TWAS hub - NOD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.6000	0.1320	1.9e-03	-0.008	NA	0.019	NA	-0.002	6.9e-01	NA	8.7e-02	NA	3.7e-01
2	GTEx	Esophagus Mucosa	0.1870	0.0440	2.3e-07	0.136	NA	0.143	NA	0.148	2.2e-09	NA	8.0e-10	NA	4.1e-10
3	GTEx	Nerve Tibial	0.1407	0.0405	7.4e-05	0.063	NA	0.087	NA	0.087	2.9e-05	NA	9.6e-07	NA	9.4e-07
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1550	0.0530	7.5e-04	0.061	NA	-0.003	NA	0.023	2.8e-04	NA	4.9e-01	NA	1.9e-02
5	GTEx	Whole Blood	0.3750	0.0530	0.0e+00	0.331	NA	0.327	NA	0.327	2.3e-31	NA	6.6e-31	NA	6.5e-31
6	NTR	Blood	0.1548	0.0210	0.0e+00	0.181	0.161	0.180	0.183	0.183	3.1e-56	1.1e-49	1.0e-55	1.3e-56	7.1e-57
7	TCGA	Lung Adenocarcinoma	0.0667	0.0489	4.3e-03	0.007	0.016	0.021	NA	0.022	4.4e-02	4.4e-03	1.3e-03	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5	6	7
Crohns Disease (2017)	48.9	107.3	350.5	13.5	1.7	13.1	-4.0	-5.1	18.7
Crohns Disease (2012)	37.6	60.5	203.7	10.2	1.5	9.7	-2.7	-3.6	14.3
Irritable Bowel Disease (IBD)	18.8	44.9	146.4	8.9	1.6	8.6	-2.0	-2.8	12.1
Medication: Simvastatin	4.9	7.2	13.7	-3.0	-3.7	-2.6	-3.3	-3.2	-0.2
Number of operations (self-reported)	4.2	6.2	13.2	3.5	1.9	3.6	0.4	0.6	3.6
Schizophrenia vs Biploar Disorder	4.0	5.2	10.8	3.3	1.9	3.3	1.1	1.4	2.9
Handedness (chirality/laterality): Left-handed	3.7	4.4	7.6	-2.4	-2.8	-2.3	-2.5	-2.4	-1.1
Medication: Levothyroxine sodium	3.5	6.0	12.5	-3.5	-2.5	-3.4	-1.5	-1.5	-2.7
Heart disease (mother)	3.4	4.1	8.4	2.9	1.8	2.8	1.0	1.0	2.8
Shortness of breath walking on level ground	3.2	3.8	9.9	-3.0	-1.9	-3.1	-1.2	-1.3	-0.7
Pain experienced in last month	2.7	4.6	11.9	-3.2	-1.9	-3.5	-0.7	-1.0	-2.1
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	9.6	-2.9	-2.5	-3.1	-1.9	-2.0	-1.8
Schizophrenia (2018)	2.5	5.2	9.3	3.0	2.8	2.8	2.1	2.2	1.3
Hypothyroidism (self reported)	2.5	5.7	9.8	-3.0	-2.8	-3.1	-2.4	-2.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	6.5	-2.2	-1.4	-2.5	-0.8	-0.8	-2.5
Neuroticism	2.4	5.7	11.1	3.3	2.4	3.3	1.5	1.9	2.4
Medication: Paracetamol	2.4	3.8	9.3	3.0	0.8	3.0	-0.1	-0.4	2.7
Eye problems/disorders: Cataract	2.3	2.7	4.4	-2.1	-1.7	-2.1	-1.3	-1.3	-2.0
Worry (Nagel 2018)	2.2	4.7	7.9	2.6	2.6	2.8	2.2	2.4	0.9
Schizophrenia (2014)	2.2	4.9	7.7	2.8	2.8	2.6	2.3	2.4	1.0
Medication for pain relief, constipation, heartburn	2.2	3.8	11.2	-2.8	-1.1	-3.4	-0.5	-0.6	-2.3
Average weekly beer plus cider intake	2.2	3.2	9.5	2.8	1.7	3.1	0.9	1.1	0.5
Stomach or abdominal pain in last month	2.1	2.7	4.9	2.1	2.2	1.9	1.6	1.5	0.6
Medication: Paracetamol	2.1	3.6	9.3	3.0	1.3	3.0	0.8	0.7	2.0
High blood pressure (siblings)	2.1	3.0	6.5	1.4	2.4	0.7	2.6	2.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	4.5	1.5	2.1	1.4	2.1	2.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.4	-1.4	1.3	-1.8	2.3	2.2	-2.5
Age at First Birth	2.0	2.9	6.2	-2.5	-2.2	-2.0	-1.3	-1.6	-0.9
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.6	-2.3	-1.5	-2.4	-1.1	-1.2	-0.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.4	-1.2	-2.0	-1.1	-2.0	-2.1	0.1
