TWAS hub - BRD7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Male)	0.0126	0.0705	4.5e-01	-0.008	NA	-0.012	NA	-0.013	5.3e-01	NA	8.0e-01	NA	1.0e+00
2	GTEx	Breast Mammary Tissue (Female)	0.1295	0.0666	3.1e-02	-0.006	NA	-0.004	NA	-0.010	5.1e-01	NA	4.4e-01	NA	8.9e-01
3	GTEx	Whole Blood	0.1580	0.0410	7.6e-06	0.125	NA	0.119	NA	0.118	1.3e-11	NA	4.2e-11	NA	5.3e-11
4	METSIM	Adipose	0.0591	0.0217	5.5e-04	0.049	0.017	0.038	0.032	0.047	7.6e-08	1.1e-03	1.7e-06	1.2e-05	1.1e-07
5	YFS	Blood	0.1806	0.0259	0.0e+00	0.174	0.160	0.176	0.186	0.185	1.6e-54	5.8e-50	4.6e-55	1.8e-58	4.1e-58

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5
Hypothyroidism (self reported)	11.9	27.4	40.0	-5.3	-6.0	-5.7	-6.3
Hypothyroidism/myxoedema (self-reported)	9.1	17.8	28.1	-4.2	-4.9	-4.4	-5.3
Medication: Levothyroxine sodium	8.7	14.7	25.7	-3.8	-4.4	-3.7	-5.1
Irritable Bowel Disease (IBD)	8.5	20.2	38.4	1.4	-6.2	-6.2	-4.7
Crohns Disease (2017)	8.1	17.8	38.5	2.3	-6.2	-5.6	-3.6
Ulcerative Colitis	7.9	11.5	20.6	-0.3	-4.1	-4.5	-4.4
Mouth/teeth dental problems: Mouth ulcers	7.1	11.3	19.2	-2.2	-3.8	-4.2	-4.4
Crohns Disease (2012)	7.0	11.3	26.0	1.6	-5.1	-4.3	-3.1
Shortness of breath walking on level ground	5.7	6.7	9.9	-2.9	-2.5	-3.0	-3.1
Ulcerative Colitis (UC)	4.6	8.6	17.9	0.5	-3.5	-4.2	-3.5
Tinnitus: Yes, but not now, but have in the past	4.5	4.8	7.9	-1.7	-2.7	-2.8	-2.4
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	9.6	-0.7	-2.6	-2.9	-3.1
Medication: Co-codamol	3.8	4.4	7.0	-2.1	-2.6	-2.0	-2.6
Exposure to tobacco smoke outside home	3.6	4.8	8.6	2.4	-2.2	-2.9	-2.1
Frequency of depressed mood in last 2 weeks	3.5	5.0	8.8	1.3	3.0	2.5	2.8
Depression (Nagel 2018)	3.2	4.8	10.4	1.2	3.2	1.9	2.9
Leg pain on walking	2.6	3.3	5.2	-1.9	-1.8	-2.3	-2.1
Back pain experienced in last month	2.5	3.6	5.9	-1.1	-2.4	-2.4	-2.3
Mean Putamen Volume	2.3	2.6	4.5	0.7	-2.1	-2.1	-2.0
Lupus	2.2	3.4	7.4	-1.8	-1.9	-1.5	-2.7
Primary Biliary Cirrhosis	2.2	3.1	5.9	0.2	-2.1	-2.4	-2.3
Happiness	2.1	2.5	5.0	-0.7	2.1	2.2	1.6
Qualifications: College or University degree	2.1	6.5	12.2	0.7	3.3	3.5	3.0
Diabetes (father)	2.0	2.5	4.7	-0.6	2.2	2.0	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	6.1	0.8	2.5	1.6	2.1
Blood clot in the leg (DVT)	2.0	2.5	7.3	-2.7	-1.1	-1.6	-1.3
Medication: Gliclazide	2.0	2.2	3.4	1.2	1.8	1.7	1.8
Coronary Artery Disease (CAD)	1.9	2.3	5.7	-2.4	-1.5	-1.0	-1.6
Smoking Status	1.9	4.5	8.4	1.2	-2.5	-2.9	-2.5
Health satisfaction	1.9	2.5	4.9	-0.7	-1.7	-2.1	-2.2
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	6.6	0.9	1.7	2.6	1.3
Long-standing illness, disability or infirmity	1.8	2.8	5.1	-1.0	-1.8	-2.3	-2.2
