Hub : Genes

IDI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1390	0.0590	5.0e-03	-0.005	NA	-0.006	NA	-0.006	0.63000	NA	9.5e-01	NA	9.2e-01
2	METSIM	Adipose	0.0552	0.0187	7.4e-05	0.024	0.029	0.028	0.03	0.029	0.00013	3.1e-05	3.7e-05	1.9e-05	2.8e-05
3	YFS	Blood	0.0136	0.0070	1.4e-02	0.000	0.000	-0.001	0.00	0.004	0.33000	5.0e-01	9.7e-01	3.8e-01	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.0	3.3	0.0	-1.7	-1.8
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	0.5	-1.1	-0.6
Depressed Affect (Nagel 2018)	1.0	2.1	4.4	-1.3	2.1	0.4
Depression (Nagel 2018)	1.1	1.7	4.2	-2.0	0.9	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.0	0.8	-0.7	1.0
Neuroticism (Nagel 2018)	0.8	1.8	3.9	-1.0	2.0	0.8
Schizophrenia (2018)	0.1	0.3	0.5	0.6	-0.1	0.7
Schizophrenia vs Biploar Disorder	1.1	1.5	1.9	-0.9	1.3	1.4
Worry (Nagel 2018)	0.5	1.1	1.6	-1.0	1.3	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.7	0.3	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	0.0	0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.1	-0.2	0.3
Crohns Disease (2017)	0.1	0.1	0.3	0.2	-0.4	0.5
Irritable Bowel Disease (IBD)	0.4	1.1	2.1	-0.9	-1.4	-0.5
Ulcerative Colitis (UC)	1.3	2.5	3.6	-1.9	-1.4	-1.4
Major Depression (MDD)	0.6	0.8	1.5	-1.2	0.9	0.3
Reaction Time	1.5	2.9	8.1	-2.8	0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.3	1.5	-0.2	1.5
Breast Cancer	0.3	0.7	1.9	0.3	1.4	0.4
Ovarian Cancer	0.8	1.1	2.7	-1.6	-0.3	-0.7
Prostate Cancer	5.5	7.7	22.2	4.7	-0.9	-0.5
Age at First Birth	0.8	1.2	2.7	-0.0	-0.9	-1.7
Bipolar Disorder (2011)	0.6	0.6	1.7	1.3	-0.3	0.2
Body Mass Index (BMI) (2010)	0.5	0.6	1.1	0.8	-0.4	-1.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.1	-0.0	0.0
Crohns Disease (2012)	0.3	0.6	1.0	0.3	1.0	0.8
Mean Putamen Volume	0.3	0.4	1.1	0.0	0.1	-1.0
Fasting Glucose	0.3	0.4	0.6	-0.2	0.8	0.8
HbA1C	1.3	1.5	1.6	-1.2	1.3	1.2
HDL Cholesterol	1.7	2.8	5.1	0.6	-2.2	-1.7
LDL Cholesterol	0.1	0.2	0.6	0.3	-0.2	-0.8
Lupus	0.5	0.8	1.8	0.6	-1.3	-0.4
Neuroticism (2016)	0.7	1.0	1.6	-0.6	1.1	1.3
Primary Biliary Cirrhosis	1.4	1.9	5.2	0.6	-2.3	0.4
Rheumatoid Arthritis	0.5	0.7	0.9	-0.9	-1.0	-0.6
Schizophrenia (2014)	0.3	0.7	1.3	0.7	-1.1	-0.4
Triglycerides	0.5	0.8	1.1	0.7	-1.0	-1.0
Type 2 Diabetes (T2D) (2012)	2.1	2.5	5.6	-0.9	-1.0	-2.4
Ulcerative Colitis	0.5	0.7	1.6	-0.4	-1.3	-0.6
Blood Eosinophil Count	7.3	56.0	151.3	12.3	-2.6	3.2
Blood Platelet Count	0.0	0.6	1.1	1.0	-0.3	0.7
Blood Red Count	0.0	0.4	1.3	-0.1	-0.1	1.1
Blood White Count	0.5	3.8	9.5	3.1	-1.4	0.0
Heel T-Score	0.4	2.9	5.9	1.6	0.6	2.4
BMI	1.5	8.5	17.9	-0.2	-2.7	-4.2
Height	0.4	7.5	17.6	-4.2	2.2	0.3
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.3	1.2	0.9
Systolic Blood Pressure	0.5	2.3	6.4	2.5	0.6	-0.3
