0.3 -0.3 1.4 -0.0 -1.0 0.5 -1.8 -0.0
Blood White Count 0.3 2.3 9.5 0.1 2.1 0.9 1.3 2.7 3.1 1.6 -1.0 -0.1 1.0 -0.3 0.2
Heel T-Score 0.8 6.4 23.5 -1.1 -1.8 -1.0 -1.5 -4.8 -4.8 -2.8 -1.0 0.6 -3.1 -0.4 -1.8
BMI 0.2 1.0 3.0 0.3 1.4 -0.3 0.7 0.9 1.7 1.3 -0.0 -0.4 1.4 -0.2 1.1
Height 0.4 8.1 24.2 3.6 -0.9 -0.0 -0.6 3.8 1.8 2.9 2.7 1.1 4.3 2.5 4.9
Waist Hip Ratio (WHR) 2.1 9.5 39.2 2.2 3.5 0.8 -0.2 6.0 6.3 3.0 1.1 1.9 2.5 1.0 0.3
Systolic Blood Pressure 2.3 11.3 23.4 -4.8 -2.5 3.2 3.9 -2.9 -4.3 -0.5 -0.4 -4.4 -1.9 -4.8 -2.7
Smoking Status 0.1 0.3 1.0 -0.6 0.1 0.5 0.4 0.2 0.1 0.0 -1.0 -0.6 0.0 -1.0 -0.4
Allergy or Eczema 0.2 0.5 1.9 -0.7 -1.3 0.1 -0.0 -0.6 -1.0 -0.5 0.6 -0.4 -0.4 -0.4 -1.4
Cardiovascular Disease 1.3 4.4 9.1 -2.6 -2.5 1.6 1.9 -2.9 -3.0 -0.5 -0.8 -3.0 -0.5 -2.3 0.8
Hypothyroidism (self reported) 0.6 1.4 3.3 -1.1 -1.3 1.8 1.3 -0.4 -1.4 0.7 -0.2 -1.7 -0.1 -1.8 0.2
Respiratory disease 1.0 2.3 7.6 0.4 0.4 1.6 1.4 2.8 2.5 2.2 -1.0 -0.1 1.2 -1.1 0.4
Type 2 Diabetes (T2D) (2018) 0.6 1.2 3.5 1.9 -1.6 0.1 -1.0 0.1 -0.0 0.6 -0.9 0.8 1.6 1.4 1.1
Lung FEV1/FVC ratio 0.3 1.7 7.5 1.1 -2.2 -0.2 -1.1 0.0 0.2 -0.9 1.1 0.2 1.1 2.7 1.6
Lung FVC 1.6 8.2 28.7 -1.5 1.0 -3.0 -1.9 -5.4 -3.7 -3.7 1.3 1.1 -4.5 0.3 -1.9
Neuroticism 0.4 1.0 3.0 1.3 -0.2 -1.4 -1.7 -0.0 0.6 -0.3 0.3 1.6 0.1 1.2 0.8
Chronotype (morning person) 0.2 0.4 1.3 0.3 -0.9 -0.3 -0.5 -1.0 -0.4 -0.3 0.1 -0.3 0.4 1.2 1.0
Hair Pigment 0.1 2.9 10.4 1.6 2.9 -0.5 0.6 1.4 2.1 1.8 -0.3 0.7 1.7 0.6 3.2
Tanning 0.2 2.1 6.4 -1.1 1.2 1.1 1.8 2.5 2.3 1.0 0.5 -1.0 0.4 -1.7 -1.3
Hand grip strength (left) 0.7 1.7 7.4 0.0 -2.7 -0.0 -0.7 -1.6 -1.5 -0.8 1.1 -0.8 0.9 1.5 1.5
Number of treatments/medications taken 0.3 0.5 1.4 0.3 0.5 1.0 0.9 0.6 0.2 1.2 -0.5 -0.6 0.8 -0.7 0.8
Average weekly spirits intake 0.5 0.6 3.8 -0.6 -1.0 2.0 1.1 0.2 0.0 0.1 -0.8 -0.5 0.3 0.1 0.5
Sensitivity / hurt feelings 1.0 1.7 4.0 2.0 1.1 -0.1 -0.6 1.6 1.5 1.5 -1.3 1.4 1.3 0.9 1.5
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.8 -0.2 0.6 -0.3 -0.2 -0.1 0.9 -0.1 -0.7 -0.5 0.1 -0.3 -0.2
Hearing difficulty/problems: Yes 1.7 2.5 10.9 0.2 3.3 -1.7 -0.2 1.7 2.1 0.6 0.7 1.0 -0.9 -1.3 -2.2
Relative age of first facial hair 0.3 0.7 1.9 -1.3 -0.5 0.8 1.4 -0.7 -1.0 0.3 0.1 -1.3 -0.3 -0.9 -0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.7 1.0 -0.2 0.4 -0.7 -0.5 -1.0 0.2 -0.4 1.4 0.0 1.1 1.9
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.9 1.2 0.4 1.4 0.5 1.2 0.8 1.7 -0.1 0.2 1.6 0.5 1.5
Ever had hysterectomy (womb removed) 1.0 1.1 2.5 -0.2 0.5 1.2 0.9 1.5 1.0 1.5 -1.6 -0.1 0.8 -0.9 -1.1
Systolic blood pressure, automated reading 0.9 2.8 7.1 -1.9 -0.5 1.4 2.0 -1.6 -2.4 0.8 -0.4 -1.7 -0.3 -2.7 -2.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.0 -0.0 -0.5 -0.7 -0.2 -0.5 -0.1 -0.8 -1.0 -0.4 -0.3 0.0 -0.5
Angina 2.4 3.1 7.7 -2.2 -1.3 2.0 2.7 -0.4 -1.1 0.9 -1.2 -2.8 0.6 -2.4 -1.5
Medication for hormone replacement therapy 0.4 0.5 2.1 0.0 -0.2 1.1 0.2 0.3 0.4 -0.1 0.3 -0.6 0.9 0.9 1.4
Vitamin and mineral supplements 1.3 1.8 5.8 -1.6 1.3 0.5 1.6 1.2 1.4 0.3 0.8 -0.8 -1.4 -2.4 -1.3
Supplements: Zinc 1.2 1.3 5.6 0.5 1.9 0.0 0.1 2.1 2.4 0.8 0.4 0.5 0.3 0.1 -1.0
Medication: Co-codamol 1.4 1.6 5.0 -1.6 0.5 -1.1 0.1 -0.5 -0.1 -1.8 0.5 -0.9 -2.2 -1.3 -2.2
Medication: Metformin 1.1 1.5 4.2 1.2 0.1 1.2 0.6 2.0 1.6 1.5 -1.9 0.7 1.4 0.1 -0.1
Diabetes (father) 0.8 0.9 4.1 1.2 2.0 0.1 -0.3 0.7 0.7 0.9 -1.2 1.0 0.7 0.6 0.8
Diabetes (mother) 2.4 3.1 6.5 2.5 2.0 -2.1 -2.0 0.5 1.4 0.4 1.6 2.5 0.4 2.0 1.8
Severe depression (siblings) 0.2 0.2 0.7 -0.5 0.1 0.3 0.5 -0.1 0.2 -0.1 -0.6 -0.7 0.4 -0.0 0.8
