Hub : Genes

DIP2C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0666	0.0279	3.6e-03	0.010	NA	0.023	NA	0.002	0.05000	NA	6.4e-03	NA	2.0e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.0797	0.0346	4.7e-03	0.013	0.012	0.009	0.016	0.012	0.00710	8.3e-03	2.0e-02	3.3e-03	1.0e-02
3	YFS	Blood	0.0406	0.0123	1.3e-06	0.008	0.020	0.031	0.019	0.019	0.00066	3.3e-07	1.7e-10	4.6e-07	4.2e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	3.0	1.7	0.9	0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.1	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.7	1.5	3.1	-1.8	0.9	0.7
Depression (Nagel 2018)	2.2	3.3	8.6	-2.9	-0.8	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	0.3	1.0	-1.2
Neuroticism (Nagel 2018)	1.0	2.3	4.7	-2.2	1.4	0.5
Schizophrenia (2018)	1.0	2.0	3.1	-1.3	-1.7	-1.1
Schizophrenia vs Biploar Disorder	1.2	1.6	2.4	-1.2	-1.6	-0.9
Worry (Nagel 2018)	0.8	1.7	4.0	-2.0	0.7	-0.8
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.2	-0.9	0.7
Alzheimer’s Disease (in father)	1.0	1.1	1.6	0.5	-1.3	-1.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	0.4	-1.4	-0.1
Crohns Disease (2017)	0.6	1.4	3.1	-0.7	-0.7	-1.8
Irritable Bowel Disease (IBD)	0.6	1.5	2.6	-1.1	-0.8	-1.6
Ulcerative Colitis (UC)	0.3	0.6	1.0	-1.0	-0.3	-0.9
Major Depression (MDD)	0.8	1.0	2.0	-0.4	1.4	0.9
Reaction Time	0.4	0.7	1.3	-1.1	0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-0.1	0.5	-1.0
Breast Cancer	0.9	2.1	2.6	1.6	-1.1	1.6
Ovarian Cancer	2.3	3.0	7.3	1.4	-0.0	2.7
Prostate Cancer	1.2	1.7	4.1	0.9	-0.6	2.0
Age at First Birth	0.3	0.5	0.9	1.0	0.6	-0.4
Bipolar Disorder (2011)	0.3	0.3	0.5	0.7	0.6	-0.3
Body Mass Index (BMI) (2010)	0.7	1.0	2.7	0.4	-0.1	1.7
Coronary Artery Disease (CAD)	0.5	0.6	1.2	0.7	-0.3	-1.1
Crohns Disease (2012)	0.6	0.9	2.6	-0.1	-1.6	-0.2
Mean Putamen Volume	1.4	1.7	3.5	0.6	-1.0	1.9
Fasting Glucose	0.4	0.5	1.2	1.1	0.5	-0.1
HbA1C	0.1	0.1	0.2	0.4	0.3	-0.2
HDL Cholesterol	0.0	0.0	0.0	0.2	0.0	0.2
LDL Cholesterol	0.4	0.6	0.8	0.9	0.5	0.9
Lupus	0.2	0.2	0.4	0.5	0.0	0.6
Neuroticism (2016)	1.4	2.1	3.6	-1.9	1.2	-1.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	-0.1	-0.0
Rheumatoid Arthritis	0.2	0.2	0.5	-0.7	0.5	0.1
Schizophrenia (2014)	1.0	2.2	4.2	-1.6	-2.0	0.1
Triglycerides	0.5	0.8	1.9	-1.4	0.4	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.2	0.3	0.4
Ulcerative Colitis	0.3	0.4	0.7	-0.8	-0.8	-0.2
Blood Eosinophil Count	1.5	11.2	31.0	5.6	0.3	-1.6
Blood Platelet Count	0.2	2.1	3.8	-2.0	1.1	1.1
Blood Red Count	0.1	1.1	2.3	-0.3	-0.9	-1.5
Blood White Count	0.1	1.0	2.5	0.1	-0.6	1.6
Heel T-Score	0.8	6.6	16.3	4.0	1.9	0.1
BMI	0.5	2.6	5.2	-1.4	0.9	2.3
Height	0.5	10.3	30.2	-5.5	-0.3	0.8
Waist Hip Ratio (WHR)	0.3	1.5	4.2	0.0	0.6	-2.0
Systolic Blood Pressure	0.5	2.5	5.5	2.3	0.1	1.4
Smoking Status	1.5	3.6	9.8	-0.8	3.1	0.4
Allergy or Eczema	1.1	2.9	8.2	-0.7	-2.9	-0.1
Cardiovascular Disease	0.2	0.8	1.1	0.5	-1.0	-1.0
Hypothyroidism (self reported)	1.3	3.0	7.5	-1.1	0.5	2.7
Respiratory disease	2.0	4.4	12.8	-3.6	0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	1.3	-0.1	1.1
Lung FEV1/FVC ratio	0.3	1.5	2.3	-0.0	-1.5	1.5
Lung FVC	0.6	3.3	5.6	2.4	-1.6	1.2
Neuroticism	1.0	2.4	4.8	-2.2	1.1	1.1
