Hub : Genes

WDR37

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0710 0.0230 1.8e-04 0.029 0.042 0.038 0.045 0.029 1.5e-04 6.0e-06 1.6e-05 2.9e-06 1.8e-04
2 GTEx Adipose Subcutaneous 0.1470 0.0530 5.0e-04 0.036 NA 0.015 NA 0.033 6.1e-04 NA 1.9e-02 NA 9.2e-04
3 GTEx Adrenal Gland 0.2557 0.0761 1.4e-04 0.151 NA 0.042 NA 0.183 4.5e-06 NA 1.2e-02 NA 3.9e-07
4 GTEx Brain Cerebellum 0.2630 0.0930 3.5e-03 0.205 NA 0.082 NA 0.159 1.1e-06 NA 2.0e-03 NA 2.0e-05
5 GTEx Breast Mammary Tissue 0.1690 0.0670 2.5e-03 0.033 NA 0.002 NA 0.017 8.3e-03 NA 2.3e-01 NA 4.5e-02
6 GTEx Breast Mammary Tissue (Male) 0.1534 0.1391 1.7e-01 0.019 NA 0.005 NA 0.022 1.1e-01 NA 2.5e-01 NA 1.0e-01
7 GTEx Breast Mammary Tissue (Female) 0.1612 0.0817 2.9e-02 -0.007 NA -0.009 NA -0.005 5.7e-01 NA 7.3e-01 NA 4.8e-01
8 GTEx Cells Transformed fibroblasts 0.1080 0.0390 8.4e-04 0.067 NA 0.044 NA 0.049 9.5e-06 NA 3.1e-04 NA 1.4e-04
9 GTEx Esophagus Muscularis 0.1920 0.0650 1.4e-03 0.014 NA 0.021 NA 0.058 4.7e-02 NA 1.9e-02 NA 2.1e-04
10 GTEx Muscle Skeletal 0.0749 0.0317 7.4e-03 0.001 NA 0.023 NA 0.014 2.3e-01 NA 2.2e-03 NA 1.4e-02
11 GTEx Nerve Tibial 0.3146 0.0528 3.4e-13 0.204 NA 0.226 NA 0.248 1.9e-14 NA 5.6e-16 NA 1.3e-17
12 GTEx Pancreas 0.1720 0.0630 2.5e-03 0.143 NA 0.015 NA 0.094 1.3e-06 NA 7.4e-02 NA 8.9e-05
13 GTEx Testis 0.1600 0.0620 7.9e-03 0.198 NA 0.171 NA 0.185 3.7e-09 NA 4.8e-08 NA 1.2e-08
14 METSIM Adipose 0.0383 0.0158 2.3e-03 0.003 0.012 0.009 0.013 0.012 9.5e-02 5.3e-03 1.4e-02 4.4e-03 5.7e-03
15 NTR Blood 0.0221 0.0090 4.5e-03 -0.001 0.004 0.000 0.004 0.001 6.6e-01 1.5e-02 2.1e-01 2.0e-02 1.4e-01
16 TCGA Prostate Adenocarcinoma 0.2321 0.0557 0.0e+00 0.244 0.260 0.246 NA 0.265 2.5e-25 4.9e-27 1.8e-25 NA 1.2e-27
17 TCGA Thyroid Carcinoma 0.1020 0.0490 3.0e-04 0.074 0.059 0.055 NA 0.068 9.8e-08 2.2e-06 4.2e-06 NA 3.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.9 1.4 2.7 -0.8 -1.2 -1.4 -0.5 -1.5 1.3 -1.3 -0.5 0.1 1.6 -1.3 -1.1 -1.6 -0.6 0.1 -1.6 -1.5
Bipolar Disorder or Schizophrenia 0.1 0.4 1.2 -0.4 -0.2 -0.7 -0.6 -0.9 0.2 -1.1 -0.7 -1.1 -0.2 -0.1 0.0 -0.6 -0.2 -0.6 -0.7 -0.1
Depressed Affect (Nagel 2018) 1.4 2.8 9.3 2.3 -1.9 3.1 1.5 1.0 2.4 1.8 2.2 0.7 0.4 -2.5 -1.7 -0.3 0.9 -0.0 0.5 1.5
Depression (Nagel 2018) 2.1 3.1 10.1 3.1 -3.1 2.8 0.0 -1.0 1.3 -0.1 0.6 -0.8 0.9 -3.2 -3.0 -0.3 -0.6 -0.2 -0.1 1.0
Intelligence (Savage-Jansen 2018) 0.4 1.2 7.0 1.8 -0.2 0.5 0.6 -0.6 -1.1 -0.7 0.7 -0.9 -2.7 -0.5 0.1 1.8 1.2 -1.0 1.0 0.1
Neuroticism (Nagel 2018) 1.1 2.7 10.8 2.4 -1.1 3.3 1.8 1.3 2.2 1.7 2.3 1.0 -0.4 -2.0 -1.2 -0.0 1.1 0.0 0.7 1.4
Schizophrenia (2018) 0.3 0.6 2.6 0.1 0.7 0.2 -0.4 0.0 -0.9 -0.3 -0.5 -1.5 -1.6 0.9 0.9 0.5 0.2 -0.9 0.4 1.1
Schizophrenia vs Biploar Disorder 0.7 0.9 2.1 0.8 1.1 1.1 -0.0 0.9 -0.7 1.2 0.0 0.3 -1.3 0.9 0.8 1.0 0.7 -1.4 0.9 1.3
Worry (Nagel 2018) 0.9 2.0 6.6 2.0 -0.5 2.6 1.9 1.3 1.6 1.4 2.3 1.4 -1.0 -1.2 -0.7 0.5 1.1 0.4 0.9 0.8
Alzheimer’s Disease (in mother) 0.5 0.6 3.5 1.4 -0.1 0.3 0.3 -0.2 -0.1 1.0 0.4 1.9 -0.5 0.2 0.2 0.6 0.6 -1.0 0.5 -0.2
Alzheimer’s Disease (in father) 0.7 0.7 3.7 -0.2 1.5 0.0 0.5 0.8 -0.1 0.9 0.3 1.0 0.5 1.9 1.5 0.3 0.6 -0.3 0.4 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 3.7 0.3 0.6 -0.4 0.2 -0.1 -0.0 0.9 0.3 1.9 0.1 1.1 0.7 0.3 0.5 -1.3 0.2 -0.7
Crohns Disease (2017) 0.3 0.6 2.3 0.9 -0.3 0.1 0.4 -0.7 -1.1 -1.5 0.5 0.5 -0.2 0.0 -0.0 1.2 -0.1 -1.1 0.9 0.6
Irritable Bowel Disease (IBD) 0.5 1.3 7.4 0.7 -0.6 -0.6 -0.9 -1.8 -1.4 -2.7 -0.7 -0.1 -0.2 -0.5 -0.9 0.7 -1.8 -0.8 -0.0 -1.2
Ulcerative Colitis (UC) 1.3 2.3 7.1 0.4 -1.3 -0.9 -1.8 -2.1 -0.8 -2.3 -1.5 -0.3 0.4 -1.5 -2.0 -0.4 -2.6 -0.4 -1.0 -2.7
Major Depression (MDD) 0.7 0.8 5.2 0.7 0.1 0.6 0.8 0.3 1.6 0.3 0.9 0.9 2.3 -0.0 0.3 -0.2 1.4 -0.6 -0.1 -0.2
Reaction Time 0.6 1.1 7.0 2.6 -0.5 1.3 -0.2 0.1 -1.0 0.7 -0.0 -0.6 0.4 0.3 -0.7 1.0 -1.8 0.3 0.9 1.2
Verbal and Numeric Reasoning (VNR) 0.7 1.8 9.8 1.4 0.4 -0.0 0.6 -0.6 -1.5 -1.2 0.6 -1.7 -3.1 0.4 0.4 2.1 1.3 -1.0 1.6 0.4
Breast Cancer 0.3 0.7 4.7 0.4 0.0 0.8 0.7 1.1 0.1 2.2 0.6 0.0 0.6 0.2 0.5 0.5 0.8 -0.5 0.8 1.1
Ovarian Cancer 1.7 2.3 10.5 0.6 -1.7 -0.6 -1.5 -2.0 -0.5 -0.9 -1.5 -0.9 -0.2 -1.9 -2.0 -0.4 -2.0 -3.2 -0.8 -1.3
Prostate Cancer 2.6 3.7 8.9 -2.9 3.0 -1.1 1.5 2.0 1.9 -0.2 0.8 -0.2 2.4 3.0 3.0 -1.1 0.9 2.8 -0.4 0.8
Age at First Birth 0.8 1.1 2.9 -1.2 0.9 -1.4 -0.7 -0.7 1.3 -0.8 -0.8 -0.7 1.5 1.0 1.0 -1.7 -0.3 -0.5 -1.6 -1.0
Bipolar Disorder (2011) 0.5 0.5 4.6 -0.2 0.1 0.5 0.5 0.7 0.6 0.0 0.2 -0.9 2.1 0.4 0.3 -0.4 -0.0 0.6 0.0 0.5
Body Mass Index (BMI) (2010) 1.0 1.3 5.0 -0.6 -0.7 -0.9 -1.5 -1.3 -0.5 -0.9 -1.4 -1.1 1.2 -0.5 -0.5 -1.0 -1.7 -2.2 -1.3 -0.7
Coronary Artery Disease (CAD) 0.6 0.7 2.1 0.2 -1.2 0.9 -0.6 -0.5 0.0 -0.1 -0.4 -1.2 1.1 -1.5 -1.2 -0.8 -0.9 -0.7 -0.4 0.2
Crohns Disease (2012) 0.4 0.6 1.5 0.9 -0.4 0.9 0.7 0.0 -0.4 -0.9 0.8 1.1 0.5 -0.6 -0.3 1.2 -0.6 -0.8 1.2 0.9
Mean Putamen Volume 0.3 0.4 1.9 0.5 0.3 0.0 -0.1 0.6 -0.3 -0.1 -0.1 -1.2 0.4 1.1 0.9 -0.3 -0.2 1.4 -0.1 0.7
Fasting Glucose 0.6 0.7 2.2 -0.2 0.1 0.6 1.2 1.2 -0.4 0.8 1.3 -1.5 -0.3 0.2 -0.0 1.2 0.7 1.0 1.2 0.5
HbA1C 0.8 0.9 2.5 1.3 -1.1 1.6 0.2 0.3 -1.3 1.1 0.4 0.1 -0.1 -1.1 -1.1 1.2 -0.6 -0.6 1.0 0.7
HDL Cholesterol 1.3 2.2 5.7 -1.6 -0.9 -2.4 -1.9 -1.9 -0.2 -1.8 -2.0 -0.1 0.1 -0.4 -0.8 -1.5 -2.0 -0.3 -1.9 -1.9
