TWAS hub - RHBDD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0220	5.7e-03	0.035	0.020	0.019	0.021	0.024	3.3e-05	1.6e-03	1.9e-03	0.0011	5.0e-04
2	GTEx	Pancreas	0.1840	0.0520	6.9e-05	0.122	NA	0.128	NA	0.134	8.4e-06	NA	4.6e-06	NA	2.9e-06
3	GTEx	Spleen	0.4830	0.1120	3.6e-04	0.020	NA	0.063	NA	0.095	9.7e-02	NA	1.0e-02	NA	2.0e-03
4	GTEx	Testis	0.3210	0.0890	3.8e-05	0.108	NA	0.097	NA	0.111	1.6e-05	NA	4.7e-05	NA	1.3e-05
5	METSIM	Adipose	0.0279	0.0129	3.6e-03	0.004	0.016	0.009	0.015	0.005	6.2e-02	1.7e-03	1.3e-02	0.0020	5.1e-02
6	TCGA	Breast Invasive Carcinoma	0.0700	0.0268	4.8e-08	0.022	0.034	0.041	NA	0.046	2.0e-05	1.2e-07	5.9e-09	NA	9.5e-10
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0336	0.0184	4.8e-03	0.003	0.021	0.017	NA	0.014	1.5e-01	1.6e-03	4.2e-03	NA	8.1e-03
8	TCGA	Brain Lower Grade Glioma	0.0258	0.0135	4.9e-03	0.009	0.008	0.000	NA	0.002	2.7e-02	3.4e-02	2.8e-01	NA	1.6e-01
9	TCGA	Lung Squamous Cell Carcinoma	0.0741	0.0372	1.1e-03	0.018	0.032	0.024	NA	0.030	3.4e-03	1.4e-04	9.0e-04	NA	2.0e-04
10	TCGA	Pheochromocytoma and Paraganglioma	0.1000	0.0520	8.7e-03	0.003	0.024	0.022	NA	0.008	2.3e-01	3.6e-02	4.6e-02	NA	1.5e-01
11	TCGA	Prostate Adenocarcinoma	0.0626	0.0326	6.0e-04	0.016	0.030	0.019	NA	0.022	7.5e-03	3.5e-04	3.6e-03	NA	2.2e-03
12	TCGA	Thyroid Carcinoma	0.0930	0.0450	4.6e-03	0.003	0.006	0.001	NA	0.015	1.5e-01	7.6e-02	2.2e-01	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Medication: Lisinopril	4.5	5.8	10.8	-2.5	-2.1	-0.7	-2.6	-2.7	-2.5	-2.9	-3.3	-2.4	-0.8	-3.2	-1.6
Heel T-Score	4.4	35.4	67.1	7.3	8.2	5.4	4.4	-4.0	3.8	7.0	7.3	5.5	5.9	7.5	-0.5
Pain all over the body in last month	4.2	4.5	7.8	2.0	1.9	0.7	2.2	2.1	1.9	2.7	2.8	2.2	1.8	2.3	1.9
Commuting to job workplace: Cycle	4.2	5.1	10.2	-2.9	-3.2	-0.5	-1.9	-1.0	-2.8	-2.6	-2.6	-2.4	-1.8	-2.3	-1.1
Breast Cancer	4.1	9.9	36.7	1.4	0.7	6.1	3.7	-1.0	3.6	2.4	3.4	1.3	-0.0	4.2	3.9
Happiness	3.7	4.5	9.8	-1.8	-1.2	-1.4	-2.1	-0.5	-2.1	-2.3	-2.6	-2.8	0.5	-2.9	-3.1
Had major operations	3.4	4.0	8.3	-2.6	-2.5	-1.1	-1.9	-2.9	-0.8	-2.5	-1.8	-1.8	-1.3	-2.3	-1.4
Number of operations (self-reported)	3.3	4.9	9.4	-2.8	-2.3	-1.7	-2.0	-3.1	-0.8	-2.4	-1.1	-3.1	-0.2	-2.2	-2.7
Time employed in main current job	2.9	3.3	8.3	1.3	1.4	2.2	1.5	2.9	2.5	2.1	2.4	1.1	0.6	1.6	0.7
Hair/balding pattern: Pattern 2	2.8	3.5	7.7	-1.3	-0.9	-0.6	-2.8	-2.4	-2.0	-1.6	-2.1	-0.9	0.4	-2.6	-2.6
Mouth/teeth dental problems: Loose teeth	2.8	3.3	6.8	-2.4	-2.6	1.3	-1.2	-1.9	-0.9	-2.3	-1.8	-2.1	-1.9	-1.7	-0.4
Wears glasses or contact lenses	2.8	3.2	8.1	-2.6	-1.7	-0.4	-2.1	0.1	-1.7	-1.7	-1.0	-2.5	-0.8	-1.7	-2.8
Hair/balding pattern: Pattern 4	2.7	6.4	15.1	1.5	1.2	2.9	2.6	3.9	2.2	2.6	3.1	1.4	-0.0	3.3	3.0
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	13.8	2.1	2.5	2.4	1.9	-2.2	1.4	2.9	3.2	2.6	2.0	3.7	0.4
Pack years of smoking	2.6	3.8	7.3	-1.9	-1.9	-1.7	-2.0	-1.1	-2.7	-2.3	-2.5	-1.9	0.1	-2.2	-1.5
Commuting to job workplace: Car/motor vehicle	2.5	2.8	10.4	1.8	2.7	1.1	-0.2	0.3	-0.8	1.8	0.9	2.0	3.2	0.4	-1.7
Commuting to job workplace: Public transport	2.5	3.0	6.9	-1.9	-2.2	-0.5	-0.7	-1.3	-0.4	-2.3	-1.9	-2.5	-2.6	-1.5	0.1
Heart disease (siblings)	2.5	3.1	9.0	1.6	1.9	0.6	1.5	3.0	0.9	2.2	2.1	1.3	1.5	2.1	0.5
Medication: Simvastatin	2.3	3.3	8.5	-1.2	-0.5	-1.4	-2.9	-2.1	-1.7	-1.3	-2.5	-0.9	0.9	-2.6	-2.3
Medication for pain relief, constipation, heartburn	2.3	3.9	10.2	-1.4	-2.1	-0.5	-1.5	-2.7	-1.0	-2.9	-2.0	-1.9	-3.2	-1.9	-0.3
Medication: Allopurinol	2.3	3.0	5.4	1.5	1.6	0.9	2.1	2.0	1.2	2.2	2.2	1.3	1.8	2.3	0.8
Ever had bowel cancer screening	2.3	2.7	6.5	-2.6	-2.2	0.4	-1.5	-1.6	-1.4	-1.8	-1.3	-2.1	-0.8	-1.4	-1.6
Pack years adult smoking proportion	2.2	3.4	6.8	-1.9	-1.8	-1.9	-1.8	-1.0	-2.6	-2.2	-2.4	-1.7	0.2	-2.1	-1.1
Family relationship satisfaction	2.2	2.7	4.7	-2.1	-1.7	-0.2	-1.8	-0.5	-1.7	-1.8	-1.6	-2.2	-0.3	-1.9	-2.0
Sensitivity / hurt feelings	2.1	3.7	9.5	-2.9	-2.4	-0.0	-0.9	-0.2	-2.3	-2.2	-1.7	-3.1	-1.0	-1.6	-1.6
Schizophrenia vs Biploar Disorder	2.0	2.7	9.0	2.1	2.0	-1.4	0.9	1.1	0.8	2.0	1.2	3.0	1.2	1.6	0.8
Lung FEV1/FVC ratio	2.0	9.9	25.0	3.5	4.0	1.3	1.0	-5.0	2.3	3.4	2.6	4.6	3.9	1.9	0.4
Alcohol drinker status: Previous	2.0	2.3	5.6	2.3	2.4	2.0	0.4	0.8	0.9	1.4	1.1	1.8	1.5	1.4	0.0
