Hub : Genes

TBC1D23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0960	0.0410	2.8e-03	0.090	NA	0.071	NA	0.084	2.8e-07	NA	5.0e-06	NA	7.6e-07
2	GTEx	Esophagus Mucosa	0.0540	0.0300	9.6e-03	0.007	NA	0.012	NA	0.015	1.1e-01	NA	5.1e-02	NA	3.2e-02
3	GTEx	Heart Atrial Appendage	0.1420	0.0600	2.7e-03	0.105	NA	0.093	NA	0.088	1.9e-05	NA	5.7e-05	NA	9.2e-05
4	GTEx	Muscle Skeletal	0.3602	0.0592	0.0e+00	0.248	NA	0.258	NA	0.260	3.4e-24	NA	3.1e-25	NA	2.0e-25
5	GTEx	Skin Sun Exposed Lower leg	0.0610	0.0260	6.5e-04	0.040	NA	0.051	NA	0.055	2.8e-04	NA	4.9e-05	NA	2.4e-05
6	GTEx	Stomach	0.0820	0.0410	5.8e-03	0.018	NA	0.013	NA	0.021	4.5e-02	NA	7.8e-02	NA	3.5e-02
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0807	0.0336	7.6e-08	0.093	0.088	0.084	NA	0.090	1.4e-10	4.6e-10	1.2e-09	NA	2.4e-10
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0595	0.0375	9.7e-03	0.013	0.003	0.009	NA	0.008	1.0e-02	1.5e-01	3.1e-02	NA	3.7e-02
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0630	0.0360	3.9e-03	0.021	0.025	0.027	NA	0.018	2.1e-02	1.4e-02	1.0e-02	NA	3.2e-02
10	TCGA	Pancreatic Adenocarcinoma	0.1430	0.0750	5.3e-04	0.102	0.072	0.058	NA	0.097	4.7e-05	6.0e-04	1.9e-03	NA	7.1e-05
11	TCGA	Prostate Adenocarcinoma	0.0361	0.0196	1.4e-03	0.002	0.015	0.011	NA	0.006	2.0e-01	8.6e-03	2.2e-02	NA	7.1e-02
12	TCGA	Thyroid Carcinoma	0.0890	0.0410	9.5e-05	0.022	0.036	0.037	NA	0.015	2.8e-03	1.8e-04	1.6e-04	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.9	1.4	6.7	1.4	0.4	-0.3	-0.2	0.2	0.2	1.0	0.6	0.3	1.9	1.4	2.6
Bipolar Disorder or Schizophrenia	0.5	1.2	5.9	1.3	-0.3	0.4	0.5	-0.2	-0.4	1.6	-0.3	0.3	2.0	0.6	2.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.8	1.0	0.5	-0.4	0.0	1.4	1.7	0.9	0.1	0.2	1.2	-0.0	1.4
Depression (Nagel 2018)	0.5	0.8	3.2	0.5	0.9	-0.7	-0.0	0.6	1.3	0.7	-1.8	-0.4	1.1	0.1	0.9
Intelligence (Savage-Jansen 2018)	1.8	5.6	16.2	3.7	1.3	-2.1	-3.1	-0.4	0.4	-0.3	0.4	3.4	1.0	4.0	3.0
Neuroticism (Nagel 2018)	1.1	2.5	7.1	2.7	1.1	-0.8	-1.1	1.8	1.8	1.4	-0.7	2.0	1.5	1.5	1.5
Schizophrenia (2018)	0.3	0.6	1.4	0.5	-0.7	0.7	0.7	-0.4	-0.6	1.2	-0.9	0.2	1.0	-0.4	1.0
Schizophrenia vs Biploar Disorder	1.5	2.0	8.6	-1.7	-0.2	-0.5	-0.2	-0.9	-0.5	-1.8	0.7	-0.2	-2.5	-1.0	-2.9
Worry (Nagel 2018)	0.7	1.5	4.2	1.9	0.0	-1.9	-2.0	-0.1	0.0	-0.3	-0.3	2.0	0.1	1.7	0.3
Alzheimer’s Disease (in mother)	0.4	0.4	2.0	-0.2	-0.2	-0.8	-0.5	-1.4	-0.9	-0.5	0.6	-0.4	0.0	0.3	0.5
Alzheimer’s Disease (in father)	0.5	0.5	2.2	-0.8	0.8	-0.0	0.5	0.6	1.3	-0.4	-0.4	-0.3	-0.2	-0.3	-1.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	-0.7	0.4	-0.5	-0.1	-0.5	0.0	-0.6	0.0	-0.5	0.0	-0.2	-0.7
Crohns Disease (2017)	0.9	2.0	5.3	0.8	2.1	1.2	1.1	2.1	2.3	1.1	-1.4	1.2	0.4	-0.1	1.3
Irritable Bowel Disease (IBD)	1.0	2.5	9.6	1.2	2.4	0.3	0.7	2.4	3.1	1.2	-0.8	1.0	1.1	0.5	1.4
Ulcerative Colitis (UC)	0.8	1.5	6.5	1.1	1.6	-0.6	0.2	1.5	2.6	0.9	0.0	0.2	1.4	0.9	1.3
Major Depression (MDD)	0.9	1.1	4.3	-1.2	-0.9	0.7	1.0	-1.1	-1.2	0.1	-1.2	-2.1	1.0	-0.8	-0.2
Reaction Time	1.0	1.8	4.7	2.2	0.6	-0.9	-1.1	0.7	1.0	0.9	-1.2	1.6	1.5	1.8	1.8
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.0	1.6	0.4	-0.7	-1.3	0.1	0.6	-0.2	0.4	1.7	0.2	1.7	1.5
Breast Cancer	3.3	8.0	28.1	-2.6	-4.8	1.3	-0.1	-3.4	-5.3	-2.0	1.4	-1.7	-2.5	-2.3	-2.2
Ovarian Cancer	1.9	2.5	4.6	0.2	-2.1	-1.3	-1.9	-2.2	-2.0	-1.8	1.3	1.5	-1.8	0.7	0.2
Prostate Cancer	0.3	0.4	1.6	0.1	0.6	0.1	-0.1	0.8	1.2	-0.2	1.1	-0.2	0.4	0.7	0.1
Age at First Birth	0.5	0.8	2.3	0.3	0.0	-0.7	-0.9	-0.5	-0.2	-1.1	-0.2	1.5	-1.1	1.5	0.6
Bipolar Disorder (2011)	1.8	1.7	6.4	1.4	-1.1	0.3	-0.5	-1.3	-1.6	0.4	-1.3	0.8	1.2	1.6	2.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	-0.1	1.0	0.5	1.0	1.5	1.0	1.3	-0.2	-0.1	0.4	-0.7	-0.3
Coronary Artery Disease (CAD)	1.8	2.1	7.8	0.8	-0.2	-2.8	-1.9	-1.1	-0.1	-2.3	1.1	1.2	-1.3	1.6	0.4
Crohns Disease (2012)	1.6	2.5	6.1	1.6	1.7	1.4	0.9	1.7	1.7	1.4	-2.5	1.1	1.6	0.9	1.9
Mean Putamen Volume	0.3	0.3	1.3	-0.2	0.6	-0.2	-0.3	0.8	0.5	-0.3	0.6	0.1	-0.6	-0.1	-1.1
Fasting Glucose	0.4	0.5	1.3	0.5	0.0	-0.1	-0.9	-0.9	-0.5	-1.0	0.2	0.4	-0.3	1.1	1.1
HbA1C	0.6	0.7	3.2	-1.4	-0.0	-0.3	0.7	0.2	0.5	-0.1	-0.7	-0.6	-1.1	-0.8	-1.8
HDL Cholesterol	0.6	1.0	4.7	0.3	-0.8	0.4	0.6	-0.3	0.2	0.1	-1.7	-0.1	1.5	0.9	2.2
LDL Cholesterol	1.2	1.9	5.6	1.3	-0.5	-1.8	-2.4	-1.2	-1.2	-1.2	0.8	2.0	-1.0	1.3	0.2
