TWAS hub - AP1G2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2780	0.0660	1.3e-04	0.212	NA	0.208	NA	0.207	6.9e-12	NA	1.1e-11	NA	1.3e-11
2	GTEx	Artery Tibial	0.2915	0.0560	9.8e-07	0.183	NA	0.151	NA	0.176	2.9e-14	NA	7.4e-12	NA	9.6e-14
3	GTEx	Colon Transverse	0.3900	0.0920	4.2e-04	0.031	NA	0.077	NA	0.094	1.3e-02	NA	1.6e-04	NA	3.3e-05
4	METSIM	Adipose	0.0545	0.0227	6.0e-03	0.040	0.003	0.020	0.026	0.025	9.8e-07	0.091	4.1e-04	8.1e-05	8.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Diabetes (father)	7.5	9.3	10.9	3.3	3.3	-2.8	2.8
Pack years of smoking	6.7	9.8	13.9	3.7	3.5	-1.7	3.2
Pack years adult smoking proportion	6.3	9.6	13.9	3.7	3.4	-1.6	3.2
Frequency of depressed mood in last 2 weeks	5.6	7.8	11.5	3.1	3.0	-1.0	3.4
Pulse rate	5.5	9.3	24.2	-1.8	-2.0	4.9	-2.4
Mouth/teeth dental problems: Bleeding gums	5.5	7.1	9.6	3.1	3.0	-0.7	3.1
Frequency of tenseness / restlessness in last 2 weeks	5.4	8.3	11.4	3.3	3.4	-1.4	3.1
Time employed in main current job	4.9	5.6	7.5	-2.3	-2.5	1.7	-2.7
Loneliness, isolation	4.2	5.8	8.5	2.6	2.6	-1.1	2.9
Depression (Nagel 2018)	4.1	6.2	8.9	2.4	2.5	-2.0	3.0
Qualifications: None of the above	4.1	8.9	9.6	3.1	3.1	-2.7	3.1
Qualifications: nursing, teaching	3.9	6.1	7.3	-2.6	-2.3	2.7	-2.2
Pulse wave reflection index	3.8	4.7	7.0	2.0	1.8	-2.6	2.1
Pulse rate, automated reading	3.8	12.4	44.4	-0.9	-1.1	6.7	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	6.7	2.0	2.2	-1.8	2.6
Mouth/teeth dental problems	3.5	5.4	7.9	-2.8	-2.8	0.1	-2.4
Qualifications: CSEs or equivalent	3.3	4.3	7.6	-1.9	-1.9	2.8	-1.7
Townsend deprivation index at recruitment	3.2	4.5	6.7	2.6	2.2	0.3	2.5
Mineral and other dietary supplements	3.1	4.2	6.2	-1.8	-1.9	2.5	-2.0
Medication: Lisinopril	3.0	3.8	5.2	-2.2	-2.3	0.2	-2.3
Taking other prescription medications	2.8	4.3	5.9	-2.4	-2.4	1.0	-2.2
Illnesses of father: Heart disease	2.8	3.9	6.0	-2.1	-2.2	0.1	-2.5
Supplements: Fish oil (including cod liver oil)	2.8	3.7	5.7	1.7	1.7	-2.4	1.9
Depression (self-reported)	2.7	3.3	5.6	2.1	1.8	-0.0	2.4
Chronic bronchitis/emphysema (father)	2.6	3.0	3.8	1.4	1.6	-1.9	1.9
Handedness (chirality/laterality): Left-handed	2.6	3.1	4.5	2.0	1.9	-0.6	2.1
Blood Eosinophil Count	2.4	18.5	28.0	4.1	4.3	-3.2	5.3
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	7.6	-1.4	-1.4	2.8	-0.9
Medication: Simvastatin	2.4	3.5	5.2	-1.7	-1.8	2.3	-1.7
Hayfever, allergic rhinitis or eczema	2.3	4.9	6.4	-2.5	-2.5	1.6	-2.1
Supplements: Calcium	2.3	2.6	4.6	1.5	1.6	-1.0	2.1
LDL Cholesterol	2.2	3.5	4.4	1.8	2.0	-2.1	1.6