Pack years adult smoking proportion 0.4 0.6 1.5 -0.7 -0.4 1.2 1.2 1.1 0.3 1.0 -0.1 -0.5 0.7 -0.8 -0.4
Impedance of leg (right) 0.6 3.0 10.8 1.6 2.8 -0.8 -0.4 3.1 3.3 1.1 -0.1 1.3 0.7 0.9 0.6
Leg fat-free mass (left) 0.3 1.8 7.5 0.9 -2.0 1.1 -0.1 -0.6 -1.2 0.7 0.0 0.1 1.8 1.5 2.7
Trunk fat percentage 1.3 5.1 20.0 1.1 4.0 0.1 0.8 3.8 4.5 2.1 -1.1 0.7 1.7 0.1 1.1
Hand grip strength (right) 0.5 1.5 6.3 1.1 -1.1 0.6 -0.5 -0.3 -0.2 0.2 -0.2 0.2 1.8 2.2 2.5
Townsend deprivation index at recruitment 0.7 1.0 3.3 -0.5 1.3 0.3 1.0 1.8 1.8 0.8 0.7 -0.3 0.1 -1.0 -0.7
Current tobacco smoking 1.0 1.6 4.0 -2.0 0.2 1.4 1.7 -0.2 -0.2 -0.5 -1.3 -1.3 -1.3 -2.0 -1.0
Average weekly fortified wine intake 0.4 0.4 1.2 0.8 0.8 -0.8 -0.8 0.6 0.5 0.5 0.2 0.7 -0.1 -0.3 -1.1
Maternal smoking around birth 0.2 0.3 0.9 0.0 -0.9 0.6 0.1 -0.3 -1.0 -0.4 -0.5 0.1 -0.5 -0.3 -0.0
Fed-up feelings 1.0 1.8 8.8 0.4 1.8 -0.0 0.6 2.5 3.0 1.4 -0.3 0.1 0.7 -0.8 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.0 -1.5 0.8 0.3 1.2 0.6 0.9 0.3 -1.5 -1.5 -0.1 -1.7 -1.7
Relative age voice broke 0.3 0.4 0.9 -0.7 -0.6 0.5 1.0 -0.2 -0.9 0.3 0.6 -0.6 -0.4 -0.8 -0.6
Taking other prescription medications 0.4 0.6 2.1 -1.0 -0.8 1.2 0.7 0.1 -0.4 -0.1 -0.2 -1.0 -0.4 -1.4 -0.4
Age when periods started (menarche) 2.2 5.4 14.2 -3.8 -0.6 2.0 2.1 -1.4 -1.5 -2.2 -0.9 -1.8 -3.5 -3.1 -2.6
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 6.4 2.5 1.6 0.4 -1.0 2.0 1.7 1.5 -1.4 1.8 1.6 1.5 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 3.9 0.2 -0.1 -0.2 -1.1 -2.0 -1.8 -0.8 -0.7 0.7 -0.5 0.8 -0.3
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 9.8 -1.0 -2.7 1.2 -0.5 -2.1 -3.1 -0.9 1.3 -0.7 -0.7 -0.1 0.2
Qualifications: CSEs or equivalent 0.4 0.5 2.7 0.3 -0.1 -0.8 -0.3 -0.6 -0.4 -0.6 -1.7 -0.1 0.5 0.6 0.9
Serious illness, injury or assault to yourself 0.2 0.3 0.9 0.1 -0.4 0.5 0.0 -0.2 -0.7 -0.1 -0.9 -0.3 0.8 0.5 0.8
High blood pressure 1.0 2.8 6.1 -2.0 -1.6 1.1 1.7 -2.2 -2.5 -0.0 -0.3 -2.4 -0.5 -2.5 -0.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.5 0.1 -0.5 -1.1 -1.1 -0.6 -0.3 -1.2 1.0 0.7 -0.8 0.8 -0.6
Multivitamins +/- minerals 0.7 0.9 4.0 1.3 -0.7 -0.2 -1.1 -0.3 -0.6 0.1 0.2 0.6 1.3 2.0 1.0
Stomach or abdominal pain in last month 0.3 0.4 1.4 -0.5 1.1 -0.5 0.2 -0.1 0.4 -0.4 0.2 0.5 -1.2 -0.8 -0.6
Supplements: Glucosamine 1.1 1.5 4.8 2.2 0.0 -1.4 -1.3 0.8 0.2 0.7 1.0 1.6 1.2 1.5 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 0.7 -0.4 0.2 0.1 0.0 0.5 1.1 1.4 0.2 1.3 0.7 1.2
Medication: Atenolol 2.4 3.0 7.2 -2.7 -1.7 1.4 1.8 -1.8 -1.8 -0.8 -1.4 -2.5 -0.5 -1.9 -1.1
Medication: Levothyroxine sodium 1.4 2.4 5.5 -2.0 -2.4 1.2 0.8 -1.8 -1.8 -0.6 -0.1 -2.2 -0.8 -1.7 -1.2
Sitting height 0.1 0.9 4.5 0.8 -1.1 1.2 0.1 0.6 -0.7 0.5 -0.3 1.0 0.3 0.7 2.1
Chronic bronchitis/emphysema (father) 1.7 2.0 9.6 0.8 0.9 0.1 1.0 3.1 2.7 1.8 -0.6 0.4 1.1 -0.4 -0.1
High blood pressure (mother) 1.3 1.9 5.3 -0.4 -2.3 0.9 0.0 -2.2 -2.2 -0.9 -2.0 -0.4 0.1 0.5 1.1
Body mass index (BMI) 0.2 0.9 3.3 0.4 0.6 0.6 0.6 0.5 0.9 1.2 -1.1 -0.4 1.8 0.3 1.3
Impedance of leg (left) 0.6 2.7 9.9 1.3 3.0 -0.9 -0.5 3.0 3.1 0.7 0.1 1.3 0.2 0.5 0.3
Leg predicted mass (left) 0.3 1.8 7.8 0.9 -2.0 1.0 -0.1 -0.6 -1.2 0.8 0.0 0.2 1.9 1.5 2.8
Trunk fat mass 0.8 3.5 10.1 1.4 2.5 0.3 0.5 2.8 3.2 2.0 -0.9 0.6 2.3 0.7 2.1
Waist circumference 1.6 6.0 19.5 1.8 3.7 0.1 0.6 3.9 4.4 2.9 -0.5 0.4 3.1 0.6 1.3
Number of incorrect matches in round 0.2 0.3 1.8 0.5 0.1 -0.2 -0.6 -0.6 -1.3 0.0 -0.6 0.7 -0.3 -0.1 -0.5
Past tobacco smoking 0.4 0.7 2.7 -1.6 0.2 0.3 1.1 -0.6 0.7 -1.0 -0.0 -1.5 -0.6 -0.3 -0.1
