TWAS hub - NKD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.217	0.0810	0.00470	-0.002	NA	0.048	NA	0.036	4.1e-01	NA	2.5e-03	NA	7.6e-03
2	GTEx	Nerve Tibial	0.224	0.0632	0.00018	0.001	NA	0.014	NA	0.005	2.9e-01	NA	3.1e-02	NA	1.4e-01
3	GTEx	Testis	0.240	0.0670	0.00092	0.127	NA	0.135	NA	0.141	2.9e-06	NA	1.4e-06	NA	8.1e-07
4	TCGA	Prostate Adenocarcinoma	0.108	0.0487	0.00240	0.008	0.02	0.025	NA	0.012	4.0e-02	0.0031	1.2e-03	NA	1.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4
Crohns Disease (2017)	20.1	44.2	97.1	-8.6	9.9	-2.2
Crohns Disease (2012)	16.6	26.7	69.6	-4.9	8.3	-3.7
Irritable Bowel Disease (IBD)	9.6	22.8	57.0	-5.8	7.5	-0.6
Lung cancer (father)	3.0	3.5	12.3	-3.5	0.9	-1.1
Qualifications: CSEs or equivalent	2.4	3.2	6.1	-1.4	2.5	-2.2
Average weekly beer plus cider intake	2.4	3.4	7.8	-2.1	2.8	-1.2
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	5.2	2.3	-0.6	-2.2
Medication: Bendroflumethiazide	2.3	3.5	10.0	0.2	3.2	-2.0
Hair/balding pattern: Pattern 2	2.2	2.8	6.0	2.1	0.6	-2.5
Ever used hormone-replacement therapy (HRT)	2.0	2.5	8.3	-0.9	2.9	1.0
Had menopause	2.0	2.6	6.1	-1.9	0.7	2.5
Alzheimer’s Disease (in father)	1.9	2.0	4.8	-2.2	-0.1	1.9
Depression (self-reported)	1.9	2.3	8.3	-0.3	2.9	0.9
Gout (self-reported)	1.9	2.6	7.1	2.7	-0.3	-1.7
Alzheimer’s Disease (including proxy)	1.8	2.5	7.0	-1.7	0.4	2.6
High blood pressure (mother)	1.8	2.5	5.0	2.2	-0.2	-2.2
Pulse wave reflection index	1.8	2.2	7.0	1.0	1.0	2.6
Illnesses of siblings	1.7	2.3	5.7	-2.4	0.7	1.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	7.5	2.7	-0.7	1.0
Fasting Glucose	1.6	1.9	3.8	1.4	-1.4	2.0
Commuting to job workplace: Public transport	1.6	1.9	5.6	1.0	-1.1	2.4
Medication: Lisinopril	1.6	2.1	6.3	0.8	-1.2	2.5
Ulcerative Colitis (UC)	1.5	2.9	6.2	-1.3	2.5	1.9
Ovarian Cancer	1.5	2.0	3.8	1.9	-2.0	-1.0
Happiness	1.5	1.8	4.8	2.2	-0.0	1.6
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.6	0.4	2.4	1.5
Irritability	1.5	2.6	5.9	2.4	1.5	1.5
Medication: Metformin	1.4	2.0	8.0	2.8	0.1	0.2
Medication: Blood pressure	1.4	2.7	6.0	0.4	2.2	-2.5
Smoking Status	1.3	3.2	6.4	-1.0	2.3	2.5
Respiratory disease	1.3	3.0	11.5	0.3	3.4	-0.7
Hearing difficulty/problems: Yes	1.3	2.0	4.9	0.7	-1.6	2.2
Angina	1.3	1.7	3.5	1.2	-1.9	1.4
Current tobacco smoking	1.3	2.2	6.6	-1.4	2.6	0.4
Mood swings	1.3	2.4	6.1	1.4	2.5	1.2
Smoking status: Current	1.3	2.0	5.8	-1.4	2.4	0.4
Pain experienced in last month	1.3	2.2	7.0	1.3	-2.7	-0.6
Basal cell carcinoma (self-reported)	1.3	1.5	4.0	2.0	0.3	-1.4
Alcohol drinker status: Previous	1.3	1.5	5.4	2.3	-0.6	0.5
Number of treatments/medications taken	1.2	2.1	5.0	0.2	2.2	-1.8
Pack years adult smoking proportion	1.2	1.8	6.8	-0.5	2.6	0.4
Medication: Amlodipine	1.2	1.6	3.5	1.1	1.4	-1.9