Glaucoma (self-reported)	2.1	2.5	4.7	1.2	1.4	-2.2	1.4
Number of children fathered	2.1	2.3	3.4	1.3	1.5	-1.8	1.5
Depressed Affect (Nagel 2018)	2.0	4.2	6.3	2.4	2.1	-0.3	2.5
Prostate Cancer	2.0	2.8	4.5	-1.5	-1.5	1.6	-2.1
Severe depression (siblings)	2.0	2.3	2.4	1.6	1.6	-1.4	1.5
Breastfed as a baby	2.0	2.5	3.5	-1.8	-1.9	1.1	-1.4
Gout (self-reported)	2.0	2.8	3.6	-1.9	-1.9	1.0	-1.7
Age at First Birth	1.9	2.8	3.9	1.7	1.7	-1.2	2.0
Sensitivity / hurt feelings	1.8	3.0	4.2	1.9	2.0	-0.5	2.1
Hearing aid user	1.8	2.0	3.0	1.6	1.6	0.3	1.7
Neuroticism (2016)	1.7	2.4	3.9	2.0	1.7	-0.2	1.7
Supplements: Zinc	1.7	1.9	3.0	1.3	1.5	-0.8	1.7
Fed-up feelings	1.7	3.1	4.8	2.1	1.8	-0.3	2.2
Miserableness	1.7	3.0	4.6	2.2	1.8	0.3	2.0
Average weekly spirits intake	1.6	2.0	6.1	-0.9	-0.9	2.5	-0.6
Medication for hormone replacement therapy	1.6	1.8	2.2	1.5	1.1	-1.4	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.1	1.2	1.3	-1.8	1.1
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.4	-1.5	-1.7	-0.0	-1.9
Chest pain or discomfort	1.6	2.2	2.7	-1.5	-1.6	1.4	-1.4
Unable to work because of sickness or disability	1.6	2.0	3.5	1.6	1.4	-0.1	1.9
Systolic Blood Pressure	1.5	7.7	10.9	-3.1	-3.3	-0.3	-3.2
Exposure to tobacco smoke at home	1.5	1.7	2.3	1.5	1.5	0.6	1.4
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.3	1.5	1.5	-0.9	1.4
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.3	1.5	1.4	-0.5	1.4
Number of full brothers	1.4	1.8	2.3	1.4	1.1	-1.5	1.3
Illnesses of father: High blood pressure	1.4	1.8	2.6	-1.3	-1.1	1.6	-1.3
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.2	-1.4	-1.1	1.4	-1.5
HDL Cholesterol	1.3	2.1	2.2	-1.4	-1.5	1.4	-1.5
Vitamin and mineral supplements	1.3	1.8	4.5	-1.1	-1.0	2.1	-0.8
Diabetes (mother)	1.3	1.6	3.0	1.2	1.1	-1.7	1.0
Multivitamins +/- minerals	1.3	1.6	3.5	1.0	1.0	-1.9	1.0
Mood swings	1.3	2.4	3.4	1.8	1.6	0.6	1.8
Eye problems/disorders: Glaucoma	1.3	1.5	3.6	0.7	0.9	-1.9	1.1
Rheumatoid Arthritis	1.2	1.7	2.6	-1.1	-1.0	1.6	-1.3
Allergy	1.2	2.7	3.4	1.8	1.8	-1.3	1.6
Falls in the last year	1.2	1.6	2.4	1.4	1.4	-0.4	1.6
Migraine (self-reported)	1.2	1.5	1.9	-1.2	-1.4	1.3	-1.1
Irritable Bowel Disease (IBD)	1.1	2.5	2.9	-1.5	-1.6	1.7	-1.5
Maternal smoking around birth	1.1	1.6	2.6	1.2	1.2	1.6	0.9
Medication: Seretide 50 evohaler	1.1	1.3	1.8	-1.1	-1.1	1.4	-0.9
Crohns Disease (2017)	1.0	2.2	3.3	-1.4	-1.5	1.8	-1.1
Ulcerative Colitis (UC)	1.0	1.9	2.2	-1.2	-1.4	1.4	-1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.6	-1.0	-1.1	1.3	-1.1
