Hub : Genes

CYLD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.3780	0.0990	0.00049	0.130	NA	0.146	NA	0.095	6.0e-04	NA	0.00027	NA	0.0031
2	GTEx	Esophagus Mucosa	0.1300	0.0370	0.00011	0.064	NA	0.060	NA	0.050	4.2e-05	NA	0.00007	NA	0.0003
3	GTEx	Nerve Tibial	0.1000	0.0372	0.00280	-0.002	NA	-0.002	NA	0.003	4.6e-01	NA	0.46000	NA	0.1700
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1890	0.0600	0.00051	0.014	NA	0.032	NA	0.021	5.1e-02	NA	0.00720	NA	0.0230
5	TCGA	Brain Lower Grade Glioma	0.0273	0.0154	0.00230	0.034	0.019	0.024	NA	0.019	9.2e-05	0.0025	0.00093	NA	0.0030
6	TCGA	Lung Adenocarcinoma	0.0252	0.0133	0.00170	0.003	0.017	0.006	NA	0.004	1.3e-01	0.0038	0.06400	NA	0.0900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	6.2	-0.2	-0.9	-1.3	-2.5	-1.5	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.2	2.8	-1.7	1.4	0.4	-0.1	1.0	1.1
Depressed Affect (Nagel 2018)	0.7	1.4	2.9	-0.2	0.4	1.7	1.5	1.4	1.1
Depression (Nagel 2018)	1.5	2.2	3.5	-1.9	1.4	1.7	-0.2	1.7	1.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	-0.3	-1.1	-0.5	-0.3	-0.6	-1.3
Neuroticism (Nagel 2018)	1.8	4.2	7.9	-0.8	1.7	2.5	0.4	2.8	2.7
Schizophrenia (2018)	2.5	5.1	6.7	-2.0	2.6	1.9	1.9	2.5	2.5
Schizophrenia vs Biploar Disorder	5.0	6.6	9.8	-2.2	3.1	2.4	1.9	2.5	3.1
Worry (Nagel 2018)	2.3	4.8	10.0	-0.9	2.2	2.3	0.3	3.2	2.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.2	-0.1	0.5	-0.5	0.4	-0.5	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.7	0.1	-0.5	0.9	-0.6	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-0.6	-0.5	-0.9	0.3	-1.0	-1.0
Crohns Disease (2017)	68.5	150.3	327.9	-7.8	17.8	10.4	1.3	9.3	18.1
Irritable Bowel Disease (IBD)	28.2	67.2	141.6	-6.2	11.9	6.7	1.0	6.0	11.9
Ulcerative Colitis (UC)	1.2	2.3	5.5	-2.3	1.7	1.1	0.1	1.4	1.6
Major Depression (MDD)	0.7	0.8	1.6	-0.9	0.9	0.7	1.3	0.5	1.1
Reaction Time	0.2	0.4	1.0	0.9	-0.4	-0.3	-1.0	-0.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.0	1.2	-1.2	-1.4	-0.4	-0.7	-1.3
Breast Cancer	0.3	0.6	2.4	0.1	0.0	0.8	0.7	1.5	0.5
Ovarian Cancer	0.5	0.7	2.7	1.7	-0.7	-0.6	-0.3	-0.3	-0.6
Prostate Cancer	1.6	2.3	4.9	1.7	-2.2	-1.5	-1.2	-0.3	-1.5
Age at First Birth	1.5	2.2	5.1	0.6	-1.4	-1.7	0.9	-2.3	-1.4
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.1	0.3	-0.5	-0.8	0.3	0.2
Body Mass Index (BMI) (2010)	0.3	0.5	1.4	-1.2	0.4	0.6	-0.5	0.4	0.6
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.4	-0.5	-0.3	-0.5	-0.9	-0.9
Crohns Disease (2012)	50.2	80.9	181.3	-4.9	13.2	7.4	1.6	7.1	13.5
Mean Putamen Volume	0.4	0.5	0.8	-0.7	0.8	0.9	0.2	0.2	0.8
Fasting Glucose	1.9	2.3	3.2	1.4	-1.8	-1.8	-0.7	-1.5	-1.6
HbA1C	0.4	0.4	1.1	0.5	-0.1	0.2	-1.0	1.0	0.4
HDL Cholesterol	0.4	0.6	1.8	1.4	-0.5	-0.8	0.5	-0.3	-0.7
LDL Cholesterol	0.7	1.2	2.6	0.6	-1.3	-1.6	-0.0	-1.2	-0.9
Lupus	1.9	2.9	4.4	1.7	-2.0	-2.1	1.1	-1.0	-1.9
Neuroticism (2016)	0.7	0.9	1.5	-0.4	0.8	1.2	0.9	1.1	1.2
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.6	0.7	0.6	-0.3	-0.5	0.7
Rheumatoid Arthritis	0.5	0.7	2.0	0.0	-0.1	-0.6	-1.4	-1.3	-0.0