Chronotype (morning person)	1.5	3.5	7.2	1.7	-0.5	2.7
Hair Pigment	0.0	0.1	0.4	0.1	-0.3	0.6
Tanning	0.2	2.1	3.9	-1.1	-2.0	1.1
Hand grip strength (left)	0.1	0.3	0.7	-0.3	0.8	0.1
Number of treatments/medications taken	1.9	3.5	10.0	-0.6	-3.2	0.3
Average weekly spirits intake	1.0	1.2	3.4	0.0	1.8	0.5
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.1	0.4	0.5
Frequency of depressed mood in last 2 weeks	2.0	2.8	6.0	-2.5	-0.7	1.4
Hearing difficulty/problems: Yes	0.2	0.2	0.6	0.7	0.2	0.3
Relative age of first facial hair	0.4	0.9	1.2	-1.1	0.6	-1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.3	-1.8	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.5	0.5	0.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.6	0.8	-0.1
Systolic blood pressure, automated reading	0.5	1.3	1.7	1.2	1.3	0.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.8	-0.4	-0.4	1.7
Angina	0.7	0.9	2.5	0.3	-0.2	-1.6
Medication for hormone replacement therapy	1.7	1.9	5.1	-2.3	-0.3	0.7
Vitamin and mineral supplements	0.4	0.6	1.6	-0.1	1.2	0.3
Supplements: Zinc	0.5	0.5	1.2	0.5	-0.4	-1.1
Medication: Co-codamol	0.9	1.0	1.6	-1.0	-1.3	0.7
Medication: Metformin	0.7	1.0	2.1	0.4	-1.5	0.9
Diabetes (father)	0.8	0.9	1.8	-1.0	-1.4	-0.2
Diabetes (mother)	0.4	0.5	0.8	0.6	0.6	0.9
Severe depression (siblings)	0.4	0.5	1.3	-0.2	-0.5	-1.1
Pack years adult smoking proportion	1.5	2.3	4.9	-2.2	1.5	0.1
Impedance of leg (right)	0.6	2.9	8.5	-0.3	-0.3	-2.9
Leg fat-free mass (left)	0.5	2.7	4.6	-1.2	1.4	2.2
Trunk fat percentage	0.2	0.9	2.1	-0.6	1.5	-0.5
Hand grip strength (right)	0.1	0.4	0.8	-0.5	0.9	0.4
Townsend deprivation index at recruitment	0.5	0.7	1.5	-1.2	-0.6	0.5
Current tobacco smoking	1.4	2.4	5.6	-1.2	2.4	0.3
Average weekly fortified wine intake	0.4	0.5	1.3	0.4	-0.3	1.1
Maternal smoking around birth	4.0	5.7	13.2	-1.9	0.3	-3.6
Fed-up feelings	1.7	3.1	5.3	-2.3	1.9	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	4.0	-2.0	-0.3	1.4
Relative age voice broke	0.8	1.3	2.4	-1.5	0.1	-1.2
Taking other prescription medications	0.9	1.3	1.8	-1.0	-1.0	1.3
Age when periods started (menarche)	0.4	0.9	1.8	-1.4	0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	-0.8	0.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	1.4	0.1	1.0
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.0	0.5	-1.0	2.2
Qualifications: CSEs or equivalent	0.9	1.2	1.8	-1.3	0.4	1.3
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.1	-0.1	0.8
High blood pressure	0.4	1.1	1.7	1.3	-1.1	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.0	-0.1	-2.0	0.3
Multivitamins +/- minerals	1.3	1.7	2.2	1.3	-1.5	-1.1
Stomach or abdominal pain in last month	1.8	2.2	6.2	0.6	0.2	2.5
Supplements: Glucosamine	0.0	0.1	0.1	0.3	0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.6	0.1	0.3
Medication: Atenolol	0.9	1.1	1.9	0.6	-1.4	1.1
Medication: Levothyroxine sodium	0.6	1.1	2.2	-1.0	0.0	1.5
Sitting height	0.5	3.3	5.2	-2.3	1.7	-1.3
Chronic bronchitis/emphysema (father)	1.3	1.5	2.3	1.5	-0.4	-1.5
High blood pressure (mother)	0.8	1.1	2.9	0.3	0.5	-1.7
Body mass index (BMI)	0.4	1.8	3.3	-0.8	1.1	1.8
Impedance of leg (left)	0.6	2.7	7.7	-0.7	0.0	-2.8
Leg predicted mass (left)	0.5	2.7	4.8	-1.2	1.4	2.2