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	5.2	-1.3	-2.0	-1.0	-2.3	-2.3	0.4
Mouth/teeth dental problems: Loose teeth	2.0	2.4	5.8	1.3	1.6	1.4	1.8	2.4	-1.3
Medication: Ibuprofen	2.0	2.4	5.9	2.1	0.3	2.3	-0.6	-0.6	2.4
Leg pain on walking	1.9	2.3	4.3	-1.1	-1.7	-1.4	-2.1	-2.1	1.3
Hypertension (Self-reported)	1.9	5.2	13.2	1.2	3.0	1.0	3.5	3.6	-0.3
High cholesterol (Self-reported)	1.9	3.4	7.8	-2.5	-2.1	-2.8	-1.5	-1.6	-0.3
Fed-up feelings	1.8	3.3	6.9	2.5	2.1	2.6	1.3	1.5	1.3
Mouth/teeth dental problems	1.8	2.7	5.3	0.5	-1.7	0.8	-2.2	-2.3	2.3
Neuroticism score	1.8	3.7	7.9	2.7	2.0	2.8	1.3	1.6	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	5.8	2.2	0.9	2.4	0.3	0.2	2.0
Medication: Lansoprazole	1.8	2.1	4.2	-1.1	-1.9	-1.2	-2.1	-2.0	-0.4
Supplements: Fish oil (including cod liver oil)	1.8	2.4	5.4	0.8	1.9	0.9	2.2	2.3	-1.2
Cholesterol lowering medication	1.8	2.6	6.0	-2.4	-1.8	-2.4	-1.2	-1.2	-0.7
Had other major operations	1.7	2.1	6.2	2.2	0.7	2.5	-0.4	-0.3	1.7
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.5	-1.6	-1.9	-1.5	-2.1	-2.4	0.8
Number of full brothers	1.7	2.1	4.0	1.8	2.0	1.8	1.3	1.4	0.7
Commuting to job workplace: Walk	1.7	1.8	4.8	1.6	0.5	2.1	-0.5	-0.4	2.2
Commuting to job workplace: Cycle	1.7	2.1	5.0	-2.2	-1.4	-2.1	-1.2	-1.3	-0.4
Neuroticism (Nagel 2018)	1.6	3.7	5.9	2.3	2.1	2.4	1.9	2.1	1.4
Vitamin and mineral supplements	1.6	2.2	3.1	-1.7	-1.7	-1.8	-1.7	-1.7	-0.9
Had menopause	1.6	2.0	3.4	1.6	1.9	1.6	1.6	1.7	0.0
Depression (self-reported)	1.6	1.9	5.6	2.2	0.9	2.4	0.2	0.1	1.4
Chronic bronchitis/emphysema (mother)	1.6	1.9	6.2	-1.8	-0.5	-1.9	-0.2	-0.1	-2.5
Diastolic blood pressure, automated reading	1.6	5.1	11.7	1.4	2.8	1.3	3.4	3.4	-0.7
High blood pressure	1.5	4.1	10.9	0.9	2.5	0.7	3.2	3.3	-0.3
Multivitamins +/- minerals	1.5	1.9	3.3	1.7	1.6	1.8	1.2	1.2	1.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.4	-1.7	-2.2	-1.9	-2.2	-2.5	1.0
Loud music exposure frequency	1.5	1.6	6.3	-1.1	0.1	-1.5	0.9	1.0	-2.5
Rheumatoid Arthritis	1.4	1.9	4.6	-0.8	-2.0	-0.7	-2.1	-2.0	0.4
Systolic blood pressure, automated reading	1.4	4.0	10.8	0.5	2.2	0.5	3.1	3.3	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.6	1.9	1.9	1.7	1.2	1.3	1.5
Asthma	1.4	2.8	8.2	-0.5	-2.0	-0.3	-2.6	-2.9	0.4
Neck or shoulder pain in last month	1.4	2.0	6.3	1.8	0.8	2.0	-0.1	-0.1	2.5
Age started oral contraceptive pill	1.4	1.7	6.5	1.6	0.8	1.4	0.4	0.3	2.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.4	-1.5	-1.5	-1.4	-1.2	-1.1	-0.8
Hayfever, allergic rhinitis or eczema	1.3	2.8	6.4	0.6	-1.3	0.8	-2.1	-2.4	2.5
Had major operations	1.3	1.5	3.7	0.7	-1.1	0.7	-1.9	-1.6	1.5
Asthma (self-reported)	1.3	2.5	7.2	-0.6	-1.9	-0.4	-2.4	-2.7	0.2
Miserableness	1.3	2.2	5.1	-0.9	-2.0	-0.7	-2.3	-2.2	0.2
Alcohol drinker status: Never	1.3	1.6	2.4	-1.4	-1.4	-1.4	-1.5	-1.5	-0.8
Diabetes (mother)	1.2	1.6	3.5	-0.8	-1.7	-0.9	-1.8	-1.9	0.3
Time employed in main current job	1.2	1.3	2.9	0.9	1.6	0.8	1.4	1.7	-0.8
Tense / ‘highly strung’	1.2	2.0	3.1	1.6	1.6	1.8	1.6	1.6	0.8
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.0	-1.2	-1.7	-1.0	-1.5	-1.4	0.4
