[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr16:49,403,920-51,535,063

Best TWAS P=3.32e-78 · Best GWAS P=1.82e-108 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	The Cancer Genome Atlas	Lung Adenocarcinoma	NOD2	0.07	0.01	lasso	4	0.02	1.1e-03	22.1	18.7	3.3e-78	0.78	0.00	0.91	TRUE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	CYLD	0.03	0.00	blup	69	0.02	3.8e-03	-12.9	18.1	2.8e-73	0.60	0.11	0.66	TRUE
35	GTEx	Skin Not Sun Exposed Suprapubic	NOD2	0.15	0.06	lasso	4	0.02	1.9e-02	-12.8	13.1	2.7e-39	0.46	0.54	0.24	TRUE
38	GTEx	Testis	NKD1	0.24	0.13	lasso	4	0.14	8.1e-07	8.3	9.9	6.6e-23	0.10	0.76	0.01	TRUE
21	GTEx	Colon Transverse	NKD1	0.22	0.00	enet	42	0.05	2.5e-03	-2.2	-8.6	5.7e-18	-0.17	0.21	0.11	TRUE
45	METSIM	Adipose	ADCY7	0.04	0.00	enet	22	0.01	1.7e-02	1.8	-8.2	1.9e-16	-0.03	0.20	0.04	TRUE
43	GTEx	Whole Blood	BRD7	0.16	0.12	enet	9	0.12	4.2e-11	-6.0	-6.2	5.4e-10	0.00	1.00	0.00	TRUE
32	GTEx	Nerve Tibial	RP11-429P3.3	0.18	0.12	enet	13	0.12	1.7e-08	5.1	-5.5	4.4e-08	-0.08	1.00	0.00	TRUE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADCY7	0.03	0.01	blup	52	0.02	6.6e-03	-4.8	-5.5	5.0e-08	-0.04	0.02	0.03	TRUE
29	GTEx	Muscle Skeletal	HEATR3	0.17	0.17	lasso	8	0.15	1.1e-14	5.4	-5.4	7.7e-08	-0.11	1.00	0.00	TRUE
50	NTR	Blood	NOD2	0.15	0.18	lasso	4	0.18	7.1e-57	-4.2	-5.1	2.8e-07	-0.35	1.00	0.00	TRUE
23	GTEx	Esophagus Mucosa	CYLD	0.13	0.06	enet	10	0.06	7.0e-05	-12.9	17.8	4.8e-71	0.72	0.06	0.93	FALSE
24	GTEx	Esophagus Mucosa	NOD2	0.19	0.14	lasso	7	0.15	4.1e-10	-12.8	13.5	9.8e-42	0.46	0.99	0.01	FALSE
30	GTEx	Nerve Tibial	CYLD	0.10	0.00	lasso	6	0.00	1.7e-01	10.4	10.4	3.4e-25	0.37	0.10	0.05	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYLD	0.03	0.03	enet	7	0.02	9.3e-04	-12.7	9.3	1.2e-20	0.29	0.26	0.04	FALSE
13	GTEx	Brain Hypothalamus	CYLD	0.38	0.13	enet	36	0.15	2.7e-04	-12.2	-7.8	9.1e-15	-0.28	0.14	0.09	FALSE
51	YFS	Blood	PAPD5	0.03	0.01	enet	13	0.02	1.4e-07	-6.2	-7.0	3.1e-12	0.02	0.96	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	HEATR3	0.67	0.49	enet	36	0.52	1.4e-15	5.0	-6.7	2.8e-11	-0.13	1.00	0.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	HEATR3	0.28	0.20	enet	47	0.23	7.4e-19	5.1	-6.6	5.0e-11	-0.11	1.00	0.00	FALSE
39	GTEx	Testis	HEATR3	0.47	0.37	enet	33	0.38	4.5e-18	5.1	-6.5	6.6e-11	-0.10	1.00	0.00	FALSE
6	GTEx	Artery Tibial	RP11-429P3.3	0.09	0.05	lasso	3	0.04	5.9e-04	5.8	-6.5	1.1e-10	-0.15	0.34	0.06	FALSE
26	GTEx	Heart Left Ventricle	HEATR3	0.29	0.14	enet	25	0.22	8.4e-12	5.1	-6.3	4.1e-10	-0.09	1.00	0.00	FALSE
3	GTEx	Artery Aorta	HEATR3	0.41	0.41	enet	62	0.42	5.4e-25	5.0	-6.2	5.9e-10	-0.08	1.00	0.00	FALSE
44	GTEx	Whole Blood	RP11-429P3.3	0.08	0.01	enet	12	0.01	2.6e-02	-4.8	-6.1	1.2e-09	-0.12	0.24	0.03	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEATR3	0.14	0.04	blup	39	0.08	3.2e-04	5.4	-6.1	1.3e-09	-0.08	0.03	0.53	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADCY7	0.10	0.02	enet	23	0.05	7.8e-07	-2.8	6.0	1.5e-09	0.02	0.60	0.02	FALSE
37	GTEx	Stomach	HEATR3	0.36	0.27	enet	14	0.28	1.6e-13	5.4	-6.0	1.7e-09	-0.13	1.00	0.00	FALSE
27	GTEx	Lung	HEATR3	0.34	0.40	enet	19	0.41	6.4e-34	5.0	-5.9	2.9e-09	-0.12	1.00	0.00	FALSE