Alzheimer’s Disease (in mother)	1.7	2.0	3.9	-1.7	-1.5	-1.1	-2.0
Type 2 Diabetes (T2D) (2012)	1.7	1.9	7.7	2.8	-1.1	-0.8	-0.2
Asthma (self-reported)	1.7	3.3	5.1	-2.2	-1.9	-2.0	-2.0
Supplements: Zinc	1.6	1.7	2.5	-1.5	1.6	1.6	1.2
Asthma	1.6	3.2	4.3	-2.0	-1.9	-2.1	-2.1
Pulse wave Arterial Stiffness index	1.6	1.9	3.5	-0.5	-1.6	-1.8	-1.9
Alzheimer’s Disease (including proxy)	1.5	2.2	3.9	-1.8	-1.6	-1.2	-2.0
Pack years adult smoking proportion	1.5	2.3	4.0	-0.7	-2.0	-1.7	-2.0
Neuroticism score	1.5	3.0	5.9	1.3	2.4	2.1	1.7
Breastfed as a baby	1.5	1.9	3.3	0.2	1.8	1.8	1.7
Smoking status: Current	1.5	2.4	4.5	0.2	-2.1	-1.9	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	5.1	-2.3	-1.0	-1.5	-1.1
Serious illness, injury or assault to yourself	1.4	1.7	3.1	0.8	-1.5	-1.7	-1.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.6	-0.6	1.6	1.4	1.9
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.0	-0.9	-1.7	-1.7	-1.3
Exposure to tobacco smoke at home	1.3	1.5	2.3	1.5	-1.5	-1.5	-0.8
Birth weight	1.3	2.8	5.1	1.8	2.0	1.4	2.3
Eye problems/disorders: None of the above	1.3	1.5	3.5	1.9	-1.4	-1.3	-0.8
Handedness (chirality/laterality): Left-handed	1.3	1.6	7.0	-2.6	-0.1	0.6	-0.8
Ever depressed for a whole week	1.3	1.5	2.6	1.1	1.6	1.3	1.5
Pack years of smoking	1.3	1.9	3.5	-0.6	-1.9	-1.7	-1.8
Schizophrenia (2018)	1.2	2.4	10.9	3.3	-0.7	-0.8	-0.4
Schizophrenia vs Biploar Disorder	1.2	1.5	6.8	2.6	-0.5	-0.4	-0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.3	0.1	1.5	1.5	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.7	-1.3	2.2	2.0	1.7
Alcohol intake versus 10 years previously	1.2	1.9	3.7	1.3	-1.5	-1.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.6	0.2	-1.6	-1.4	-1.6
Friendships satisfaction	1.2	1.4	3.6	-0.3	1.5	1.9	1.1
Mineral and other dietary supplements	1.2	1.6	3.3	0.4	1.5	1.6	1.8
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.2	1.4	-1.3	-1.3	-1.5
Worry (Nagel 2018)	1.1	2.3	4.1	1.5	2.0	1.7	1.6
Ovarian Cancer	1.1	1.4	2.4	0.9	1.5	1.5	1.4
Neuroticism (2016)	1.1	1.6	2.8	1.1	1.7	1.3	1.5
Hand grip strength (left)	1.1	2.8	5.0	0.1	-2.2	-2.2	-2.1
High blood pressure (mother)	1.1	1.6	3.8	1.9	1.2	1.4	0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.0	0.8	1.4	1.2	1.7
Glaucoma (self-reported)	1.1	1.3	3.4	-0.1	1.3	1.9	1.3
Medication: Aspirin	1.1	1.4	3.0	-0.2	1.4	1.3	1.7
Prostate Cancer	1.0	1.4	2.4	-1.6	1.4	1.4	0.6
Current tobacco smoking	1.0	1.6	2.8	0.3	-1.7	-1.6	-1.6
Supplements: Glucosamine	1.0	1.4	3.1	-0.0	-1.3	-1.4	-1.8
Alcohol usually taken with meals	1.0	1.6	2.5	-1.1	1.4	1.5	1.6
Fluid intelligence score	1.0	2.0	3.6	1.7	1.2	1.4	1.9