Trunk fat mass	0.3	1.5	2.9	-1.2	1.7	0.1
Waist circumference	0.3	1.2	1.9	-1.2	1.4	0.6
Number of incorrect matches in round	0.7	1.1	2.8	0.4	-0.7	1.7
Past tobacco smoking	1.0	1.8	5.0	-0.5	-2.2	-0.3
Alcohol usually taken with meals	2.2	3.5	5.6	2.2	-2.4	-0.1
Nervous feelings	1.9	3.5	9.7	-3.1	1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.8	-2.6	0.1	-1.0
Hearing difficulty/problems with background noise	0.5	0.8	1.2	1.1	1.1	0.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	-0.9	-0.2	1.9
Had menopause	0.9	1.2	2.6	0.7	-0.6	-1.6
Had other major operations	2.2	2.7	5.7	1.3	-2.4	0.8
Forced vital capacity (FVC)	0.2	0.7	1.2	-0.8	-0.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	0.2	-0.1	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.4	0.6	0.8
Qualifications: None of the above	0.8	1.8	3.5	-0.9	1.9	-1.1
Financial difficulties in last 2 years	1.3	1.7	3.7	-1.2	-0.1	-1.9
Mouth/teeth dental problems	0.3	0.5	0.8	0.7	-0.9	0.4
Heart attack	1.6	2.1	5.9	2.4	0.4	-0.4
Allergy	0.8	1.8	2.8	1.7	1.2	-1.1
Pain all over the body in last month	0.4	0.4	0.8	-0.9	-0.6	-0.4
Diabetes (self-reported)	1.2	1.9	3.2	1.5	-0.5	1.8
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.3	0.7	-2.3	1.6
Medication: Ramipril	0.3	0.4	0.5	0.7	0.4	-0.7
Medication: Simvastatin	0.4	0.6	1.1	-1.0	0.3	-0.8
Fluid intelligence score	0.7	1.4	2.4	1.6	1.0	-0.9
Illnesses of siblings	1.0	1.4	3.8	0.7	0.0	1.9
Neuroticism score	0.6	1.3	2.2	-1.5	1.1	0.8
Weight	0.6	3.0	4.1	-2.0	1.7	1.4
Impedance of arm (right)	0.7	3.5	8.9	1.0	-0.7	-3.0
Arm fat percentage (right)	0.1	0.5	0.7	-0.4	0.8	0.7
Trunk fat-free mass	0.6	3.3	4.5	-2.0	1.1	2.1
Hip circumference	0.3	1.5	2.4	-1.5	0.8	1.2
Time employed in main current job	0.6	0.7	1.8	1.3	-0.3	-0.4
Alcohol intake versus 10 years previously	1.0	1.5	4.0	2.0	0.5	-0.5
Father’s age at death	0.1	0.1	0.4	0.0	-0.3	-0.6
Worrier / anxious feelings	0.1	0.2	0.2	0.3	0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.2	-1.3	0.8	-1.5
Falls in the last year	2.7	3.7	7.4	-0.9	-1.6	2.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.2	-0.6	0.1
Number of live births	0.4	0.5	1.5	-1.2	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.9	-0.1	-1.0	1.4
Pulse rate	0.8	1.4	3.8	-0.4	2.0	-0.4
Happiness	1.3	1.6	3.2	-1.1	1.8	0.5
Noisy workplace	0.7	0.9	2.7	-1.6	0.2	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	1.0	0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.1	0.1	0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	2.2	-1.5	0.1	-0.6
Asthma	1.3	2.5	7.5	-2.7	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	0.9	0.9	-0.4	0.8
Medication: Cholesterol lowering	0.3	0.4	0.8	0.5	-0.9	0.3
Depression (self-reported)	0.1	0.1	0.4	0.6	-0.2	-0.0
Medication: Lansoprazole	1.0	1.1	2.6	0.9	-1.6	-0.1
Prospective memory result	0.7	0.9	1.9	1.4	0.4	-0.8
Lung cancer (father)	0.5	0.5	0.8	-0.2	0.9	0.9
Illnesses of mother	0.8	1.0	2.7	-0.5	-0.2	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.1	0.1	-1.7	1.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.3	0.2	-0.6
Impedance of arm (left)	0.7	3.3	8.9	0.7	-0.6	-3.0
Arm fat mass (right)	0.4	1.4	1.8	-1.2	1.0	1.4
Trunk predicted mass	0.6	3.3	4.4	-2.0	1.2	2.1