Medication: Metformin	1.9	2.6	8.5	1.3	1.1	-2.3	1.3	2.9	0.9	1.9	1.7	1.4	0.3	0.7	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	9.1	2.0	2.5	0.8	1.1	-2.1	0.9	2.7	2.6	2.7	2.3	3.0	-0.3
Prospective memory result	1.9	2.4	8.7	0.4	-0.1	1.4	1.1	0.9	2.0	1.2	0.7	2.6	0.8	1.4	3.0
Birth weight of first child	1.9	3.4	6.0	-2.1	-1.8	-0.8	-2.3	0.4	-2.1	-2.0	-1.6	-2.2	-1.4	-1.8	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	6.9	-1.0	-0.1	-0.2	-1.9	-1.4	-1.9	-0.8	-1.7	-1.3	1.2	-1.9	-2.6
Supplements: Vitamin C	1.9	2.3	7.4	1.5	0.7	2.7	1.2	-0.2	2.4	0.5	1.2	0.8	-1.5	1.6	1.6
Glaucoma (self-reported)	1.8	2.1	5.6	0.4	1.5	-1.2	1.1	2.2	0.7	1.8	1.8	0.4	2.4	1.0	-1.1
Exposure to tobacco smoke outside home	1.8	2.3	5.2	1.7	1.6	-0.8	2.3	1.5	1.6	1.9	1.9	0.9	0.8	1.5	1.2
Primary Biliary Cirrhosis	1.7	2.5	11.0	0.3	1.4	-0.5	-2.0	0.0	-1.1	0.1	-0.9	0.2	3.3	-1.7	-2.8
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.2	-1.3	-1.4	-1.4	-1.3	0.5	-2.1	-1.7	-1.7	-1.7	-0.9	-1.5	-0.7
Hearing difficulty/problems: Yes	1.7	2.5	14.0	1.4	1.5	-0.7	0.1	3.7	0.9	1.5	0.7	2.3	1.6	0.6	0.1
Severe depression (siblings)	1.7	1.9	5.0	0.8	1.0	1.3	1.2	2.0	1.3	1.4	2.2	1.0	1.5	1.7	-0.2
Financial difficulties in last 2 years	1.7	2.4	5.5	1.1	1.1	1.2	2.3	1.4	1.4	2.0	2.1	1.0	1.6	1.5	0.9
Commuting to job workplace: Walk	1.7	1.8	6.7	-2.0	-2.6	-0.0	0.2	0.9	1.0	-0.9	-0.5	-0.8	-2.3	-0.2	1.6
Bipolar Disorder (2018)	1.6	2.5	6.2	-1.7	-1.9	0.5	-1.1	-0.1	-0.4	-2.2	-1.6	-2.5	-2.2	-1.8	-0.7
Mean Putamen Volume	1.6	1.8	4.5	-1.1	-1.7	-2.1	-0.7	-0.3	-1.3	-1.6	-1.2	-1.5	-1.8	-1.1	0.4
Stomach or abdominal pain in last month	1.6	2.0	3.3	-1.8	-1.5	-1.2	-1.3	0.4	-1.7	-1.4	-1.3	-1.7	-0.2	-1.5	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	6.3	-2.0	-1.4	-0.7	-1.2	1.3	-2.5	-1.1	-1.3	-2.0	0.3	-1.6	-2.3
Respiratory disease	1.5	3.2	7.3	-2.4	-2.7	-0.8	-1.0	-0.9	-1.4	-2.3	-1.8	-2.7	-1.5	-1.8	-0.4
Pulse rate	1.5	2.6	5.5	-2.3	-2.2	-1.2	-1.5	-0.2	-1.2	-2.0	-1.7	-2.0	-1.5	-1.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.8	0.9	0.9	-0.2	1.9	1.5	1.0	1.9	1.8	1.1	1.7	1.6	1.0
Medication: Paracetamol	1.5	2.4	5.6	0.9	1.2	0.8	1.4	2.4	1.0	2.1	2.1	1.3	1.4	2.2	0.3
Medication: Ibuprofen	1.5	1.8	4.4	0.7	0.7	-0.1	1.9	1.6	0.9	1.9	1.6	1.0	2.1	1.4	0.7
Number of self-reported non-cancer illnesses	1.5	2.6	5.3	-1.7	-0.9	-0.3	-1.7	0.5	-1.4	-1.5	-1.9	-1.9	1.7	-2.3	-2.1
Ever had hysterectomy (womb removed)	1.4	1.6	3.4	1.8	1.5	-0.2	0.8	0.7	1.8	1.3	1.0	1.8	1.6	0.6	0.6
Medication: Co-codamol	1.4	1.6	3.3	1.4	1.7	-1.3	0.2	1.4	1.3	1.4	0.9	1.8	1.7	0.7	0.1
Asthma	1.4	2.8	8.0	-2.2	-2.4	-0.4	-0.7	-0.8	-1.5	-2.0	-1.9	-2.8	-0.4	-1.9	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	11.1	3.1	3.1	-1.7	1.0	0.6	0.8	2.4	2.0	3.3	1.9	1.8	0.2
Migraine (self-reported)	1.4	1.7	3.8	1.1	1.6	0.2	0.8	1.6	1.2	1.9	1.4	1.5	1.7	1.2	0.1
Pulse rate, automated reading	1.4	4.6	8.8	-3.0	-2.9	0.1	-1.8	-2.0	-1.2	-2.7	-2.4	-2.5	-1.7	-2.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.4	-0.4	-0.2	-0.4	-2.3	-2.3	-0.2	-1.2	-1.1	-0.2	-0.2	-1.5	-1.4
Back pain experienced in last month	1.4	2.1	10.1	-0.9	-0.1	0.8	-1.7	-1.2	-1.8	-1.2	-0.8	-1.7	0.5	-1.1	-3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	7.3	2.7	2.3	-0.2	1.7	0.5	1.0	1.7	1.6	2.6	0.1	1.9	1.7
Neuroticism	1.3	3.2	9.2	-1.9	-1.1	-1.2	-1.8	-2.2	-1.6	-1.1	-1.2	-1.3	1.9	-1.9	-3.0
Multivitamins +/- minerals	1.3	1.6	4.5	1.9	2.1	-0.6	0.0	0.6	1.1	1.5	0.7	2.1	1.3	0.9	-0.0
Number of incorrect matches in round	1.3	2.1	6.2	-0.2	0.1	2.4	1.6	2.5	2.2	0.8	1.7	-0.8	0.9	0.2	0.6
Nervous feelings	1.3	2.4	7.4	-2.4	-2.7	-1.2	-0.6	-0.3	-0.5	-2.0	-1.8	-2.0	-0.8	-1.6	-0.3
Had other major operations	1.3	1.5	3.8	1.5	2.0	0.4	0.9	1.5	0.8	1.4	1.7	0.3	1.5	0.8	-1.0
Mouth/teeth dental problems: Dentures	1.3	2.1	5.2	2.3	1.8	0.9	1.9	-0.2	0.8	1.6	0.8	1.8	0.8	1.2	1.8
Ever highly irritable/argumentative for 2 days	1.3	1.5	5.4	-0.8	-0.2	-0.6	-1.2	-0.6	-1.5	-0.9	-1.5	-0.3	2.3	-1.2	-1.8
Age at first live birth	1.3	2.3	7.3	-1.9	-2.1	0.3	-1.0	-1.0	-0.8	-1.7	-1.7	-1.6	-2.7	-1.1	-0.2
Worry (Nagel 2018)	1.2	2.5	5.2	-2.3	-2.1	-1.6	-1.4	-1.5	-1.0	-1.5	-1.4	-1.5	0.2	-1.7	-1.7
Body Mass Index (BMI) (2010)	1.2	1.7	3.0	0.9	1.1	1.4	1.6	0.8	1.4	1.6	1.7	1.2	1.4	1.1	0.6
HDL Cholesterol	1.2	2.0	6.5	1.2	0.5	0.8	1.1	2.6	1.6	1.1	1.2	1.5	-0.4	1.7	2.0
Supplements: Zinc	1.2	1.3	3.3	1.7	1.2	1.8	1.0	0.4	0.9	0.8	1.2	0.8	-0.1	1.4	0.9