49	NTR	Blood	HEATR3	0.02	0.00	blup	386	0.01	1.4e-04	3.0	-5.9	3.6e-09	-0.09	0.89	0.00	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	HEATR3	0.36	0.20	enet	18	0.24	3.8e-07	5.1	-5.9	3.9e-09	-0.10	0.91	0.00	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	HEATR3	0.36	0.26	lasso	6	0.25	1.7e-09	5.0	-5.8	4.9e-09	-0.09	1.00	0.00	FALSE
5	GTEx	Artery Tibial	HEATR3	0.27	0.31	enet	17	0.32	2.1e-25	5.1	-5.8	5.3e-09	-0.09	1.00	0.00	FALSE
28	GTEx	Lung	RP11-429P3.3	0.08	0.09	lasso	2	0.08	5.1e-07	5.8	-5.8	6.2e-09	-0.13	0.99	0.00	FALSE
33	GTEx	Pituitary	HEATR3	0.55	0.36	lasso	7	0.48	1.3e-13	5.0	-5.8	7.1e-09	-0.12	0.99	0.00	FALSE
48	NTR	Blood	ADCY7	0.07	0.06	enet	17	0.07	2.0e-20	-6.1	-5.7	1.5e-08	0.01	1.00	0.00	FALSE
10	GTEx	Brain Cerebellum	RP11-429P3.3	0.40	0.22	enet	11	0.26	1.9e-08	5.0	-5.6	1.7e-08	-0.11	0.91	0.01	FALSE
46	METSIM	Adipose	BRD7	0.06	0.05	lasso	6	0.05	1.1e-07	-6.0	-5.6	1.7e-08	0.01	1.00	0.00	FALSE
14	GTEx	Brain Hypothalamus	HEATR3	0.26	0.01	lasso	6	0.01	1.9e-01	5.0	-5.5	4.2e-08	-0.10	0.09	0.16	FALSE
4	GTEx	Artery Coronary	HEATR3	0.30	0.25	lasso	5	0.25	6.0e-09	5.0	-5.5	4.6e-08	-0.11	0.97	0.00	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	HEATR3	0.16	0.20	blup	39	0.21	6.4e-20	5.0	-5.4	5.8e-08	-0.09	0.26	0.74	FALSE
41	GTEx	Thyroid	HEATR3	0.34	0.37	enet	19	0.37	6.6e-30	5.0	-5.4	6.3e-08	-0.09	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue (Male)	HEATR3	0.36	0.33	lasso	5	0.31	5.9e-08	5.4	-5.4	6.4e-08	-0.11	0.53	0.03	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	HEATR3	0.22	0.25	lasso	5	0.25	1.1e-08	5.4	-5.4	7.5e-08	-0.11	0.95	0.00	FALSE
31	GTEx	Nerve Tibial	HEATR3	0.38	0.39	lasso	9	0.38	6.5e-28	5.4	-5.3	1.1e-07	-0.11	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	HEATR3	0.13	0.07	blup	39	0.10	5.1e-04	4.8	-5.3	1.2e-07	-0.12	0.07	0.55	FALSE
9	GTEx	Brain Cerebellum	HEATR3	0.70	0.66	lasso	7	0.69	1.4e-27	5.0	-5.3	1.3e-07	-0.10	1.00	0.00	FALSE
47	METSIM	Adipose	HEATR3	0.18	0.23	lasso	7	0.23	1.9e-33	5.1	-5.3	1.3e-07	-0.10	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	HEATR3	0.40	0.38	lasso	8	0.39	6.1e-25	5.1	-5.3	1.4e-07	-0.10	1.00	0.00	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	HEATR3	0.22	0.18	lasso	9	0.18	5.0e-10	5.1	-5.2	1.5e-07	-0.10	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	HEATR3	0.17	0.19	lasso	8	0.20	2.3e-16	5.1	-5.2	1.7e-07	-0.11	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	HEATR3	0.36	0.14	lasso	12	0.20	2.6e-06	5.1	-5.2	1.8e-07	-0.11	0.73	0.01	FALSE
19	GTEx	Cells Transformed fibroblasts	ADCY7	0.11	0.14	lasso	2	0.14	1.1e-10	-4.8	-5.2	1.8e-07	-0.07	1.00	0.00	FALSE
12	GTEx	Brain Hippocampus	HEATR3	0.27	0.23	enet	9	0.19	3.9e-05	5.0	-5.2	1.9e-07	-0.10	0.29	0.06	FALSE
42	GTEx	Whole Blood	HEATR3	0.12	0.09	lasso	6	0.08	1.3e-07	5.4	-5.2	1.9e-07	-0.10	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	HEATR3	0.27	0.32	lasso	5	0.28	1.6e-10	5.1	-5.2	2.0e-07	-0.10	1.00	0.00	FALSE
40	GTEx	Testis	RP11-429P3.3	0.21	0.03	lasso	5	0.03	1.6e-02	5.1	-5.2	2.0e-07	-0.10	0.13	0.05	FALSE
16	GTEx	Breast Mammary Tissue	HEATR3	0.33	0.26	lasso	6	0.25	2.6e-13	5.1	-5.2	2.1e-07	-0.09	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	PAPD5	0.02	0.03	lasso	1	0.02	1.8e-03	5.2	-5.2	2.1e-07	-0.10	0.08	0.32	FALSE
11	GTEx	Brain Cortex	HEATR3	0.51	0.46	lasso	11	0.47	8.5e-15	5.0	-5.2	2.2e-07	-0.11	1.00	0.00	FALSE