Father’s age at death	1.0	1.4	2.9	-0.2	1.3	1.5	1.7
Number of live births	1.0	1.3	2.3	-1.2	-1.3	-1.2	-1.5
Pulse wave peak to peak time	1.0	1.2	2.3	0.4	1.2	1.5	1.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.3	2.3	0.7	0.2	0.6
Heart disease (mother)	1.0	1.2	2.0	1.3	1.3	0.8	1.4
Suffer from ‘nerves’	1.0	1.6	3.6	0.1	1.9	1.5	1.5
Qualifications: nursing, teaching	1.0	1.5	4.1	-2.0	-1.2	-0.5	-1.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.7	0.0	1.3	1.6	1.2
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	0.4	-1.4	-1.5	-1.2
Pain all over the body in last month	0.9	0.9	1.8	-1.3	-0.7	-0.7	-1.3
Medication: Cholesterol lowering	0.9	1.4	2.2	-0.9	1.5	1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.6	1.5	1.6	1.6	1.6
Number of self-reported non-cancer illnesses	0.9	1.6	3.3	-0.6	-1.1	-1.7	-1.8
Neuroticism (Nagel 2018)	0.8	1.8	3.0	1.5	1.7	1.2	1.4
Blood White Count	0.8	5.6	10.6	1.9	3.3	2.8	2.4
Allergy or Eczema	0.8	2.1	3.3	1.8	1.3	1.7	1.5
Neuroticism	0.8	1.8	2.7	1.6	1.6	1.6	1.1
Fed-up feelings	0.8	1.4	3.3	1.8	1.4	1.1	0.7
Medication: Atenolol	0.8	1.0	3.1	1.8	0.6	0.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.3	-1.0	1.8	1.7	1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.8	-1.7	1.0	0.3	0.9
Birth weight of first child	0.8	1.4	2.3	1.1	1.2	1.4	1.5
Peak expiratory flow (PEF)	0.8	1.8	3.2	1.8	1.1	1.8	1.3
Medication: Amlodipine	0.8	1.2	5.5	2.4	0.3	-0.4	0.4
Mother’s age at death	0.8	1.0	1.9	1.2	0.7	1.4	1.1
Medication: Bendroflumethiazide	0.8	1.1	2.0	1.4	-1.3	-1.0	-1.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.2	-0.5	-1.5	-0.7	-1.3
Alzheimer’s Disease (in father)	0.7	0.7	1.2	-0.8	-1.1	-1.0	-1.0
Lung FVC	0.7	3.7	12.0	3.5	1.4	1.2	1.7
Number of treatments/medications taken	0.7	1.3	2.3	-0.5	-1.2	-1.5	-1.5
Taking other prescription medications	0.7	1.1	2.0	-1.4	-0.6	-1.2	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	1.0	4.2	2.1	-0.0	0.7	0.3
Illnesses of mother	0.7	0.9	1.6	0.8	-1.2	-1.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	-0.7	-1.0	-1.2	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.1	4.4	-2.1	-0.6	-0.6	-0.7
Average weekly red wine intake	0.7	1.0	1.8	-1.3	1.3	1.1	0.6
Eye problems/disorders: Cataract	0.7	0.8	2.4	-1.5	0.7	1.0	0.5
Miserableness	0.7	1.2	2.0	-1.4	1.3	1.1	1.1
High cholesterol (Self-reported)	0.7	1.3	6.1	-2.5	-0.3	-0.1	-0.6
Depressed Affect (Nagel 2018)	0.6	1.3	3.2	0.5	1.8	1.4	1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.5	1.6	1.1	0.8	1.6
Age at First Birth	0.6	0.9	2.0	-1.4	-0.9	-0.7	-1.1
HbA1C	0.6	0.7	1.6	0.2	0.9	1.3	1.1
Schizophrenia (2014)	0.6	1.2	6.0	2.4	0.1	-0.3	0.2