Hand grip strength (right)	1.2	3.2	11.3	-1.3	-1.2	-3.4	-1.7	-0.7	-2.4	-1.6	-2.3	-1.0	-1.1	-1.8	-0.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.5	-0.1	0.7	-1.0	0.4	1.5	0.1	1.5	1.8	-0.2	1.9	0.4	-1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.5	-0.7	-0.3	-1.4	-2.1	-0.9	-0.9	-0.7	-1.5	0.4	1.4	-1.6	-1.1
Fluid intelligence score	1.2	2.4	7.8	-1.3	-1.4	-0.4	-1.4	-2.8	-1.6	-1.7	-0.9	-1.3	-2.4	-0.4	-1.3
Tense / ‘highly strung’	1.2	1.9	5.2	-2.2	-2.3	-1.3	-1.1	-0.7	-0.8	-1.5	-0.4	-1.8	-0.5	-0.9	-1.5
Chest pain or discomfort	1.2	1.7	6.9	-1.1	-0.5	-2.2	-0.6	0.8	-0.8	-0.7	0.1	-1.8	0.5	-1.1	-2.6
Asthma (self-reported)	1.2	2.4	7.0	-2.1	-2.3	-0.2	-0.6	-0.7	-1.4	-1.9	-1.7	-2.6	-0.4	-1.7	-0.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.3	0.3	1.3	-0.8	1.3	1.6	0.4	1.4	1.7	-0.5	1.8	0.7	-1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	7.7	0.8	0.7	-2.3	1.3	2.8	0.3	1.4	1.2	1.2	-0.2	0.9	2.0
Chronotype (morning person)	1.1	2.6	6.8	-2.6	-2.6	-0.1	-1.0	-0.5	-0.5	-1.9	-1.8	-2.0	-1.0	-2.0	-0.0
Medication: Cholesterol lowering	1.1	1.8	9.0	-0.3	0.4	-0.6	-2.5	-0.3	-0.8	-0.6	-0.8	-0.2	1.3	-1.4	-3.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	5.6	-1.3	-1.6	-1.0	-0.4	-0.0	-0.7	-1.2	-1.3	-1.3	-2.4	-0.6	-0.4
Emphysema/chronic bronchitis	1.1	1.2	7.8	0.2	1.1	0.5	-0.3	1.3	0.0	0.9	0.6	0.4	2.8	-0.1	-1.5
Medication: Blood pressure	1.1	2.0	6.4	-1.2	-0.5	-0.6	-2.3	0.4	-2.0	-1.2	-1.3	-0.8	0.2	-1.6	-2.5
Suffer from ‘nerves’	1.1	1.7	3.2	-1.7	-1.8	-1.8	-1.5	-0.2	-1.4	-1.4	-1.6	-0.6	-0.8	-0.8	-0.8
Eye problems/disorders: Cataract	1.1	1.2	3.0	-1.4	-1.7	-1.0	-0.4	-0.2	-0.5	-1.4	-0.9	-1.6	-1.2	-1.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.8	1.5	1.2	-0.8	0.8	0.2	1.4	1.1	0.9	1.2	2.0	0.5	1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	5.5	-2.0	-2.2	-0.1	-0.9	0.8	-0.3	-2.3	-1.8	-2.3	-1.8	-1.4	-0.6
Ulcerative Colitis (UC)	1.0	1.9	6.5	1.5	1.3	-0.7	2.0	2.6	0.9	1.2	1.0	1.0	-0.3	1.1	1.7
Neuroticism (2016)	1.0	1.4	5.7	-1.9	-1.1	-0.7	-1.5	0.5	-1.2	-0.5	-0.3	-0.6	0.9	-0.5	-2.4
Allergy or Eczema	1.0	2.6	6.7	1.0	0.6	-0.5	2.4	2.6	2.4	1.3	2.6	0.5	-0.1	1.6	0.3
Average weekly fortified wine intake	1.0	1.1	4.2	-0.1	-0.4	2.0	1.6	1.0	0.9	0.3	0.9	-0.1	-1.2	0.9	1.4
Chronic bronchitis/emphysema (father)	1.0	1.1	4.3	0.2	0.7	1.9	0.5	0.5	1.2	1.2	1.1	0.2	2.1	0.6	-0.6
Heart attack	1.0	1.2	3.7	-1.1	-0.7	-1.2	-1.6	-0.4	-1.3	-0.5	-0.8	-0.3	0.9	-1.2	-1.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	7.9	2.8	2.8	-1.9	0.7	0.3	0.8	2.1	1.9	2.8	1.7	1.4	-0.3
Impedance of arm (left)	1.0	4.8	12.8	2.1	1.2	2.1	2.4	1.4	1.9	1.9	2.5	2.1	0.2	3.6	2.9
Medication: Aspirin	1.0	1.4	3.1	1.2	1.8	0.6	0.7	0.8	0.9	1.7	1.1	1.4	1.7	0.7	0.2
Medication for cholesterol	1.0	1.6	5.2	1.0	0.5	1.1	0.9	1.3	1.1	0.9	1.8	1.2	-1.2	2.3	0.8
Illnesses of father: None of the above (group 1)	1.0	1.3	6.6	0.4	-0.6	-2.2	0.5	0.1	-0.9	-0.9	-0.5	-0.7	-2.6	-0.2	0.7
Ever depressed for a whole week	1.0	1.2	3.8	-0.8	-0.1	-1.4	0.8	1.9	-1.9	-0.1	0.1	-1.9	0.1	0.1	-0.6
Unable to work because of sickness or disability	1.0	1.3	3.3	-0.7	-0.6	1.0	-1.2	0.8	-1.8	-1.0	-1.3	-0.8	-0.5	-1.6	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	6.1	0.4	0.4	2.5	1.4	1.5	0.9	0.7	1.4	0.1	-0.8	0.8	0.3
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.8	-1.3	-1.1	-2.0	-2.2	-2.4	-1.5	-1.9	-1.8	-0.9	-1.1	-1.5	-1.6
Crohns Disease (2012)	0.9	1.4	10.3	0.8	1.0	-3.2	0.1	0.9	-1.2	0.5	0.0	-0.1	0.6	-0.5	-1.2
Blood Platelet Count	0.9	10.5	27.4	-1.7	-3.3	2.1	5.2	1.8	3.1	-0.4	3.2	-3.0	-5.2	3.2	3.3
Diabetes (father)	0.9	1.1	3.4	-1.8	-1.7	1.2	-0.5	-1.0	-0.6	-0.8	-0.5	-1.3	-0.6	-0.6	0.2
Trunk fat percentage	0.9	3.7	7.0	1.8	1.9	2.2	1.1	1.9	1.4	2.3	2.3	2.6	1.2	2.0	1.6
Maternal smoking around birth	0.9	1.3	3.3	1.5	1.7	-0.6	0.4	1.6	0.6	1.4	0.5	0.9	1.8	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	0.9	1.8	5.3	0.9	0.5	-0.2	2.1	2.3	1.9	1.0	2.1	0.1	-0.1	1.4	0.4
Peak expiratory flow (PEF)	0.9	2.1	9.9	1.1	1.6	-3.1	-1.5	-1.0	-0.1	0.4	0.4	0.9	1.5	-0.9	-2.2
Gout (self-reported)	0.9	1.2	3.5	0.8	0.7	0.6	1.3	1.2	0.3	1.3	1.3	1.0	0.9	1.9	1.1
Worry too long after embarrassment	0.9	1.5	4.4	-1.7	-1.5	-0.5	-1.2	-0.2	-0.2	-1.2	-1.1	-1.8	0.1	-2.1	-1.1
Number of children fathered	0.9	1.0	2.8	-0.6	-0.5	0.6	-0.1	-0.9	-1.7	-1.3	-1.0	-1.4	-1.0	-0.8	-0.9