Smoking Status	0.5	1.2	3.0	-1.7	0.2	-0.7
Allergy or Eczema	0.3	0.7	0.9	0.8	-0.7	1.0
Cardiovascular Disease	0.1	0.4	0.9	0.2	-0.5	-0.9
Hypothyroidism (self reported)	0.3	0.7	1.7	0.1	-1.3	0.5
Respiratory disease	1.4	3.2	5.1	-1.8	-1.2	-2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.1	0.1	1.0	-1.0
Lung FEV1/FVC ratio	1.5	7.6	11.5	3.4	-3.1	-1.3
Lung FVC	1.3	6.6	12.8	1.3	2.3	3.6
Neuroticism	1.2	3.0	5.4	-1.3	2.3	1.3
Chronotype (morning person)	0.1	0.2	0.2	-0.5	-0.5	0.2
Hair Pigment	0.0	0.7	1.5	1.2	-0.2	-0.8
Tanning	0.1	1.2	2.2	-1.5	0.6	1.0
Hand grip strength (left)	0.2	0.4	1.1	-0.2	-1.1	0.2
Number of treatments/medications taken	0.2	0.4	1.2	0.3	-1.1	-0.1
Average weekly spirits intake	3.0	3.7	10.0	-3.2	1.0	-0.3
Sensitivity / hurt feelings	2.1	3.5	8.3	-1.1	2.9	1.1
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.7	-1.9	0.4	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.1	-0.8	0.4	-1.0
Relative age of first facial hair	1.0	2.0	4.4	-2.1	-0.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.2	-1.8	0.1	-0.1
Ever used hormone-replacement therapy (HRT)	3.1	3.9	8.9	-3.0	1.5	-0.8
Ever had hysterectomy (womb removed)	2.0	2.3	5.7	-2.4	0.8	-0.8
Systolic blood pressure, automated reading	0.2	0.5	1.1	0.5	1.1	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.5	-0.1	0.1
Angina	1.4	1.9	2.8	0.7	1.7	1.5
Medication for hormone replacement therapy	1.2	1.3	3.9	-2.0	-0.1	-0.0
Vitamin and mineral supplements	0.5	0.7	0.9	-0.9	0.7	-0.9
Supplements: Zinc	0.2	0.2	0.7	0.2	0.1	0.8
Medication: Co-codamol	0.5	0.6	1.1	0.2	0.8	1.1
Medication: Metformin	0.2	0.3	0.6	-0.1	0.7	-0.8
Diabetes (father)	0.8	1.0	1.8	-0.5	-1.4	-1.0
Diabetes (mother)	0.2	0.3	0.8	-0.9	-0.0	-0.2
Severe depression (siblings)	3.6	4.0	7.5	0.8	2.0	2.7
Pack years adult smoking proportion	1.9	2.8	5.4	-1.6	-0.7	-2.3
Impedance of leg (right)	1.2	5.9	10.7	-0.4	3.3	2.6
Leg fat-free mass (left)	0.4	2.3	4.0	0.0	-1.7	-2.0
Trunk fat percentage	0.0	0.1	0.2	0.5	0.3	0.1
Hand grip strength (right)	0.5	1.4	3.2	-0.8	-1.8	-0.6
Townsend deprivation index at recruitment	0.8	1.1	2.1	0.7	-0.9	-1.4
Current tobacco smoking	0.5	0.9	2.1	-0.6	0.4	-1.4
Average weekly fortified wine intake	0.2	0.2	0.5	0.7	-0.3	0.3
Maternal smoking around birth	0.2	0.3	0.7	0.2	0.8	-0.5
Fed-up feelings	1.1	2.0	2.9	-1.7	1.0	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.9	-0.1	-0.4
Relative age voice broke	1.8	2.8	4.8	-2.2	-0.7	-1.7
Taking other prescription medications	0.3	0.5	0.9	-0.4	-0.9	-0.7
Age when periods started (menarche)	0.8	1.9	4.7	-2.2	-0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.6	-0.3	-0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.3	2.5	0.0	0.6
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	2.9	-1.6	1.7	1.0