Respiratory disease	0.6	1.4	2.8	-1.3	-1.1	-1.1	-1.7
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-1.3	1.2	1.0	0.5
Medication for hormone replacement therapy	0.6	0.7	1.2	-0.4	1.1	0.9	1.1
Hand grip strength (right)	0.6	1.7	3.5	0.2	-1.9	-1.8	-1.3
Body mass index (BMI)	0.6	2.4	9.8	3.1	1.0	0.6	0.8
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	0.8	1.1	1.0	0.9
Had menopause	0.6	0.7	1.2	0.9	-1.1	-0.9	-1.0
Prospective memory result	0.6	0.7	1.7	-0.4	-1.1	-0.6	-1.3
Standing height	0.6	5.7	10.4	-2.0	-3.2	-2.4	-2.9
Hair/balding pattern: Pattern 4	0.6	1.5	4.4	0.4	-1.5	-2.1	-0.8
Guilty feelings	0.6	0.9	1.3	1.1	1.0	1.0	1.0
Commuting to job workplace: Public transport	0.6	0.7	2.6	-1.6	0.3	-0.2	0.7
Irritability	0.6	1.1	2.8	0.5	1.7	0.8	1.2
Risk taking	0.6	0.8	1.1	0.9	1.1	1.1	1.0
Age started oral contraceptive pill	0.6	0.7	3.6	1.9	-0.4	-0.0	0.0
Height	0.5	10.0	15.4	-3.4	-3.9	-3.4	-3.4
Relative age voice broke	0.5	0.8	1.2	-1.1	1.0	1.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.9	-1.7	0.3	0.2	-0.3
Worrier / anxious feelings	0.5	0.9	1.5	0.7	1.2	1.1	1.1
Leg fat percentage (right)	0.5	1.7	7.8	2.8	0.5	0.1	0.7
Medication: Aspirin	0.5	0.7	1.6	-0.3	0.9	0.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.0	-0.7	-1.4	-1.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.9	-0.7	-0.6	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	-0.1	-0.8	-1.2	-0.9
Wears glasses or contact lenses	0.5	0.5	1.0	0.5	1.0	1.0	0.8
Medication: Blood pressure	0.5	1.0	3.3	1.8	-0.9	-0.7	-0.7
Leg fat percentage (left)	0.5	1.7	8.2	2.9	-0.1	-0.2	0.3
Average weekly beer plus cider intake	0.5	0.7	1.4	1.2	-0.9	-0.9	-0.7
Myopia	0.5	0.8	1.5	-0.3	1.1	1.1	1.2
Supplements: Calcium	0.5	0.5	0.8	-0.9	0.9	0.6	0.7
Alcohol drinker status: Previous	0.5	0.5	1.0	0.7	1.0	0.3	1.0
Bipolar Disorder (2018)	0.4	0.7	3.0	-1.7	-0.0	-0.5	0.2
Triglycerides	0.4	0.7	1.7	0.0	-1.2	-1.3	-0.7
BMI	0.4	2.1	10.2	3.2	0.4	0.3	0.0
Angina	0.4	0.5	1.5	-0.1	0.9	0.4	1.2
Medication: Metformin	0.4	0.5	1.4	0.4	0.7	1.2	0.7
Diabetes (mother)	0.4	0.6	1.0	-1.0	-0.9	-0.7	-0.8
Trunk fat percentage	0.4	1.7	6.1	2.5	-1.0	-1.1	-0.4
Townsend deprivation index at recruitment	0.4	0.6	2.3	1.5	0.4	0.2	0.5
Maternal smoking around birth	0.4	0.5	0.8	-0.8	-0.6	-0.8	-0.9
High blood pressure	0.4	1.0	1.9	1.0	-1.2	-0.9	-1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	0.9	0.9	1.0	1.1
Trunk fat mass	0.4	1.6	5.3	2.3	-1.1	-1.1	-0.7
Nervous feelings	0.4	0.7	2.0	0.4	1.4	0.8	0.9
Allergy	0.4	0.9	2.1	1.4	0.8	0.9	0.8
Arm fat percentage (right)	0.4	1.5	7.2	2.7	-0.1	-0.4	0.0