Alcohol usually taken with meals 0.7 1.1 5.6 -0.4 -0.4 -1.3 -0.9 -2.4 -1.5 -1.3 0.4 0.2 -0.9 0.4 -0.2
Nervous feelings 0.2 0.3 1.0 0.7 0.3 -0.2 -0.5 0.0 0.2 0.3 -1.0 1.0 0.2 0.6 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 -0.7 0.6 0.4 0.5 0.0 0.5 -0.2 -1.4 0.0 -0.7 -0.5 -1.4
Hearing difficulty/problems with background noise 1.5 2.5 7.2 -0.2 0.6 -2.4 -1.8 -1.1 -0.3 -2.7 1.8 1.2 -2.5 0.3 -1.0
Hair/balding pattern: Pattern 2 0.8 1.0 4.8 0.4 -0.4 0.8 0.3 0.3 0.1 2.1 0.2 -1.0 2.2 0.0 1.0
Had menopause 1.0 1.3 4.3 1.3 1.4 -0.7 -0.3 1.4 0.6 2.1 0.6 0.7 1.6 -0.2 -0.9
Had other major operations 2.0 2.5 8.5 0.7 -0.1 1.8 1.0 1.0 1.1 2.1 -2.3 -1.0 2.9 0.7 1.6
Forced vital capacity (FVC) 0.6 2.3 6.1 0.3 0.0 -1.2 -1.2 -2.5 -2.0 -1.8 1.4 1.2 -1.7 1.7 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 3.0 -0.2 -0.2 0.6 -0.1 -1.3 -1.1 -0.3 -1.7 0.2 -0.3 0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.4 -1.8 0.2 1.3 1.7 0.5 0.9 0.0 -0.5 -1.4 -0.2 -1.0 -0.9
Qualifications: None of the above 0.3 0.7 2.4 -0.3 0.7 1.0 0.8 1.1 0.2 1.0 -0.4 -0.1 -0.4 -1.6 -1.1
Financial difficulties in last 2 years 2.0 2.7 5.4 -2.0 -1.1 -0.4 -0.5 -2.3 -2.0 -2.2 1.1 -0.7 -2.2 -1.2 -2.3
Mouth/teeth dental problems 1.0 1.5 4.9 1.5 0.4 -1.9 -1.7 -0.1 0.8 -0.9 0.3 1.4 0.5 2.2 0.8
Heart attack 1.2 1.6 3.1 -1.0 1.4 0.8 1.6 1.5 1.8 0.8 -0.2 -1.6 0.4 -1.6 -1.3
Allergy 0.2 0.4 1.0 0.1 0.6 0.3 0.5 -0.4 -0.2 0.5 -0.9 -0.6 0.9 0.3 1.0
Pain all over the body in last month 0.4 0.4 1.3 0.3 0.1 -0.7 -0.7 -0.2 -0.5 -0.5 -1.1 0.9 -0.4 0.6 -0.8
Diabetes (self-reported) 0.7 1.1 3.2 0.8 -0.3 0.9 0.7 1.3 1.5 1.1 -1.8 -0.0 1.6 0.2 0.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.5 1.3 0.3 -1.1 -1.1 0.1 -0.3 0.2 -1.1 1.9 0.0 0.6 0.7
Medication: Ramipril 0.9 1.2 2.2 -0.5 0.9 0.8 1.5 0.8 0.5 1.4 -0.8 -1.5 0.9 -1.5 -1.2
Medication: Simvastatin 0.4 0.6 1.6 -1.3 -0.0 0.6 0.6 -0.2 -0.1 -0.9 0.2 -0.7 -1.2 -1.2 -0.3
Fluid intelligence score 0.3 0.6 1.3 0.7 0.5 -0.5 -1.1 -0.9 -0.3 -0.8 0.4 0.9 -0.5 1.0 1.1
Illnesses of siblings 1.5 2.1 6.4 2.2 0.3 -1.4 -2.2 0.4 0.8 0.3 1.1 1.4 1.2 2.5 1.3
Neuroticism score 0.2 0.4 0.7 0.8 0.2 -0.8 -0.8 0.5 0.7 0.3 -0.1 0.9 0.3 0.3 0.6
Weight 0.4 2.1 9.4 1.5 -0.1 0.6 0.1 0.8 0.7 1.5 -0.3 0.2 2.7 1.5 3.1
Impedance of arm (right) 1.0 4.6 18.3 0.1 4.3 -0.5 0.8 3.5 4.2 0.9 -0.7 1.0 -0.8 -0.9 -1.5
Arm fat percentage (right) 0.7 2.9 10.7 0.6 3.1 0.2 1.0 2.3 3.3 1.9 -1.1 0.0 1.7 -0.3 0.7
Trunk fat-free mass 0.9 5.2 17.3 1.6 -4.0 0.7 -0.8 -1.9 -2.8 0.4 1.0 -0.1 2.6 2.5 4.2
Hip circumference 0.5 2.1 5.2 1.0 2.0 0.1 0.8 1.4 1.9 1.7 -1.1 -0.3 2.3 0.7 2.0
Time employed in main current job 0.2 0.3 1.5 0.4 -0.2 -0.0 -0.1 0.1 0.0 0.2 0.5 -0.5 0.9 0.3 1.2
Alcohol intake versus 10 years previously 1.7 2.6 8.3 1.0 0.6 1.0 0.9 2.2 2.0 2.5 -1.0 -0.6 2.9 0.5 1.7
Father’s age at death 1.2 1.6 4.3 1.8 0.4 -0.0 -0.2 1.1 1.6 1.7 -0.0 0.9 2.1 1.3 1.4
Worrier / anxious feelings 1.0 1.9 4.8 2.1 0.5 -0.9 -1.0 1.0 0.9 1.4 -0.8 0.9 2.2 1.7 1.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 2.2 -0.0 0.7 0.7 0.2 0.6 0.8 0.7 -1.5 -0.1 0.5 0.0 -0.0
Falls in the last year 1.4 1.8 6.5 0.2 2.5 -0.6 0.3 2.2 2.0 1.0 -0.7 1.1 -0.4 -1.2 -1.5
Hair/balding pattern: Pattern 3 0.4 0.5 1.7 0.3 1.3 -0.5 -0.1 0.7 0.9 -0.1 0.1 1.1 -0.9 -0.8 -0.5
Number of live births 3.3 4.7 11.8 -3.3 -1.2 2.1 2.4 -1.2 -1.3 -0.4 -0.3 -3.0 -1.6 -3.4 -2.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 6.1 1.1 -0.5 -1.0 -1.6 -2.2 -1.9 -1.5 0.8 1.6 -0.9 2.5 1.9
Pulse rate 1.1 1.9 5.8 1.3 -0.0 0.8 0.4 2.4 2.1 1.8 0.2 0.5 1.9 0.7 1.4
Happiness 0.1 0.2 0.4 0.0 -0.4 0.5 0.3 0.5 0.4 0.5 -0.4 -0.4 0.6 -0.4 0.1