Heart disease (mother)	0.9	1.1	4.5	0.7	1.1	0.7	-0.3	0.8	0.5	1.4	1.0	1.1	2.1	1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.3	1.2	1.5	-0.5	1.3	1.0	0.8	1.5	0.9	0.7	1.2	0.9	0.3
Medication: Aspirin	0.9	1.2	3.2	1.2	1.7	0.3	0.4	0.7	0.5	1.6	0.9	1.4	1.8	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.0	-1.1	-0.8	-1.5	-1.5	-0.1	-1.3	-0.6	-0.8	-0.3	0.6	-1.0	-1.7
Depressed Affect (Nagel 2018)	0.8	1.6	10.1	1.0	1.5	-0.0	0.6	-0.5	-0.5	1.3	0.9	1.1	3.2	0.6	-0.9
Waist Hip Ratio (WHR)	0.8	3.4	8.8	-2.8	-3.0	-1.7	-0.1	-0.4	-1.6	-2.2	-2.0	-2.2	-1.3	-2.0	-0.2
Hand grip strength (left)	0.8	2.0	11.0	-0.1	0.1	-3.3	-1.3	-0.6	-2.2	-0.5	-1.6	0.2	0.4	-1.1	-1.4
Relative age of first facial hair	0.8	1.6	8.5	0.2	0.6	-2.9	-0.6	1.4	0.7	0.0	-0.1	-0.2	2.1	-0.4	-1.7
Systolic blood pressure, automated reading	0.8	2.4	8.0	-2.0	-1.5	0.2	-1.8	-0.2	-0.5	-1.7	-2.2	-1.3	0.5	-2.8	-1.4
Fed-up feelings	0.8	1.5	9.4	1.2	1.8	1.0	0.3	-0.9	0.0	1.0	0.4	0.7	3.1	0.2	-0.9
Neuroticism score	0.8	1.8	5.2	-1.7	-1.1	-0.3	-0.9	-1.5	-1.2	-1.0	-0.7	-1.4	1.5	-1.2	-2.3
Impedance of arm (right)	0.8	3.9	10.0	2.4	1.7	1.4	1.9	1.3	1.7	1.9	2.3	2.0	0.5	3.2	2.1
Alcohol intake versus 10 years previously	0.8	1.2	3.6	-0.9	-1.1	-0.2	-0.5	-1.1	-1.5	-1.4	-1.4	-0.7	-1.9	-0.4	0.9
Number of live births	0.8	1.2	3.4	0.3	0.8	1.9	1.0	-0.2	1.4	1.1	1.9	-0.1	0.8	1.2	-0.4
Breastfed as a baby	0.8	1.0	4.1	-2.0	-1.6	0.4	-0.5	1.1	-0.5	-0.9	-0.7	-1.4	-0.3	-0.8	-0.3
Pulse wave reflection index	0.8	0.9	2.1	1.4	1.3	1.2	1.2	0.1	0.6	1.0	0.7	0.8	0.6	1.0	0.7
Blood clot in the leg (DVT)	0.8	1.0	5.5	0.3	0.3	2.4	1.2	1.3	0.9	0.5	1.1	0.0	-0.6	0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.4	0.9	0.3	0.3	1.9	0.1	1.3	1.0	1.2	0.6	-0.2	1.3	2.1
Mean time to correctly identify matches	0.8	1.5	5.5	0.0	-0.4	2.3	1.8	0.2	1.5	0.5	0.9	0.8	-0.0	1.5	1.6
Breast cancer (self-reported)	0.8	1.0	2.2	1.2	1.5	-1.4	-0.1	1.1	0.1	0.8	0.6	1.3	1.2	0.7	-0.7
Guilty feelings	0.8	1.3	3.3	-1.8	-1.6	-0.7	-1.4	-0.1	-0.8	-1.0	-1.0	-0.8	0.3	-1.1	-1.6
Medication: Paracetamol	0.8	1.3	2.8	0.5	0.9	1.6	0.5	1.7	0.8	1.2	1.5	0.5	1.3	1.3	-0.5
Illnesses of father: High blood pressure	0.8	0.9	5.0	-1.1	-0.3	-0.7	-1.5	-0.5	0.5	0.2	-0.1	0.6	2.2	-0.5	-1.0
Impedance of whole body	0.8	4.2	9.6	2.5	1.7	1.4	2.2	1.5	2.0	1.8	2.3	2.0	0.3	3.1	2.4
Neuroticism (Nagel 2018)	0.7	1.6	5.0	-1.6	-1.0	-1.1	-1.2	-1.1	-1.3	-0.5	-0.6	-0.8	1.6	-1.1	-2.2
Alzheimer’s Disease (in mother)	0.7	0.9	2.6	0.5	0.8	-1.6	-0.7	0.2	0.8	0.7	0.9	1.0	1.1	0.3	-1.6
Ovarian Cancer	0.7	0.9	5.4	-0.6	-0.7	-2.3	-0.0	0.9	0.6	-0.5	-0.3	-0.7	-1.2	-0.8	-0.5
Bipolar Disorder (2011)	0.7	0.7	2.4	-1.4	-1.2	-1.6	-1.5	-0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.7	0.9	2.6	-0.3	0.2	-0.5	-1.4	-1.0	-0.2	-0.5	-0.9	-0.9	0.8	-1.4	-1.6
Triglycerides	0.7	1.1	2.7	-1.2	-0.7	-1.4	-0.8	-1.5	-1.6	-0.6	-0.8	-0.6	0.6	-0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.4	0.6	0.7	1.0	-0.0	1.4	1.5	0.7	0.6	0.7	1.4	-0.0	0.7
Forced vital capacity (FVC)	0.7	2.7	5.3	2.3	2.2	-1.8	0.8	2.3	0.4	1.8	1.7	1.9	1.0	1.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	0.3	0.5	-1.2	1.1	1.0	-0.2	1.0	1.0	0.1	1.6	1.3	0.3
Worrier / anxious feelings	0.7	1.3	5.4	-1.2	-0.5	-0.1	-0.3	-0.9	-0.3	-0.6	-0.1	-1.6	2.0	-1.0	-2.3
Falls in the last year	0.7	1.0	5.0	-0.5	0.3	-0.7	-1.0	0.5	-1.1	-0.0	-0.0	-0.3	1.7	-0.5	-2.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.3	-2.0	-1.9	0.3	-1.4	-2.3	-0.7	-1.0	-0.8	-0.9	-0.5	-0.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	1.2	1.0	-0.6	1.4	0.9	0.8	1.1	1.2	0.6	0.6	0.8	0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.4	0.5	0.4	0.5	0.7	0.4	1.2	1.2	1.4	1.5	1.2	1.6	0.5
Body fat percentage	0.7	2.8	5.2	1.6	1.8	1.9	0.9	1.7	1.2	2.1	1.9	2.3	1.3	1.4	1.3
Wheeze or whistling in the chest in last year	0.7	1.3	5.0	-1.2	-0.9	-1.2	0.5	2.2	-1.5	-0.2	0.1	-1.3	0.2	-0.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.8	-1.5	-1.2	0.8	-1.7	0.3	-0.8	-0.8	-0.6	-0.2	-0.5	-0.1	-0.8
Pulse wave peak to peak time	0.7	0.8	2.5	-1.0	-1.3	-1.2	-0.8	-0.8	-0.6	-1.0	-0.8	-0.2	-1.6	-0.6	-0.2
Medication: Omeprazole	0.7	0.9	5.2	-0.4	0.3	0.5	-1.5	-0.1	-0.3	0.5	-0.5	0.8	2.3	-0.6	-1.0
Overall health rating	0.7	1.6	9.1	0.0	0.8	2.1	-0.1	1.7	-0.2	0.8	0.2	0.1	3.0	-0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.9	-0.7	-0.4	-0.7	-1.0	-1.1	-0.8	-0.7	-1.4	-0.4	1.1	-1.3	-0.7