Lupus	1.5	2.3	9.3	-0.2	-2.2	-0.6	-1.0	-2.9	-3.0	-1.3	0.3	0.2	-1.1	0.6	-0.5
Neuroticism (2016)	0.9	1.2	6.1	1.5	0.6	-0.3	-0.2	1.0	1.2	0.5	0.7	0.8	1.1	1.0	2.5
Primary Biliary Cirrhosis	2.7	3.9	10.5	3.2	1.1	-1.3	-1.7	0.7	1.4	1.2	-0.8	2.6	1.9	2.8	2.9
Rheumatoid Arthritis	0.5	0.7	1.9	0.5	-1.0	0.8	-0.1	-0.8	-1.2	0.7	-0.8	-0.0	0.9	0.7	1.4
Schizophrenia (2014)	0.2	0.5	1.7	0.9	-0.4	0.6	0.2	-0.2	-0.2	0.9	-1.3	0.7	1.1	0.3	0.7
Triglycerides	1.2	1.9	4.3	-0.5	-1.3	-1.3	-1.0	-1.1	-1.7	-1.3	2.1	0.5	-1.9	-0.7	-1.9
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.0	-0.7	-0.9	0.8	0.5	-1.7	-1.6	-0.6	-0.7	0.1	-1.0	-0.3	0.7
Ulcerative Colitis	0.5	0.7	2.1	1.0	1.3	-0.5	-0.1	0.5	1.5	0.3	-0.0	0.2	1.0	1.1	1.0
Blood Eosinophil Count	0.1	1.0	2.8	1.4	0.5	0.7	-0.6	1.2	0.2	1.7	0.4	0.4	1.5	0.7	1.3
Blood Platelet Count	0.1	1.4	5.8	0.2	-1.1	2.4	1.2	0.9	-0.1	1.7	-0.2	-1.1	1.8	-0.3	0.4
Blood Red Count	0.1	0.9	3.2	-0.8	-0.5	1.0	1.5	0.3	-0.3	1.4	-0.0	-1.0	0.5	-1.8	-0.0
Blood White Count	0.3	2.3	9.5	0.1	2.1	0.9	1.3	2.7	3.1	1.6	-1.0	-0.1	1.0	-0.3	0.2
Heel T-Score	0.8	6.4	23.5	-1.1	-1.8	-1.0	-1.5	-4.8	-4.8	-2.8	-1.0	0.6	-3.1	-0.4	-1.8
BMI	0.2	1.0	3.0	0.3	1.4	-0.3	0.7	0.9	1.7	1.3	-0.0	-0.4	1.4	-0.2	1.1
Height	0.4	8.1	24.2	3.6	-0.9	-0.0	-0.6	3.8	1.8	2.9	2.7	1.1	4.3	2.5	4.9
Waist Hip Ratio (WHR)	2.1	9.5	39.2	2.2	3.5	0.8	-0.2	6.0	6.3	3.0	1.1	1.9	2.5	1.0	0.3
Systolic Blood Pressure	2.3	11.3	23.4	-4.8	-2.5	3.2	3.9	-2.9	-4.3	-0.5	-0.4	-4.4	-1.9	-4.8	-2.7
Smoking Status	0.1	0.3	1.0	-0.6	0.1	0.5	0.4	0.2	0.1	0.0	-1.0	-0.6	0.0	-1.0	-0.4
Allergy or Eczema	0.2	0.5	1.9	-0.7	-1.3	0.1	-0.0	-0.6	-1.0	-0.5	0.6	-0.4	-0.4	-0.4	-1.4
Cardiovascular Disease	1.3	4.4	9.1	-2.6	-2.5	1.6	1.9	-2.9	-3.0	-0.5	-0.8	-3.0	-0.5	-2.3	0.8
Hypothyroidism (self reported)	0.6	1.4	3.3	-1.1	-1.3	1.8	1.3	-0.4	-1.4	0.7	-0.2	-1.7	-0.1	-1.8	0.2
Respiratory disease	1.0	2.3	7.6	0.4	0.4	1.6	1.4	2.8	2.5	2.2	-1.0	-0.1	1.2	-1.1	0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.5	1.9	-1.6	0.1	-1.0	0.1	-0.0	0.6	-0.9	0.8	1.6	1.4	1.1
Lung FEV1/FVC ratio	0.3	1.7	7.5	1.1	-2.2	-0.2	-1.1	0.0	0.2	-0.9	1.1	0.2	1.1	2.7	1.6
Lung FVC	1.6	8.2	28.7	-1.5	1.0	-3.0	-1.9	-5.4	-3.7	-3.7	1.3	1.1	-4.5	0.3	-1.9
Neuroticism	0.4	1.0	3.0	1.3	-0.2	-1.4	-1.7	-0.0	0.6	-0.3	0.3	1.6	0.1	1.2	0.8
Chronotype (morning person)	0.2	0.4	1.3	0.3	-0.9	-0.3	-0.5	-1.0	-0.4	-0.3	0.1	-0.3	0.4	1.2	1.0
Hair Pigment	0.1	2.9	10.4	1.6	2.9	-0.5	0.6	1.4	2.1	1.8	-0.3	0.7	1.7	0.6	3.2
Tanning	0.2	2.1	6.4	-1.1	1.2	1.1	1.8	2.5	2.3	1.0	0.5	-1.0	0.4	-1.7	-1.3
Hand grip strength (left)	0.7	1.7	7.4	0.0	-2.7	-0.0	-0.7	-1.6	-1.5	-0.8	1.1	-0.8	0.9	1.5	1.5
Number of treatments/medications taken	0.3	0.5	1.4	0.3	0.5	1.0	0.9	0.6	0.2	1.2	-0.5	-0.6	0.8	-0.7	0.8
Average weekly spirits intake	0.5	0.6	3.8	-0.6	-1.0	2.0	1.1	0.2	0.0	0.1	-0.8	-0.5	0.3	0.1	0.5
Sensitivity / hurt feelings	1.0	1.7	4.0	2.0	1.1	-0.1	-0.6	1.6	1.5	1.5	-1.3	1.4	1.3	0.9	1.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	-0.2	0.6	-0.3	-0.2	-0.1	0.9	-0.1	-0.7	-0.5	0.1	-0.3	-0.2
Hearing difficulty/problems: Yes	1.7	2.5	10.9	0.2	3.3	-1.7	-0.2	1.7	2.1	0.6	0.7	1.0	-0.9	-1.3	-2.2
Relative age of first facial hair	0.3	0.7	1.9	-1.3	-0.5	0.8	1.4	-0.7	-1.0	0.3	0.1	-1.3	-0.3	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.7	1.0	-0.2	0.4	-0.7	-0.5	-1.0	0.2	-0.4	1.4	0.0	1.1	1.9
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.9	1.2	0.4	1.4	0.5	1.2	0.8	1.7	-0.1	0.2	1.6	0.5	1.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.5	-0.2	0.5	1.2	0.9	1.5	1.0	1.5	-1.6	-0.1	0.8	-0.9	-1.1
Systolic blood pressure, automated reading	0.9	2.8	7.1	-1.9	-0.5	1.4	2.0	-1.6	-2.4	0.8	-0.4	-1.7	-0.3	-2.7	-2.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.0	-0.0	-0.5	-0.7	-0.2	-0.5	-0.1	-0.8	-1.0	-0.4	-0.3	0.0	-0.5
Angina	2.4	3.1	7.7	-2.2	-1.3	2.0	2.7	-0.4	-1.1	0.9	-1.2	-2.8	0.6	-2.4	-1.5
Medication for hormone replacement therapy	0.4	0.5	2.1	0.0	-0.2	1.1	0.2	0.3	0.4	-0.1	0.3	-0.6	0.9	0.9	1.4
Vitamin and mineral supplements	1.3	1.8	5.8	-1.6	1.3	0.5	1.6	1.2	1.4	0.3	0.8	-0.8	-1.4	-2.4	-1.3
Supplements: Zinc	1.2	1.3	5.6	0.5	1.9	0.0	0.1	2.1	2.4	0.8	0.4	0.5	0.3	0.1	-1.0
Medication: Co-codamol	1.4	1.6	5.0	-1.6	0.5	-1.1	0.1	-0.5	-0.1	-1.8	0.5	-0.9	-2.2	-1.3	-2.2
