Hub : Genes

CHEK2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1370 0.0470 5.3e-04 0.026 NA 0.031 NA 0.031 1.6e-02 NA 9.1e-03 NA 9.1e-03
2 GTEx Cells Transformed fibroblasts 0.1490 0.0470 1.9e-04 0.160 NA 0.143 NA 0.152 5.0e-12 NA 7.8e-11 NA 1.7e-11
3 GTEx Liver 0.2020 0.0860 4.8e-03 0.059 NA 0.043 NA 0.075 9.9e-03 NA 2.4e-02 NA 3.9e-03
4 GTEx Nerve Tibial 0.1515 0.0543 3.3e-03 0.136 NA 0.125 NA 0.114 7.9e-10 NA 3.9e-09 NA 1.8e-08
5 GTEx Testis 0.7210 0.0420 0.0e+00 0.644 NA 0.622 NA 0.639 1.5e-36 NA 1.5e-34 NA 4.4e-36
6 METSIM Adipose 0.0519 0.0198 5.1e-05 0.040 0.039 0.037 0.040 0.033 1.2e-06 1.3e-06 2.3e-06 1.0e-06 9.2e-06
7 YFS Blood 0.0244 0.0092 9.3e-06 0.023 0.012 0.017 0.012 0.018 4.3e-08 7.1e-05 2.1e-06 4.3e-05 1.3e-06
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.0770 0.0450 4.8e-03 0.026 0.040 0.031 NA 0.028 1.3e-02 2.5e-03 6.6e-03 NA 9.6e-03
9 TCGA Liver Hepatocellular Carcinoma 0.2380 0.0750 1.5e-09 0.219 0.223 0.241 NA 0.237 1.2e-10 7.8e-11 1.1e-11 NA 1.8e-11
10 TCGA Thyroid Carcinoma 0.1090 0.0560 5.9e-03 0.031 0.014 0.016 NA 0.022 4.4e-04 1.4e-02 1.1e-02 NA 2.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.6 1.0 2.2 -0.1 1.0 1.5 -1.1 0.8 1.1 -1.2 -0.1 1.2 0.9
Bipolar Disorder or Schizophrenia 0.2 0.5 2.1 0.2 -0.4 -0.6 -0.1 -0.1 -0.4 -0.3 -1.5 -0.6 -1.1
Depressed Affect (Nagel 2018) 0.6 1.3 3.4 -0.0 1.2 -1.5 -1.6 0.9 -1.3 -0.1 -0.1 -1.0 -1.8
Depression (Nagel 2018) 0.6 0.9 4.7 0.5 -0.6 -0.9 -0.6 0.2 -2.2 0.2 -0.7 -1.2 -0.7
Intelligence (Savage-Jansen 2018) 0.6 1.9 6.9 0.1 1.0 1.4 0.0 0.4 2.2 -2.6 1.9 0.6 0.3
Neuroticism (Nagel 2018) 0.5 1.1 5.0 -0.4 -0.3 -0.6 -0.8 -0.0 -2.2 0.9 -1.8 0.5 -0.7
Schizophrenia (2018) 1.0 2.0 4.8 0.3 -1.3 -2.0 0.7 -0.8 -1.4 0.5 -1.8 -1.7 -2.2
Schizophrenia vs Biploar Disorder 1.8 2.4 8.1 0.6 -1.0 -2.5 1.0 -0.5 -1.1 0.4 -0.0 -2.9 -2.4
Worry (Nagel 2018) 0.7 1.4 5.3 -0.6 -0.6 0.7 -0.5 -0.2 -1.7 1.0 -2.3 1.7 0.6
Alzheimer’s Disease (in mother) 1.5 1.8 3.7 -0.8 -1.5 0.3 1.6 -1.9 -1.1 1.9 -1.5 0.1 1.2
Alzheimer’s Disease (in father) 0.8 0.9 2.6 1.4 -0.6 -1.3 0.3 -0.3 -0.1 -0.0 0.2 -1.6 -1.5
Alzheimer’s Disease (including proxy) 0.9 1.3 3.4 -0.1 -1.3 -0.0 1.6 -1.8 -0.9 1.5 -0.9 -0.2 1.0
Crohns Disease (2017) 1.7 3.7 10.5 -2.4 3.1 -1.0 -2.6 3.2 -1.0 0.9 -0.7 0.1 -1.3
Irritable Bowel Disease (IBD) 1.3 3.0 9.6 -1.9 2.2 -1.0 -2.6 3.1 -1.1 0.8 -0.4 0.2 -1.6
Ulcerative Colitis (UC) 0.5 1.0 3.9 -0.1 0.7 -0.3 -1.9 2.0 -0.0 0.1 0.4 0.6 -1.1
Major Depression (MDD) 1.5 1.9 6.4 -1.1 0.1 0.8 0.1 0.5 -1.7 1.8 -2.5 1.5 1.3
Reaction Time 1.6 3.1 9.1 -2.2 -0.8 1.7 0.4 -1.0 -1.3 1.6 -0.8 3.0 2.8
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.6 -0.0 -1.6 0.9 1.4 -1.3 1.3 -1.9 1.4 0.1 0.5
Breast Cancer 8.4 20.2 68.1 4.3 0.1 3.8 0.5 -0.4 7.7 -5.4 8.2 0.8 3.5
Ovarian Cancer 5.3 7.0 19.4 -3.8 1.5 -1.4 -0.7 0.7 -3.6 4.3 -4.4 0.4 -0.1
Prostate Cancer 3.1 4.4 13.6 -1.9 -0.3 -2.4 -0.7 0.3 -3.7 2.8 -2.6 -1.0 -2.2
Age at First Birth 2.2 3.2 10.7 1.0 0.5 3.3 0.3 -0.5 1.4 -2.0 0.9 2.7 2.5
Bipolar Disorder (2011) 0.5 0.5 1.6 0.7 1.3 0.2 -0.7 0.8 0.4 -0.7 0.6 0.3 -0.4
Body Mass Index (BMI) (2010) 0.6 0.8 2.3 -1.0 -0.7 -1.0 -0.0 0.0 -1.5 0.2 0.1 -1.5 -0.8
Coronary Artery Disease (CAD) 1.7 2.1 5.2 2.2 0.7 0.9 -1.0 0.9 2.3 -2.0 1.8 0.2 -0.5
Crohns Disease (2012) 0.5 0.8 3.0 -1.7 1.4 0.1 -0.6 1.2 -0.9 0.1 -0.3 0.8 -0.2
Mean Putamen Volume 1.4 1.6 5.8 -0.9 0.4 -2.4 -0.2 0.8 -0.6 1.0 -0.5 -2.2 -1.7
Fasting Glucose 1.5 1.8 5.3 1.1 -2.3 -0.5 1.8 -1.9 0.1 -0.7 -0.1 -1.9 -0.3
HbA1C 0.2 0.2 1.1 -0.2 0.1 0.1 -0.2 0.2 -1.1 0.2 -1.0 0.3 0.0
HDL Cholesterol 0.8 1.3 3.9 -0.6 -0.9 1.2 1.1 -1.1 -0.3 0.7 -2.0 0.7 1.8
LDL Cholesterol 0.1 0.2 0.9 0.2 -0.3 -0.9 -0.0 0.2 -0.2 0.1 0.3 -1.0 -0.5
Lupus 1.1 1.6 4.5 1.1 -0.7 -1.4 0.5 -0.2 0.4 -1.6 0.9 -2.1 -2.0
Neuroticism (2016) 1.8 2.6 5.7 -0.0 0.7 -2.4 -0.6 0.7 -2.1 2.2 -2.1 -1.3 -1.9