LDL Cholesterol 0.2 0.3 1.4 -0.8 0.4 -0.4 -0.4 0.1 0.2 0.3 -0.5 -0.3 1.2 0.6 0.4 -0.5 0.2 -0.1 -0.7 -0.5
Lupus 0.8 1.2 4.2 1.7 0.0 -0.0 -1.5 -1.3 -1.3 -1.3 -1.5 -2.0 0.8 0.1 0.5 -0.0 -0.3 0.2 -0.1 1.9
Neuroticism (2016) 0.7 1.0 3.6 1.8 0.3 1.9 0.6 1.2 -0.1 1.3 0.7 -0.3 -0.1 0.4 0.4 0.3 1.2 0.8 0.7 1.7
Primary Biliary Cirrhosis 1.7 2.4 12.3 1.1 -1.3 -0.7 -1.6 -2.5 -2.0 -3.5 -1.6 -1.7 0.5 -0.4 -0.8 0.6 -1.9 -1.3 -0.1 0.6
Rheumatoid Arthritis 0.4 0.6 3.3 0.3 -0.3 0.2 -0.8 -0.9 -0.1 -0.8 -0.8 -1.8 0.0 -1.3 -0.8 -0.7 -0.6 -0.5 -0.8 -0.3
Schizophrenia (2014) 0.2 0.5 1.8 -0.4 0.1 -0.5 -0.9 -1.1 -0.3 -1.3 -1.0 -1.0 -0.7 0.2 0.0 -0.2 -0.7 -1.2 -0.5 -0.2
Triglycerides 0.4 0.6 4.4 -0.3 0.0 -0.3 -0.2 0.1 1.0 -1.2 -0.2 -1.0 2.1 0.4 -0.1 -1.0 -0.1 0.4 -1.0 -0.1
Type 2 Diabetes (T2D) (2012) 2.0 2.3 6.9 -0.3 -1.2 -0.8 -1.9 -1.7 -0.2 -1.3 -1.8 0.2 1.7 -1.0 -1.4 -1.7 -2.6 -1.8 -2.2 -1.1
Ulcerative Colitis 1.0 1.5 5.0 0.3 -0.2 -1.1 -1.5 -1.6 -1.3 -2.1 -1.2 -1.3 -0.4 -0.4 -0.6 0.8 -2.2 -0.9 0.1 -1.5
Blood Eosinophil Count 3.6 27.8 108.2 -5.4 9.8 -3.4 4.0 5.5 -1.4 1.1 2.2 1.2 -1.5 10.4 10.1 2.6 4.8 4.9 2.8 2.6
Blood Platelet Count 0.0 0.6 2.7 0.9 0.5 0.1 0.6 -0.1 -1.3 -1.6 0.4 0.2 -0.5 0.5 0.5 1.2 -0.5 -0.1 0.8 0.8
Blood Red Count 0.1 1.3 5.7 -0.4 0.4 -1.4 -0.9 -1.0 -2.3 -0.6 -0.9 -0.8 -1.7 0.2 0.2 1.1 -0.9 -2.4 0.7 0.2
Blood White Count 0.2 1.5 4.8 -0.3 1.6 -0.6 1.6 0.7 0.1 -0.6 1.2 1.2 -0.1 2.2 2.1 0.8 2.1 0.9 0.6 1.0
Heel T-Score 0.5 3.8 9.9 -0.2 3.1 -0.1 2.3 2.4 -2.1 1.0 2.0 0.7 -1.7 2.7 2.8 2.8 0.5 1.6 2.4 0.2
BMI 1.5 8.6 22.1 -1.5 -1.9 -2.7 -4.1 -3.6 0.7 -3.3 -4.2 -0.5 3.2 -1.5 -2.0 -3.6 -4.7 -0.1 -4.1 -2.5
Height 0.1 2.5 11.6 2.3 -2.6 2.5 -0.3 -0.9 0.5 0.6 0.2 1.2 0.7 -3.4 -2.7 -0.3 -0.6 -1.3 0.0 0.4
Waist Hip Ratio (WHR) 0.2 1.0 3.5 1.1 -1.4 1.9 1.0 0.9 0.7 1.4 1.2 0.7 -1.0 -1.0 -0.7 0.9 0.1 0.5 1.1 0.6
Systolic Blood Pressure 0.3 1.6 3.8 -1.8 1.9 -0.1 0.9 1.9 1.4 1.8 0.6 1.7 -0.4 1.4 1.7 -1.0 0.6 1.1 -0.2 0.5
Smoking Status 0.7 1.7 6.1 1.5 -1.7 1.1 -0.6 -1.1 0.6 -0.2 -0.2 -0.7 -1.8 -2.5 -2.1 -0.7 0.3 -2.4 -0.8 -0.4
Allergy or Eczema 0.3 0.9 3.2 1.4 -0.3 0.3 -0.7 -1.0 -1.5 -1.2 -0.7 -1.1 -0.2 -0.2 -0.2 0.8 -0.7 -1.8 0.5 1.1
Cardiovascular Disease 0.1 0.4 4.2 -0.4 -0.3 -0.2 -0.2 -0.1 1.0 0.2 -0.1 -0.2 2.0 0.1 0.1 -0.9 0.2 -0.8 -0.7 -0.1
Hypothyroidism (self reported) 0.2 0.5 1.4 -0.0 0.4 -0.7 -0.7 -0.7 -1.1 -1.2 -0.6 -1.1 0.2 0.7 0.8 0.6 -1.0 -0.7 0.0 -0.1
Respiratory disease 1.3 2.8 5.8 -0.8 -1.7 -0.6 -1.9 -1.9 1.2 -1.5 -1.6 -0.4 1.8 -1.9 -1.9 -1.9 -2.4 -1.3 -2.3 -1.7
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.5 -1.6 -0.6 0.0 -0.0 0.5 1.5 0.6 0.1 -0.0 0.3 -1.0 -1.1 -1.2 -1.0 -1.0 -0.8 -1.0
Lung FEV1/FVC ratio 0.8 3.8 10.4 -2.2 1.8 -3.0 -2.5 -1.6 -1.5 -3.2 -2.8 -0.2 0.7 1.8 1.4 -1.1 -2.5 -0.0 -1.9 -1.4
Lung FVC 1.1 5.6 11.1 0.2 2.3 1.1 3.1 3.0 -1.0 3.1 2.9 1.7 -3.1 1.9 2.3 3.2 2.7 0.9 3.3 0.7
Neuroticism 1.6 3.8 15.6 3.6 -1.0 3.9 2.0 1.6 1.2 2.0 2.4 1.4 -0.1 -1.4 -0.7 1.0 1.3 -0.0 1.7 2.9
Chronotype (morning person) 0.4 0.8 2.8 -0.7 1.3 -1.3 -0.6 0.2 0.2 0.1 -0.8 0.0 1.3 1.5 0.9 -0.7 -1.7 -0.3 -0.6 -0.8
Hair Pigment 0.0 0.6 3.3 -0.7 0.7 -0.4 -0.4 -0.2 0.5 -0.7 -0.6 -0.5 1.8 0.4 0.9 -1.0 -0.3 -0.5 -0.8 0.7
Tanning 0.1 1.0 3.9 1.4 -1.1 0.6 0.7 -0.3 0.1 1.1 0.9 0.7 -0.9 -2.0 -1.4 0.8 0.4 0.9 0.8 -0.9
Hand grip strength (left) 0.7 1.8 5.5 -0.2 -0.6 -1.8 -1.5 -1.9 -2.3 -1.6 -1.7 -2.3 -0.9 -0.2 -0.3 0.7 -0.4 -1.9 -0.1 -0.3
Number of treatments/medications taken 0.4 0.7 2.1 0.2 0.7 -0.3 -0.8 -0.1 -1.0 -0.5 -0.9 -0.7 0.3 1.2 1.3 0.1 -0.9 1.4 0.1 1.4
Average weekly spirits intake 1.7 2.1 8.8 1.5 -2.5 1.0 -1.2 -1.3 0.2 -0.2 -0.8 0.1 0.2 -3.0 -2.8 -0.8 -0.7 -1.8 -0.7 -0.9
Sensitivity / hurt feelings 1.8 3.1 7.7 0.8 1.0 2.8 2.3 2.5 2.1 2.5 2.5 1.9 0.3 0.4 1.3 0.3 1.6 -0.1 1.2 2.3
Frequency of depressed mood in last 2 weeks 1.7 2.4 7.1 2.7 -2.5 2.1 0.0 -0.9 2.0 -0.3 0.6 0.0 1.1 -2.6 -2.5 -1.0 -0.9 0.6 -0.7 1.0
Hearing difficulty/problems: Yes 0.9 1.4 6.5 -0.7 -0.9 1.3 -0.2 0.3 2.5 0.4 0.0 1.2 0.7 -1.2 -1.3 -2.0 -0.8 -0.9 -1.6 -0.6
Relative age of first facial hair 0.5 1.0 3.4 -0.2 -0.3 -0.4 -1.8 -1.1 -0.1 -0.0 -1.7 -1.6 1.2 -0.6 -0.9 -0.9 -0.7 -1.0 -1.2 -0.8
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.2 0.9 -1.1 0.5 -0.9 -0.9 -0.7 -0.6 -0.6 -1.0 0.6 -1.7 -1.8 0.4 -1.2 -1.6 -0.1 -0.6
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.3 0.1 -0.5 1.5 0.4 0.4 1.3 0.9 0.7 0.9 0.8 -1.1 -1.1 -1.0 -0.6 -0.2 -0.7 -0.5
Ever had hysterectomy (womb removed) 1.5 1.7 6.5 -0.0 -1.9 0.7 -0.8 -0.9 1.1 0.2 -0.6 -0.1 0.8 -2.5 -2.4 -1.5 -0.4 -2.3 -1.3 -0.5
Systolic blood pressure, automated reading 0.2 0.7 2.1 -1.2 1.4 -0.0 0.4 1.2 0.7 1.0 0.3 1.4 -1.2 0.5 0.8 -0.7 -0.4 0.6 -0.3 -0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 3.2 0.5 -0.7 1.1 -0.0 0.0 -0.4 -0.8 0.1 -0.3 1.8 0.0 -0.1 0.2 -0.7 -1.0 0.3 1.6
Angina 1.3 1.8 3.4 -0.0 1.3 1.6 1.8 1.6 0.2 1.2 1.8 0.8 -1.3 0.8 1.6 0.9 1.5 -1.2 1.4 1.9
Medication for hormone replacement therapy 0.5 0.5 1.7 0.9 -0.6 0.6 0.5 -0.2 0.3 -0.8 0.8 0.6 -0.8 -1.2 -0.9 0.3 0.0 1.3 0.1 -0.5
Vitamin and mineral supplements 0.8 1.1 3.1 -0.2 -1.5 0.4 -0.8 -0.9 0.5 0.2 -0.6 0.1 0.1 -1.6 -1.8 -1.2 -0.6 -1.8 -1.4 -1.1
Supplements: Zinc 0.4 0.5 2.0 0.5 -0.2 0.3 0.4 0.1 -1.4 0.1 0.3 -0.5 0.1 0.4 0.3 0.9 -0.1 1.3 1.0 1.2
