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chr14:22,670,975-26,218,651

Best TWAS P=1.91e-17 · Best GWAS P=3.49e-57 conditioned to 4.57e-39

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HAUS4	0.20	0.25	lasso	7	0.25	1.2e-29	-5.2	-5.4	5.1e-08	-0.02	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STXBP6	0.21	0.04	lasso	10	0.16	1.2e-19	6.5	-6.5	6.8e-11	-0.04	0.01	0.99	TRUE
3	GTEx	Adipose Visceral Omentum	HAUS4	0.29	0.17	lasso	14	0.21	5.2e-11	-5.4	-5.8	7.5e-09	0.02	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	HAUS4	0.35	0.22	enet	11	0.21	3.5e-08	-5.4	-5.7	9.9e-09	0.02	0.96	0.00	FALSE
5	GTEx	Artery Aorta	HAUS4	0.35	0.26	enet	14	0.32	6.1e-18	-5.2	-5.9	3.2e-09	0.00	1.00	0.00	FALSE
6	GTEx	Artery Aorta	RP11-298I3.1	0.18	0.07	enet	12	0.08	2.6e-05	-5.9	6.0	1.5e-09	0.00	0.89	0.00	FALSE
7	GTEx	Artery Coronary	HAUS4	0.36	0.25	lasso	5	0.22	8.6e-08	-6.3	-5.7	9.7e-09	0.00	0.98	0.00	FALSE
8	GTEx	Brain Cerebellum	HAUS4	0.36	0.27	enet	6	0.32	2.6e-10	-5.7	-6.2	6.4e-10	0.00	0.98	0.00	FALSE
9	GTEx	Brain Cerebellum	RBM23	0.31	0.18	lasso	4	0.22	3.4e-07	-5.7	5.5	3.7e-08	0.01	0.79	0.01	FALSE
10	GTEx	Brain Frontal Cortex BA9	HAUS4	0.26	0.07	lasso	6	0.04	3.7e-02	-5.7	-6.0	1.9e-09	0.00	0.16	0.05	FALSE
11	GTEx	Brain Putamen basal ganglia	HAUS4	0.29	0.00	enet	4	-0.01	6.3e-01	-5.7	-5.9	3.3e-09	0.00	0.12	0.07	FALSE
12	GTEx	Breast Mammary Tissue (Male)	HAUS4	0.30	0.12	lasso	11	0.10	2.6e-03	-5.2	-5.4	6.4e-08	-0.03	0.21	0.05	FALSE
13	GTEx	Colon Transverse	HAUS4	0.30	0.28	enet	8	0.27	3.2e-13	-5.4	-5.6	1.8e-08	-0.01	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	HAUS4	0.33	0.26	enet	17	0.28	7.4e-19	-5.9	-5.7	1.0e-08	0.00	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	STXBP6	0.31	0.15	lasso	12	0.15	2.6e-09	6.3	-6.4	1.5e-10	-0.02	1.00	0.00	TRUE
16	GTEx	Heart Left Ventricle	HAUS4	0.17	0.13	lasso	2	0.12	5.0e-07	-5.2	5.2	2.0e-07	0.04	0.75	0.01	FALSE
17	GTEx	Lung	HAUS4	0.30	0.26	enet	26	0.29	1.9e-22	-5.4	-5.6	1.7e-08	-0.01	1.00	0.00	FALSE
18	GTEx	Muscle Skeletal	HAUS4	0.09	0.08	lasso	4	0.06	1.4e-06	-5.7	-5.7	1.1e-08	-0.02	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	HAUS4	0.36	0.29	enet	38	0.33	8.2e-24	-5.4	-5.5	4.5e-08	-0.01	1.00	0.00	FALSE
20	GTEx	Ovary	HAUS4	0.32	0.10	enet	16	0.09	2.6e-03	-5.2	-5.4	7.7e-08	0.04	0.23	0.04	FALSE
21	GTEx	Pancreas	RBM23	0.20	0.10	enet	7	0.03	1.7e-02	-5.4	5.1	3.1e-07	0.00	0.27	0.04	FALSE
22	GTEx	Skin Sun Exposed Lower leg	HAUS4	0.31	0.25	enet	25	0.32	2.5e-27	-5.2	-5.5	3.1e-08	-0.02	1.00	0.00	FALSE