Noisy workplace 1.4 1.7 3.2 -1.2 1.6 -0.3 1.2 1.8 1.7 0.2 1.4 -0.2 -1.3 -1.8 -1.6
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.7 0.8 -0.1 -1.3 -1.5 -0.8 0.3 -1.2 0.1 1.0 -0.2 1.6 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.4 0.6 -0.5 -0.6 0.3 0.6 -0.3 0.3 0.2 0.1 0.5 0.6
Mouth/teeth dental problems: Dentures 1.3 2.3 5.1 -0.9 0.2 2.3 2.3 1.4 0.4 2.1 0.3 -2.1 1.2 -1.9 0.3
Asthma 0.3 0.6 1.8 0.7 -0.5 0.3 0.0 1.4 1.1 1.3 -0.3 0.4 0.8 -0.4 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 3.5 0.5 0.8 -1.5 -1.6 -0.5 0.7 -1.2 1.0 1.1 -0.5 1.9 0.2
Medication: Cholesterol lowering 0.7 1.1 3.3 -1.0 -1.7 0.2 0.3 -0.3 -0.7 -1.1 -0.8 -0.9 -0.9 -1.4 -1.8
Depression (self-reported) 1.0 1.2 3.1 -0.5 1.2 0.2 1.0 0.7 0.6 1.4 -1.8 -0.6 0.4 -1.7 -1.6
Medication: Lansoprazole 2.2 2.5 7.5 2.0 1.1 1.1 0.4 2.2 1.5 2.7 -0.4 1.0 2.0 0.5 1.8
Prospective memory result 1.0 1.2 4.6 1.0 1.0 -0.2 0.1 1.8 2.2 1.5 0.3 0.9 1.1 0.5 0.3
Lung cancer (father) 0.6 0.7 3.6 0.0 0.4 -1.4 -0.9 0.0 0.3 -0.9 1.9 0.2 -0.9 0.1 -0.3
Illnesses of mother 0.5 0.6 2.4 -0.2 0.5 -0.6 -0.4 1.4 1.1 -0.0 0.9 -0.0 -0.4 -0.3 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 6.2 0.9 -0.4 -1.4 -1.7 -2.3 -1.6 -2.1 -0.1 1.8 -1.4 2.5 1.3
Pulse wave Arterial Stiffness index 0.4 0.5 2.2 -0.7 0.2 -0.0 -0.2 -0.2 -0.2 -0.7 1.4 0.2 -1.5 -0.5 -0.8
Impedance of arm (left) 1.0 4.5 17.9 0.2 4.2 -0.6 0.6 3.4 4.2 0.9 -0.7 1.3 -1.0 -0.9 -1.4
Arm fat mass (right) 0.5 2.2 7.1 1.1 1.3 0.5 0.7 1.6 2.0 2.0 -0.9 -0.2 2.7 0.6 2.1
Trunk predicted mass 0.9 5.4 18.6 1.7 -3.9 0.5 -0.9 -1.9 -2.8 0.4 1.1 0.0 2.6 2.6 4.3
Standing height 0.5 4.5 19.6 2.7 -1.9 0.1 -1.2 0.8 -0.2 1.0 1.5 1.4 2.6 3.1 4.4
Length of working week for main job 0.3 0.4 1.5 0.2 1.1 0.2 -0.1 1.2 0.9 0.3 0.4 0.5 0.0 0.2 -0.4
Exposure to tobacco smoke at home 0.2 0.2 0.9 -0.2 0.3 -0.8 -0.5 -0.3 -0.5 -0.1 -0.1 -0.2 -0.0 -0.2 -0.9
Breastfed as a baby 0.4 0.4 2.3 0.0 -0.2 -1.5 -0.8 -0.5 0.2 -0.7 0.9 0.1 -0.5 -0.1 -0.7
Tense / ‘highly strung’ 0.4 0.7 1.8 0.6 -1.3 -0.6 -1.3 -0.8 -0.8 -0.4 1.3 0.7 -0.0 1.0 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.5 -1.4 1.3 0.0 0.8 1.2 1.6 -0.3 1.0 -0.2 -1.3 -1.4 -1.3
Hair/balding pattern: Pattern 4 0.5 1.1 4.0 0.8 -2.0 -0.0 -0.9 -0.9 -1.4 -0.7 -0.7 0.7 0.2 1.4 1.4
Birth weight of first child 0.6 1.0 2.9 0.7 0.8 -1.5 -1.7 0.3 0.2 -1.1 1.4 1.0 -0.6 0.8 -1.0
Peak expiratory flow (PEF) 1.3 3.0 5.8 1.1 -0.4 -1.7 -2.4 -1.8 -1.3 -2.2 1.6 1.7 -1.5 2.4 1.5
Pulse wave reflection index 1.9 2.3 7.7 -0.5 -0.2 -0.6 -1.5 -2.0 -1.9 -2.1 1.8 1.0 -2.8 0.4 -0.8
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.9 -2.2 -0.5 1.5 1.5 -0.2 -0.5 -0.9 -1.2 -1.1 -1.3 -1.1 -2.0
Loud music exposure frequency 1.7 1.8 6.8 0.1 -2.6 1.1 -0.6 -1.8 -2.2 -1.0 -1.0 0.7 -0.6 1.0 1.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.3 0.5 -0.1 -1.1 -0.8 -0.1 0.6 -0.4 0.5 -0.0 0.7 1.0 0.5
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.8 -1.4 -0.6 1.1 0.4 -0.5 -0.8 -0.5 -2.2 -0.2 -1.3 -1.3 -1.8
Blood clot in the leg (DVT) 0.3 0.4 1.4 -0.8 0.4 -0.2 0.2 0.0 0.3 -0.9 1.2 -0.4 -0.9 -0.4 -0.3
Medication: Paracetamol 0.7 1.1 5.1 1.5 0.6 0.4 -0.0 0.8 0.4 1.0 -2.3 1.3 0.7 0.8 1.0
Headache pain in last month 0.6 1.1 3.6 0.3 -1.2 0.7 -0.4 -1.6 -1.9 -0.4 -1.4 1.0 -0.8 0.2 0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.9 0.6 1.2 0.2 -0.5 0.4 0.7 0.5 0.8 1.4 -0.0 1.3 0.6
Glaucoma (self-reported) 0.9 1.1 3.0 -0.8 -0.0 -1.1 -0.7 -1.3 -1.2 -1.4 1.7 -0.0 -1.4 -0.0 -0.8
Gout (self-reported) 1.4 1.9 4.2 -2.0 -1.8 0.4 0.3 -1.1 -1.2 -1.5 -0.4 -1.7 -1.2 -1.5 -2.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.4 -1.8 -1.6 1.2 1.1 -1.0 -1.5 -0.2 -0.5 -2.1 -0.7 -1.7 -0.6
