Hub : Genes

LARP4B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2077	0.0693	8.1e-04	0.093	NA	0.113	NA	0.114	3.2e-04	NA	7.5e-05	NA	6.8e-05
2	GTEx	Brain Cortex	0.3140	0.0950	2.8e-03	0.034	NA	0.150	NA	0.149	4.1e-02	NA	6.3e-05	NA	6.7e-05
3	GTEx	Cells Transformed fibroblasts	0.1130	0.0440	6.8e-03	-0.004	NA	-0.002	NA	-0.004	8.3e-01	NA	4.6e-01	NA	9.5e-01
4	GTEx	Esophagus Muscularis	0.2020	0.0580	6.5e-05	0.086	NA	0.118	NA	0.144	6.6e-06	NA	1.3e-07	NA	4.6e-09
5	METSIM	Adipose	0.0686	0.0274	1.0e-03	0.013	0.023	0.014	0.025	0.019	4.1e-03	2.0e-04	2.8e-03	1.1e-04	6.9e-04
6	YFS	Blood	0.0374	0.0114	1.3e-06	0.012	0.015	0.018	0.017	0.017	6.0e-05	8.5e-06	9.7e-07	1.5e-06	2.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.8	7.6	-1.0	2.8	0.5	0.9	0.9	0.7
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-0.7	0.4	0.3	-1.0	0.7	-1.1
Depressed Affect (Nagel 2018)	0.8	1.8	5.4	2.3	0.4	1.5	0.4	-1.2	1.2
Depression (Nagel 2018)	2.0	3.0	10.0	3.2	-1.2	-0.7	-1.6	-1.9	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.0	9.0	0.2	1.5	0.8	0.5	3.0	0.4
Neuroticism (Nagel 2018)	0.8	1.8	5.1	2.3	0.6	0.7	-0.9	-1.9	0.4
Schizophrenia (2018)	0.8	1.8	3.9	-0.1	-1.7	-0.0	-2.0	0.2	-2.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.7	-0.9	-0.2	-1.2	0.4	-0.5
Worry (Nagel 2018)	0.7	1.5	3.4	1.7	0.6	0.1	-1.6	-1.8	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	0.5	1.1	1.3	0.2	-0.5	0.7
Alzheimer’s Disease (in father)	0.3	0.4	1.2	-1.1	0.5	0.7	0.2	-0.1	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.4	1.2	0.7	0.2	-0.3	0.4
Crohns Disease (2017)	0.5	1.1	2.6	0.3	-0.9	-0.8	-1.5	0.2	-1.6
Irritable Bowel Disease (IBD)	1.4	3.3	10.0	0.7	-2.1	-1.7	-3.2	-1.0	-1.1
Ulcerative Colitis (UC)	1.4	2.5	7.0	1.3	-1.8	-0.9	-2.6	-1.6	0.5
Major Depression (MDD)	0.6	0.8	2.5	0.1	1.6	0.2	0.4	-0.3	1.3
Reaction Time	1.2	2.3	6.1	1.1	-0.5	-0.2	-0.9	-2.5	2.4
Verbal and Numeric Reasoning (VNR)	0.7	1.8	9.0	-0.2	0.7	-0.4	-0.8	3.0	-0.4
Breast Cancer	0.3	0.8	2.8	-0.0	0.7	0.2	1.7	-0.8	0.8
Ovarian Cancer	0.6	0.7	3.0	1.7	-0.3	-0.6	0.4	0.9	-0.0
Prostate Cancer	3.1	4.4	14.2	-3.8	0.2	-0.0	0.9	0.0	-3.4
Age at First Birth	0.7	1.0	3.4	-1.8	0.9	-0.1	0.9	0.1	0.9
Bipolar Disorder (2011)	1.4	1.3	4.6	-1.0	-0.9	-0.6	-0.5	-1.0	-2.2
Body Mass Index (BMI) (2010)	0.5	0.7	3.6	-0.1	0.0	-0.4	1.9	0.5	0.1
Coronary Artery Disease (CAD)	0.9	1.1	2.8	1.2	-0.3	-1.7	-0.2	-1.2	0.8
Crohns Disease (2012)	0.5	0.8	1.5	1.2	-1.2	-1.0	-0.5	0.0	-0.7
Mean Putamen Volume	0.2	0.2	0.5	-0.7	0.1	-0.2	0.6	-0.4	-0.1
Fasting Glucose	0.3	0.3	1.4	0.5	-0.2	-0.1	1.2	0.0	0.4
HbA1C	0.9	1.0	4.4	2.1	-1.3	-0.0	-0.0	-0.0	-0.2
HDL Cholesterol	0.9	1.6	5.8	-1.1	-1.1	-2.4	-0.8	-0.3	-0.7
LDL Cholesterol	0.4	0.6	1.2	-0.9	0.9	0.4	0.8	1.1	0.1
Lupus	0.5	0.8	2.1	-0.3	1.3	0.0	0.7	1.4	0.5
Neuroticism (2016)	0.7	1.1	3.1	0.3	0.7	1.8	-0.4	-1.6	-0.1
Primary Biliary Cirrhosis	1.6	2.2	5.2	0.0	-1.5	-1.7	-2.3	0.9	-1.4
Rheumatoid Arthritis	0.4	0.5	1.3	0.6	-0.6	-0.4	-1.2	-0.5	0.6
Schizophrenia (2014)	0.9	2.0	4.6	-0.2	-1.7	-0.3	-2.1	0.2	-2.2
