Hub : Genes

IDI1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.1390 0.0590 5.0e-03 -0.005 NA -0.006 NA -0.006 0.63000 NA 9.5e-01 NA 9.2e-01
2 METSIM Adipose 0.0552 0.0187 7.4e-05 0.024 0.029 0.028 0.03 0.029 0.00013 3.1e-05 3.7e-05 1.9e-05 2.8e-05
3 YFS Blood 0.0136 0.0070 1.4e-02 0.000 0.000 -0.001 0.00 0.004 0.33000 5.0e-01 9.7e-01 3.8e-01 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.3 2.0 3.3 0.0 -1.7 -1.8
Bipolar Disorder or Schizophrenia 0.2 0.6 1.2 0.5 -1.1 -0.6
Depressed Affect (Nagel 2018) 1.0 2.1 4.4 -1.3 2.1 0.4
Depression (Nagel 2018) 1.1 1.7 4.2 -2.0 0.9 0.2
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.0 0.8 -0.7 1.0
Neuroticism (Nagel 2018) 0.8 1.8 3.9 -1.0 2.0 0.8
Schizophrenia (2018) 0.1 0.3 0.5 0.6 -0.1 0.7
Schizophrenia vs Biploar Disorder 1.1 1.5 1.9 -0.9 1.3 1.4
Worry (Nagel 2018) 0.5 1.1 1.6 -1.0 1.3 1.0
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 -0.7 0.3 0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.5 0.7 0.0 0.4
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 -0.1 -0.2 0.3
Crohns Disease (2017) 0.1 0.1 0.3 0.2 -0.4 0.5
Irritable Bowel Disease (IBD) 0.4 1.1 2.1 -0.9 -1.4 -0.5
Ulcerative Colitis (UC) 1.3 2.5 3.6 -1.9 -1.4 -1.4
Major Depression (MDD) 0.6 0.8 1.5 -1.2 0.9 0.3
Reaction Time 1.5 2.9 8.1 -2.8 0.8 0.1
Verbal and Numeric Reasoning (VNR) 0.6 1.5 2.3 1.5 -0.2 1.5
Breast Cancer 0.3 0.7 1.9 0.3 1.4 0.4
Ovarian Cancer 0.8 1.1 2.7 -1.6 -0.3 -0.7
Prostate Cancer 5.5 7.7 22.2 4.7 -0.9 -0.5
Age at First Birth 0.8 1.2 2.7 -0.0 -0.9 -1.7
Bipolar Disorder (2011) 0.6 0.6 1.7 1.3 -0.3 0.2
Body Mass Index (BMI) (2010) 0.5 0.6 1.1 0.8 -0.4 -1.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 -0.1 -0.0 0.0
Crohns Disease (2012) 0.3 0.6 1.0 0.3 1.0 0.8
Mean Putamen Volume 0.3 0.4 1.1 0.0 0.1 -1.0
Fasting Glucose 0.3 0.4 0.6 -0.2 0.8 0.8
HbA1C 1.3 1.5 1.6 -1.2 1.3 1.2
HDL Cholesterol 1.7 2.8 5.1 0.6 -2.2 -1.7
LDL Cholesterol 0.1 0.2 0.6 0.3 -0.2 -0.8
Lupus 0.5 0.8 1.8 0.6 -1.3 -0.4
Neuroticism (2016) 0.7 1.0 1.6 -0.6 1.1 1.3
Primary Biliary Cirrhosis 1.4 1.9 5.2 0.6 -2.3 0.4
Rheumatoid Arthritis 0.5 0.7 0.9 -0.9 -1.0 -0.6
Schizophrenia (2014) 0.3 0.7 1.3 0.7 -1.1 -0.4
Triglycerides 0.5 0.8 1.1 0.7 -1.0 -1.0
Type 2 Diabetes (T2D) (2012) 2.1 2.5 5.6 -0.9 -1.0 -2.4
Ulcerative Colitis 0.5 0.7 1.6 -0.4 -1.3 -0.6
Blood Eosinophil Count 7.3 56.0 151.3 12.3 -2.6 3.2
Blood Platelet Count 0.0 0.6 1.1 1.0 -0.3 0.7
Blood Red Count 0.0 0.4 1.3 -0.1 -0.1 1.1
Blood White Count 0.5 3.8 9.5 3.1 -1.4 0.0
Heel T-Score 0.4 2.9 5.9 1.6 0.6 2.4
BMI 1.5 8.5 17.9 -0.2 -2.7 -4.2
Height 0.4 7.5 17.6 -4.2 2.2 0.3
Waist Hip Ratio (WHR) 0.2 0.8 1.6 -0.3 1.2 0.9
Systolic Blood Pressure 0.5 2.3 6.4 2.5 0.6 -0.3
