Hub : Genes

CHEK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1370	0.0470	5.3e-04	0.026	NA	0.031	NA	0.031	1.6e-02	NA	9.1e-03	NA	9.1e-03
2	GTEx	Cells Transformed fibroblasts	0.1490	0.0470	1.9e-04	0.160	NA	0.143	NA	0.152	5.0e-12	NA	7.8e-11	NA	1.7e-11
3	GTEx	Liver	0.2020	0.0860	4.8e-03	0.059	NA	0.043	NA	0.075	9.9e-03	NA	2.4e-02	NA	3.9e-03
4	GTEx	Nerve Tibial	0.1515	0.0543	3.3e-03	0.136	NA	0.125	NA	0.114	7.9e-10	NA	3.9e-09	NA	1.8e-08
5	GTEx	Testis	0.7210	0.0420	0.0e+00	0.644	NA	0.622	NA	0.639	1.5e-36	NA	1.5e-34	NA	4.4e-36
6	METSIM	Adipose	0.0519	0.0198	5.1e-05	0.040	0.039	0.037	0.040	0.033	1.2e-06	1.3e-06	2.3e-06	1.0e-06	9.2e-06
7	YFS	Blood	0.0244	0.0092	9.3e-06	0.023	0.012	0.017	0.012	0.018	4.3e-08	7.1e-05	2.1e-06	4.3e-05	1.3e-06
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0770	0.0450	4.8e-03	0.026	0.040	0.031	NA	0.028	1.3e-02	2.5e-03	6.6e-03	NA	9.6e-03
9	TCGA	Liver Hepatocellular Carcinoma	0.2380	0.0750	1.5e-09	0.219	0.223	0.241	NA	0.237	1.2e-10	7.8e-11	1.1e-11	NA	1.8e-11
10	TCGA	Thyroid Carcinoma	0.1090	0.0560	5.9e-03	0.031	0.014	0.016	NA	0.022	4.4e-04	1.4e-02	1.1e-02	NA	2.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.6	1.0	2.2	-0.1	1.0	1.5	-1.1	0.8	1.1	-1.2	-0.1	1.2	0.9
Bipolar Disorder or Schizophrenia	0.2	0.5	2.1	0.2	-0.4	-0.6	-0.1	-0.1	-0.4	-0.3	-1.5	-0.6	-1.1
Depressed Affect (Nagel 2018)	0.6	1.3	3.4	-0.0	1.2	-1.5	-1.6	0.9	-1.3	-0.1	-0.1	-1.0	-1.8
Depression (Nagel 2018)	0.6	0.9	4.7	0.5	-0.6	-0.9	-0.6	0.2	-2.2	0.2	-0.7	-1.2	-0.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	6.9	0.1	1.0	1.4	0.0	0.4	2.2	-2.6	1.9	0.6	0.3
Neuroticism (Nagel 2018)	0.5	1.1	5.0	-0.4	-0.3	-0.6	-0.8	-0.0	-2.2	0.9	-1.8	0.5	-0.7
Schizophrenia (2018)	1.0	2.0	4.8	0.3	-1.3	-2.0	0.7	-0.8	-1.4	0.5	-1.8	-1.7	-2.2
Schizophrenia vs Biploar Disorder	1.8	2.4	8.1	0.6	-1.0	-2.5	1.0	-0.5	-1.1	0.4	-0.0	-2.9	-2.4
Worry (Nagel 2018)	0.7	1.4	5.3	-0.6	-0.6	0.7	-0.5	-0.2	-1.7	1.0	-2.3	1.7	0.6
Alzheimer’s Disease (in mother)	1.5	1.8	3.7	-0.8	-1.5	0.3	1.6	-1.9	-1.1	1.9	-1.5	0.1	1.2
Alzheimer’s Disease (in father)	0.8	0.9	2.6	1.4	-0.6	-1.3	0.3	-0.3	-0.1	-0.0	0.2	-1.6	-1.5
Alzheimer’s Disease (including proxy)	0.9	1.3	3.4	-0.1	-1.3	-0.0	1.6	-1.8	-0.9	1.5	-0.9	-0.2	1.0
Crohns Disease (2017)	1.7	3.7	10.5	-2.4	3.1	-1.0	-2.6	3.2	-1.0	0.9	-0.7	0.1	-1.3
Irritable Bowel Disease (IBD)	1.3	3.0	9.6	-1.9	2.2	-1.0	-2.6	3.1	-1.1	0.8	-0.4	0.2	-1.6
Ulcerative Colitis (UC)	0.5	1.0	3.9	-0.1	0.7	-0.3	-1.9	2.0	-0.0	0.1	0.4	0.6	-1.1
Major Depression (MDD)	1.5	1.9	6.4	-1.1	0.1	0.8	0.1	0.5	-1.7	1.8	-2.5	1.5	1.3
Reaction Time	1.6	3.1	9.1	-2.2	-0.8	1.7	0.4	-1.0	-1.3	1.6	-0.8	3.0	2.8
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-0.0	-1.6	0.9	1.4	-1.3	1.3	-1.9	1.4	0.1	0.5
Breast Cancer	8.4	20.2	68.1	4.3	0.1	3.8	0.5	-0.4	7.7	-5.4	8.2	0.8	3.5
Ovarian Cancer	5.3	7.0	19.4	-3.8	1.5	-1.4	-0.7	0.7	-3.6	4.3	-4.4	0.4	-0.1
Prostate Cancer	3.1	4.4	13.6	-1.9	-0.3	-2.4	-0.7	0.3	-3.7	2.8	-2.6	-1.0	-2.2
Age at First Birth	2.2	3.2	10.7	1.0	0.5	3.3	0.3	-0.5	1.4	-2.0	0.9	2.7	2.5
Bipolar Disorder (2011)	0.5	0.5	1.6	0.7	1.3	0.2	-0.7	0.8	0.4	-0.7	0.6	0.3	-0.4
Body Mass Index (BMI) (2010)	0.6	0.8	2.3	-1.0	-0.7	-1.0	-0.0	0.0	-1.5	0.2	0.1	-1.5	-0.8
Coronary Artery Disease (CAD)	1.7	2.1	5.2	2.2	0.7	0.9	-1.0	0.9	2.3	-2.0	1.8	0.2	-0.5
Crohns Disease (2012)	0.5	0.8	3.0	-1.7	1.4	0.1	-0.6	1.2	-0.9	0.1	-0.3	0.8	-0.2
Mean Putamen Volume	1.4	1.6	5.8	-0.9	0.4	-2.4	-0.2	0.8	-0.6	1.0	-0.5	-2.2	-1.7
Fasting Glucose	1.5	1.8	5.3	1.1	-2.3	-0.5	1.8	-1.9	0.1	-0.7	-0.1	-1.9	-0.3
HbA1C	0.2	0.2	1.1	-0.2	0.1	0.1	-0.2	0.2	-1.1	0.2	-1.0	0.3	0.0
HDL Cholesterol	0.8	1.3	3.9	-0.6	-0.9	1.2	1.1	-1.1	-0.3	0.7	-2.0	0.7	1.8
LDL Cholesterol	0.1	0.2	0.9	0.2	-0.3	-0.9	-0.0	0.2	-0.2	0.1	0.3	-1.0	-0.5
Lupus	1.1	1.6	4.5	1.1	-0.7	-1.4	0.5	-0.2	0.4	-1.6	0.9	-2.1	-2.0
Neuroticism (2016)	1.8	2.6	5.7	-0.0	0.7	-2.4	-0.6	0.7	-2.1	2.2	-2.1	-1.3	-1.9
