Hub : Genes

DIP2C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0666 0.0279 3.6e-03 0.010 NA 0.023 NA 0.002 0.05000 NA 6.4e-03 NA 2.0e-01
2 ROSMAP Brain Pre-frontal Cortex 0.0797 0.0346 4.7e-03 0.013 0.012 0.009 0.016 0.012 0.00710 8.3e-03 2.0e-02 3.3e-03 1.0e-02
3 YFS Blood 0.0406 0.0123 1.3e-06 0.008 0.020 0.031 0.019 0.019 0.00066 3.3e-07 1.7e-10 4.6e-07 4.2e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 3.0 1.7 0.9 0.6
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 0.1 -0.8 -0.5
Depressed Affect (Nagel 2018) 0.7 1.5 3.1 -1.8 0.9 0.7
Depression (Nagel 2018) 2.2 3.3 8.6 -2.9 -0.8 0.8
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.5 0.3 1.0 -1.2
Neuroticism (Nagel 2018) 1.0 2.3 4.7 -2.2 1.4 0.5
Schizophrenia (2018) 1.0 2.0 3.1 -1.3 -1.7 -1.1
Schizophrenia vs Biploar Disorder 1.2 1.6 2.4 -1.2 -1.6 -0.9
Worry (Nagel 2018) 0.8 1.7 4.0 -2.0 0.7 -0.8
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.2 -0.9 0.7
Alzheimer’s Disease (in father) 1.0 1.1 1.6 0.5 -1.3 -1.2
Alzheimer’s Disease (including proxy) 0.5 0.7 1.8 0.4 -1.4 -0.1
Crohns Disease (2017) 0.6 1.4 3.1 -0.7 -0.7 -1.8
Irritable Bowel Disease (IBD) 0.6 1.5 2.6 -1.1 -0.8 -1.6
Ulcerative Colitis (UC) 0.3 0.6 1.0 -1.0 -0.3 -0.9
Major Depression (MDD) 0.8 1.0 2.0 -0.4 1.4 0.9
Reaction Time 0.4 0.7 1.3 -1.1 0.6 0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.1 -0.1 0.5 -1.0
Breast Cancer 0.9 2.1 2.6 1.6 -1.1 1.6
Ovarian Cancer 2.3 3.0 7.3 1.4 -0.0 2.7
Prostate Cancer 1.2 1.7 4.1 0.9 -0.6 2.0
Age at First Birth 0.3 0.5 0.9 1.0 0.6 -0.4
Bipolar Disorder (2011) 0.3 0.3 0.5 0.7 0.6 -0.3
Body Mass Index (BMI) (2010) 0.7 1.0 2.7 0.4 -0.1 1.7
Coronary Artery Disease (CAD) 0.5 0.6 1.2 0.7 -0.3 -1.1
Crohns Disease (2012) 0.6 0.9 2.6 -0.1 -1.6 -0.2
Mean Putamen Volume 1.4 1.7 3.5 0.6 -1.0 1.9
Fasting Glucose 0.4 0.5 1.2 1.1 0.5 -0.1
HbA1C 0.1 0.1 0.2 0.4 0.3 -0.2
HDL Cholesterol 0.0 0.0 0.0 0.2 0.0 0.2
LDL Cholesterol 0.4 0.6 0.8 0.9 0.5 0.9
Lupus 0.2 0.2 0.4 0.5 0.0 0.6
Neuroticism (2016) 1.4 2.1 3.6 -1.9 1.2 -1.1
Primary Biliary Cirrhosis 0.0 0.0 0.0 -0.1 -0.1 -0.0
Rheumatoid Arthritis 0.2 0.2 0.5 -0.7 0.5 0.1
Schizophrenia (2014) 1.0 2.2 4.2 -1.6 -2.0 0.1
Triglycerides 0.5 0.8 1.9 -1.4 0.4 0.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 0.2 0.3 0.4
Ulcerative Colitis 0.3 0.4 0.7 -0.8 -0.8 -0.2
Blood Eosinophil Count 1.5 11.2 31.0 5.6 0.3 -1.6
Blood Platelet Count 0.2 2.1 3.8 -2.0 1.1 1.1
Blood Red Count 0.1 1.1 2.3 -0.3 -0.9 -1.5
Blood White Count 0.1 1.0 2.5 0.1 -0.6 1.6
Heel T-Score 0.8 6.6 16.3 4.0 1.9 0.1
BMI 0.5 2.6 5.2 -1.4 0.9 2.3
Height 0.5 10.3 30.2 -5.5 -0.3 0.8
Waist Hip Ratio (WHR) 0.3 1.5 4.2 0.0 0.6 -2.0
Systolic Blood Pressure 0.5 2.5 5.5 2.3 0.1 1.4