Qualifications: CSEs or equivalent	0.5	0.7	1.1	-1.1	0.3	-1.0
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.4	-0.6	0.5
High blood pressure	0.3	0.8	1.1	1.0	0.4	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.7	1.0	-1.6	0.6
Multivitamins +/- minerals	2.3	2.9	6.1	2.5	-0.7	1.5
Stomach or abdominal pain in last month	1.7	2.1	4.4	-0.1	2.1	1.3
Supplements: Glucosamine	0.6	0.7	1.4	1.2	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	-0.8	-0.9	-0.7
Medication: Atenolol	0.1	0.1	0.2	-0.1	0.2	-0.4
Medication: Levothyroxine sodium	0.6	1.1	1.9	-0.5	-1.4	-1.1
Sitting height	0.1	0.7	2.2	-0.1	1.5	0.2
Chronic bronchitis/emphysema (father)	1.0	1.1	1.3	-1.1	1.1	1.0
High blood pressure (mother)	4.3	6.0	7.6	1.8	2.8	2.7
Body mass index (BMI)	0.7	3.0	5.6	0.2	-1.8	-2.4
Impedance of leg (left)	1.1	5.5	10.6	-1.0	3.2	2.2
Leg predicted mass (left)	0.4	2.1	3.8	0.1	-1.6	-2.0
Trunk fat mass	0.0	0.1	0.4	0.2	0.1	-0.6
Waist circumference	0.3	1.1	2.8	-0.6	-0.3	-1.7
Number of incorrect matches in round	0.4	0.7	2.0	-1.4	-0.3	0.1
Past tobacco smoking	1.2	2.2	6.0	2.5	-0.7	-0.4
Alcohol usually taken with meals	1.7	2.7	7.8	2.8	-0.2	0.6
Nervous feelings	0.3	0.6	1.0	-0.9	0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.1	-2.0	0.6	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-1.2	0.5	-0.5
Hair/balding pattern: Pattern 2	1.6	2.0	5.7	-2.4	0.1	0.5
Had menopause	1.0	1.2	2.5	-0.6	1.6	0.9
Had other major operations	1.2	1.5	2.4	1.1	-1.6	-1.0
Forced vital capacity (FVC)	0.4	1.5	3.8	-0.7	1.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.6	1.6	0.1	0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	1.4	0.7	0.4
Qualifications: None of the above	0.7	1.5	3.3	-1.0	1.8	-0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	0.5	-0.2	-0.3
Mouth/teeth dental problems	1.8	2.8	4.4	2.1	-0.1	2.0
Heart attack	2.2	2.8	5.9	0.8	1.4	2.4
Allergy	0.3	0.7	1.9	0.4	1.4	-0.0
Pain all over the body in last month	0.6	0.6	1.3	-1.2	0.4	0.5
Diabetes (self-reported)	0.1	0.1	0.3	-0.0	0.0	-0.6
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	4.2	2.1	-1.5	0.2
Medication: Ramipril	0.8	1.0	2.2	0.3	0.9	1.5
Medication: Simvastatin	0.4	0.5	1.0	-1.0	0.8	-0.0
Fluid intelligence score	0.1	0.3	0.7	0.1	0.3	0.8
Illnesses of siblings	1.4	1.9	3.6	0.9	-1.2	-1.9
Neuroticism score	0.6	1.3	2.1	-1.4	1.4	-0.1
Weight	0.3	1.7	4.0	-0.3	-1.0	-2.0
Impedance of arm (right)	0.9	4.4	7.2	-0.1	2.4	2.7
Arm fat percentage (right)	0.2	0.6	1.2	0.3	-0.8	-1.1
Trunk fat-free mass	0.3	2.0	4.6	-0.3	-1.1	-2.1
Hip circumference	0.5	2.2	5.0	0.3	-1.3	-2.2
Time employed in main current job	0.7	0.8	2.2	1.5	0.3	0.0
Alcohol intake versus 10 years previously	1.1	1.6	3.0	1.4	-1.7	-0.0