Time employed in main current job	0.4	0.5	1.5	1.2	-0.6	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.4	1.8	0.6	1.2	0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.3	-1.2	0.6	1.5	0.5
Impedance of arm (left)	0.4	1.7	3.7	-1.0	-1.9	-1.8	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-1.0	-0.6	-0.8	-0.3
High blood pressure (siblings)	0.4	0.6	2.9	1.7	0.3	0.2	-0.3
Body fat percentage	0.4	1.5	6.5	2.5	-0.5	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	1.2	0.7	0.2	0.8
Number of children fathered	0.4	0.5	1.0	1.0	0.9	0.5	0.7
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.3	0.9	0.7	1.0
Medication: Ibuprofen	0.4	0.5	2.2	1.5	-0.4	0.0	-0.1
Medication: Seretide 50 evohaler	0.4	0.5	2.0	-1.4	-0.3	-0.5	-0.3
Whole body fat mass	0.4	1.5	6.9	2.6	-0.6	-0.6	-0.3
Leg fat mass (right)	0.4	1.4	6.7	2.6	0.1	-0.2	0.1
Overall health rating	0.4	0.9	2.4	0.8	-0.6	-1.5	-1.1
Family relationship satisfaction	0.4	0.5	1.5	0.1	0.9	1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	1.3	0.2	0.7	0.5
Hypertension (Self-reported)	0.4	1.0	2.9	1.7	-0.9	-0.6	-1.1
Arm fat percentage (left)	0.4	1.6	7.7	2.8	-0.2	-0.5	-0.1
Mood swings	0.4	0.7	1.9	0.6	1.4	0.8	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.2	0.1	-0.6	-1.1	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	1.2	-0.1	0.8	0.7
Commuting to job workplace: Cycle	0.4	0.5	2.3	-1.5	-0.3	-0.3	-0.4
Leg fat mass (left)	0.4	1.4	6.8	2.6	-0.3	-0.5	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	2.3	1.5	-0.5	-0.9	-0.2
Breast Cancer	0.3	0.7	1.9	0.1	0.8	0.8	1.4
Multivitamins +/- minerals	0.3	0.4	0.9	-0.1	1.0	0.6	0.9
Sitting height	0.3	2.5	3.5	-1.9	-1.8	-1.6	-1.8
Chronic bronchitis/emphysema (father)	0.3	0.4	1.5	-1.2	-0.1	-0.2	-0.6
Waist circumference	0.3	1.2	6.1	2.5	-0.0	-0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	0.7	1.0	0.5	0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.1	-0.8	1.1	0.7	0.6
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.4	-0.5	-0.7	-1.0
Heart attack	0.3	0.4	0.7	0.5	-0.7	-0.9	-0.8
Medication: Simvastatin	0.3	0.5	1.6	-1.3	0.6	-0.2	0.6
Illnesses of siblings	0.3	0.4	1.3	-1.1	-0.7	-0.4	-0.1
Impedance of arm (right)	0.3	1.6	3.0	-1.2	-1.7	-1.6	-0.8
Hip circumference	0.3	1.4	6.9	2.6	-0.3	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.6	-0.3	-0.3	-1.3	-0.6
Depression (self-reported)	0.3	0.4	1.3	-1.1	0.4	-0.5	0.3
Arm fat mass (right)	0.3	1.3	6.1	2.5	-0.2	-0.3	-0.2
Tense / ‘highly strung’	0.3	0.5	2.2	1.5	0.4	0.1	0.2
Comparative body size at age 10	0.3	0.7	1.3	1.1	-0.5	-1.0	-0.9
Number of full brothers	0.3	0.3	0.7	0.8	-0.4	-0.8	-0.4
Age at first live birth	0.3	0.6	1.1	0.5	0.7	1.0	1.0