Primary Biliary Cirrhosis	0.9	1.2	3.9	2.0	0.9	-0.3	-1.1	0.9	0.7	-1.2	0.8	-1.4	-0.9
Rheumatoid Arthritis	1.3	1.9	5.3	0.7	0.1	1.4	-0.1	0.1	2.1	-2.3	1.6	1.7	0.7
Schizophrenia (2014)	1.2	2.7	6.4	0.9	-1.2	-2.3	0.5	-0.5	-1.6	0.5	-2.2	-2.2	-2.5
Triglycerides	0.4	0.6	2.0	-0.1	-0.9	-1.2	0.2	-0.5	-0.7	0.3	-0.1	-1.4	-0.9
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.3	0.9	-1.9	-2.1	1.9	-1.8	-1.1	1.5	-0.8	-2.0	-1.1
Ulcerative Colitis	0.6	0.9	3.5	-0.4	0.8	-0.4	-1.9	1.8	-0.6	0.6	0.0	0.8	-0.6
Blood Eosinophil Count	0.6	4.2	13.5	-2.9	0.5	-1.4	-0.6	0.9	-3.7	2.2	-3.2	-1.2	-0.6
Blood Platelet Count	1.3	15.2	26.8	-4.7	5.2	-2.6	-4.5	4.2	-3.3	4.4	-5.0	-0.7	-1.7
Blood Red Count	1.3	12.5	27.6	-5.2	3.5	2.2	-4.3	4.0	-2.0	2.6	-3.4	4.2	2.6
Blood White Count	0.4	3.0	7.9	-1.3	1.9	-0.4	-2.3	2.8	-0.6	-2.6	0.3	-0.8	-2.0
Heel T-Score	2.5	20.2	65.1	-8.1	-3.3	5.1	1.6	-1.7	2.0	-4.7	6.4	2.3	4.8
BMI	0.3	2.0	5.8	-0.3	-1.7	-1.8	1.0	-1.2	-1.6	0.1	0.3	-2.4	-1.8
Height	0.2	3.2	13.7	-0.2	-0.8	-1.7	1.1	-1.0	0.9	-1.8	1.0	-3.7	-2.7
Waist Hip Ratio (WHR)	3.6	16.1	55.8	-4.8	-0.1	-4.0	-2.7	2.4	-7.5	5.1	-4.1	-1.8	-2.5
Systolic Blood Pressure	0.7	3.6	7.1	1.9	1.0	-1.3	-2.6	2.4	-2.3	-0.4	-2.7	-0.3	-2.2
Smoking Status	2.6	6.1	25.3	1.5	-1.4	-3.6	1.7	-1.8	-0.5	-0.4	0.3	-5.0	-3.6
Allergy or Eczema	3.3	8.7	19.3	-4.3	1.3	-0.3	-2.0	2.1	-4.4	3.9	-4.2	2.1	1.4
Cardiovascular Disease	1.4	4.5	16.8	4.1	1.0	-1.9	-1.4	1.6	0.1	-2.0	1.0	-2.0	-3.3
Hypothyroidism (self reported)	0.6	1.4	5.8	-2.4	0.2	-0.6	-0.7	0.8	-1.1	2.1	-0.5	-0.1	0.9
Respiratory disease	0.8	1.7	6.2	-2.5	-0.3	-0.9	0.5	-0.7	-1.8	1.2	-2.2	-0.4	-0.2
Type 2 Diabetes (T2D) (2018)	1.8	3.4	12.9	3.6	0.1	-0.7	1.3	-0.7	1.6	-2.3	1.6	-1.9	-2.1
Lung FEV1/FVC ratio	0.9	4.8	8.4	0.9	1.9	2.9	-1.8	1.6	2.3	-2.7	2.7	2.5	1.8
Lung FVC	1.3	6.4	14.7	-1.9	0.6	-3.3	-1.1	0.6	-3.2	1.9	-3.1	-3.8	-2.9
Neuroticism	0.3	0.7	1.9	0.5	0.8	-0.3	-1.4	0.6	-1.2	0.4	-0.9	0.8	-0.5
Chronotype (morning person)	1.3	3.1	10.3	-2.4	0.4	-0.3	-0.8	0.1	-2.0	3.2	-2.8	1.1	0.7
Hair Pigment	0.1	3.7	15.0	-1.5	-0.5	-0.8	-1.2	1.1	-3.9	2.5	-3.1	0.1	0.2
Tanning	0.1	1.8	7.7	-2.2	0.0	-0.8	-0.3	-0.2	-1.6	2.8	-1.4	0.1	0.3
Hand grip strength (left)	0.4	0.9	3.9	0.7	-1.0	-0.6	0.5	-0.8	-0.1	-1.4	0.0	-2.0	-0.9
Number of treatments/medications taken	2.5	4.5	8.1	0.9	2.2	-2.8	-2.7	2.6	-1.3	2.0	-1.5	-1.7	-2.6
Average weekly spirits intake	0.6	0.7	2.5	-0.1	-1.6	0.4	0.7	-0.8	-1.3	0.6	-0.8	0.1	0.8
Sensitivity / hurt feelings	1.6	2.7	6.9	-0.3	0.3	-2.3	-0.5	0.3	-2.2	2.2	-2.6	-1.3	-1.8
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.7	-0.1	0.6	-1.7	-1.7	1.4	-2.4	1.2	-1.3	-1.1	-1.7
Hearing difficulty/problems: Yes	1.0	1.5	5.4	0.1	-0.6	-1.1	0.1	-0.3	-2.3	1.2	-2.3	-0.9	-0.7
Relative age of first facial hair	0.5	1.1	4.5	0.9	-0.9	-1.0	1.1	-0.7	-0.4	1.0	-2.1	-1.0	-0.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.6	2.1	-0.0	0.2	-0.1	0.1	1.0	-2.1	2.0	-1.1	-0.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.0	1.8	-1.1	1.3	2.1	-2.2	0.9	-1.0	0.5	-0.1	1.1
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	-0.0	0.1	0.5	0.0	0.1	-0.3	-0.4	-1.0	-0.1	0.4
Systolic blood pressure, automated reading	1.4	4.0	8.9	1.3	1.4	-2.4	-2.2	2.2	-2.2	0.7	-2.2	-1.5	-3.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	8.3	2.9	0.1	0.2	0.0	-0.1	0.9	-2.0	1.7	-0.6	-0.8
Angina	2.1	2.8	5.4	-0.6	-2.0	-1.2	2.3	-2.3	-1.8	1.2	-2.0	-1.6	-0.6
Medication for hormone replacement therapy	1.0	1.1	4.2	0.7	0.0	2.1	0.3	-0.1	-0.2	-1.2	-0.0	1.5	1.6
Vitamin and mineral supplements	0.3	0.4	1.4	-0.6	0.9	1.2	-0.3	0.1	0.4	-0.7	-0.6	0.6	0.7
Supplements: Zinc	0.5	0.5	1.5	-1.2	0.3	0.1	-0.8	1.2	-0.5	1.0	0.1	0.3	0.4
Medication: Co-codamol	1.4	1.6	3.8	0.7	1.2	-1.9	-0.9	1.1	-0.0	1.3	-0.5	-1.9	-1.7
Medication: Metformin	1.5	2.1	8.5	2.9	1.2	-0.3	-0.4	0.9	1.5	-2.1	1.5	-0.6	-1.1
Diabetes (father)	1.5	1.9	5.2	0.1	0.0	2.0	0.1	0.2	1.2	-2.3	1.5	2.2	1.0
Diabetes (mother)	1.0	1.2	3.8	0.9	0.3	1.4	-0.8	0.7	1.2	-1.3	1.1	2.0	0.4