Smoking Status 1.5 3.6 9.8 -0.8 3.1 0.4
Allergy or Eczema 1.1 2.9 8.2 -0.7 -2.9 -0.1
Cardiovascular Disease 0.2 0.8 1.1 0.5 -1.0 -1.0
Hypothyroidism (self reported) 1.3 3.0 7.5 -1.1 0.5 2.7
Respiratory disease 2.0 4.4 12.8 -3.6 0.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.7 1.3 -0.1 1.1
Lung FEV1/FVC ratio 0.3 1.5 2.3 -0.0 -1.5 1.5
Lung FVC 0.6 3.3 5.6 2.4 -1.6 1.2
Neuroticism 1.0 2.4 4.8 -2.2 1.1 1.1
Chronotype (morning person) 1.5 3.5 7.2 1.7 -0.5 2.7
Hair Pigment 0.0 0.1 0.4 0.1 -0.3 0.6
Tanning 0.2 2.1 3.9 -1.1 -2.0 1.1
Hand grip strength (left) 0.1 0.3 0.7 -0.3 0.8 0.1
Number of treatments/medications taken 1.9 3.5 10.0 -0.6 -3.2 0.3
Average weekly spirits intake 1.0 1.2 3.4 0.0 1.8 0.5
Sensitivity / hurt feelings 0.1 0.2 0.3 -0.1 0.4 0.5
Frequency of depressed mood in last 2 weeks 2.0 2.8 6.0 -2.5 -0.7 1.4
Hearing difficulty/problems: Yes 0.2 0.2 0.6 0.7 0.2 0.3
Relative age of first facial hair 0.4 0.9 1.2 -1.1 0.6 -1.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.3 -1.8 -0.1 0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 -0.5 0.5 0.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.6 0.8 -0.1
Systolic blood pressure, automated reading 0.5 1.3 1.7 1.2 1.3 0.9
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.8 -0.4 -0.4 1.7
Angina 0.7 0.9 2.5 0.3 -0.2 -1.6
Medication for hormone replacement therapy 1.7 1.9 5.1 -2.3 -0.3 0.7
Vitamin and mineral supplements 0.4 0.6 1.6 -0.1 1.2 0.3
Supplements: Zinc 0.5 0.5 1.2 0.5 -0.4 -1.1
Medication: Co-codamol 0.9 1.0 1.6 -1.0 -1.3 0.7
Medication: Metformin 0.7 1.0 2.1 0.4 -1.5 0.9
Diabetes (father) 0.8 0.9 1.8 -1.0 -1.4 -0.2
Diabetes (mother) 0.4 0.5 0.8 0.6 0.6 0.9
Severe depression (siblings) 0.4 0.5 1.3 -0.2 -0.5 -1.1
Pack years adult smoking proportion 1.5 2.3 4.9 -2.2 1.5 0.1
Impedance of leg (right) 0.6 2.9 8.5 -0.3 -0.3 -2.9
Leg fat-free mass (left) 0.5 2.7 4.6 -1.2 1.4 2.2
Trunk fat percentage 0.2 0.9 2.1 -0.6 1.5 -0.5
Hand grip strength (right) 0.1 0.4 0.8 -0.5 0.9 0.4
Townsend deprivation index at recruitment 0.5 0.7 1.5 -1.2 -0.6 0.5
Current tobacco smoking 1.4 2.4 5.6 -1.2 2.4 0.3
Average weekly fortified wine intake 0.4 0.5 1.3 0.4 -0.3 1.1
Maternal smoking around birth 4.0 5.7 13.2 -1.9 0.3 -3.6
Fed-up feelings 1.7 3.1 5.3 -2.3 1.9 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.1 4.0 -2.0 -0.3 1.4
Relative age voice broke 0.8 1.3 2.4 -1.5 0.1 -1.2
Taking other prescription medications 0.9 1.3 1.8 -1.0 -1.0 1.3
Age when periods started (menarche) 0.4 0.9 1.8 -1.4 0.9 0.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.6 -0.8 0.3 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.0 1.4 0.1 1.0
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 5.0 0.5 -1.0 2.2