Angina (self-reported)	1.2	1.6	3.3	0.9	-1.8	1.4
Medication: Allopurinol	1.2	1.6	3.8	1.6	-0.3	-1.9
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.4	-1.5	1.6	-0.9
Average weekly champagne plus white wine intake	1.2	1.7	6.1	-0.2	-2.5	0.7
Breast Cancer	1.1	2.5	5.5	1.0	-1.9	2.3
Heel T-Score	1.1	9.0	17.4	-3.3	2.8	-4.2
Fed-up feelings	1.1	1.9	5.2	1.4	2.3	-0.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.8	1.6	0.3	-1.7
Diabetes (self-reported)	1.1	1.7	6.9	2.6	-0.1	-0.3
Mouth/teeth dental problems: Dentures	1.1	1.9	3.9	-2.0	-0.4	1.9
High blood pressure (siblings)	1.1	1.6	5.0	2.2	1.1	-0.2
Age at last live birth	1.1	1.6	4.2	0.2	-1.5	-2.1
Illnesses of siblings: Diabetes	1.1	1.4	3.3	0.6	-1.4	-1.8
Osteoporosis (self-reported)	1.1	1.4	2.9	0.5	1.7	-1.6
Number of self-reported non-cancer illnesses	1.1	2.0	6.7	-0.5	2.6	-1.0
Hearing aid user	1.1	1.2	2.5	1.5	-0.1	-1.6
Mother’s age at death	1.1	1.4	2.1	1.4	-1.3	1.3
Alzheimer’s Disease (in mother)	1.0	1.1	3.0	-0.7	1.1	1.7
Schizophrenia (2014)	1.0	2.1	4.4	-0.8	2.1	1.9
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.2	-2.0	0.8	0.1
Ulcerative Colitis	1.0	1.4	2.4	-1.4	1.5	1.2
Taking other prescription medications	1.0	1.5	4.6	0.9	2.2	0.6
High blood pressure	1.0	2.7	9.7	0.7	3.1	-0.7
Heart attack	1.0	1.3	3.4	-0.1	-1.3	1.9
Alcohol intake versus 10 years previously	1.0	1.5	6.1	-0.2	2.5	0.0
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.8	-0.5	-1.9	-2.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.1	-0.6	-1.4	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	-1.3	1.3	-1.2
Wears glasses or contact lenses	1.0	1.2	4.0	2.0	0.8	-0.0
Illnesses of father: High blood pressure	1.0	1.2	3.3	0.8	1.8	-0.9
Pack years of smoking	1.0	1.5	5.0	-0.6	2.2	0.7
Ever had hysterectomy (womb removed)	0.9	1.0	3.7	1.9	0.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.8	-2.0	-0.1	0.4
Hearing difficulty/problems with background noise	0.9	1.4	3.8	-0.7	-1.2	2.0
Financial difficulties in last 2 years	0.9	1.2	2.6	1.4	0.4	-1.6
Allergy	0.9	2.1	7.5	0.5	-2.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.8	-1.0	-2.6	-1.8
Birth weight of first child	0.9	1.7	5.3	-1.2	-0.4	-2.3
Eye problems/disorders: None of the above	0.9	1.0	3.4	-1.8	-0.9	-0.0
Hypertension (Self-reported)	0.9	2.4	8.2	0.7	2.9	-1.0
Illnesses of father: Heart disease	0.9	1.2	2.5	1.4	0.7	1.6
Smoking status: Previous	0.9	1.3	5.2	0.2	0.3	2.3
Ever had bowel cancer screening	0.9	1.0	1.8	0.8	1.3	1.3
Diabetes diagnosed by doctor	0.9	1.5	4.5	2.1	0.6	-1.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.6	-1.6	-1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.7	0.2	-0.7	-1.9
Heart disease (siblings)	0.9	1.1	3.8	1.9	-0.8	0.0