Schizophrenia (2014)	1.4	3.0	5.0	-1.7	1.9	1.3	0.9	2.2	2.0
Triglycerides	0.3	0.4	1.4	0.0	0.4	-0.6	-1.2	0.4	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	-1.0	0.8	1.0	0.2	0.2	1.2
Ulcerative Colitis	1.2	1.7	5.7	-2.4	1.4	0.8	0.1	0.9	1.1
Blood Eosinophil Count	0.3	2.3	6.1	1.3	-1.0	-1.4	2.5	-1.3	-1.1
Blood Platelet Count	0.1	0.8	2.0	-0.4	-0.8	0.9	1.4	1.0	-0.6
Blood Red Count	0.2	1.5	4.0	-0.5	-2.0	0.8	1.2	0.9	-1.4
Blood White Count	0.2	1.6	3.0	-0.7	-1.6	-1.7	1.1	-1.0	-1.3
Heel T-Score	0.2	1.4	4.5	-0.7	0.4	2.1	-0.7	-1.5	0.6
BMI	0.2	0.9	3.1	-0.1	-1.8	-0.6	0.2	0.4	-1.3
Height	0.1	2.2	7.8	0.7	-1.1	-0.7	0.5	-2.8	-1.7
Waist Hip Ratio (WHR)	0.2	0.9	2.9	1.7	-0.0	-0.7	0.0	-1.3	-0.3
Systolic Blood Pressure	0.2	0.8	3.0	1.7	-1.1	0.4	-0.4	0.4	-0.2
Smoking Status	1.0	2.5	6.5	-2.5	1.3	0.9	1.5	1.3	1.4
Allergy or Eczema	0.3	0.7	2.0	-0.4	1.4	0.4	0.1	0.3	1.4
Cardiovascular Disease	0.1	0.4	1.1	0.5	-0.7	-0.1	-1.0	0.7	-0.2
Hypothyroidism (self reported)	3.0	7.0	9.5	2.1	-2.0	-2.7	-3.0	-3.1	-2.8
Respiratory disease	0.4	0.9	3.2	-0.8	0.6	-0.5	1.8	0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.9	-1.1	-0.6	-1.2	-0.8	-0.4
Lung FEV1/FVC ratio	0.1	0.4	1.3	0.2	0.5	0.9	-0.1	1.1	0.3
Lung FVC	0.2	1.0	1.7	-1.3	0.8	1.0	1.3	-0.2	1.1
Neuroticism	3.3	7.9	15.0	-1.2	2.4	3.2	1.8	3.9	3.5
Chronotype (morning person)	0.4	1.0	2.1	0.6	-0.7	-1.4	0.3	-1.4	-0.8
Hair Pigment	0.0	0.5	2.0	1.4	0.2	-0.1	0.4	-1.0	0.2
Tanning	0.0	0.4	0.9	-0.6	-0.6	-0.7	-0.1	-0.4	-1.0
Hand grip strength (left)	0.4	1.1	2.0	-0.1	-1.0	-1.1	1.0	-1.1	-1.4
Number of treatments/medications taken	0.7	1.3	2.1	-1.5	1.3	0.7	1.2	0.5	1.3
Average weekly spirits intake	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.1	0.1	-0.1
Sensitivity / hurt feelings	0.8	1.3	2.4	-0.6	0.9	0.7	1.5	1.3	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-1.0	0.9	1.3	-0.1	0.8	0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.7	0.6	-0.6	-0.8	0.7	0.5	-0.3
Relative age of first facial hair	0.3	0.7	2.3	-0.4	0.9	0.6	0.8	0.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.1	-0.9	0.5	-0.4	1.4	1.1	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.3	0.2	-0.2	-0.2	-0.5	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.5	-0.8	-0.4	-0.1	-1.0	-0.9
Systolic blood pressure, automated reading	0.2	0.6	2.2	0.8	-1.0	0.1	-0.5	1.5	-0.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.5	0.1	-1.6	-1.4	1.4	-1.3	-1.0
Angina	0.7	1.0	1.8	0.2	-1.3	-1.3	-0.5	-0.6	-1.3
Medication for hormone replacement therapy	1.1	1.2	2.2	1.5	-0.9	-1.2	0.4	-1.0	-1.2
Vitamin and mineral supplements	1.5	2.0	4.4	1.2	-1.3	-2.1	0.0	-1.4	-1.5
Supplements: Zinc	0.5	0.5	2.0	-0.8	0.1	1.4	-0.5	0.4	0.2
Medication: Co-codamol	1.3	1.5	3.7	1.2	-0.8	-0.4	-1.9	-1.0	-1.3
Medication: Metformin	0.9	1.3	3.2	0.2	-1.8	-0.4	-0.6	-1.1	-1.6
Diabetes (father)	2.2	2.7	10.9	3.3	-0.9	0.1	-1.3	-1.6	-0.6
Diabetes (mother)	0.3	0.3	1.1	-0.2	-0.4	-0.5	0.5	-1.1	-0.5
Severe depression (siblings)	0.1	0.1	0.2	-0.0	-0.4	-0.5	-0.4	-0.4	-0.3