Triglycerides	0.3	0.5	1.3	-1.1	-0.6	0.3	0.1	-1.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.2	-0.3	-0.7	0.7	-0.3	0.8
Ulcerative Colitis	2.4	3.5	7.3	0.6	-2.5	-2.7	-2.5	-0.6	-0.6
Blood Eosinophil Count	4.7	35.8	102.0	-9.6	0.1	-1.3	1.8	3.9	-10.1
Blood Platelet Count	0.5	6.2	15.3	-0.2	-2.6	-1.6	-3.9	-0.2	-3.6
Blood Red Count	0.3	3.3	8.0	0.6	-1.8	-1.4	-2.8	-1.5	-1.9
Blood White Count	0.5	3.9	10.8	-2.8	1.1	-1.9	-0.3	-0.0	-3.3
Heel T-Score	0.2	1.2	4.2	-1.0	0.0	-0.1	1.1	2.0	-0.9
BMI	0.2	1.2	4.9	-0.8	0.7	0.7	0.6	-2.2	-0.0
Height	0.3	6.3	10.7	3.3	-2.1	0.4	-2.8	-3.2	2.1
Waist Hip Ratio (WHR)	0.1	0.6	2.9	1.7	0.3	-0.5	0.2	-0.3	0.5
Systolic Blood Pressure	0.6	2.8	6.9	-1.4	2.1	1.7	2.6	-0.4	-0.5
Smoking Status	0.9	2.3	6.2	1.9	0.2	-1.4	-1.2	-0.5	2.5
Allergy or Eczema	0.6	1.5	4.9	0.7	-0.8	-0.6	-1.3	1.1	-2.2
Cardiovascular Disease	1.4	4.8	10.4	-0.8	3.2	2.7	3.0	-0.9	0.4
Hypothyroidism (self reported)	0.8	1.8	4.2	-0.4	-2.0	-1.5	-1.3	-0.0	-1.6
Respiratory disease	0.5	1.0	3.0	0.4	-1.0	-0.2	-1.7	-1.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.8	0.9	-0.4	-0.1	2.0	-1.9	1.0
Lung FEV1/FVC ratio	1.0	4.9	10.7	-2.9	-2.0	-2.4	0.5	0.5	-3.3
Lung FVC	0.2	1.0	4.7	0.0	-0.1	-0.1	1.1	2.2	0.3
Neuroticism	0.7	1.7	5.0	2.2	0.7	1.1	-1.0	-1.5	-0.2
Chronotype (morning person)	0.3	0.8	2.2	-1.5	-0.5	-0.5	0.1	-1.4	-0.3
Hair Pigment	0.1	1.9	6.7	-0.7	-1.3	-1.2	-1.1	-0.5	-2.6
Tanning	0.2	1.9	4.7	1.6	-0.0	2.2	0.3	-0.0	2.0
Hand grip strength (left)	0.3	0.8	3.1	-0.3	-0.9	-0.3	-0.8	1.8	-0.6
Number of treatments/medications taken	0.6	1.0	2.4	-1.0	0.6	-0.6	-0.2	-1.4	-1.5
Average weekly spirits intake	1.9	2.3	6.3	2.5	-0.2	0.2	0.1	-1.3	2.4
Sensitivity / hurt feelings	0.8	1.3	3.1	1.1	1.3	0.2	0.3	-1.7	1.4
Frequency of depressed mood in last 2 weeks	1.7	2.4	4.9	2.2	-0.6	-1.2	-1.5	-2.1	0.8
Hearing difficulty/problems: Yes	0.7	1.1	2.3	1.5	0.6	-0.5	1.5	-1.1	0.5
Relative age of first facial hair	0.7	1.5	6.9	-0.1	0.6	-0.3	1.3	0.2	2.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.8	1.3	-2.2	-0.6	-0.7	-0.5	-0.9
Ever used hormone-replacement therapy (HRT)	1.7	2.1	7.6	1.3	0.4	0.7	1.0	-1.4	2.8
Ever had hysterectomy (womb removed)	1.3	1.5	4.4	2.1	-1.3	-0.6	0.7	-1.0	1.1
Systolic blood pressure, automated reading	0.8	2.5	7.8	-0.5	2.8	2.0	1.4	-0.7	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	0.4	-0.4	-1.3	-0.3	-0.5	-1.3
Angina	0.2	0.3	1.0	0.2	0.6	-0.1	0.4	0.6	-1.0
Medication for hormone replacement therapy	1.1	1.2	4.8	0.8	-0.7	-1.1	-2.2	-0.7	0.1
Vitamin and mineral supplements	1.3	1.7	4.1	1.0	0.6	1.1	1.4	1.4	2.0
Supplements: Zinc	0.4	0.4	1.6	-0.0	0.3	1.3	-0.1	0.5	-0.7
Medication: Co-codamol	0.1	0.1	0.4	0.7	0.1	0.6	0.1	0.2	0.1
Medication: Metformin	0.9	1.2	4.2	0.3	-1.4	-0.9	0.7	-2.0	-0.3
Diabetes (father)	1.1	1.4	3.0	1.1	-1.4	-1.7	-1.3	0.8	0.2
Diabetes (mother)	0.3	0.4	1.0	-0.2	0.6	-0.8	0.1	0.7	1.0
Severe depression (siblings)	0.7	0.8	1.9	0.5	1.4	1.3	0.2	0.8	-0.1
Pack years adult smoking proportion	0.5	0.8	1.4	0.5	-0.7	-0.9	-1.2	-1.0	0.7
Impedance of leg (right)	0.3	1.6	7.1	2.7	-1.0	-0.2	-1.2	-0.2	0.1