Medication: Co-codamol 0.7 0.8 5.1 1.4 0.2 0.7 1.1 0.6 0.0 0.4 1.1 2.3 -0.5 -0.2 0.3 1.1 0.6 0.5 1.0 0.4
Medication: Metformin 0.3 0.4 2.5 -0.7 -0.1 0.0 -0.6 0.2 0.6 0.4 -0.5 0.2 1.0 -0.2 -0.5 -0.8 -1.6 -0.9 -0.6 0.1
Diabetes (father) 1.9 2.3 6.7 0.7 -1.9 -0.9 -1.8 -2.6 -1.0 -1.9 -1.7 -1.5 0.0 -1.9 -2.0 -0.1 -1.4 -2.0 -0.8 -1.1
Diabetes (mother) 0.2 0.3 1.5 0.7 0.1 0.2 0.2 -0.1 -0.2 -0.2 0.3 -0.3 -0.1 0.8 0.6 0.6 -0.7 0.1 0.6 1.2
Severe depression (siblings) 4.6 5.1 10.0 1.8 1.6 2.2 2.5 2.5 -1.4 1.9 2.5 1.6 -3.0 1.4 2.0 2.9 2.5 1.7 3.2 2.6
Pack years adult smoking proportion 1.4 2.2 5.2 -0.4 -1.7 -0.3 -2.2 -2.0 0.7 -1.0 -2.1 -0.7 0.7 -1.8 -1.7 -2.1 -0.8 -0.8 -2.3 -0.9
Impedance of leg (right) 1.2 5.6 16.3 2.6 -0.8 4.0 3.4 2.8 0.7 2.4 3.7 0.9 -0.9 -0.8 -0.4 2.1 3.0 -0.8 2.8 2.9
Leg fat-free mass (left) 0.5 2.4 4.9 -1.7 0.3 -2.0 -2.0 -1.6 0.5 -1.2 -2.2 0.7 2.1 0.1 0.1 -2.0 -2.0 1.0 -2.2 -1.3
Trunk fat percentage 0.1 0.4 2.4 0.2 -0.1 0.4 -0.0 0.1 -1.0 -0.4 -0.2 1.5 0.9 -0.2 0.3 0.4 -1.3 0.6 0.3 0.8
Hand grip strength (right) 1.1 2.9 8.5 0.3 -1.4 -2.2 -2.5 -2.9 -1.8 -2.3 -2.4 -2.2 -0.5 -1.0 -1.5 -0.3 -1.0 -1.1 -1.0 -1.5
Townsend deprivation index at recruitment 0.7 0.9 4.8 -0.0 0.1 -0.6 -0.1 -0.5 1.5 -1.5 -0.0 1.0 2.2 0.3 0.2 -1.5 -0.3 0.8 -1.3 -0.1
Current tobacco smoking 0.3 0.5 2.4 0.4 -0.4 0.2 -0.1 -0.3 1.6 -0.2 0.1 0.5 -0.0 -0.8 -0.3 -1.5 1.1 0.1 -1.1 0.2
Average weekly fortified wine intake 0.5 0.6 2.6 -0.9 0.4 -0.6 -0.4 -0.3 -0.3 -0.8 -0.6 1.5 -1.0 0.3 -0.1 0.2 -0.6 -0.6 -0.2 -1.6
Maternal smoking around birth 0.4 0.5 2.8 -0.4 -0.2 -0.0 0.3 0.2 1.4 0.6 0.4 1.7 -0.5 -0.4 -0.1 -0.7 1.6 0.2 -0.2 -0.1
Fed-up feelings 1.2 2.1 7.2 1.5 -2.0 1.6 -0.0 -0.3 2.7 0.5 0.5 0.0 1.7 -2.6 -2.0 -1.8 -0.3 -0.7 -1.3 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.9 1.7 -0.8 1.0 0.2 -0.5 1.3 -0.6 0.5 0.8 1.0 -1.0 -0.9 -0.4 0.3 0.7 -0.3 0.5
Relative age voice broke 1.1 1.7 4.6 0.1 -0.7 -0.5 -2.0 -2.1 0.4 -0.7 -1.7 -1.6 0.5 -1.4 -1.2 -1.7 -0.4 -1.8 -1.8 -0.7
Taking other prescription medications 0.3 0.5 1.8 -0.2 0.1 -0.8 -0.9 -0.7 -0.1 -1.0 -0.8 0.3 0.9 0.1 0.0 -0.6 -1.3 1.2 -0.6 0.2
Age when periods started (menarche) 0.9 2.2 7.9 0.9 -2.7 -0.3 -1.4 -1.9 0.1 -1.1 -1.1 -0.6 1.8 -2.5 -2.8 -0.8 -0.7 -1.4 -0.7 -0.8
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 3.1 -1.8 0.3 -1.0 -0.1 0.1 1.1 -0.5 -0.2 -0.4 0.7 -0.1 0.0 -1.2 -0.7 -0.1 -1.1 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.5 3.7 -1.1 1.8 -0.2 1.9 1.9 0.6 0.7 1.8 0.8 -0.7 1.5 1.5 0.6 0.7 1.3 0.8 -0.2
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 6.9 2.6 -0.8 2.0 1.5 1.0 0.9 1.8 1.8 1.1 0.1 -1.2 -0.8 0.9 0.7 1.0 1.1 0.9
Qualifications: CSEs or equivalent 0.3 0.4 1.7 1.3 -0.3 0.9 -0.1 0.4 1.1 0.6 0.2 -0.1 -0.1 -0.8 -0.6 -0.8 -0.3 -0.0 -0.5 0.4
Serious illness, injury or assault to yourself 0.4 0.5 1.8 -0.4 1.3 -0.8 0.1 0.2 -0.2 -0.2 0.0 -0.0 -0.4 1.3 1.3 0.3 0.4 1.1 0.4 0.7
High blood pressure 0.3 0.7 2.0 0.5 1.2 0.4 0.4 0.9 -0.9 1.1 0.2 0.4 -0.6 1.4 1.2 0.8 0.8 -0.0 1.0 1.0
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.6 1.1 0.2 -0.7 -1.0 -1.1 -1.4 -1.6 -1.0 -1.6 0.1 0.9 0.5 0.6 -0.9 -1.0 -0.0 0.3
Multivitamins +/- minerals 1.7 2.2 10.4 -0.0 1.6 -0.1 1.3 1.6 -0.6 0.5 1.0 -0.1 0.2 2.0 2.2 1.4 1.2 3.2 1.7 1.6
Stomach or abdominal pain in last month 2.7 3.4 8.6 0.9 1.0 1.8 2.4 2.6 1.5 2.8 2.4 2.9 -1.5 0.9 1.1 0.8 1.6 2.4 1.4 1.1
Supplements: Glucosamine 1.3 1.6 3.5 -1.7 1.8 -0.8 1.8 1.2 -0.5 -0.3 1.4 0.7 -0.9 1.7 1.9 1.4 0.7 1.3 1.3 0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.8 0.4 -0.3 -1.1 -0.9 -1.2 -0.7 -0.9 -0.8 -1.5 -0.4 -0.3 -0.3 0.2 -1.0 -1.7 -0.3 -0.6
Medication: Atenolol 0.3 0.3 1.9 -0.2 -0.4 0.0 -0.9 -0.3 -0.8 0.0 -0.9 0.1 0.3 -0.3 -0.6 -0.5 -1.4 -0.2 -0.4 -0.3
Medication: Levothyroxine sodium 0.4 0.7 1.5 -0.7 0.1 -0.7 -0.9 -1.0 0.7 -1.2 -0.9 -1.1 0.5 0.3 0.6 -1.0 -1.1 0.2 -1.2 -0.5
Sitting height 0.2 1.4 4.6 -0.0 -0.5 1.7 1.7 1.1 1.6 0.9 1.6 2.1 1.1 -0.7 -0.1 -0.2 1.8 0.2 0.2 0.5
Chronic bronchitis/emphysema (father) 1.6 1.9 5.7 0.7 -0.3 1.5 2.2 1.6 1.4 1.6 2.4 1.3 -1.7 -1.1 -1.0 0.7 1.5 1.0 1.0 -1.0
High blood pressure (mother) 6.1 8.6 19.8 -0.2 3.9 1.2 2.7 3.9 -1.0 3.4 2.5 1.1 -2.1 3.8 4.4 2.6 3.7 2.2 3.1 3.6
Body mass index (BMI) 0.7 3.0 9.9 -1.1 -0.2 -2.1 -2.6 -1.9 -0.6 -2.0 -2.8 0.0 1.9 -0.2 -0.3 -1.7 -3.1 0.2 -2.2 -1.2
Impedance of leg (left) 0.9 4.5 14.6 2.4 -1.1 3.8 3.0 2.5 1.0 2.3 3.3 1.1 -0.9 -1.1 -0.9 1.7 2.2 -1.0 2.3 2.3
Leg predicted mass (left) 0.4 2.2 4.5 -1.7 0.3 -1.9 -1.9 -1.5 0.5 -1.1 -2.1 0.8 2.1 0.1 0.2 -2.0 -1.9 0.9 -2.1 -1.3
Trunk fat mass 0.1 0.6 2.9 -0.2 -0.1 0.0 -0.6 -0.3 -0.6 -0.5 -0.8 1.6 1.5 -0.2 0.1 -0.4 -1.7 0.5 -0.5 0.3
Waist circumference 0.4 1.3 4.7 0.1 -0.9 -0.0 -1.4 -0.9 0.4 -0.9 -1.4 1.2 1.9 -0.9 -0.7 -1.4 -2.2 0.9 -1.4 -0.1
Number of incorrect matches in round 0.3 0.5 2.0 1.4 -0.5 0.0 -0.5 -0.8 -0.6 -0.7 -0.5 0.7 0.3 0.2 -0.2 0.1 -0.9 1.3 0.1 0.6
Past tobacco smoking 0.8 1.5 5.0 -1.1 1.4 -1.1 0.4 0.4 0.3 -1.0 0.1 0.4 2.2 2.0 2.0 -0.4 0.1 2.2 -0.2 1.0
Alcohol usually taken with meals 0.7 1.2 3.5 -1.0 1.5 -0.7 1.3 0.8 -0.2 -0.1 1.0 0.9 0.3 1.9 1.9 0.9 1.9 0.4 1.0 -0.1
Nervous feelings 0.5 1.0 4.4 1.4 -0.9 1.4 0.4 0.1 2.1 0.5 0.9 0.6 -0.0 -1.7 -1.3 -0.9 0.7 -0.0 -0.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.5 1.3 -1.4 1.3 -0.1 -0.5 1.3 0.4 0.3 -0.1 0.5 -1.9 -1.7 -0.8 0.7 -0.5 -0.5 0.5