Pack years adult smoking proportion	1.1	1.7	4.1	-1.0	-1.7	-0.8	-1.2	-0.5	-2.0
Impedance of leg (right)	0.2	1.0	3.6	0.3	1.3	0.1	-1.9	-0.2	0.9
Leg fat-free mass (left)	0.1	0.5	1.1	-0.5	-1.1	0.2	1.0	0.4	-0.7
Trunk fat percentage	0.1	0.3	1.2	-0.3	-0.4	0.4	-0.5	1.1	-0.2
Hand grip strength (right)	0.2	0.5	2.8	-0.2	0.1	0.0	1.7	-0.6	-0.1
Townsend deprivation index at recruitment	0.4	0.5	1.4	-1.2	-0.0	0.4	-0.2	1.2	0.5
Current tobacco smoking	0.8	1.2	2.9	-1.7	0.8	1.1	0.6	1.2	0.9
Average weekly fortified wine intake	0.2	0.3	0.9	-0.0	0.4	-0.0	0.4	-1.0	0.5
Maternal smoking around birth	0.2	0.3	1.3	-1.2	-0.2	-0.5	0.2	-0.3	0.2
Fed-up feelings	3.4	6.3	11.7	-0.5	2.0	3.4	2.1	2.9	3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	3.1	-1.7	1.4	1.6	-0.1	1.7	1.8
Relative age voice broke	0.2	0.3	0.9	0.7	-0.5	-0.0	0.1	-1.0	0.1
Taking other prescription medications	0.1	0.2	1.1	-1.0	0.1	0.1	-0.0	0.4	0.1
Age when periods started (menarche)	0.1	0.2	0.6	-0.8	0.1	-0.5	-0.2	-0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	6.5	-0.4	-1.7	-1.3	-0.4	-2.5	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.5	1.0	0.2	1.9	1.0	-0.3	0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	-0.5	-0.0	-1.1	-0.8	-1.4	-0.8
Qualifications: CSEs or equivalent	1.4	1.8	3.5	-1.3	1.7	1.9	-0.2	0.7	1.4
Serious illness, injury or assault to yourself	1.2	1.4	2.3	-1.5	0.9	1.0	0.7	1.3	1.5
High blood pressure	0.4	1.0	4.5	0.3	-0.9	0.5	-0.6	2.1	-0.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.6	0.0	2.1	0.2	-0.0	0.0	1.8
Multivitamins +/- minerals	1.7	2.2	3.6	-1.4	1.6	1.9	-0.2	1.2	1.8
Stomach or abdominal pain in last month	2.3	2.9	5.9	-1.6	1.6	2.2	0.1	2.4	1.4
Supplements: Glucosamine	0.1	0.2	0.3	-0.3	0.6	0.2	0.1	0.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.7	0.1	-0.0	0.4	-0.8	0.2	-0.0
Medication: Atenolol	0.2	0.3	0.9	-0.5	0.4	-0.2	0.0	1.0	0.4
Medication: Levothyroxine sodium	5.3	9.1	13.2	2.4	-3.4	-3.5	-1.8	-2.8	-3.6
Sitting height	0.1	0.5	1.0	0.0	-0.9	-0.2	0.3	-0.9	-1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	6.8	-2.6	0.1	0.4	0.3	0.1	0.3
High blood pressure (mother)	1.0	1.3	4.7	2.2	-0.1	0.4	1.1	1.3	0.7
Body mass index (BMI)	0.1	0.6	1.0	-1.0	-0.9	0.2	0.8	0.9	-0.7
Impedance of leg (left)	0.2	1.0	3.2	0.2	1.2	0.6	-1.8	-0.1	0.8
Leg predicted mass (left)	0.1	0.5	1.1	-0.6	-1.1	0.2	1.0	0.4	-0.7
Trunk fat mass	0.1	0.3	0.8	-0.7	-0.6	0.5	-0.1	0.9	-0.4
Waist circumference	0.1	0.2	0.5	-0.7	-0.5	0.0	0.0	0.5	-0.5
Number of incorrect matches in round	0.1	0.2	0.5	-0.5	-0.3	-0.2	0.7	-0.2	-0.5
Past tobacco smoking	0.8	1.4	2.2	1.5	1.4	1.2	-0.3	1.0	1.3
Alcohol usually taken with meals	0.4	0.7	2.2	-0.3	1.5	0.6	0.3	-0.3	1.1
Nervous feelings	0.8	1.5	4.9	0.3	0.9	0.8	0.4	2.2	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.8	-1.3	1.9	1.4	1.0	1.6	2.2
Hearing difficulty/problems with background noise	0.8	1.2	2.3	-1.2	1.0	-0.2	1.5	1.1	1.1
Hair/balding pattern: Pattern 2	1.8	2.3	4.1	-0.3	1.8	1.9	2.0	0.6	1.5
Had menopause	0.9	1.1	1.9	-0.6	1.2	0.7	0.8	1.4	1.4
Had other major operations	3.5	4.3	7.2	-2.2	2.7	1.9	1.2	1.2	2.6
