Best TWAS P=1.31e-08 · Best GWAS P=9.36e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SLC22A5 | 0.18 | 0.12 | enet | 8 | 0.12 | 2.5e-09 | -4.8 | 5.2 | 2.5e-07 | -0.01 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | UQCRQ | 0.21 | 0.01 | enet | 30 | 0.04 | 2.0e-02 | 4.1 | 5.6 | 1.8e-08 | 0.05 | 0.09 | 0.13 | TRUE |
| 3 | GTEx | Nerve Tibial | HSPA4 | 0.15 | 0.07 | lasso | 3 | 0.05 | 1.0e-04 | 5.6 | 5.5 | 3.2e-08 | 0.96 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PDLIM4 | 0.09 | 0.08 | lasso | 8 | 0.09 | 1.0e-07 | -4.9 | 5.3 | 1.4e-07 | -0.05 | 0.05 | 0.95 | FALSE |
| 5 | GTEx | Testis | P4HA2 | 0.14 | 0.13 | lasso | 5 | 0.11 | 1.4e-05 | -4.9 | -5.3 | 1.1e-07 | 0.06 | 0.04 | 0.95 | FALSE |
| 6 | GTEx | Testis | HSPA4 | 0.13 | 0.13 | lasso | 2 | 0.12 | 9.1e-06 | 5.7 | 5.7 | 1.3e-08 | 1.00 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HSPA4 | 0.03 | 0.02 | blup | 50 | 0.02 | 5.8e-05 | 5.0 | -5.2 | 1.9e-07 | -0.90 | 0.03 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC22A5 | 0.06 | 0.03 | lasso | 4 | 0.02 | 9.3e-04 | 5.0 | 5.4 | 8.0e-08 | 0.02 | 0.01 | 0.93 | FALSE |