Medication: Metformin	1.1	1.5	4.2	1.2	0.1	1.2	0.6	2.0	1.6	1.5	-1.9	0.7	1.4	0.1	-0.1
Diabetes (father)	0.8	0.9	4.1	1.2	2.0	0.1	-0.3	0.7	0.7	0.9	-1.2	1.0	0.7	0.6	0.8
Diabetes (mother)	2.4	3.1	6.5	2.5	2.0	-2.1	-2.0	0.5	1.4	0.4	1.6	2.5	0.4	2.0	1.8
Severe depression (siblings)	0.2	0.2	0.7	-0.5	0.1	0.3	0.5	-0.1	0.2	-0.1	-0.6	-0.7	0.4	-0.0	0.8
Pack years adult smoking proportion	0.4	0.6	1.5	-0.7	-0.4	1.2	1.2	1.1	0.3	1.0	-0.1	-0.5	0.7	-0.8	-0.4
Impedance of leg (right)	0.6	3.0	10.8	1.6	2.8	-0.8	-0.4	3.1	3.3	1.1	-0.1	1.3	0.7	0.9	0.6
Leg fat-free mass (left)	0.3	1.8	7.5	0.9	-2.0	1.1	-0.1	-0.6	-1.2	0.7	0.0	0.1	1.8	1.5	2.7
Trunk fat percentage	1.3	5.1	20.0	1.1	4.0	0.1	0.8	3.8	4.5	2.1	-1.1	0.7	1.7	0.1	1.1
Hand grip strength (right)	0.5	1.5	6.3	1.1	-1.1	0.6	-0.5	-0.3	-0.2	0.2	-0.2	0.2	1.8	2.2	2.5
Townsend deprivation index at recruitment	0.7	1.0	3.3	-0.5	1.3	0.3	1.0	1.8	1.8	0.8	0.7	-0.3	0.1	-1.0	-0.7
Current tobacco smoking	1.0	1.6	4.0	-2.0	0.2	1.4	1.7	-0.2	-0.2	-0.5	-1.3	-1.3	-1.3	-2.0	-1.0
Average weekly fortified wine intake	0.4	0.4	1.2	0.8	0.8	-0.8	-0.8	0.6	0.5	0.5	0.2	0.7	-0.1	-0.3	-1.1
Maternal smoking around birth	0.2	0.3	0.9	0.0	-0.9	0.6	0.1	-0.3	-1.0	-0.4	-0.5	0.1	-0.5	-0.3	-0.0
Fed-up feelings	1.0	1.8	8.8	0.4	1.8	-0.0	0.6	2.5	3.0	1.4	-0.3	0.1	0.7	-0.8	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.0	-1.5	0.8	0.3	1.2	0.6	0.9	0.3	-1.5	-1.5	-0.1	-1.7	-1.7
Relative age voice broke	0.3	0.4	0.9	-0.7	-0.6	0.5	1.0	-0.2	-0.9	0.3	0.6	-0.6	-0.4	-0.8	-0.6
Taking other prescription medications	0.4	0.6	2.1	-1.0	-0.8	1.2	0.7	0.1	-0.4	-0.1	-0.2	-1.0	-0.4	-1.4	-0.4
Age when periods started (menarche)	2.2	5.4	14.2	-3.8	-0.6	2.0	2.1	-1.4	-1.5	-2.2	-0.9	-1.8	-3.5	-3.1	-2.6
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	6.4	2.5	1.6	0.4	-1.0	2.0	1.7	1.5	-1.4	1.8	1.6	1.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.9	0.2	-0.1	-0.2	-1.1	-2.0	-1.8	-0.8	-0.7	0.7	-0.5	0.8	-0.3
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	9.8	-1.0	-2.7	1.2	-0.5	-2.1	-3.1	-0.9	1.3	-0.7	-0.7	-0.1	0.2
Qualifications: CSEs or equivalent	0.4	0.5	2.7	0.3	-0.1	-0.8	-0.3	-0.6	-0.4	-0.6	-1.7	-0.1	0.5	0.6	0.9
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.1	-0.4	0.5	0.0	-0.2	-0.7	-0.1	-0.9	-0.3	0.8	0.5	0.8
High blood pressure	1.0	2.8	6.1	-2.0	-1.6	1.1	1.7	-2.2	-2.5	-0.0	-0.3	-2.4	-0.5	-2.5	-0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	0.1	-0.5	-1.1	-1.1	-0.6	-0.3	-1.2	1.0	0.7	-0.8	0.8	-0.6
Multivitamins +/- minerals	0.7	0.9	4.0	1.3	-0.7	-0.2	-1.1	-0.3	-0.6	0.1	0.2	0.6	1.3	2.0	1.0
Stomach or abdominal pain in last month	0.3	0.4	1.4	-0.5	1.1	-0.5	0.2	-0.1	0.4	-0.4	0.2	0.5	-1.2	-0.8	-0.6
Supplements: Glucosamine	1.1	1.5	4.8	2.2	0.0	-1.4	-1.3	0.8	0.2	0.7	1.0	1.6	1.2	1.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	0.7	-0.4	0.2	0.1	0.0	0.5	1.1	1.4	0.2	1.3	0.7	1.2
Medication: Atenolol	2.4	3.0	7.2	-2.7	-1.7	1.4	1.8	-1.8	-1.8	-0.8	-1.4	-2.5	-0.5	-1.9	-1.1
Medication: Levothyroxine sodium	1.4	2.4	5.5	-2.0	-2.4	1.2	0.8	-1.8	-1.8	-0.6	-0.1	-2.2	-0.8	-1.7	-1.2
Sitting height	0.1	0.9	4.5	0.8	-1.1	1.2	0.1	0.6	-0.7	0.5	-0.3	1.0	0.3	0.7	2.1
Chronic bronchitis/emphysema (father)	1.7	2.0	9.6	0.8	0.9	0.1	1.0	3.1	2.7	1.8	-0.6	0.4	1.1	-0.4	-0.1
High blood pressure (mother)	1.3	1.9	5.3	-0.4	-2.3	0.9	0.0	-2.2	-2.2	-0.9	-2.0	-0.4	0.1	0.5	1.1
Body mass index (BMI)	0.2	0.9	3.3	0.4	0.6	0.6	0.6	0.5	0.9	1.2	-1.1	-0.4	1.8	0.3	1.3
Impedance of leg (left)	0.6	2.7	9.9	1.3	3.0	-0.9	-0.5	3.0	3.1	0.7	0.1	1.3	0.2	0.5	0.3
Leg predicted mass (left)	0.3	1.8	7.8	0.9	-2.0	1.0	-0.1	-0.6	-1.2	0.8	0.0	0.2	1.9	1.5	2.8
Trunk fat mass	0.8	3.5	10.1	1.4	2.5	0.3	0.5	2.8	3.2	2.0	-0.9	0.6	2.3	0.7	2.1
Waist circumference	1.6	6.0	19.5	1.8	3.7	0.1	0.6	3.9	4.4	2.9	-0.5	0.4	3.1	0.6	1.3
Number of incorrect matches in round	0.2	0.3	1.8	0.5	0.1	-0.2	-0.6	-0.6	-1.3	0.0	-0.6	0.7	-0.3	-0.1	-0.5
Past tobacco smoking	0.4	0.7	2.7	-1.6	0.2	0.3	1.1	-0.6	0.7	-1.0	-0.0	-1.5	-0.6	-0.3	-0.1
Alcohol usually taken with meals	0.7	1.1	5.6	-0.4	-0.4	-1.3	-0.9	-2.4	-1.5	-1.3	0.4	0.2	-0.9	0.4	-0.2
Nervous feelings	0.2	0.3	1.0	0.7	0.3	-0.2	-0.5	0.0	0.2	0.3	-1.0	1.0	0.2	0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.7	0.6	0.4	0.5	0.0	0.5	-0.2	-1.4	0.0	-0.7	-0.5	-1.4
Hearing difficulty/problems with background noise	1.5	2.5	7.2	-0.2	0.6	-2.4	-1.8	-1.1	-0.3	-2.7	1.8	1.2	-2.5	0.3	-1.0