Primary Biliary Cirrhosis 0.9 1.2 3.9 2.0 0.9 -0.3 -1.1 0.9 0.7 -1.2 0.8 -1.4 -0.9
Rheumatoid Arthritis 1.3 1.9 5.3 0.7 0.1 1.4 -0.1 0.1 2.1 -2.3 1.6 1.7 0.7
Schizophrenia (2014) 1.2 2.7 6.4 0.9 -1.2 -2.3 0.5 -0.5 -1.6 0.5 -2.2 -2.2 -2.5
Triglycerides 0.4 0.6 2.0 -0.1 -0.9 -1.2 0.2 -0.5 -0.7 0.3 -0.1 -1.4 -0.9
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.3 0.9 -1.9 -2.1 1.9 -1.8 -1.1 1.5 -0.8 -2.0 -1.1
Ulcerative Colitis 0.6 0.9 3.5 -0.4 0.8 -0.4 -1.9 1.8 -0.6 0.6 0.0 0.8 -0.6
Blood Eosinophil Count 0.6 4.2 13.5 -2.9 0.5 -1.4 -0.6 0.9 -3.7 2.2 -3.2 -1.2 -0.6
Blood Platelet Count 1.3 15.2 26.8 -4.7 5.2 -2.6 -4.5 4.2 -3.3 4.4 -5.0 -0.7 -1.7
Blood Red Count 1.3 12.5 27.6 -5.2 3.5 2.2 -4.3 4.0 -2.0 2.6 -3.4 4.2 2.6
Blood White Count 0.4 3.0 7.9 -1.3 1.9 -0.4 -2.3 2.8 -0.6 -2.6 0.3 -0.8 -2.0
Heel T-Score 2.5 20.2 65.1 -8.1 -3.3 5.1 1.6 -1.7 2.0 -4.7 6.4 2.3 4.8
BMI 0.3 2.0 5.8 -0.3 -1.7 -1.8 1.0 -1.2 -1.6 0.1 0.3 -2.4 -1.8
Height 0.2 3.2 13.7 -0.2 -0.8 -1.7 1.1 -1.0 0.9 -1.8 1.0 -3.7 -2.7
Waist Hip Ratio (WHR) 3.6 16.1 55.8 -4.8 -0.1 -4.0 -2.7 2.4 -7.5 5.1 -4.1 -1.8 -2.5
Systolic Blood Pressure 0.7 3.6 7.1 1.9 1.0 -1.3 -2.6 2.4 -2.3 -0.4 -2.7 -0.3 -2.2
Smoking Status 2.6 6.1 25.3 1.5 -1.4 -3.6 1.7 -1.8 -0.5 -0.4 0.3 -5.0 -3.6
Allergy or Eczema 3.3 8.7 19.3 -4.3 1.3 -0.3 -2.0 2.1 -4.4 3.9 -4.2 2.1 1.4
Cardiovascular Disease 1.4 4.5 16.8 4.1 1.0 -1.9 -1.4 1.6 0.1 -2.0 1.0 -2.0 -3.3
Hypothyroidism (self reported) 0.6 1.4 5.8 -2.4 0.2 -0.6 -0.7 0.8 -1.1 2.1 -0.5 -0.1 0.9
Respiratory disease 0.8 1.7 6.2 -2.5 -0.3 -0.9 0.5 -0.7 -1.8 1.2 -2.2 -0.4 -0.2
Type 2 Diabetes (T2D) (2018) 1.8 3.4 12.9 3.6 0.1 -0.7 1.3 -0.7 1.6 -2.3 1.6 -1.9 -2.1
Lung FEV1/FVC ratio 0.9 4.8 8.4 0.9 1.9 2.9 -1.8 1.6 2.3 -2.7 2.7 2.5 1.8
Lung FVC 1.3 6.4 14.7 -1.9 0.6 -3.3 -1.1 0.6 -3.2 1.9 -3.1 -3.8 -2.9
Neuroticism 0.3 0.7 1.9 0.5 0.8 -0.3 -1.4 0.6 -1.2 0.4 -0.9 0.8 -0.5
Chronotype (morning person) 1.3 3.1 10.3 -2.4 0.4 -0.3 -0.8 0.1 -2.0 3.2 -2.8 1.1 0.7
Hair Pigment 0.1 3.7 15.0 -1.5 -0.5 -0.8 -1.2 1.1 -3.9 2.5 -3.1 0.1 0.2
Tanning 0.1 1.8 7.7 -2.2 0.0 -0.8 -0.3 -0.2 -1.6 2.8 -1.4 0.1 0.3
Hand grip strength (left) 0.4 0.9 3.9 0.7 -1.0 -0.6 0.5 -0.8 -0.1 -1.4 0.0 -2.0 -0.9
Number of treatments/medications taken 2.5 4.5 8.1 0.9 2.2 -2.8 -2.7 2.6 -1.3 2.0 -1.5 -1.7 -2.6
Average weekly spirits intake 0.6 0.7 2.5 -0.1 -1.6 0.4 0.7 -0.8 -1.3 0.6 -0.8 0.1 0.8
Sensitivity / hurt feelings 1.6 2.7 6.9 -0.3 0.3 -2.3 -0.5 0.3 -2.2 2.2 -2.6 -1.3 -1.8
Frequency of depressed mood in last 2 weeks 1.5 2.1 5.7 -0.1 0.6 -1.7 -1.7 1.4 -2.4 1.2 -1.3 -1.1 -1.7
Hearing difficulty/problems: Yes 1.0 1.5 5.4 0.1 -0.6 -1.1 0.1 -0.3 -2.3 1.2 -2.3 -0.9 -0.7
Relative age of first facial hair 0.5 1.1 4.5 0.9 -0.9 -1.0 1.1 -0.7 -0.4 1.0 -2.1 -1.0 -0.5
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 4.6 2.1 -0.0 0.2 -0.1 0.1 1.0 -2.1 2.0 -1.1 -0.6
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.0 1.8 -1.1 1.3 2.1 -2.2 0.9 -1.0 0.5 -0.1 1.1
Ever had hysterectomy (womb removed) 0.2 0.2 1.0 -0.0 0.1 0.5 0.0 0.1 -0.3 -0.4 -1.0 -0.1 0.4
Systolic blood pressure, automated reading 1.4 4.0 8.9 1.3 1.4 -2.4 -2.2 2.2 -2.2 0.7 -2.2 -1.5 -3.0
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 8.3 2.9 0.1 0.2 0.0 -0.1 0.9 -2.0 1.7 -0.6 -0.8
Angina 2.1 2.8 5.4 -0.6 -2.0 -1.2 2.3 -2.3 -1.8 1.2 -2.0 -1.6 -0.6
Medication for hormone replacement therapy 1.0 1.1 4.2 0.7 0.0 2.1 0.3 -0.1 -0.2 -1.2 -0.0 1.5 1.6
Vitamin and mineral supplements 0.3 0.4 1.4 -0.6 0.9 1.2 -0.3 0.1 0.4 -0.7 -0.6 0.6 0.7
Supplements: Zinc 0.5 0.5 1.5 -1.2 0.3 0.1 -0.8 1.2 -0.5 1.0 0.1 0.3 0.4
Medication: Co-codamol 1.4 1.6 3.8 0.7 1.2 -1.9 -0.9 1.1 -0.0 1.3 -0.5 -1.9 -1.7
Medication: Metformin 1.5 2.1 8.5 2.9 1.2 -0.3 -0.4 0.9 1.5 -2.1 1.5 -0.6 -1.1
Diabetes (father) 1.5 1.9 5.2 0.1 0.0 2.0 0.1 0.2 1.2 -2.3 1.5 2.2 1.0
Diabetes (mother) 1.0 1.2 3.8 0.9 0.3 1.4 -0.8 0.7 1.2 -1.3 1.1 2.0 0.4