Mood swings	0.7	1.2	5.0	-0.6	-0.3	-0.4	-0.9	-1.2	-2.2	-0.7	-0.9	-0.5	1.4	-0.9	-1.6
Miserableness	0.7	1.2	5.3	0.9	1.4	0.5	0.7	0.7	-0.1	1.1	1.2	1.0	2.3	1.2	-0.4
Ever taken oral contraceptive pill	0.7	0.7	2.3	-1.1	-1.0	-0.4	-0.1	-0.3	-1.5	-0.7	-0.1	-1.2	-1.3	0.1	-0.8
Ever smoked	0.7	1.3	2.6	-0.7	-0.4	-1.0	-1.2	0.9	-1.4	-1.2	-1.1	-1.5	0.4	-1.4	-1.6
Myopia	0.7	0.9	2.6	-1.4	-1.1	-1.2	-1.6	0.7	-0.5	-0.6	-1.1	-0.1	0.5	-0.8	-0.9
Ulcerative Colitis	0.6	0.9	3.9	0.9	0.7	-1.5	0.9	2.0	1.1	0.5	0.4	0.2	-0.1	-0.1	0.5
Number of treatments/medications taken	0.6	1.0	7.4	-0.1	0.8	0.5	-0.2	1.1	0.3	0.7	-0.2	0.6	2.7	-0.1	-1.2
Angina	0.6	0.7	3.5	0.4	0.5	-1.9	-0.3	1.2	-0.0	0.5	0.2	0.4	1.5	0.1	-0.8
Vitamin and mineral supplements	0.6	0.8	3.0	-1.7	-1.4	-0.5	0.1	-0.6	-1.3	-0.5	0.0	-1.4	0.1	-0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.1	-0.6	-1.1	0.4	-0.9	-0.4	-0.4	-1.4	-1.4	-0.1	-0.4	-1.0	0.2
Medication: Atenolol	0.6	0.7	2.6	1.1	1.2	-0.8	0.2	1.2	-0.6	0.6	0.0	0.8	1.6	0.0	-0.0
Diabetes (self-reported)	0.6	1.0	4.5	0.3	0.7	-1.0	0.6	2.1	0.2	1.4	1.1	0.7	0.8	0.3	0.9
Medication: Ramipril	0.6	0.8	2.3	0.5	0.9	-1.2	-1.2	0.9	-0.8	0.4	-0.2	1.1	0.7	-0.1	-1.5
Noisy workplace	0.6	0.8	3.4	0.5	0.0	1.6	1.0	1.9	-0.5	0.2	-0.5	0.3	0.8	0.3	1.1
Lung cancer (father)	0.6	0.7	2.9	-0.6	-0.9	-0.2	-0.7	-0.2	-0.9	-1.0	-1.7	-0.5	-0.5	-1.3	-0.3
Medication: Amlodipine	0.6	0.8	2.5	-1.1	-0.7	0.1	-0.7	0.1	-1.6	-0.8	-1.0	-0.9	-0.1	-1.3	-0.9
Forced vital capacity (FVC), Best measure	0.6	2.1	4.8	2.2	1.8	-1.8	0.8	2.2	-0.1	1.3	1.2	1.9	0.4	1.4	0.4
Angina (self-reported)	0.6	0.8	2.8	0.5	0.7	-1.7	-0.2	1.3	0.2	0.7	0.3	0.7	1.5	0.1	-0.8
Long-standing illness, disability or infirmity	0.6	1.0	2.6	0.6	1.3	1.4	-0.4	1.6	-0.4	0.6	-0.2	0.4	1.4	-0.3	-1.3
Average weekly champagne plus white wine intake	0.6	0.8	2.6	0.4	0.3	-1.5	0.3	1.1	1.2	0.7	1.6	0.4	0.1	1.0	0.4
Medication: Blood pressure	0.6	1.1	5.9	-0.7	-0.3	-0.8	-0.8	0.1	-0.0	-0.7	-1.6	-0.9	1.1	-2.4	-0.8
Irritability	0.6	1.0	5.0	-0.7	-0.0	-0.3	-0.4	-2.2	-1.4	0.0	-0.3	-0.1	1.5	-0.2	-1.4
Fractured/broken bones in last 5 years	0.6	0.8	3.3	0.1	-0.2	0.1	1.4	1.8	0.2	0.5	-0.2	0.7	0.8	-0.2	1.5
Age started oral contraceptive pill	0.6	0.7	1.5	-0.7	-1.0	0.6	-0.6	0.1	0.6	-1.2	-1.1	-0.9	-1.0	-1.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	4.8	-0.1	0.6	0.5	-0.8	0.1	-0.3	0.9	-0.2	0.9	2.2	-0.2	-0.7
Basal cell carcinoma (self-reported)	0.6	0.7	3.0	-0.4	-0.6	0.4	1.1	1.4	0.5	0.1	0.3	-0.3	-1.1	0.7	1.7
Depression (Nagel 2018)	0.5	0.7	2.9	-0.4	-0.1	-1.1	-0.3	-0.3	-0.9	-0.4	-0.8	-0.4	1.7	-1.2	-1.2
Irritable Bowel Disease (IBD)	0.5	1.3	6.5	1.2	1.1	-1.5	1.4	2.5	0.2	0.9	0.6	0.4	0.0	0.4	0.4
Prostate Cancer	0.5	0.7	4.2	-0.0	0.1	-2.0	-0.5	1.0	-0.9	-0.5	-0.5	0.0	0.6	-0.6	-1.2
Age at First Birth	0.5	0.7	2.5	-0.9	-1.3	0.9	-0.2	-0.6	0.5	-1.0	-0.9	-0.2	-1.6	-0.7	0.4
Schizophrenia (2014)	0.5	1.2	2.7	-1.2	-1.6	-1.1	-0.3	1.0	-0.2	-1.6	-1.4	-1.2	-1.0	-0.9	0.3
Lung FVC	0.5	2.4	5.3	2.1	2.0	0.3	1.0	2.0	0.7	2.0	1.3	2.3	1.1	1.4	0.4
Average weekly spirits intake	0.5	0.6	2.1	0.5	0.2	0.6	1.4	1.1	-0.0	0.5	0.8	0.3	0.7	0.7	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	3.3	0.2	0.9	0.5	0.5	0.5	0.0	0.7	1.0	-0.3	1.8	0.6	-1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.2	0.1	-0.1	0.3	1.4	1.5	-0.3	0.0	0.2	-0.5	-0.7	-0.0	1.3
Impedance of leg (right)	0.5	2.4	6.8	2.6	2.2	0.2	1.4	0.6	1.7	1.4	1.7	1.3	1.2	1.7	0.9
Taking other prescription medications	0.5	0.8	4.9	0.4	0.8	0.9	0.7	2.2	0.6	0.7	0.4	0.7	1.1	0.4	0.3
Sitting height	0.5	3.8	8.5	2.6	1.9	-1.3	1.0	1.3	0.6	1.7	2.0	2.7	-0.7	2.9	2.7
Trunk fat mass	0.5	2.0	4.1	1.3	1.5	1.7	0.7	1.6	0.7	1.8	1.8	2.0	0.9	1.4	1.1
Hearing difficulty/problems with background noise	0.5	0.9	6.2	-0.5	-0.2	0.8	-0.5	2.5	-0.4	-0.1	0.0	-0.0	0.9	-0.3	-1.4
Allergy	0.5	1.0	4.5	0.1	-0.0	-0.6	-1.2	-2.1	-1.1	-0.6	-1.7	0.8	-0.6	-0.6	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.0	0.5	0.2	0.6	1.1	1.7	-1.0	0.1	-0.2	-0.2	-1.1	0.3	0.7
Hair/balding pattern: Pattern 3	0.5	0.7	2.3	1.1	0.7	0.4	0.7	1.5	0.6	0.5	0.2	0.8	-0.6	0.5	1.4
Depression (self-reported)	0.5	0.5	2.1	0.6	0.7	-0.6	0.6	1.5	-0.6	0.5	-0.2	0.5	1.2	-0.7	-0.2
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	0.8	1.0	1.0	0.6	0.6	0.5	0.7	0.7	-0.1	1.4	0.5	0.0