Father’s age at death	0.3	0.4	0.7	0.6	0.6	0.8
Worrier / anxious feelings	0.4	0.8	1.6	-0.2	0.9	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.5	-2.6	1.0	0.9
Falls in the last year	0.3	0.4	1.1	0.1	0.1	-1.0
Hair/balding pattern: Pattern 3	1.8	2.6	7.9	2.8	0.2	-0.1
Number of live births	2.4	3.5	5.7	-2.4	1.3	-1.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	0.5	0.7	0.0
Pulse rate	0.6	1.0	2.4	1.5	0.7	0.4
Happiness	2.1	2.5	6.7	-0.5	-0.8	-2.6
Noisy workplace	0.5	0.6	1.7	-1.3	-0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.1	1.7	-1.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.4	6.2	1.4	2.3	2.5
Mouth/teeth dental problems: Dentures	1.1	1.8	3.0	-1.7	-0.5	-1.5
Asthma	1.2	2.4	3.8	-1.7	-0.7	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	0.9	0.8	0.9	1.0
Medication: Cholesterol lowering	1.2	1.9	2.5	-1.2	1.3	1.6
Depression (self-reported)	0.5	0.6	1.6	1.3	-0.5	0.1
Medication: Lansoprazole	0.4	0.4	1.0	-0.5	0.0	1.0
Prospective memory result	0.3	0.3	0.8	0.9	0.4	-0.1
Lung cancer (father)	0.7	0.9	2.1	-1.5	0.6	-0.3
Illnesses of mother	3.1	3.8	7.7	-0.7	-2.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.2	1.1	0.5	0.3
Pulse wave Arterial Stiffness index	2.2	2.6	7.7	2.8	0.1	0.1
Impedance of arm (left)	0.9	4.2	8.2	-0.3	2.1	2.9
Arm fat mass (right)	0.4	1.8	3.8	-0.0	-1.2	-1.9
Trunk predicted mass	0.3	1.9	4.4	-0.3	-1.1	-2.1
Standing height	0.2	1.8	3.1	-1.4	1.8	0.4
Length of working week for main job	0.1	0.1	0.3	0.4	0.0	0.5
Exposure to tobacco smoke at home	0.6	0.7	1.5	-0.2	0.7	1.2
Breastfed as a baby	0.2	0.3	0.5	0.6	-0.7	0.3
Tense / ‘highly strung’	0.6	0.9	2.4	-0.6	1.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.5	-0.6	1.2	1.0
Hair/balding pattern: Pattern 4	0.5	1.2	2.7	-0.3	1.6	0.9
Birth weight of first child	0.2	0.4	0.7	-0.6	-0.3	-0.8
Peak expiratory flow (PEF)	0.5	1.1	2.1	1.0	-1.5	-0.4
Pulse wave reflection index	0.9	1.1	3.1	1.7	-0.3	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.5	-0.7	1.1	-1.2
Loud music exposure frequency	0.8	0.9	1.9	-0.1	-1.4	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	1.1	-0.4	0.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.5	-1.2	0.9	-2.1
Blood clot in the leg (DVT)	0.6	0.8	1.6	-1.3	0.7	0.6
Medication: Paracetamol	0.4	0.7	1.7	0.6	0.3	1.3
Headache pain in last month	0.8	1.4	2.5	0.8	-1.6	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.6	1.3	-1.0	-0.9
Glaucoma (self-reported)	1.3	1.6	2.5	-0.0	-1.6	-1.5
Gout (self-reported)	0.3	0.4	0.6	0.8	-0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	-0.8	-1.1	-0.0
Medication: Amlodipine	0.3	0.4	1.1	1.0	-0.4	-0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.3	-1.1	-0.9	-1.0
Birth weight	0.3	0.6	1.4	-1.2	-0.5	0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	-0.1	0.9	1.3