Forced vital capacity (FVC)	0.3	1.1	3.6	-0.3	0.4	1.4	1.9	-0.3	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.0	0.9	0.3	2.0	1.0	-0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	0.2	-0.7	-1.2	-0.5	-1.0	-0.7
Qualifications: None of the above	0.2	0.5	1.2	-0.8	0.4	1.1	-0.7	0.1	0.6
Financial difficulties in last 2 years	0.3	0.4	1.0	0.2	-1.0	-0.5	-0.6	-0.4	-0.8
Mouth/teeth dental problems	0.7	1.0	2.7	0.5	1.7	-0.6	0.3	-0.3	1.6
Heart attack	0.2	0.3	0.7	-0.3	-0.7	-0.4	-0.6	-0.1	-0.8
Allergy	0.2	0.4	1.0	-0.5	-0.5	1.0	0.4	0.6	-0.3
Pain all over the body in last month	0.3	0.3	0.8	-0.0	0.9	-0.2	-0.1	0.5	0.9
Diabetes (self-reported)	0.6	1.0	3.2	0.3	-1.0	-0.8	-1.8	-0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.7	0.5	1.1	0.2	1.3	0.2	0.6
Medication: Ramipril	0.3	0.4	1.2	-1.1	-0.7	-0.2	0.5	0.0	-0.7
Medication: Simvastatin	2.5	3.6	7.1	1.0	-2.0	-2.7	-1.4	-2.0	-1.8
Fluid intelligence score	0.5	1.0	2.2	0.3	-0.5	-1.5	1.3	-1.2	-0.6
Illnesses of siblings	0.2	0.2	0.7	-0.4	0.6	-0.3	0.2	-0.8	0.4
Neuroticism score	3.4	7.0	13.5	-0.9	2.1	3.1	1.9	3.7	3.2
Weight	0.1	0.7	1.5	-1.2	-0.8	0.4	0.9	0.7	-0.6
Impedance of arm (right)	0.4	2.1	7.3	1.9	-0.0	-1.1	-2.7	-0.3	-0.1
Arm fat percentage (right)	0.2	0.8	2.2	0.0	-1.5	-0.6	-0.9	0.5	-1.1
Trunk fat-free mass	0.2	1.1	2.0	-1.2	-1.2	0.0	1.4	-0.7	-1.1
Hip circumference	0.1	0.5	1.0	-1.0	-0.8	0.3	0.9	0.5	-0.5
Time employed in main current job	0.5	0.6	2.6	0.6	-0.2	0.6	-0.0	1.6	0.3
Alcohol intake versus 10 years previously	0.5	0.7	2.2	-1.5	-0.1	1.1	0.9	0.5	0.3
Father’s age at death	0.9	1.3	3.1	0.0	1.8	-0.1	-1.4	-1.0	1.2
Worrier / anxious feelings	1.6	3.0	5.7	-0.2	1.6	2.0	0.8	2.4	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	7.5	-1.7	1.3	1.6	0.4	2.7	1.6
Falls in the last year	1.3	1.7	3.3	-1.3	1.8	1.0	-0.0	1.0	1.8
Hair/balding pattern: Pattern 3	1.1	1.7	3.6	-1.8	0.7	1.9	-0.3	1.4	1.0
Number of live births	0.3	0.4	0.9	0.6	-0.8	0.6	0.1	1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.3	0.3	-0.1	1.0	1.5	-0.2	0.3
Pulse rate	0.5	0.9	1.8	-1.3	-1.1	-0.6	0.3	-0.3	-1.3
Happiness	0.5	0.6	1.7	0.7	-1.0	-1.3	0.5	-0.3	-0.4
Noisy workplace	0.5	0.6	2.2	-1.5	0.4	0.0	-1.2	-0.0	-0.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.5	1.6	-0.9	-1.8	0.2	-2.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.4	-0.2	-0.1	0.2	1.2	0.1	0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	2.4	-1.5	-0.6	0.8	-0.6	-0.1	-0.7
Asthma	0.3	0.5	1.4	0.6	0.7	-1.2	-0.1	-0.7	0.7
Medication: Ibuprofen (e.g. Nurofen)	4.6	5.8	10.3	-3.2	3.0	2.4	1.4	1.4	2.5
Medication: Cholesterol lowering	0.7	1.0	3.6	0.0	-1.1	-1.9	-0.6	-0.5	-0.9
Depression (self-reported)	3.8	4.5	8.5	-1.8	2.9	2.0	0.3	1.9	2.7
Medication: Lansoprazole	1.5	1.7	8.2	-0.2	-0.3	-0.2	-2.9	-1.3	-0.6
Prospective memory result	0.7	0.9	2.1	-0.8	0.4	1.0	1.0	1.4	0.5
Lung cancer (father)	0.7	0.8	1.5	-1.2	1.2	1.0	0.5	-0.1	0.6
Illnesses of mother	1.6	1.9	3.8	-1.9	1.6	1.2	-0.6	1.0	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	0.2	0.2	0.4	1.2	-0.9	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.2	0.3	0.3	0.1	0.5	0.2