Leg fat-free mass (left)	0.2	0.8	2.8	-1.7	0.6	0.6	0.7	-0.9	-0.2
Trunk fat percentage	0.2	0.6	2.4	-0.0	-0.1	-0.3	-0.5	-1.0	-1.5
Hand grip strength (right)	0.1	0.3	0.8	-0.0	-0.2	-0.3	-0.9	0.8	0.2
Townsend deprivation index at recruitment	0.3	0.4	1.4	-1.2	0.1	-0.5	0.1	-0.3	-0.8
Current tobacco smoking	0.2	0.4	1.2	-0.0	0.2	-0.7	-0.5	0.3	1.1
Average weekly fortified wine intake	0.2	0.3	1.2	-0.2	0.4	-1.1	0.3	0.1	-0.4
Maternal smoking around birth	0.5	0.7	2.1	0.7	-1.1	0.0	-1.4	-0.6	0.3
Fed-up feelings	1.1	1.9	5.2	1.4	0.6	0.9	1.0	-1.5	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	0.4	0.9	0.3	0.3	-0.6	0.6
Relative age voice broke	0.6	1.0	5.0	0.3	0.3	-0.8	0.1	-0.1	2.2
Taking other prescription medications	0.3	0.5	1.8	-0.6	-0.2	-0.4	-0.4	-1.4	-0.7
Age when periods started (menarche)	0.8	2.0	3.8	1.7	-2.0	-1.7	-0.7	-1.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.5	-0.9	0.1	-0.5	-0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	-1.1	-0.6	-0.5	0.4	-0.6	-1.1
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	5.7	2.1	0.7	1.4	1.2	-0.5	2.4
Qualifications: CSEs or equivalent	0.6	0.8	2.0	1.1	0.5	1.1	0.1	0.0	1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.3	-1.1	1.5	1.4	-0.2	-0.4	-0.5
High blood pressure	0.4	1.2	4.4	-0.3	2.1	0.9	1.2	-0.0	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.3	-0.3	0.0	0.1	-0.4	1.4	-1.8
Multivitamins +/- minerals	1.0	1.3	4.9	-1.3	-0.4	-0.8	0.2	0.4	-2.2
Stomach or abdominal pain in last month	4.8	6.0	21.9	0.6	1.1	4.7	3.1	1.6	0.6
Supplements: Glucosamine	0.7	0.9	2.6	-1.6	0.5	-0.2	1.0	0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	-0.0	-0.0	-0.8	-0.4	0.2	-0.4
Medication: Atenolol	0.5	0.6	2.8	0.5	-0.7	0.0	-0.2	-1.7	-0.5
Medication: Levothyroxine sodium	0.2	0.3	1.0	-0.7	-1.0	-0.0	-0.2	0.3	0.0
Sitting height	0.1	0.4	2.0	0.2	0.3	1.4	-0.4	0.1	0.1
Chronic bronchitis/emphysema (father)	1.3	1.5	3.9	1.6	2.0	0.4	1.2	-0.2	1.0
High blood pressure (mother)	1.1	1.5	3.4	-1.6	0.3	1.0	0.6	1.3	-1.8
Body mass index (BMI)	0.2	0.8	1.8	-1.3	0.1	-0.2	0.1	-1.3	-1.3
Impedance of leg (left)	0.4	1.9	7.7	2.8	-1.2	0.5	-1.2	-0.3	0.7
Leg predicted mass (left)	0.2	0.8	2.7	-1.7	0.6	0.7	0.8	-0.8	-0.1
Trunk fat mass	0.1	0.6	1.9	-0.3	0.1	0.1	-0.3	-1.4	-1.1
Waist circumference	0.1	0.4	1.8	-0.0	0.4	0.2	0.4	-1.3	-0.3
Number of incorrect matches in round	0.4	0.7	4.2	0.2	-0.2	2.1	0.0	-0.2	-0.1
Past tobacco smoking	1.6	2.9	10.3	-2.4	-0.8	-0.2	-0.0	0.7	-3.2
Alcohol usually taken with meals	1.3	2.1	3.3	-1.8	1.6	-0.5	1.4	1.5	-1.5
Nervous feelings	0.8	1.5	4.3	1.1	1.4	-0.2	-1.0	-2.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	1.0	0.7	-0.5	-0.7	-1.2	0.5
Hearing difficulty/problems with background noise	1.3	2.0	4.1	1.1	1.6	-0.6	2.0	-1.3	1.5
Hair/balding pattern: Pattern 2	0.9	1.1	3.1	1.3	-0.1	-0.4	-0.5	-1.1	1.8
Had menopause	0.5	0.6	1.7	0.5	1.3	0.4	0.7	-0.9	0.6
Had other major operations	0.8	0.9	3.4	-1.8	0.2	-0.7	0.1	0.4	-1.2