Bipolar Disorder or Schizophrenia	0.8	2.0	3.0	-1.6	1.7	1.6
Depressed Affect (Nagel 2018)	0.8	1.6	3.8	1.9	1.5	-0.7
Neuroticism (Nagel 2018)	0.8	1.8	4.4	2.1	1.6	0.1
Schizophrenia (2018)	0.8	1.6	3.1	-0.8	1.6	1.8
Medication: Co-codamol	0.8	0.9	2.0	0.3	1.2	-1.4
Medication: Ramipril	0.8	1.0	2.6	0.2	1.1	-1.6
Forced vital capacity (FVC), Best measure	0.8	2.9	5.3	-1.1	-2.3	-2.3
Emphysema/chronic bronchitis	0.8	0.9	3.5	-0.1	1.9	0.5
Chest pain or discomfort	0.8	1.2	4.8	2.2	-0.1	0.1
Long-standing illness, disability or infirmity	0.8	1.2	2.7	1.6	1.3	-0.7
Commuting to job workplace: Walk	0.8	0.8	2.0	0.2	-1.1	1.4
Age started oral contraceptive pill	0.8	1.0	3.3	0.9	1.8	-0.0
Unable to work because of sickness or disability	0.8	1.1	3.2	-0.2	1.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.6	-0.1	-1.2	1.6
Bipolar Disorder (2018)	0.7	1.2	3.7	-1.9	0.8	0.6
Worry (Nagel 2018)	0.7	1.4	3.4	1.8	1.4	0.6
Mean Putamen Volume	0.7	0.8	2.7	-1.6	-0.6	0.1
HbA1C	0.7	0.8	2.0	1.4	0.4	-1.0
Hypothyroidism (self reported)	0.7	1.7	5.9	0.8	2.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.2	1.8	1.3	-0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.4	1.5	0.2	-0.9
Townsend deprivation index at recruitment	0.7	1.0	2.2	1.2	0.7	1.5
Mouth/teeth dental problems	0.7	1.1	3.2	0.1	1.1	-1.8
Fluid intelligence score	0.7	1.4	5.3	-0.3	-2.3	-0.5
Standing height	0.7	6.9	15.0	-3.3	1.2	-3.9
Headache pain in last month	0.7	1.2	2.4	-1.5	1.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	4.7	1.0	2.2	-0.4
Medication: Ibuprofen	0.7	0.8	1.9	-1.4	0.8	-0.9
Medication: Omeprazole	0.7	0.8	2.5	0.5	-0.6	-1.6
Medication: Aspirin	0.7	0.9	2.4	0.5	-1.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	-0.7	0.7	-1.5
Friendships satisfaction	0.7	0.8	3.1	1.7	-0.2	0.4
Osteoarthritis (self-reported)	0.7	0.9	3.5	0.4	0.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	4.8	0.2	-2.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	0.7	1.4	0.9
Medication: Paracetamol	0.7	1.1	3.6	-1.9	0.6	-0.7
Fractured/broken bones in last 5 years	0.7	1.0	1.8	-1.3	0.6	1.3
Vascular/heart problems diagnosed by doctor	0.7	2.0	7.5	-0.7	-2.7	0.3
Prostate Cancer	0.6	0.8	1.9	1.2	-0.2	-1.4
BMI	0.6	3.3	8.0	2.8	2.0	1.1
Systolic Blood Pressure	0.6	3.2	11.7	-0.7	0.6	-3.4
Allergy or Eczema	0.6	1.6	3.4	-0.1	1.8	-1.8
Cardiovascular Disease	0.6	1.8	4.6	0.4	2.1	-1.6
Neuroticism	0.6	1.5	4.4	2.1	0.9	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.9	0.2	1.7	-0.2
Relative age voice broke	0.6	0.9	2.2	-0.4	1.2	-1.5
Serious illness, injury or assault to yourself	0.6	0.7	1.7	-1.3	0.1	-1.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.4	-0.5	1.9	-1.4
Body mass index (BMI)	0.6	2.5	5.6	2.4	1.2	1.7
Nervous feelings	0.6	1.1	2.8	1.7	0.7	1.1