Severe depression (siblings) 1.5 1.7 4.4 -1.5 -0.5 -1.3 0.3 0.1 -1.9 2.1 -1.4 -1.4 -0.7
Pack years adult smoking proportion 0.5 0.8 2.6 1.6 -1.1 -0.1 0.9 -1.2 0.2 -0.9 0.6 -0.6 -0.1
Impedance of leg (right) 0.4 2.0 5.6 -0.4 -1.0 -1.1 2.2 -2.4 -0.7 1.3 -1.8 -1.5 -0.5
Leg fat-free mass (left) 0.4 2.3 7.5 0.5 -0.0 -2.0 -0.1 0.3 -0.6 -1.4 1.3 -2.6 -2.7
Trunk fat percentage 0.5 2.0 5.8 0.9 -1.2 -1.5 1.6 -1.6 0.1 -1.0 -0.2 -2.4 -1.9
Hand grip strength (right) 0.3 0.9 2.5 0.8 -1.6 -0.7 1.2 -1.3 -0.5 -0.3 -0.9 -0.9 -0.7
Townsend deprivation index at recruitment 0.8 1.2 3.7 1.5 -0.3 -1.8 0.2 -0.1 -0.2 0.4 -0.7 -1.9 -1.3
Current tobacco smoking 1.3 2.2 7.7 2.2 -0.5 -2.1 -0.0 0.1 0.3 -0.5 1.2 -2.8 -1.7
Average weekly fortified wine intake 0.3 0.4 1.8 -0.6 -0.2 0.3 -0.5 0.2 -1.3 0.8 -0.2 -0.2 0.7
Maternal smoking around birth 1.6 2.4 6.8 2.6 -1.1 -1.5 0.9 -1.1 0.2 -1.2 -1.0 -2.3 -1.9
Fed-up feelings 0.5 0.9 2.6 0.5 0.7 -1.5 -1.1 0.9 -0.7 -0.1 0.4 -1.0 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 3.3 1.4 -0.8 -0.6 0.2 -0.4 -1.8 -0.1 -0.5 -0.6 -0.4
Relative age voice broke 0.5 0.7 2.4 1.5 0.9 -1.0 -0.4 0.4 0.8 0.5 -0.5 -0.7 -1.1
Taking other prescription medications 3.0 4.7 12.3 0.7 0.4 -3.5 -0.8 0.6 -2.2 2.4 -2.2 -3.1 -2.8
Age when periods started (menarche) 0.6 1.4 4.1 -1.4 0.6 2.0 -0.6 0.3 -0.2 -0.6 0.4 2.0 1.6
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.9 0.6 1.2 -0.5 -1.7 1.4 -1.1 -0.2 -1.1 -0.6 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.4 15.1 -3.9 -1.6 2.7 0.6 -0.5 0.1 -2.0 1.9 1.9 2.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 0.4 0.9 -0.6 -0.8 0.9 -0.1 0.8 -0.9 0.1 -0.3
Qualifications: CSEs or equivalent 1.4 1.9 7.0 -1.1 -0.2 -1.2 0.2 -0.5 -2.2 2.6 -1.8 -0.6 -0.6
Serious illness, injury or assault to yourself 2.0 2.4 6.4 0.6 1.1 -2.3 -0.2 0.1 -1.0 1.5 -1.1 -2.4 -2.5
High blood pressure 2.0 5.7 22.2 4.7 1.3 -2.3 -1.9 1.8 0.5 -1.3 -0.0 -2.4 -3.6
Hayfever, allergic rhinitis or eczema 2.8 6.2 13.6 -3.7 -0.6 0.7 0.1 0.4 -3.3 3.2 -3.6 2.8 2.4
Multivitamins +/- minerals 0.5 0.7 1.9 0.6 0.3 -1.4 -0.7 0.8 -0.3 0.6 0.8 -1.0 -1.1
Stomach or abdominal pain in last month 1.0 1.3 3.2 -1.5 0.0 0.9 0.1 -0.2 -1.0 1.2 -1.8 1.4 1.5
Supplements: Glucosamine 0.4 0.6 1.7 0.5 0.4 -0.8 -0.6 0.6 1.3 0.4 1.1 -1.0 -0.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.8 1.2 0.4 0.6 -0.5 1.1 0.5 -1.4 0.8 0.6 -0.4
Medication: Atenolol 0.9 1.1 1.9 1.2 -0.9 -1.1 1.4 -1.1 -0.9 0.7 -0.9 -1.4 -0.7
Medication: Levothyroxine sodium 0.4 0.7 2.2 -1.0 -0.3 -0.5 0.2 -0.2 -0.9 1.5 -1.3 0.1 0.6
Sitting height 0.5 3.4 15.2 -3.9 0.0 -1.8 0.2 -0.2 -2.3 0.4 -0.5 -2.4 -2.0
Chronic bronchitis/emphysema (father) 0.6 0.6 1.7 -0.7 -0.8 1.3 0.3 -0.3 0.1 -0.2 0.3 1.3 1.3
High blood pressure (mother) 0.2 0.3 2.0 1.4 0.4 -0.3 0.3 0.1 0.1 -0.6 -0.2 -0.5 -0.5
Body mass index (BMI) 0.3 1.1 3.7 0.3 0.2 -1.7 -0.4 0.4 -1.0 -0.4 0.0 -1.8 -1.9
Impedance of leg (left) 0.5 2.4 6.4 -1.0 -1.1 -1.0 1.9 -2.2 -1.4 2.0 -2.5 -0.9 -0.1
Leg predicted mass (left) 0.4 2.3 7.5 0.5 0.0 -2.0 -0.1 0.3 -0.6 -1.5 1.4 -2.6 -2.7
Trunk fat mass 0.6 2.4 9.0 0.4 -0.7 -2.1 1.1 -1.1 -0.5 -1.0 -0.0 -3.0 -2.6
Waist circumference 1.1 4.1 9.2 -1.1 0.5 -3.0 -1.3 1.1 -2.9 1.2 -1.2 -2.7 -2.9
Number of incorrect matches in round 0.2 0.3 1.1 1.1 -0.0 -0.3 0.7 -0.3 0.4 0.5 0.6 0.1 -0.1
Past tobacco smoking 2.3 4.2 12.1 -0.5 1.4 2.7 -2.1 2.5 1.4 -0.9 1.3 3.5 2.3
Alcohol usually taken with meals 3.4 5.5 11.6 -0.3 0.8 3.3 -1.7 1.6 2.4 -3.4 3.3 2.6 1.9
Nervous feelings 0.8 1.5 6.4 0.8 0.9 -0.6 -1.3 1.3 -1.2 0.9 -2.5 0.4 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.0 0.9 0.1 -0.8 -0.9 0.2 -1.4 0.7 -1.0 -0.5 -0.9
Hearing difficulty/problems with background noise 0.9 1.4 5.2 1.6 0.2 -1.5 -0.4 0.2 -0.9 -0.0 -0.7 -2.3 -1.5
Hair/balding pattern: Pattern 2 0.9 1.1 3.9 0.6 -1.0 -0.2 0.7 -1.2 1.3 -1.4 2.0 -0.1 -0.6