Forced vital capacity (FVC)	0.3	1.2	3.0	0.2	-0.7	1.3	1.0	0.9	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.0	-0.4	-0.9	-0.7	-0.8	-0.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.4	-1.2	0.4	-0.6	0.5	0.3	-0.5
Qualifications: None of the above	1.0	2.1	6.1	1.5	-1.2	0.3	-1.6	-2.5	-0.3
Financial difficulties in last 2 years	0.9	1.2	3.4	-0.1	-0.4	-1.5	-1.8	-0.5	-1.1
Mouth/teeth dental problems	1.1	1.6	5.3	-2.3	0.1	0.7	1.0	1.3	-1.1
Heart attack	0.2	0.2	0.8	0.2	0.2	-0.3	0.3	-0.3	-0.9
Allergy	0.2	0.4	1.0	-0.5	-0.0	-0.3	1.0	-0.2	1.0
Pain all over the body in last month	0.5	0.5	1.3	0.7	0.1	-1.0	-0.5	-0.1	1.1
Diabetes (self-reported)	0.4	0.6	2.0	0.5	-0.8	-0.6	1.4	-0.6	0.4
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	8.6	-1.4	-1.4	-1.7	-0.0	1.7	-2.9
Medication: Ramipril	0.5	0.6	1.9	0.0	0.8	1.4	1.1	-0.1	0.2
Medication: Simvastatin	0.3	0.4	1.1	-0.2	0.3	1.0	0.3	-1.0	0.2
Fluid intelligence score	1.0	2.0	2.7	0.4	1.6	1.3	1.5	1.6	1.6
Illnesses of siblings	0.6	0.9	1.9	-1.0	-0.6	-0.8	1.2	1.4	-0.2
Neuroticism score	0.9	1.9	5.4	1.7	1.4	0.5	-0.6	-2.3	0.6
Weight	0.1	0.6	2.0	-0.9	-0.1	0.3	-0.1	-1.4	-0.7
Impedance of arm (right)	0.5	2.4	4.7	2.2	-1.8	-1.8	-1.6	0.8	-0.2
Arm fat percentage (right)	0.2	0.7	2.2	-0.3	-0.0	-0.7	-0.4	-1.1	-1.5
Trunk fat-free mass	0.2	0.9	1.7	-1.3	0.8	1.2	0.8	-1.0	0.5
Hip circumference	0.2	1.0	3.1	-1.3	0.0	-0.0	-0.1	-1.8	-1.2
Time employed in main current job	2.4	2.8	6.3	-2.5	1.9	0.1	2.0	1.5	0.7
Alcohol intake versus 10 years previously	1.6	2.4	4.4	-1.6	-1.2	-2.1	-0.9	1.1	-2.0
Father’s age at death	0.4	0.6	1.8	0.1	-0.8	-0.3	-0.7	1.3	-0.8
Worrier / anxious feelings	0.7	1.2	6.8	-0.2	2.6	-0.4	0.4	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.2	1.9	0.6	0.1	0.8	-1.3	2.3
Falls in the last year	0.6	0.8	1.9	0.3	-0.2	1.4	1.3	-1.1	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	5.3	-2.3	0.5	0.4	0.2	1.2	-1.4
Number of live births	1.2	1.7	3.8	1.8	0.2	0.5	-0.8	-1.9	1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.9	-1.0	-0.8	1.2	2.0	1.3	1.0
Pulse rate	0.7	1.1	4.1	-0.2	-1.2	0.1	-1.0	-0.3	-2.0
Happiness	0.6	0.7	2.4	-0.3	-0.3	0.6	1.1	0.1	1.5
Noisy workplace	2.3	2.9	5.6	1.2	-2.4	-1.3	-1.8	-1.7	-1.5
Qualifications: A levels/AS levels or equivalent	1.0	2.3	5.0	-2.0	1.5	-1.2	-0.2	2.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	0.4	1.4	-0.1	0.6	1.8	0.0
Mouth/teeth dental problems: Dentures	1.5	2.6	6.1	1.6	-1.1	-2.2	-2.5	-1.0	-0.2
Asthma	0.5	1.0	2.8	0.2	-0.9	0.2	-1.7	-1.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	-0.7	0.3	0.1	0.3	0.5	-1.0
Medication: Cholesterol lowering	0.9	1.5	2.7	1.4	1.2	0.4	1.5	-0.7	1.6
Depression (self-reported)	1.1	1.3	3.5	-1.4	1.9	0.3	1.4	0.5	0.2
Medication: Lansoprazole	0.4	0.5	2.0	0.6	-0.0	-0.7	-0.2	-1.4	0.4
Prospective memory result	0.1	0.2	0.5	0.2	0.6	0.0	-0.2	-0.2	-0.7
Lung cancer (father)	0.4	0.4	1.2	0.4	-0.2	0.6	0.3	-0.9	1.1
Illnesses of mother	0.4	0.5	1.2	0.5	0.3	0.8	0.2	-1.0	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.6	-1.3	-1.6	0.6	1.6	0.5	-0.1
Pulse wave Arterial Stiffness index	1.9	2.2	5.4	-1.1	-1.3	-1.8	-0.8	0.9	-2.3