Hearing difficulty/problems with background noise 0.7 1.1 5.2 -0.2 -0.9 1.2 0.0 0.3 2.3 0.4 0.4 1.8 1.2 -1.1 -0.9 -1.2 -0.4 -1.2 -1.1 -0.8
Hair/balding pattern: Pattern 2 0.7 0.9 3.7 1.9 -1.1 0.4 -0.5 -0.0 -0.3 -0.1 -0.2 -1.2 0.8 -1.1 -0.9 0.3 -1.9 0.9 0.3 1.1
Had menopause 0.4 0.5 1.6 -0.4 0.7 1.3 0.9 0.8 0.5 0.9 1.0 1.0 0.1 0.3 0.2 0.1 0.9 -0.6 0.4 0.4
Had other major operations 0.8 1.0 2.4 -0.9 1.1 -1.4 -1.3 -0.9 0.0 -0.8 -1.6 -1.0 0.3 1.3 1.4 -0.9 -0.1 -0.6 -0.9 0.1
Forced vital capacity (FVC) 0.4 1.5 4.8 -0.1 0.6 1.3 1.8 1.7 1.9 2.2 1.8 1.5 -0.0 0.1 0.5 -0.2 1.0 1.0 0.5 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.2 1.1 0.0 1.1 1.1 -0.6 0.2 1.1 -0.1 -1.4 0.9 0.9 0.9 0.5 0.8 1.0 0.3
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 7.8 -0.3 2.4 0.6 2.2 1.9 2.1 0.6 2.1 0.7 -0.1 1.6 2.1 0.3 2.8 1.6 0.6 0.8
Qualifications: None of the above 0.7 1.4 4.5 -0.2 -1.1 2.1 0.4 1.1 1.2 1.1 0.3 2.1 1.5 -1.3 -1.3 -1.3 -1.3 0.8 -0.6 0.4
Financial difficulties in last 2 years 0.3 0.5 2.6 0.4 -0.3 -0.3 0.4 -0.3 0.6 -0.9 0.5 1.0 0.6 -0.5 -0.2 -0.1 1.6 1.2 0.1 -0.2
Mouth/teeth dental problems 1.9 2.9 11.3 -1.1 3.1 -1.2 1.0 1.6 -1.3 0.7 0.5 -0.0 -0.1 3.4 2.8 1.7 1.0 2.0 1.6 0.8
Heart attack 1.7 2.2 7.1 0.3 1.1 0.9 0.8 1.3 -2.7 1.6 0.6 -0.8 -0.4 1.7 1.2 2.2 -0.1 -1.6 2.2 2.3
Allergy 0.5 1.1 2.6 -1.1 0.7 0.6 1.4 1.6 0.6 1.6 1.2 0.9 -0.6 0.5 0.7 -0.0 1.5 1.5 0.6 0.9
Pain all over the body in last month 0.3 0.3 1.6 0.5 0.3 0.8 0.0 -0.2 -0.8 -0.2 0.2 0.2 -1.3 -0.3 -0.5 0.9 -0.4 -0.4 0.4 -0.2
Diabetes (self-reported) 0.5 0.8 6.5 -0.8 -0.4 -0.8 -1.0 -0.7 -0.2 -0.1 -0.9 -0.7 -0.2 -0.2 -0.7 -0.5 -1.1 -2.5 -0.7 -0.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.8 0.7 1.5 -0.2 -0.5 -0.2 -0.9 -1.7 -0.7 -0.4 1.3 1.6 1.6 0.3 0.1 1.1 -0.1 1.6
Medication: Ramipril 0.5 0.6 1.9 0.7 -1.0 0.2 0.3 0.5 -1.4 0.9 0.1 -0.1 0.3 0.3 -0.1 1.2 0.5 0.7 1.2 1.2
Medication: Simvastatin 0.3 0.4 1.3 -0.4 0.1 -0.6 -0.8 -0.4 -1.0 -0.1 -1.0 -0.5 -0.5 0.7 0.4 -0.0 -1.1 -0.6 0.1 0.8
Fluid intelligence score 0.3 0.5 2.7 0.9 -0.5 0.4 0.5 -0.1 -0.2 0.5 0.7 -0.3 -1.7 -0.4 -0.5 1.0 0.8 -0.8 0.8 -0.7
Illnesses of siblings 0.8 1.1 4.0 -2.0 0.2 -1.0 -0.3 -0.4 1.9 -0.6 -0.3 -0.6 0.1 -0.3 0.0 -1.8 -0.4 -0.1 -1.8 -1.6
Neuroticism score 1.0 2.1 7.2 2.0 -0.9 2.7 1.4 1.2 2.5 1.5 1.8 1.2 0.0 -1.5 -1.0 -0.5 0.4 0.4 0.2 1.5
Weight 0.4 2.2 6.5 -0.9 -0.4 -1.2 -2.1 -1.6 -0.1 -1.5 -2.3 0.8 2.3 -0.5 -0.4 -1.8 -2.5 0.2 -2.0 -0.7
Impedance of arm (right) 0.6 2.7 7.2 1.5 -0.4 2.6 2.4 1.3 -0.5 0.8 2.7 0.8 -1.7 -1.1 -0.3 2.3 1.6 -0.8 2.3 1.6
Arm fat percentage (right) 0.2 0.9 4.6 -0.4 -0.3 -0.8 -1.0 -1.0 -0.5 -1.5 -1.2 0.8 1.2 -0.7 -0.3 -0.6 -2.1 0.1 -1.0 -0.6
Trunk fat-free mass 0.4 2.1 5.6 -1.7 -0.0 -1.6 -1.6 -1.3 1.3 -1.1 -1.7 0.6 2.3 -0.1 -0.3 -2.4 -1.2 -0.0 -2.3 -1.6
Hip circumference 0.4 1.7 5.9 -0.8 0.3 -0.7 -1.4 -1.0 0.8 -1.5 -1.6 0.7 2.4 0.1 0.4 -2.0 -1.8 0.7 -2.1 -0.3
Time employed in main current job 1.7 1.9 7.0 -1.9 2.7 -1.1 0.8 1.1 0.3 1.2 0.4 0.2 -1.5 2.2 2.3 0.4 2.0 -0.0 0.3 -0.4
Alcohol intake versus 10 years previously 0.6 0.9 4.3 -1.5 1.1 -2.1 -0.3 -0.3 -0.3 -1.3 -0.6 -0.2 0.0 1.4 1.7 0.0 -0.0 -0.8 -0.0 0.4
Father’s age at death 0.4 0.5 1.8 -0.1 1.0 0.4 0.5 0.1 -0.5 -0.3 0.6 0.7 -1.3 0.8 0.7 0.7 0.6 -0.8 0.8 0.9
Worrier / anxious feelings 1.0 1.8 5.5 1.4 0.8 1.5 2.3 1.6 0.9 1.2 2.3 1.1 -0.1 0.7 0.9 1.2 1.7 0.3 1.5 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.1 3.4 1.9 -1.5 1.6 -0.0 -0.1 -0.1 1.3 0.4 0.2 -0.4 -1.6 -1.6 0.9 -0.2 -1.1 0.5 -0.0
Falls in the last year 0.9 1.2 6.7 0.0 -0.7 0.0 0.2 -0.0 2.1 -0.3 0.3 1.0 2.6 -1.0 -0.6 -1.5 -1.4 1.5 -0.9 0.2
Hair/balding pattern: Pattern 3 1.8 2.7 8.2 -1.6 2.4 -0.6 1.7 1.5 1.3 0.9 1.4 2.4 0.6 2.3 1.7 -0.2 2.9 2.2 0.5 0.2
Number of live births 0.7 1.0 3.6 0.5 -1.2 0.9 -0.1 -0.2 1.9 0.4 0.2 -0.0 -0.8 -1.8 -0.9 -1.8 -1.0 0.4 -1.1 0.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.0 -1.2 1.4 0.1 1.0 1.3 1.4 1.4 0.9 1.2 0.3 0.9 1.2 -0.5 0.4 0.7 -0.2 0.2
Pulse rate 0.6 1.1 3.6 -0.2 1.1 0.8 0.8 1.9 0.3 1.3 0.6 0.4 -1.7 1.5 1.3 0.4 0.4 0.2 0.8 1.5
Happiness 1.3 1.6 6.1 -0.3 -0.7 -1.1 -1.1 -1.0 2.5 -1.5 -0.9 -0.8 1.2 -1.3 -1.2 -2.1 -0.8 0.6 -1.9 -0.4
Noisy workplace 0.5 0.6 2.1 1.3 -0.9 1.1 -0.1 0.4 -0.6 -0.2 0.2 -1.1 0.6 -0.2 -0.4 0.6 -1.0 -0.5 0.5 1.5
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.1 -0.1 1.9 -1.6 0.2 -0.4 -0.5 -1.8 0.0 -0.6 -1.4 2.0 1.8 0.5 0.5 1.1 0.3 0.1
Serious illness, injury or assault of a close relative in last 2 years 5.4 6.2 12.5 2.9 0.9 3.1 3.4 3.0 -0.3 2.2 3.4 2.2 -0.8 1.3 1.8 2.6 2.4 2.0 3.0 3.5
Mouth/teeth dental problems: Dentures 1.6 2.7 8.5 1.1 -2.3 0.8 -1.7 -2.0 0.1 -1.4 -1.4 -1.9 -0.2 -2.4 -2.1 -1.4 -1.2 -2.9 -1.4 -0.1
Asthma 0.7 1.4 3.5 -0.8 -0.5 -0.8 -1.6 -1.2 0.9 -0.7 -1.5 -0.6 0.9 -1.1 -0.8 -1.6 -1.9 -0.5 -1.7 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 4.3 -0.1 1.1 0.9 1.0 1.2 0.3 1.0 0.9 0.1 0.3 1.0 1.6 0.5 0.7 0.3 0.7 2.1
Medication: Cholesterol lowering 0.7 1.1 2.9 1.7 -0.1 1.3 0.5 0.3 -1.4 1.0 0.6 0.4 -0.9 -0.1 0.2 1.6 0.4 -1.3 1.7 1.4
Depression (self-reported) 0.4 0.5 1.9 -0.3 1.3 -0.6 -0.2 -0.0 0.2 -0.2 -0.3 0.8 -0.4 1.2 1.4 -0.2 0.5 0.9 -0.4 0.4
Medication: Lansoprazole 0.3 0.4 1.2 0.6 -0.1 0.8 0.9 0.7 0.4 0.7 1.1 0.5 0.3 -0.2 -0.3 0.9 0.1 0.2 0.7 -0.4