Smoking Status 0.5 1.2 3.0 -1.7 0.2 -0.7
Allergy or Eczema 0.3 0.7 0.9 0.8 -0.7 1.0
Cardiovascular Disease 0.1 0.4 0.9 0.2 -0.5 -0.9
Hypothyroidism (self reported) 0.3 0.7 1.7 0.1 -1.3 0.5
Respiratory disease 1.4 3.2 5.1 -1.8 -1.2 -2.3
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.1 0.1 1.0 -1.0
Lung FEV1/FVC ratio 1.5 7.6 11.5 3.4 -3.1 -1.3
Lung FVC 1.3 6.6 12.8 1.3 2.3 3.6
Neuroticism 1.2 3.0 5.4 -1.3 2.3 1.3
Chronotype (morning person) 0.1 0.2 0.2 -0.5 -0.5 0.2
Hair Pigment 0.0 0.7 1.5 1.2 -0.2 -0.8
Tanning 0.1 1.2 2.2 -1.5 0.6 1.0
Hand grip strength (left) 0.2 0.4 1.1 -0.2 -1.1 0.2
Number of treatments/medications taken 0.2 0.4 1.2 0.3 -1.1 -0.1
Average weekly spirits intake 3.0 3.7 10.0 -3.2 1.0 -0.3
Sensitivity / hurt feelings 2.1 3.5 8.3 -1.1 2.9 1.1
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.7 -1.9 0.4 -0.8
Hearing difficulty/problems: Yes 0.4 0.6 1.1 -0.8 0.4 -1.0
Relative age of first facial hair 1.0 2.0 4.4 -2.1 -0.2 -1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 3.2 -1.8 0.1 -0.1
Ever used hormone-replacement therapy (HRT) 3.1 3.9 8.9 -3.0 1.5 -0.8
Ever had hysterectomy (womb removed) 2.0 2.3 5.7 -2.4 0.8 -0.8
Systolic blood pressure, automated reading 0.2 0.5 1.1 0.5 1.1 -0.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.5 -0.1 0.1
Angina 1.4 1.9 2.8 0.7 1.7 1.5
Medication for hormone replacement therapy 1.2 1.3 3.9 -2.0 -0.1 -0.0
Vitamin and mineral supplements 0.5 0.7 0.9 -0.9 0.7 -0.9
Supplements: Zinc 0.2 0.2 0.7 0.2 0.1 0.8
Medication: Co-codamol 0.5 0.6 1.1 0.2 0.8 1.1
Medication: Metformin 0.2 0.3 0.6 -0.1 0.7 -0.8
Diabetes (father) 0.8 1.0 1.8 -0.5 -1.4 -1.0
Diabetes (mother) 0.2 0.3 0.8 -0.9 -0.0 -0.2
Severe depression (siblings) 3.6 4.0 7.5 0.8 2.0 2.7
Pack years adult smoking proportion 1.9 2.8 5.4 -1.6 -0.7 -2.3
Impedance of leg (right) 1.2 5.9 10.7 -0.4 3.3 2.6
Leg fat-free mass (left) 0.4 2.3 4.0 0.0 -1.7 -2.0
Trunk fat percentage 0.0 0.1 0.2 0.5 0.3 0.1
Hand grip strength (right) 0.5 1.4 3.2 -0.8 -1.8 -0.6
Townsend deprivation index at recruitment 0.8 1.1 2.1 0.7 -0.9 -1.4
Current tobacco smoking 0.5 0.9 2.1 -0.6 0.4 -1.4
Average weekly fortified wine intake 0.2 0.2 0.5 0.7 -0.3 0.3
Maternal smoking around birth 0.2 0.3 0.7 0.2 0.8 -0.5
Fed-up feelings 1.1 2.0 2.9 -1.7 1.0 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.8 -0.9 -0.1 -0.4
Relative age voice broke 1.8 2.8 4.8 -2.2 -0.7 -1.7
Taking other prescription medications 0.3 0.5 0.9 -0.4 -0.9 -0.7
Age when periods started (menarche) 0.8 1.9 4.7 -2.2 -0.3 -1.0
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.6 -0.3 -0.5 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 6.3 2.5 0.0 0.6
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 2.9 -1.6 1.7 1.0