High blood pressure (siblings)	3.6	5.2	9.9	-0.6	2.3	3.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.8	-0.1	1.4	0.3
Body fat percentage	0.0	0.1	0.2	0.4	0.2	-0.1
Leg fat percentage (right)	0.1	0.3	0.6	0.6	-0.0	-0.8
Arm fat-free mass (right)	0.5	2.4	5.3	-0.5	-1.3	-2.3
Exposure to tobacco smoke outside home	0.8	1.1	1.7	-1.2	0.2	-1.3
Comparative body size at age 10	1.1	3.1	5.2	1.4	-2.3	-1.4
Number of full brothers	0.9	1.1	1.8	-1.1	1.3	0.5
Worry too long after embarrassment	1.1	1.9	3.0	-0.6	1.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.4	0.7	-0.1	1.5
Wheeze or whistling in the chest in last year	0.7	1.2	2.2	-0.3	-1.5	-1.2
Number of children fathered	0.4	0.4	0.9	-0.4	0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	0.6	0.7	-0.7	0.8
Age at first live birth	1.5	2.6	5.6	2.4	-1.3	-0.8
Pulse wave peak to peak time	2.3	2.7	8.2	-2.9	0.0	0.0
Health satisfaction	0.3	0.4	1.2	1.1	-0.3	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.4	0.1	0.1	-0.6
Qualifications: College or University degree	1.3	4.2	6.4	2.5	-2.3	0.8
Eye problems/disorders: None of the above	0.5	0.5	1.3	0.1	-0.6	1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.9	0.5	-0.4
Emphysema/chronic bronchitis	0.7	0.8	1.6	-0.3	0.9	1.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	-0.3	-0.3	-1.2
Neck or shoulder pain in last month	0.3	0.4	0.8	0.9	-0.4	-0.6
Medication: Blood pressure	0.5	0.8	1.8	-0.1	1.3	0.8
Angina (self-reported)	1.1	1.5	2.3	0.5	1.5	1.3
Migraine (self-reported)	1.1	1.4	2.9	1.7	0.5	1.0
Medication: Ibuprofen	0.1	0.2	0.5	0.1	0.7	-0.0
Medication: Allopurinol	0.2	0.3	0.6	-0.4	-0.8	-0.2
Medication: Omeprazole	0.9	1.0	1.8	0.8	-0.8	1.3
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.9	-0.7	-0.3
Mean time to correctly identify matches	1.9	3.7	9.4	-3.1	1.2	0.3
Heart disease (mother)	0.4	0.5	1.4	-0.0	1.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.8	1.4	0.8	0.9
Whole body fat mass	0.1	0.3	1.0	-0.1	-0.2	-1.0
Leg fat mass (right)	0.3	1.0	2.7	-0.0	-0.5	-1.6
Arm predicted mass (right)	0.5	2.4	5.5	-0.4	-1.2	-2.3
Pulse rate, automated reading	0.1	0.2	0.3	0.5	-0.2	-0.6
Alcohol intake frequency.	0.4	0.9	2.7	1.6	0.2	0.2
Comparative height size at age 10	0.5	2.9	4.5	1.2	2.1	1.6
Number of full sisters	1.1	1.3	3.2	-1.8	0.5	-0.8
Suffer from ‘nerves’	0.1	0.1	0.2	-0.1	0.4	-0.5
Overall health rating	0.3	0.6	1.0	-1.0	0.9	0.2
Chest pain or discomfort	0.6	0.9	1.4	-1.2	1.0	0.5
Had major operations	0.4	0.4	0.8	-0.6	-0.9	-0.3
Age at last live birth	0.6	0.8	1.2	1.1	0.0	-1.1
Family relationship satisfaction	1.8	2.2	3.6	-0.3	-1.9	-1.7
Leg pain on walking	0.5	0.7	1.6	0.4	-0.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.1	-0.4	-0.6