Had other major operations	0.6	0.7	1.9	-0.9	0.1	1.4
Forced vital capacity (FVC)	0.6	2.4	4.6	-1.4	-2.2	-1.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-0.1	1.4	-1.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.1	-1.4	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.7	-1.0	-2.4	-1.3
Pulse rate	0.6	1.0	2.4	-0.9	-0.8	-1.6
Hair/balding pattern: Pattern 4	0.6	1.4	5.2	0.7	-0.1	2.3
Exposure to tobacco smoke outside home	0.6	0.8	1.6	-0.6	1.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	0.5	1.6	-0.1
Health satisfaction	0.6	0.7	2.6	-0.3	0.5	-1.6
Migraine (self-reported)	0.6	0.7	2.3	-0.6	1.5	-0.4
Overall health rating	0.6	1.3	4.3	0.8	2.1	-0.4
Loneliness, isolation	0.6	0.8	2.3	0.9	-0.0	1.5
Qualifications: nursing, teaching	0.6	0.9	3.2	-1.8	-0.3	-0.7
Back pain experienced in last month	0.6	0.8	1.8	-1.3	1.0	-0.7
Mineral and other dietary supplements	0.6	0.8	1.3	-1.1	-1.1	-0.9
Medication: Aspirin	0.6	0.8	2.3	0.4	-1.5	0.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.7	0.9	-1.3
Alcohol drinker status: Never	0.6	0.7	1.6	0.7	0.8	-1.3
Supplements: Calcium	0.6	0.6	1.9	1.4	0.7	0.0
Bipolar Disorder (2011)	0.5	0.5	1.4	-0.1	1.2	0.7
Lung FVC	0.5	2.6	10.2	-0.0	-3.2	0.4
Average weekly spirits intake	0.5	0.6	1.7	0.4	-0.8	1.3
Relative age of first facial hair	0.5	1.0	3.4	-0.2	1.9	-0.6
Diabetes (father)	0.5	0.6	1.9	1.4	-0.3	-0.7
Hand grip strength (right)	0.5	1.3	2.9	-1.1	-1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.4	1.0	1.9	-0.6
Medication: Atenolol	0.5	0.6	2.1	-0.3	-0.3	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.0	0.8	1.4	-1.4
Qualifications: None of the above	0.5	1.1	2.3	0.5	1.4	1.5
Neuroticism score	0.5	1.1	3.1	1.8	1.0	0.6
Arm fat percentage (right)	0.5	1.9	5.5	2.3	0.7	1.2
Time employed in main current job	0.5	0.6	1.6	0.7	1.3	0.6
Falls in the last year	0.5	0.6	0.9	-0.9	0.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.8	-1.3	0.4	-0.7
Breastfed as a baby	0.5	0.7	1.8	0.0	-1.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.8	0.6	0.2	1.7
Number of full brothers	0.5	0.7	2.6	0.1	-0.2	1.6
Qualifications: College or University degree	0.5	1.6	6.0	-0.1	-2.4	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	2.2	1.5	-0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.2	0.5	0.1	1.5
Had major operations	0.5	0.6	1.1	-1.1	-0.4	-1.1
Knee pain experienced in last month	0.5	0.8	3.1	0.3	1.8	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	-0.3	0.7	-1.4
Average weekly red wine intake	0.5	0.8	3.2	1.8	-0.1	-0.1
Medication: Gliclazide	0.5	0.5	1.7	0.6	0.0	1.3
Financial situation satisfaction	0.5	0.7	1.7	1.0	-0.2	-1.3
Medication: Atorvastatin	0.5	0.6	1.7	0.8	-0.4	1.3
Depression (Nagel 2018)	0.4	0.5	1.0	1.0	-0.8	-0.8