Severe depression (siblings)	1.5	1.7	4.4	-1.5	-0.5	-1.3	0.3	0.1	-1.9	2.1	-1.4	-1.4	-0.7
Pack years adult smoking proportion	0.5	0.8	2.6	1.6	-1.1	-0.1	0.9	-1.2	0.2	-0.9	0.6	-0.6	-0.1
Impedance of leg (right)	0.4	2.0	5.6	-0.4	-1.0	-1.1	2.2	-2.4	-0.7	1.3	-1.8	-1.5	-0.5
Leg fat-free mass (left)	0.4	2.3	7.5	0.5	-0.0	-2.0	-0.1	0.3	-0.6	-1.4	1.3	-2.6	-2.7
Trunk fat percentage	0.5	2.0	5.8	0.9	-1.2	-1.5	1.6	-1.6	0.1	-1.0	-0.2	-2.4	-1.9
Hand grip strength (right)	0.3	0.9	2.5	0.8	-1.6	-0.7	1.2	-1.3	-0.5	-0.3	-0.9	-0.9	-0.7
Townsend deprivation index at recruitment	0.8	1.2	3.7	1.5	-0.3	-1.8	0.2	-0.1	-0.2	0.4	-0.7	-1.9	-1.3
Current tobacco smoking	1.3	2.2	7.7	2.2	-0.5	-2.1	-0.0	0.1	0.3	-0.5	1.2	-2.8	-1.7
Average weekly fortified wine intake	0.3	0.4	1.8	-0.6	-0.2	0.3	-0.5	0.2	-1.3	0.8	-0.2	-0.2	0.7
Maternal smoking around birth	1.6	2.4	6.8	2.6	-1.1	-1.5	0.9	-1.1	0.2	-1.2	-1.0	-2.3	-1.9
Fed-up feelings	0.5	0.9	2.6	0.5	0.7	-1.5	-1.1	0.9	-0.7	-0.1	0.4	-1.0	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.3	1.4	-0.8	-0.6	0.2	-0.4	-1.8	-0.1	-0.5	-0.6	-0.4
Relative age voice broke	0.5	0.7	2.4	1.5	0.9	-1.0	-0.4	0.4	0.8	0.5	-0.5	-0.7	-1.1
Taking other prescription medications	3.0	4.7	12.3	0.7	0.4	-3.5	-0.8	0.6	-2.2	2.4	-2.2	-3.1	-2.8
Age when periods started (menarche)	0.6	1.4	4.1	-1.4	0.6	2.0	-0.6	0.3	-0.2	-0.6	0.4	2.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.9	0.6	1.2	-0.5	-1.7	1.4	-1.1	-0.2	-1.1	-0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	15.1	-3.9	-1.6	2.7	0.6	-0.5	0.1	-2.0	1.9	1.9	2.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	0.4	0.9	-0.6	-0.8	0.9	-0.1	0.8	-0.9	0.1	-0.3
Qualifications: CSEs or equivalent	1.4	1.9	7.0	-1.1	-0.2	-1.2	0.2	-0.5	-2.2	2.6	-1.8	-0.6	-0.6
Serious illness, injury or assault to yourself	2.0	2.4	6.4	0.6	1.1	-2.3	-0.2	0.1	-1.0	1.5	-1.1	-2.4	-2.5
High blood pressure	2.0	5.7	22.2	4.7	1.3	-2.3	-1.9	1.8	0.5	-1.3	-0.0	-2.4	-3.6
Hayfever, allergic rhinitis or eczema	2.8	6.2	13.6	-3.7	-0.6	0.7	0.1	0.4	-3.3	3.2	-3.6	2.8	2.4
Multivitamins +/- minerals	0.5	0.7	1.9	0.6	0.3	-1.4	-0.7	0.8	-0.3	0.6	0.8	-1.0	-1.1
Stomach or abdominal pain in last month	1.0	1.3	3.2	-1.5	0.0	0.9	0.1	-0.2	-1.0	1.2	-1.8	1.4	1.5
Supplements: Glucosamine	0.4	0.6	1.7	0.5	0.4	-0.8	-0.6	0.6	1.3	0.4	1.1	-1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	1.2	0.4	0.6	-0.5	1.1	0.5	-1.4	0.8	0.6	-0.4
Medication: Atenolol	0.9	1.1	1.9	1.2	-0.9	-1.1	1.4	-1.1	-0.9	0.7	-0.9	-1.4	-0.7
Medication: Levothyroxine sodium	0.4	0.7	2.2	-1.0	-0.3	-0.5	0.2	-0.2	-0.9	1.5	-1.3	0.1	0.6
Sitting height	0.5	3.4	15.2	-3.9	0.0	-1.8	0.2	-0.2	-2.3	0.4	-0.5	-2.4	-2.0
Chronic bronchitis/emphysema (father)	0.6	0.6	1.7	-0.7	-0.8	1.3	0.3	-0.3	0.1	-0.2	0.3	1.3	1.3
High blood pressure (mother)	0.2	0.3	2.0	1.4	0.4	-0.3	0.3	0.1	0.1	-0.6	-0.2	-0.5	-0.5
Body mass index (BMI)	0.3	1.1	3.7	0.3	0.2	-1.7	-0.4	0.4	-1.0	-0.4	0.0	-1.8	-1.9
Impedance of leg (left)	0.5	2.4	6.4	-1.0	-1.1	-1.0	1.9	-2.2	-1.4	2.0	-2.5	-0.9	-0.1
Leg predicted mass (left)	0.4	2.3	7.5	0.5	0.0	-2.0	-0.1	0.3	-0.6	-1.5	1.4	-2.6	-2.7
Trunk fat mass	0.6	2.4	9.0	0.4	-0.7	-2.1	1.1	-1.1	-0.5	-1.0	-0.0	-3.0	-2.6
Waist circumference	1.1	4.1	9.2	-1.1	0.5	-3.0	-1.3	1.1	-2.9	1.2	-1.2	-2.7	-2.9
Number of incorrect matches in round	0.2	0.3	1.1	1.1	-0.0	-0.3	0.7	-0.3	0.4	0.5	0.6	0.1	-0.1
Past tobacco smoking	2.3	4.2	12.1	-0.5	1.4	2.7	-2.1	2.5	1.4	-0.9	1.3	3.5	2.3
Alcohol usually taken with meals	3.4	5.5	11.6	-0.3	0.8	3.3	-1.7	1.6	2.4	-3.4	3.3	2.6	1.9
Nervous feelings	0.8	1.5	6.4	0.8	0.9	-0.6	-1.3	1.3	-1.2	0.9	-2.5	0.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	0.9	0.1	-0.8	-0.9	0.2	-1.4	0.7	-1.0	-0.5	-0.9
Hearing difficulty/problems with background noise	0.9	1.4	5.2	1.6	0.2	-1.5	-0.4	0.2	-0.9	-0.0	-0.7	-2.3	-1.5
Hair/balding pattern: Pattern 2	0.9	1.1	3.9	0.6	-1.0	-0.2	0.7	-1.2	1.3	-1.4	2.0	-0.1	-0.6