Qualifications: CSEs or equivalent 0.5 0.7 1.1 -1.1 0.3 -1.0
Serious illness, injury or assault to yourself 0.2 0.3 0.4 0.4 -0.6 0.5
High blood pressure 0.3 0.8 1.1 1.0 0.4 1.1
Hayfever, allergic rhinitis or eczema 0.6 1.4 2.7 1.0 -1.6 0.6
Multivitamins +/- minerals 2.3 2.9 6.1 2.5 -0.7 1.5
Stomach or abdominal pain in last month 1.7 2.1 4.4 -0.1 2.1 1.3
Supplements: Glucosamine 0.6 0.7 1.4 1.2 0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.8 -0.8 -0.9 -0.7
Medication: Atenolol 0.1 0.1 0.2 -0.1 0.2 -0.4
Medication: Levothyroxine sodium 0.6 1.1 1.9 -0.5 -1.4 -1.1
Sitting height 0.1 0.7 2.2 -0.1 1.5 0.2
Chronic bronchitis/emphysema (father) 1.0 1.1 1.3 -1.1 1.1 1.0
High blood pressure (mother) 4.3 6.0 7.6 1.8 2.8 2.7
Body mass index (BMI) 0.7 3.0 5.6 0.2 -1.8 -2.4
Impedance of leg (left) 1.1 5.5 10.6 -1.0 3.2 2.2
Leg predicted mass (left) 0.4 2.1 3.8 0.1 -1.6 -2.0
Trunk fat mass 0.0 0.1 0.4 0.2 0.1 -0.6
Waist circumference 0.3 1.1 2.8 -0.6 -0.3 -1.7
Number of incorrect matches in round 0.4 0.7 2.0 -1.4 -0.3 0.1
Past tobacco smoking 1.2 2.2 6.0 2.5 -0.7 -0.4
Alcohol usually taken with meals 1.7 2.7 7.8 2.8 -0.2 0.6
Nervous feelings 0.3 0.6 1.0 -0.9 0.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 4.1 -2.0 0.6 -0.7
Hearing difficulty/problems with background noise 0.4 0.7 1.5 -1.2 0.5 -0.5
Hair/balding pattern: Pattern 2 1.6 2.0 5.7 -2.4 0.1 0.5
Had menopause 1.0 1.2 2.5 -0.6 1.6 0.9
Had other major operations 1.2 1.5 2.4 1.1 -1.6 -1.0
Forced vital capacity (FVC) 0.4 1.5 3.8 -0.7 1.9 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 2.6 1.6 0.1 0.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.8 1.4 0.7 0.4
Qualifications: None of the above 0.7 1.5 3.3 -1.0 1.8 -0.4
Financial difficulties in last 2 years 0.1 0.1 0.2 0.5 -0.2 -0.3
Mouth/teeth dental problems 1.8 2.8 4.4 2.1 -0.1 2.0
Heart attack 2.2 2.8 5.9 0.8 1.4 2.4
Allergy 0.3 0.7 1.9 0.4 1.4 -0.0
Pain all over the body in last month 0.6 0.6 1.3 -1.2 0.4 0.5
Diabetes (self-reported) 0.1 0.1 0.3 -0.0 0.0 -0.6
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 4.2 2.1 -1.5 0.2
Medication: Ramipril 0.8 1.0 2.2 0.3 0.9 1.5
Medication: Simvastatin 0.4 0.5 1.0 -1.0 0.8 -0.0
Fluid intelligence score 0.1 0.3 0.7 0.1 0.3 0.8
Illnesses of siblings 1.4 1.9 3.6 0.9 -1.2 -1.9
Neuroticism score 0.6 1.3 2.1 -1.4 1.4 -0.1
Weight 0.3 1.7 4.0 -0.3 -1.0 -2.0
Impedance of arm (right) 0.9 4.4 7.2 -0.1 2.4 2.7
Arm fat percentage (right) 0.2 0.6 1.2 0.3 -0.8 -1.1
Trunk fat-free mass 0.3 2.0 4.6 -0.3 -1.1 -2.1
Hip circumference 0.5 2.2 5.0 0.3 -1.3 -2.2
Time employed in main current job 0.7 0.8 2.2 1.5 0.3 0.0
Alcohol intake versus 10 years previously 1.1 1.6 3.0 1.4 -1.7 -0.0