23	GTEx	Skin Sun Exposed Lower leg	AJUBA	0.12	0.04	lasso	4	0.05	6.8e-05	-6.3	6.1	9.7e-10	-0.05	0.78	0.02	FALSE
24	GTEx	Stomach	HAUS4	0.29	0.20	enet	13	0.20	6.0e-10	-5.4	-6.1	1.2e-09	0.00	1.00	0.00	FALSE
25	GTEx	Stomach	STXBP6	0.18	0.05	enet	6	0.04	4.1e-03	6.3	-5.8	5.3e-09	0.01	0.12	0.40	FALSE
26	GTEx	Stomach	RP11-298I3.1	0.29	0.16	lasso	9	0.14	2.4e-07	-5.9	6.6	3.2e-11	0.03	0.99	0.00	TRUE
27	GTEx	Vagina	HAUS4	0.37	0.18	enet	12	0.16	1.8e-04	-5.4	-5.5	3.6e-08	0.00	0.36	0.04	FALSE
28	METSIM	Adipose	AP1G2	0.05	0.04	bslmm	404	0.03	8.1e-05	4.2	5.3	1.2e-07	0.02	0.99	0.00	TRUE
29	METSIM	Adipose	SLC7A8	0.07	0.00	blup	492	0.02	4.2e-04	4.7	-8.5	1.9e-17	-0.39	0.04	0.58	TRUE
30	NTR	Blood	SLC7A8	0.09	0.00	bslmm	498	0.05	6.6e-17	1.4	-6.0	2.4e-09	-0.35	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HAUS4	0.09	0.04	lasso	5	0.04	5.1e-04	-5.4	-5.4	8.3e-08	-0.03	0.24	0.54	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS4	0.03	0.06	blup	41	0.06	1.1e-12	-5.4	-5.7	1.2e-08	0.00	0.05	0.95	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	HAUS4	0.21	0.23	blup	40	0.28	4.5e-09	-6.3	-6.4	2.1e-10	0.01	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS4	0.03	0.05	blup	41	0.04	8.4e-06	-5.1	-5.4	5.2e-08	0.00	0.12	0.87	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HAUS4	0.17	0.17	lasso	4	0.19	2.7e-11	-5.4	-5.4	6.9e-08	-0.05	0.17	0.83	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	HAUS4	0.11	0.20	lasso	7	0.22	5.5e-24	-5.1	-5.6	2.2e-08	-0.02	0.50	0.50	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HAUS4	0.09	0.07	blup	41	0.08	8.0e-06	-5.9	-5.9	3.1e-09	0.03	0.06	0.93	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS4	0.12	0.19	lasso	4	0.21	4.8e-09	-5.9	-5.9	4.1e-09	-0.03	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS4	0.12	0.15	lasso	4	0.15	1.3e-06	-5.4	-5.4	6.4e-08	-0.02	0.14	0.79	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS4	0.12	0.15	blup	40	0.19	1.2e-19	-6.3	-5.8	4.9e-09	0.05	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAUS4	0.07	0.06	blup	40	0.08	1.3e-05	-5.4	-5.8	6.8e-09	0.01	0.04	0.95	FALSE
42	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HAUS4	0.13	0.15	lasso	8	0.17	2.8e-05	-6.3	-6.0	2.1e-09	0.00	0.02	0.94	FALSE
43	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HAUS4	0.12	0.07	blup	39	0.10	3.0e-04	-5.1	-5.6	2.3e-08	0.01	0.05	0.87	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS4	0.15	0.22	lasso	5	0.23	2.4e-22	-5.4	-5.8	7.2e-09	-0.01	0.29	0.71	FALSE