Commuting to job workplace: Car/motor vehicle	3.7	4.3	5.5	-1.6	-2.1	-2.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.8	-0.2	-1.7	-0.5
Medication: Aspirin	0.1	0.1	0.3	0.1	-0.3	-0.5
Supplements: Vitamin C	0.7	0.8	1.1	1.0	0.8	0.8
Knee pain experienced in last month	1.1	1.7	2.6	0.7	-1.6	-1.4
Hypertension (Self-reported)	0.1	0.4	0.6	0.5	0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-0.1	0.0	1.0
Illnesses of father: Heart disease	0.2	0.3	0.4	-0.6	-0.4	-0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.2	-0.2	-0.8
Smoking status: Previous	0.8	1.2	3.5	-1.9	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.1	0.6	0.5
Whole body fat-free mass	0.4	2.3	4.9	-0.2	-1.4	-2.2
Leg fat-free mass (right)	0.5	2.7	5.0	-0.2	-1.8	-2.2
Arm fat percentage (left)	0.2	0.8	1.2	0.4	-1.0	-1.1
Average weekly red wine intake	1.7	2.5	6.2	2.5	-0.7	0.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.2	-0.4	2.0	1.0
Mood swings	0.4	0.8	2.0	-0.6	1.4	0.0
Loneliness, isolation	0.5	0.7	1.6	0.0	-0.7	-1.2
Long-standing illness, disability or infirmity	1.3	1.9	2.6	-1.6	1.3	1.2
Ever had bowel cancer screening	2.7	3.2	4.5	-1.2	2.1	1.9
Diabetes diagnosed by doctor	0.3	0.4	1.0	-0.4	0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.4	-0.6	-1.2	-1.0
Friendships satisfaction	0.0	0.0	0.0	-0.1	-0.2	0.2
Qualifications: nursing, teaching	1.4	2.2	4.3	1.5	-2.1	0.5
Commuting to job workplace: Walk	0.7	0.7	1.1	0.9	1.0	0.5
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.5	-0.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	4.5	-0.5	1.7	2.1
Medication for cholesterol	0.1	0.1	0.3	0.5	0.1	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.3	-0.6	-0.7
Back pain experienced in last month	0.4	0.6	1.3	-0.3	-0.8	-1.1
Mineral and other dietary supplements	2.5	3.4	5.7	-2.0	-0.6	-2.4
Breast cancer (self-reported)	0.8	0.9	1.3	0.9	1.1	0.9
Asthma (self-reported)	1.2	2.5	3.9	-1.7	-0.8	-2.0
Osteoporosis (self-reported)	0.4	0.6	1.0	0.5	1.0	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.4	1.2	0.2
Medication: Aspirin	0.2	0.3	0.5	0.3	-0.7	-0.6
Medication: Gliclazide	1.3	1.5	2.6	0.5	-1.3	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.9	0.1	0.6
Smoking status: Current	0.6	0.9	1.9	-0.9	0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.5	2.4	0.5	0.9
Whole body water mass	0.4	2.3	5.1	-0.3	-1.3	-2.2
Leg predicted mass (right)	0.5	2.6	4.8	-0.2	-1.7	-2.2
Arm fat mass (left)	0.4	1.8	3.7	-0.2	-1.3	-1.9
Number of self-reported non-cancer illnesses	0.5	0.9	0.9	-0.9	1.0	0.9
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.3	0.6	-0.3
Miserableness	1.4	2.5	5.7	-2.4	1.2	-0.6
Guilty feelings	0.1	0.1	0.1	0.3	-0.3	0.4
Wears glasses or contact lenses	0.5	0.6	1.3	-0.1	-1.1	-0.7