Impedance of arm (left)	0.3	1.2	5.5	1.2	0.3	-0.5	-2.4	-0.3	0.1
Arm fat mass (right)	0.1	0.6	1.6	-0.7	-1.3	-0.0	0.0	0.6	-0.9
Trunk predicted mass	0.2	1.0	1.8	-1.2	-1.1	0.0	1.4	-0.7	-1.0
Standing height	0.0	0.3	0.7	-0.8	0.3	0.6	0.6	-0.4	0.3
Length of working week for main job	1.0	1.1	5.1	0.2	-0.9	0.0	2.2	-0.2	-0.8
Exposure to tobacco smoke at home	0.7	0.8	2.0	-0.8	1.0	0.8	0.5	-0.4	1.4
Breastfed as a baby	0.2	0.2	0.7	0.2	-0.4	-0.8	0.5	-0.2	-0.4
Tense / ‘highly strung’	1.1	1.8	4.8	-1.2	1.4	0.3	0.9	2.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	-0.5	1.6	1.1	0.0	1.6	1.3
Hair/balding pattern: Pattern 4	0.1	0.4	1.3	0.2	0.2	-0.5	-1.2	-0.7	-0.0
Birth weight of first child	0.2	0.3	1.1	0.2	-0.4	-0.2	0.5	-1.0	-0.5
Peak expiratory flow (PEF)	0.3	0.8	2.1	0.8	-1.5	0.4	0.4	-0.7	-1.1
Pulse wave reflection index	0.1	0.1	0.4	0.1	0.3	0.2	-0.1	0.6	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.6	-0.8	-0.0	-0.1	-0.1	0.4	0.2
Loud music exposure frequency	2.9	3.1	5.9	2.2	-2.4	-1.2	-1.2	-0.7	-2.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	0.3	-0.4	-2.0	-1.1	-2.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.5	0.4	0.9	-0.6	0.8	0.7
Blood clot in the leg (DVT)	1.2	1.6	2.2	1.5	-0.8	-1.0	-1.5	-1.2	-1.5
Medication: Paracetamol	5.4	8.9	13.7	-3.1	3.7	3.4	1.7	1.9	3.5
Headache pain in last month	1.0	1.8	3.3	-1.0	1.7	0.9	-0.7	1.8	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.4	-0.8	1.0	1.6	0.4	0.4	0.8
Glaucoma (self-reported)	0.3	0.4	1.4	0.5	-0.1	0.1	1.2	-0.7	0.0
Gout (self-reported)	0.1	0.2	0.5	-0.2	-0.1	0.2	-0.7	-0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	3.3	6.5	9.7	2.1	-2.5	-2.4	-1.9	-3.0	-3.1
Medication: Amlodipine	0.3	0.4	0.6	-0.4	-0.8	0.8	-0.1	0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	0.4	0.5	-1.0	0.1	-0.0	0.2
Birth weight	0.3	0.6	1.9	1.4	-0.6	-0.4	-0.9	0.4	-0.2
Chronic bronchitis/emphysema (mother)	3.3	3.8	6.8	1.2	-2.4	-1.7	-2.0	-1.3	-2.6
High blood pressure (siblings)	0.3	0.5	1.6	0.8	-0.5	0.3	0.4	1.3	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.0	0.3	0.6	1.5	-1.0	0.5
Body fat percentage	0.1	0.4	0.7	-0.2	-0.7	0.1	-0.8	0.8	-0.6
Leg fat percentage (right)	0.1	0.4	1.0	-1.0	-0.2	0.4	-0.2	1.0	-0.2
Arm fat-free mass (right)	0.3	1.3	4.3	-1.5	-0.5	1.0	2.1	0.1	-0.3
Exposure to tobacco smoke outside home	1.5	2.0	2.6	-1.5	1.4	1.5	0.8	1.5	1.6
Comparative body size at age 10	0.1	0.4	0.8	0.1	-0.8	-0.7	-0.3	-0.4	-0.9
Number of full brothers	1.7	2.2	3.5	-1.9	0.8	1.7	-0.7	1.9	1.4
Worry too long after embarrassment	1.1	1.9	4.2	-0.6	1.3	1.0	-0.3	2.0	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	-0.9	1.3	0.5	0.1	1.8	1.2
Wheeze or whistling in the chest in last year	1.3	2.4	4.1	-1.6	2.0	0.9	0.8	1.6	1.9
Number of children fathered	0.1	0.1	0.2	-0.4	0.4	0.3	-0.1	0.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	3.0	-1.2	0.8	1.2	1.7	1.4	0.8
Age at first live birth	0.4	0.7	1.9	-0.2	1.0	0.7	1.4	-0.4	0.8