Impedance of arm (left)	0.4	1.7	5.4	2.3	-1.4	-1.1	-1.0	0.8	0.2
Arm fat mass (right)	0.2	0.9	3.0	-0.7	-0.0	-0.4	-0.3	-1.7	-1.2
Trunk predicted mass	0.2	0.9	1.6	-1.2	0.8	1.3	0.8	-0.8	0.5
Standing height	0.1	0.8	2.2	0.8	-0.4	1.0	-0.5	-0.6	1.5
Length of working week for main job	1.4	1.6	3.0	-1.3	1.7	1.0	0.9	1.6	-0.3
Exposure to tobacco smoke at home	0.4	0.5	2.1	0.2	0.2	-0.5	-0.2	-1.4	0.6
Breastfed as a baby	3.0	3.7	7.1	-1.5	2.7	0.9	2.5	1.3	2.0
Tense / ‘highly strung’	0.6	1.0	2.3	0.9	1.1	-1.2	-0.3	-1.5	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.9	1.0	2.0	0.1	-0.8	0.5	-0.1
Hair/balding pattern: Pattern 4	0.3	0.7	2.3	1.5	-0.9	0.3	-0.3	-0.5	-0.7
Birth weight of first child	0.1	0.2	0.6	-0.7	0.1	0.5	0.2	-0.1	0.8
Peak expiratory flow (PEF)	0.6	1.3	2.8	-1.4	-1.5	0.0	0.5	1.7	-0.8
Pulse wave reflection index	0.3	0.4	1.1	-0.7	-0.5	-0.6	0.2	0.1	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.7	-0.5	-0.4	-0.5	-1.6	-0.8
Loud music exposure frequency	0.9	1.0	3.7	-0.1	-1.9	-0.5	-1.0	0.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	-1.6	-0.6	-1.2	0.0	1.0	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.1	0.4	0.1	0.5	0.0	-2.0	0.2
Blood clot in the leg (DVT)	1.0	1.2	3.1	1.6	0.5	1.8	0.3	-0.6	1.1
Medication: Paracetamol	0.1	0.1	0.3	0.4	0.6	-0.4	-0.2	-0.0	-0.4
Headache pain in last month	0.3	0.5	1.0	-0.8	1.0	-0.7	-0.2	0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	-1.2	-1.4	0.1	-1.1	1.0	-1.0
Glaucoma (self-reported)	0.4	0.5	1.8	-0.4	-0.2	-1.3	-0.4	-0.3	-0.9
Gout (self-reported)	0.4	0.5	1.4	-1.2	0.6	0.5	-0.1	0.3	-1.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.5	-0.1	-1.6	-0.8	-1.4	0.7	-0.1
Medication: Amlodipine	0.6	0.9	2.3	-0.8	0.2	-1.5	-0.5	-0.2	-1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.4	0.2	0.0	-1.5	-1.5	-1.2	-0.2
Birth weight	1.4	3.1	9.0	-0.1	3.0	1.6	1.2	0.3	2.4
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.5	0.3	-1.7	-1.5	-2.4	-0.1	-1.8
High blood pressure (siblings)	0.9	1.3	3.9	2.0	0.4	1.3	-1.3	-0.5	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	1.9	-0.2	-1.4	0.8	1.1	0.2	0.8
Body fat percentage	0.1	0.6	2.2	0.0	0.1	-0.3	-0.3	-1.0	-1.5
Leg fat percentage (right)	0.2	0.8	2.6	-0.0	0.6	0.1	-0.0	-1.3	-1.6
Arm fat-free mass (right)	0.2	1.2	2.1	-1.5	0.9	1.4	0.6	-1.4	0.3
Exposure to tobacco smoke outside home	1.2	1.6	5.7	1.7	0.9	-0.3	0.2	-2.4	-0.1
Comparative body size at age 10	0.7	1.9	4.1	-2.0	0.9	-1.2	0.8	2.0	-0.2
Number of full brothers	0.6	0.7	3.6	0.5	-0.5	0.1	-1.9	-0.1	-0.6
Worry too long after embarrassment	0.8	1.3	3.5	1.2	1.1	0.2	-1.9	-1.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.9	-0.8	2.4	2.0	1.3	0.8	-0.2
Wheeze or whistling in the chest in last year	0.7	1.3	7.0	0.4	0.3	-0.2	-0.5	-2.6	-0.2
Number of children fathered	2.1	2.3	6.2	0.1	-0.4	1.6	2.5	1.0	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.0	-1.3	-0.9	-1.6	-1.7	-0.0	-2.0
Age at first live birth	0.9	1.6	4.7	-2.2	0.7	0.8	1.6	1.0	-0.5
Pulse wave peak to peak time	1.9	2.2	5.6	1.2	1.2	1.9	0.8	-0.9	2.4