Father’s age at death 0.3 0.4 0.7 0.6 0.6 0.8
Worrier / anxious feelings 0.4 0.8 1.6 -0.2 0.9 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 6.5 -2.6 1.0 0.9
Falls in the last year 0.3 0.4 1.1 0.1 0.1 -1.0
Hair/balding pattern: Pattern 3 1.8 2.6 7.9 2.8 0.2 -0.1
Number of live births 2.4 3.5 5.7 -2.4 1.3 -1.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.5 0.5 0.7 0.0
Pulse rate 0.6 1.0 2.4 1.5 0.7 0.4
Happiness 2.1 2.5 6.7 -0.5 -0.8 -2.6
Noisy workplace 0.5 0.6 1.7 -1.3 -0.1 0.2
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.1 1.7 -1.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 3.9 4.4 6.2 1.4 2.3 2.5
Mouth/teeth dental problems: Dentures 1.1 1.8 3.0 -1.7 -0.5 -1.5
Asthma 1.2 2.4 3.8 -1.7 -0.7 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 0.9 0.8 0.9 1.0
Medication: Cholesterol lowering 1.2 1.9 2.5 -1.2 1.3 1.6
Depression (self-reported) 0.5 0.6 1.6 1.3 -0.5 0.1
Medication: Lansoprazole 0.4 0.4 1.0 -0.5 0.0 1.0
Prospective memory result 0.3 0.3 0.8 0.9 0.4 -0.1
Lung cancer (father) 0.7 0.9 2.1 -1.5 0.6 -0.3
Illnesses of mother 3.1 3.8 7.7 -0.7 -2.8 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.2 1.1 0.5 0.3
Pulse wave Arterial Stiffness index 2.2 2.6 7.7 2.8 0.1 0.1
Impedance of arm (left) 0.9 4.2 8.2 -0.3 2.1 2.9
Arm fat mass (right) 0.4 1.8 3.8 -0.0 -1.2 -1.9
Trunk predicted mass 0.3 1.9 4.4 -0.3 -1.1 -2.1
Standing height 0.2 1.8 3.1 -1.4 1.8 0.4
Length of working week for main job 0.1 0.1 0.3 0.4 0.0 0.5
Exposure to tobacco smoke at home 0.6 0.7 1.5 -0.2 0.7 1.2
Breastfed as a baby 0.2 0.3 0.5 0.6 -0.7 0.3
Tense / ‘highly strung’ 0.6 0.9 2.4 -0.6 1.6 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.5 -0.6 1.2 1.0
Hair/balding pattern: Pattern 4 0.5 1.2 2.7 -0.3 1.6 0.9
Birth weight of first child 0.2 0.4 0.7 -0.6 -0.3 -0.8
Peak expiratory flow (PEF) 0.5 1.1 2.1 1.0 -1.5 -0.4
Pulse wave reflection index 0.9 1.1 3.1 1.7 -0.3 0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.5 -0.7 1.1 -1.2
Loud music exposure frequency 0.8 0.9 1.9 -0.1 -1.4 0.9
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.2 1.1 -0.4 0.5
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 4.5 -1.2 0.9 -2.1
Blood clot in the leg (DVT) 0.6 0.8 1.6 -1.3 0.7 0.6
Medication: Paracetamol 0.4 0.7 1.7 0.6 0.3 1.3
Headache pain in last month 0.8 1.4 2.5 0.8 -1.6 -1.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.6 1.3 -1.0 -0.9
Glaucoma (self-reported) 1.3 1.6 2.5 -0.0 -1.6 -1.5
Gout (self-reported) 0.3 0.4 0.6 0.8 -0.5 0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 -0.8 -1.1 -0.0
Medication: Amlodipine 0.3 0.4 1.1 1.0 -0.4 -0.0
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.3 -1.1 -0.9 -1.0