Pulse wave peak to peak time	0.0	0.0	0.2	0.0	-0.1	-0.1	0.1	-0.4	-0.0
Health satisfaction	0.4	0.5	1.2	-0.3	-1.1	-0.9	-0.0	-0.6	-0.8
Shortness of breath walking on level ground	4.6	5.5	8.6	1.4	-2.6	-2.9	-1.9	-2.1	-2.7
Qualifications: College or University degree	0.3	0.8	1.3	1.1	-0.8	-1.1	1.1	-0.1	-0.7
Eye problems/disorders: None of the above	1.0	1.1	3.3	-1.8	1.1	0.6	-0.4	0.9	1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	6.6	-1.1	-0.2	0.7	0.2	2.6	0.5
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.8	0.4	0.7	0.4	0.3	0.4
Medication for pain relief, constipation, heartburn	6.3	10.7	13.6	3.6	-3.7	-3.4	-2.6	-2.5	-3.6
Neck or shoulder pain in last month	2.7	3.9	5.3	-2.0	2.2	2.1	-0.6	2.1	2.3
Medication: Blood pressure	0.1	0.2	0.6	0.4	-0.3	-0.8	0.1	0.2	-0.3
Angina (self-reported)	0.6	0.8	1.6	0.2	-1.2	-1.3	-0.2	-0.6	-1.2
Migraine (self-reported)	1.3	1.6	4.2	-0.4	1.1	0.8	-1.2	2.1	1.2
Medication: Ibuprofen	4.5	5.4	9.6	-2.9	3.1	2.1	1.4	1.0	2.7
Medication: Allopurinol	0.4	0.5	1.7	-1.3	0.7	0.6	-0.2	-0.7	0.2
Medication: Omeprazole	0.5	0.5	2.1	0.2	-0.8	0.6	1.4	0.1	-0.4
Medication: Seretide 50 evohaler	0.5	0.6	2.8	-0.4	0.3	0.5	-1.7	0.3	0.2
Mean time to correctly identify matches	0.1	0.3	0.7	0.7	-0.0	0.4	-0.8	0.2	0.4
Heart disease (mother)	3.5	4.2	8.9	-1.4	2.3	1.4	0.9	3.0	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	0.3	0.9	1.4	0.6	0.4	1.1
Whole body fat mass	0.1	0.4	1.0	-0.6	-0.7	0.3	-0.0	1.0	-0.5
Leg fat mass (right)	0.1	0.4	1.0	-1.0	-0.6	0.3	0.1	0.9	-0.5
Arm predicted mass (right)	0.2	1.2	3.2	-1.5	-0.6	0.8	1.8	-0.1	-0.5
Pulse rate, automated reading	0.4	1.3	3.4	0.3	-1.9	-1.2	0.4	-0.7	-1.5
Alcohol intake frequency.	0.1	0.3	1.0	-0.1	-0.7	-0.3	-0.5	-0.2	-1.0
Comparative height size at age 10	0.8	4.5	7.5	-2.4	2.2	2.7	2.1	1.0	1.8
Number of full sisters	0.5	0.7	1.6	0.3	-0.7	1.2	1.2	0.4	-0.5
Suffer from ‘nerves’	1.1	1.7	3.5	-0.5	0.9	1.9	-0.6	1.8	1.4
Overall health rating	1.6	3.5	6.6	-2.6	1.7	2.0	0.4	1.7	2.1
Chest pain or discomfort	0.4	0.6	1.7	0.3	-1.1	-0.6	0.1	0.1	-1.3
Had major operations	0.3	0.4	0.8	0.0	0.6	0.0	0.7	0.7	0.9
Age at last live birth	0.7	1.0	3.5	-0.9	0.7	0.7	1.9	0.5	0.7
Family relationship satisfaction	0.5	0.6	2.0	-1.0	0.2	-0.4	1.4	0.7	0.2
Leg pain on walking	1.0	1.3	2.6	1.2	-0.4	-1.0	-1.6	-1.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.2	-0.9	1.3	1.5	0.6	1.8	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	0.9	-0.9	0.2	-0.5	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	0.9	-0.3	-1.2	-0.8	-1.0	-0.7
Medication: Aspirin	0.1	0.1	0.3	0.2	-0.4	-0.1	-0.5	0.5	0.3
Supplements: Vitamin C	0.7	0.8	1.5	-0.7	0.7	0.8	1.2	1.1	0.7
Knee pain experienced in last month	0.8	1.3	3.8	-1.0	0.7	1.9	0.7	1.1	0.8
Hypertension (Self-reported)	0.4	1.2	5.5	0.2	-0.7	0.9	-0.4	2.4	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	5.7	-0.9	-2.2	-0.3	-1.8	-1.9	-2.4
Illnesses of father: Heart disease	0.5	0.7	1.4	0.5	-1.2	-0.7	0.5	0.9	-0.8
Illnesses of siblings: Diabetes	1.0	1.3	2.8	0.6	-0.9	-1.0	-1.7	-1.3	-1.0