Had menopause	1.5	1.9	4.5	0.7	-1.0	1.6	0.8	-0.9	2.0	-1.4	2.1	0.6	1.4
Had other major operations	0.9	1.1	2.2	-1.1	1.1	-0.6	-1.3	1.5	-1.5	1.3	-0.5	-0.4	-0.1
Forced vital capacity (FVC)	1.2	4.5	12.7	-1.4	0.1	-3.1	-0.3	-0.2	-2.3	1.0	-2.1	-3.6	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	18.0	-4.2	-1.7	2.5	1.3	-1.3	0.3	-2.7	2.2	1.3	2.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.7	-1.0	-0.0	-0.9	-0.3	0.4	-1.3	1.9	-1.0	-0.5	0.2
Qualifications: None of the above	0.6	1.3	2.6	0.2	0.3	-1.6	0.2	-0.6	-1.2	1.1	-1.6	-1.6	-1.4
Financial difficulties in last 2 years	0.9	1.3	3.2	0.0	1.0	-0.9	-1.5	1.7	-1.1	-0.8	-0.1	-0.8	-1.8
Mouth/teeth dental problems	0.7	1.0	3.4	0.6	1.8	0.5	-0.5	1.0	1.4	-0.8	1.3	0.4	-0.4
Heart attack	0.3	0.4	0.9	0.2	-0.9	0.4	1.0	-1.0	0.3	-0.9	0.3	-0.1	0.6
Allergy	1.9	4.5	9.0	3.0	0.7	-0.2	-0.5	-0.0	2.7	-3.0	3.0	-2.4	-2.1
Pain all over the body in last month	1.3	1.4	4.5	1.3	0.6	-1.5	-0.6	0.3	-0.7	-0.4	0.3	-1.9	-2.1
Diabetes (self-reported)	2.1	3.2	12.5	3.5	0.9	-0.6	-0.5	0.8	2.2	-2.1	2.0	-1.1	-1.7
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	7.5	-1.5	1.0	-0.1	-0.8	1.0	-1.2	2.0	-2.7	0.7	0.6
Medication: Ramipril	0.5	0.6	1.8	0.8	-1.3	0.2	1.0	-1.3	0.1	-0.2	-0.9	-0.4	0.1
Medication: Simvastatin	1.2	1.8	3.9	1.8	1.6	-1.5	-1.2	1.7	0.7	0.2	-0.4	-1.0	-2.0
Fluid intelligence score	1.2	2.4	3.3	-1.1	-1.8	1.8	1.5	-1.2	1.8	-1.2	1.5	1.7	1.8
Illnesses of siblings	0.7	1.0	2.7	-1.6	-0.6	0.6	1.2	-1.0	-0.6	0.9	-0.2	0.8	1.5
Neuroticism score	0.5	1.0	3.9	-0.0	0.0	-1.1	-0.8	0.2	-2.0	0.8	-1.5	0.1	-1.2
Weight	0.5	2.6	9.2	0.1	0.1	-2.5	-0.1	0.0	-1.0	-0.8	0.4	-3.0	-3.0
Impedance of arm (right)	0.7	3.4	8.9	0.9	-2.1	1.6	3.0	-3.0	2.0	-0.8	-0.6	0.6	1.7
Arm fat percentage (right)	0.3	1.3	4.1	0.8	-0.6	-1.5	0.6	-0.6	0.2	-1.1	0.2	-2.0	-1.9
Trunk fat-free mass	0.5	3.1	9.3	-1.0	0.5	-2.6	-0.8	0.7	-1.5	-0.7	1.3	-2.9	-3.0
Hip circumference	0.5	2.3	7.8	1.3	0.2	-1.7	0.7	-0.6	0.5	-1.6	0.3	-2.8	-2.6
Time employed in main current job	2.2	2.6	7.5	-2.7	-1.5	-0.5	0.2	-0.4	-2.3	2.2	-2.3	0.4	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	0.3	-0.6	-0.5	-0.1	0.7	-0.1	0.3	-0.7	-0.4
Father’s age at death	1.7	2.3	4.7	-0.1	0.7	2.0	-1.4	1.5	1.0	-0.9	2.1	2.2	1.9
Worrier / anxious feelings	2.0	3.9	8.0	-0.6	1.5	0.4	-2.8	2.4	-2.2	2.3	-2.4	2.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	5.4	2.3	0.6	-1.6	-0.9	0.6	0.1	-0.9	0.3	-1.4	-2.2
Falls in the last year	0.2	0.2	0.6	-0.0	-0.2	0.4	0.7	-0.8	0.2	-0.3	-0.6	0.3	0.4
Hair/balding pattern: Pattern 3	1.5	2.3	6.9	2.0	2.6	0.5	-1.7	2.4	1.7	-0.4	0.2	0.1	0.0
Number of live births	1.0	1.4	3.5	-1.2	0.4	-1.3	-1.1	0.8	-1.3	1.9	-1.1	-1.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	5.9	-0.8	0.9	-2.0	-1.2	0.8	-1.4	0.0	-1.2	-2.4	-2.3
Pulse rate	2.1	3.5	7.7	0.8	2.7	-2.5	-1.8	1.6	-0.3	0.3	-0.4	-2.6	-2.8
Happiness	0.4	0.5	2.9	1.7	0.8	0.4	-0.8	0.3	0.1	0.0	0.7	0.2	0.5
Noisy workplace	2.7	3.3	6.2	0.3	2.1	-2.5	-2.1	2.0	-0.8	1.9	-1.3	-1.5	-2.5
Qualifications: A levels/AS levels or equivalent	2.6	5.8	16.2	-0.3	0.6	3.6	-1.4	1.6	2.7	-2.2	2.2	4.0	2.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	2.7	-1.1	0.4	-0.2	-0.6	0.7	-1.6	0.5	-1.0	0.3	0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	3.3	-1.8	-0.7	-0.6	-0.3	0.1	-1.2	1.6	-0.4	-0.4	0.3
Asthma	1.2	2.3	6.9	-2.6	0.1	-1.1	0.2	-0.3	-2.2	1.8	-2.6	-0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	-1.0	1.1	-0.1	-0.6	0.8	-0.8	0.6	-0.9	-0.7	-0.3
Medication: Cholesterol lowering	0.6	0.9	2.4	0.7	1.3	-1.2	-0.7	1.0	0.7	0.1	0.0	-0.6	-1.6
Depression (self-reported)	0.6	0.8	3.0	-0.4	-0.2	0.2	-0.3	0.0	-1.7	0.7	-1.7	0.8	0.3
Medication: Lansoprazole	1.7	1.9	6.9	0.9	1.4	-2.1	-0.9	1.1	0.6	0.2	-0.7	-1.6	-2.6
Prospective memory result	0.8	1.0	2.9	1.1	0.8	-0.3	-1.7	1.4	-0.9	-0.1	-0.7	-0.4	-1.0
Lung cancer (father)	1.3	1.5	4.0	0.9	-0.7	1.4	0.7	-0.8	0.7	0.5	-1.8	1.6	2.0