Medication: Amlodipine 0.5 0.7 1.7 -0.9 -0.7 0.0 0.7 -1.1 -0.9 -0.1 1.3 -1.2 0.0 -0.8 -0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.5 0.5 -0.5 -0.5 -0.7 -0.3 0.2 -0.2 -0.1 0.2 0.5 0.7 0.7
Birth weight 0.4 0.9 2.0 -0.9 -0.0 1.4 1.1 1.0 1.3 0.3 1.1 -1.3 0.6 -0.0 -0.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.7 0.5 -0.3 1.6 1.0 0.4 -0.4 1.6 -1.1 0.0 1.3 -0.5 0.9
High blood pressure (siblings) 0.8 1.1 3.3 -1.2 0.1 0.1 0.7 -0.9 -0.9 -1.0 -1.1 0.2 -1.8 -1.4 -1.5
Forced vital capacity (FVC), Best measure 0.7 2.5 4.7 0.6 0.5 -1.6 -1.5 -2.1 -1.3 -2.1 0.4 2.1 -2.2 1.8 0.9
Body fat percentage 1.1 4.2 15.7 1.0 3.7 -0.0 0.7 3.2 4.0 2.0 -1.1 0.5 1.7 -0.0 1.0
Leg fat percentage (right) 0.8 3.0 8.8 1.3 2.7 -0.2 0.4 2.3 3.0 2.0 -0.8 0.2 2.4 0.6 1.5
Arm fat-free mass (right) 0.8 4.3 17.3 1.6 -3.3 1.0 -0.6 -1.3 -2.2 0.7 0.2 0.1 2.7 2.3 4.2
Exposure to tobacco smoke outside home 0.2 0.3 1.1 0.1 0.9 -1.0 -0.7 -0.4 0.4 -0.6 -0.7 0.1 -0.3 0.3 -0.5
Comparative body size at age 10 0.4 1.2 4.6 0.2 -0.8 -0.8 -1.5 -1.5 -0.8 -1.2 2.1 0.3 -0.4 1.3 -0.0
Number of full brothers 0.8 1.0 3.1 -1.7 0.7 0.4 1.1 0.2 0.3 -0.5 0.2 -1.8 -0.8 -1.4 -1.0
Worry too long after embarrassment 2.3 3.8 11.0 3.3 0.4 -1.7 -2.8 1.4 1.3 0.5 0.8 2.8 1.2 2.9 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.8 -1.5 -0.5 -0.3 0.4 -0.1 0.6 -0.4 1.0 -0.6 -1.0 -1.5 -1.7
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 -0.3 -0.1 0.8 1.0 0.6 0.7 0.9 0.1 -0.6 0.4 -1.1 0.2
Number of children fathered 0.6 0.7 2.7 -0.7 -0.7 0.5 0.7 -1.0 -1.1 -0.0 -1.7 -0.8 0.1 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 3.2 0.4 1.5 1.2 1.0 1.8 1.6 1.3 -0.8 0.2 0.8 -0.3 0.1
Age at first live birth 1.2 2.1 6.2 2.3 0.8 -1.2 -1.7 1.0 1.3 0.2 1.1 1.6 1.2 2.5 0.8
Pulse wave peak to peak time 0.6 0.7 2.9 0.8 -0.2 0.1 0.3 0.4 0.4 0.8 -1.3 -0.2 1.7 0.7 1.2
Health satisfaction 2.1 2.7 6.8 0.4 1.1 1.6 1.8 2.6 1.9 2.2 -1.7 -0.9 2.0 -1.0 1.1
Shortness of breath walking on level ground 1.3 1.5 7.5 0.2 1.0 1.1 1.2 1.6 1.1 1.3 -2.7 -0.2 1.0 -0.3 0.1
Qualifications: College or University degree 0.5 1.7 5.7 1.9 0.3 -1.0 -1.1 -0.5 0.6 0.2 0.8 2.1 0.6 2.4 1.6
Eye problems/disorders: None of the above 0.5 0.5 2.7 -0.3 -0.9 0.6 -0.1 -0.7 -0.3 -1.0 -1.7 0.4 -0.8 0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 3.6 -1.4 -0.4 1.0 1.6 0.1 0.0 0.6 -0.6 -1.1 0.0 -1.9 0.0
Emphysema/chronic bronchitis 0.4 0.5 1.4 -0.6 -0.0 0.3 0.7 0.7 0.7 0.1 -0.9 -0.5 -0.3 -1.2 -1.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 -0.8 -0.6 -0.5 -0.1 -0.6 -0.4 -0.9 0.3 -0.8 -0.1 0.1 -0.5
Neck or shoulder pain in last month 1.1 1.5 3.5 -1.6 -0.8 1.8 1.5 -0.3 -1.4 -0.1 -0.2 -0.4 -1.6 -1.9 -1.1
Medication: Blood pressure 0.3 0.6 2.4 -0.8 -1.0 -0.5 0.5 -0.9 -0.5 -0.9 -0.5 -1.5 0.0 -0.9 -0.2
Angina (self-reported) 2.9 3.8 9.1 -2.4 -1.6 2.2 2.8 -0.6 -1.5 0.8 -1.4 -3.0 0.5 -2.5 -1.6
Migraine (self-reported) 1.0 1.3 4.2 0.2 1.5 2.0 1.0 1.4 0.7 1.7 -0.8 0.5 0.2 -0.9 -0.5
Medication: Ibuprofen 1.2 1.4 4.5 0.8 1.4 -1.6 -1.8 -0.4 0.7 -1.0 0.5 1.3 -0.3 2.1 0.5
Medication: Allopurinol 0.5 0.7 3.0 -0.9 -0.6 0.0 0.2 -0.1 0.0 -0.5 -0.9 -1.2 -0.1 -1.1 -1.7
Medication: Omeprazole 0.4 0.5 2.8 1.1 0.3 0.3 -0.5 -0.1 -0.8 0.7 -0.6 1.7 -0.4 -0.0 -0.1
Medication: Seretide 50 evohaler 1.4 1.6 5.2 2.3 0.1 0.1 -0.9 1.0 0.4 2.0 -0.7 1.9 1.6 1.2 0.1
Mean time to correctly identify matches 0.9 1.8 3.6 1.8 1.8 -1.2 -0.8 1.2 1.9 1.0 -1.2 1.5 1.3 1.1 0.4