Pack years adult smoking proportion	1.1	1.7	4.8	-0.7	0.9	-0.9	1.5	1.6	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.9	1.9	1.3	2.0	0.8	0.8	1.3
Medication: Amlodipine	1.1	1.6	4.0	0.6	1.3	0.3	1.7	2.0	-1.4
Exposure to tobacco smoke outside home	1.1	1.5	2.9	1.4	1.5	1.7	1.2	1.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.1	1.3	1.2	1.4	1.0	0.9	1.8
Average weekly champagne plus white wine intake	1.1	1.5	3.8	-0.7	-1.5	-0.8	-1.9	-1.8	-0.3
Myopia	1.1	1.6	3.7	1.7	0.9	1.9	0.4	0.3	1.9
Vascular/heart problems diagnosed by doctor	1.1	3.0	7.5	-1.0	-2.2	-0.9	-2.6	-2.7	-0.3
Fasting Glucose	1.0	1.2	2.8	-1.6	-1.1	-1.7	-0.5	-0.5	-1.1
Ulcerative Colitis	1.0	1.4	2.2	1.3	1.5	1.0	1.3	1.1	1.4
Medication: Metformin	1.0	1.5	6.9	-1.1	-0.1	-1.1	0.6	0.7	-2.6
Diabetes (father)	1.0	1.2	1.8	-1.1	-1.3	-1.2	-1.3	-1.4	-0.9
Allergy	1.0	2.4	6.5	0.6	1.8	0.5	2.2	2.5	-1.1
Worrier / anxious feelings	1.0	1.9	4.2	1.7	1.6	2.1	1.1	1.4	0.0
Medication: Cholesterol lowering	1.0	1.6	3.5	-1.6	-1.9	-1.2	-1.3	-1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	1.2	1.5	1.0	1.0	0.9	1.1
Ever had bowel cancer screening	1.0	1.1	3.5	1.6	0.5	1.2	-0.1	-0.2	1.9
Commuting to job workplace: Public transport	1.0	1.2	3.6	0.1	-1.1	0.2	-1.9	-1.8	0.4
Alcohol drinker status: Previous	1.0	1.1	4.7	-0.4	0.7	-0.7	0.9	1.1	-2.2
Falls in the last year	0.9	1.3	2.8	0.9	-0.7	1.1	-1.4	-1.4	1.7
Migraine (self-reported)	0.9	1.1	2.1	1.3	1.4	1.3	0.7	0.7	0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	-0.7	-1.4	-0.8	-1.2	-1.5	1.0
Supplements: Vitamin C	0.9	1.1	1.7	1.2	1.2	1.0	1.3	1.3	0.7
Mood swings	0.9	1.7	2.9	1.5	1.6	1.7	1.2	1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.5	1.4	0.2	1.9	-0.3	-0.3	1.4
Medication: Gliclazide	0.9	1.0	6.0	-0.6	-0.6	-0.3	-0.3	-0.2	-2.4
Fractured/broken bones in last 5 years	0.9	1.2	4.5	0.2	1.0	0.4	1.1	1.2	-2.1
Pack years of smoking	0.9	1.3	4.4	-0.8	0.5	-1.0	1.1	1.3	-2.1
Ulcerative Colitis (UC)	0.8	1.4	2.2	1.4	1.5	1.4	1.2	1.1	1.1
Prostate Cancer	0.8	1.1	3.1	-1.7	-1.0	-1.8	-0.1	-0.0	-0.6
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.8	1.1	1.4	0.9	1.1	1.0	0.8
Smoking Status	0.8	1.8	3.4	1.1	1.8	1.1	1.8	1.8	-0.9
Qualifications: CSEs or equivalent	0.8	1.1	3.2	1.8	1.2	1.5	0.4	0.3	0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	-0.8	-1.3	-0.4	-1.5	-1.4	0.6
Blood clot in the leg (DVT)	0.8	1.0	1.9	-0.8	-1.2	-0.9	-1.3	-1.4	0.3
Angina (self-reported)	0.8	1.0	3.0	-1.4	-0.8	-1.0	-0.4	-0.5	-1.7
Suffer from ‘nerves’	0.8	1.2	2.2	1.1	1.5	1.2	1.4	1.4	0.1
Illnesses of father: Heart disease	0.8	1.1	5.1	-0.0	0.7	0.1	1.0	1.2	-2.3
Guilty feelings	0.8	1.2	3.2	1.6	0.2	1.8	-0.3	-0.1	1.6
Depression (Nagel 2018)	0.7	1.0	3.3	1.3	0.5	1.4	-0.1	0.2	1.8
Allergy or Eczema	0.7	1.9	4.2	0.4	-1.3	0.6	-1.8	-2.0	2.0
Angina	0.7	0.9	2.9	-1.3	-0.7	-1.0	-0.2	-0.2	-1.7
Medication: Atenolol	0.7	0.9	1.5	1.0	1.2	0.9	1.1	1.1	0.5
Nervous feelings	0.7	1.3	2.2	1.3	1.2	1.5	1.3	1.4	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	0.9	-0.6	1.3	-1.0	-0.9	1.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.0	1.1	0.8	0.9	0.6	0.3	1.7