Had menopause 1.5 1.9 4.5 0.7 -1.0 1.6 0.8 -0.9 2.0 -1.4 2.1 0.6 1.4
Had other major operations 0.9 1.1 2.2 -1.1 1.1 -0.6 -1.3 1.5 -1.5 1.3 -0.5 -0.4 -0.1
Forced vital capacity (FVC) 1.2 4.5 12.7 -1.4 0.1 -3.1 -0.3 -0.2 -2.3 1.0 -2.1 -3.6 -3.1
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.9 18.0 -4.2 -1.7 2.5 1.3 -1.3 0.3 -2.7 2.2 1.3 2.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.7 -1.0 -0.0 -0.9 -0.3 0.4 -1.3 1.9 -1.0 -0.5 0.2
Qualifications: None of the above 0.6 1.3 2.6 0.2 0.3 -1.6 0.2 -0.6 -1.2 1.1 -1.6 -1.6 -1.4
Financial difficulties in last 2 years 0.9 1.3 3.2 0.0 1.0 -0.9 -1.5 1.7 -1.1 -0.8 -0.1 -0.8 -1.8
Mouth/teeth dental problems 0.7 1.0 3.4 0.6 1.8 0.5 -0.5 1.0 1.4 -0.8 1.3 0.4 -0.4
Heart attack 0.3 0.4 0.9 0.2 -0.9 0.4 1.0 -1.0 0.3 -0.9 0.3 -0.1 0.6
Allergy 1.9 4.5 9.0 3.0 0.7 -0.2 -0.5 -0.0 2.7 -3.0 3.0 -2.4 -2.1
Pain all over the body in last month 1.3 1.4 4.5 1.3 0.6 -1.5 -0.6 0.3 -0.7 -0.4 0.3 -1.9 -2.1
Diabetes (self-reported) 2.1 3.2 12.5 3.5 0.9 -0.6 -0.5 0.8 2.2 -2.1 2.0 -1.1 -1.7
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 7.5 -1.5 1.0 -0.1 -0.8 1.0 -1.2 2.0 -2.7 0.7 0.6
Medication: Ramipril 0.5 0.6 1.8 0.8 -1.3 0.2 1.0 -1.3 0.1 -0.2 -0.9 -0.4 0.1
Medication: Simvastatin 1.2 1.8 3.9 1.8 1.6 -1.5 -1.2 1.7 0.7 0.2 -0.4 -1.0 -2.0
Fluid intelligence score 1.2 2.4 3.3 -1.1 -1.8 1.8 1.5 -1.2 1.8 -1.2 1.5 1.7 1.8
Illnesses of siblings 0.7 1.0 2.7 -1.6 -0.6 0.6 1.2 -1.0 -0.6 0.9 -0.2 0.8 1.5
Neuroticism score 0.5 1.0 3.9 -0.0 0.0 -1.1 -0.8 0.2 -2.0 0.8 -1.5 0.1 -1.2
Weight 0.5 2.6 9.2 0.1 0.1 -2.5 -0.1 0.0 -1.0 -0.8 0.4 -3.0 -3.0
Impedance of arm (right) 0.7 3.4 8.9 0.9 -2.1 1.6 3.0 -3.0 2.0 -0.8 -0.6 0.6 1.7
Arm fat percentage (right) 0.3 1.3 4.1 0.8 -0.6 -1.5 0.6 -0.6 0.2 -1.1 0.2 -2.0 -1.9
Trunk fat-free mass 0.5 3.1 9.3 -1.0 0.5 -2.6 -0.8 0.7 -1.5 -0.7 1.3 -2.9 -3.0
Hip circumference 0.5 2.3 7.8 1.3 0.2 -1.7 0.7 -0.6 0.5 -1.6 0.3 -2.8 -2.6
Time employed in main current job 2.2 2.6 7.5 -2.7 -1.5 -0.5 0.2 -0.4 -2.3 2.2 -2.3 0.4 0.4
Alcohol intake versus 10 years previously 0.1 0.2 0.5 0.2 0.3 -0.6 -0.5 -0.1 0.7 -0.1 0.3 -0.7 -0.4
Father’s age at death 1.7 2.3 4.7 -0.1 0.7 2.0 -1.4 1.5 1.0 -0.9 2.1 2.2 1.9
Worrier / anxious feelings 2.0 3.9 8.0 -0.6 1.5 0.4 -2.8 2.4 -2.2 2.3 -2.4 2.4 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 5.4 2.3 0.6 -1.6 -0.9 0.6 0.1 -0.9 0.3 -1.4 -2.2
Falls in the last year 0.2 0.2 0.6 -0.0 -0.2 0.4 0.7 -0.8 0.2 -0.3 -0.6 0.3 0.4
Hair/balding pattern: Pattern 3 1.5 2.3 6.9 2.0 2.6 0.5 -1.7 2.4 1.7 -0.4 0.2 0.1 0.0
Number of live births 1.0 1.4 3.5 -1.2 0.4 -1.3 -1.1 0.8 -1.3 1.9 -1.1 -1.3 -0.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 5.9 -0.8 0.9 -2.0 -1.2 0.8 -1.4 0.0 -1.2 -2.4 -2.3
Pulse rate 2.1 3.5 7.7 0.8 2.7 -2.5 -1.8 1.6 -0.3 0.3 -0.4 -2.6 -2.8
Happiness 0.4 0.5 2.9 1.7 0.8 0.4 -0.8 0.3 0.1 0.0 0.7 0.2 0.5
Noisy workplace 2.7 3.3 6.2 0.3 2.1 -2.5 -2.1 2.0 -0.8 1.9 -1.3 -1.5 -2.5
Qualifications: A levels/AS levels or equivalent 2.6 5.8 16.2 -0.3 0.6 3.6 -1.4 1.6 2.7 -2.2 2.2 4.0 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.7 -1.1 0.4 -0.2 -0.6 0.7 -1.6 0.5 -1.0 0.3 0.1
Mouth/teeth dental problems: Dentures 0.5 0.9 3.3 -1.8 -0.7 -0.6 -0.3 0.1 -1.2 1.6 -0.4 -0.4 0.3
Asthma 1.2 2.3 6.9 -2.6 0.1 -1.1 0.2 -0.3 -2.2 1.8 -2.6 -0.4 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.2 -1.0 1.1 -0.1 -0.6 0.8 -0.8 0.6 -0.9 -0.7 -0.3
Medication: Cholesterol lowering 0.6 0.9 2.4 0.7 1.3 -1.2 -0.7 1.0 0.7 0.1 0.0 -0.6 -1.6
Depression (self-reported) 0.6 0.8 3.0 -0.4 -0.2 0.2 -0.3 0.0 -1.7 0.7 -1.7 0.8 0.3
Medication: Lansoprazole 1.7 1.9 6.9 0.9 1.4 -2.1 -0.9 1.1 0.6 0.2 -0.7 -1.6 -2.6
Prospective memory result 0.8 1.0 2.9 1.1 0.8 -0.3 -1.7 1.4 -0.9 -0.1 -0.7 -0.4 -1.0
Lung cancer (father) 1.3 1.5 4.0 0.9 -0.7 1.4 0.7 -0.8 0.7 0.5 -1.8 1.6 2.0