Heart disease (mother) 0.4 0.5 2.4 -0.6 -1.6 0.8 0.7 -0.5 -0.7 -0.1 -0.1 -0.4 -0.3 -0.7 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 4.1 -1.0 -0.4 -1.1 -0.5 -1.4 -0.8 -2.0 0.9 -0.5 -1.5 -0.6 -0.6
Whole body fat mass 0.6 2.7 6.5 1.3 2.1 0.2 0.5 2.1 2.5 1.9 -1.1 0.5 2.2 0.7 2.0
Leg fat mass (right) 0.6 2.3 6.9 1.2 1.3 0.6 0.6 1.7 1.8 2.1 -0.9 -0.0 2.6 0.7 2.2
Arm predicted mass (right) 0.7 3.8 14.8 1.2 -3.1 1.2 -0.2 -1.1 -2.1 0.7 0.3 -0.3 2.7 2.0 3.9
Pulse rate, automated reading 2.4 7.6 18.7 4.3 1.8 -1.4 -2.7 2.8 3.4 1.6 1.7 2.9 2.9 3.7 2.1
Alcohol intake frequency. 0.4 0.9 1.8 -0.7 0.9 0.8 1.0 1.4 1.2 0.8 0.9 -1.3 0.6 -1.0 -0.1
Comparative height size at age 10 1.2 6.8 18.3 4.0 -0.6 -0.5 -1.5 2.1 1.4 2.2 0.8 2.0 4.0 3.6 4.3
Number of full sisters 0.8 1.0 3.3 -1.0 -1.6 1.3 0.5 -0.9 -1.8 -0.8 0.2 -0.4 -1.1 -0.9 -0.2
Suffer from ‘nerves’ 0.5 0.7 5.1 -0.3 -0.7 0.0 0.0 -1.0 -0.7 -0.5 -2.2 -0.1 -0.3 -0.3 -0.9
Overall health rating 0.5 1.2 3.2 -1.1 -0.1 1.7 1.6 0.8 0.5 0.4 -1.8 -1.0 0.0 -1.4 -0.5
Chest pain or discomfort 1.1 1.6 4.9 -1.5 -0.4 0.9 1.3 0.1 -0.6 -0.3 -1.7 -1.1 -0.8 -2.2 -1.9
Had major operations 1.7 2.0 5.0 1.3 1.1 -2.2 -1.9 -0.2 0.8 -1.0 2.0 2.0 -1.0 1.2 0.9
Age at last live birth 0.5 0.8 1.5 -1.2 0.1 0.8 1.1 0.9 0.9 -0.3 0.9 -1.1 -0.5 -0.9 -0.9
Family relationship satisfaction 0.1 0.1 0.3 0.6 -0.5 -0.5 -0.5 0.1 -0.3 0.2 0.3 0.3 0.4 0.1 0.5
Leg pain on walking 0.2 0.2 0.7 0.7 0.1 -0.1 -0.4 0.3 -0.6 0.9 0.2 0.6 0.6 0.0 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.0 -0.6 -0.3 -1.2 -1.3 -1.4 -1.1 -2.0 0.7 0.4 -1.5 0.6 -0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.4 2.1 0.1 -0.5 -0.1 0.3 0.6 0.6 1.0 -0.5 -0.8 1.5 0.1 -0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.9 1.2 0.8 -1.4 -1.3 -0.5 -0.2 -0.1 0.5 1.2 -0.3 1.0 0.1
Medication: Aspirin 1.7 2.2 6.4 -1.6 0.0 2.2 2.3 1.0 0.8 1.0 0.2 -1.8 0.0 -2.5 -1.2
Supplements: Vitamin C 0.7 0.9 3.3 -0.2 -1.8 0.2 -0.2 -1.8 -1.7 0.0 -0.4 -0.5 0.3 -0.1 0.5
Knee pain experienced in last month 1.3 2.1 6.4 -0.0 -0.4 2.0 1.8 1.0 -0.1 2.5 -0.9 -1.2 2.1 -1.3 1.3
Hypertension (Self-reported) 1.0 2.8 6.4 -1.8 -2.0 1.1 1.6 -2.2 -2.5 -0.1 -0.1 -2.5 -0.1 -2.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.4 1.4 -0.2 1.1 0.3 1.1 1.1 1.9 -0.7 0.8 1.7 0.4 1.8
Illnesses of father: Heart disease 0.7 1.0 2.0 0.5 -0.3 -1.4 -1.2 -0.5 -1.2 -1.2 1.4 0.5 -1.1 -0.1 -1.0
Illnesses of siblings: Diabetes 1.1 1.3 3.3 -0.7 -0.4 1.5 1.5 0.5 -0.4 1.4 -1.0 -1.8 1.4 -1.2 -0.7
Smoking status: Previous 0.5 0.8 3.2 1.8 -0.1 -0.5 -1.2 0.6 -0.1 0.8 0.3 1.5 0.7 0.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.2 0.2 -1.8 0.9 0.3 -0.5 -1.2 -0.6 -1.2 0.1 -0.1 0.7 1.2
Whole body fat-free mass 0.6 3.6 13.3 1.2 -3.2 0.9 -0.4 -1.3 -2.2 0.6 0.5 -0.1 2.4 2.0 3.6
Leg fat-free mass (right) 0.3 1.6 5.6 0.5 -2.2 1.0 -0.0 -1.0 -1.6 0.4 0.3 -0.0 1.3 1.2 2.4
Arm fat percentage (left) 0.7 2.6 8.6 0.4 2.8 0.3 1.1 2.0 2.9 1.9 -1.4 -0.0 1.5 -0.4 0.8
Average weekly red wine intake 0.6 0.9 4.2 -0.3 -1.1 -0.8 -0.9 -2.0 -1.4 -1.1 0.5 0.1 -0.7 -0.1 -0.1
Handedness (chirality/laterality): Left-handed 2.1 2.5 6.0 -2.1 -2.5 1.7 1.6 -1.0 -1.7 0.3 -0.6 -2.0 -0.3 -2.2 -0.7
Mood swings 0.2 0.3 1.6 0.6 -1.3 0.3 -0.3 0.0 -0.3 0.3 -0.5 0.3 0.7 0.3 0.9
Loneliness, isolation 0.9 1.3 4.1 0.9 -0.3 -2.0 -1.5 0.0 0.8 -1.2 1.2 0.0 0.4 1.3 1.7
Long-standing illness, disability or infirmity 0.9 1.3 4.4 -1.7 0.1 1.3 1.4 0.7 0.2 0.1 0.2 -0.9 -1.1 -2.1 -1.5
Ever had bowel cancer screening 0.3 0.3 1.0 0.5 -0.1 -0.1 0.1 0.6 0.8 -0.2 -0.5 1.0 -0.4 0.2 0.8
Diabetes diagnosed by doctor 1.5 2.4 7.5 0.8 -0.2 1.7 1.4 2.0 1.6 2.0 -2.7 -0.4 2.2 -0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 4.8 0.9 2.0 -1.1 -0.1 1.5 2.2 1.2 1.4 0.6 0.9 0.2 -0.1