Prospective memory result 1.6 1.9 10.7 -0.1 -0.6 1.5 1.6 1.5 2.2 0.8 1.6 2.3 0.5 -0.1 0.1 -0.7 -0.0 3.3 -0.1 1.0
Lung cancer (father) 0.4 0.5 2.0 0.1 -0.7 0.9 0.8 0.5 1.4 0.5 1.0 0.5 0.2 -0.7 -0.7 -0.6 0.7 0.5 -0.2 -0.1
Illnesses of mother 4.2 5.2 16.2 -0.8 -2.3 -1.7 -2.7 -3.0 0.6 -2.5 -2.5 -1.4 1.1 -2.2 -2.7 -1.9 -2.7 -0.7 -2.6 -4.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.1 -1.5 2.0 -0.5 0.8 1.4 0.3 1.2 0.6 0.7 0.4 1.4 1.7 -0.1 -0.0 1.4 -0.0 -0.1
Pulse wave Arterial Stiffness index 1.2 1.4 3.8 -1.8 1.7 0.2 1.3 1.9 1.4 0.6 1.0 1.4 -0.1 1.3 1.4 -0.3 0.9 1.4 0.3 0.6
Impedance of arm (left) 0.6 2.9 6.7 2.0 -0.9 2.5 2.3 1.0 -1.0 1.0 2.6 0.5 -1.6 -1.4 -0.5 2.6 1.8 -0.3 2.5 1.4
Arm fat mass (right) 0.5 2.0 6.8 -0.7 -0.5 -1.2 -1.9 -1.6 -0.1 -1.6 -2.1 0.7 2.1 -0.7 -0.6 -1.5 -2.6 -0.1 -1.9 -1.0
Trunk predicted mass 0.3 2.0 5.2 -1.5 -0.1 -1.5 -1.6 -1.3 1.3 -1.1 -1.7 0.7 2.3 -0.2 -0.3 -2.3 -1.1 0.1 -2.2 -1.6
Standing height 0.1 0.7 2.8 0.3 -0.6 1.6 0.7 0.3 1.0 0.8 0.7 1.7 1.1 -0.9 -0.5 -0.4 0.9 -0.4 0.0 0.7
Length of working week for main job 0.9 1.0 3.2 -0.6 1.1 -0.4 0.1 0.5 0.2 1.6 -0.2 1.0 -0.4 1.8 1.6 -0.1 1.7 -1.5 -0.1 -0.3
Exposure to tobacco smoke at home 1.8 2.0 7.3 2.7 -0.7 1.7 1.0 0.6 -0.4 0.2 1.0 1.7 2.5 0.1 0.1 1.0 0.4 1.4 1.2 2.6
Breastfed as a baby 0.8 1.0 3.1 -0.3 1.4 -1.3 -0.6 -0.9 -1.1 -0.5 -0.7 0.2 0.7 1.8 1.6 0.6 1.1 -1.5 0.4 -0.1
Tense / ‘highly strung’ 1.2 2.0 7.8 0.7 0.1 2.2 2.1 1.5 2.8 1.1 2.4 1.6 -0.9 -0.5 -0.6 -0.1 1.4 -0.7 0.3 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 5.4 2.3 -0.2 1.9 2.0 1.2 0.7 1.1 2.1 2.0 -0.8 -0.4 0.1 1.2 2.3 1.2 1.4 1.7
Hair/balding pattern: Pattern 4 0.4 0.9 4.0 1.1 -1.2 2.0 1.0 0.5 0.1 0.6 1.1 0.9 0.4 -1.4 -0.9 0.5 0.3 -0.5 0.6 1.3
Birth weight of first child 0.4 0.8 3.7 -1.9 0.7 -1.7 -0.5 -0.6 0.4 -0.3 -0.6 -0.4 0.4 -0.6 0.2 -0.6 -1.0 -0.7 -0.6 -1.2
Peak expiratory flow (PEF) 0.4 1.0 3.5 -1.5 1.1 -1.9 -0.9 -1.0 -0.7 -1.2 -1.1 0.1 -0.6 0.6 0.8 -0.1 -0.9 0.2 -0.7 -1.3
Pulse wave reflection index 1.2 1.5 4.6 -1.2 1.2 0.3 1.7 1.6 2.0 0.6 1.4 1.9 0.3 0.7 0.9 -0.4 0.8 2.1 0.0 -0.3
Ever highly irritable/argumentative for 2 days 1.1 1.3 7.1 -1.2 1.1 1.0 0.9 1.3 2.7 1.1 1.1 0.8 0.7 0.7 0.7 -1.5 0.5 -0.9 -0.9 0.2
Loud music exposure frequency 0.3 0.3 1.4 0.4 0.5 -0.2 -0.1 -0.4 -1.2 -1.0 -0.1 -1.0 -0.1 0.3 0.3 1.1 -0.2 -0.2 0.3 -0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 3.8 -0.6 1.7 -1.3 0.6 0.3 -0.2 -0.1 0.5 0.3 -0.7 1.5 1.9 0.7 1.1 0.2 0.6 0.0
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 12.0 -0.7 -0.7 1.1 0.6 0.9 3.5 0.4 0.9 1.8 1.5 -0.9 -0.5 -2.4 0.0 0.9 -1.5 0.2
Blood clot in the leg (DVT) 0.6 0.8 4.0 2.0 -1.3 1.1 0.3 -0.1 0.1 0.3 0.6 0.9 0.5 -1.3 -1.0 0.4 0.1 1.1 0.5 0.6
Medication: Paracetamol 0.4 0.6 1.5 0.7 0.6 0.5 0.6 1.0 -0.9 1.2 0.6 -0.5 -0.7 0.0 0.3 1.2 0.6 1.2 1.0 0.6
Headache pain in last month 0.4 0.7 2.0 -0.3 0.5 -0.6 -0.5 -0.3 1.2 -1.1 -0.6 1.4 0.6 -0.3 -0.4 -1.3 -0.8 0.5 -1.4 -0.5
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.3 -1.8 0.7 -1.2 -0.3 -0.3 0.8 -1.1 -0.4 0.1 -0.3 0.4 0.3 -1.0 -0.5 1.4 -1.3 -1.6
Glaucoma (self-reported) 1.7 2.0 6.5 0.1 -1.4 -1.2 -2.4 -2.0 -0.6 -1.5 -2.5 -1.8 1.1 -0.5 -0.8 -1.3 -1.6 -0.3 -1.4 0.2
Gout (self-reported) 0.3 0.4 1.3 -0.2 0.5 -0.6 0.6 0.1 0.4 -0.4 0.4 0.7 0.5 0.9 1.0 0.3 1.1 0.5 0.4 0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 2.7 0.3 -0.2 -0.7 -0.8 -1.3 -0.7 -1.6 -0.6 -0.8 -0.1 0.1 0.3 0.4 -0.9 -0.3 -0.2 -0.5
Medication: Amlodipine 0.3 0.5 3.2 -1.0 0.7 -0.4 -0.3 0.0 0.1 -0.3 -0.5 0.2 1.1 0.8 0.5 -0.5 0.5 -1.8 -0.3 -0.2
Medication: Ventolin 100micrograms inhaler 1.2 1.5 4.0 -0.1 -1.5 -1.5 -1.2 -1.7 0.5 -1.7 -1.0 0.3 1.2 -1.1 -1.7 -0.7 -1.0 -1.0 -1.1 -2.0
Birth weight 0.3 0.6 1.8 -0.1 -0.2 -1.1 -1.0 -1.2 -1.1 -0.3 -0.9 -0.8 0.1 0.1 -0.5 0.4 -0.2 -1.1 0.1 -1.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.5 0.1 0.3 0.4 0.7 0.7 -0.5 -0.1 0.7 0.3 0.8 0.1 0.1 0.9 1.2 -0.4 0.9 0.6
High blood pressure (siblings) 2.9 4.1 11.7 3.4 0.0 2.8 1.7 1.6 -1.9 1.6 1.9 1.7 -1.1 0.2 0.5 3.0 1.8 1.1 3.1 2.8
Forced vital capacity (FVC), Best measure 0.3 1.0 3.5 -0.8 1.0 0.7 1.3 1.5 1.3 1.9 1.2 1.0 0.6 0.4 0.8 -0.5 0.4 1.7 0.0 0.4
Body fat percentage 0.1 0.4 2.2 0.2 -0.2 0.3 -0.2 -0.0 -0.9 -0.5 -0.4 1.4 1.0 -0.3 0.1 0.2 -1.5 0.3 0.0 0.6
Leg fat percentage (right) 0.1 0.3 1.7 0.2 -0.3 0.1 -0.4 -0.0 -0.2 -0.5 -0.6 0.9 1.3 -0.3 -0.1 -0.4 -1.3 -0.2 -0.5 0.6
Arm fat-free mass (right) 0.4 2.0 6.0 -1.3 0.1 -1.3 -1.8 -1.0 1.0 -0.7 -2.0 0.6 2.5 0.2 0.0 -2.4 -1.4 0.6 -2.3 -0.8
Exposure to tobacco smoke outside home 1.7 2.3 8.6 0.2 -2.4 0.6 0.1 -0.3 2.4 -0.5 0.3 1.4 2.2 -2.9 -2.2 -1.5 -1.3 0.6 -1.1 -0.4
Comparative body size at age 10 0.8 2.2 7.6 -1.5 0.3 -2.8 -2.2 -1.7 -1.0 -2.1 -2.4 0.2 0.3 1.1 0.4 -0.7 -1.7 -0.9 -1.3 -1.3
Number of full brothers 1.6 2.0 8.7 1.5 1.0 1.7 1.1 1.9 0.8 1.3 1.2 1.5 -0.6 0.4 1.0 0.2 1.0 2.9 0.9 2.2
Worry too long after embarrassment 0.9 1.6 6.1 2.5 0.2 1.6 1.4 1.1 0.2 0.4 1.6 0.8 -1.8 -0.5 -0.1 1.3 1.0 0.7 1.7 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 5.9 0.9 1.1 -0.0 1.2 0.9 -0.5 0.1 1.1 1.5 -1.2 0.9 1.1 1.7 1.6 2.4 1.5 0.5
Wheeze or whistling in the chest in last year 1.3 2.2 5.6 -1.4 -1.0 -1.6 -1.7 -1.4 0.4 -0.6 -1.5 -0.8 -0.4 -1.7 -1.9 -1.6 -1.7 -1.7 -1.8 -2.4