Exposure to tobacco smoke outside home	1.0	1.3	1.9	1.4	1.3	0.5	1.3
Illnesses of siblings: Diabetes	1.0	1.2	1.5	-1.0	-1.1	1.2	-1.1
Mother’s age at death	1.0	1.2	2.3	-1.0	-1.2	-0.1	-1.5
Neuroticism (Nagel 2018)	0.9	2.0	3.1	1.8	1.5	-0.0	1.6
Coronary Artery Disease (CAD)	0.9	1.0	3.7	0.0	0.0	0.7	-1.9
Smoking Status	0.9	2.1	2.5	1.6	1.4	1.2	1.6
Diabetes (self-reported)	0.9	1.4	1.9	-1.1	-1.4	1.1	-1.2
Smoking status: Previous	0.9	1.4	2.0	1.3	1.3	-0.4	1.4
Osteoarthritis (self-reported)	0.9	1.1	1.9	-1.1	-1.4	0.4	-1.1
Medication: Blood pressure	0.9	1.7	2.5	-1.2	-1.6	1.3	-1.1
Medication: Atorvastatin	0.9	1.1	2.6	0.6	0.9	-1.6	0.8
Diastolic blood pressure, automated reading	0.9	2.7	3.3	-1.7	-1.4	1.8	-1.7
Blood Platelet Count	0.8	9.5	12.5	3.5	3.3	-1.9	3.3
High blood pressure (mother)	0.8	1.2	1.8	-1.1	-1.2	-0.3	-1.4
Had menopause	0.8	1.0	3.0	-0.5	-0.6	1.7	-0.6
Financial difficulties in last 2 years	0.8	1.0	2.6	-0.5	-0.8	1.6	-0.8
Heart attack	0.8	1.0	1.3	-1.1	-0.8	0.9	-1.1
Neuroticism score	0.8	1.7	2.6	1.6	1.3	0.2	1.6
Loud music exposure frequency	0.8	0.9	3.4	-0.3	-0.3	1.8	-0.2
Age at first live birth	0.8	1.4	4.4	-0.7	-0.6	2.1	-0.6
Comparative height size at age 10	0.8	4.3	6.1	2.4	2.3	0.0	2.5
Age at last live birth	0.8	1.2	4.2	-0.5	-0.5	2.1	-0.2
Leg fat percentage (left)	0.8	3.0	4.0	1.8	2.0	-1.5	1.6
Heart disease (siblings)	0.8	0.9	1.7	-1.1	-1.3	-0.0	-0.9
Alcohol drinker status: Previous	0.8	1.0	1.4	0.9	1.0	-0.8	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.7	-1.6	-1.6	1.2	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.6	1.0	0.9	-0.9	1.2
Major Depression (MDD)	0.7	0.8	1.2	-0.9	-0.9	0.5	-1.1
Cardiovascular Disease	0.7	2.4	3.0	-1.7	-1.7	0.7	-1.7
Neuroticism	0.7	1.7	2.6	1.6	1.3	0.5	1.5
Angina	0.7	1.0	1.4	-1.2	-1.1	0.7	-1.0
Medication: Metformin	0.7	1.0	1.8	1.3	0.9	0.3	1.1
Waist circumference	0.7	2.4	3.7	1.9	1.9	0.3	1.6
Mouth/teeth dental problems: Dentures	0.7	1.1	2.0	1.3	1.4	-0.5	0.7
Asthma	0.7	1.3	1.8	-1.3	-1.3	0.5	-1.3
Tense / ‘highly strung’	0.7	1.2	1.9	1.3	1.4	-0.2	1.2
Angina (self-reported)	0.7	1.0	1.4	-1.2	-1.1	0.5	-1.0
Mean time to correctly identify matches	0.7	1.3	4.1	0.3	0.6	-2.0	0.7
Guilty feelings	0.7	1.0	3.9	-0.1	-0.3	2.0	0.0
Allergy or Eczema	0.6	1.5	2.0	-1.3	-1.3	1.4	-0.8
Hypothyroidism (self reported)	0.6	1.5	1.9	-1.1	-1.1	1.4	-1.3
Respiratory disease	0.6	1.4	1.9	-1.3	-1.4	0.7	-1.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	1.0	0.9	0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.0	1.0	0.9	-0.4	0.8
Trunk fat percentage	0.6	2.2	3.8	1.7	1.9	0.1	1.5