Friendships satisfaction 0.3 0.4 1.3 -0.8 -0.2 0.6 0.2 -0.0 -0.2 -1.1 -0.7 -0.4 -1.1 -0.7 -0.2
Qualifications: nursing, teaching 0.3 0.4 1.2 -0.8 -0.8 0.7 0.4 -0.9 -1.1 -0.4 0.0 -0.2 -0.8 -0.5 -0.4
Commuting to job workplace: Walk 0.5 0.6 3.2 0.4 1.8 0.6 0.6 0.7 0.9 0.7 -0.3 0.6 0.2 -0.1 0.9
Eye problems/disorders: Cataract 1.8 2.1 4.4 -1.2 1.9 0.7 2.1 1.8 1.5 1.4 1.5 -1.3 0.3 -1.8 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.1 -0.6 0.2 -1.2 -0.8 -0.8 -0.1 -2.2 0.8 0.7 -2.2 -0.1 -1.1
Medication for cholesterol 1.9 2.9 9.4 1.9 0.2 -3.1 -2.7 0.3 1.1 -1.4 0.1 2.2 -0.1 2.3 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.8 1.0 0.3 -0.3 -0.2 1.3 0.8 0.4 0.7 1.3 -0.0 0.4 0.4
Back pain experienced in last month 1.0 1.4 4.3 0.0 1.4 -2.1 -1.4 -0.3 0.8 -1.1 1.4 1.3 -1.6 0.1 -1.1
Mineral and other dietary supplements 1.3 1.7 4.7 -1.6 -0.6 2.2 1.8 -0.7 -0.7 0.1 -2.1 -1.3 -0.6 -1.5 -0.5
Breast cancer (self-reported) 2.5 3.0 10.2 0.4 2.2 0.2 0.9 2.8 3.2 1.9 0.1 -0.9 2.6 0.2 0.5
Asthma (self-reported) 0.2 0.4 1.2 0.7 -0.7 0.5 0.1 1.0 0.9 1.1 -0.6 0.3 0.7 -0.3 0.4
Osteoporosis (self-reported) 0.5 0.6 2.0 1.4 -0.1 -0.1 -0.9 -0.2 0.1 0.6 -0.5 1.1 0.9 1.0 0.9
Osteoarthritis (self-reported) 0.7 1.0 2.8 0.4 -0.6 1.7 0.9 0.7 -0.5 1.5 -1.5 -0.3 1.3 -0.4 0.1
Medication: Aspirin 1.5 1.9 5.0 -1.4 -0.1 2.2 2.2 0.9 0.7 1.1 0.1 -1.8 0.4 -2.2 -0.9
Medication: Gliclazide 0.3 0.4 0.8 -0.6 -0.9 0.4 0.3 -0.1 -0.4 0.2 -0.7 -0.8 0.5 -0.7 -0.9
Illnesses of father: None of the above (group 1) 0.5 0.7 2.4 -1.6 0.4 0.5 1.0 0.1 0.9 -0.0 0.8 -1.1 -0.3 -0.7 -0.9
Smoking status: Current 1.1 1.7 4.5 -1.9 0.2 1.6 1.9 0.1 -0.3 -0.1 -1.4 -1.3 -1.1 -2.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 8.6 -0.5 -0.5 -1.8 -1.6 -2.9 -1.4 -2.5 0.7 1.1 -2.3 1.5 -0.8
Whole body water mass 0.6 3.6 13.1 1.1 -3.3 0.9 -0.4 -1.3 -2.1 0.5 0.5 -0.2 2.4 2.0 3.6
Leg predicted mass (right) 0.3 1.6 5.6 0.5 -2.3 1.0 -0.1 -1.0 -1.6 0.4 0.3 -0.0 1.4 1.2 2.4
Arm fat mass (left) 0.5 2.0 5.3 0.8 1.4 0.6 0.7 1.5 2.0 1.8 -0.9 -0.1 2.3 0.5 2.1
Number of self-reported non-cancer illnesses 0.5 0.9 2.6 -0.0 -1.5 1.3 0.6 -0.2 -1.1 0.8 -1.6 -0.5 0.3 -1.2 0.7
Average weekly champagne plus white wine intake 0.3 0.4 1.4 -0.8 0.0 -0.1 0.8 -0.7 -0.1 0.2 -1.2 -0.5 -0.2 -1.0 -0.3
Miserableness 0.2 0.3 1.3 -0.4 0.1 0.4 0.7 0.5 0.3 0.6 -1.1 -0.1 -0.2 -1.0 -0.2
Guilty feelings 0.7 1.1 2.4 1.2 1.1 -0.4 -1.1 0.7 1.1 -0.0 -0.6 1.5 -0.1 1.5 1.4
Wears glasses or contact lenses 0.4 0.4 1.8 0.3 0.3 -1.3 -0.8 -0.1 0.7 -0.7 -1.1 0.3 -0.2 -0.0 -0.3
Ever taken oral contraceptive pill 0.7 0.8 2.5 -1.0 -0.3 1.4 0.9 0.2 0.4 -0.8 -1.6 -0.7 -0.7 -0.5 -1.3
Hearing aid user 1.9 2.2 6.5 0.3 2.6 -0.1 1.0 2.5 2.2 2.0 0.3 -0.3 1.0 -0.8 -1.3
Mother’s age at death 1.1 1.3 8.9 0.8 0.0 -3.0 -1.4 -1.3 -0.6 -0.6 0.6 0.8 0.1 0.8 0.5
Financial situation satisfaction 0.8 1.0 3.8 -1.1 0.7 0.9 1.3 1.0 0.1 0.6 0.0 -0.8 -0.5 -2.0 -1.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 3.2 0.4 0.9 0.4 0.6 1.7 1.8 1.0 -0.1 -0.1 1.0 0.4 0.6
Commuting to job workplace: Public transport 2.0 2.4 5.3 2.0 -1.3 1.6 -0.5 -0.4 -1.3 1.4 -1.7 1.2 1.9 1.8 2.3
Eye problems/disorders: Glaucoma 0.2 0.2 1.2 -0.2 0.1 -0.3 0.0 -0.7 -1.1 0.0 0.8 -0.3 0.0 -0.1 0.5
Medication: Blood pressure 1.3 2.4 5.0 -1.7 -0.5 2.1 2.2 -1.1 -1.8 1.3 0.7 -2.1 0.3 -2.1 0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.0 0.2 0.2 -0.5 -0.7 0.0 0.2 -1.0 -0.3 0.6 -0.6 -0.1 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 4.0 0.7 -0.2 -1.3 -1.2 -0.1 -0.1 -0.5 2.0 0.2 0.3 0.9 0.6