Birth weight	0.5	1.0	4.3	1.5	1.1	0.7	-0.3	1.1	0.4	0.8	0.6	2.1	0.9	0.9	0.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.8	-0.1	0.1	-0.3	0.9	1.3	-0.4	0.6	0.6	-0.5	1.3	0.9	-0.4
High blood pressure (siblings)	0.5	0.7	2.0	-1.1	-1.0	-0.6	-1.4	0.5	-1.1	-0.8	-1.0	-0.0	0.1	-0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	3.1	-0.0	0.1	-1.1	-0.7	-1.8	-0.6	-0.5	-0.5	-0.2	0.9	-0.3	-1.1
Health satisfaction	0.5	0.6	3.1	0.3	0.6	0.9	0.5	1.6	-0.0	0.1	-0.1	-0.2	1.8	-0.2	-0.2
Knee pain experienced in last month	0.5	0.8	4.0	-0.8	-0.4	0.4	-0.3	-0.4	-0.9	-0.9	-0.7	-2.0	-0.3	-0.9	-1.3
Illnesses of siblings: Diabetes	0.5	0.7	2.8	0.5	0.3	1.5	0.9	0.6	-0.2	0.4	0.4	0.4	-0.2	0.9	1.7
Loneliness, isolation	0.5	0.7	2.3	0.1	0.6	0.6	1.2	0.7	0.4	1.1	1.1	0.2	1.5	0.8	0.3
Diabetes diagnosed by doctor	0.5	0.8	3.5	0.2	0.5	-1.6	0.4	1.9	-0.1	1.1	0.7	0.7	0.4	0.2	1.1
Qualifications: nursing, teaching	0.5	0.7	4.2	-0.4	-0.5	2.1	0.6	-0.7	1.3	0.0	0.1	-0.4	-0.6	0.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.7	-1.2	-1.4	0.9	-0.2	-1.2	0.0	-1.1	-0.4	-1.6	-0.6	-0.4	-0.2
Mineral and other dietary supplements	0.5	0.7	2.8	-0.1	-0.1	-1.6	-0.2	0.0	-1.7	-0.4	-1.0	-0.5	-0.8	-0.9	0.0
Medication: Gliclazide	0.5	0.6	2.5	-0.5	-0.5	-1.6	-0.2	0.4	-0.7	-0.2	-0.9	-0.5	-0.2	-1.0	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	0.7	0.9	-1.0	-1.1	-0.2	-0.2	0.1	-0.7	0.4	1.1	-0.9	-0.8
Medication: Atorvastatin	0.5	0.6	2.3	0.4	0.7	-0.4	-0.8	1.1	1.1	0.1	0.7	0.5	0.9	-0.2	-1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.8	-0.7	-0.6	-0.3	-0.9	-2.0	-1.1	-0.9	-0.9	-0.6	-0.9	-0.4	-0.7
HbA1C	0.4	0.4	2.5	-1.3	-1.6	-0.3	0.6	0.3	0.2	-0.1	0.1	-0.3	-0.5	-0.2	0.2
Smoking Status	0.4	0.9	5.4	0.5	1.1	0.7	-0.5	2.3	-0.2	0.6	0.2	0.1	1.3	0.4	-0.8
Relative age voice broke	0.4	0.5	1.9	-0.7	-0.3	-0.9	-0.6	0.7	-0.6	-0.6	-0.2	-1.1	0.6	-0.2	-1.4
Supplements: Glucosamine	0.4	0.5	2.2	-0.4	-0.1	1.5	-0.3	0.2	0.9	0.1	1.0	-0.1	0.0	0.9	-0.8
Medication: Levothyroxine sodium	0.4	0.7	2.0	-0.7	-0.6	1.4	1.1	-0.3	0.5	0.5	1.3	-0.8	0.5	1.0	0.8
Past tobacco smoking	0.4	0.8	2.6	0.3	-0.1	1.1	0.9	-1.6	1.0	0.7	0.5	0.9	-0.9	0.7	0.9
Alcohol usually taken with meals	0.4	0.7	3.6	0.0	0.0	0.9	0.5	-1.9	1.2	0.2	1.1	-0.5	-0.2	0.7	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.3	-0.5	-0.1	-0.7	-0.7	0.9	-0.7	-0.3	-0.5	-0.4	1.0	-1.2	-1.5
Father’s age at death	0.4	0.5	1.6	-0.8	-1.0	-0.0	0.1	-0.7	0.2	-0.7	0.1	-1.1	-1.3	0.1	0.2
Illnesses of mother	0.4	0.5	2.3	0.6	-0.0	1.1	0.9	-0.0	0.4	-0.2	0.2	0.1	-1.5	0.2	1.0
Exposure to tobacco smoke at home	0.4	0.5	1.2	-0.1	-0.1	0.8	-1.0	-0.8	-0.5	-0.8	-0.6	-0.8	0.6	-1.1	-0.6
Headache pain in last month	0.4	0.6	2.0	-0.3	-0.0	1.4	0.9	1.0	-0.0	0.6	1.1	-0.2	0.7	1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.8	-0.2	-0.0	1.4	0.9	-0.4	0.5	0.8	1.7	-0.7	1.0	1.1	0.2
Leg fat percentage (right)	0.4	1.4	4.4	1.3	1.8	0.6	-0.1	1.0	0.7	1.4	1.0	1.6	2.1	-0.1	-0.3
Number of full brothers	0.4	0.5	2.6	-0.9	-0.4	0.7	0.6	-0.7	-1.6	-0.0	0.2	-0.9	0.1	0.3	0.2
Shortness of breath walking on level ground	0.4	0.4	1.9	0.7	0.5	1.4	1.2	0.5	-0.2	-0.0	-0.0	-0.3	-0.4	0.3	0.7
Qualifications: College or University degree	0.4	1.4	3.9	-1.8	-2.0	-1.5	-0.7	-0.6	-0.6	-1.2	-1.1	-1.0	-1.1	-0.8	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.7	0.6	0.8	0.3	-0.9	-0.6	0.3	0.1	-0.4	1.3	0.7	0.5	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.1	0.0	0.3	0.5	0.3	1.2	0.1	1.1	-1.1	-0.7	-0.2	-0.8
Alcohol intake frequency.	0.4	0.9	2.9	1.1	1.0	1.7	0.7	-0.7	1.3	0.7	0.4	0.9	0.4	0.6	1.1
Hypertension (Self-reported)	0.4	1.2	3.2	-1.2	-0.5	-0.1	-1.5	0.8	-0.9	-0.7	-1.4	-0.4	1.5	-1.8	-1.0
Hearing aid user	0.4	0.5	1.8	0.8	0.2	0.5	0.7	-0.6	-0.2	0.1	0.3	0.3	-1.1	0.4	1.4
Mother’s age at death	0.4	0.5	2.6	0.0	-0.0	-0.6	0.6	0.9	1.6	0.1	0.9	-0.6	-0.2	0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	3.3	-0.0	-0.3	0.7	0.2	0.2	1.8	-0.1	0.7	0.1	-0.4	0.6	0.9
Medication: Bendroflumethiazide	0.4	0.6	2.8	-0.6	-0.3	-0.4	-1.0	-0.6	-0.5	-0.7	-0.8	-0.8	0.1	-1.7	-0.9
Alcohol drinker status: Never	0.4	0.5	2.1	-0.7	-0.3	-0.8	-0.5	-1.2	0.2	0.4	0.0	0.0	1.5	-0.1	-0.9
Average weekly beer plus cider intake	0.4	0.6	1.4	-0.7	-1.0	-0.2	-0.3	0.4	-1.0	-1.0	-0.8	-0.7	-0.5	-1.2	-0.5
Risk taking	0.4	0.6	2.0	0.7	1.0	0.4	0.4	-1.4	0.1	0.6	0.9	-0.1	1.1	0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.0	1.2	0.4	0.7	1.4	-0.5	0.8	0.4	1.2	0.1	-1.7	1.5	1.1