Illnesses of mother	0.4	0.6	1.7	-1.3	0.9	-0.5	-1.1	0.8	-0.4	0.8	0.1	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.5	-0.9	1.0	-2.2	-1.3	1.0	-1.5	0.1	-1.2	-2.5	-2.6
Pulse wave Arterial Stiffness index	1.1	1.3	3.5	-1.4	-1.0	-1.2	0.8	-0.6	-1.5	1.0	-0.2	-1.9	-1.0
Impedance of arm (left)	0.9	3.9	7.9	1.8	-1.6	2.3	2.5	-2.5	2.8	-1.0	-0.2	1.5	2.1
Arm fat mass (right)	0.6	2.3	8.6	0.5	-0.5	-2.3	0.5	-0.5	-0.5	-0.8	0.3	-2.9	-2.7
Trunk predicted mass	0.5	3.0	8.9	-0.9	0.4	-2.5	-0.7	0.6	-1.5	-0.7	1.3	-2.9	-3.0
Standing height	0.3	2.6	10.0	-0.4	-0.4	-2.0	1.0	-1.1	-0.2	-1.1	0.9	-3.2	-2.7
Length of working week for main job	2.0	2.2	6.4	1.5	-0.7	1.3	-0.2	0.3	2.2	-2.5	2.0	1.1	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.1	0.8	-0.4	-0.3	0.4	-0.4	-0.5	-0.0	-0.7	-0.7
Breastfed as a baby	1.4	1.7	4.1	-1.2	0.6	-1.6	0.1	-0.4	-1.4	2.0	-1.6	-1.6	-1.3
Tense / ‘highly strung’	0.8	1.3	4.2	0.5	-1.0	-1.1	0.0	-0.7	-2.1	1.2	-2.0	-0.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	6.0	-0.8	-1.2	-0.5	-0.1	-0.1	-2.2	1.0	-2.5	1.0	0.0
Hair/balding pattern: Pattern 4	1.8	4.3	13.8	3.7	-1.7	0.8	2.5	-2.2	2.4	-2.2	1.5	-1.3	0.3
Birth weight of first child	0.6	1.0	2.0	-1.0	-1.2	-1.0	1.0	-1.4	-0.0	1.4	-0.8	-1.2	-0.2
Peak expiratory flow (PEF)	2.2	5.0	11.5	-0.3	2.9	-2.1	-3.4	3.3	-0.3	-0.3	0.4	-2.7	-2.7
Pulse wave reflection index	0.6	0.7	2.3	-0.9	-1.5	-0.6	1.0	-0.6	-1.1	0.5	-0.0	-0.6	-0.7
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.0	0.9	-1.7	-0.1	1.6	-1.5	-0.5	0.0	-0.1	-0.5	0.3
Loud music exposure frequency	1.8	2.0	5.3	0.9	0.6	-2.3	0.6	-0.5	-1.1	0.9	-1.8	-1.9	-2.1
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	21.2	1.8	0.4	3.4	-0.7	1.1	2.4	-1.5	0.5	4.6	3.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.3	0.7	-0.2	-1.6	-0.3	-0.1	-1.2	-0.2	-1.5	-1.6	-1.8
Blood clot in the leg (DVT)	0.4	0.5	1.5	0.7	0.3	-0.1	-1.1	0.7	0.5	0.6	1.0	1.2	-0.0
Medication: Paracetamol	3.1	5.1	8.5	-2.3	1.7	-2.9	-2.0	1.7	-2.5	2.1	-2.8	-1.7	-2.5
Headache pain in last month	1.3	2.2	10.2	-1.5	0.1	-1.1	-0.0	-0.1	-2.0	1.7	-3.2	-0.6	-0.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	6.1	-1.7	-1.3	1.5	1.3	-1.5	-0.3	0.5	0.5	1.0	2.5
Glaucoma (self-reported)	4.5	5.3	16.5	1.0	1.1	-4.1	-1.1	1.5	-1.1	1.2	0.5	-3.4	-4.0
Gout (self-reported)	2.1	2.8	9.6	1.9	0.9	-2.2	-0.5	0.1	1.0	-1.1	0.9	-2.5	-3.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.9	-1.5	-0.8	-0.3	0.2	-0.3	-1.0	1.7	-0.5	-0.3	1.1
Medication: Amlodipine	0.8	1.1	4.9	2.2	0.8	-0.7	-1.0	1.1	0.3	-0.3	0.3	-0.4	-1.4
Medication: Ventolin 100micrograms inhaler	2.8	3.5	13.9	-3.7	-0.9	-0.8	0.3	-0.8	-2.7	2.8	-2.1	0.0	0.5
Birth weight	0.9	1.9	13.9	-3.7	0.1	0.0	-0.7	0.8	-1.4	0.3	-0.3	0.8	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.3	-0.4	0.0	-0.7	-0.1	0.2	-0.8	0.6	-1.8	-0.3	-0.6
High blood pressure (siblings)	1.4	2.0	5.0	0.5	-0.8	-2.0	0.4	-0.5	-1.8	0.3	-1.5	-2.1	-2.2
Forced vital capacity (FVC), Best measure	1.1	4.2	11.4	-1.6	0.1	-3.0	-0.4	-0.1	-2.2	1.0	-2.1	-3.4	-2.9
Body fat percentage	0.5	2.0	6.8	0.9	-0.7	-1.9	1.0	-1.0	-0.3	-0.7	-0.3	-2.6	-2.3
Leg fat percentage (right)	0.7	2.7	9.7	0.4	0.2	-2.6	0.1	-0.3	-1.2	-0.3	-0.5	-3.1	-2.9
Arm fat-free mass (right)	0.6	3.1	9.0	-0.5	0.4	-2.7	-0.7	0.7	-1.9	-0.2	0.8	-3.0	-2.9
Exposure to tobacco smoke outside home	0.8	1.1	3.3	-0.9	0.5	-1.3	-1.0	0.7	-1.4	0.3	-0.4	-1.8	-1.0
Comparative body size at age 10	0.3	0.9	3.9	0.0	0.7	-0.2	-1.9	2.0	-0.3	-0.3	-0.4	0.2	-0.3
Number of full brothers	1.0	1.3	4.6	2.1	0.6	-0.5	-0.4	0.3	1.2	-1.1	1.8	-0.8	-1.0
Worry too long after embarrassment	0.7	1.2	3.4	0.6	-0.1	-1.0	-0.2	-0.1	-1.6	1.8	-1.8	0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	-1.2	-0.2	1.3	-1.0	0.4	0.1	-0.5	-0.0	1.4	1.1
Wheeze or whistling in the chest in last year	2.1	3.7	10.1	-2.0	-0.4	-2.0	0.3	-0.3	-3.2	2.8	-3.1	-1.0	-0.5
Number of children fathered	2.8	3.1	11.4	1.0	1.9	-2.2	-1.9	1.8	-0.3	-0.9	-0.1	-1.5	-3.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.1	0.3	-0.7	1.0	0.5	-0.6	0.3	0.7	-0.4	0.8	1.8