Illnesses of siblings	0.7	1.0	2.6	-0.7	-1.3	-0.2	-1.5	-1.6	-0.2
Alcohol intake versus 10 years previously	0.7	1.1	2.3	0.6	1.4	0.7	1.4	1.5	-0.8
Happiness	0.7	0.9	1.2	-1.1	-1.1	-0.9	-1.0	-1.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	5.4	0.9	0.5	0.9	0.1	0.0	2.3
Headache pain in last month	0.7	1.1	3.4	1.8	1.0	1.7	0.6	0.6	0.5
Worry too long after embarrassment	0.7	1.2	3.2	1.6	0.7	1.8	0.3	0.5	1.5
Eye problems/disorders: None of the above	0.7	0.8	2.5	1.1	0.9	1.1	0.3	0.2	1.6
Friendships satisfaction	0.7	0.9	1.9	-1.1	-1.4	-1.0	-1.1	-1.0	-0.1
Hearing aid user	0.7	0.8	2.3	-0.7	-1.0	0.0	-1.5	-1.2	-0.7
Medication: Atorvastatin	0.7	0.8	3.7	-0.8	0.3	-0.7	0.7	0.6	-1.9
Ever smoked	0.7	1.2	2.8	-1.6	-0.8	-1.5	-0.2	-0.0	-1.7
Bipolar Disorder (2018)	0.6	1.0	1.4	-1.0	-1.2	-1.1	-1.0	-1.1	-1.0
Bipolar Disorder or Schizophrenia	0.6	1.4	3.1	1.8	1.5	1.5	1.0	1.0	0.4
Lupus	0.6	0.8	2.8	-1.6	-0.5	-1.7	-0.4	-0.4	0.2
Waist Hip Ratio (WHR)	0.6	2.6	6.6	-0.6	-2.2	-0.6	-2.6	-2.4	0.1
Chronotype (morning person)	0.6	1.3	2.4	-1.1	-1.3	-1.1	-1.6	-1.5	0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	-0.5	0.7	-0.8	1.0	1.0	-1.3
Medication for hormone replacement therapy	0.6	0.7	1.8	-0.9	0.3	-0.9	0.9	0.7	-1.3
Average weekly fortified wine intake	0.6	0.7	1.5	-0.2	-1.1	0.1	-1.2	-1.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	1.2	0.2	1.2	-0.7	-0.4	1.4
Serious illness, injury or assault to yourself	0.6	0.7	1.3	1.0	1.1	1.2	0.7	0.9	-0.0
Past tobacco smoking	0.6	1.1	2.8	1.7	0.5	1.5	-0.1	-0.2	1.4
Alcohol usually taken with meals	0.6	1.0	2.4	0.3	-1.0	0.3	-1.5	-1.5	1.1
Fluid intelligence score	0.6	1.3	2.3	-1.2	-1.4	-1.2	-1.4	-1.5	0.3
Prospective memory result	0.6	0.7	1.6	1.0	1.3	0.8	0.7	0.8	1.0
Peak expiratory flow (PEF)	0.6	1.4	3.9	-0.8	0.7	-0.9	1.4	1.4	-2.0
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	1.2	-0.4	1.4	-1.3	-1.3	0.9
Overall health rating	0.6	1.3	3.5	1.7	1.2	1.9	0.7	0.8	0.7
Illnesses of siblings: Diabetes	0.6	0.8	1.4	-0.9	-1.2	-1.2	-0.8	-0.9	0.4
Qualifications: nursing, teaching	0.6	1.0	2.1	-0.8	-1.3	-1.0	-1.1	-1.4	0.7
Number of self-reported non-cancer illnesses	0.6	1.1	3.6	1.4	0.6	1.3	0.3	0.0	1.9
Wears glasses or contact lenses	0.6	0.7	1.9	1.3	0.0	1.4	-0.7	-0.5	0.9
Heart disease (siblings)	0.6	0.7	1.8	0.5	1.0	0.5	1.1	1.4	0.7
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	1.0	1.2	1.0	1.1	1.3	0.8
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-0.6	-0.9	-0.9	-1.0	-1.0	0.5
Heel T-Score	0.5	3.7	7.8	-1.0	-1.9	-0.9	-2.8	-2.8	2.2
Supplements: Zinc	0.5	0.5	1.0	0.8	0.9	0.5	0.8	1.0	0.2
Father’s age at death	0.5	0.7	2.4	0.5	-0.4	0.6	-0.8	-0.9	1.5
Number of live births	0.5	0.7	1.8	0.4	0.9	0.1	1.3	1.4	-0.3
Pulse rate	0.5	0.8	2.2	-0.3	0.4	-0.5	1.5	1.5	-1.0
Noisy workplace	0.5	0.6	1.9	-0.0	-0.8	-0.2	-1.4	-1.3	0.3
Lung cancer (father)	0.5	0.5	1.4	0.7	-0.3	0.4	-1.2	-1.1	0.7
Illnesses of mother	0.5	0.6	2.0	1.1	0.5	1.4	0.1	0.2	0.6
Length of working week for main job	0.5	0.5	1.6	-1.3	-0.8	-1.0	-0.3	-0.3	-0.2