Neck or shoulder pain in last month	0.3	0.4	1.3	0.8	-0.5	-1.2	-0.0
Angina (self-reported)	0.3	0.4	1.1	-0.4	0.8	0.3	1.1
Migraine (self-reported)	0.3	0.3	0.6	0.7	0.7	0.4	0.8
Mean time to correctly identify matches	0.3	0.5	1.1	1.0	0.7	0.8	0.5
Number of full sisters	0.3	0.3	0.6	0.2	-0.6	-0.8	-0.7
Chest pain or discomfort	0.3	0.4	1.1	-1.0	0.0	-0.8	-0.4
Loneliness, isolation	0.3	0.5	1.0	-0.5	1.0	1.0	0.2
Medication for cholesterol	0.3	0.4	1.4	-1.2	0.6	0.3	0.2
Breast cancer (self-reported)	0.3	0.3	0.8	-0.9	-0.3	0.0	-0.8
Arm fat mass (left)	0.3	1.4	6.9	2.6	-0.2	-0.4	-0.3
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.1	-0.9	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.8	-0.6	-0.3	-0.5
Diastolic blood pressure, automated reading	0.3	0.8	3.5	1.9	0.3	0.6	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	-0.8	1.0	1.0	1.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-1.0	0.5	0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.3	-0.6	-0.9	-0.7
Impedance of whole body	0.3	1.5	3.1	-1.4	-1.8	-1.4	-0.4
Reaction Time	0.2	0.3	1.1	1.1	0.3	0.5	0.3
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.8	-0.4	-0.4	-0.5
Blood Platelet Count	0.2	2.9	5.8	1.8	2.4	1.5	1.8
Chronotype (morning person)	0.2	0.4	1.4	-1.2	-0.0	0.7	0.1
Average weekly spirits intake	0.2	0.3	0.6	-0.4	0.8	0.7	0.4
Sensitivity / hurt feelings	0.2	0.3	0.7	0.9	0.6	0.6	0.3
Systolic blood pressure, automated reading	0.2	0.7	2.1	1.4	0.7	0.8	0.7
Severe depression (siblings)	0.2	0.2	0.3	0.5	0.6	-0.3	0.6
Leg fat-free mass (left)	0.2	0.9	1.7	1.1	-0.9	-0.9	-1.3
Stomach or abdominal pain in last month	0.2	0.3	1.2	1.1	0.1	-0.3	0.3
Impedance of leg (left)	0.2	0.8	2.2	-1.5	-1.1	-0.6	0.1
Leg predicted mass (left)	0.2	0.8	1.6	1.1	-0.8	-0.8	-1.3
Number of incorrect matches in round	0.2	0.4	1.3	-0.6	-0.6	0.0	-1.1
Had other major operations	0.2	0.2	0.4	-0.6	0.2	0.6	0.5
Forced vital capacity (FVC)	0.2	0.8	3.9	2.0	0.1	0.3	0.4
Qualifications: None of the above	0.2	0.5	1.3	-0.4	-0.8	-1.1	-0.7
Diabetes (self-reported)	0.2	0.3	0.7	0.2	0.6	0.6	0.8
Medication: Ramipril	0.2	0.3	0.6	0.2	-0.3	-0.7	-0.8
Weight	0.2	1.0	4.6	2.1	-0.4	-0.4	-0.5
Falls in the last year	0.2	0.3	0.8	-0.7	-0.0	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.0	-0.6	-0.4	-0.9
Medication: Lansoprazole	0.2	0.2	0.8	-0.5	0.3	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.1	1.4	-0.0	0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.1	0.8	0.2	1.0
Pulse wave reflection index	0.2	0.3	0.7	-0.6	-0.5	-0.5	-0.8
Loud music exposure frequency	0.2	0.2	0.5	-0.4	-0.2	-0.7	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	0.7	-0.8	-0.8	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.9	1.4	0.2	0.8	0.5