Age at first live birth	2.0	3.6	8.7	0.2	-0.3	2.8	0.3	0.1	2.3	-2.9	2.4	2.4	1.6
Pulse wave peak to peak time	1.1	1.2	3.6	1.2	0.8	1.3	-0.6	0.3	1.5	-1.1	0.3	1.9	1.1
Health satisfaction	0.6	0.8	1.6	1.1	1.3	-1.0	-0.4	-0.1	-0.8	0.5	-0.8	-0.9	-1.1
Shortness of breath walking on level ground	0.4	0.5	1.3	-0.8	-0.3	-0.7	-0.7	0.6	-1.1	0.3	-0.8	-0.7	-0.4
Qualifications: College or University degree	0.8	2.4	5.7	-1.7	0.2	2.1	-1.2	1.6	0.4	-2.4	1.6	1.7	1.3
Eye problems/disorders: None of the above	2.1	2.4	6.6	-2.6	-1.4	0.8	1.2	-1.2	-1.2	1.8	-1.5	0.8	2.2
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.8	0.7	-2.2	1.0	1.6	-1.6	-0.0	-1.9	0.4	-0.4	1.0
Emphysema/chronic bronchitis	1.7	2.0	5.2	-0.9	1.0	-2.3	-0.5	0.6	-1.5	2.2	-1.1	-0.7	-1.9
Medication for pain relief, constipation, heartburn	2.4	4.1	8.5	1.2	-1.6	2.9	1.2	-1.2	2.2	-1.9	2.0	2.4	2.7
Neck or shoulder pain in last month	1.3	1.9	3.3	-1.3	-0.5	-1.8	0.8	-0.9	-1.8	0.7	-1.7	-1.5	-1.8
Medication: Blood pressure	0.7	1.2	3.5	1.9	0.8	-0.7	-1.1	1.1	0.2	-0.6	-0.9	-0.4	-1.8
Angina (self-reported)	1.9	2.5	4.5	-0.6	-1.7	-1.5	2.1	-2.1	-1.7	1.3	-1.7	-1.7	-0.9
Migraine (self-reported)	1.8	2.3	6.1	-0.6	-0.1	-2.5	0.5	-0.1	-1.4	1.7	-1.8	-2.0	-2.0
Medication: Ibuprofen	0.6	0.7	1.5	-0.9	0.8	-0.4	-0.9	1.2	-0.9	0.9	-0.8	-0.5	-0.7
Medication: Allopurinol	3.0	4.0	9.9	2.7	1.6	-2.4	-1.0	0.8	1.2	-1.0	1.3	-3.0	-3.1
Medication: Omeprazole	0.3	0.4	0.9	0.6	0.8	-0.5	-0.7	0.6	0.3	1.0	-0.5	-0.5	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	2.0	-1.0	0.8	-0.5	-1.4	1.4	0.3	-0.6	0.2	-0.7	-0.8
Mean time to correctly identify matches	1.0	1.9	4.7	-1.6	-0.8	1.4	0.8	-1.0	-0.9	1.4	-0.4	2.1	2.2
Heart disease (mother)	0.5	0.6	1.9	1.0	-1.4	0.2	0.2	-0.0	0.9	-0.9	1.0	-0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	1.4	-1.4	-0.2	1.1	-1.0	-0.3	0.7	-0.2	-0.6	-0.2
Whole body fat mass	0.6	2.6	9.4	0.5	-0.2	-2.4	0.6	-0.6	-0.8	-0.7	-0.2	-3.1	-2.9
Leg fat mass (right)	1.0	3.8	12.9	0.5	0.0	-3.1	0.2	-0.2	-1.4	-0.3	-0.1	-3.6	-3.5
Arm predicted mass (right)	0.6	3.1	9.5	-0.4	0.6	-2.7	-0.7	0.7	-1.6	-0.3	1.0	-3.0	-3.1
Pulse rate, automated reading	0.8	2.5	8.0	1.0	2.6	0.1	-2.8	2.5	1.1	-0.7	0.7	0.4	-0.6
Alcohol intake frequency.	0.4	0.8	2.3	-0.7	0.8	-1.3	-0.5	0.7	-0.9	0.7	0.1	-1.5	-1.2
Comparative height size at age 10	0.4	2.4	8.4	0.1	0.4	-2.4	0.5	-0.4	-0.8	0.1	-0.2	-2.9	-2.9
Number of full sisters	0.9	1.1	2.4	1.1	0.8	-1.5	0.0	0.2	0.0	1.2	-1.2	-1.5	-1.2
Suffer from ‘nerves’	0.4	0.7	2.3	-0.5	-1.3	0.2	0.3	-1.0	-0.9	0.4	-1.5	0.7	-0.1
Overall health rating	1.7	3.6	7.8	1.5	2.3	-2.0	-2.8	2.3	-0.7	-0.4	-0.1	-1.9	-2.7
Chest pain or discomfort	0.4	0.5	1.3	-0.6	1.1	-0.1	-1.2	1.0	-0.8	0.8	-0.3	0.1	-0.2
Had major operations	2.1	2.5	6.0	0.5	1.6	1.2	-2.3	2.4	1.3	-1.2	2.0	0.9	1.1
Age at last live birth	1.7	2.4	4.9	0.3	0.3	2.2	-0.7	0.7	2.1	-2.2	2.1	1.7	1.3
Family relationship satisfaction	1.1	1.4	2.5	1.4	-1.6	-1.2	1.3	-1.4	-1.0	0.7	-0.2	-1.5	-0.2
Leg pain on walking	0.8	0.9	2.5	-1.4	-1.6	-0.6	1.1	-1.1	-0.8	0.0	0.4	-1.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.4	1.5	0.6	-0.9	0.9	-0.7	1.3	0.6	0.5	-0.7	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.6	-0.3	-0.3	-1.2	-0.3	0.1	-1.3	0.1	-0.8	-0.3	-1.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	6.4	-0.2	-1.3	0.8	2.5	-2.4	1.0	0.0	-0.0	0.7	1.2
Medication: Aspirin	0.2	0.3	1.1	0.4	0.2	-0.8	-0.1	0.2	-0.3	-0.2	0.3	-0.9	-1.0
Supplements: Vitamin C	1.1	1.3	4.1	-0.5	-2.0	1.2	1.0	-1.1	0.6	-0.0	1.0	0.7	1.7
Knee pain experienced in last month	1.0	1.5	3.7	-1.0	1.6	-1.0	-1.8	1.9	0.2	-0.8	-0.9	-0.6	-1.2
Hypertension (Self-reported)	1.9	5.3	20.3	4.5	1.3	-2.2	-2.0	1.9	0.4	-1.3	-0.2	-2.2	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	0.4	0.4	0.5	-0.3	0.5	0.1	0.4	-1.3	0.9	0.3
Illnesses of father: Heart disease	0.8	1.1	3.7	-0.0	0.0	1.0	-1.0	1.3	1.1	-1.9	1.4	0.7	0.4