Hair/balding pattern: Pattern 2	0.8	1.0	4.8	0.4	-0.4	0.8	0.3	0.3	0.1	2.1	0.2	-1.0	2.2	0.0	1.0
Had menopause	1.0	1.3	4.3	1.3	1.4	-0.7	-0.3	1.4	0.6	2.1	0.6	0.7	1.6	-0.2	-0.9
Had other major operations	2.0	2.5	8.5	0.7	-0.1	1.8	1.0	1.0	1.1	2.1	-2.3	-1.0	2.9	0.7	1.6
Forced vital capacity (FVC)	0.6	2.3	6.1	0.3	0.0	-1.2	-1.2	-2.5	-2.0	-1.8	1.4	1.2	-1.7	1.7	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	3.0	-0.2	-0.2	0.6	-0.1	-1.3	-1.1	-0.3	-1.7	0.2	-0.3	0.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.4	-1.8	0.2	1.3	1.7	0.5	0.9	0.0	-0.5	-1.4	-0.2	-1.0	-0.9
Qualifications: None of the above	0.3	0.7	2.4	-0.3	0.7	1.0	0.8	1.1	0.2	1.0	-0.4	-0.1	-0.4	-1.6	-1.1
Financial difficulties in last 2 years	2.0	2.7	5.4	-2.0	-1.1	-0.4	-0.5	-2.3	-2.0	-2.2	1.1	-0.7	-2.2	-1.2	-2.3
Mouth/teeth dental problems	1.0	1.5	4.9	1.5	0.4	-1.9	-1.7	-0.1	0.8	-0.9	0.3	1.4	0.5	2.2	0.8
Heart attack	1.2	1.6	3.1	-1.0	1.4	0.8	1.6	1.5	1.8	0.8	-0.2	-1.6	0.4	-1.6	-1.3
Allergy	0.2	0.4	1.0	0.1	0.6	0.3	0.5	-0.4	-0.2	0.5	-0.9	-0.6	0.9	0.3	1.0
Pain all over the body in last month	0.4	0.4	1.3	0.3	0.1	-0.7	-0.7	-0.2	-0.5	-0.5	-1.1	0.9	-0.4	0.6	-0.8
Diabetes (self-reported)	0.7	1.1	3.2	0.8	-0.3	0.9	0.7	1.3	1.5	1.1	-1.8	-0.0	1.6	0.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.5	1.3	0.3	-1.1	-1.1	0.1	-0.3	0.2	-1.1	1.9	0.0	0.6	0.7
Medication: Ramipril	0.9	1.2	2.2	-0.5	0.9	0.8	1.5	0.8	0.5	1.4	-0.8	-1.5	0.9	-1.5	-1.2
Medication: Simvastatin	0.4	0.6	1.6	-1.3	-0.0	0.6	0.6	-0.2	-0.1	-0.9	0.2	-0.7	-1.2	-1.2	-0.3
Fluid intelligence score	0.3	0.6	1.3	0.7	0.5	-0.5	-1.1	-0.9	-0.3	-0.8	0.4	0.9	-0.5	1.0	1.1
Illnesses of siblings	1.5	2.1	6.4	2.2	0.3	-1.4	-2.2	0.4	0.8	0.3	1.1	1.4	1.2	2.5	1.3
Neuroticism score	0.2	0.4	0.7	0.8	0.2	-0.8	-0.8	0.5	0.7	0.3	-0.1	0.9	0.3	0.3	0.6
Weight	0.4	2.1	9.4	1.5	-0.1	0.6	0.1	0.8	0.7	1.5	-0.3	0.2	2.7	1.5	3.1
Impedance of arm (right)	1.0	4.6	18.3	0.1	4.3	-0.5	0.8	3.5	4.2	0.9	-0.7	1.0	-0.8	-0.9	-1.5
Arm fat percentage (right)	0.7	2.9	10.7	0.6	3.1	0.2	1.0	2.3	3.3	1.9	-1.1	0.0	1.7	-0.3	0.7
Trunk fat-free mass	0.9	5.2	17.3	1.6	-4.0	0.7	-0.8	-1.9	-2.8	0.4	1.0	-0.1	2.6	2.5	4.2
Hip circumference	0.5	2.1	5.2	1.0	2.0	0.1	0.8	1.4	1.9	1.7	-1.1	-0.3	2.3	0.7	2.0
Time employed in main current job	0.2	0.3	1.5	0.4	-0.2	-0.0	-0.1	0.1	0.0	0.2	0.5	-0.5	0.9	0.3	1.2
Alcohol intake versus 10 years previously	1.7	2.6	8.3	1.0	0.6	1.0	0.9	2.2	2.0	2.5	-1.0	-0.6	2.9	0.5	1.7
Father’s age at death	1.2	1.6	4.3	1.8	0.4	-0.0	-0.2	1.1	1.6	1.7	-0.0	0.9	2.1	1.3	1.4
Worrier / anxious feelings	1.0	1.9	4.8	2.1	0.5	-0.9	-1.0	1.0	0.9	1.4	-0.8	0.9	2.2	1.7	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.2	-0.0	0.7	0.7	0.2	0.6	0.8	0.7	-1.5	-0.1	0.5	0.0	-0.0
Falls in the last year	1.4	1.8	6.5	0.2	2.5	-0.6	0.3	2.2	2.0	1.0	-0.7	1.1	-0.4	-1.2	-1.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.7	0.3	1.3	-0.5	-0.1	0.7	0.9	-0.1	0.1	1.1	-0.9	-0.8	-0.5
Number of live births	3.3	4.7	11.8	-3.3	-1.2	2.1	2.4	-1.2	-1.3	-0.4	-0.3	-3.0	-1.6	-3.4	-2.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.1	1.1	-0.5	-1.0	-1.6	-2.2	-1.9	-1.5	0.8	1.6	-0.9	2.5	1.9
Pulse rate	1.1	1.9	5.8	1.3	-0.0	0.8	0.4	2.4	2.1	1.8	0.2	0.5	1.9	0.7	1.4
Happiness	0.1	0.2	0.4	0.0	-0.4	0.5	0.3	0.5	0.4	0.5	-0.4	-0.4	0.6	-0.4	0.1
Noisy workplace	1.4	1.7	3.2	-1.2	1.6	-0.3	1.2	1.8	1.7	0.2	1.4	-0.2	-1.3	-1.8	-1.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	0.8	-0.1	-1.3	-1.5	-0.8	0.3	-1.2	0.1	1.0	-0.2	1.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.4	0.6	-0.5	-0.6	0.3	0.6	-0.3	0.3	0.2	0.1	0.5	0.6
Mouth/teeth dental problems: Dentures	1.3	2.3	5.1	-0.9	0.2	2.3	2.3	1.4	0.4	2.1	0.3	-2.1	1.2	-1.9	0.3
Asthma	0.3	0.6	1.8	0.7	-0.5	0.3	0.0	1.4	1.1	1.3	-0.3	0.4	0.8	-0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.5	0.5	0.8	-1.5	-1.6	-0.5	0.7	-1.2	1.0	1.1	-0.5	1.9	0.2
Medication: Cholesterol lowering	0.7	1.1	3.3	-1.0	-1.7	0.2	0.3	-0.3	-0.7	-1.1	-0.8	-0.9	-0.9	-1.4	-1.8
Depression (self-reported)	1.0	1.2	3.1	-0.5	1.2	0.2	1.0	0.7	0.6	1.4	-1.8	-0.6	0.4	-1.7	-1.6
Medication: Lansoprazole	2.2	2.5	7.5	2.0	1.1	1.1	0.4	2.2	1.5	2.7	-0.4	1.0	2.0	0.5	1.8
Prospective memory result	1.0	1.2	4.6	1.0	1.0	-0.2	0.1	1.8	2.2	1.5	0.3	0.9	1.1	0.5	0.3