Health satisfaction	0.5	0.6	1.5	-1.0	-0.8	-1.2	-0.7	-0.7	0.5
Comparative height size at age 10	0.5	2.7	11.2	2.0	0.4	1.7	-0.4	-0.5	3.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.3	0.6	-0.5	1.2	1.0	-0.9
Diabetes diagnosed by doctor	0.5	0.8	1.3	-0.9	-1.1	-0.6	-1.1	-0.8	-1.0
Ever taken oral contraceptive pill	0.5	0.5	0.8	-0.8	-0.8	-0.9	-0.9	-0.8	-0.6
Medication: Bendroflumethiazide	0.5	0.7	2.2	1.1	0.4	1.3	-0.1	-0.0	1.5
Illnesses of father: High blood pressure	0.5	0.6	1.5	1.2	0.4	1.1	-0.1	-0.1	1.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	-0.2	-0.9	-0.3	-1.1	-1.0	1.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	-1.1	-1.0	-1.4	-1.1	-1.0	-0.1
Blood Eosinophil Count	0.4	2.8	5.2	-1.8	-2.3	-1.8	-1.9	-2.1	-0.2
Number of treatments/medications taken	0.4	0.7	1.3	0.5	-0.8	0.8	-1.1	-1.1	0.9
Medication: Co-codamol	0.4	0.4	1.4	-1.1	-0.1	-1.2	0.3	0.2	-0.5
Trunk fat percentage	0.4	1.5	3.7	0.2	1.3	0.3	1.9	1.8	-1.4
Townsend deprivation index at recruitment	0.4	0.5	1.5	0.4	0.9	0.4	0.7	0.7	1.2
Current tobacco smoking	0.4	0.6	0.9	1.0	0.9	0.8	0.8	0.8	-0.7
Maternal smoking around birth	0.4	0.6	1.8	-0.2	-0.9	-0.1	-1.4	-1.2	0.2
Body mass index (BMI)	0.4	1.6	3.3	-0.3	1.5	0.0	1.8	1.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	-0.3	-0.9	-0.0	-1.6	-1.5	0.7
Financial difficulties in last 2 years	0.4	0.5	1.2	-1.0	0.2	-1.1	0.5	0.4	-0.8
Heart attack	0.4	0.5	2.6	-0.2	0.2	-0.3	0.8	0.7	-1.6
Medication: Ramipril	0.4	0.5	1.3	-0.6	0.5	-0.6	1.1	1.0	-0.5
Arm fat mass (right)	0.4	1.5	3.0	-0.6	1.3	-0.3	1.7	1.7	-1.7
Pulse wave reflection index	0.4	0.5	1.1	0.8	1.1	1.0	0.1	0.3	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	0.8	1.0	0.9	0.6	0.7	-0.4
Birth weight	0.4	0.9	2.7	0.1	1.2	0.2	1.6	1.4	-0.6
Medication: Omeprazole	0.4	0.5	1.1	-1.0	-0.7	-0.7	-0.7	-0.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	0.8	0.9	0.7	0.7	0.8	-0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.4	-0.5	-0.9	-0.2	-1.0	-0.9	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.4	0.9	0.2	0.9	1.0	-0.2
Mineral and other dietary supplements	0.4	0.5	1.2	-0.2	-0.8	-0.4	-1.1	-1.1	0.7
Osteoporosis (self-reported)	0.4	0.5	1.1	0.5	0.5	0.0	1.1	1.0	0.9
Financial situation satisfaction	0.4	0.6	1.3	-0.4	-0.8	-0.2	-1.2	-1.1	0.6
Medication: Blood pressure	0.4	0.8	1.8	0.6	1.2	0.3	1.2	1.3	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.2	1.1	0.6	1.1	0.3	0.5	0.8
Leg fat percentage (left)	0.4	1.6	3.1	0.3	1.5	0.4	1.7	1.8	-1.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.7	-1.0	-0.5	-0.9	-0.9	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.0	-0.3	-0.1	-0.4	0.5	0.4	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-0.4	-0.9	-0.6	-1.0	-1.0	0.2
Leg fat mass (left)	0.4	1.5	3.0	-0.0	1.4	0.2	1.7	1.6	-1.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	-1.5	-0.9	-1.5	-0.8	-0.7	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.0	-0.4	-1.1	-0.2	-0.4	-0.6
Major Depression (MDD)	0.3	0.4	1.3	1.0	0.2	1.1	-0.3	-0.0	-0.6