Birth weight 0.3 0.6 1.4 -1.2 -0.5 0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.6 -0.1 0.9 1.3
High blood pressure (siblings) 3.6 5.2 9.9 -0.6 2.3 3.1
Forced vital capacity (FVC), Best measure 0.2 0.6 1.8 -0.1 1.4 0.3
Body fat percentage 0.0 0.1 0.2 0.4 0.2 -0.1
Leg fat percentage (right) 0.1 0.3 0.6 0.6 -0.0 -0.8
Arm fat-free mass (right) 0.5 2.4 5.3 -0.5 -1.3 -2.3
Exposure to tobacco smoke outside home 0.8 1.1 1.7 -1.2 0.2 -1.3
Comparative body size at age 10 1.1 3.1 5.2 1.4 -2.3 -1.4
Number of full brothers 0.9 1.1 1.8 -1.1 1.3 0.5
Worry too long after embarrassment 1.1 1.9 3.0 -0.6 1.5 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.4 0.7 -0.1 1.5
Wheeze or whistling in the chest in last year 0.7 1.2 2.2 -0.3 -1.5 -1.2
Number of children fathered 0.4 0.4 0.9 -0.4 0.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 0.6 0.7 -0.7 0.8
Age at first live birth 1.5 2.6 5.6 2.4 -1.3 -0.8
Pulse wave peak to peak time 2.3 2.7 8.2 -2.9 0.0 0.0
Health satisfaction 0.3 0.4 1.2 1.1 -0.3 -0.2
Shortness of breath walking on level ground 0.1 0.1 0.4 0.1 0.1 -0.6
Qualifications: College or University degree 1.3 4.2 6.4 2.5 -2.3 0.8
Eye problems/disorders: None of the above 0.5 0.5 1.3 0.1 -0.6 1.1
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.8 0.9 0.5 -0.4
Emphysema/chronic bronchitis 0.7 0.8 1.6 -0.3 0.9 1.3
Medication for pain relief, constipation, heartburn 0.3 0.5 1.4 -0.3 -0.3 -1.2
Neck or shoulder pain in last month 0.3 0.4 0.8 0.9 -0.4 -0.6
Medication: Blood pressure 0.5 0.8 1.8 -0.1 1.3 0.8
Angina (self-reported) 1.1 1.5 2.3 0.5 1.5 1.3
Migraine (self-reported) 1.1 1.4 2.9 1.7 0.5 1.0
Medication: Ibuprofen 0.1 0.2 0.5 0.1 0.7 -0.0
Medication: Allopurinol 0.2 0.3 0.6 -0.4 -0.8 -0.2
Medication: Omeprazole 0.9 1.0 1.8 0.8 -0.8 1.3
Medication: Seretide 50 evohaler 0.4 0.4 0.8 -0.9 -0.7 -0.3
Mean time to correctly identify matches 1.9 3.7 9.4 -3.1 1.2 0.3
Heart disease (mother) 0.4 0.5 1.4 -0.0 1.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.8 1.4 0.8 0.9
Whole body fat mass 0.1 0.3 1.0 -0.1 -0.2 -1.0
Leg fat mass (right) 0.3 1.0 2.7 -0.0 -0.5 -1.6
Arm predicted mass (right) 0.5 2.4 5.5 -0.4 -1.2 -2.3
Pulse rate, automated reading 0.1 0.2 0.3 0.5 -0.2 -0.6
Alcohol intake frequency. 0.4 0.9 2.7 1.6 0.2 0.2
Comparative height size at age 10 0.5 2.9 4.5 1.2 2.1 1.6
Number of full sisters 1.1 1.3 3.2 -1.8 0.5 -0.8
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.1 0.4 -0.5
Overall health rating 0.3 0.6 1.0 -1.0 0.9 0.2
Chest pain or discomfort 0.6 0.9 1.4 -1.2 1.0 0.5
Had major operations 0.4 0.4 0.8 -0.6 -0.9 -0.3
Age at last live birth 0.6 0.8 1.2 1.1 0.0 -1.1
Family relationship satisfaction 1.8 2.2 3.6 -0.3 -1.9 -1.7
Leg pain on walking 0.5 0.7 1.6 0.4 -0.5 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 -0.1 -0.4 -0.6