Health satisfaction	0.4	0.5	1.8	-1.3	-1.0	-0.1	0.5	-0.2	-0.2
Shortness of breath walking on level ground	0.4	0.5	1.8	-0.7	0.2	1.4	0.8	-0.0	-0.1
Qualifications: College or University degree	0.6	2.0	5.9	-2.4	1.1	-0.6	-0.2	0.7	-2.0
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.6	1.1	0.1	0.4	0.5	1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-1.2	0.0	0.3	1.3	-1.1	-0.1
Emphysema/chronic bronchitis	0.9	1.0	3.6	0.1	1.9	1.2	0.6	0.9	0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.5	-1.0	-0.3	-0.5	0.6	0.3
Neck or shoulder pain in last month	0.6	0.9	3.8	-0.2	-0.4	0.2	0.7	-1.0	-1.9
Medication: Blood pressure	0.3	0.6	1.8	0.5	0.7	0.2	1.3	-0.7	0.5
Angina (self-reported)	0.2	0.3	0.6	0.2	0.7	-0.0	0.7	0.5	-0.7
Migraine (self-reported)	0.5	0.6	1.6	0.1	-0.5	-0.4	-1.0	0.9	-1.3
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	0.4	0.3	0.4	-0.1	-0.4
Medication: Allopurinol	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.5	0.6	0.1
Medication: Omeprazole	0.4	0.5	1.9	0.6	-0.4	-1.4	-0.6	-0.4	-0.4
Medication: Seretide 50 evohaler	0.2	0.3	0.9	0.9	0.0	-0.5	-0.6	-0.3	0.3
Mean time to correctly identify matches	1.7	3.3	10.2	2.0	0.6	0.3	0.0	-2.2	3.2
Heart disease (mother)	0.2	0.3	1.2	0.2	0.2	-0.1	1.1	0.6	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.9	-0.1	-1.7	0.6	0.1	1.1	-0.9
Whole body fat mass	0.1	0.5	2.2	-0.4	0.1	0.1	-0.0	-1.5	-0.8
Leg fat mass (right)	0.2	0.7	3.1	-0.3	0.5	0.3	0.2	-1.8	-0.8
Arm predicted mass (right)	0.3	1.5	2.4	-1.3	1.3	1.4	0.8	-1.5	0.6
Pulse rate, automated reading	0.7	2.3	4.7	0.4	-1.8	-0.1	-2.2	-1.2	-2.1
Alcohol intake frequency.	0.5	1.2	4.6	-0.9	-0.9	-0.5	-0.2	0.7	-2.2
Comparative height size at age 10	0.3	1.5	5.5	-0.1	1.2	2.3	0.3	1.4	-0.4
Number of full sisters	0.6	0.8	1.3	-0.7	-1.0	1.2	1.1	-0.2	0.7
Suffer from ‘nerves’	0.8	1.2	4.0	1.2	0.5	-0.2	-1.1	-2.0	-0.7
Overall health rating	0.5	1.1	3.6	1.9	-0.6	-0.2	-0.5	-1.5	0.2
Chest pain or discomfort	0.6	0.9	2.8	1.7	-0.2	0.1	-0.7	-1.3	0.3
Had major operations	0.5	0.6	1.3	1.1	0.4	-0.5	-1.1	-0.8	0.3
Age at last live birth	0.5	0.7	1.5	0.1	1.1	1.2	1.0	0.7	0.5
Family relationship satisfaction	0.7	0.9	2.0	-1.3	0.2	0.6	1.4	-0.6	0.9
Leg pain on walking	0.7	0.9	2.6	-1.3	-1.6	0.7	-0.0	0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.1	0.4	-1.5	-0.7	0.3	1.4	-0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.4	-0.4	-0.0	-0.6	-1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	-0.4	-0.9	-0.8	0.6	0.0	0.1
Medication: Aspirin	1.2	1.5	3.4	-1.6	1.4	0.5	1.9	-0.8	0.4
Supplements: Vitamin C	0.7	0.8	2.6	-0.6	1.6	-0.9	-0.8	-0.5	0.4
Knee pain experienced in last month	1.0	1.5	3.9	-1.2	-2.0	0.4	-0.5	-0.6	-1.7
Hypertension (Self-reported)	0.3	0.8	3.2	0.1	1.8	0.8	0.9	-0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.6	1.9	-1.3	-0.2	-1.9	-1.6	-0.9
Illnesses of father: Heart disease	0.6	0.9	1.7	1.3	0.6	-0.2	1.2	0.6	1.1
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-0.4	0.1	-1.4	-0.4	-1.4	-0.0