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.4	0.6	0.5	0.9	0.9	-0.5
Mean Putamen Volume	0.3	0.4	1.0	0.5	-0.6	0.7	-1.0	-0.8	0.0
LDL Cholesterol	0.3	0.4	1.1	-1.1	-0.5	-0.9	-0.3	-0.2	-0.7
BMI	0.3	1.7	3.7	-1.0	1.1	-0.8	1.6	1.6	-1.9
Sensitivity / hurt feelings	0.3	0.5	1.4	1.2	0.2	1.2	-0.0	0.1	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.1	0.5	-0.0	0.7	-0.4	-0.4	1.5
Relative age of first facial hair	0.3	0.6	1.7	0.8	0.9	1.3	0.8	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.8	-0.4	-1.0	-0.1	-1.4	-1.3	0.4
High blood pressure (mother)	0.3	0.4	1.1	0.7	0.8	0.4	0.6	0.6	1.1
Trunk fat mass	0.3	1.2	2.9	-0.0	1.2	0.1	1.7	1.6	-1.1
Hearing difficulty/problems with background noise	0.3	0.4	1.6	0.3	-0.5	0.5	-0.7	-0.5	1.3
Pain all over the body in last month	0.3	0.3	1.2	0.7	0.2	0.7	0.2	0.3	1.1
Diabetes (self-reported)	0.3	0.4	1.8	-0.6	-0.6	-0.6	-0.3	-0.1	-1.4
Arm fat percentage (right)	0.3	1.4	3.8	-0.9	0.8	-0.6	1.4	1.4	-1.9
Hip circumference	0.3	1.4	3.2	-0.4	1.4	-0.1	1.8	1.8	-1.0
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	1.0	0.6	0.9	0.3	0.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.1	1.1	1.0	0.7	0.4	0.3	1.0
Body fat percentage	0.3	1.2	2.9	-0.2	1.0	-0.0	1.5	1.4	-1.7
Leg fat percentage (right)	0.3	1.1	2.6	0.1	1.2	0.3	1.4	1.4	-1.6
Whole body fat mass	0.3	1.3	2.8	-0.1	1.3	0.1	1.7	1.6	-1.5
Leg fat mass (right)	0.3	1.1	2.5	-0.1	1.1	0.1	1.4	1.3	-1.6
Smoking status: Previous	0.3	0.5	0.9	-0.9	0.1	-0.8	0.6	0.7	-0.9
Arm fat percentage (left)	0.3	1.1	3.5	-0.7	0.7	-0.4	1.2	1.2	-1.9
Back pain experienced in last month	0.3	0.5	2.1	-0.3	-0.6	-0.3	-0.7	-0.4	-1.4
Breast cancer (self-reported)	0.3	0.4	1.3	-1.1	-0.7	-0.8	-0.3	-0.3	-0.0
Smoking status: Current	0.3	0.5	0.8	0.8	0.9	0.7	0.7	0.7	-0.5
Arm fat mass (left)	0.3	1.3	2.5	-0.4	1.2	-0.2	1.6	1.6	-1.6
Arm fat-free mass (left)	0.3	1.5	3.5	-0.1	1.8	-0.1	1.9	1.8	-0.8
Irritability	0.3	0.5	1.0	0.6	0.7	0.6	0.9	1.0	0.3
Ever depressed for a whole week	0.3	0.4	1.1	0.6	-0.1	1.0	-0.6	-0.6	0.8
Supplements: Calcium	0.3	0.3	0.9	0.8	-0.0	1.0	-0.1	-0.0	0.6
HbA1C	0.2	0.2	0.5	0.7	0.5	0.5	0.0	0.3	-0.5
Neuroticism (2016)	0.2	0.2	0.8	0.6	0.1	0.9	0.1	0.3	-0.7
Blood Platelet Count	0.2	2.1	4.8	-0.1	1.5	-0.0	1.8	2.1	-2.2
Blood Red Count	0.2	2.2	5.6	-0.5	1.2	-0.3	1.9	2.1	-2.4
Blood White Count	0.2	1.8	6.0	-2.0	-0.6	-1.5	-0.2	0.0	-2.5
Systolic Blood Pressure	0.2	1.0	3.0	-0.1	1.0	-0.3	1.7	1.7	-0.1
Cardiovascular Disease	0.2	0.8	2.1	-0.2	1.0	-0.3	1.5	1.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	-0.6	-0.1	-0.5	0.4	0.5	-1.2
Hand grip strength (left)	0.2	0.5	1.6	-1.0	-0.1	-1.1	0.1	0.0	-1.3
Weight	0.2	0.9	2.2	-0.3	1.2	-0.1	1.5	1.4	-0.7
Impedance of arm (right)	0.2	1.0	2.3	-0.4	-1.5	-0.6	-1.2	-1.4	0.7
Impedance of arm (left)	0.2	0.9	2.4	-0.2	-1.6	-0.4	-1.2	-1.4	0.6
Exposure to tobacco smoke at home	0.2	0.3	1.1	0.2	-0.1	0.6	-0.6	-0.4	-1.1
Birth weight of first child	0.2	0.3	0.5	-0.6	-0.7	-0.5	-0.6	-0.6	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	0.2	-0.3	0.2	-0.8	-1.0	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	2.8	-0.2	-0.7	0.1	-0.8	-0.9	1.7