Commuting to job workplace: Car/motor vehicle 3.7 4.3 5.5 -1.6 -2.1 -2.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.8 -0.2 -1.7 -0.5
Medication: Aspirin 0.1 0.1 0.3 0.1 -0.3 -0.5
Supplements: Vitamin C 0.7 0.8 1.1 1.0 0.8 0.8
Knee pain experienced in last month 1.1 1.7 2.6 0.7 -1.6 -1.4
Hypertension (Self-reported) 0.1 0.4 0.6 0.5 0.6 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 -0.1 0.0 1.0
Illnesses of father: Heart disease 0.2 0.3 0.4 -0.6 -0.4 -0.5
Illnesses of siblings: Diabetes 0.2 0.3 0.7 -0.2 -0.2 -0.8
Smoking status: Previous 0.8 1.2 3.5 -1.9 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 0.1 0.6 0.5
Whole body fat-free mass 0.4 2.3 4.9 -0.2 -1.4 -2.2
Leg fat-free mass (right) 0.5 2.7 5.0 -0.2 -1.8 -2.2
Arm fat percentage (left) 0.2 0.8 1.2 0.4 -1.0 -1.1
Average weekly red wine intake 1.7 2.5 6.2 2.5 -0.7 0.8
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.2 -0.4 2.0 1.0
Mood swings 0.4 0.8 2.0 -0.6 1.4 0.0
Loneliness, isolation 0.5 0.7 1.6 0.0 -0.7 -1.2
Long-standing illness, disability or infirmity 1.3 1.9 2.6 -1.6 1.3 1.2
Ever had bowel cancer screening 2.7 3.2 4.5 -1.2 2.1 1.9
Diabetes diagnosed by doctor 0.3 0.4 1.0 -0.4 0.4 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.4 -0.6 -1.2 -1.0
Friendships satisfaction 0.0 0.0 0.0 -0.1 -0.2 0.2
Qualifications: nursing, teaching 1.4 2.2 4.3 1.5 -2.1 0.5
Commuting to job workplace: Walk 0.7 0.7 1.1 0.9 1.0 0.5
Eye problems/disorders: Cataract 0.2 0.2 0.4 -0.5 -0.1 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 4.5 -0.5 1.7 2.1
Medication for cholesterol 0.1 0.1 0.3 0.5 0.1 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.3 -0.6 -0.7
Back pain experienced in last month 0.4 0.6 1.3 -0.3 -0.8 -1.1
Mineral and other dietary supplements 2.5 3.4 5.7 -2.0 -0.6 -2.4
Breast cancer (self-reported) 0.8 0.9 1.3 0.9 1.1 0.9
Asthma (self-reported) 1.2 2.5 3.9 -1.7 -0.8 -2.0
Osteoporosis (self-reported) 0.4 0.6 1.0 0.5 1.0 0.7
Osteoarthritis (self-reported) 0.4 0.5 1.3 0.4 1.2 0.2
Medication: Aspirin 0.2 0.3 0.5 0.3 -0.7 -0.6
Medication: Gliclazide 1.3 1.5 2.6 0.5 -1.3 -1.6
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 0.9 0.1 0.6
Smoking status: Current 0.6 0.9 1.9 -0.9 0.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 5.5 2.4 0.5 0.9
Whole body water mass 0.4 2.3 5.1 -0.3 -1.3 -2.2
Leg predicted mass (right) 0.5 2.6 4.8 -0.2 -1.7 -2.2
Arm fat mass (left) 0.4 1.8 3.7 -0.2 -1.3 -1.9
Number of self-reported non-cancer illnesses 0.5 0.9 0.9 -0.9 1.0 0.9
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.3 0.6 -0.3
Miserableness 1.4 2.5 5.7 -2.4 1.2 -0.6
Guilty feelings 0.1 0.1 0.1 0.3 -0.3 0.4