Smoking status: Previous	0.6	0.9	3.1	-1.8	-0.9	-0.6	0.3	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	0.2	-0.2	0.1	0.5	-0.5	0.0
Whole body fat-free mass	0.1	0.8	1.8	-1.0	-1.1	0.2	1.4	-0.1	-0.8
Leg fat-free mass (right)	0.1	0.7	1.7	-0.6	-1.0	0.4	1.3	0.3	-0.7
Arm fat percentage (left)	0.1	0.6	1.4	-0.3	-1.2	-0.2	-0.8	0.6	-0.9
Average weekly red wine intake	0.3	0.4	2.0	0.0	-0.5	-0.1	1.4	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	2.1	2.6	4.6	1.4	-1.5	-1.7	-1.2	-2.1	-1.6
Mood swings	1.3	2.4	5.7	-0.8	0.8	1.4	1.6	2.4	1.7
Loneliness, isolation	0.1	0.1	0.7	-0.1	-0.3	0.2	0.8	0.2	-0.1
Long-standing illness, disability or infirmity	0.2	0.4	2.0	-1.4	-0.2	0.1	-0.4	-0.1	-0.1
Ever had bowel cancer screening	1.2	1.4	2.6	-0.6	1.6	0.9	-0.5	1.4	1.5
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.6	-0.9	-0.9	-1.3	-1.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.9	-0.2	0.6	0.9	0.2	-0.6
Friendships satisfaction	0.5	0.6	1.4	0.5	-1.0	-1.2	-0.8	-0.2	-0.6
Qualifications: nursing, teaching	0.5	0.8	2.7	0.5	-0.1	-1.0	1.0	-1.7	-0.2
Commuting to job workplace: Walk	2.6	2.8	6.7	-0.6	2.2	1.2	1.3	1.4	2.6
Eye problems/disorders: Cataract	1.9	2.2	4.1	1.4	-1.4	-1.1	-0.9	-2.0	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	6.8	1.0	-2.5	-0.6	0.7	-1.2	-2.6
Medication for cholesterol	0.4	0.6	1.5	-1.2	1.1	0.5	-0.2	-0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.6	6.9	-2.2	2.6	1.9	0.7	0.6	2.4
Back pain experienced in last month	0.4	0.6	2.9	-0.6	-0.2	0.4	-1.7	0.1	-0.5
Mineral and other dietary supplements	0.2	0.2	1.0	0.5	0.2	-0.3	0.2	-1.0	-0.2
Breast cancer (self-reported)	1.2	1.5	3.4	0.6	-1.2	-1.8	1.8	-0.1	-0.7
Asthma (self-reported)	0.2	0.5	1.3	0.3	0.6	-1.2	0.0	-0.8	0.6
Osteoporosis (self-reported)	1.0	1.3	2.3	-1.5	-0.8	-0.6	-1.1	1.4	-1.1
Osteoarthritis (self-reported)	0.4	0.6	1.8	-1.3	0.4	0.6	-0.6	0.8	0.3
Medication: Aspirin	0.2	0.2	0.6	0.2	-0.3	0.3	-0.6	0.8	0.5
Medication: Gliclazide	0.4	0.4	2.2	-0.6	-0.3	-0.3	-0.0	-1.5	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.4	-0.3	-0.1
Smoking status: Current	0.8	1.3	3.5	-1.9	0.9	1.1	0.5	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.0	0.1	-0.4	-0.2	0.2	-1.0	-0.2
Whole body water mass	0.2	0.9	1.7	-1.0	-1.2	0.1	1.3	-0.3	-1.0
Leg predicted mass (right)	0.1	0.6	1.4	-0.6	-1.0	0.4	1.2	0.4	-0.7
Arm fat mass (left)	0.2	0.6	1.4	-1.2	-1.1	0.2	0.4	0.7	-0.8
Number of self-reported non-cancer illnesses	1.2	2.1	4.7	-0.8	2.2	1.5	0.4	1.4	1.7
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.2	-0.4	-0.9	-0.6	-1.1	-0.4
Miserableness	0.2	0.4	1.5	0.5	-0.1	0.6	0.1	-1.2	0.3
Guilty feelings	2.4	3.6	7.3	-0.9	1.9	2.4	1.2	1.6	2.7
Wears glasses or contact lenses	1.1	1.2	3.1	-0.5	1.3	1.2	-0.1	1.0	1.8
Ever taken oral contraceptive pill	1.0	1.1	1.8	1.2	-1.3	-0.9	-1.4	-0.3	-0.8
Hearing aid user	0.7	0.8	4.0	-0.2	0.1	0.3	2.0	-0.6	0.5
Mother’s age at death	0.2	0.3	0.7	0.7	-0.2	-0.9	-0.5	-0.4	0.1
Financial situation satisfaction	0.1	0.2	0.5	0.7	0.3	0.1	0.4	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	1.1	-0.4	-0.9	-0.4	-0.8	-0.0