Age when periods started (menarche)	0.6	1.5	1.9	-1.1	-1.4	-1.1	-1.4
High blood pressure	0.6	1.6	2.0	-1.3	-1.4	0.9	-1.4
Father’s age at death	0.6	0.8	1.2	-1.1	-0.8	0.6	-1.1
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	-1.0	-0.9	0.5	-1.2
Medication: Cholesterol lowering	0.6	0.9	1.6	-1.0	-0.7	1.3	-0.7
Prospective memory result	0.6	0.7	1.1	1.0	0.8	0.7	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.3	1.1	0.8	-0.6	0.9
Body fat percentage	0.6	2.2	3.8	1.7	1.9	-0.3	1.4
Emphysema/chronic bronchitis	0.6	0.7	0.9	0.9	0.9	0.5	0.9
Long-standing illness, disability or infirmity	0.6	0.8	3.2	-0.1	-0.3	1.8	0.2
Friendships satisfaction	0.6	0.8	0.9	-0.9	-0.8	0.9	-0.9
Breast cancer (self-reported)	0.6	0.7	0.9	-0.8	-0.9	0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-0.9	-1.0	0.4	-0.8
Ulcerative Colitis	0.5	0.7	1.1	-0.9	-0.7	1.1	-0.7
Waist Hip Ratio (WHR)	0.5	2.3	3.3	1.5	1.5	1.1	1.8
Average weekly fortified wine intake	0.5	0.6	0.9	-0.9	-1.0	0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.2	1.0	0.9	-0.1	1.1
Birth weight of first child	0.5	1.0	1.5	-1.1	-1.1	0.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.9	0.7	-0.4	1.0
Health satisfaction	0.5	0.7	1.2	-0.5	-0.7	1.1	-0.9
Eye problems/disorders: None of the above	0.5	0.5	0.8	-0.9	-0.7	-0.0	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	-0.5	-0.6	1.6	-0.6
Number of full sisters	0.5	0.6	1.0	1.0	0.9	-0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	-0.3	-0.6	1.3	-0.7
Ever had bowel cancer screening	0.5	0.6	0.9	0.4	0.7	-0.9	0.9
Eye problems/disorders: Cataract	0.5	0.5	1.2	0.5	0.5	1.1	0.6
Asthma (self-reported)	0.5	0.9	1.2	-1.0	-1.1	0.5	-1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	0.9	0.7	0.3	1.0
Alcohol drinker status: Never	0.5	0.6	2.2	0.2	0.2	1.5	0.1
Myopia	0.5	0.7	1.1	-1.0	-0.7	0.5	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	1.5	1.2	1.1	-0.9	1.2
Cholesterol lowering medication	0.5	0.7	1.7	-0.6	-0.7	1.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	1.1	0.7	-0.4	0.8
Leg fat mass (left)	0.5	1.8	2.7	1.5	1.6	-0.8	1.3
Mean Putamen Volume	0.4	0.5	0.9	0.9	0.7	-0.0	0.7
Triglycerides	0.4	0.7	1.4	1.1	0.0	-0.2	1.2
Systolic blood pressure, automated reading	0.4	1.2	1.6	-1.2	-1.2	-0.6	-1.3
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.7	-0.9	0.4	-0.8
Trunk fat mass	0.4	1.8	3.0	1.5	1.7	0.0	1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	-1.0	-0.8	-0.5	-0.4
Arm fat percentage (right)	0.4	1.6	2.8	1.4	1.7	0.4	1.1
Number of live births	0.4	0.5	0.8	-0.7	-0.9	0.2	-0.9