Arm fat-free mass (right)	0.2	0.9	2.0	0.2	1.4	0.1	1.4	1.3	-0.5
Comparative body size at age 10	0.2	0.6	1.5	-0.5	0.8	-0.5	1.2	1.0	-0.8
Age at first live birth	0.2	0.3	0.5	0.4	-0.6	0.6	-0.6	-0.6	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.4	0.5	0.4	0.4	0.5	0.7
Medication: Allopurinol	0.2	0.3	0.7	0.0	-0.5	-0.2	-0.8	-0.8	0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.2	-0.5	0.1	-0.7	-0.7	0.2
Arm predicted mass (right)	0.2	0.8	1.9	-0.1	1.3	-0.2	1.4	1.3	-0.8
Pulse rate, automated reading	0.2	0.8	2.1	-1.1	-0.3	-1.2	0.5	0.6	-1.5
Alcohol intake frequency.	0.2	0.5	1.1	-0.7	0.6	-0.7	1.1	0.9	-0.6
Number of full sisters	0.2	0.3	1.9	0.0	0.1	-0.3	0.1	0.3	-1.4
Chest pain or discomfort	0.2	0.3	0.8	-0.8	-0.3	-0.9	-0.4	-0.4	-0.3
Family relationship satisfaction	0.2	0.3	1.7	0.1	-0.0	0.3	-0.0	-0.1	1.3
Knee pain experienced in last month	0.2	0.4	0.9	0.9	0.1	1.0	-0.5	-0.3	0.8
Average weekly red wine intake	0.2	0.3	0.9	-0.4	-0.7	-0.4	-0.4	-0.4	-1.0
Medication for cholesterol	0.2	0.3	0.8	0.5	-0.5	0.6	-0.9	-0.9	0.2
Leg predicted mass (right)	0.2	0.8	2.1	-0.4	1.2	-0.2	1.5	1.3	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	-0.3	-0.1	-0.7	0.3	0.2	-1.0
Medication: Lisinopril	0.2	0.2	1.1	0.2	0.3	0.2	0.1	0.3	-1.0
Unable to work because of sickness or disability	0.2	0.3	0.9	0.4	0.5	0.6	0.3	0.2	0.9
Arm predicted mass (left)	0.2	1.0	2.5	-0.1	1.5	-0.1	1.6	1.5	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.2	-0.1	-0.3	-0.4	-0.6	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.3	-0.4	-0.0
Reaction Time	0.1	0.1	0.3	-0.4	-0.2	-0.0	0.5	0.6	0.2
Breast Cancer	0.1	0.1	0.5	0.5	0.2	0.7	0.1	0.3	0.2
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.2	0.4	0.3	0.3	0.0
HDL Cholesterol	0.1	0.1	0.3	-0.6	-0.2	-0.6	-0.2	-0.2	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	0.4	0.3	0.3	0.3	0.1
Triglycerides	0.1	0.2	0.5	0.6	0.2	0.7	-0.0	0.1	0.6
Height	0.1	2.4	4.9	-1.8	-1.8	-2.2	-1.3	-1.8	-0.2
Respiratory disease	0.1	0.3	0.9	0.4	-0.3	0.5	-0.7	-1.0	0.4
Lung FVC	0.1	0.3	1.0	0.5	0.1	1.0	-0.2	0.1	0.8
Average weekly spirits intake	0.1	0.2	0.5	-0.1	0.4	-0.1	0.3	0.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.4	0.1	0.4	-0.0	-0.1	0.6
Severe depression (siblings)	0.1	0.1	0.5	-0.2	-0.2	-0.4	-0.2	-0.1	-0.7
Impedance of leg (right)	0.1	0.6	1.4	0.8	-0.9	0.3	-1.1	-1.2	0.6
Leg fat-free mass (left)	0.1	0.7	1.7	-0.5	1.1	-0.3	1.3	1.2	-0.6
Relative age voice broke	0.1	0.1	0.5	-0.5	-0.7	-0.2	-0.3	-0.2	0.2
Taking other prescription medications	0.1	0.1	0.3	-0.4	-0.6	-0.0	-0.4	-0.4	0.4
Supplements: Glucosamine	0.1	0.2	0.4	0.5	-0.1	0.7	-0.4	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.1	-0.2	0.1	-0.3	-0.3	-0.5
Sitting height	0.1	0.8	1.5	-0.8	-0.8	-1.2	-0.7	-1.0	1.2
Impedance of leg (left)	0.1	0.5	1.0	1.0	-0.7	0.5	-0.8	-1.0	0.5
Leg predicted mass (left)	0.1	0.8	1.9	-0.5	1.1	-0.2	1.4	1.3	-0.7
Waist circumference	0.1	0.4	1.4	-0.2	0.5	0.1	0.7	0.7	-1.2
Number of incorrect matches in round	0.1	0.1	0.5	-0.3	0.0	-0.1	-0.1	0.1	-0.7