Ever taken oral contraceptive pill	2.1	2.4	4.5	-0.7	-1.4	-2.1
Hearing aid user	1.6	1.8	2.9	-1.7	1.4	0.7
Mother’s age at death	0.7	0.9	1.2	0.7	1.1	1.0
Financial situation satisfaction	1.2	1.5	2.8	-1.7	-0.3	-1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	1.3	-0.5	-0.6
Commuting to job workplace: Public transport	4.2	5.0	7.0	1.3	2.6	2.5
Eye problems/disorders: Glaucoma	1.3	1.6	2.8	0.5	-1.3	-1.7
Medication: Blood pressure	0.6	1.2	2.3	0.7	0.9	1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	1.1	0.4	1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.6	4.3	0.8	0.1	2.1
High cholesterol (Self-reported)	0.9	1.7	2.8	-1.7	1.2	0.9
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.7	-0.1	0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.0	-0.3	0.4
Medication: Lisinopril	0.5	0.6	1.0	0.8	1.0	-0.6
Medication: Atorvastatin	3.9	4.8	7.0	-1.1	2.6	2.5
Illnesses of father: High blood pressure	1.3	1.6	2.6	1.6	-1.4	0.4
Alcohol drinker status: Never	0.6	0.7	1.0	1.0	-0.8	-0.7
Ever smoked	1.1	1.9	4.7	-2.2	0.7	0.8
Basal metabolic rate	0.4	2.3	5.2	-0.3	-1.3	-2.3
Leg fat percentage (left)	0.1	0.3	1.0	0.2	0.1	-1.0
Arm fat-free mass (left)	0.3	1.6	3.8	-0.3	-0.9	-2.0
Number of operations (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.2
Average weekly beer plus cider intake	1.1	1.6	2.8	-1.7	-0.9	-1.2
Irritability	0.8	1.4	2.1	-1.0	1.5	1.0
Risk taking	0.2	0.3	0.6	0.8	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	1.1	-0.9	0.6
Fractured/broken bones in last 5 years	1.4	1.8	2.6	1.0	-1.4	-1.6
Age started oral contraceptive pill	0.2	0.3	0.4	0.6	-0.6	0.3
Diastolic blood pressure, automated reading	1.1	3.5	8.2	2.9	-1.1	-1.1
Ever depressed for a whole week	1.1	1.4	3.1	1.8	1.0	0.4
Unable to work because of sickness or disability	0.2	0.3	0.7	0.1	0.0	-0.9
Commuting to job workplace: Cycle	1.0	1.2	2.6	0.9	0.3	1.6
Myopia	1.1	1.6	3.6	1.9	-0.8	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.7	-1.3	-0.4	-1.7
Cholesterol lowering medication	0.1	0.2	0.4	-0.6	0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	0.0	-1.1	1.4
Pain experienced in last month	0.7	1.1	1.7	-0.8	1.3	1.0
Supplements: Calcium	0.4	0.5	0.9	0.4	0.6	1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.5	-0.0	0.1
Heart attack/myocardial infarction (self-reported)	2.6	3.3	6.4	0.7	1.7	2.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.3	-1.5	0.8	0.5
Heart disease (siblings)	2.4	3.0	5.9	-1.2	1.3	2.4
Alcohol drinker status: Previous	4.9	5.6	9.5	-0.7	3.1	2.6
Pack years of smoking	1.9	2.8	5.1	-1.5	-1.0	-2.2
Impedance of whole body	1.1	5.7	9.4	-0.4	2.7	3.1
Leg fat mass (left)	0.3	1.1	3.0	-0.3	-0.4	-1.7
Arm predicted mass (left)	0.4	2.0	5.0	-0.4	-0.9	-2.2