Lung cancer (father)	0.6	0.7	3.6	0.0	0.4	-1.4	-0.9	0.0	0.3	-0.9	1.9	0.2	-0.9	0.1	-0.3
Illnesses of mother	0.5	0.6	2.4	-0.2	0.5	-0.6	-0.4	1.4	1.1	-0.0	0.9	-0.0	-0.4	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.2	0.9	-0.4	-1.4	-1.7	-2.3	-1.6	-2.1	-0.1	1.8	-1.4	2.5	1.3
Pulse wave Arterial Stiffness index	0.4	0.5	2.2	-0.7	0.2	-0.0	-0.2	-0.2	-0.2	-0.7	1.4	0.2	-1.5	-0.5	-0.8
Impedance of arm (left)	1.0	4.5	17.9	0.2	4.2	-0.6	0.6	3.4	4.2	0.9	-0.7	1.3	-1.0	-0.9	-1.4
Arm fat mass (right)	0.5	2.2	7.1	1.1	1.3	0.5	0.7	1.6	2.0	2.0	-0.9	-0.2	2.7	0.6	2.1
Trunk predicted mass	0.9	5.4	18.6	1.7	-3.9	0.5	-0.9	-1.9	-2.8	0.4	1.1	0.0	2.6	2.6	4.3
Standing height	0.5	4.5	19.6	2.7	-1.9	0.1	-1.2	0.8	-0.2	1.0	1.5	1.4	2.6	3.1	4.4
Length of working week for main job	0.3	0.4	1.5	0.2	1.1	0.2	-0.1	1.2	0.9	0.3	0.4	0.5	0.0	0.2	-0.4
Exposure to tobacco smoke at home	0.2	0.2	0.9	-0.2	0.3	-0.8	-0.5	-0.3	-0.5	-0.1	-0.1	-0.2	-0.0	-0.2	-0.9
Breastfed as a baby	0.4	0.4	2.3	0.0	-0.2	-1.5	-0.8	-0.5	0.2	-0.7	0.9	0.1	-0.5	-0.1	-0.7
Tense / ‘highly strung’	0.4	0.7	1.8	0.6	-1.3	-0.6	-1.3	-0.8	-0.8	-0.4	1.3	0.7	-0.0	1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.5	-1.4	1.3	0.0	0.8	1.2	1.6	-0.3	1.0	-0.2	-1.3	-1.4	-1.3
Hair/balding pattern: Pattern 4	0.5	1.1	4.0	0.8	-2.0	-0.0	-0.9	-0.9	-1.4	-0.7	-0.7	0.7	0.2	1.4	1.4
Birth weight of first child	0.6	1.0	2.9	0.7	0.8	-1.5	-1.7	0.3	0.2	-1.1	1.4	1.0	-0.6	0.8	-1.0
Peak expiratory flow (PEF)	1.3	3.0	5.8	1.1	-0.4	-1.7	-2.4	-1.8	-1.3	-2.2	1.6	1.7	-1.5	2.4	1.5
Pulse wave reflection index	1.9	2.3	7.7	-0.5	-0.2	-0.6	-1.5	-2.0	-1.9	-2.1	1.8	1.0	-2.8	0.4	-0.8
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.9	-2.2	-0.5	1.5	1.5	-0.2	-0.5	-0.9	-1.2	-1.1	-1.3	-1.1	-2.0
Loud music exposure frequency	1.7	1.8	6.8	0.1	-2.6	1.1	-0.6	-1.8	-2.2	-1.0	-1.0	0.7	-0.6	1.0	1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	0.5	-0.1	-1.1	-0.8	-0.1	0.6	-0.4	0.5	-0.0	0.7	1.0	0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.8	-1.4	-0.6	1.1	0.4	-0.5	-0.8	-0.5	-2.2	-0.2	-1.3	-1.3	-1.8
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.8	0.4	-0.2	0.2	0.0	0.3	-0.9	1.2	-0.4	-0.9	-0.4	-0.3
Medication: Paracetamol	0.7	1.1	5.1	1.5	0.6	0.4	-0.0	0.8	0.4	1.0	-2.3	1.3	0.7	0.8	1.0
Headache pain in last month	0.6	1.1	3.6	0.3	-1.2	0.7	-0.4	-1.6	-1.9	-0.4	-1.4	1.0	-0.8	0.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.9	0.6	1.2	0.2	-0.5	0.4	0.7	0.5	0.8	1.4	-0.0	1.3	0.6
Glaucoma (self-reported)	0.9	1.1	3.0	-0.8	-0.0	-1.1	-0.7	-1.3	-1.2	-1.4	1.7	-0.0	-1.4	-0.0	-0.8
Gout (self-reported)	1.4	1.9	4.2	-2.0	-1.8	0.4	0.3	-1.1	-1.2	-1.5	-0.4	-1.7	-1.2	-1.5	-2.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.4	-1.8	-1.6	1.2	1.1	-1.0	-1.5	-0.2	-0.5	-2.1	-0.7	-1.7	-0.6
Medication: Amlodipine	0.5	0.7	1.7	-0.9	-0.7	0.0	0.7	-1.1	-0.9	-0.1	1.3	-1.2	0.0	-0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.5	-0.5	-0.5	-0.7	-0.3	0.2	-0.2	-0.1	0.2	0.5	0.7	0.7
Birth weight	0.4	0.9	2.0	-0.9	-0.0	1.4	1.1	1.0	1.3	0.3	1.1	-1.3	0.6	-0.0	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.7	0.5	-0.3	1.6	1.0	0.4	-0.4	1.6	-1.1	0.0	1.3	-0.5	0.9
High blood pressure (siblings)	0.8	1.1	3.3	-1.2	0.1	0.1	0.7	-0.9	-0.9	-1.0	-1.1	0.2	-1.8	-1.4	-1.5
Forced vital capacity (FVC), Best measure	0.7	2.5	4.7	0.6	0.5	-1.6	-1.5	-2.1	-1.3	-2.1	0.4	2.1	-2.2	1.8	0.9
Body fat percentage	1.1	4.2	15.7	1.0	3.7	-0.0	0.7	3.2	4.0	2.0	-1.1	0.5	1.7	-0.0	1.0
Leg fat percentage (right)	0.8	3.0	8.8	1.3	2.7	-0.2	0.4	2.3	3.0	2.0	-0.8	0.2	2.4	0.6	1.5
Arm fat-free mass (right)	0.8	4.3	17.3	1.6	-3.3	1.0	-0.6	-1.3	-2.2	0.7	0.2	0.1	2.7	2.3	4.2
Exposure to tobacco smoke outside home	0.2	0.3	1.1	0.1	0.9	-1.0	-0.7	-0.4	0.4	-0.6	-0.7	0.1	-0.3	0.3	-0.5
Comparative body size at age 10	0.4	1.2	4.6	0.2	-0.8	-0.8	-1.5	-1.5	-0.8	-1.2	2.1	0.3	-0.4	1.3	-0.0
Number of full brothers	0.8	1.0	3.1	-1.7	0.7	0.4	1.1	0.2	0.3	-0.5	0.2	-1.8	-0.8	-1.4	-1.0
Worry too long after embarrassment	2.3	3.8	11.0	3.3	0.4	-1.7	-2.8	1.4	1.3	0.5	0.8	2.8	1.2	2.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.8	-1.5	-0.5	-0.3	0.4	-0.1	0.6	-0.4	1.0	-0.6	-1.0	-1.5	-1.7
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.3	-0.1	0.8	1.0	0.6	0.7	0.9	0.1	-0.6	0.4	-1.1	0.2