Illnesses of mother 0.4 0.6 1.7 -1.3 0.9 -0.5 -1.1 0.8 -0.4 0.8 0.1 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 6.5 -0.9 1.0 -2.2 -1.3 1.0 -1.5 0.1 -1.2 -2.5 -2.6
Pulse wave Arterial Stiffness index 1.1 1.3 3.5 -1.4 -1.0 -1.2 0.8 -0.6 -1.5 1.0 -0.2 -1.9 -1.0
Impedance of arm (left) 0.9 3.9 7.9 1.8 -1.6 2.3 2.5 -2.5 2.8 -1.0 -0.2 1.5 2.1
Arm fat mass (right) 0.6 2.3 8.6 0.5 -0.5 -2.3 0.5 -0.5 -0.5 -0.8 0.3 -2.9 -2.7
Trunk predicted mass 0.5 3.0 8.9 -0.9 0.4 -2.5 -0.7 0.6 -1.5 -0.7 1.3 -2.9 -3.0
Standing height 0.3 2.6 10.0 -0.4 -0.4 -2.0 1.0 -1.1 -0.2 -1.1 0.9 -3.2 -2.7
Length of working week for main job 2.0 2.2 6.4 1.5 -0.7 1.3 -0.2 0.3 2.2 -2.5 2.0 1.1 0.8
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.1 0.8 -0.4 -0.3 0.4 -0.4 -0.5 -0.0 -0.7 -0.7
Breastfed as a baby 1.4 1.7 4.1 -1.2 0.6 -1.6 0.1 -0.4 -1.4 2.0 -1.6 -1.6 -1.3
Tense / ‘highly strung’ 0.8 1.3 4.2 0.5 -1.0 -1.1 0.0 -0.7 -2.1 1.2 -2.0 -0.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 6.0 -0.8 -1.2 -0.5 -0.1 -0.1 -2.2 1.0 -2.5 1.0 0.0
Hair/balding pattern: Pattern 4 1.8 4.3 13.8 3.7 -1.7 0.8 2.5 -2.2 2.4 -2.2 1.5 -1.3 0.3
Birth weight of first child 0.6 1.0 2.0 -1.0 -1.2 -1.0 1.0 -1.4 -0.0 1.4 -0.8 -1.2 -0.2
Peak expiratory flow (PEF) 2.2 5.0 11.5 -0.3 2.9 -2.1 -3.4 3.3 -0.3 -0.3 0.4 -2.7 -2.7
Pulse wave reflection index 0.6 0.7 2.3 -0.9 -1.5 -0.6 1.0 -0.6 -1.1 0.5 -0.0 -0.6 -0.7
Ever highly irritable/argumentative for 2 days 0.8 0.9 3.0 0.9 -1.7 -0.1 1.6 -1.5 -0.5 0.0 -0.1 -0.5 0.3
Loud music exposure frequency 1.8 2.0 5.3 0.9 0.6 -2.3 0.6 -0.5 -1.1 0.9 -1.8 -1.9 -2.1
Qualifications: O levels/GCSEs or equivalent 3.5 5.6 21.2 1.8 0.4 3.4 -0.7 1.1 2.4 -1.5 0.5 4.6 3.1
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.3 0.7 -0.2 -1.6 -0.3 -0.1 -1.2 -0.2 -1.5 -1.6 -1.8
Blood clot in the leg (DVT) 0.4 0.5 1.5 0.7 0.3 -0.1 -1.1 0.7 0.5 0.6 1.0 1.2 -0.0
Medication: Paracetamol 3.1 5.1 8.5 -2.3 1.7 -2.9 -2.0 1.7 -2.5 2.1 -2.8 -1.7 -2.5
Headache pain in last month 1.3 2.2 10.2 -1.5 0.1 -1.1 -0.0 -0.1 -2.0 1.7 -3.2 -0.6 -0.7
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 6.1 -1.7 -1.3 1.5 1.3 -1.5 -0.3 0.5 0.5 1.0 2.5
Glaucoma (self-reported) 4.5 5.3 16.5 1.0 1.1 -4.1 -1.1 1.5 -1.1 1.2 0.5 -3.4 -4.0
Gout (self-reported) 2.1 2.8 9.6 1.9 0.9 -2.2 -0.5 0.1 1.0 -1.1 0.9 -2.5 -3.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.9 -1.5 -0.8 -0.3 0.2 -0.3 -1.0 1.7 -0.5 -0.3 1.1
Medication: Amlodipine 0.8 1.1 4.9 2.2 0.8 -0.7 -1.0 1.1 0.3 -0.3 0.3 -0.4 -1.4
Medication: Ventolin 100micrograms inhaler 2.8 3.5 13.9 -3.7 -0.9 -0.8 0.3 -0.8 -2.7 2.8 -2.1 0.0 0.5
Birth weight 0.9 1.9 13.9 -3.7 0.1 0.0 -0.7 0.8 -1.4 0.3 -0.3 0.8 0.8
Chronic bronchitis/emphysema (mother) 0.4 0.5 3.3 -0.4 0.0 -0.7 -0.1 0.2 -0.8 0.6 -1.8 -0.3 -0.6
High blood pressure (siblings) 1.4 2.0 5.0 0.5 -0.8 -2.0 0.4 -0.5 -1.8 0.3 -1.5 -2.1 -2.2
Forced vital capacity (FVC), Best measure 1.1 4.2 11.4 -1.6 0.1 -3.0 -0.4 -0.1 -2.2 1.0 -2.1 -3.4 -2.9
Body fat percentage 0.5 2.0 6.8 0.9 -0.7 -1.9 1.0 -1.0 -0.3 -0.7 -0.3 -2.6 -2.3
Leg fat percentage (right) 0.7 2.7 9.7 0.4 0.2 -2.6 0.1 -0.3 -1.2 -0.3 -0.5 -3.1 -2.9
Arm fat-free mass (right) 0.6 3.1 9.0 -0.5 0.4 -2.7 -0.7 0.7 -1.9 -0.2 0.8 -3.0 -2.9
Exposure to tobacco smoke outside home 0.8 1.1 3.3 -0.9 0.5 -1.3 -1.0 0.7 -1.4 0.3 -0.4 -1.8 -1.0
Comparative body size at age 10 0.3 0.9 3.9 0.0 0.7 -0.2 -1.9 2.0 -0.3 -0.3 -0.4 0.2 -0.3
Number of full brothers 1.0 1.3 4.6 2.1 0.6 -0.5 -0.4 0.3 1.2 -1.1 1.8 -0.8 -1.0
Worry too long after embarrassment 0.7 1.2 3.4 0.6 -0.1 -1.0 -0.2 -0.1 -1.6 1.8 -1.8 0.1 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.0 -1.2 -0.2 1.3 -1.0 0.4 0.1 -0.5 -0.0 1.4 1.1
Wheeze or whistling in the chest in last year 2.1 3.7 10.1 -2.0 -0.4 -2.0 0.3 -0.3 -3.2 2.8 -3.1 -1.0 -0.5
Number of children fathered 2.8 3.1 11.4 1.0 1.9 -2.2 -1.9 1.8 -0.3 -0.9 -0.1 -1.5 -3.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 3.1 0.3 -0.7 1.0 0.5 -0.6 0.3 0.7 -0.4 0.8 1.8