Worry too long after embarrassment	0.2	0.4	1.0	0.6	1.0	0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.8	0.7	0.1	0.3
Comparative height size at age 10	0.2	1.4	2.9	-0.5	-1.7	-1.1	-1.5
Leg fat-free mass (right)	0.2	0.9	2.2	0.9	-1.0	-0.8	-1.5
Commuting to job workplace: Walk	0.2	0.3	0.4	0.5	0.6	0.5	0.6
Leg predicted mass (right)	0.2	0.8	2.0	0.8	-1.0	-0.7	-1.4
Average weekly champagne plus white wine intake	0.2	0.2	0.8	-0.1	0.4	0.3	0.9
Hearing aid user	0.2	0.3	0.9	-0.9	0.4	0.6	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.2	-0.4	-0.8	-0.7
Medication: Atorvastatin	0.2	0.2	0.9	-1.0	-0.1	0.4	-0.1
Illnesses of father: High blood pressure	0.2	0.3	0.9	-1.0	-0.3	-0.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.7	-0.5	-0.4	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	0.4	0.3	0.0	0.9
Major Depression (MDD)	0.1	0.2	0.5	-0.7	0.1	-0.4	0.3
Fasting Glucose	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.4
HDL Cholesterol	0.1	0.2	0.8	-0.1	0.4	0.9	0.2
Rheumatoid Arthritis	0.1	0.2	0.5	-0.7	-0.6	-0.2	-0.0
Blood Eosinophil Count	0.1	0.4	1.3	0.1	1.1	0.3	0.9
Blood Red Count	0.1	0.8	2.2	-0.5	1.2	1.5	0.2
Heel T-Score	0.1	0.5	0.9	-0.7	0.9	0.7	0.9
Waist Hip Ratio (WHR)	0.1	0.3	1.2	-1.1	0.1	0.5	-0.1
Systolic Blood Pressure	0.1	0.4	0.7	0.8	0.6	0.8	0.8
Cardiovascular Disease	0.1	0.4	1.1	0.3	-0.9	-0.5	-1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.1	-0.6	-0.3	-0.7
Lung FEV1/FVC ratio	0.1	0.8	3.6	1.9	-0.1	-0.0	0.4
Relative age of first facial hair	0.1	0.2	0.8	-0.2	0.5	0.9	0.3
Vitamin and mineral supplements	0.1	0.2	0.6	0.4	0.3	0.8	0.4
Impedance of leg (right)	0.1	0.6	2.5	-1.6	-0.5	-0.5	0.5
Average weekly fortified wine intake	0.1	0.1	0.3	-0.3	0.3	0.5	0.0
Age when periods started (menarche)	0.1	0.1	0.4	0.0	0.1	0.6	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.7	-0.5	-0.1	-0.2
Past tobacco smoking	0.1	0.1	0.3	0.3	0.1	0.5	0.3
Mouth/teeth dental problems	0.1	0.1	0.3	-0.2	0.4	0.5	0.2
Trunk fat-free mass	0.1	0.3	1.2	-0.1	-0.4	-0.3	-1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.2	-0.6	-0.4	-0.7
Lung cancer (father)	0.1	0.1	0.4	0.7	-0.2	0.2	0.4
Length of working week for main job	0.1	0.2	0.5	0.5	-0.0	0.7	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.2	0.6	0.1	0.2
Medication: Paracetamol	0.1	0.1	0.5	0.7	-0.2	-0.2	-0.2
Headache pain in last month	0.1	0.2	0.7	0.3	0.5	0.4	0.8
Gout (self-reported)	0.1	0.2	0.4	0.5	-0.2	-0.7	-0.5
Arm fat-free mass (right)	0.1	0.6	1.7	0.7	-0.7	-0.5	-1.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.2	-0.3	-0.8	-0.6