Illnesses of siblings: Diabetes	0.6	0.8	2.2	0.3	1.5	-0.5	-1.3	1.4	0.5	-0.0	0.2	-0.3	-1.2
Smoking status: Previous	2.1	3.2	8.1	0.1	-1.5	-1.6	2.7	-2.9	-0.8	0.2	-1.0	-2.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	6.0	-1.1	-2.5	-1.8	1.9	-2.3	-1.5	1.1	-0.5	-1.7	-1.2
Whole body fat-free mass	0.5	2.7	8.4	-0.4	0.2	-2.4	-0.6	0.6	-1.4	-0.9	1.3	-2.8	-2.9
Leg fat-free mass (right)	0.3	1.7	5.3	0.3	0.1	-1.6	-0.4	0.6	-0.6	-1.3	1.4	-2.0	-2.3
Arm fat percentage (left)	0.2	0.8	2.1	1.1	-0.4	-0.9	0.5	-0.5	0.5	-1.1	0.3	-1.4	-1.5
Average weekly red wine intake	0.6	0.9	2.4	-0.6	-1.2	1.2	-0.1	-0.0	0.4	-0.6	1.1	1.6	1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	-1.0	-1.5	-0.1	-0.2	-0.6	-0.8	-0.2	0.4	-1.2	-0.0
Mood swings	0.9	1.6	4.5	-0.4	0.8	-2.1	-0.9	0.5	-1.8	0.9	-0.6	-0.9	-2.1
Loneliness, isolation	1.2	1.7	5.3	0.2	-1.2	-1.9	0.4	-0.7	-1.5	0.2	-0.1	-2.3	-1.9
Long-standing illness, disability or infirmity	1.5	2.3	6.0	0.0	0.1	-2.4	-0.6	0.5	-1.9	0.9	-1.0	-2.5	-2.3
Ever had bowel cancer screening	0.9	1.0	2.2	0.8	0.4	1.5	0.7	-0.4	1.4	-1.2	1.1	1.1	0.9
Diabetes diagnosed by doctor	1.4	2.3	7.9	2.8	0.6	-0.7	-0.3	0.6	1.6	-1.9	2.0	-1.3	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.4	0.3	-0.1	-1.2	-0.1	-0.1	0.2	-0.1	-0.5	-0.6	-1.2
Friendships satisfaction	0.3	0.3	0.7	0.7	-0.6	0.4	0.6	-0.8	-0.3	-0.6	-0.2	-0.1	0.8
Qualifications: nursing, teaching	0.5	0.8	3.0	-0.7	0.6	1.1	-0.5	1.4	-0.1	-0.6	-0.5	1.7	0.6
Commuting to job workplace: Walk	0.8	0.9	2.4	-1.6	0.6	1.4	-0.3	0.1	-0.2	-0.1	-0.6	1.2	1.4
Eye problems/disorders: Cataract	0.5	0.6	3.5	0.6	0.9	-0.1	-0.2	0.4	0.3	-1.9	0.3	-0.3	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.7	0.0	-0.2	1.9	-0.8	0.3	0.8	-0.3	-0.1	1.9	2.2
Medication for cholesterol	0.8	1.2	5.1	-2.3	-0.8	1.0	1.1	-1.1	0.2	0.3	0.4	0.9	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	-1.0	-0.4	-0.1	0.7	-0.2	-0.4	-0.8	0.1	-0.1	-0.4
Back pain experienced in last month	0.2	0.2	0.7	0.6	-0.9	0.2	0.1	-0.3	0.4	-0.2	0.8	-0.0	0.5
Mineral and other dietary supplements	0.3	0.4	1.7	0.2	0.3	0.9	0.2	-0.7	0.3	-1.3	-0.4	0.3	0.3
Breast cancer (self-reported)	2.2	2.7	5.4	-1.3	2.2	-0.9	-1.5	2.0	-1.4	2.0	-2.3	-0.4	-1.2
Asthma (self-reported)	0.9	1.7	6.0	-2.1	-0.1	-0.9	0.3	-0.4	-1.7	1.5	-2.5	-0.4	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.0	0.4	-0.8	-0.1	0.0	-0.7	0.6	-0.2	-0.1	-0.6
Osteoarthritis (self-reported)	0.8	1.1	2.9	-0.7	1.5	0.1	-1.4	1.7	0.2	-0.6	-1.4	0.3	-0.7
Medication: Aspirin	0.3	0.4	1.3	0.7	0.5	-0.8	-0.3	0.5	-0.1	-0.4	0.3	-0.7	-1.2
Medication: Gliclazide	1.0	1.1	2.6	1.6	0.6	-0.2	0.1	0.1	1.6	-1.4	1.5	-0.2	-1.0
Illnesses of father: None of the above (group 1)	2.3	2.8	11.5	-1.2	1.1	-2.1	0.2	-0.6	-1.6	3.4	-2.2	-1.2	-0.9
Smoking status: Current	1.4	2.2	8.3	2.0	-0.1	-2.2	-0.3	0.3	0.3	-0.5	1.2	-2.9	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.8	-0.9	1.5	-1.3	-0.9	0.9	-1.1	1.0	-1.9	-1.6	-1.1
Whole body water mass	0.5	2.9	9.5	-0.4	0.3	-2.5	-0.7	0.6	-1.3	-1.0	1.3	-2.9	-3.1
Leg predicted mass (right)	0.3	1.7	5.2	0.4	0.0	-1.6	-0.4	0.6	-0.6	-1.3	1.3	-2.0	-2.3
Arm fat mass (left)	0.4	1.5	5.7	0.5	-0.1	-1.8	0.2	-0.2	-0.4	-0.9	0.3	-2.4	-2.2
Number of self-reported non-cancer illnesses	2.1	3.7	11.0	1.5	0.4	-3.3	-1.2	1.0	-1.3	1.2	-1.0	-2.6	-3.2
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.2	0.8	0.7	0.7	-0.2	1.0	-0.2	-0.8	1.2	0.2
Miserableness	1.0	1.8	4.0	-0.2	0.6	-2.0	-1.1	0.8	-2.0	0.2	-1.3	-1.4	-1.9
Guilty feelings	2.3	3.5	11.1	-1.2	-1.2	-2.3	0.5	-0.8	-3.3	2.4	-2.2	-1.3	-1.5
Wears glasses or contact lenses	0.4	0.4	1.9	0.2	-0.3	-1.0	0.1	-0.1	0.3	0.3	0.8	-1.4	-0.7
Ever taken oral contraceptive pill	0.5	0.5	2.0	-0.2	0.4	0.5	-0.9	0.8	1.4	0.2	0.6	0.9	0.6
Hearing aid user	0.8	0.9	2.2	-0.7	0.5	1.5	-1.1	0.9	-0.1	-0.9	0.3	0.9	1.4
Mother’s age at death	0.9	1.1	4.5	-1.3	0.4	1.2	-0.6	0.9	-0.2	0.4	-0.2	2.1	1.4
Financial situation satisfaction	0.5	0.6	2.5	1.6	0.4	-0.6	-0.4	0.2	-0.4	-0.8	0.1	-0.7	-1.1