Smoking status: Previous	1.5	2.3	7.4	2.1	0.5	0.6	0.4	-0.9	2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.4	-0.2	-0.1	1.1	1.6	0.1	1.0
Whole body fat-free mass	0.2	0.9	2.4	-1.6	0.7	1.1	0.8	-1.0	0.2
Leg fat-free mass (right)	0.2	0.9	3.2	-1.8	0.4	1.0	0.7	-0.8	0.1
Arm fat percentage (left)	0.2	0.6	1.9	-0.5	0.2	-0.4	-0.1	-1.2	-1.4
Average weekly red wine intake	0.6	0.9	2.1	-1.1	-0.5	-0.4	-0.5	1.3	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.5	-1.1	1.1	-0.4	0.8	0.6
Mood swings	1.3	2.4	3.9	0.7	1.9	1.4	2.0	-0.8	2.0
Loneliness, isolation	0.2	0.3	1.2	0.1	1.1	0.6	0.1	-0.5	-0.0
Long-standing illness, disability or infirmity	0.4	0.7	1.4	0.7	-1.1	1.2	-0.3	-0.9	-0.2
Ever had bowel cancer screening	1.0	1.2	5.8	2.4	-0.6	-0.8	-0.2	0.1	-0.0
Diabetes diagnosed by doctor	0.8	1.2	3.1	0.7	-0.9	-0.9	1.2	-1.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.8	0.6	-0.8	-0.2	-0.6	-1.7	0.3
Friendships satisfaction	1.1	1.4	3.1	-0.5	0.5	1.3	1.5	0.7	1.8
Qualifications: nursing, teaching	1.9	3.0	5.7	-2.3	-0.3	-2.4	0.2	2.0	-1.8
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.1	1.3	1.1	0.1	0.7	0.3
Eye problems/disorders: Cataract	0.3	0.3	0.9	1.0	-0.7	-0.5	-0.4	-0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	8.0	2.8	0.6	0.6	0.1	0.1	1.1
Medication for cholesterol	0.2	0.2	0.8	0.7	0.2	-0.0	-0.3	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.2	-1.2	-1.3	0.2	-0.7	-0.5	-1.5
Back pain experienced in last month	0.3	0.5	1.4	0.3	-1.1	-0.1	1.2	-0.2	-0.1
Mineral and other dietary supplements	1.6	2.2	5.9	1.2	-2.4	-0.4	-2.4	-0.6	0.2
Breast cancer (self-reported)	0.4	0.5	1.2	-0.4	0.7	-1.1	-0.7	0.6	-0.3
Asthma (self-reported)	0.6	1.3	3.7	0.1	-1.2	-0.1	-1.9	-1.4	-0.7
Osteoporosis (self-reported)	1.4	1.7	2.7	-1.4	1.6	1.2	1.6	1.2	0.7
Osteoarthritis (self-reported)	1.3	1.6	5.9	-0.2	-2.4	-1.3	0.2	-0.5	-1.4
Medication: Aspirin	1.5	1.9	4.0	-2.0	1.8	0.6	1.7	-1.1	0.2
Medication: Gliclazide	0.5	0.5	1.6	-1.0	0.7	0.1	1.3	-0.1	0.0
Illnesses of father: None of the above (group 1)	0.7	0.9	2.3	-0.7	-1.5	-0.4	-0.4	0.7	-1.3
Smoking status: Current	0.4	0.6	1.3	-0.0	0.2	-1.1	-1.1	0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.4	-1.3	-0.5	-0.1	1.1	2.1	-1.1
Whole body water mass	0.2	0.9	2.3	-1.5	0.6	0.9	0.6	-1.1	0.2
Leg predicted mass (right)	0.2	0.8	3.0	-1.7	0.4	0.9	0.6	-0.8	0.1
Arm fat mass (left)	0.1	0.6	2.4	-0.6	-0.1	-0.1	-0.2	-1.6	-0.9
Number of self-reported non-cancer illnesses	0.7	1.1	2.7	0.9	-1.0	-0.5	-0.9	-1.6	-1.1
Average weekly champagne plus white wine intake	0.7	0.9	2.6	0.2	1.6	0.7	0.5	-0.4	1.4
Miserableness	1.1	1.8	5.2	2.3	0.9	0.1	-0.2	-1.6	1.6
Guilty feelings	0.6	0.8	4.1	0.7	2.0	0.1	-0.3	-0.6	0.2
Wears glasses or contact lenses	0.5	0.6	1.9	-0.6	-1.1	0.2	0.0	0.2	-1.4
Ever taken oral contraceptive pill	0.1	0.2	0.8	0.2	0.3	0.1	-0.1	-0.0	0.9
Hearing aid user	1.2	1.4	5.4	2.3	-0.4	-0.2	-1.1	-1.1	0.4
Mother’s age at death	0.6	0.8	2.3	-0.5	1.3	-0.1	0.4	1.5	-0.4
Financial situation satisfaction	1.3	1.6	4.0	0.7	-0.9	-0.3	-0.8	-2.0	1.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.4	1.3	0.3	-0.7	2.1	0.9	-0.0