Number of children fathered 0.7 0.8 2.9 -1.5 0.1 -0.7 -0.6 0.4 -0.1 1.5 -0.7 -1.7 -0.8 -0.3 -0.1 -0.9 -0.8 -0.2 -0.7 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.2 -1.0 1.4 -1.1 -0.0 -0.2 -1.1 -0.2 -0.1 -0.4 -2.0 1.9 1.4 0.6 0.6 -0.3 0.3 -0.6
Age at first live birth 0.5 0.9 3.6 -1.2 1.8 -1.1 0.2 0.5 0.2 0.0 -0.1 -1.3 -0.5 1.9 1.5 -0.2 0.5 0.7 -0.1 0.2
Pulse wave peak to peak time 1.3 1.6 4.1 1.9 -1.8 -0.1 -1.3 -2.0 -1.5 -0.6 -1.0 -1.4 0.1 -1.4 -1.4 0.4 -0.8 -1.7 -0.2 -0.5
Health satisfaction 0.7 0.9 2.2 -0.5 1.3 -0.3 1.1 1.2 1.3 -0.2 1.1 1.2 1.5 1.2 1.1 0.2 0.6 0.6 0.2 0.5
Shortness of breath walking on level ground 0.8 1.0 3.9 -0.6 0.2 -0.1 1.4 1.1 1.9 0.4 1.4 2.0 0.5 -0.1 0.6 -0.7 0.5 1.6 -0.2 -0.1
Qualifications: College or University degree 0.6 2.0 7.0 -0.6 1.8 -2.6 -0.1 -0.8 -1.6 -2.1 -0.5 -1.1 -1.9 2.0 1.7 1.3 0.6 0.2 0.6 -0.8
Eye problems/disorders: None of the above 0.3 0.4 2.0 0.3 0.3 -0.6 -0.0 -0.3 -1.4 -0.0 -0.1 -0.5 -0.6 0.6 0.8 1.1 0.6 0.2 0.7 -0.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 4.1 -1.8 1.8 -0.3 0.9 1.6 1.1 0.8 0.8 0.3 -0.1 1.6 2.0 -0.6 0.3 1.3 0.0 0.3
Emphysema/chronic bronchitis 0.8 0.9 1.8 0.2 1.2 0.6 1.0 0.9 0.0 1.3 1.0 1.3 -1.3 1.0 0.9 0.7 1.3 0.4 0.9 0.3
Medication for pain relief, constipation, heartburn 0.5 0.8 2.8 -0.1 -1.2 -0.4 -0.4 -1.3 1.0 -1.2 -0.3 0.4 0.5 -1.0 -1.2 -0.7 -0.1 -0.7 -0.8 -1.7
Neck or shoulder pain in last month 0.3 0.4 1.7 -1.3 -0.1 -0.5 0.0 0.2 0.5 0.3 0.0 -0.7 1.1 0.1 0.2 -0.6 -1.0 0.7 -0.6 -0.9
Medication: Blood pressure 0.6 1.1 3.6 1.0 0.2 1.6 1.0 1.4 -0.1 1.8 1.0 0.8 0.9 0.0 0.3 0.5 1.3 -0.2 1.2 1.9
Angina (self-reported) 1.1 1.4 3.0 0.1 1.1 1.6 1.5 1.4 0.2 1.1 1.6 0.5 -0.7 0.8 1.4 0.8 1.5 -1.5 1.2 1.7
Migraine (self-reported) 0.5 0.6 3.0 1.1 -0.4 -0.1 -0.6 -0.7 -1.5 -0.5 -0.7 -0.0 -0.6 -0.2 0.1 0.7 0.5 -0.7 0.7 1.7
Medication: Ibuprofen 0.3 0.4 1.9 -0.7 0.6 0.5 -0.1 0.4 0.6 0.6 -0.2 -0.4 0.5 0.5 1.1 -0.5 -0.4 0.1 -0.3 1.4
Medication: Allopurinol 0.4 0.5 2.9 -0.3 -0.6 -0.6 -1.0 -1.2 -0.1 -0.9 -1.0 -0.5 0.3 -0.1 -0.5 -0.3 0.1 -1.7 -0.4 -0.4
Medication: Omeprazole 0.5 0.6 2.4 1.6 -0.6 0.8 -0.0 -0.4 -1.4 -0.3 0.1 -0.2 -0.8 -0.2 -0.2 1.4 -0.7 -0.3 0.8 0.6
Medication: Seretide 50 evohaler 0.8 0.9 3.2 0.5 -1.6 -0.3 -0.7 -1.7 -0.8 -1.1 -0.6 0.2 0.5 -1.8 -1.3 0.1 -0.7 -0.6 -0.4 -0.9
Mean time to correctly identify matches 0.6 1.2 5.1 2.2 -1.4 1.9 0.3 -0.1 -0.4 0.8 0.7 0.4 0.8 -0.9 -1.6 0.8 -1.3 -0.6 0.8 0.1
Heart disease (mother) 0.6 0.7 3.1 -0.1 0.4 1.2 0.6 1.0 0.7 1.1 0.6 0.1 0.6 0.1 0.4 -0.5 0.9 -1.6 0.1 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 4.0 -1.7 0.9 -0.6 0.8 1.2 -0.6 0.9 0.7 0.8 -2.0 0.4 0.5 0.8 0.3 0.1 0.9 -0.1
Whole body fat mass 0.2 0.8 3.9 -0.5 -0.2 -0.4 -1.1 -0.6 -0.4 -0.6 -1.3 1.2 1.7 -0.3 -0.1 -0.8 -2.0 0.0 -0.9 -0.1
Leg fat mass (right) 0.3 1.1 4.2 -0.4 -0.4 -0.4 -1.3 -0.7 0.4 -0.7 -1.4 1.1 2.0 -0.7 -0.5 -1.4 -2.1 -0.3 -1.5 -0.1
Arm predicted mass (right) 0.4 2.0 6.2 -1.3 -0.0 -1.3 -1.8 -1.0 1.1 -0.5 -2.0 0.7 2.5 0.2 -0.1 -2.4 -1.5 0.4 -2.2 -0.9
Pulse rate, automated reading 0.1 0.4 2.0 0.2 -0.1 0.6 -0.8 0.1 -0.0 0.0 -0.6 -0.3 -1.4 0.1 -0.4 -0.5 -1.3 0.8 -0.4 -0.2
Alcohol intake frequency. 0.3 0.8 2.9 -1.1 0.9 -0.7 0.2 0.7 0.0 0.5 -0.0 0.4 0.9 1.6 1.7 0.0 -0.3 1.1 0.3 1.3
Comparative height size at age 10 0.6 3.5 7.2 0.3 1.6 2.0 2.6 2.4 0.6 1.9 2.5 2.7 -1.2 1.4 2.1 1.3 2.5 1.1 1.7 1.8
Number of full sisters 0.5 0.7 2.6 -1.3 0.5 -0.6 -0.0 0.4 1.2 0.7 0.0 -0.0 1.6 0.1 0.0 -1.1 -1.4 0.5 -0.9 -0.6
Suffer from ‘nerves’ 0.7 1.1 3.8 1.3 -0.5 1.9 0.8 0.7 1.9 0.4 1.1 0.7 0.5 -1.1 -1.1 -0.6 1.0 0.9 -0.3 0.9
Overall health rating 0.6 1.2 4.4 1.4 -1.9 1.4 0.2 -0.2 0.4 0.4 0.4 1.3 1.5 -2.1 -1.9 0.2 -0.5 -0.4 0.4 0.6
Chest pain or discomfort 0.5 0.7 2.0 1.4 -1.1 0.9 0.7 0.4 0.7 0.8 0.9 1.3 0.2 -1.4 -1.4 0.3 0.3 -0.4 0.5 0.3
Had major operations 0.9 1.1 3.2 0.8 -1.5 -0.4 -0.9 -1.3 -0.2 -1.2 -0.7 -0.9 0.6 -1.5 -1.8 0.1 -1.3 -0.1 -0.3 -1.4
Age at last live birth 0.3 0.4 1.5 0.7 -0.1 1.2 0.6 0.4 1.1 0.5 0.7 0.0 -0.0 0.2 0.0 -0.7 0.2 1.0 -0.3 0.7
Family relationship satisfaction 1.5 1.8 6.2 -0.5 0.0 -2.0 -1.9 -1.7 0.5 -1.3 -1.9 -2.5 1.3 -0.0 0.0 -1.4 -0.7 1.1 -1.5 -1.0
Leg pain on walking 0.6 0.7 1.7 -1.3 0.8 -1.3 -1.0 -0.2 0.3 -0.7 -1.1 -0.4 0.5 0.9 0.8 -1.1 -0.7 1.2 -1.0 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.6 -0.4 0.1 -0.0 -0.8 -0.2 -0.1 0.1 -0.7 -0.1 0.2 0.1 0.2 -0.2 -0.3 -1.3 -0.4 -0.0
Commuting to job workplace: Car/motor vehicle 3.9 4.4 9.7 -1.8 -0.6 -2.0 -3.1 -2.4 0.6 -2.0 -3.1 -2.1 1.0 -0.9 -1.3 -2.5 -2.9 -1.2 -2.8 -2.5
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.4 -1.6 0.3 -1.7 -1.5 -1.4 -1.0 -0.8 -1.7 -1.8 -0.4 0.1 -0.6 -0.5 -1.3 -1.7 -1.0 -2.1
Medication: Aspirin 0.6 0.8 2.4 -1.5 1.5 -0.7 -0.0 0.9 0.6 -0.0 -0.2 0.2 0.7 1.5 1.1 -1.1 -0.6 0.7 -0.7 0.1
Supplements: Vitamin C 1.0 1.2 2.3 -0.3 1.3 -0.4 1.1 1.0 -0.6 0.7 0.9 1.1 -1.2 1.2 1.5 1.3 1.1 -1.0 1.5 1.3
Knee pain experienced in last month 1.1 1.7 3.9 -2.0 0.6 -2.0 -1.6 -0.9 -0.4 -0.9 -1.8 -1.1 -0.6 0.4 0.0 -1.2 -1.7 0.4 -1.6 -1.9
Hypertension (Self-reported) 0.2 0.4 1.0 0.6 0.6 0.6 -0.1 0.5 -1.0 1.0 -0.1 0.0 -0.6 0.8 0.7 0.5 0.5 -0.5 0.7 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 5.0 2.2 -0.9 1.6 -0.2 -0.1 -1.3 0.1 -0.1 -0.8 0.1 -1.3 -1.0 1.0 -0.9 0.9 0.9 0.9