Major Depression (MDD)	0.4	0.5	1.5	-1.2	0.0	0.7
Reaction Time	0.4	0.8	2.3	1.5	-0.2	-0.9
Neuroticism (2016)	0.4	0.6	1.3	1.0	0.5	1.1
Triglycerides	0.4	0.6	1.7	-1.3	-0.8	0.2
Hand grip strength (left)	0.4	1.1	2.5	-0.2	-1.3	-1.6
Severe depression (siblings)	0.4	0.4	1.0	-1.0	-0.2	-0.8
Average weekly fortified wine intake	0.4	0.5	1.1	-0.8	-1.0	-0.5
Maternal smoking around birth	0.4	0.6	0.9	-0.8	0.9	-0.8
Age when periods started (menarche)	0.4	0.9	3.1	-1.8	0.7	-0.1
Stomach or abdominal pain in last month	0.4	0.5	1.9	0.3	1.4	0.2
Medication: Levothyroxine sodium	0.4	0.7	2.0	0.3	1.4	1.0
Number of incorrect matches in round	0.4	0.6	1.6	0.2	0.9	1.2
Past tobacco smoking	0.4	0.7	2.4	0.0	-0.7	-1.6
Alcohol usually taken with meals	0.4	0.7	2.5	-0.4	-1.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	1.1	-0.8	0.5
Worrier / anxious feelings	0.4	0.8	2.7	1.6	0.1	0.6
Asthma	0.4	0.8	2.7	-0.1	1.6	-0.7
Medication: Lansoprazole	0.4	0.4	1.4	1.2	0.1	-0.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-1.2	0.1	0.8
Impedance of arm (left)	0.4	1.8	4.5	-2.1	-1.4	-0.8
Arm fat mass (right)	0.4	1.6	3.8	2.0	1.4	0.7
Loud music exposure frequency	0.4	0.4	1.4	0.3	0.5	1.2
Medication: Paracetamol	0.4	0.6	1.6	-1.3	0.6	-0.6
Comparative body size at age 10	0.4	1.2	3.1	1.8	-0.4	1.2
Worry too long after embarrassment	0.4	0.6	1.5	0.7	-0.7	1.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	0.6	1.5	0.3
Pulse wave peak to peak time	0.4	0.4	1.0	0.8	0.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-1.1	0.3	0.7
Mean time to correctly identify matches	0.4	0.7	2.2	1.5	-0.7	-0.1
Number of full sisters	0.4	0.5	1.4	0.5	-1.2	-0.4
Suffer from ‘nerves’	0.4	0.6	1.7	0.7	1.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	-1.3	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	-0.6	0.4	-1.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.7	-0.2	-1.1
Miserableness	0.4	0.6	1.7	0.8	-0.3	-1.3
Ever taken oral contraceptive pill	0.4	0.5	1.0	0.5	1.0	0.8
Leg fat percentage (left)	0.4	1.4	3.5	1.3	0.6	1.9
Impedance of whole body	0.4	1.9	5.1	-2.3	-1.2	-1.0
HDL Cholesterol	0.3	0.5	1.7	1.3	0.2	0.6
Blood White Count	0.3	1.9	7.0	2.6	-0.5	-0.5
Height	0.3	6.1	16.4	-2.5	1.4	-4.0
Chronotype (morning person)	0.3	0.6	1.8	-0.1	-1.3	0.8
Sensitivity / hurt feelings	0.3	0.6	2.3	1.5	0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	0.9	-0.9	0.0
Impedance of leg (right)	0.3	1.4	3.4	-1.8	-0.8	-1.3
Leg fat-free mass (left)	0.3	1.3	4.2	0.4	2.0	-1.0
Trunk fat percentage	0.3	1.0	2.1	0.8	1.1	1.4
Multivitamins +/- minerals	0.3	0.4	1.5	-0.3	1.2	-0.1
Supplements: Glucosamine	0.3	0.4	1.2	-1.1	0.4	-0.3
Sitting height	0.3	2.0	6.6	-1.1	-0.3	-2.6
Impedance of leg (left)	0.3	1.6	4.5	-2.1	-1.0	-0.9
Leg predicted mass (left)	0.3	1.4	4.5	0.3	2.1	-1.0