Forced vital capacity (FVC)	0.1	0.4	2.6	0.1	0.0	0.5	-0.0	-0.0	1.6
Qualifications: None of the above	0.1	0.2	0.5	-0.1	-0.4	0.3	-0.7	-0.5	-0.3
Trunk fat-free mass	0.1	0.3	0.9	-0.9	0.5	-0.9	0.5	0.4	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.9	-0.4	-0.1	-0.6	0.0	0.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	-0.2	-0.6	0.0	-0.7	-0.7	1.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.3	0.2	0.7	-0.2	0.0	-0.0
Trunk predicted mass	0.1	0.3	0.8	-0.9	0.4	-0.9	0.5	0.4	-0.2
Standing height	0.1	0.7	3.6	0.1	-0.5	-0.2	-0.6	-1.0	1.9
Breastfed as a baby	0.1	0.1	0.2	-0.1	0.5	-0.4	0.1	0.1	-0.5
Gout (self-reported)	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	-0.4	-0.3
Number of children fathered	0.1	0.1	0.3	0.1	-0.2	0.1	-0.3	-0.4	0.6
Pulse wave peak to peak time	0.1	0.1	0.3	-0.1	-0.2	-0.5	0.1	-0.1	0.3
Qualifications: College or University degree	0.1	0.2	0.6	-0.6	-0.5	-0.8	-0.2	-0.4	0.2
Mean time to correctly identify matches	0.1	0.2	1.0	-0.1	-0.4	0.3	-0.0	0.2	1.0
Age at last live birth	0.1	0.1	0.4	0.3	-0.3	0.6	-0.5	-0.4	-0.1
Medication: Aspirin	0.1	0.2	1.0	-0.1	-0.3	0.3	-0.4	0.0	-1.0
Whole body fat-free mass	0.1	0.5	1.1	-0.6	0.9	-0.5	1.0	0.9	-0.5
Leg fat-free mass (right)	0.1	0.8	2.0	-0.4	1.1	-0.2	1.4	1.3	-0.6
Loneliness, isolation	0.1	0.2	0.5	-0.1	0.7	-0.1	0.6	0.6	0.5
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.4	-0.1	0.6	-0.7	-0.2	-0.3
Medication: Aspirin	0.1	0.1	0.3	0.3	-0.0	0.5	-0.2	0.1	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	-0.2	-0.2	-0.4	-0.4	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.5	-0.5	-0.4	-0.4	-0.3	0.1
Whole body water mass	0.1	0.6	1.1	-0.7	0.9	-0.7	1.0	0.9	-0.6
Mother’s age at death	0.1	0.1	0.4	-0.3	-0.0	-0.2	0.6	0.5	-0.5
Basal metabolic rate	0.1	0.7	1.7	-0.6	1.1	-0.4	1.3	1.2	-0.6
Risk taking	0.1	0.2	0.3	0.5	0.4	0.4	0.5	0.4	0.0
Impedance of whole body	0.1	0.8	1.6	0.7	-1.1	0.3	-1.0	-1.2	1.0
Ovarian Cancer	0.0	0.0	0.1	-0.2	-0.2	-0.4	-0.0	0.1	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.8	0.5	0.6	0.3	0.4	0.2
Hair Pigment	0.0	0.1	0.3	-0.3	0.2	-0.1	0.6	0.4	-0.4
Tanning	0.0	0.4	0.7	-0.6	-0.8	-0.5	-0.9	-0.6	-0.7
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.0	0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.2	-0.2	0.0	-0.1	0.5	0.3	0.2
Hand grip strength (right)	0.0	0.1	0.6	-0.3	-0.3	-0.2	-0.2	-0.3	-0.8
Age when periods started (menarche)	0.0	0.0	0.1	-0.3	-0.0	-0.2	0.2	-0.1	0.3
Chronic bronchitis/emphysema (father)	0.0	0.0	0.2	-0.3	-0.2	-0.0	-0.4	-0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.6	-0.1	-0.0	0.1	0.1	0.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0	0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	-0.0	-0.3
Glaucoma (self-reported)	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.2	-0.4	0.0
Medication: Blood pressure	0.0	0.1	0.3	0.0	0.2	0.1	0.3	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	-0.2	-0.3	-0.2	-0.2	-0.4	0.5
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.2	-0.0	-0.0	0.0	-0.2

Hub : Genes

NOD2

Models

Trait associations