Illnesses of father: Heart disease 0.7 1.0 4.6 1.8 -2.1 0.7 -0.5 -1.2 -0.3 -0.6 -0.3 0.2 0.7 -1.5 -1.5 -0.1 -0.0 -1.1 -0.3 -0.1
Illnesses of siblings: Diabetes 0.4 0.5 2.1 -1.0 0.1 -1.0 -0.5 -0.6 0.6 -0.5 -0.4 -0.1 0.3 0.4 -0.4 -0.4 -1.1 -1.4 -0.5 -0.8
Smoking status: Previous 0.8 1.2 4.4 0.7 -1.3 0.7 -0.9 -0.5 -0.6 0.8 -0.7 -0.7 -1.5 -1.6 -1.9 0.2 -0.8 -2.1 -0.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 2.1 0.3 0.8 0.1 -0.1 0.6 -0.4 1.5 -0.1 -0.5 0.3 0.6 0.7 0.6 0.7 0.6 0.4 0.8
Whole body fat-free mass 0.4 2.3 5.6 -1.8 0.2 -1.8 -1.8 -1.4 1.1 -1.1 -2.0 0.8 2.3 0.0 -0.1 -2.3 -1.6 0.5 -2.4 -1.5
Leg fat-free mass (right) 0.6 3.0 6.1 -2.0 0.3 -2.3 -2.2 -1.7 0.6 -1.3 -2.5 0.6 2.1 0.2 0.0 -2.3 -2.3 0.9 -2.5 -1.7
Arm fat percentage (left) 0.3 1.0 4.4 -0.2 -0.4 -0.9 -1.2 -1.1 -0.8 -1.5 -1.3 0.7 1.5 -0.5 -0.2 -0.5 -2.1 0.7 -0.9 -0.5
Average weekly red wine intake 0.3 0.5 1.6 0.3 -0.0 -0.5 0.5 -0.2 -1.2 -0.9 0.2 0.0 -0.4 0.8 0.7 1.2 0.9 0.7 0.9 0.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.2 0.3 0.0 0.2 1.3 0.9 -0.5 1.1 1.2 1.5 -0.2 -0.2 -0.3 1.2 0.4 0.4 1.3 0.5
Mood swings 1.2 2.2 6.2 1.5 -0.6 2.5 1.7 1.8 2.3 1.9 2.1 2.1 0.6 -0.5 -0.4 -0.0 1.0 1.3 0.5 1.4
Loneliness, isolation 0.4 0.6 3.6 0.4 -0.4 0.8 -0.1 -0.3 1.9 -0.9 0.2 0.6 0.6 -0.5 -0.4 -1.4 -0.4 0.6 -1.2 0.2
Long-standing illness, disability or infirmity 0.4 0.6 1.8 1.2 -0.3 0.7 0.5 0.5 -0.7 0.8 0.5 1.0 1.0 0.3 -0.1 1.3 -0.5 0.5 1.3 0.9
Ever had bowel cancer screening 1.4 1.6 4.2 1.6 -1.3 1.8 0.8 0.3 -1.3 1.0 1.0 0.4 -1.2 -1.3 -0.8 2.0 0.2 -1.5 2.0 1.1
Diabetes diagnosed by doctor 0.6 0.9 4.8 -1.2 -0.5 -0.4 -0.8 -0.2 0.5 0.2 -0.7 -0.1 0.9 -0.4 -1.0 -1.1 -1.7 -2.2 -1.0 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.2 0.6 -1.8 -0.5 -1.0 -1.4 0.1 -1.5 -0.9 -0.8 0.5 -1.4 -1.5 -0.5 -1.0 -0.6 -0.8 -1.1
Friendships satisfaction 0.2 0.2 0.6 0.7 0.5 -0.2 -0.0 -0.2 -0.2 -0.3 0.1 0.6 0.0 0.5 0.5 0.6 0.8 0.6 0.2 0.1
Qualifications: nursing, teaching 1.2 1.8 6.1 -1.1 1.7 -2.5 -0.4 -0.5 -2.3 -1.2 -0.7 -1.2 -0.2 2.5 1.9 1.4 0.4 -0.1 0.7 -0.0
Commuting to job workplace: Walk 1.6 1.7 8.1 -0.7 0.6 0.7 1.7 1.5 2.0 1.4 1.8 1.9 -0.4 0.4 0.3 -0.4 2.9 0.7 0.0 -0.7
Eye problems/disorders: Cataract 0.6 0.7 2.8 0.8 -1.1 0.3 -0.4 -0.6 0.9 -0.4 -0.3 -0.8 1.3 -1.5 -1.7 -0.7 -0.4 -0.8 -0.7 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 5.9 2.4 -1.8 2.0 0.9 0.1 -0.8 1.4 1.3 1.6 -2.3 -1.9 -1.4 2.0 0.8 -0.4 1.9 0.3
Medication for cholesterol 0.1 0.2 0.7 0.3 -0.2 0.4 0.3 0.1 0.8 0.5 0.2 0.8 -0.1 -0.6 -0.4 -0.2 0.4 0.5 -0.0 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.9 -1.4 0.8 -1.3 -0.5 -0.4 -0.1 -0.6 -0.6 -1.4 0.8 0.4 0.7 -0.5 -1.0 -0.5 -0.7 -0.4
Back pain experienced in last month 1.5 2.1 6.6 0.5 -2.0 -0.5 -1.8 -1.5 0.0 -0.6 -1.7 -1.8 2.6 -1.6 -1.6 -1.3 -1.9 -0.3 -1.3 -0.8
Mineral and other dietary supplements 2.6 3.5 8.4 1.0 -2.6 0.7 -2.0 -1.9 1.5 -1.7 -1.6 -1.1 1.9 -2.6 -2.9 -2.5 -1.2 -0.9 -2.6 -0.7
Breast cancer (self-reported) 1.8 2.2 5.2 0.3 1.9 1.4 1.7 2.1 1.1 1.4 1.5 0.3 -0.4 1.8 2.0 0.8 2.3 0.3 1.2 2.0
Asthma (self-reported) 0.8 1.6 4.0 -1.0 -0.6 -1.1 -1.7 -1.3 0.8 -1.0 -1.5 -0.6 0.5 -1.1 -0.8 -1.5 -2.0 -0.5 -1.8 -1.8
Osteoporosis (self-reported) 1.4 1.7 5.9 -0.4 1.6 0.2 1.1 1.4 0.7 1.2 0.9 0.9 0.2 2.4 2.3 0.4 1.8 1.5 0.8 1.2
Osteoarthritis (self-reported) 0.5 0.7 2.4 -1.5 1.4 0.1 0.4 1.2 -0.2 1.1 0.3 0.6 -0.5 1.0 1.1 0.3 -0.7 -0.6 0.5 0.8
Medication: Aspirin 0.8 1.0 3.3 -1.6 1.7 -0.8 -0.0 0.9 1.0 -0.3 -0.2 0.0 1.1 1.8 1.1 -1.3 -0.5 0.9 -0.9 0.1
Medication: Gliclazide 1.1 1.2 2.9 -1.2 0.3 -0.8 -1.3 -1.2 0.8 -0.8 -1.3 -1.4 1.3 0.3 0.0 -1.4 -0.9 -1.2 -1.7 -1.0
Illnesses of father: None of the above (group 1) 0.3 0.4 1.8 -1.1 1.3 -0.2 0.1 0.8 -0.3 0.7 0.1 -0.2 -1.0 0.8 0.8 0.2 0.3 0.0 0.1 0.1
Smoking status: Current 0.3 0.4 1.9 0.4 -0.2 0.1 -0.3 -0.5 1.2 -0.4 -0.1 0.2 -0.6 -0.7 -0.4 -1.4 0.9 0.0 -1.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.2 6.5 -1.1 2.6 0.3 1.7 1.8 -0.4 1.0 1.4 0.1 -1.4 2.2 2.4 1.1 1.7 1.7 1.2 0.7
Whole body water mass 0.4 2.3 5.8 -1.7 0.2 -1.7 -1.8 -1.3 1.2 -1.1 -1.9 0.9 2.4 0.1 -0.1 -2.4 -1.6 0.4 -2.4 -1.4
Leg predicted mass (right) 0.5 2.9 5.8 -2.0 0.2 -2.2 -2.2 -1.7 0.7 -1.3 -2.4 0.7 2.0 0.1 -0.0 -2.3 -2.3 0.9 -2.4 -1.6
Arm fat mass (left) 0.5 2.1 7.5 -0.6 -0.6 -1.2 -2.0 -1.6 -0.3 -1.6 -2.1 0.6 1.9 -0.7 -0.7 -1.5 -2.7 0.3 -1.9 -1.0
Number of self-reported non-cancer illnesses 0.4 0.7 2.5 1.6 0.4 1.4 0.2 0.7 -0.5 1.0 0.4 1.2 -0.1 0.1 0.1 0.9 0.1 -0.4 0.9 1.5
Average weekly champagne plus white wine intake 0.2 0.3 1.1 -0.4 0.2 0.3 0.5 0.4 1.0 0.3 0.6 0.9 0.3 -0.1 -0.2 -0.6 0.7 -0.3 -0.4 -0.7
Miserableness 1.6 2.7 9.0 1.8 -2.4 2.0 0.6 -0.2 2.9 0.6 1.3 1.4 1.7 -3.0 -2.4 -1.2 0.2 -1.2 -0.5 0.3
Guilty feelings 0.3 0.4 2.1 1.3 -0.6 1.0 0.5 0.1 0.2 0.1 0.7 1.5 0.4 -0.6 -0.4 0.4 0.1 0.6 0.4 0.4
Wears glasses or contact lenses 0.8 0.9 3.0 -1.0 0.4 -1.2 -1.0 -0.8 0.1 -1.1 -1.1 -1.2 -0.7 0.6 0.1 -0.7 -1.7 -1.0 -0.9 -1.3
Ever taken oral contraceptive pill 1.3 1.5 3.4 -0.2 -1.3 -1.0 -1.8 -1.6 0.1 -1.6 -1.7 -1.2 -0.4 -1.3 -1.0 -1.3 -1.2 -0.2 -1.5 -1.2
Hearing aid user 1.1 1.2 4.8 1.4 -1.4 1.2 0.5 -0.2 0.4 0.6 0.7 0.4 -0.8 -2.0 -1.9 0.2 0.0 -2.2 0.3 0.2
Mother’s age at death 1.1 1.4 2.9 -0.0 1.1 0.4 1.6 1.5 -0.8 0.1 1.4 0.2 -0.5 1.4 1.6 1.3 0.7 1.5 1.7 1.7