Age at first live birth 2.0 3.6 8.7 0.2 -0.3 2.8 0.3 0.1 2.3 -2.9 2.4 2.4 1.6
Pulse wave peak to peak time 1.1 1.2 3.6 1.2 0.8 1.3 -0.6 0.3 1.5 -1.1 0.3 1.9 1.1
Health satisfaction 0.6 0.8 1.6 1.1 1.3 -1.0 -0.4 -0.1 -0.8 0.5 -0.8 -0.9 -1.1
Shortness of breath walking on level ground 0.4 0.5 1.3 -0.8 -0.3 -0.7 -0.7 0.6 -1.1 0.3 -0.8 -0.7 -0.4
Qualifications: College or University degree 0.8 2.4 5.7 -1.7 0.2 2.1 -1.2 1.6 0.4 -2.4 1.6 1.7 1.3
Eye problems/disorders: None of the above 2.1 2.4 6.6 -2.6 -1.4 0.8 1.2 -1.2 -1.2 1.8 -1.5 0.8 2.2
Mouth/teeth dental problems: Loose teeth 1.4 1.6 4.8 0.7 -2.2 1.0 1.6 -1.6 -0.0 -1.9 0.4 -0.4 1.0
Emphysema/chronic bronchitis 1.7 2.0 5.2 -0.9 1.0 -2.3 -0.5 0.6 -1.5 2.2 -1.1 -0.7 -1.9
Medication for pain relief, constipation, heartburn 2.4 4.1 8.5 1.2 -1.6 2.9 1.2 -1.2 2.2 -1.9 2.0 2.4 2.7
Neck or shoulder pain in last month 1.3 1.9 3.3 -1.3 -0.5 -1.8 0.8 -0.9 -1.8 0.7 -1.7 -1.5 -1.8
Medication: Blood pressure 0.7 1.2 3.5 1.9 0.8 -0.7 -1.1 1.1 0.2 -0.6 -0.9 -0.4 -1.8
Angina (self-reported) 1.9 2.5 4.5 -0.6 -1.7 -1.5 2.1 -2.1 -1.7 1.3 -1.7 -1.7 -0.9
Migraine (self-reported) 1.8 2.3 6.1 -0.6 -0.1 -2.5 0.5 -0.1 -1.4 1.7 -1.8 -2.0 -2.0
Medication: Ibuprofen 0.6 0.7 1.5 -0.9 0.8 -0.4 -0.9 1.2 -0.9 0.9 -0.8 -0.5 -0.7
Medication: Allopurinol 3.0 4.0 9.9 2.7 1.6 -2.4 -1.0 0.8 1.2 -1.0 1.3 -3.0 -3.1
Medication: Omeprazole 0.3 0.4 0.9 0.6 0.8 -0.5 -0.7 0.6 0.3 1.0 -0.5 -0.5 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 2.0 -1.0 0.8 -0.5 -1.4 1.4 0.3 -0.6 0.2 -0.7 -0.8
Mean time to correctly identify matches 1.0 1.9 4.7 -1.6 -0.8 1.4 0.8 -1.0 -0.9 1.4 -0.4 2.1 2.2
Heart disease (mother) 0.5 0.6 1.9 1.0 -1.4 0.2 0.2 -0.0 0.9 -0.9 1.0 -0.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.0 1.4 -1.4 -0.2 1.1 -1.0 -0.3 0.7 -0.2 -0.6 -0.2
Whole body fat mass 0.6 2.6 9.4 0.5 -0.2 -2.4 0.6 -0.6 -0.8 -0.7 -0.2 -3.1 -2.9
Leg fat mass (right) 1.0 3.8 12.9 0.5 0.0 -3.1 0.2 -0.2 -1.4 -0.3 -0.1 -3.6 -3.5
Arm predicted mass (right) 0.6 3.1 9.5 -0.4 0.6 -2.7 -0.7 0.7 -1.6 -0.3 1.0 -3.0 -3.1
Pulse rate, automated reading 0.8 2.5 8.0 1.0 2.6 0.1 -2.8 2.5 1.1 -0.7 0.7 0.4 -0.6
Alcohol intake frequency. 0.4 0.8 2.3 -0.7 0.8 -1.3 -0.5 0.7 -0.9 0.7 0.1 -1.5 -1.2
Comparative height size at age 10 0.4 2.4 8.4 0.1 0.4 -2.4 0.5 -0.4 -0.8 0.1 -0.2 -2.9 -2.9
Number of full sisters 0.9 1.1 2.4 1.1 0.8 -1.5 0.0 0.2 0.0 1.2 -1.2 -1.5 -1.2
Suffer from ‘nerves’ 0.4 0.7 2.3 -0.5 -1.3 0.2 0.3 -1.0 -0.9 0.4 -1.5 0.7 -0.1
Overall health rating 1.7 3.6 7.8 1.5 2.3 -2.0 -2.8 2.3 -0.7 -0.4 -0.1 -1.9 -2.7
Chest pain or discomfort 0.4 0.5 1.3 -0.6 1.1 -0.1 -1.2 1.0 -0.8 0.8 -0.3 0.1 -0.2
Had major operations 2.1 2.5 6.0 0.5 1.6 1.2 -2.3 2.4 1.3 -1.2 2.0 0.9 1.1
Age at last live birth 1.7 2.4 4.9 0.3 0.3 2.2 -0.7 0.7 2.1 -2.2 2.1 1.7 1.3
Family relationship satisfaction 1.1 1.4 2.5 1.4 -1.6 -1.2 1.3 -1.4 -1.0 0.7 -0.2 -1.5 -0.2
Leg pain on walking 0.8 0.9 2.5 -1.4 -1.6 -0.6 1.1 -1.1 -0.8 0.0 0.4 -1.1 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.4 1.5 0.6 -0.9 0.9 -0.7 1.3 0.6 0.5 -0.7 -1.0
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.6 -0.3 -0.3 -1.2 -0.3 0.1 -1.3 0.1 -0.8 -0.3 -1.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 6.4 -0.2 -1.3 0.8 2.5 -2.4 1.0 0.0 -0.0 0.7 1.2
Medication: Aspirin 0.2 0.3 1.1 0.4 0.2 -0.8 -0.1 0.2 -0.3 -0.2 0.3 -0.9 -1.0
Supplements: Vitamin C 1.1 1.3 4.1 -0.5 -2.0 1.2 1.0 -1.1 0.6 -0.0 1.0 0.7 1.7
Knee pain experienced in last month 1.0 1.5 3.7 -1.0 1.6 -1.0 -1.8 1.9 0.2 -0.8 -0.9 -0.6 -1.2
Hypertension (Self-reported) 1.9 5.3 20.3 4.5 1.3 -2.2 -2.0 1.9 0.4 -1.3 -0.2 -2.2 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.8 0.4 0.4 0.5 -0.3 0.5 0.1 0.4 -1.3 0.9 0.3
Illnesses of father: Heart disease 0.8 1.1 3.7 -0.0 0.0 1.0 -1.0 1.3 1.1 -1.9 1.4 0.7 0.4