Qualifications: CSEs or equivalent 0.9 1.2 1.8 -1.3 0.4 1.3
Serious illness, injury or assault to yourself 0.2 0.2 0.7 -0.1 -0.1 0.8
High blood pressure 0.4 1.1 1.7 1.3 -1.1 -0.7
Hayfever, allergic rhinitis or eczema 0.6 1.4 4.0 -0.1 -2.0 0.3
Multivitamins +/- minerals 1.3 1.7 2.2 1.3 -1.5 -1.1
Stomach or abdominal pain in last month 1.8 2.2 6.2 0.6 0.2 2.5
Supplements: Glucosamine 0.0 0.1 0.1 0.3 0.1 -0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.4 -0.6 0.1 0.3
Medication: Atenolol 0.9 1.1 1.9 0.6 -1.4 1.1
Medication: Levothyroxine sodium 0.6 1.1 2.2 -1.0 0.0 1.5
Sitting height 0.5 3.3 5.2 -2.3 1.7 -1.3
Chronic bronchitis/emphysema (father) 1.3 1.5 2.3 1.5 -0.4 -1.5
High blood pressure (mother) 0.8 1.1 2.9 0.3 0.5 -1.7
Body mass index (BMI) 0.4 1.8 3.3 -0.8 1.1 1.8
Impedance of leg (left) 0.6 2.7 7.7 -0.7 0.0 -2.8
Leg predicted mass (left) 0.5 2.7 4.8 -1.2 1.4 2.2
Trunk fat mass 0.3 1.5 2.9 -1.2 1.7 0.1
Waist circumference 0.3 1.2 1.9 -1.2 1.4 0.6
Number of incorrect matches in round 0.7 1.1 2.8 0.4 -0.7 1.7
Past tobacco smoking 1.0 1.8 5.0 -0.5 -2.2 -0.3
Alcohol usually taken with meals 2.2 3.5 5.6 2.2 -2.4 -0.1
Nervous feelings 1.9 3.5 9.7 -3.1 1.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 6.8 -2.6 0.1 -1.0
Hearing difficulty/problems with background noise 0.5 0.8 1.2 1.1 1.1 0.4
Hair/balding pattern: Pattern 2 1.1 1.4 3.5 -0.9 -0.2 1.9
Had menopause 0.9 1.2 2.6 0.7 -0.6 -1.6
Had other major operations 2.2 2.7 5.7 1.3 -2.4 0.8
Forced vital capacity (FVC) 0.2 0.7 1.2 -0.8 -0.5 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.7 0.2 -0.1 1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 -0.4 0.6 0.8
Qualifications: None of the above 0.8 1.8 3.5 -0.9 1.9 -1.1
Financial difficulties in last 2 years 1.3 1.7 3.7 -1.2 -0.1 -1.9
Mouth/teeth dental problems 0.3 0.5 0.8 0.7 -0.9 0.4
Heart attack 1.6 2.1 5.9 2.4 0.4 -0.4
Allergy 0.8 1.8 2.8 1.7 1.2 -1.1
Pain all over the body in last month 0.4 0.4 0.8 -0.9 -0.6 -0.4
Diabetes (self-reported) 1.2 1.9 3.2 1.5 -0.5 1.8
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 5.3 0.7 -2.3 1.6
Medication: Ramipril 0.3 0.4 0.5 0.7 0.4 -0.7
Medication: Simvastatin 0.4 0.6 1.1 -1.0 0.3 -0.8
Fluid intelligence score 0.7 1.4 2.4 1.6 1.0 -0.9
Illnesses of siblings 1.0 1.4 3.8 0.7 0.0 1.9
Neuroticism score 0.6 1.3 2.2 -1.5 1.1 0.8
Weight 0.6 3.0 4.1 -2.0 1.7 1.4
Impedance of arm (right) 0.7 3.5 8.9 1.0 -0.7 -3.0
Arm fat percentage (right) 0.1 0.5 0.7 -0.4 0.8 0.7
Trunk fat-free mass 0.6 3.3 4.5 -2.0 1.1 2.1
Hip circumference 0.3 1.5 2.4 -1.5 0.8 1.2
Time employed in main current job 0.6 0.7 1.8 1.3 -0.3 -0.4
Alcohol intake versus 10 years previously 1.0 1.5 4.0 2.0 0.5 -0.5
Father’s age at death 0.1 0.1 0.4 0.0 -0.3 -0.6