High cholesterol (Self-reported) 0.8 1.5 2.6 -1.5 -1.4 0.5 0.5 -1.5 -1.5 -1.4 -0.1 -0.9 -1.6 -1.3 -1.2
Medication: Bendroflumethiazide 0.9 1.3 5.4 -1.2 -0.7 -0.0 0.3 -2.3 -2.0 -0.9 0.0 -0.6 -1.4 -1.1 0.0
Medication: Paracetamol 1.1 1.7 7.2 1.5 1.8 0.3 0.3 1.2 0.6 1.2 -2.7 1.3 0.6 0.6 1.2
Medication: Lisinopril 0.8 1.0 4.0 0.3 -0.0 1.0 1.3 1.0 0.7 1.6 0.1 -0.2 1.0 -0.5 2.0
Medication: Atorvastatin 1.5 1.8 8.8 -0.6 -3.0 0.7 0.5 -1.1 -1.8 0.2 -1.3 -1.7 0.7 -0.9 -1.2
Illnesses of father: High blood pressure 0.7 0.9 3.3 -0.7 -1.2 0.8 0.4 -1.5 -1.8 -0.5 -1.0 -0.8 -0.1 -0.4 -0.2
Alcohol drinker status: Never 0.9 1.1 4.1 -1.3 -0.4 2.0 1.4 -0.3 -0.9 0.3 -0.9 -1.5 -0.1 -1.1 -0.5
Ever smoked 0.3 0.6 2.0 1.0 -0.2 -0.9 -1.3 -0.3 -1.0 -0.6 -0.0 1.4 -0.6 0.4 -0.3
Basal metabolic rate 0.5 3.0 13.2 1.3 -2.5 0.9 -0.3 -0.8 -1.4 0.8 0.4 0.0 2.5 2.0 3.6
Leg fat percentage (left) 0.7 2.5 7.0 1.1 2.5 -0.2 0.4 2.1 2.6 1.8 -0.9 0.0 2.2 0.4 1.4
Arm fat-free mass (left) 0.8 4.0 16.4 1.5 -3.0 0.9 -0.5 -1.0 -1.8 0.8 0.4 -0.3 3.0 2.4 4.0
Number of operations (self-reported) 1.0 1.4 3.2 1.1 1.3 0.5 0.3 1.2 1.8 1.4 -1.6 0.6 1.6 0.5 1.1
Average weekly beer plus cider intake 1.8 2.6 7.1 -2.2 -1.0 2.6 2.7 0.2 -0.4 -0.1 -1.3 -2.2 -0.7 -2.1 0.0
Irritability 0.3 0.6 2.2 -0.2 0.0 0.7 0.8 1.3 0.6 1.5 0.7 -0.3 0.6 -0.7 -0.2
Risk taking 0.2 0.3 1.0 -0.6 0.1 -0.6 -0.0 -1.0 -0.4 -0.8 -0.4 0.3 -0.9 -0.1 -0.6
Ever had prostate specific antigen (PSA) test 0.3 0.4 2.0 0.5 1.2 -1.4 -0.6 0.0 0.4 -0.3 0.3 0.3 -0.4 -0.3 -0.1
Fractured/broken bones in last 5 years 0.8 1.1 2.9 1.0 0.3 -1.4 -1.7 0.2 0.1 -0.5 1.2 1.6 -0.5 1.3 -0.8
Age started oral contraceptive pill 0.7 0.8 2.0 1.4 -0.3 -0.9 -1.3 0.2 -0.1 0.2 1.4 0.7 0.9 1.4 -0.0
Diastolic blood pressure, automated reading 0.3 0.8 2.1 1.1 1.1 -0.9 -0.7 -0.6 0.1 0.6 1.4 0.5 1.2 0.9 1.1
Ever depressed for a whole week 0.4 0.5 1.2 -0.7 0.9 0.9 0.7 0.9 1.1 0.2 -0.7 -0.1 -0.5 -0.5 -0.3
Unable to work because of sickness or disability 1.9 2.4 7.4 -2.6 -0.4 0.7 1.5 0.0 0.5 -1.2 -0.5 -1.3 -1.9 -2.2 -2.7
Commuting to job workplace: Cycle 1.1 1.3 3.8 -1.4 -0.7 0.3 0.4 -2.0 -1.6 -1.8 -0.4 -0.8 -1.5 -0.3 -0.9
Myopia 0.6 0.9 2.1 0.9 1.3 -1.1 -0.9 0.3 1.4 -0.6 -0.8 1.2 -0.4 1.4 -0.1
Vascular/heart problems diagnosed by doctor 1.1 3.1 6.8 2.1 1.9 -1.0 -1.6 2.4 2.6 0.1 -0.1 2.5 0.6 2.6 0.3
Cholesterol lowering medication 0.5 0.7 1.9 -0.6 -0.7 1.3 0.8 -0.6 -1.4 0.6 0.4 -1.0 0.2 -0.9 0.8
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.2 0.9 0.9 -0.2 -0.6 0.1 0.1 0.2 -0.5 1.8 -0.8 0.0 -0.0
Pain experienced in last month 0.3 0.5 1.8 -0.4 1.0 -0.3 0.3 0.9 1.3 -0.1 1.0 -0.7 0.0 -0.4 -0.6
Supplements: Calcium 0.3 0.3 1.3 -0.0 1.1 -0.2 -0.2 0.6 0.1 -0.6 1.1 0.4 -0.6 0.1 -0.2
Basal cell carcinoma (self-reported) 1.1 1.3 3.2 -0.8 -1.2 -0.9 -0.5 -1.6 -1.3 -1.5 1.8 -0.3 -1.2 0.1 -0.6
Heart attack/myocardial infarction (self-reported) 1.1 1.5 3.1 -1.1 1.3 0.8 1.6 1.3 1.7 0.6 -0.5 -1.6 0.3 -1.5 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.9 -0.8 0.5 -0.3 0.2 0.0 0.2 -0.8 1.4 -0.1 -1.1 -0.5 -0.6
Heart disease (siblings) 1.5 1.8 6.2 -1.5 -0.3 2.3 2.5 0.9 0.0 0.8 -1.0 -1.3 -0.2 -1.8 -0.2
Alcohol drinker status: Previous 1.5 1.7 6.1 -0.5 1.3 0.6 1.2 2.5 2.4 1.0 0.8 -0.3 -0.1 -1.3 -1.5
Pack years of smoking 0.3 0.4 1.4 -0.3 0.0 0.6 0.8 1.2 0.4 0.9 0.2 -0.1 0.6 -0.7 -0.5
Impedance of whole body 0.9 4.8 17.9 1.0 4.2 -0.6 0.2 3.9 4.2 1.2 -0.4 1.7 -0.4 -0.3 -0.6
Leg fat mass (left) 0.5 2.0 6.3 1.2 1.2 0.5 0.4 1.4 1.6 1.9 -0.9 0.1 2.5 0.8 2.2
Arm predicted mass (left) 0.8 4.2 17.7 1.8 -2.9 0.7 -0.7 -0.9 -1.8 0.8 0.8 0.1 2.9 2.5 4.2