[Hub]/) : Traits : Breast Cancer : ←

chr22:37,643,564-41,895,409

Best TWAS P=1.73e-33 · Best GWAS P=1.05e-34 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MCHR1	0.15	0.07	lasso	7	0.14	7.5e-17	1.3	-5.9	4.3e-09	0.40	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SLC25A17	0.03	0.01	blup	301	0.01	9.6e-03	1.6	-6.4	1.6e-10	0.56	0.16	0.21	FALSE
3	GTEx	Adipose Subcutaneous	TMEM184B	0.08	0.08	lasso	4	0.07	1.0e-06	4.6	-5.7	1.1e-08	0.06	0.52	0.46	FALSE
4	GTEx	Artery Aorta	C22orf23	0.10	0.01	enet	24	0.02	1.6e-02	3.2	5.8	7.8e-09	0.02	0.24	0.14	TRUE
5	GTEx	Artery Aorta	PLA2G6	0.10	0.02	enet	9	0.02	4.5e-02	4.3	6.0	2.2e-09	-0.02	0.04	0.76	FALSE
6	GTEx	Artery Aorta	TMEM184B	0.17	0.07	enet	34	0.03	1.2e-02	5.7	-5.3	8.8e-08	0.01	0.18	0.18	FALSE
7	GTEx	Brain Cerebellum	TNRC6B	0.13	0.14	lasso	6	0.09	1.2e-03	-8.1	-9.1	1.2e-19	0.49	0.06	0.68	FALSE
8	GTEx	Brain Frontal Cortex BA9	SLC25A17	0.11	-0.01	lasso	5	0.00	3.5e-01	-8.1	-7.8	4.2e-15	0.55	0.04	0.55	TRUE
9	GTEx	Cells Transformed fibroblasts	PLA2G6	0.23	0.09	lasso	9	0.10	9.9e-08	6.9	6.5	6.1e-11	0.00	0.06	0.94	FALSE
10	GTEx	Cells Transformed fibroblasts	MAFF	0.08	0.08	lasso	3	0.06	2.2e-05	6.9	-6.8	1.1e-11	0.08	0.03	0.93	FALSE
11	GTEx	Esophagus Mucosa	PLA2G6	0.22	0.02	lasso	6	0.04	1.9e-03	6.9	6.6	3.5e-11	-0.02	0.03	0.96	FALSE
12	GTEx	Esophagus Muscularis	TMEM184B	0.11	0.01	enet	10	0.06	2.7e-04	3.1	-5.2	2.1e-07	0.01	0.10	0.71	FALSE
13	GTEx	Muscle Skeletal	MKL1	0.05	0.02	enet	26	0.03	4.2e-04	-11.6	7.6	3.9e-14	-0.67	0.07	0.90	FALSE
14	GTEx	Nerve Tibial	PLA2G6	0.34	0.08	lasso	8	0.11	2.9e-08	-4.1	5.8	5.1e-09	-0.01	0.12	0.88	FALSE
15	GTEx	Nerve Tibial	MAFF	0.14	0.06	lasso	3	0.05	1.2e-04	6.3	-6.2	4.0e-10	0.00	0.44	0.47	FALSE
16	GTEx	Nerve Tibial	AL021977.1	0.16	0.05	lasso	3	0.07	9.3e-06	4.4	-5.2	2.2e-07	0.06	0.23	0.75	FALSE
17	GTEx	Skin Sun Exposed Lower leg	BAIAP2L2	0.09	0.09	lasso	4	0.09	5.5e-08	6.5	-7.0	2.1e-12	0.01	0.02	0.98	TRUE
18	GTEx	Thyroid	TMEM184B	0.19	0.16	lasso	7	0.18	1.0e-13	4.6	-6.2	6.8e-10	0.06	0.18	0.82	FALSE
19	GTEx	Thyroid	AL021977.1	0.20	0.11	lasso	6	0.12	2.7e-09	4.4	-5.7	1.3e-08	0.05	0.22	0.78	FALSE
20	NTR	Blood	APOBEC3B	0.30	0.08	enet	50	0.12	3.1e-38	-4.6	-5.2	2.6e-07	0.01	0.02	0.96	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNRC6B	0.02	0.01	blup	92	0.01	2.7e-03	-6.6	-8.7	4.7e-18	0.38	0.08	0.08	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	MKL1	0.05	0.03	blup	105	0.04	3.9e-03	-12.1	-12.1	1.7e-33	0.87	0.02	0.66	TRUE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADSL	0.04	0.03	enet	6	0.03	1.6e-04	-6.0	-6.6	3.9e-11	0.29	0.04	0.37	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOBEC3A	0.11	0.03	blup	15	0.03	3.2e-04	4.0	5.4	5.2e-08	-0.05	0.00	0.14	TRUE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOBEC3B	0.20	0.01	enet	9	0.04	2.0e-05	-2.7	5.3	1.4e-07	-0.03	0.00	0.00	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADSL	0.07	0.02	blup	33	0.05	5.2e-04	-8.4	-9.3	1.0e-20	0.50	0.02	0.86	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNRC6B	0.05	0.03	lasso	8	0.04	6.9e-06	-8.5	-8.2	3.4e-16	0.45	0.28	0.67	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ADSL	0.06	0.01	blup	33	0.03	1.1e-02	-8.5	-7.1	1.7e-12	0.42	0.08	0.11	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	-5.7	-8.6	6.1e-18	0.45	0.01	0.55	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SGSM3	0.02	0.00	enet	12	0.00	3.7e-01	-10.1	-8.7	4.8e-18	0.52	0.05	0.43	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADSL	0.06	0.02	lasso	2	0.03	6.6e-03	-5.7	-5.7	1.3e-08	0.29	0.02	0.22	TRUE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADSL	0.09	0.03	lasso	3	0.01	7.7e-02	-6.2	-8.7	5.0e-18	0.44	0.01	0.62	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TNRC6B	0.12	0.05	lasso	4	0.05	4.2e-03	-10.1	-8.3	1.4e-16	0.54	0.00	0.98	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	ADSL	0.14	0.05	lasso	3	0.06	1.5e-04	-5.7	-8.2	2.7e-16	0.43	0.17	0.72	TRUE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADSL	0.04	0.00	blup	33	0.03	2.6e-03	-8.5	-8.1	7.5e-16	0.42	0.07	0.17	TRUE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	MKL1	0.05	0.01	blup	95	0.02	2.2e-02	6.4	-11.1	1.2e-28	0.66	0.12	0.16	TRUE
37	The Cancer Genome Atlas	Thyroid Carcinoma	PLA2G6	0.03	0.02	lasso	2	0.03	6.5e-04	5.5	5.5	3.0e-08	0.02	0.09	0.14	FALSE