Standing height	0.3	3.0	6.5	-2.5	1.4	-0.7
Length of working week for main job	0.7	0.8	2.2	-0.2	-0.4	-1.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	-0.3	0.4
Breastfed as a baby	0.3	0.4	0.6	0.3	-0.8	0.7
Tense / ‘highly strung’	0.7	1.2	3.4	0.0	1.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.0	-0.6	0.3	1.4
Hair/balding pattern: Pattern 4	0.7	1.7	3.4	-0.8	1.0	-1.9
Birth weight of first child	0.3	0.6	0.9	-1.0	-0.2	-0.8
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.0	-0.9	0.1
Pulse wave reflection index	0.6	0.8	1.3	0.8	-1.2	0.6
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.1	-1.6	0.8	2.0
Loud music exposure frequency	1.6	1.7	2.2	-1.3	-1.0	1.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.0	-0.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.7	0.1	1.3	-0.0
Blood clot in the leg (DVT)	0.4	0.5	0.8	-0.8	-0.4	-0.9
Medication: Paracetamol	0.1	0.2	0.3	0.5	-0.4	-0.1
Headache pain in last month	0.4	0.6	0.8	0.6	0.9	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.0	1.3	0.4
Glaucoma (self-reported)	0.3	0.3	0.5	-0.7	0.4	-0.7
Gout (self-reported)	0.5	0.6	1.0	0.6	-1.0	0.7
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.7	-1.6	0.7	1.6
Medication: Amlodipine	1.4	1.9	4.5	0.5	-1.0	-2.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	-1.0	1.7	-0.0
Birth weight	0.0	0.0	0.0	-0.1	-0.2	0.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.3	-1.1	1.2	-1.5
High blood pressure (siblings)	1.4	2.0	3.1	-1.7	0.1	-1.8
Forced vital capacity (FVC), Best measure	0.5	1.8	2.7	-0.5	-1.6	1.6
Body fat percentage	0.2	0.8	2.1	-0.6	1.4	-0.1
Leg fat percentage (right)	0.1	0.5	1.3	-0.4	1.2	0.3
Arm fat-free mass (right)	0.9	4.6	5.8	-2.4	1.8	2.1
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.4	-0.7	-0.2
Comparative body size at age 10	0.2	0.5	0.9	0.6	-0.3	1.0
Number of full brothers	0.6	0.7	2.1	-1.5	-0.3	0.2
Worry too long after embarrassment	2.1	3.5	5.6	-1.4	2.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.1	0.5	1.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	-0.3	-0.1	-1.3
Number of children fathered	1.7	2.0	3.2	1.5	1.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.2	0.8	-1.8	-1.0
Age at first live birth	0.4	0.7	1.8	1.3	-0.1	0.5
Pulse wave peak to peak time	0.2	0.3	0.4	-0.5	-0.3	0.6
Health satisfaction	0.4	0.6	1.1	-0.7	1.1	0.2
Shortness of breath walking on level ground	1.1	1.3	3.0	0.5	1.7	0.7
Qualifications: College or University degree	0.1	0.2	0.5	0.7	-0.3	0.3
Eye problems/disorders: None of the above	1.4	1.6	3.3	0.2	-1.8	-1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.3	0.6	-0.5	0.5
Emphysema/chronic bronchitis	0.9	1.0	2.4	0.7	1.5	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.7	0.5	-0.3
Neck or shoulder pain in last month	1.9	2.7	5.4	-0.1	-1.6	2.3
Medication: Blood pressure	0.8	1.5	3.2	0.2	-1.0	-1.8
Angina (self-reported)	0.7	0.9	2.2	0.5	-0.4	-1.5
Migraine (self-reported)	0.2	0.3	0.7	-0.2	-0.9	-0.4
Medication: Ibuprofen	0.3	0.3	0.7	0.5	0.1	0.8
Medication: Allopurinol	0.4	0.6	1.7	-0.3	-0.0	1.3
Medication: Omeprazole	0.5	0.6	1.7	-0.1	-1.3	0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.3	-0.0	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	-0.2	-0.6	-0.4