Financial situation satisfaction 1.2 1.4 7.1 0.6 -1.0 0.3 -0.2 -0.7 2.2 -1.1 0.2 0.7 2.7 -1.4 -1.3 -1.4 -0.4 1.0 -1.2 -0.9
Tinnitus: Yes, now most or all of the time 0.9 1.0 3.5 -0.7 -1.4 0.6 0.2 -0.2 1.1 0.1 0.4 -0.5 -0.6 -1.6 -1.5 -0.6 0.0 -1.7 -0.9 -1.9
Commuting to job workplace: Public transport 4.9 5.8 12.5 0.4 2.0 1.7 3.5 3.2 0.0 2.4 3.5 3.0 -0.8 2.1 2.4 2.2 2.7 2.2 2.7 2.5
Eye problems/disorders: Glaucoma 1.0 1.2 3.0 -1.1 -0.3 -1.4 -1.5 -1.1 0.6 -0.9 -1.7 -0.9 1.2 -0.0 -0.2 -1.6 -1.2 -0.2 -1.6 -0.6
Medication: Blood pressure 0.7 1.3 3.7 0.1 1.3 0.4 0.8 1.1 -1.4 0.3 0.7 -0.1 -0.9 1.9 1.7 1.5 0.7 -0.1 1.6 1.7
Pain type(s) experienced in last month: Hip pain 0.8 1.1 3.8 1.1 0.5 0.3 0.4 0.5 -1.8 0.5 0.4 1.1 -1.9 0.6 1.1 1.4 0.5 1.2 1.3 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.8 6.2 0.4 1.1 -0.4 1.0 0.7 -2.0 1.4 0.9 0.5 -2.3 1.1 1.3 2.5 1.0 -0.1 2.2 0.1
High cholesterol (Self-reported) 0.4 0.7 1.8 1.0 -0.9 1.4 1.0 0.8 0.2 1.0 1.3 0.8 0.1 -0.6 -0.6 0.8 0.1 -0.6 1.0 0.6
Medication: Bendroflumethiazide 0.8 1.2 3.7 0.4 1.6 -0.3 -0.0 0.7 -1.3 0.5 -0.2 -1.5 -1.3 1.9 1.6 0.7 1.4 0.3 0.9 1.4
Medication: Paracetamol 0.1 0.1 0.7 0.5 0.2 0.3 -0.1 0.2 -0.3 0.6 -0.1 -0.6 0.3 -0.4 -0.3 0.3 -0.3 0.9 0.1 0.2
Medication: Lisinopril 0.8 1.0 3.7 0.0 0.3 0.8 1.4 1.3 1.9 1.1 1.4 0.1 0.7 0.1 0.2 -0.8 1.5 1.5 0.0 0.8
Medication: Atorvastatin 3.7 4.5 13.0 3.0 -2.2 3.6 2.0 1.2 -0.3 2.8 2.4 1.8 -1.2 -2.4 -1.8 2.1 1.9 -0.8 2.4 1.3
Illnesses of father: High blood pressure 1.6 1.9 9.9 -0.7 2.5 -1.3 0.3 0.6 -0.3 -0.3 -0.1 -0.6 0.6 3.1 3.0 0.3 0.6 1.7 0.4 0.5
Alcohol drinker status: Never 1.0 1.2 3.9 -1.8 0.7 -1.3 -0.8 -0.2 0.5 -0.6 -1.0 0.5 0.6 1.2 0.9 -1.1 -2.0 1.6 -1.2 -0.7
Ever smoked 0.6 1.0 4.5 1.1 -0.8 1.1 0.3 0.2 -0.4 1.3 0.4 0.0 -2.1 -1.3 -1.0 0.8 0.7 -1.6 0.5 -0.5
Basal metabolic rate 0.4 2.4 6.0 -1.5 -0.1 -1.6 -1.9 -1.5 1.0 -1.2 -2.1 0.9 2.4 -0.2 -0.3 -2.3 -1.9 0.5 -2.4 -1.4
Leg fat percentage (left) 0.1 0.5 2.9 0.1 -0.3 0.0 -0.6 -0.1 -0.1 -0.5 -0.7 1.2 1.2 -0.4 -0.3 -0.6 -1.7 -0.3 -0.6 0.3
Arm fat-free mass (left) 0.3 1.5 4.4 -1.2 0.4 -1.1 -1.4 -0.7 1.1 -0.7 -1.6 1.1 2.1 0.4 0.2 -2.1 -1.2 0.5 -1.9 -0.7
Number of operations (self-reported) 0.3 0.4 1.9 0.7 -1.4 0.4 0.1 -0.4 0.1 -0.1 0.2 -0.5 -0.5 -1.2 -1.3 0.6 -0.1 -0.7 0.4 -0.3
Average weekly beer plus cider intake 0.9 1.2 3.7 0.3 -0.9 -0.5 -1.7 -1.0 -0.1 -1.1 -1.6 -0.7 1.9 -0.5 -0.7 -1.1 -1.9 0.8 -1.4 0.2
Irritability 0.8 1.3 4.7 1.4 0.1 2.1 1.1 1.6 0.2 2.2 1.3 0.4 0.2 -0.1 -0.2 1.1 0.2 -0.0 1.4 1.7
Risk taking 0.3 0.5 3.3 -0.9 0.4 -0.4 0.5 0.7 -0.3 0.9 0.4 -0.8 -1.8 0.1 0.4 0.4 0.4 0.5 0.5 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.3 -0.4 0.5 -1.1 0.3 -0.5 -0.5 -1.0 0.2 -0.6 -0.9 -0.5 0.2 0.8 0.1 -1.1 0.5 -1.1
Fractured/broken bones in last 5 years 0.9 1.2 4.2 -1.7 0.6 -0.8 -0.3 -0.2 1.8 -0.3 -0.4 0.6 0.5 0.3 0.1 -2.0 0.2 0.5 -1.7 -2.1
Age started oral contraceptive pill 0.2 0.3 1.0 -0.8 0.9 -0.4 0.3 -0.0 -0.1 -0.9 0.2 -0.2 0.7 1.0 0.8 -0.1 0.5 -0.2 -0.1 0.1
Diastolic blood pressure, automated reading 0.4 1.2 4.9 -1.6 2.2 -1.3 -0.4 0.6 0.4 -0.5 -0.7 0.1 -0.6 2.0 1.8 -0.9 -0.5 0.5 -0.8 -0.3
Ever depressed for a whole week 3.3 4.1 13.4 -1.2 3.0 -0.2 2.9 2.5 2.1 1.0 2.7 1.4 -0.3 2.2 2.8 0.2 3.7 1.7 0.8 0.9
Unable to work because of sickness or disability 0.3 0.4 3.1 0.2 -0.0 -0.3 -0.4 -0.3 0.6 -0.7 -0.5 0.1 1.8 0.3 -0.0 -0.6 -0.1 1.2 -0.6 0.1
Commuting to job workplace: Cycle 1.1 1.4 5.1 0.1 1.2 -0.3 1.1 1.1 -1.3 1.2 0.9 0.8 -0.4 1.3 1.2 1.6 0.6 2.2 1.8 0.8
Myopia 0.3 0.4 1.0 -0.6 0.8 -0.9 0.2 -0.3 -0.5 -0.3 -0.0 -0.9 -0.8 0.9 0.8 0.7 0.6 -0.7 0.4 -1.0
Vascular/heart problems diagnosed by doctor 0.6 1.7 5.2 -0.3 -1.8 -0.0 -0.1 -0.8 2.2 -1.0 0.2 0.3 0.9 -2.3 -2.0 -1.5 -0.6 0.1 -1.6 -1.7
Cholesterol lowering medication 0.1 0.2 1.6 -0.5 -0.7 -0.0 -0.2 0.1 0.1 0.1 -0.2 -0.3 -0.1 -0.1 -0.5 -0.3 -1.3 -0.4 -0.3 -0.0
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 5.6 1.9 -1.1 0.4 -0.5 -1.0 -2.4 -0.8 -0.4 -1.0 -0.7 -0.4 -0.5 1.8 -1.2 -0.3 1.1 0.5
Pain experienced in last month 0.6 1.0 2.3 1.1 -0.8 1.1 1.3 0.3 0.1 0.7 1.4 1.0 -0.6 -0.6 -0.5 1.2 1.5 -1.2 1.3 0.3
Supplements: Calcium 1.0 1.1 3.6 0.3 0.9 0.6 1.1 1.0 -0.6 0.9 0.9 -0.5 -0.7 1.5 1.5 1.2 1.1 0.5 1.3 1.9
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 0.5 0.5 0.1 -0.0 -0.4 0.2 -0.6 0.1 0.5 -1.0 0.3 0.3 0.0 1.0 0.1 -0.0 -0.2
Heart attack/myocardial infarction (self-reported) 1.8 2.4 6.2 0.4 1.3 1.2 1.3 1.8 -2.1 1.9 1.1 -0.3 -0.3 1.7 1.3 2.2 0.2 -1.2 2.4 2.5
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.6 1.9 -1.4 1.1 0.4 0.0 0.2 0.3 0.7 1.3 0.5 -1.3 -1.0 0.3 -0.0 1.3 0.6 0.6
Heart disease (siblings) 1.4 1.7 6.9 2.6 -1.1 1.8 0.8 0.2 -1.3 -0.0 0.9 0.7 0.5 -0.4 -0.7 2.0 -0.4 -0.7 1.9 2.1
Alcohol drinker status: Previous 3.4 3.8 9.7 2.1 -0.4 2.6 2.5 2.4 -0.2 3.1 2.7 1.3 -0.5 0.1 0.4 2.3 0.8 1.1 2.9 2.6
Pack years of smoking 1.8 2.6 6.4 -0.2 -1.8 -0.4 -2.5 -2.3 0.2 -1.3 -2.4 -1.1 0.5 -1.8 -1.9 -2.0 -1.1 -1.1 -2.3 -1.3
Impedance of whole body 0.9 4.5 11.4 2.4 -0.7 3.4 3.0 2.1 -0.5 1.9 3.2 0.7 -1.6 -0.8 -0.4 2.7 2.4 -0.6 2.9 2.3
Leg fat mass (left) 0.3 1.3 5.3 -0.5 -0.4 -0.5 -1.4 -0.8 0.4 -0.7 -1.5 1.3 1.9 -0.6 -0.6 -1.5 -2.3 -0.4 -1.6 -0.3
Arm predicted mass (left) 0.4 1.9 6.1 -1.5 0.5 -1.2 -1.5 -0.8 1.4 -0.7 -1.7 0.8 2.5 0.4 0.2 -2.4 -1.4 0.4 -2.2 -0.9