Medication: Blood pressure	0.1	0.1	0.4	0.0	-0.5	-0.3	-0.6
Medication: Allopurinol	0.1	0.1	0.2	0.5	0.3	-0.1	0.2
Medication: Omeprazole	0.1	0.1	0.3	-0.5	-0.1	0.2	-0.4
Arm predicted mass (right)	0.1	0.4	1.3	0.6	-0.6	-0.4	-1.1
Alcohol intake frequency.	0.1	0.3	0.9	1.0	0.4	-0.1	0.6
Had major operations	0.1	0.2	0.5	0.5	-0.7	0.0	-0.3
Age at last live birth	0.1	0.2	0.4	-0.6	-0.3	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.3	0.4	0.4	0.0
Knee pain experienced in last month	0.1	0.2	0.4	0.5	-0.6	-0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.7	0.2	0.2	0.0
Illnesses of father: Heart disease	0.1	0.2	0.6	0.1	0.0	-0.6	-0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.4
Whole body fat-free mass	0.1	0.6	1.8	0.4	-0.7	-0.6	-1.4
Ever had bowel cancer screening	0.1	0.1	0.2	0.0	-0.3	-0.5	-0.5
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.3
Whole body water mass	0.1	0.6	2.1	0.3	-0.8	-0.7	-1.4
Financial situation satisfaction	0.1	0.1	0.2	0.4	-0.4	0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.3	0.6	0.1	-0.4	0.1
Medication: Lisinopril	0.1	0.1	0.5	0.7	-0.1	-0.1	0.1
Ever smoked	0.1	0.1	0.4	-0.6	0.3	0.1	0.0
Basal metabolic rate	0.1	0.6	1.4	0.7	-0.7	-0.6	-1.2
Arm fat-free mass (left)	0.1	0.4	1.1	0.9	-0.3	-0.2	-1.0
Number of operations (self-reported)	0.1	0.2	0.6	0.7	-0.4	-0.0	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	-0.4	-0.0	-0.4
Cholesterol lowering medication	0.1	0.2	0.6	-0.8	-0.3	-0.3	-0.0
Pain experienced in last month	0.1	0.1	0.2	-0.4	0.4	0.5	0.2
Heart disease (siblings)	0.1	0.1	0.3	0.2	0.5	-0.1	-0.1
Arm predicted mass (left)	0.1	0.4	1.1	0.9	-0.4	-0.2	-1.1
LDL Cholesterol	0.0	0.0	0.1	0.1	0.3	0.2	0.1
Hair Pigment	0.0	0.2	1.1	-1.1	-0.2	0.1	0.2
Tanning	0.0	0.3	0.8	-0.6	-0.3	0.2	-0.9
Ever had hysterectomy (womb removed)	0.0	0.0	0.2	0.0	0.1	0.5	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.2	-0.5	0.1	-0.1	0.1
Pulse rate	0.0	0.0	0.2	0.1	0.5	-0.1	-0.1
Noisy workplace	0.0	0.1	0.2	-0.4	-0.0	0.0	0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	-0.1	-0.3	-0.1	0.5
Trunk predicted mass	0.0	0.2	1.0	-0.1	-0.3	-0.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.3	-0.3	-0.1	0.0
Pulse rate, automated reading	0.0	0.1	0.2	0.2	0.3	0.0	-0.4
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	0.2	0.0	-0.0
Smoking status: Previous	0.0	0.0	0.2	-0.1	0.1	-0.4	-0.1
Osteoporosis (self-reported)	0.0	0.0	0.1	0.4	0.1	-0.1	0.2
Alcohol drinker status: Never	0.0	0.1	0.1	-0.4	0.0	-0.3	0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.2	0.1	-0.3	0.1

Hub : Genes

BRD7

Models

Trait associations