Wears glasses or contact lenses 0.5 0.6 1.3 -0.1 -1.1 -0.7
Ever taken oral contraceptive pill 2.1 2.4 4.5 -0.7 -1.4 -2.1
Hearing aid user 1.6 1.8 2.9 -1.7 1.4 0.7
Mother’s age at death 0.7 0.9 1.2 0.7 1.1 1.0
Financial situation satisfaction 1.2 1.5 2.8 -1.7 -0.3 -1.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.6 1.3 -0.5 -0.6
Commuting to job workplace: Public transport 4.2 5.0 7.0 1.3 2.6 2.5
Eye problems/disorders: Glaucoma 1.3 1.6 2.8 0.5 -1.3 -1.7
Medication: Blood pressure 0.6 1.2 2.3 0.7 0.9 1.5
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.0 1.1 0.4 1.4
Supplements: Fish oil (including cod liver oil) 1.3 1.6 4.3 0.8 0.1 2.1
High cholesterol (Self-reported) 0.9 1.7 2.8 -1.7 1.2 0.9
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.7 -0.1 0.4
Medication: Paracetamol 0.1 0.1 0.2 -0.0 -0.3 0.4
Medication: Lisinopril 0.5 0.6 1.0 0.8 1.0 -0.6
Medication: Atorvastatin 3.9 4.8 7.0 -1.1 2.6 2.5
Illnesses of father: High blood pressure 1.3 1.6 2.6 1.6 -1.4 0.4
Alcohol drinker status: Never 0.6 0.7 1.0 1.0 -0.8 -0.7
Ever smoked 1.1 1.9 4.7 -2.2 0.7 0.8
Basal metabolic rate 0.4 2.3 5.2 -0.3 -1.3 -2.3
Leg fat percentage (left) 0.1 0.3 1.0 0.2 0.1 -1.0
Arm fat-free mass (left) 0.3 1.6 3.8 -0.3 -0.9 -2.0
Number of operations (self-reported) 0.1 0.1 0.2 0.2 -0.4 0.2
Average weekly beer plus cider intake 1.1 1.6 2.8 -1.7 -0.9 -1.2
Irritability 0.8 1.4 2.1 -1.0 1.5 1.0
Risk taking 0.2 0.3 0.6 0.8 0.3 0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.1 1.1 -0.9 0.6
Fractured/broken bones in last 5 years 1.4 1.8 2.6 1.0 -1.4 -1.6
Age started oral contraceptive pill 0.2 0.3 0.4 0.6 -0.6 0.3
Diastolic blood pressure, automated reading 1.1 3.5 8.2 2.9 -1.1 -1.1
Ever depressed for a whole week 1.1 1.4 3.1 1.8 1.0 0.4
Unable to work because of sickness or disability 0.2 0.3 0.7 0.1 0.0 -0.9
Commuting to job workplace: Cycle 1.0 1.2 2.6 0.9 0.3 1.6
Myopia 1.1 1.6 3.6 1.9 -0.8 0.9
Vascular/heart problems diagnosed by doctor 0.6 1.5 2.7 -1.3 -0.4 -1.7
Cholesterol lowering medication 0.1 0.2 0.4 -0.6 0.2 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.0 0.0 -1.1 1.4
Pain experienced in last month 0.7 1.1 1.7 -0.8 1.3 1.0
Supplements: Calcium 0.4 0.5 0.9 0.4 0.6 1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 0.5 -0.0 0.1
Heart attack/myocardial infarction (self-reported) 2.6 3.3 6.4 0.7 1.7 2.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.3 -1.5 0.8 0.5
Heart disease (siblings) 2.4 3.0 5.9 -1.2 1.3 2.4
Alcohol drinker status: Previous 4.9 5.6 9.5 -0.7 3.1 2.6
Pack years of smoking 1.9 2.8 5.1 -1.5 -1.0 -2.2
Impedance of whole body 1.1 5.7 9.4 -0.4 2.7 3.1
Leg fat mass (left) 0.3 1.1 3.0 -0.3 -0.4 -1.7
Arm predicted mass (left) 0.4 2.0 5.0 -0.4 -0.9 -2.2