Heart disease (mother)	1.8	2.2	3.7	1.7	-0.5	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	8.1	0.3	0.4	-2.8
Whole body fat mass	0.4	1.7	3.0	-1.4	1.7	0.6
Leg fat mass (right)	0.4	1.7	2.6	-1.2	1.6	1.1
Arm predicted mass (right)	0.7	3.4	4.3	-2.1	1.6	1.8
Pulse rate, automated reading	0.6	1.8	4.6	-2.2	0.2	-0.9
Alcohol intake frequency.	0.1	0.2	0.5	0.7	0.3	0.0
Comparative height size at age 10	0.1	0.6	1.5	-1.2	0.4	-0.2
Number of full sisters	0.3	0.3	1.0	0.1	0.3	1.0
Suffer from ‘nerves’	1.2	1.8	4.8	-2.2	-0.1	-0.8
Overall health rating	0.1	0.3	0.8	-0.9	-0.4	-0.0
Chest pain or discomfort	0.1	0.2	0.4	0.1	0.7	-0.4
Had major operations	1.2	1.4	3.8	-1.9	0.5	0.4
Age at last live birth	0.4	0.6	1.3	1.1	-0.2	-0.6
Family relationship satisfaction	1.7	2.1	2.9	-1.2	1.4	1.7
Leg pain on walking	0.9	1.1	1.9	-1.2	0.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.4	1.1	-1.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	-0.4	-0.2	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	1.3	0.1	1.0
Medication: Aspirin	0.6	0.8	2.0	1.4	0.5	0.3
Supplements: Vitamin C	0.8	1.0	1.3	1.0	0.8	-1.1
Knee pain experienced in last month	0.8	1.2	2.6	-0.7	-1.6	0.7
Hypertension (Self-reported)	0.2	0.6	0.9	0.7	-0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	3.9	-1.8	-2.0	-0.3
Illnesses of father: Heart disease	1.1	1.5	2.5	1.6	0.4	-1.3
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.3	-0.0	0.3
Smoking status: Previous	0.7	1.1	1.3	0.8	1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	-0.6	0.6	0.8
Whole body fat-free mass	0.5	3.1	4.6	-1.7	1.3	2.1
Leg fat-free mass (right)	0.6	3.0	4.8	-1.3	1.6	2.2
Arm fat percentage (left)	0.1	0.5	0.8	-0.6	0.9	0.7
Average weekly red wine intake	1.2	1.8	3.6	-1.3	-1.9	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	0.5	0.3	-0.8
Mood swings	0.4	0.7	1.3	-0.3	0.7	1.2
Loneliness, isolation	0.7	1.0	2.0	-1.4	-1.0	-0.3
Long-standing illness, disability or infirmity	1.3	1.9	2.3	-1.2	-1.5	1.4
Ever had bowel cancer screening	0.5	0.5	0.6	0.7	0.7	-0.8
Diabetes diagnosed by doctor	1.0	1.6	2.7	1.6	-0.5	1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.8	-2.0	-0.9	1.7
Friendships satisfaction	0.7	0.9	2.4	-1.6	-0.3	0.3
Qualifications: nursing, teaching	0.6	1.0	1.7	1.3	-0.5	1.0
Commuting to job workplace: Walk	0.6	0.6	0.9	-0.9	1.0	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.3	-0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.1	-0.4	0.1
Medication for cholesterol	0.4	0.6	1.1	-0.2	0.8	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	3.6	-1.9	0.1	0.2
Back pain experienced in last month	1.2	1.7	4.1	0.6	-0.9	2.0
Mineral and other dietary supplements	2.8	3.8	7.2	-2.7	1.8	1.0
Breast cancer (self-reported)	0.7	0.9	1.4	0.1	1.1	-1.2
Asthma (self-reported)	1.5	3.1	9.1	-3.0	0.2	0.2
Osteoporosis (self-reported)	0.6	0.8	0.9	1.0	0.9	-0.8
Osteoarthritis (self-reported)	0.7	0.9	2.2	0.6	-1.5	-0.4
Medication: Aspirin	0.5	0.7	1.5	1.2	0.5	0.6
Medication: Gliclazide	0.5	0.6	0.6	0.8	-0.8	0.7
Illnesses of father: None of the above (group 1)	1.0	1.2	2.9	0.1	0.9	1.7