Worrier / anxious feelings 0.1 0.2 0.2 0.3 0.3 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.2 -1.3 0.8 -1.5
Falls in the last year 2.7 3.7 7.4 -0.9 -1.6 2.7
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 0.2 -0.6 0.1
Number of live births 0.4 0.5 1.5 -1.2 0.3 -0.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.9 -0.1 -1.0 1.4
Pulse rate 0.8 1.4 3.8 -0.4 2.0 -0.4
Happiness 1.3 1.6 3.2 -1.1 1.8 0.5
Noisy workplace 0.7 0.9 2.7 -1.6 0.2 0.0
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.0 1.0 0.5 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 -0.1 0.1 0.6
Mouth/teeth dental problems: Dentures 0.5 0.9 2.2 -1.5 0.1 -0.6
Asthma 1.3 2.5 7.5 -2.7 -0.2 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 0.9 0.9 -0.4 0.8
Medication: Cholesterol lowering 0.3 0.4 0.8 0.5 -0.9 0.3
Depression (self-reported) 0.1 0.1 0.4 0.6 -0.2 -0.0
Medication: Lansoprazole 1.0 1.1 2.6 0.9 -1.6 -0.1
Prospective memory result 0.7 0.9 1.9 1.4 0.4 -0.8
Lung cancer (father) 0.5 0.5 0.8 -0.2 0.9 0.9
Illnesses of mother 0.8 1.0 2.7 -0.5 -0.2 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.1 0.1 -1.7 1.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 0.3 0.2 -0.6
Impedance of arm (left) 0.7 3.3 8.9 0.7 -0.6 -3.0
Arm fat mass (right) 0.4 1.4 1.8 -1.2 1.0 1.4
Trunk predicted mass 0.6 3.3 4.4 -2.0 1.2 2.1
Standing height 0.3 3.0 6.5 -2.5 1.4 -0.7
Length of working week for main job 0.7 0.8 2.2 -0.2 -0.4 -1.5
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.2 -0.3 0.4
Breastfed as a baby 0.3 0.4 0.6 0.3 -0.8 0.7
Tense / ‘highly strung’ 0.7 1.2 3.4 0.0 1.9 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.0 -0.6 0.3 1.4
Hair/balding pattern: Pattern 4 0.7 1.7 3.4 -0.8 1.0 -1.9
Birth weight of first child 0.3 0.6 0.9 -1.0 -0.2 -0.8
Peak expiratory flow (PEF) 0.1 0.3 0.8 -0.0 -0.9 0.1
Pulse wave reflection index 0.6 0.8 1.3 0.8 -1.2 0.6
Ever highly irritable/argumentative for 2 days 2.0 2.4 4.1 -1.6 0.8 2.0
Loud music exposure frequency 1.6 1.7 2.2 -1.3 -1.0 1.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.0 -0.7 0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.7 0.1 1.3 -0.0
Blood clot in the leg (DVT) 0.4 0.5 0.8 -0.8 -0.4 -0.9
Medication: Paracetamol 0.1 0.2 0.3 0.5 -0.4 -0.1
Headache pain in last month 0.4 0.6 0.8 0.6 0.9 -0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.6 -0.0 1.3 0.4
Glaucoma (self-reported) 0.3 0.3 0.5 -0.7 0.4 -0.7
Gout (self-reported) 0.5 0.6 1.0 0.6 -1.0 0.7
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.7 -1.6 0.7 1.6
Medication: Amlodipine 1.4 1.9 4.5 0.5 -1.0 -2.1
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.9 -1.0 1.7 -0.0
Birth weight 0.0 0.0 0.0 -0.1 -0.2 0.2