Waist circumference	0.3	1.2	2.7	1.2	1.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.6	-0.4	1.3	0.5
Impedance of arm (right)	0.3	1.6	3.1	-1.2	-1.3	-1.8
Father’s age at death	0.3	0.4	1.7	-0.1	-1.3	-0.0
Noisy workplace	0.3	0.4	0.9	-0.4	0.9	-0.7
Prospective memory result	0.3	0.4	1.4	-1.2	-0.0	-0.2
Illnesses of mother	0.3	0.3	0.6	-0.8	0.6	0.6
Length of working week for main job	0.3	0.4	1.3	-0.3	0.2	-1.1
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.5	-0.6	-0.8
Tense / ‘highly strung’	0.3	0.5	1.5	-0.3	1.2	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.3	0.6	1.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	0.1	1.1	0.2
Body fat percentage	0.3	1.2	2.0	1.3	1.0	1.4
Leg fat percentage (right)	0.3	1.1	2.1	1.3	0.7	1.5
Age at first live birth	0.3	0.6	2.1	0.0	-0.4	-1.5
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.6	1.0	-0.7
Medication: Blood pressure	0.3	0.4	1.3	1.1	0.6	0.4
Whole body fat mass	0.3	1.1	1.9	1.1	1.4	1.1
Comparative height size at age 10	0.3	1.9	4.4	-1.6	0.7	-2.1
Family relationship satisfaction	0.3	0.3	0.9	0.3	-0.9	0.6
Leg pain on walking	0.3	0.4	0.9	0.8	-0.9	-0.2
Supplements: Vitamin C	0.3	0.3	1.1	-0.4	1.0	-0.3
Arm fat percentage (left)	0.3	1.3	3.0	1.7	0.6	1.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.9	0.7	-0.2
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.9	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	0.5	-0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.7	0.8	0.2
Asthma (self-reported)	0.3	0.7	2.3	-0.4	1.5	-0.5
Arm fat mass (left)	0.3	1.2	2.4	1.5	1.3	0.9
Arm fat-free mass (left)	0.3	1.3	4.9	0.4	2.2	-0.2
Myopia	0.3	0.4	0.9	-0.6	-0.7	0.9
Leg fat mass (left)	0.3	1.0	1.7	1.2	1.3	1.0
Age at First Birth	0.2	0.3	0.5	0.3	-0.6	0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.5	0.6	0.3
Lupus	0.2	0.3	1.0	1.0	0.0	0.0
Rheumatoid Arthritis	0.2	0.3	1.3	-0.1	-1.1	0.2
Blood Platelet Count	0.2	2.2	6.6	2.6	-1.2	0.9
Waist Hip Ratio (WHR)	0.2	0.9	2.8	-0.2	-0.9	-1.7
Systolic blood pressure, automated reading	0.2	0.6	1.7	0.4	1.3	-0.8
Vitamin and mineral supplements	0.2	0.3	0.9	0.2	-0.9	-0.3
Supplements: Zinc	0.2	0.2	0.8	0.0	0.3	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.6	0.7	-0.0
Trunk fat mass	0.2	0.9	2.1	0.8	1.4	0.9
Pain all over the body in last month	0.2	0.2	0.6	-0.5	0.8	0.2
Weight	0.2	0.9	2.9	0.9	1.7	-0.1
Trunk fat-free mass	0.2	1.2	3.3	-0.3	1.8	-1.2
Hip circumference	0.2	1.0	1.8	1.0	1.1	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.4	1.1	0.2
Trunk predicted mass	0.2	1.2	3.1	-0.3	1.8	-1.2
Peak expiratory flow (PEF)	0.2	0.4	1.1	0.3	-1.1	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.0	0.8	-0.7