Commuting to job workplace: Public transport	1.6	1.9	7.3	0.7	1.0	-1.4	-2.7	-0.7	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	1.0	-0.7	-0.2	0.2	-0.6	-0.7
Medication: Blood pressure	0.2	0.4	1.5	0.5	-0.7	0.2	-0.6	1.2	-0.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.3	-1.5	1.4	0.8	-0.7	1.4	1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	-1.0	-0.1	0.9	0.3	1.7	0.6
High cholesterol (Self-reported)	1.6	2.9	4.8	-0.5	-1.8	-2.2	-0.8	-2.0	-2.0
Medication: Bendroflumethiazide	0.7	1.0	2.3	1.1	0.9	-0.3	-0.2	1.2	1.5
Medication: Paracetamol	6.1	9.4	16.4	-3.2	4.1	3.5	1.3	1.6	3.7
Medication: Lisinopril	0.5	0.6	2.1	1.4	-0.5	-0.2	-0.1	1.1	0.1
Medication: Atorvastatin	0.3	0.4	0.7	0.4	-0.8	-0.6	0.2	-0.8	-0.8
Illnesses of father: High blood pressure	0.7	0.9	2.2	0.5	1.5	0.7	0.4	0.6	1.4
Alcohol drinker status: Never	1.2	1.4	2.3	0.8	-0.8	-1.5	-1.2	-1.5	-1.0
Ever smoked	0.9	1.6	2.9	-0.7	-1.7	-1.4	0.9	-1.0	-1.6
Basal metabolic rate	0.1	0.8	1.6	-1.2	-1.1	0.3	1.2	0.0	-0.8
Leg fat percentage (left)	0.1	0.5	1.4	-1.0	-0.3	0.8	-0.1	1.2	-0.2
Arm fat-free mass (left)	0.2	1.2	3.3	-1.5	-0.8	0.8	1.8	0.2	-0.6
Number of operations (self-reported)	6.5	9.7	14.5	-2.1	3.6	3.3	2.4	3.1	3.8
Average weekly beer plus cider intake	4.7	6.8	10.7	-3.3	2.3	3.1	1.5	2.6	2.4
Irritability	0.4	0.7	3.0	0.1	-0.3	0.2	-0.9	1.7	0.5
Risk taking	0.5	0.7	2.1	-1.5	0.4	0.3	1.2	0.4	0.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.2	-0.2	0.1	-1.1	0.6	-0.9	0.3
Fractured/broken bones in last 5 years	0.3	0.3	1.8	-1.3	0.1	0.4	-0.2	0.2	0.1
Age started oral contraceptive pill	1.0	1.3	3.3	-0.6	1.6	0.5	0.0	1.1	1.8
Diastolic blood pressure, automated reading	0.3	1.0	5.7	-0.2	-0.1	0.6	-0.2	2.4	0.3
Ever depressed for a whole week	0.6	0.7	1.4	-0.2	1.2	0.3	0.8	0.9	1.1
Unable to work because of sickness or disability	0.4	0.6	2.3	-1.5	0.5	0.1	-0.4	0.5	0.6
Commuting to job workplace: Cycle	2.5	3.0	5.0	2.2	-1.6	-1.6	0.6	-2.1	-1.8
Myopia	1.7	2.4	3.8	-1.5	1.9	1.8	0.9	0.9	1.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	5.1	-0.2	0.4	-0.5	0.9	-2.2	-0.3
Cholesterol lowering medication	1.7	2.5	4.0	1.4	-2.0	-1.3	-1.1	-1.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.1	-0.1	-0.0	0.8	1.4	0.8	0.0
Pain experienced in last month	5.1	8.5	13.8	2.1	-3.2	-3.2	-0.2	-3.7	-3.5
Supplements: Calcium	0.8	0.9	2.3	-1.5	0.6	1.1	0.7	0.7	0.7
Basal cell carcinoma (self-reported)	0.2	0.3	1.5	0.0	0.2	-0.0	0.4	-1.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.0	-0.9	-0.3	-0.9	-0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.6	1.3	-0.7	-0.9	-1.6	-0.7	-1.2
Heart disease (siblings)	0.2	0.2	0.4	-0.6	-0.3	-0.1	0.5	0.6	0.3
Alcohol drinker status: Previous	0.8	1.0	2.7	0.4	-1.2	0.1	-1.6	0.4	-1.1
Pack years of smoking	1.2	1.8	3.9	-0.9	-1.6	-1.0	-1.5	-0.6	-2.0
Impedance of whole body	0.2	1.2	4.1	1.0	1.1	0.1	-2.0	-0.1	0.8
Leg fat mass (left)	0.1	0.5	0.9	-0.9	-0.7	0.5	0.2	0.9	-0.6
Arm predicted mass (left)	0.3	1.3	4.8	-1.4	-0.7	0.7	2.2	0.0	-0.4