Number of children fathered	0.6	0.7	2.7	-0.7	-0.7	0.5	0.7	-1.0	-1.1	-0.0	-1.7	-0.8	0.1	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.2	0.4	1.5	1.2	1.0	1.8	1.6	1.3	-0.8	0.2	0.8	-0.3	0.1
Age at first live birth	1.2	2.1	6.2	2.3	0.8	-1.2	-1.7	1.0	1.3	0.2	1.1	1.6	1.2	2.5	0.8
Pulse wave peak to peak time	0.6	0.7	2.9	0.8	-0.2	0.1	0.3	0.4	0.4	0.8	-1.3	-0.2	1.7	0.7	1.2
Health satisfaction	2.1	2.7	6.8	0.4	1.1	1.6	1.8	2.6	1.9	2.2	-1.7	-0.9	2.0	-1.0	1.1
Shortness of breath walking on level ground	1.3	1.5	7.5	0.2	1.0	1.1	1.2	1.6	1.1	1.3	-2.7	-0.2	1.0	-0.3	0.1
Qualifications: College or University degree	0.5	1.7	5.7	1.9	0.3	-1.0	-1.1	-0.5	0.6	0.2	0.8	2.1	0.6	2.4	1.6
Eye problems/disorders: None of the above	0.5	0.5	2.7	-0.3	-0.9	0.6	-0.1	-0.7	-0.3	-1.0	-1.7	0.4	-0.8	0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.6	-1.4	-0.4	1.0	1.6	0.1	0.0	0.6	-0.6	-1.1	0.0	-1.9	0.0
Emphysema/chronic bronchitis	0.4	0.5	1.4	-0.6	-0.0	0.3	0.7	0.7	0.7	0.1	-0.9	-0.5	-0.3	-1.2	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.8	-0.6	-0.5	-0.1	-0.6	-0.4	-0.9	0.3	-0.8	-0.1	0.1	-0.5
Neck or shoulder pain in last month	1.1	1.5	3.5	-1.6	-0.8	1.8	1.5	-0.3	-1.4	-0.1	-0.2	-0.4	-1.6	-1.9	-1.1
Medication: Blood pressure	0.3	0.6	2.4	-0.8	-1.0	-0.5	0.5	-0.9	-0.5	-0.9	-0.5	-1.5	0.0	-0.9	-0.2
Angina (self-reported)	2.9	3.8	9.1	-2.4	-1.6	2.2	2.8	-0.6	-1.5	0.8	-1.4	-3.0	0.5	-2.5	-1.6
Migraine (self-reported)	1.0	1.3	4.2	0.2	1.5	2.0	1.0	1.4	0.7	1.7	-0.8	0.5	0.2	-0.9	-0.5
Medication: Ibuprofen	1.2	1.4	4.5	0.8	1.4	-1.6	-1.8	-0.4	0.7	-1.0	0.5	1.3	-0.3	2.1	0.5
Medication: Allopurinol	0.5	0.7	3.0	-0.9	-0.6	0.0	0.2	-0.1	0.0	-0.5	-0.9	-1.2	-0.1	-1.1	-1.7
Medication: Omeprazole	0.4	0.5	2.8	1.1	0.3	0.3	-0.5	-0.1	-0.8	0.7	-0.6	1.7	-0.4	-0.0	-0.1
Medication: Seretide 50 evohaler	1.4	1.6	5.2	2.3	0.1	0.1	-0.9	1.0	0.4	2.0	-0.7	1.9	1.6	1.2	0.1
Mean time to correctly identify matches	0.9	1.8	3.6	1.8	1.8	-1.2	-0.8	1.2	1.9	1.0	-1.2	1.5	1.3	1.1	0.4
Heart disease (mother)	0.4	0.5	2.4	-0.6	-1.6	0.8	0.7	-0.5	-0.7	-0.1	-0.1	-0.4	-0.3	-0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	4.1	-1.0	-0.4	-1.1	-0.5	-1.4	-0.8	-2.0	0.9	-0.5	-1.5	-0.6	-0.6
Whole body fat mass	0.6	2.7	6.5	1.3	2.1	0.2	0.5	2.1	2.5	1.9	-1.1	0.5	2.2	0.7	2.0
Leg fat mass (right)	0.6	2.3	6.9	1.2	1.3	0.6	0.6	1.7	1.8	2.1	-0.9	-0.0	2.6	0.7	2.2
Arm predicted mass (right)	0.7	3.8	14.8	1.2	-3.1	1.2	-0.2	-1.1	-2.1	0.7	0.3	-0.3	2.7	2.0	3.9
Pulse rate, automated reading	2.4	7.6	18.7	4.3	1.8	-1.4	-2.7	2.8	3.4	1.6	1.7	2.9	2.9	3.7	2.1
Alcohol intake frequency.	0.4	0.9	1.8	-0.7	0.9	0.8	1.0	1.4	1.2	0.8	0.9	-1.3	0.6	-1.0	-0.1
Comparative height size at age 10	1.2	6.8	18.3	4.0	-0.6	-0.5	-1.5	2.1	1.4	2.2	0.8	2.0	4.0	3.6	4.3
Number of full sisters	0.8	1.0	3.3	-1.0	-1.6	1.3	0.5	-0.9	-1.8	-0.8	0.2	-0.4	-1.1	-0.9	-0.2
Suffer from ‘nerves’	0.5	0.7	5.1	-0.3	-0.7	0.0	0.0	-1.0	-0.7	-0.5	-2.2	-0.1	-0.3	-0.3	-0.9
Overall health rating	0.5	1.2	3.2	-1.1	-0.1	1.7	1.6	0.8	0.5	0.4	-1.8	-1.0	0.0	-1.4	-0.5
Chest pain or discomfort	1.1	1.6	4.9	-1.5	-0.4	0.9	1.3	0.1	-0.6	-0.3	-1.7	-1.1	-0.8	-2.2	-1.9
Had major operations	1.7	2.0	5.0	1.3	1.1	-2.2	-1.9	-0.2	0.8	-1.0	2.0	2.0	-1.0	1.2	0.9
Age at last live birth	0.5	0.8	1.5	-1.2	0.1	0.8	1.1	0.9	0.9	-0.3	0.9	-1.1	-0.5	-0.9	-0.9
Family relationship satisfaction	0.1	0.1	0.3	0.6	-0.5	-0.5	-0.5	0.1	-0.3	0.2	0.3	0.3	0.4	0.1	0.5
Leg pain on walking	0.2	0.2	0.7	0.7	0.1	-0.1	-0.4	0.3	-0.6	0.9	0.2	0.6	0.6	0.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	-0.6	-0.3	-1.2	-1.3	-1.4	-1.1	-2.0	0.7	0.4	-1.5	0.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.1	0.1	-0.5	-0.1	0.3	0.6	0.6	1.0	-0.5	-0.8	1.5	0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	1.2	0.8	-1.4	-1.3	-0.5	-0.2	-0.1	0.5	1.2	-0.3	1.0	0.1
Medication: Aspirin	1.7	2.2	6.4	-1.6	0.0	2.2	2.3	1.0	0.8	1.0	0.2	-1.8	0.0	-2.5	-1.2
Supplements: Vitamin C	0.7	0.9	3.3	-0.2	-1.8	0.2	-0.2	-1.8	-1.7	0.0	-0.4	-0.5	0.3	-0.1	0.5
Knee pain experienced in last month	1.3	2.1	6.4	-0.0	-0.4	2.0	1.8	1.0	-0.1	2.5	-0.9	-1.2	2.1	-1.3	1.3
Hypertension (Self-reported)	1.0	2.8	6.4	-1.8	-2.0	1.1	1.6	-2.2	-2.5	-0.1	-0.1	-2.5	-0.1	-2.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.4	1.4	-0.2	1.1	0.3	1.1	1.1	1.9	-0.7	0.8	1.7	0.4	1.8
Illnesses of father: Heart disease	0.7	1.0	2.0	0.5	-0.3	-1.4	-1.2	-0.5	-1.2	-1.2	1.4	0.5	-1.1	-0.1	-1.0
