Best TWAS P=1.57e-16 · Best GWAS P=2.76e-11 conditioned to 0.218
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | HSCB | 0.10 | 0.04 | enet | 8 | 0.05 | 2.2e-04 | -6.6 | 5.9 | 3.4e-09 | -0.93 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Spleen | RHBDD3 | 0.48 | 0.02 | lasso | 5 | 0.09 | 2.0e-03 | -3.0 | 6.1 | 1.4e-09 | -0.10 | 0.06 | 0.16 | TRUE |
| 3 | GTEx | Thyroid | HSCB | 0.08 | 0.03 | lasso | 5 | 0.05 | 8.9e-05 | -5.2 | 7.2 | 7.4e-13 | -0.75 | 0.01 | 0.96 | FALSE |
| 4 | METSIM | Adipose | CHEK2 | 0.05 | 0.04 | bslmm | 319 | 0.04 | 1.0e-06 | -6.4 | 7.7 | 2.1e-14 | -0.31 | 0.02 | 0.98 | FALSE |
| 5 | NTR | Blood | XBP1 | 0.03 | 0.03 | bslmm | 324 | 0.03 | 8.2e-09 | -5.7 | -6.5 | 8.5e-11 | 0.57 | 0.34 | 0.66 | FALSE |
| 6 | YFS | Blood | CHEK2 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.3e-06 | -5.4 | -5.4 | 7.5e-08 | 0.34 | 0.25 | 0.75 | FALSE |
| 7 | YFS | Blood | XBP1 | 0.13 | 0.14 | enet | 37 | 0.20 | 1.1e-64 | -4.4 | -5.6 | 1.8e-08 | 0.64 | 0.96 | 0.04 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TTC28 | 0.03 | 0.01 | blup | 194 | 0.01 | 3.7e-04 | -3.5 | 5.7 | 1.0e-08 | -0.23 | 0.57 | 0.34 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CHEK2 | 0.08 | 0.03 | blup | 46 | 0.04 | 2.5e-03 | -5.2 | 8.2 | 1.6e-16 | -0.61 | 0.03 | 0.53 | TRUE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HSCB | 0.03 | 0.01 | blup | 43 | 0.01 | 1.3e-02 | -6.1 | 5.9 | 2.8e-09 | -0.79 | 0.01 | 0.68 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HSCB | 0.12 | 0.02 | blup | 43 | 0.09 | 1.9e-04 | -5.2 | 6.2 | 6.2e-10 | -0.77 | 0.01 | 0.92 | FALSE |