Illnesses of siblings: Diabetes 0.6 0.8 2.2 0.3 1.5 -0.5 -1.3 1.4 0.5 -0.0 0.2 -0.3 -1.2
Smoking status: Previous 2.1 3.2 8.1 0.1 -1.5 -1.6 2.7 -2.9 -0.8 0.2 -1.0 -2.6 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 6.0 -1.1 -2.5 -1.8 1.9 -2.3 -1.5 1.1 -0.5 -1.7 -1.2
Whole body fat-free mass 0.5 2.7 8.4 -0.4 0.2 -2.4 -0.6 0.6 -1.4 -0.9 1.3 -2.8 -2.9
Leg fat-free mass (right) 0.3 1.7 5.3 0.3 0.1 -1.6 -0.4 0.6 -0.6 -1.3 1.4 -2.0 -2.3
Arm fat percentage (left) 0.2 0.8 2.1 1.1 -0.4 -0.9 0.5 -0.5 0.5 -1.1 0.3 -1.4 -1.5
Average weekly red wine intake 0.6 0.9 2.4 -0.6 -1.2 1.2 -0.1 -0.0 0.4 -0.6 1.1 1.6 1.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.3 -1.0 -1.5 -0.1 -0.2 -0.6 -0.8 -0.2 0.4 -1.2 -0.0
Mood swings 0.9 1.6 4.5 -0.4 0.8 -2.1 -0.9 0.5 -1.8 0.9 -0.6 -0.9 -2.1
Loneliness, isolation 1.2 1.7 5.3 0.2 -1.2 -1.9 0.4 -0.7 -1.5 0.2 -0.1 -2.3 -1.9
Long-standing illness, disability or infirmity 1.5 2.3 6.0 0.0 0.1 -2.4 -0.6 0.5 -1.9 0.9 -1.0 -2.5 -2.3
Ever had bowel cancer screening 0.9 1.0 2.2 0.8 0.4 1.5 0.7 -0.4 1.4 -1.2 1.1 1.1 0.9
Diabetes diagnosed by doctor 1.4 2.3 7.9 2.8 0.6 -0.7 -0.3 0.6 1.6 -1.9 2.0 -1.3 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.4 0.3 -0.1 -1.2 -0.1 -0.1 0.2 -0.1 -0.5 -0.6 -1.2
Friendships satisfaction 0.3 0.3 0.7 0.7 -0.6 0.4 0.6 -0.8 -0.3 -0.6 -0.2 -0.1 0.8
Qualifications: nursing, teaching 0.5 0.8 3.0 -0.7 0.6 1.1 -0.5 1.4 -0.1 -0.6 -0.5 1.7 0.6
Commuting to job workplace: Walk 0.8 0.9 2.4 -1.6 0.6 1.4 -0.3 0.1 -0.2 -0.1 -0.6 1.2 1.4
Eye problems/disorders: Cataract 0.5 0.6 3.5 0.6 0.9 -0.1 -0.2 0.4 0.3 -1.9 0.3 -0.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 4.7 0.0 -0.2 1.9 -0.8 0.3 0.8 -0.3 -0.1 1.9 2.2
Medication for cholesterol 0.8 1.2 5.1 -2.3 -0.8 1.0 1.1 -1.1 0.2 0.3 0.4 0.9 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.0 -1.0 -0.4 -0.1 0.7 -0.2 -0.4 -0.8 0.1 -0.1 -0.4
Back pain experienced in last month 0.2 0.2 0.7 0.6 -0.9 0.2 0.1 -0.3 0.4 -0.2 0.8 -0.0 0.5
Mineral and other dietary supplements 0.3 0.4 1.7 0.2 0.3 0.9 0.2 -0.7 0.3 -1.3 -0.4 0.3 0.3
Breast cancer (self-reported) 2.2 2.7 5.4 -1.3 2.2 -0.9 -1.5 2.0 -1.4 2.0 -2.3 -0.4 -1.2
Asthma (self-reported) 0.9 1.7 6.0 -2.1 -0.1 -0.9 0.3 -0.4 -1.7 1.5 -2.5 -0.4 -0.1
Osteoporosis (self-reported) 0.2 0.2 0.7 -0.0 0.4 -0.8 -0.1 0.0 -0.7 0.6 -0.2 -0.1 -0.6
Osteoarthritis (self-reported) 0.8 1.1 2.9 -0.7 1.5 0.1 -1.4 1.7 0.2 -0.6 -1.4 0.3 -0.7
Medication: Aspirin 0.3 0.4 1.3 0.7 0.5 -0.8 -0.3 0.5 -0.1 -0.4 0.3 -0.7 -1.2
Medication: Gliclazide 1.0 1.1 2.6 1.6 0.6 -0.2 0.1 0.1 1.6 -1.4 1.5 -0.2 -1.0
Illnesses of father: None of the above (group 1) 2.3 2.8 11.5 -1.2 1.1 -2.1 0.2 -0.6 -1.6 3.4 -2.2 -1.2 -0.9
Smoking status: Current 1.4 2.2 8.3 2.0 -0.1 -2.2 -0.3 0.3 0.3 -0.5 1.2 -2.9 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 3.8 -0.9 1.5 -1.3 -0.9 0.9 -1.1 1.0 -1.9 -1.6 -1.1
Whole body water mass 0.5 2.9 9.5 -0.4 0.3 -2.5 -0.7 0.6 -1.3 -1.0 1.3 -2.9 -3.1
Leg predicted mass (right) 0.3 1.7 5.2 0.4 0.0 -1.6 -0.4 0.6 -0.6 -1.3 1.3 -2.0 -2.3
Arm fat mass (left) 0.4 1.5 5.7 0.5 -0.1 -1.8 0.2 -0.2 -0.4 -0.9 0.3 -2.4 -2.2
Number of self-reported non-cancer illnesses 2.1 3.7 11.0 1.5 0.4 -3.3 -1.2 1.0 -1.3 1.2 -1.0 -2.6 -3.2
Average weekly champagne plus white wine intake 0.4 0.5 1.4 0.2 0.8 0.7 0.7 -0.2 1.0 -0.2 -0.8 1.2 0.2
Miserableness 1.0 1.8 4.0 -0.2 0.6 -2.0 -1.1 0.8 -2.0 0.2 -1.3 -1.4 -1.9
Guilty feelings 2.3 3.5 11.1 -1.2 -1.2 -2.3 0.5 -0.8 -3.3 2.4 -2.2 -1.3 -1.5
Wears glasses or contact lenses 0.4 0.4 1.9 0.2 -0.3 -1.0 0.1 -0.1 0.3 0.3 0.8 -1.4 -0.7
Ever taken oral contraceptive pill 0.5 0.5 2.0 -0.2 0.4 0.5 -0.9 0.8 1.4 0.2 0.6 0.9 0.6
Hearing aid user 0.8 0.9 2.2 -0.7 0.5 1.5 -1.1 0.9 -0.1 -0.9 0.3 0.9 1.4
Mother’s age at death 0.9 1.1 4.5 -1.3 0.4 1.2 -0.6 0.9 -0.2 0.4 -0.2 2.1 1.4
Financial situation satisfaction 0.5 0.6 2.5 1.6 0.4 -0.6 -0.4 0.2 -0.4 -0.8 0.1 -0.7 -1.1