Illnesses of siblings: Diabetes	1.1	1.3	3.3	-0.7	-0.4	1.5	1.5	0.5	-0.4	1.4	-1.0	-1.8	1.4	-1.2	-0.7
Smoking status: Previous	0.5	0.8	3.2	1.8	-0.1	-0.5	-1.2	0.6	-0.1	0.8	0.3	1.5	0.7	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.2	0.2	-1.8	0.9	0.3	-0.5	-1.2	-0.6	-1.2	0.1	-0.1	0.7	1.2
Whole body fat-free mass	0.6	3.6	13.3	1.2	-3.2	0.9	-0.4	-1.3	-2.2	0.6	0.5	-0.1	2.4	2.0	3.6
Leg fat-free mass (right)	0.3	1.6	5.6	0.5	-2.2	1.0	-0.0	-1.0	-1.6	0.4	0.3	-0.0	1.3	1.2	2.4
Arm fat percentage (left)	0.7	2.6	8.6	0.4	2.8	0.3	1.1	2.0	2.9	1.9	-1.4	-0.0	1.5	-0.4	0.8
Average weekly red wine intake	0.6	0.9	4.2	-0.3	-1.1	-0.8	-0.9	-2.0	-1.4	-1.1	0.5	0.1	-0.7	-0.1	-0.1
Handedness (chirality/laterality): Left-handed	2.1	2.5	6.0	-2.1	-2.5	1.7	1.6	-1.0	-1.7	0.3	-0.6	-2.0	-0.3	-2.2	-0.7
Mood swings	0.2	0.3	1.6	0.6	-1.3	0.3	-0.3	0.0	-0.3	0.3	-0.5	0.3	0.7	0.3	0.9
Loneliness, isolation	0.9	1.3	4.1	0.9	-0.3	-2.0	-1.5	0.0	0.8	-1.2	1.2	0.0	0.4	1.3	1.7
Long-standing illness, disability or infirmity	0.9	1.3	4.4	-1.7	0.1	1.3	1.4	0.7	0.2	0.1	0.2	-0.9	-1.1	-2.1	-1.5
Ever had bowel cancer screening	0.3	0.3	1.0	0.5	-0.1	-0.1	0.1	0.6	0.8	-0.2	-0.5	1.0	-0.4	0.2	0.8
Diabetes diagnosed by doctor	1.5	2.4	7.5	0.8	-0.2	1.7	1.4	2.0	1.6	2.0	-2.7	-0.4	2.2	-0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.8	0.9	2.0	-1.1	-0.1	1.5	2.2	1.2	1.4	0.6	0.9	0.2	-0.1
Friendships satisfaction	0.3	0.4	1.3	-0.8	-0.2	0.6	0.2	-0.0	-0.2	-1.1	-0.7	-0.4	-1.1	-0.7	-0.2
Qualifications: nursing, teaching	0.3	0.4	1.2	-0.8	-0.8	0.7	0.4	-0.9	-1.1	-0.4	0.0	-0.2	-0.8	-0.5	-0.4
Commuting to job workplace: Walk	0.5	0.6	3.2	0.4	1.8	0.6	0.6	0.7	0.9	0.7	-0.3	0.6	0.2	-0.1	0.9
Eye problems/disorders: Cataract	1.8	2.1	4.4	-1.2	1.9	0.7	2.1	1.8	1.5	1.4	1.5	-1.3	0.3	-1.8	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.1	-0.6	0.2	-1.2	-0.8	-0.8	-0.1	-2.2	0.8	0.7	-2.2	-0.1	-1.1
Medication for cholesterol	1.9	2.9	9.4	1.9	0.2	-3.1	-2.7	0.3	1.1	-1.4	0.1	2.2	-0.1	2.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.8	1.0	0.3	-0.3	-0.2	1.3	0.8	0.4	0.7	1.3	-0.0	0.4	0.4
Back pain experienced in last month	1.0	1.4	4.3	0.0	1.4	-2.1	-1.4	-0.3	0.8	-1.1	1.4	1.3	-1.6	0.1	-1.1
Mineral and other dietary supplements	1.3	1.7	4.7	-1.6	-0.6	2.2	1.8	-0.7	-0.7	0.1	-2.1	-1.3	-0.6	-1.5	-0.5
Breast cancer (self-reported)	2.5	3.0	10.2	0.4	2.2	0.2	0.9	2.8	3.2	1.9	0.1	-0.9	2.6	0.2	0.5
Asthma (self-reported)	0.2	0.4	1.2	0.7	-0.7	0.5	0.1	1.0	0.9	1.1	-0.6	0.3	0.7	-0.3	0.4
Osteoporosis (self-reported)	0.5	0.6	2.0	1.4	-0.1	-0.1	-0.9	-0.2	0.1	0.6	-0.5	1.1	0.9	1.0	0.9
Osteoarthritis (self-reported)	0.7	1.0	2.8	0.4	-0.6	1.7	0.9	0.7	-0.5	1.5	-1.5	-0.3	1.3	-0.4	0.1
Medication: Aspirin	1.5	1.9	5.0	-1.4	-0.1	2.2	2.2	0.9	0.7	1.1	0.1	-1.8	0.4	-2.2	-0.9
Medication: Gliclazide	0.3	0.4	0.8	-0.6	-0.9	0.4	0.3	-0.1	-0.4	0.2	-0.7	-0.8	0.5	-0.7	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.7	2.4	-1.6	0.4	0.5	1.0	0.1	0.9	-0.0	0.8	-1.1	-0.3	-0.7	-0.9
Smoking status: Current	1.1	1.7	4.5	-1.9	0.2	1.6	1.9	0.1	-0.3	-0.1	-1.4	-1.3	-1.1	-2.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	8.6	-0.5	-0.5	-1.8	-1.6	-2.9	-1.4	-2.5	0.7	1.1	-2.3	1.5	-0.8
Whole body water mass	0.6	3.6	13.1	1.1	-3.3	0.9	-0.4	-1.3	-2.1	0.5	0.5	-0.2	2.4	2.0	3.6
Leg predicted mass (right)	0.3	1.6	5.6	0.5	-2.3	1.0	-0.1	-1.0	-1.6	0.4	0.3	-0.0	1.4	1.2	2.4
Arm fat mass (left)	0.5	2.0	5.3	0.8	1.4	0.6	0.7	1.5	2.0	1.8	-0.9	-0.1	2.3	0.5	2.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.6	-0.0	-1.5	1.3	0.6	-0.2	-1.1	0.8	-1.6	-0.5	0.3	-1.2	0.7
Average weekly champagne plus white wine intake	0.3	0.4	1.4	-0.8	0.0	-0.1	0.8	-0.7	-0.1	0.2	-1.2	-0.5	-0.2	-1.0	-0.3
Miserableness	0.2	0.3	1.3	-0.4	0.1	0.4	0.7	0.5	0.3	0.6	-1.1	-0.1	-0.2	-1.0	-0.2
Guilty feelings	0.7	1.1	2.4	1.2	1.1	-0.4	-1.1	0.7	1.1	-0.0	-0.6	1.5	-0.1	1.5	1.4
Wears glasses or contact lenses	0.4	0.4	1.8	0.3	0.3	-1.3	-0.8	-0.1	0.7	-0.7	-1.1	0.3	-0.2	-0.0	-0.3
Ever taken oral contraceptive pill	0.7	0.8	2.5	-1.0	-0.3	1.4	0.9	0.2	0.4	-0.8	-1.6	-0.7	-0.7	-0.5	-1.3
Hearing aid user	1.9	2.2	6.5	0.3	2.6	-0.1	1.0	2.5	2.2	2.0	0.3	-0.3	1.0	-0.8	-1.3
Mother’s age at death	1.1	1.3	8.9	0.8	0.0	-3.0	-1.4	-1.3	-0.6	-0.6	0.6	0.8	0.1	0.8	0.5