Pain experienced in last month	0.4	0.6	2.6	0.1	-0.6	-0.7	-0.2	-1.1	0.3	-0.3	-0.5	0.7	-1.3	-0.3	1.6
Supplements: Calcium	0.4	0.4	1.6	-0.6	-0.4	0.3	-0.2	0.6	-0.2	-0.9	-0.0	-1.3	0.0	-0.8	-1.0
Schizophrenia (2018)	0.3	0.7	1.8	-1.2	-1.3	-0.5	-0.3	1.1	-0.1	-1.2	-1.1	-0.9	-0.5	-0.4	-0.2
Crohns Disease (2017)	0.3	0.7	2.8	0.8	0.8	-1.2	1.0	1.7	0.0	0.9	0.7	0.3	0.4	0.6	-0.3
Major Depression (MDD)	0.3	0.3	2.1	-0.1	-0.1	-1.5	-0.0	-0.1	-0.3	-0.1	-0.5	0.2	0.6	-0.7	-0.6
Reaction Time	0.3	0.7	2.5	-0.7	-1.1	1.6	1.1	-0.6	0.9	-0.3	0.3	0.2	-0.4	0.8	0.6
Fasting Glucose	0.3	0.4	2.2	-0.5	-0.1	-1.5	-0.4	0.7	-0.5	-0.1	-0.1	-0.6	0.3	-0.7	-0.7
LDL Cholesterol	0.3	0.5	2.2	-1.5	-1.3	-0.5	0.0	-0.1	-0.0	-0.5	0.1	-1.0	-0.7	-0.2	-0.1
Lupus	0.3	0.5	1.4	0.4	0.4	0.8	0.4	-1.2	0.8	0.6	-0.2	1.1	0.6	0.1	0.8
Blood White Count	0.3	2.5	7.2	-2.1	-2.5	0.2	1.1	2.1	-0.6	-0.8	0.6	-1.7	-2.7	1.2	0.0
Cardiovascular Disease	0.3	0.9	4.7	0.3	0.7	-1.0	-0.5	-0.2	-0.9	0.3	-1.2	0.9	2.2	-0.9	0.5
Townsend deprivation index at recruitment	0.3	0.5	2.1	0.6	0.4	0.6	1.5	0.7	0.5	0.6	-0.3	0.1	0.5	-0.3	1.1
Current tobacco smoking	0.3	0.5	1.6	0.4	0.8	0.8	-0.2	1.3	-0.3	0.8	0.2	0.1	1.2	0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.3	-0.5	-0.4	-0.4	0.4	0.7	-0.3	-0.1	0.0	-0.1	1.5	-0.3	-0.9
Age when periods started (menarche)	0.3	0.6	3.2	0.4	0.8	-0.4	0.0	-1.1	0.5	0.8	0.7	0.6	1.8	0.6	-0.0
Serious illness, injury or assault to yourself	0.3	0.3	1.3	0.0	0.3	1.1	0.5	1.1	-0.1	0.1	0.3	-0.7	0.4	-0.1	-0.5
High blood pressure	0.3	0.9	2.3	-1.2	-0.6	-0.4	-1.2	0.9	-0.6	-0.5	-1.2	-0.3	1.3	-1.5	-0.7
Qualifications: None of the above	0.3	0.7	1.6	1.1	1.0	1.1	0.7	1.1	0.5	0.7	0.1	1.3	0.5	0.3	1.0
Trunk fat-free mass	0.3	1.9	4.7	-0.9	-0.3	-1.6	-1.9	-0.9	-2.2	-1.2	-1.1	-0.9	-0.6	-1.6	-1.9
Medication: Lansoprazole	0.3	0.3	0.7	0.3	0.8	-0.3	0.3	0.6	-0.8	0.6	0.6	-0.7	0.8	0.3	-0.4
Trunk predicted mass	0.3	1.9	4.7	-0.9	-0.3	-1.6	-1.8	-1.0	-2.2	-1.2	-1.1	-0.9	-0.7	-1.7	-1.8
Length of working week for main job	0.3	0.4	1.0	-1.0	-0.8	-0.4	-0.6	-0.6	-0.9	-0.5	-0.3	-0.7	0.0	-0.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	4.2	0.0	0.2	0.1	0.4	0.5	-0.2	0.1	-0.3	-0.2	2.1	-0.4	0.0
Loud music exposure frequency	0.3	0.3	2.4	0.3	0.5	-0.4	0.3	1.6	0.6	0.4	0.2	-0.4	0.5	-0.1	-0.1
Comparative body size at age 10	0.3	0.7	2.1	-0.6	-0.1	-0.7	-0.6	0.7	-1.5	-0.3	-0.2	-1.1	0.2	-1.3	-1.2
Neck or shoulder pain in last month	0.3	0.4	1.6	-0.5	-0.2	0.6	0.3	0.8	0.3	-0.1	0.5	-0.7	1.2	0.3	-0.8
Whole body fat mass	0.3	1.1	2.2	0.8	1.2	1.2	0.3	1.4	0.2	1.3	1.2	1.5	0.9	0.7	0.7
Leg pain on walking	0.3	0.4	1.9	1.4	1.1	-0.4	-0.3	0.2	-0.2	0.4	0.3	0.8	0.3	0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	2.3	-0.2	0.5	-1.0	0.1	0.1	-0.3	0.2	0.3	-0.5	0.3	-0.1	-1.5
Friendships satisfaction	0.3	0.4	1.3	-0.0	0.1	-0.5	-0.3	-0.2	-0.3	-0.8	-0.7	-1.0	0.2	-1.2	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.3	0.2	0.0	-0.2	-0.9	-0.3	-0.4	-0.8	-1.1	0.1	0.1	-0.6	0.1
High cholesterol (Self-reported)	0.3	0.5	1.4	0.3	0.8	-0.4	-1.1	-0.3	-0.5	0.0	-0.4	0.0	1.1	-1.0	-1.2
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.8	0.6	0.5	0.5	-0.4	0.4	0.3	0.1	0.7	0.1	0.3	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	0.5	0.4	-1.0	-0.1	-0.1	0.8	0.3	0.5	0.9	0.1	0.3	-0.7
Rheumatoid Arthritis	0.2	0.3	0.8	-0.0	0.2	-0.6	-0.3	-0.9	0.7	0.1	0.1	-0.2	0.8	-0.5	-0.5
Blood Red Count	0.2	1.5	8.2	-1.4	-1.0	-0.4	-0.3	-2.9	-1.4	-0.9	-0.7	-1.2	-0.2	-0.6	-1.3
Systolic Blood Pressure	0.2	1.0	3.6	-1.2	-1.3	-0.7	-0.9	-0.0	-0.0	-0.8	-1.9	0.6	0.2	-1.7	0.3
Hypothyroidism (self reported)	0.2	0.5	2.4	-0.7	-0.9	0.5	0.2	-1.6	-0.3	-0.3	0.6	-1.3	-0.3	0.1	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.3	-0.0	0.4	0.0	-0.1	-0.7	-0.4	-0.4	-0.3	1.1	-0.4	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	-0.4	-0.1	0.1	0.1	-0.6	-0.3	-0.4	-0.5	0.6	-0.2	-0.3
Impedance of leg (left)	0.2	1.2	2.8	1.7	1.3	-0.1	1.3	1.0	1.1	0.9	1.4	0.7	0.4	1.4	0.9
Arm fat percentage (right)	0.2	0.7	2.1	0.6	1.0	1.1	-0.2	0.7	0.1	1.1	1.0	1.4	1.0	0.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.3	-0.4	0.1	-0.4	0.6	-0.5	-0.5	-0.8	-0.6	0.6	-0.9	-0.5
Arm fat-free mass (right)	0.2	0.9	2.4	-0.8	-0.1	-1.0	-1.4	0.0	-1.6	-0.8	-0.7	-0.6	-0.4	-1.4	-1.3
Leg fat mass (right)	0.2	0.9	2.1	0.9	1.5	0.5	-0.1	1.2	-0.0	1.1	0.9	1.3	1.4	0.0	-0.2