Tinnitus: Yes, now most or all of the time 1.4 1.7 6.3 0.1 1.9 -0.4 -2.5 2.3 0.5 0.1 0.2 0.0 -0.8
Commuting to job workplace: Public transport 1.4 1.6 3.5 -0.1 0.1 1.8 -1.0 0.9 1.6 -1.0 1.9 1.0 1.8
Eye problems/disorders: Glaucoma 5.4 6.4 20.8 0.3 1.0 -4.5 -1.0 1.2 -1.8 1.4 0.0 -3.8 -4.6
Medication: Blood pressure 1.2 2.3 10.9 3.3 1.2 -1.3 -1.4 1.4 0.5 -0.4 -0.1 -1.3 -1.6
Pain type(s) experienced in last month: Hip pain 1.2 1.5 5.3 0.1 0.6 -1.7 -1.0 0.3 -0.5 -0.3 0.0 -2.3 -2.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.6 0.3 -0.6 -0.4 0.8 -0.2 0.3 0.6 0.5 -0.8 0.1
High cholesterol (Self-reported) 0.7 1.2 4.0 0.5 0.7 -2.0 0.1 0.1 -0.1 0.5 0.5 -1.9 -1.9
Medication: Bendroflumethiazide 1.9 2.9 8.5 2.9 1.8 -1.1 -2.7 2.2 0.5 -0.2 0.8 -0.9 -1.5
Medication: Paracetamol 3.2 4.9 9.5 -1.2 2.4 -3.1 -2.5 2.4 -1.5 1.5 -1.8 -1.9 -2.9
Medication: Lisinopril 1.1 1.4 4.4 2.1 0.2 0.5 -1.2 1.6 1.6 -1.4 0.8 0.4 -0.1
Medication: Atorvastatin 1.5 1.8 4.7 -2.1 0.2 -1.6 -0.6 0.2 -2.2 1.7 -0.7 -1.5 -0.7
Illnesses of father: High blood pressure 0.9 1.2 3.0 1.3 0.8 0.3 -1.6 1.7 0.3 -1.7 0.7 0.1 -0.3
Alcohol drinker status: Never 0.4 0.5 2.5 -1.6 -0.2 -0.1 0.0 0.1 -1.3 0.7 0.2 -0.3 -0.4
Ever smoked 1.2 2.2 6.2 0.9 -1.4 -2.0 1.3 -1.6 -1.1 0.6 -0.7 -2.5 -1.4
Basal metabolic rate 0.6 3.1 10.2 -0.3 0.1 -2.7 -0.4 0.3 -1.4 -0.9 1.0 -3.1 -3.2
Leg fat percentage (left) 0.7 2.5 7.8 -0.0 -0.0 -2.5 -0.0 -0.2 -1.6 0.3 -1.0 -2.8 -2.6
Arm fat-free mass (left) 0.8 4.0 12.2 -1.3 0.1 -3.2 -0.4 0.2 -2.2 0.2 0.4 -3.5 -3.3
Number of operations (self-reported) 0.8 1.1 4.4 -0.3 1.4 0.3 -2.1 2.0 0.2 -0.5 0.6 0.3 0.2
Average weekly beer plus cider intake 0.8 1.2 3.4 1.4 -0.7 -0.4 1.8 -1.9 -0.1 1.4 -0.7 -0.2 0.2
Irritability 1.7 2.8 9.6 -0.6 -3.1 1.3 1.9 -2.4 -0.5 -1.8 1.0 1.2 1.1
Risk taking 0.5 0.8 2.7 -0.0 -1.1 -0.8 0.2 -0.6 0.6 -0.5 1.5 -1.6 -0.0
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.2 -2.1 1.0 -1.5 -0.9 0.9 -0.8 0.2 -0.2 -0.3 -2.0
Fractured/broken bones in last 5 years 2.5 3.2 10.4 -1.1 0.5 -1.3 -0.2 0.5 -2.9 3.2 -3.1 -0.2 -0.3
Age started oral contraceptive pill 1.0 1.2 2.7 -0.7 1.7 1.1 -1.3 1.6 0.7 0.5 0.0 1.3 1.1
Diastolic blood pressure, automated reading 0.4 1.3 5.0 0.4 0.2 -1.0 -0.5 0.3 -2.0 1.4 -2.2 0.1 -0.8
Ever depressed for a whole week 1.9 2.4 6.7 -1.1 -0.6 -1.8 0.9 -0.8 -2.0 2.6 -2.3 -1.1 -0.4
Unable to work because of sickness or disability 0.5 0.6 1.5 0.6 -0.9 -0.7 0.7 -1.2 -0.9 0.4 0.0 -1.1 -0.4
Commuting to job workplace: Cycle 0.7 0.8 2.5 -1.4 -0.2 0.6 0.9 -0.8 -0.5 0.7 -0.1 1.6 0.9
Myopia 0.7 1.1 4.3 0.3 1.6 -0.4 -1.7 2.1 -0.2 0.7 -0.4 -0.5 -0.2
Vascular/heart problems diagnosed by doctor 1.4 3.8 16.5 -4.1 -0.4 1.9 1.0 -0.9 -0.4 1.6 -0.1 2.1 3.0
Cholesterol lowering medication 2.0 2.9 8.9 0.4 0.7 -3.0 -0.9 0.8 -1.1 1.1 -0.4 -2.9 -2.7
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 0.8 1.0 -0.5 -0.6 0.8 0.4 0.7 -0.2 -0.4 -0.2
Pain experienced in last month 1.3 2.1 5.5 -0.5 -1.4 1.7 1.2 -0.9 0.2 0.8 1.7 2.1 2.3
Supplements: Calcium 0.8 0.9 2.1 -0.3 -0.0 -1.3 -0.9 1.4 -1.2 1.1 -0.2 -0.4 -1.1
Basal cell carcinoma (self-reported) 0.5 0.5 1.2 1.1 1.1 -0.4 -0.8 0.9 -0.1 0.5 -1.1 0.2 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 0.1 -1.0 0.2 1.0 -1.1 0.1 -0.7 -0.1 -0.3 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 2.1 0.2 0.4 0.0 -1.1 0.7 0.4 0.9 0.7 1.4 0.3
Heart disease (siblings) 1.3 1.6 3.2 1.6 1.5 -0.5 -1.8 1.4 1.3 -0.9 1.0 -1.0 -1.0
Alcohol drinker status: Previous 0.4 0.4 1.2 0.8 -0.2 0.1 1.1 -1.1 0.9 -0.3 0.5 -0.2 0.4
Pack years of smoking 0.5 0.8 2.3 1.5 -1.0 0.1 1.2 -1.4 0.4 -0.8 0.5 -0.4 0.2
Impedance of whole body 0.5 2.4 8.2 0.2 -1.7 0.9 2.7 -2.9 0.7 0.5 -1.6 0.3 1.2
Leg fat mass (left) 1.0 3.8 12.5 0.2 -0.0 -3.2 0.2 -0.2 -1.7 0.1 -0.5 -3.5 -3.5
Arm predicted mass (left) 0.8 3.9 11.6 -1.0 0.4 -3.1 -0.5 0.4 -2.1 -0.1 0.5 -3.4 -3.4