Financial situation satisfaction	0.8	1.0	3.8	-1.1	0.7	0.9	1.3	1.0	0.1	0.6	0.0	-0.8	-0.5	-2.0	-1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.2	0.4	0.9	0.4	0.6	1.7	1.8	1.0	-0.1	-0.1	1.0	0.4	0.6
Commuting to job workplace: Public transport	2.0	2.4	5.3	2.0	-1.3	1.6	-0.5	-0.4	-1.3	1.4	-1.7	1.2	1.9	1.8	2.3
Eye problems/disorders: Glaucoma	0.2	0.2	1.2	-0.2	0.1	-0.3	0.0	-0.7	-1.1	0.0	0.8	-0.3	0.0	-0.1	0.5
Medication: Blood pressure	1.3	2.4	5.0	-1.7	-0.5	2.1	2.2	-1.1	-1.8	1.3	0.7	-2.1	0.3	-2.1	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.2	0.2	-0.5	-0.7	0.0	0.2	-1.0	-0.3	0.6	-0.6	-0.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	4.0	0.7	-0.2	-1.3	-1.2	-0.1	-0.1	-0.5	2.0	0.2	0.3	0.9	0.6
High cholesterol (Self-reported)	0.8	1.5	2.6	-1.5	-1.4	0.5	0.5	-1.5	-1.5	-1.4	-0.1	-0.9	-1.6	-1.3	-1.2
Medication: Bendroflumethiazide	0.9	1.3	5.4	-1.2	-0.7	-0.0	0.3	-2.3	-2.0	-0.9	0.0	-0.6	-1.4	-1.1	0.0
Medication: Paracetamol	1.1	1.7	7.2	1.5	1.8	0.3	0.3	1.2	0.6	1.2	-2.7	1.3	0.6	0.6	1.2
Medication: Lisinopril	0.8	1.0	4.0	0.3	-0.0	1.0	1.3	1.0	0.7	1.6	0.1	-0.2	1.0	-0.5	2.0
Medication: Atorvastatin	1.5	1.8	8.8	-0.6	-3.0	0.7	0.5	-1.1	-1.8	0.2	-1.3	-1.7	0.7	-0.9	-1.2
Illnesses of father: High blood pressure	0.7	0.9	3.3	-0.7	-1.2	0.8	0.4	-1.5	-1.8	-0.5	-1.0	-0.8	-0.1	-0.4	-0.2
Alcohol drinker status: Never	0.9	1.1	4.1	-1.3	-0.4	2.0	1.4	-0.3	-0.9	0.3	-0.9	-1.5	-0.1	-1.1	-0.5
Ever smoked	0.3	0.6	2.0	1.0	-0.2	-0.9	-1.3	-0.3	-1.0	-0.6	-0.0	1.4	-0.6	0.4	-0.3
Basal metabolic rate	0.5	3.0	13.2	1.3	-2.5	0.9	-0.3	-0.8	-1.4	0.8	0.4	0.0	2.5	2.0	3.6
Leg fat percentage (left)	0.7	2.5	7.0	1.1	2.5	-0.2	0.4	2.1	2.6	1.8	-0.9	0.0	2.2	0.4	1.4
Arm fat-free mass (left)	0.8	4.0	16.4	1.5	-3.0	0.9	-0.5	-1.0	-1.8	0.8	0.4	-0.3	3.0	2.4	4.0
Number of operations (self-reported)	1.0	1.4	3.2	1.1	1.3	0.5	0.3	1.2	1.8	1.4	-1.6	0.6	1.6	0.5	1.1
Average weekly beer plus cider intake	1.8	2.6	7.1	-2.2	-1.0	2.6	2.7	0.2	-0.4	-0.1	-1.3	-2.2	-0.7	-2.1	0.0
Irritability	0.3	0.6	2.2	-0.2	0.0	0.7	0.8	1.3	0.6	1.5	0.7	-0.3	0.6	-0.7	-0.2
Risk taking	0.2	0.3	1.0	-0.6	0.1	-0.6	-0.0	-1.0	-0.4	-0.8	-0.4	0.3	-0.9	-0.1	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.0	0.5	1.2	-1.4	-0.6	0.0	0.4	-0.3	0.3	0.3	-0.4	-0.3	-0.1
Fractured/broken bones in last 5 years	0.8	1.1	2.9	1.0	0.3	-1.4	-1.7	0.2	0.1	-0.5	1.2	1.6	-0.5	1.3	-0.8
Age started oral contraceptive pill	0.7	0.8	2.0	1.4	-0.3	-0.9	-1.3	0.2	-0.1	0.2	1.4	0.7	0.9	1.4	-0.0
Diastolic blood pressure, automated reading	0.3	0.8	2.1	1.1	1.1	-0.9	-0.7	-0.6	0.1	0.6	1.4	0.5	1.2	0.9	1.1
Ever depressed for a whole week	0.4	0.5	1.2	-0.7	0.9	0.9	0.7	0.9	1.1	0.2	-0.7	-0.1	-0.5	-0.5	-0.3
Unable to work because of sickness or disability	1.9	2.4	7.4	-2.6	-0.4	0.7	1.5	0.0	0.5	-1.2	-0.5	-1.3	-1.9	-2.2	-2.7
Commuting to job workplace: Cycle	1.1	1.3	3.8	-1.4	-0.7	0.3	0.4	-2.0	-1.6	-1.8	-0.4	-0.8	-1.5	-0.3	-0.9
Myopia	0.6	0.9	2.1	0.9	1.3	-1.1	-0.9	0.3	1.4	-0.6	-0.8	1.2	-0.4	1.4	-0.1
Vascular/heart problems diagnosed by doctor	1.1	3.1	6.8	2.1	1.9	-1.0	-1.6	2.4	2.6	0.1	-0.1	2.5	0.6	2.6	0.3
Cholesterol lowering medication	0.5	0.7	1.9	-0.6	-0.7	1.3	0.8	-0.6	-1.4	0.6	0.4	-1.0	0.2	-0.9	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.2	0.9	0.9	-0.2	-0.6	0.1	0.1	0.2	-0.5	1.8	-0.8	0.0	-0.0
Pain experienced in last month	0.3	0.5	1.8	-0.4	1.0	-0.3	0.3	0.9	1.3	-0.1	1.0	-0.7	0.0	-0.4	-0.6
Supplements: Calcium	0.3	0.3	1.3	-0.0	1.1	-0.2	-0.2	0.6	0.1	-0.6	1.1	0.4	-0.6	0.1	-0.2
Basal cell carcinoma (self-reported)	1.1	1.3	3.2	-0.8	-1.2	-0.9	-0.5	-1.6	-1.3	-1.5	1.8	-0.3	-1.2	0.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.1	-1.1	1.3	0.8	1.6	1.3	1.7	0.6	-0.5	-1.6	0.3	-1.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.9	-0.8	0.5	-0.3	0.2	0.0	0.2	-0.8	1.4	-0.1	-1.1	-0.5	-0.6
Heart disease (siblings)	1.5	1.8	6.2	-1.5	-0.3	2.3	2.5	0.9	0.0	0.8	-1.0	-1.3	-0.2	-1.8	-0.2
Alcohol drinker status: Previous	1.5	1.7	6.1	-0.5	1.3	0.6	1.2	2.5	2.4	1.0	0.8	-0.3	-0.1	-1.3	-1.5
Pack years of smoking	0.3	0.4	1.4	-0.3	0.0	0.6	0.8	1.2	0.4	0.9	0.2	-0.1	0.6	-0.7	-0.5
Impedance of whole body	0.9	4.8	17.9	1.0	4.2	-0.6	0.2	3.9	4.2	1.2	-0.4	1.7	-0.4	-0.3	-0.6
Leg fat mass (left)	0.5	2.0	6.3	1.2	1.2	0.5	0.4	1.4	1.6	1.9	-0.9	0.1	2.5	0.8	2.2
Arm predicted mass (left)	0.8	4.2	17.7	1.8	-2.9	0.7	-0.7	-0.9	-1.8	0.8	0.8	0.1	2.9	2.5	4.2