Chronic bronchitis/emphysema (mother) 1.5 1.7 2.3 -1.1 1.2 -1.5
High blood pressure (siblings) 1.4 2.0 3.1 -1.7 0.1 -1.8
Forced vital capacity (FVC), Best measure 0.5 1.8 2.7 -0.5 -1.6 1.6
Body fat percentage 0.2 0.8 2.1 -0.6 1.4 -0.1
Leg fat percentage (right) 0.1 0.5 1.3 -0.4 1.2 0.3
Arm fat-free mass (right) 0.9 4.6 5.8 -2.4 1.8 2.1
Exposure to tobacco smoke outside home 0.2 0.2 0.4 -0.4 -0.7 -0.2
Comparative body size at age 10 0.2 0.5 0.9 0.6 -0.3 1.0
Number of full brothers 0.6 0.7 2.1 -1.5 -0.3 0.2
Worry too long after embarrassment 2.1 3.5 5.6 -1.4 2.4 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.1 0.5 1.0
Wheeze or whistling in the chest in last year 0.3 0.6 1.6 -0.3 -0.1 -1.3
Number of children fathered 1.7 2.0 3.2 1.5 1.8 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 3.2 0.8 -1.8 -1.0
Age at first live birth 0.4 0.7 1.8 1.3 -0.1 0.5
Pulse wave peak to peak time 0.2 0.3 0.4 -0.5 -0.3 0.6
Health satisfaction 0.4 0.6 1.1 -0.7 1.1 0.2
Shortness of breath walking on level ground 1.1 1.3 3.0 0.5 1.7 0.7
Qualifications: College or University degree 0.1 0.2 0.5 0.7 -0.3 0.3
Eye problems/disorders: None of the above 1.4 1.6 3.3 0.2 -1.8 -1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.3 0.6 -0.5 0.5
Emphysema/chronic bronchitis 0.9 1.0 2.4 0.7 1.5 -0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 -0.7 0.5 -0.3
Neck or shoulder pain in last month 1.9 2.7 5.4 -0.1 -1.6 2.3
Medication: Blood pressure 0.8 1.5 3.2 0.2 -1.0 -1.8
Angina (self-reported) 0.7 0.9 2.2 0.5 -0.4 -1.5
Migraine (self-reported) 0.2 0.3 0.7 -0.2 -0.9 -0.4
Medication: Ibuprofen 0.3 0.3 0.7 0.5 0.1 0.8
Medication: Allopurinol 0.4 0.6 1.7 -0.3 -0.0 1.3
Medication: Omeprazole 0.5 0.6 1.7 -0.1 -1.3 0.0
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.3 -0.0 -0.5
Mean time to correctly identify matches 0.1 0.2 0.4 -0.2 -0.6 -0.4
Heart disease (mother) 1.8 2.2 3.7 1.7 -0.5 -1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.8 8.1 0.3 0.4 -2.8
Whole body fat mass 0.4 1.7 3.0 -1.4 1.7 0.6
Leg fat mass (right) 0.4 1.7 2.6 -1.2 1.6 1.1
Arm predicted mass (right) 0.7 3.4 4.3 -2.1 1.6 1.8
Pulse rate, automated reading 0.6 1.8 4.6 -2.2 0.2 -0.9
Alcohol intake frequency. 0.1 0.2 0.5 0.7 0.3 0.0
Comparative height size at age 10 0.1 0.6 1.5 -1.2 0.4 -0.2
Number of full sisters 0.3 0.3 1.0 0.1 0.3 1.0
Suffer from ‘nerves’ 1.2 1.8 4.8 -2.2 -0.1 -0.8
Overall health rating 0.1 0.3 0.8 -0.9 -0.4 -0.0
Chest pain or discomfort 0.1 0.2 0.4 0.1 0.7 -0.4
Had major operations 1.2 1.4 3.8 -1.9 0.5 0.4
Age at last live birth 0.4 0.6 1.3 1.1 -0.2 -0.6
Family relationship satisfaction 1.7 2.1 2.9 -1.2 1.4 1.7
Leg pain on walking 0.9 1.1 1.9 -1.2 0.2 1.4
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.4 1.1 -1.5 -0.5