Smoking status: Current	1.9	2.9	6.9	-1.4	2.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.9	0.6	-1.7	1.0
Whole body water mass	0.6	3.5	5.0	-1.9	1.4	2.2
Leg predicted mass (right)	0.6	3.1	5.1	-1.4	1.6	2.3
Arm fat mass (left)	0.4	1.7	2.0	-1.4	1.3	1.2
Number of self-reported non-cancer illnesses	1.0	1.7	2.8	-1.4	-1.7	0.7
Average weekly champagne plus white wine intake	0.7	1.0	1.7	0.9	1.3	-0.6
Miserableness	1.1	1.9	2.9	-1.7	1.2	1.2
Guilty feelings	0.1	0.1	0.2	-0.3	0.5	0.2
Wears glasses or contact lenses	1.9	2.2	5.7	0.0	-1.0	2.4
Ever taken oral contraceptive pill	0.9	1.0	1.2	-1.1	1.1	0.8
Hearing aid user	0.0	0.1	0.1	-0.1	0.4	0.2
Mother’s age at death	0.7	0.9	1.3	1.2	0.9	-0.7
Financial situation satisfaction	1.5	1.9	4.7	-2.2	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.3	1.5	-0.9	0.2
Commuting to job workplace: Public transport	1.3	1.6	4.5	0.5	0.1	-2.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.9	-0.2	1.7	0.5
Medication: Blood pressure	0.3	0.5	1.4	1.2	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.2	-0.2	-1.5	-0.7
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.1	2.8	-1.8	-1.1
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.6	-0.5	-0.4
Medication: Bendroflumethiazide	0.4	0.6	1.0	0.8	-0.4	-1.0
Medication: Paracetamol	0.2	0.3	0.7	0.0	-0.9	0.4
Medication: Lisinopril	0.6	0.8	1.8	1.3	-0.8	0.3
Medication: Atorvastatin	0.8	1.0	1.5	1.2	-0.8	1.0
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.2	-1.1	-0.2
Alcohol drinker status: Never	0.1	0.1	0.3	0.0	-0.5	-0.2
Ever smoked	1.1	1.9	4.8	1.0	2.2	-0.1
Basal metabolic rate	0.6	3.5	4.6	-1.9	1.5	2.1
Leg fat percentage (left)	0.2	0.7	1.6	-0.6	1.3	0.5
Arm fat-free mass (left)	0.7	3.5	3.8	-1.9	1.8	1.9
Number of operations (self-reported)	0.5	0.8	1.2	-1.1	-1.0	0.4
Average weekly beer plus cider intake	0.8	1.1	3.2	-1.8	0.0	-0.4
Irritability	0.6	0.9	2.0	-0.3	1.4	0.9
Risk taking	0.5	0.7	2.0	0.1	0.1	-1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.8	1.2	0.7	1.7
Fractured/broken bones in last 5 years	0.3	0.5	1.0	0.2	0.5	1.0
Age started oral contraceptive pill	1.8	2.3	5.6	-0.4	1.0	-2.4
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.9	-0.2	0.6
Ever depressed for a whole week	0.5	0.7	1.3	0.4	1.1	0.8
Unable to work because of sickness or disability	1.8	2.3	6.7	-2.6	-0.5	0.0
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.4	0.6	0.1
Myopia	2.2	3.2	7.6	1.4	-2.8	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.3	-1.5	1.0	1.1
Cholesterol lowering medication	0.1	0.2	0.4	0.6	0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.6	-0.5	-1.6	0.2
Pain experienced in last month	1.1	1.9	3.5	0.1	1.5	-1.9
Supplements: Calcium	1.0	1.1	2.4	-0.9	-1.5	0.1
Basal cell carcinoma (self-reported)	0.7	0.9	1.4	-0.4	1.0	1.2
Heart attack/myocardial infarction (self-reported)	1.5	2.0	5.2	2.3	0.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	-1.1	-0.2	-0.4
Heart disease (siblings)	0.3	0.4	0.9	-1.0	-0.1	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.4	0.2	-0.5	1.2
Pack years of smoking	1.8	2.6	5.9	-2.4	1.4	0.2
Impedance of whole body	0.8	3.9	11.6	0.3	-0.3	-3.4
Leg fat mass (left)	0.5	2.1	3.1	-1.3	1.8	1.2
Arm predicted mass (left)	0.8	3.9	4.6	-2.0	1.8	2.1