Tinnitus: Yes, now most or all of the time	1.4	1.7	6.3	0.1	1.9	-0.4	-2.5	2.3	0.5	0.1	0.2	0.0	-0.8
Commuting to job workplace: Public transport	1.4	1.6	3.5	-0.1	0.1	1.8	-1.0	0.9	1.6	-1.0	1.9	1.0	1.8
Eye problems/disorders: Glaucoma	5.4	6.4	20.8	0.3	1.0	-4.5	-1.0	1.2	-1.8	1.4	0.0	-3.8	-4.6
Medication: Blood pressure	1.2	2.3	10.9	3.3	1.2	-1.3	-1.4	1.4	0.5	-0.4	-0.1	-1.3	-1.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.3	0.1	0.6	-1.7	-1.0	0.3	-0.5	-0.3	0.0	-2.3	-2.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	0.3	-0.6	-0.4	0.8	-0.2	0.3	0.6	0.5	-0.8	0.1
High cholesterol (Self-reported)	0.7	1.2	4.0	0.5	0.7	-2.0	0.1	0.1	-0.1	0.5	0.5	-1.9	-1.9
Medication: Bendroflumethiazide	1.9	2.9	8.5	2.9	1.8	-1.1	-2.7	2.2	0.5	-0.2	0.8	-0.9	-1.5
Medication: Paracetamol	3.2	4.9	9.5	-1.2	2.4	-3.1	-2.5	2.4	-1.5	1.5	-1.8	-1.9	-2.9
Medication: Lisinopril	1.1	1.4	4.4	2.1	0.2	0.5	-1.2	1.6	1.6	-1.4	0.8	0.4	-0.1
Medication: Atorvastatin	1.5	1.8	4.7	-2.1	0.2	-1.6	-0.6	0.2	-2.2	1.7	-0.7	-1.5	-0.7
Illnesses of father: High blood pressure	0.9	1.2	3.0	1.3	0.8	0.3	-1.6	1.7	0.3	-1.7	0.7	0.1	-0.3
Alcohol drinker status: Never	0.4	0.5	2.5	-1.6	-0.2	-0.1	0.0	0.1	-1.3	0.7	0.2	-0.3	-0.4
Ever smoked	1.2	2.2	6.2	0.9	-1.4	-2.0	1.3	-1.6	-1.1	0.6	-0.7	-2.5	-1.4
Basal metabolic rate	0.6	3.1	10.2	-0.3	0.1	-2.7	-0.4	0.3	-1.4	-0.9	1.0	-3.1	-3.2
Leg fat percentage (left)	0.7	2.5	7.8	-0.0	-0.0	-2.5	-0.0	-0.2	-1.6	0.3	-1.0	-2.8	-2.6
Arm fat-free mass (left)	0.8	4.0	12.2	-1.3	0.1	-3.2	-0.4	0.2	-2.2	0.2	0.4	-3.5	-3.3
Number of operations (self-reported)	0.8	1.1	4.4	-0.3	1.4	0.3	-2.1	2.0	0.2	-0.5	0.6	0.3	0.2
Average weekly beer plus cider intake	0.8	1.2	3.4	1.4	-0.7	-0.4	1.8	-1.9	-0.1	1.4	-0.7	-0.2	0.2
Irritability	1.7	2.8	9.6	-0.6	-3.1	1.3	1.9	-2.4	-0.5	-1.8	1.0	1.2	1.1
Risk taking	0.5	0.8	2.7	-0.0	-1.1	-0.8	0.2	-0.6	0.6	-0.5	1.5	-1.6	-0.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.2	-2.1	1.0	-1.5	-0.9	0.9	-0.8	0.2	-0.2	-0.3	-2.0
Fractured/broken bones in last 5 years	2.5	3.2	10.4	-1.1	0.5	-1.3	-0.2	0.5	-2.9	3.2	-3.1	-0.2	-0.3
Age started oral contraceptive pill	1.0	1.2	2.7	-0.7	1.7	1.1	-1.3	1.6	0.7	0.5	0.0	1.3	1.1
Diastolic blood pressure, automated reading	0.4	1.3	5.0	0.4	0.2	-1.0	-0.5	0.3	-2.0	1.4	-2.2	0.1	-0.8
Ever depressed for a whole week	1.9	2.4	6.7	-1.1	-0.6	-1.8	0.9	-0.8	-2.0	2.6	-2.3	-1.1	-0.4
Unable to work because of sickness or disability	0.5	0.6	1.5	0.6	-0.9	-0.7	0.7	-1.2	-0.9	0.4	0.0	-1.1	-0.4
Commuting to job workplace: Cycle	0.7	0.8	2.5	-1.4	-0.2	0.6	0.9	-0.8	-0.5	0.7	-0.1	1.6	0.9
Myopia	0.7	1.1	4.3	0.3	1.6	-0.4	-1.7	2.1	-0.2	0.7	-0.4	-0.5	-0.2
Vascular/heart problems diagnosed by doctor	1.4	3.8	16.5	-4.1	-0.4	1.9	1.0	-0.9	-0.4	1.6	-0.1	2.1	3.0
Cholesterol lowering medication	2.0	2.9	8.9	0.4	0.7	-3.0	-0.9	0.8	-1.1	1.1	-0.4	-2.9	-2.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.8	1.0	-0.5	-0.6	0.8	0.4	0.7	-0.2	-0.4	-0.2
Pain experienced in last month	1.3	2.1	5.5	-0.5	-1.4	1.7	1.2	-0.9	0.2	0.8	1.7	2.1	2.3
Supplements: Calcium	0.8	0.9	2.1	-0.3	-0.0	-1.3	-0.9	1.4	-1.2	1.1	-0.2	-0.4	-1.1
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	1.1	1.1	-0.4	-0.8	0.9	-0.1	0.5	-1.1	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	0.1	-1.0	0.2	1.0	-1.1	0.1	-0.7	-0.1	-0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.1	0.2	0.4	0.0	-1.1	0.7	0.4	0.9	0.7	1.4	0.3
Heart disease (siblings)	1.3	1.6	3.2	1.6	1.5	-0.5	-1.8	1.4	1.3	-0.9	1.0	-1.0	-1.0
Alcohol drinker status: Previous	0.4	0.4	1.2	0.8	-0.2	0.1	1.1	-1.1	0.9	-0.3	0.5	-0.2	0.4
Pack years of smoking	0.5	0.8	2.3	1.5	-1.0	0.1	1.2	-1.4	0.4	-0.8	0.5	-0.4	0.2
Impedance of whole body	0.5	2.4	8.2	0.2	-1.7	0.9	2.7	-2.9	0.7	0.5	-1.6	0.3	1.2
Leg fat mass (left)	1.0	3.8	12.5	0.2	-0.0	-3.2	0.2	-0.2	-1.7	0.1	-0.5	-3.5	-3.5
Arm predicted mass (left)	0.8	3.9	11.6	-1.0	0.4	-3.1	-0.5	0.4	-2.1	-0.1	0.5	-3.4	-3.4