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.4 -0.4 -0.2 1.2
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.7 1.3 0.1 1.0
Medication: Aspirin 0.6 0.8 2.0 1.4 0.5 0.3
Supplements: Vitamin C 0.8 1.0 1.3 1.0 0.8 -1.1
Knee pain experienced in last month 0.8 1.2 2.6 -0.7 -1.6 0.7
Hypertension (Self-reported) 0.2 0.6 0.9 0.7 -0.7 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.3 3.9 -1.8 -2.0 -0.3
Illnesses of father: Heart disease 1.1 1.5 2.5 1.6 0.4 -1.3
Illnesses of siblings: Diabetes 0.0 0.1 0.1 0.3 -0.0 0.3
Smoking status: Previous 0.7 1.1 1.3 0.8 1.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 -0.6 0.6 0.8
Whole body fat-free mass 0.5 3.1 4.6 -1.7 1.3 2.1
Leg fat-free mass (right) 0.6 3.0 4.8 -1.3 1.6 2.2
Arm fat percentage (left) 0.1 0.5 0.8 -0.6 0.9 0.7
Average weekly red wine intake 1.2 1.8 3.6 -1.3 -1.9 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.6 0.5 0.3 -0.8
Mood swings 0.4 0.7 1.3 -0.3 0.7 1.2
Loneliness, isolation 0.7 1.0 2.0 -1.4 -1.0 -0.3
Long-standing illness, disability or infirmity 1.3 1.9 2.3 -1.2 -1.5 1.4
Ever had bowel cancer screening 0.5 0.5 0.6 0.7 0.7 -0.8
Diabetes diagnosed by doctor 1.0 1.6 2.7 1.6 -0.5 1.4
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.5 3.8 -2.0 -0.9 1.7
Friendships satisfaction 0.7 0.9 2.4 -1.6 -0.3 0.3
Qualifications: nursing, teaching 0.6 1.0 1.7 1.3 -0.5 1.0
Commuting to job workplace: Walk 0.6 0.6 0.9 -0.9 1.0 -0.4
Eye problems/disorders: Cataract 0.2 0.2 0.7 -0.3 -0.1 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.1 -0.4 0.1
Medication for cholesterol 0.4 0.6 1.1 -0.2 0.8 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.2 3.6 -1.9 0.1 0.2
Back pain experienced in last month 1.2 1.7 4.1 0.6 -0.9 2.0
Mineral and other dietary supplements 2.8 3.8 7.2 -2.7 1.8 1.0
Breast cancer (self-reported) 0.7 0.9 1.4 0.1 1.1 -1.2
Asthma (self-reported) 1.5 3.1 9.1 -3.0 0.2 0.2
Osteoporosis (self-reported) 0.6 0.8 0.9 1.0 0.9 -0.8
Osteoarthritis (self-reported) 0.7 0.9 2.2 0.6 -1.5 -0.4
Medication: Aspirin 0.5 0.7 1.5 1.2 0.5 0.6
Medication: Gliclazide 0.5 0.6 0.6 0.8 -0.8 0.7
Illnesses of father: None of the above (group 1) 1.0 1.2 2.9 0.1 0.9 1.7
Smoking status: Current 1.9 2.9 6.9 -1.4 2.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 2.9 0.6 -1.7 1.0
Whole body water mass 0.6 3.5 5.0 -1.9 1.4 2.2
Leg predicted mass (right) 0.6 3.1 5.1 -1.4 1.6 2.3
Arm fat mass (left) 0.4 1.7 2.0 -1.4 1.3 1.2
Number of self-reported non-cancer illnesses 1.0 1.7 2.8 -1.4 -1.7 0.7
Average weekly champagne plus white wine intake 0.7 1.0 1.7 0.9 1.3 -0.6
Miserableness 1.1 1.9 2.9 -1.7 1.2 1.2
Guilty feelings 0.1 0.1 0.2 -0.3 0.5 0.2