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.4	0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.9	-0.3	0.1
Birth weight	0.2	0.3	0.5	0.7	-0.7	0.6
Arm fat-free mass (right)	0.2	1.0	4.1	-0.0	2.0	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.8	-0.9	0.3	-0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.6	-0.8	-0.5	0.5
Leg fat mass (right)	0.2	0.9	1.6	1.2	1.3	0.7
Arm predicted mass (right)	0.2	1.2	4.6	-0.2	2.1	-0.4
Whole body fat-free mass	0.2	1.3	4.3	-0.0	2.1	-1.0
Leg fat-free mass (right)	0.2	1.3	4.4	0.2	2.1	-0.9
Medication for cholesterol	0.2	0.4	0.6	-0.7	-0.6	0.8
Whole body water mass	0.2	1.3	4.1	0.0	2.0	-1.1
Leg predicted mass (right)	0.2	1.3	4.3	0.1	2.1	-0.9
Guilty feelings	0.2	0.2	0.7	0.8	0.5	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.7	0.3	0.3
Basal metabolic rate	0.2	1.3	4.2	0.2	2.1	-0.9
Number of operations (self-reported)	0.2	0.3	0.8	-0.3	0.9	0.5
Risk taking	0.2	0.3	1.1	-1.0	-0.5	0.2
Diastolic blood pressure, automated reading	0.2	0.6	2.0	-0.5	1.4	-0.4
Arm predicted mass (left)	0.2	1.1	4.0	0.4	2.0	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.8	-0.2	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.8	0.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	0.0	-0.8	-0.9
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.5	0.0
LDL Cholesterol	0.1	0.1	0.3	0.5	-0.1	-0.1
Blood Eosinophil Count	0.1	1.0	2.5	1.6	0.5	1.1
Blood Red Count	0.1	1.0	1.7	0.9	-1.3	1.2
Lung FEV1/FVC ratio	0.1	0.4	0.6	-0.7	-0.8	0.5
Diabetes (mother)	0.1	0.1	0.2	0.4	-0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	0.3	-0.0
Medication: Simvastatin	0.1	0.2	0.3	0.5	0.4	-0.3
Number of live births	0.1	0.1	0.5	-0.1	0.7	0.1
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	-0.4	0.6
Number of children fathered	0.1	0.1	0.5	0.1	0.3	-0.7
Pulse rate, automated reading	0.1	0.2	0.5	-0.4	-0.1	-0.7
Alcohol intake frequency.	0.1	0.2	0.6	-0.2	0.5	0.8
Breast cancer (self-reported)	0.1	0.1	0.4	-0.6	-0.3	-0.1
Ever smoked	0.1	0.2	0.5	0.3	0.7	0.6
Ever depressed for a whole week	0.1	0.1	0.1	0.3	-0.4	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.7	-0.0	-0.1
Cholesterol lowering medication	0.1	0.2	0.8	-0.0	-0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.2	0.6	-0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.0	-0.1
Hair Pigment	0.0	0.4	1.6	-0.4	0.1	1.3
Tanning	0.0	0.1	0.4	0.4	-0.0	0.6
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.3	-0.2	0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	0.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.2	-0.4	0.2	0.0
Heart disease (mother)	0.0	0.0	0.1	-0.3	0.1	0.2
High cholesterol (Self-reported)	0.0	0.1	0.2	0.4	0.2	0.4

Hub : Genes

NKD1

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Trait associations