Arm predicted mass (right)	0.2	1.0	2.6	-1.0	-0.4	-1.1	-1.2	-0.1	-1.6	-1.0	-0.8	-0.8	-0.8	-1.4	-1.0
Number of full sisters	0.2	0.3	1.7	0.6	0.8	-0.1	-0.3	-0.2	-0.0	0.2	-0.2	0.3	1.3	-0.2	-0.1
Age at last live birth	0.2	0.3	1.6	-0.3	-0.4	0.4	0.7	-0.1	0.1	-0.2	0.4	-0.9	-1.3	0.5	-0.3
Illnesses of father: Heart disease	0.2	0.2	1.0	-0.1	0.3	0.7	-1.0	-0.5	-0.2	-0.0	-0.2	0.5	-0.4	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.0	0.5	0.3	-1.4	-0.6	0.8	-1.3	-0.4	0.3	0.0	-0.7	0.5	-0.5
Whole body fat-free mass	0.2	0.9	3.3	-0.7	-0.0	-1.1	-1.4	-0.3	-1.8	-0.6	-0.6	-0.4	-0.4	-1.2	-1.3
Arm fat percentage (left)	0.2	0.8	2.2	0.5	0.7	1.5	0.2	0.7	0.3	1.1	1.1	1.4	0.8	0.6	0.6
Osteoporosis (self-reported)	0.2	0.3	1.4	-0.7	-0.5	1.2	-0.2	0.1	0.3	-0.0	-0.0	-0.2	0.7	-0.2	-0.3
Osteoarthritis (self-reported)	0.2	0.3	1.2	-0.2	-0.2	0.3	0.2	1.1	0.9	0.3	0.0	0.1	0.7	0.2	0.5
Smoking status: Current	0.2	0.4	1.1	0.1	0.5	0.9	-0.5	1.0	-0.3	0.5	-0.1	-0.2	1.1	-0.1	-0.7
Leg fat percentage (left)	0.2	0.7	2.2	0.6	1.1	0.5	-0.2	1.1	0.3	1.0	0.7	1.2	1.5	-0.2	-0.3
Arm fat-free mass (left)	0.2	1.2	2.7	-0.4	0.3	-1.6	-1.6	-0.2	-1.6	-0.7	-0.8	-0.5	-0.4	-1.5	-1.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	0.1	0.1	-0.5	-0.5	-0.7	-0.3	0.3	0.8	0.5	-0.1	0.6	-0.9
Leg fat mass (left)	0.2	0.6	2.3	0.5	1.0	0.5	-0.1	1.5	-0.3	0.9	0.8	0.9	1.0	-0.1	-0.3
Arm predicted mass (left)	0.2	1.2	2.9	-0.5	0.2	-1.5	-1.5	-0.3	-1.6	-0.9	-0.9	-0.7	-0.4	-1.7	-1.4
Blood Eosinophil Count	0.1	0.6	1.5	-0.4	-0.9	-1.0	0.6	1.2	0.4	0.0	0.4	0.5	-0.1	1.1	1.0
BMI	0.1	0.7	2.0	0.4	0.9	-0.8	0.0	0.7	0.4	1.3	1.0	1.4	1.1	0.4	0.5
Height	0.1	1.2	3.4	1.6	1.8	-1.8	-1.6	0.8	-1.5	-0.3	-0.4	0.1	-0.6	-0.0	-0.2
Hair Pigment	0.1	1.9	4.8	-1.8	-2.2	-1.2	-0.0	-0.2	-0.6	-1.5	-1.5	-2.0	0.5	-1.8	-0.5
Diabetes (mother)	0.1	0.1	0.5	-0.7	-0.6	0.2	0.5	0.0	-0.1	0.2	0.2	-0.5	0.1	-0.1	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.1	0.4	0.1	0.2	-0.6	-0.4	-0.3	-0.5	-0.3	0.3	-0.7	-0.2
High blood pressure (mother)	0.1	0.2	0.7	-0.0	0.3	-0.6	0.0	-0.4	-0.4	0.0	-0.6	-0.1	0.8	-0.3	-0.3
Body mass index (BMI)	0.1	0.3	1.0	-0.1	0.5	0.4	-0.6	0.5	-0.0	0.7	0.2	0.9	1.0	-0.6	-0.3
Had menopause	0.1	0.1	1.0	0.1	0.3	0.5	-0.2	-0.1	1.0	0.3	0.2	0.2	-0.0	0.2	-0.1
Mouth/teeth dental problems	0.1	0.2	0.6	-0.7	-0.3	-0.5	-0.7	0.8	0.1	-0.1	0.1	0.1	-0.4	0.2	-0.5
Illnesses of siblings	0.1	0.2	1.2	0.2	0.1	-0.7	0.0	-1.1	0.2	-0.2	-0.5	-0.1	-0.3	-0.4	-0.2
Weight	0.1	0.5	1.2	0.5	1.0	0.0	-0.6	1.1	-0.4	0.8	0.7	1.1	0.5	-0.0	-0.1
Hip circumference	0.1	0.6	1.9	0.8	1.3	0.6	-0.6	1.0	-0.3	0.9	0.8	1.4	0.4	0.2	-0.1
Arm fat mass (right)	0.1	0.3	1.0	0.2	0.7	0.5	-0.5	0.5	-0.4	0.7	0.5	1.0	0.7	-0.0	-0.1
Standing height	0.1	0.8	1.6	1.2	1.1	-0.5	0.1	1.2	-0.7	0.3	1.0	0.5	-1.1	1.3	0.6
Comparative height size at age 10	0.1	0.7	3.7	0.5	0.5	-1.0	-0.9	1.2	-1.9	-0.1	-0.3	0.3	-0.6	-0.1	-0.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.6	-0.2	0.1	0.0	0.2	0.2	-0.5	0.3	0.3
Smoking status: Previous	0.1	0.2	1.8	-0.1	0.2	-0.5	-0.1	1.3	-0.5	-0.1	0.2	-0.1	0.4	0.3	0.0
Leg fat-free mass (right)	0.1	0.3	2.0	-0.6	-0.1	-0.3	-0.6	0.9	-1.4	0.1	0.1	0.2	-0.2	-0.1	-0.2
Average weekly red wine intake	0.1	0.2	0.7	0.5	0.3	-0.8	0.0	-0.1	0.5	0.3	0.2	0.4	-0.1	0.2	0.5
Whole body water mass	0.1	0.8	3.0	-0.6	0.0	-1.0	-1.3	-0.2	-1.7	-0.6	-0.6	-0.3	-0.4	-1.1	-1.2
Leg predicted mass (right)	0.1	0.3	2.1	-0.6	-0.1	-0.3	-0.6	0.9	-1.4	0.1	0.0	0.3	-0.3	-0.2	-0.2
Financial situation satisfaction	0.1	0.1	0.3	0.3	0.5	-0.0	0.4	0.4	-0.2	0.0	-0.3	-0.1	0.5	-0.2	0.0
Basal metabolic rate	0.1	0.5	2.4	-0.3	0.2	-0.8	-1.1	0.2	-1.6	-0.2	-0.3	0.1	-0.1	-0.8	-0.9
Diastolic blood pressure, automated reading	0.1	0.3	1.0	-0.1	0.2	-0.3	-0.3	1.0	0.3	0.5	-0.4	0.7	1.0	-0.8	-0.0
Cholesterol lowering medication	0.1	0.2	1.0	-0.2	-0.0	-1.0	-0.5	0.0	0.0	0.3	-0.0	-0.1	0.7	-0.7	-0.0
Tanning	0.0	0.3	1.2	-0.0	0.1	-1.1	-0.1	0.9	0.5	0.2	0.3	0.4	-0.3	0.8	0.6
Leg fat-free mass (left)	0.0	0.2	1.2	-0.0	0.4	-0.2	-0.4	0.9	-1.1	0.3	0.3	0.6	0.1	0.0	-0.0
Leg predicted mass (left)	0.0	0.2	1.2	-0.0	0.4	-0.1	-0.4	0.8	-1.1	0.3	0.2	0.6	0.1	-0.0	-0.1
Waist circumference	0.0	0.2	0.5	-0.5	0.0	0.1	-0.4	0.7	-0.4	0.2	0.1	0.4	0.5	-0.7	-0.2
Arm fat mass (left)	0.0	0.2	0.7	0.0	0.4	0.6	-0.5	0.3	-0.5	0.4	0.3	0.8	0.5	-0.2	-0.0

Hub : Genes

RHBDD3

Models

Trait associations