Commuting to job workplace: Public transport	1.4	1.7	5.4	-0.4	1.0	2.3	1.4	1.2	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-1.0	-0.0	-1.1	0.1	-0.5	-0.8
Medication: Blood pressure	0.3	0.5	1.9	-0.6	0.5	0.4	0.2	0.5	-1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.3	0.0	-1.8	-0.2	-1.1	-0.0	-2.1
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.3	0.3	2.3	0.6	2.0	1.2	0.8
High cholesterol (Self-reported)	1.5	2.6	4.3	1.2	2.1	1.5	0.7	-2.1	1.6
Medication: Bendroflumethiazide	0.8	1.2	3.3	-1.1	1.8	1.2	0.8	0.7	-0.6
Medication: Paracetamol	0.3	0.4	1.4	0.3	0.5	-0.5	-0.7	-1.2	-0.2
Medication: Lisinopril	2.0	2.6	5.9	-0.1	2.3	2.1	2.4	0.1	0.4
Medication: Atorvastatin	2.7	3.3	11.6	3.4	1.6	1.2	1.4	0.6	1.5
Illnesses of father: High blood pressure	1.9	2.3	9.0	-3.0	1.7	1.1	0.5	0.1	-0.8
Alcohol drinker status: Never	0.6	0.8	2.2	-1.5	-0.2	0.4	-0.1	-1.1	-1.0
Ever smoked	1.4	2.5	8.8	1.9	1.1	0.8	0.8	0.5	3.0
Basal metabolic rate	0.1	0.8	1.9	-1.4	0.5	0.9	0.5	-1.2	0.0
Leg fat percentage (left)	0.2	0.7	2.0	0.0	0.6	0.6	-0.0	-1.4	-1.3
Arm fat-free mass (left)	0.2	0.9	2.0	-1.4	0.9	1.1	0.4	-1.1	-0.0
Number of operations (self-reported)	0.2	0.4	1.3	1.2	-0.5	-0.1	-0.4	0.3	-0.6
Average weekly beer plus cider intake	0.7	1.0	4.3	-0.6	-2.1	-0.1	-1.2	-0.4	0.1
Irritability	0.4	0.6	1.2	0.9	0.1	0.6	0.8	-1.1	0.9
Risk taking	0.4	0.6	1.5	-0.2	-1.2	0.6	0.3	1.1	-0.6
Ever had prostate specific antigen (PSA) test	1.7	1.9	4.0	-0.0	-1.1	-2.0	-0.6	1.7	-1.7
Fractured/broken bones in last 5 years	1.9	2.4	5.6	-1.3	2.2	2.4	1.3	-0.6	-0.0
Age started oral contraceptive pill	0.6	0.8	2.0	-1.4	1.4	-0.5	0.2	-0.3	-0.6
Diastolic blood pressure, automated reading	0.7	2.3	5.3	-2.3	1.9	0.2	0.2	-1.2	-1.9
Ever depressed for a whole week	1.2	1.4	4.5	-2.1	0.5	-1.5	-0.2	-0.3	-1.2
Unable to work because of sickness or disability	0.6	0.8	1.7	-0.8	0.3	-0.3	-0.9	-1.2	-1.3
Commuting to job workplace: Cycle	1.8	2.1	5.5	-0.7	1.7	2.3	1.1	0.8	1.4
Myopia	1.1	1.5	4.6	-0.7	2.1	1.0	1.3	1.2	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.5	0.8	-1.9	-0.6	-1.2	-0.4	0.8
Cholesterol lowering medication	0.3	0.5	0.9	-0.0	0.3	0.9	0.9	-0.9	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	0.7	-0.9	-1.2	-0.4	-0.4	0.2
Pain experienced in last month	0.9	1.6	4.9	1.3	1.5	0.6	0.1	-0.5	2.2
Supplements: Calcium	0.2	0.2	0.5	-0.6	0.3	0.7	0.4	-0.0	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.1	0.6	0.0	-0.4	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.8	0.2	0.1	-0.3	0.2	-0.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.1	1.6	0.2	2.0	0.3	-0.5	1.2
Heart disease (siblings)	0.9	1.1	3.5	1.4	-0.1	0.4	-1.9	-1.0	-0.5
Alcohol drinker status: Previous	1.4	1.6	4.1	2.0	-1.1	0.7	-0.7	-1.7	-0.2
Pack years of smoking	0.5	0.8	1.6	0.6	-0.3	-0.7	-1.2	-1.2	0.7
Impedance of whole body	0.3	1.7	6.0	2.4	-1.3	-0.5	-1.4	0.5	0.2
Leg fat mass (left)	0.2	0.7	3.1	-0.4	0.6	0.6	0.2	-1.8	-0.6
Arm predicted mass (left)	0.2	1.1	2.2	-1.5	0.9	1.1	0.7	-1.3	0.3