Wears glasses or contact lenses 1.9 2.2 5.7 0.0 -1.0 2.4
Ever taken oral contraceptive pill 0.9 1.0 1.2 -1.1 1.1 0.8
Hearing aid user 0.0 0.1 0.1 -0.1 0.4 0.2
Mother’s age at death 0.7 0.9 1.3 1.2 0.9 -0.7
Financial situation satisfaction 1.5 1.9 4.7 -2.2 0.9 0.3
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.3 1.5 -0.9 0.2
Commuting to job workplace: Public transport 1.3 1.6 4.5 0.5 0.1 -2.1
Eye problems/disorders: Glaucoma 0.9 1.1 2.9 -0.2 1.7 0.5
Medication: Blood pressure 0.3 0.5 1.4 1.2 -0.2 -0.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.2 -0.2 -1.5 -0.7
Supplements: Fish oil (including cod liver oil) 3.2 4.2 8.1 2.8 -1.8 -1.1
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.6 -0.5 -0.4
Medication: Bendroflumethiazide 0.4 0.6 1.0 0.8 -0.4 -1.0
Medication: Paracetamol 0.2 0.3 0.7 0.0 -0.9 0.4
Medication: Lisinopril 0.6 0.8 1.8 1.3 -0.8 0.3
Medication: Atorvastatin 0.8 1.0 1.5 1.2 -0.8 1.0
Illnesses of father: High blood pressure 0.3 0.4 1.1 -0.2 -1.1 -0.2
Alcohol drinker status: Never 0.1 0.1 0.3 0.0 -0.5 -0.2
Ever smoked 1.1 1.9 4.8 1.0 2.2 -0.1
Basal metabolic rate 0.6 3.5 4.6 -1.9 1.5 2.1
Leg fat percentage (left) 0.2 0.7 1.6 -0.6 1.3 0.5
Arm fat-free mass (left) 0.7 3.5 3.8 -1.9 1.8 1.9
Number of operations (self-reported) 0.5 0.8 1.2 -1.1 -1.0 0.4
Average weekly beer plus cider intake 0.8 1.1 3.2 -1.8 0.0 -0.4
Irritability 0.6 0.9 2.0 -0.3 1.4 0.9
Risk taking 0.5 0.7 2.0 0.1 0.1 -1.4
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.8 1.2 0.7 1.7
Fractured/broken bones in last 5 years 0.3 0.5 1.0 0.2 0.5 1.0
Age started oral contraceptive pill 1.8 2.3 5.6 -0.4 1.0 -2.4
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.9 -0.2 0.6
Ever depressed for a whole week 0.5 0.7 1.3 0.4 1.1 0.8
Unable to work because of sickness or disability 1.8 2.3 6.7 -2.6 -0.5 0.0
Commuting to job workplace: Cycle 0.2 0.2 0.4 0.4 0.6 0.1
Myopia 2.2 3.2 7.6 1.4 -2.8 -0.5
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.3 -1.5 1.0 1.1
Cholesterol lowering medication 0.1 0.2 0.4 0.6 0.5 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 2.6 -0.5 -1.6 0.2
Pain experienced in last month 1.1 1.9 3.5 0.1 1.5 -1.9
Supplements: Calcium 1.0 1.1 2.4 -0.9 -1.5 0.1
Basal cell carcinoma (self-reported) 0.7 0.9 1.4 -0.4 1.0 1.2
Heart attack/myocardial infarction (self-reported) 1.5 2.0 5.2 2.3 0.4 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.2 -1.1 -0.2 -0.4
Heart disease (siblings) 0.3 0.4 0.9 -1.0 -0.1 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.4 0.2 -0.5 1.2
Pack years of smoking 1.8 2.6 5.9 -2.4 1.4 0.2
Impedance of whole body 0.8 3.9 11.6 0.3 -0.3 -3.4
Leg fat mass (left) 0.5 2.1 3.1 -1.3 1.8 1.2
Arm predicted mass (left) 0.8 3.9 4.6 -2.0 1.8 2.1