Illnesses of mother	0.4	0.5	1.9	-0.2	-0.1	1.4	-0.0
Hair/balding pattern: Pattern 4	0.4	1.0	2.8	0.6	0.6	-1.7	0.7
Birth weight	0.4	0.8	2.5	-0.5	-0.5	1.6	-0.5
Leg fat percentage (right)	0.4	1.6	2.1	1.3	1.4	-1.3	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.1	1.1	1.0	0.1	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.4	0.3	0.4	-1.2	0.2
Whole body fat mass	0.4	1.5	2.6	1.4	1.6	-0.1	1.2
Hypertension (Self-reported)	0.4	1.1	1.3	-1.0	-1.1	0.8	-1.2
Arm fat percentage (left)	0.4	1.8	3.1	1.5	1.8	0.4	1.2
Average weekly red wine intake	0.4	0.5	1.7	-0.5	-0.5	-1.3	0.0
Number of self-reported non-cancer illnesses	0.4	0.8	1.1	-1.0	-0.9	0.8	-0.7
Ever taken oral contraceptive pill	0.4	0.5	1.7	-0.3	-0.0	-1.3	-0.2
Financial situation satisfaction	0.4	0.5	2.0	0.4	0.1	1.4	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.7	0.1	0.2	1.3	0.1
High cholesterol (Self-reported)	0.4	0.6	1.9	-0.5	-0.4	1.4	-0.5
Age started oral contraceptive pill	0.4	0.4	0.6	-0.7	-0.8	0.2	-0.8
Commuting to job workplace: Cycle	0.4	0.4	0.7	-0.5	-0.8	0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.4	-0.3	-1.3	-0.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.5	0.4	-0.2	1.0
Breast Cancer	0.3	0.6	2.2	-0.4	-0.3	-1.5	-0.3
Fasting Glucose	0.3	0.3	1.2	-0.1	-0.0	1.1	-0.2
HbA1C	0.3	0.3	0.7	0.8	0.6	0.1	0.6
Hand grip strength (left)	0.3	0.8	2.9	-0.3	-0.0	-1.7	0.0
Hand grip strength (right)	0.3	0.7	2.3	0.2	0.5	-1.5	0.5
Relative age voice broke	0.3	0.4	1.1	0.6	0.4	-1.1	0.1
Body mass index (BMI)	0.3	1.3	2.4	1.4	1.5	-0.3	1.0
Alcohol usually taken with meals	0.3	0.5	1.2	-0.6	-0.4	-1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.7	-0.2	0.1	-1.6	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.5	0.7	0.6	0.4	0.7
Medication: Ramipril	0.3	0.4	0.7	0.8	0.7	-0.1	0.7
Impedance of arm (right)	0.3	1.5	3.9	-0.8	-0.8	2.0	-0.8
Alcohol intake versus 10 years previously	0.3	0.4	0.5	0.6	0.7	-0.6	0.7
Worrier / anxious feelings	0.3	0.5	0.9	1.0	0.7	0.5	0.6
Noisy workplace	0.3	0.4	0.7	0.9	0.7	0.3	0.6
Medication: Lansoprazole	0.3	0.3	1.0	0.0	-0.3	-1.0	-0.5
Arm fat mass (right)	0.3	1.1	2.0	1.2	1.4	0.2	0.9
High blood pressure (siblings)	0.3	0.5	0.7	0.7	0.5	-0.9	0.6
Pulse wave peak to peak time	0.3	0.3	0.7	-0.8	-0.4	0.2	-0.6
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	-0.6	0.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.9	0.6	0.4	0.5
Neck or shoulder pain in last month	0.3	0.4	0.6	0.7	0.4	0.8	0.6
Medication: Allopurinol	0.3	0.4	0.5	-0.7	-0.7	0.6	-0.6
Medication: Omeprazole	0.3	0.4	1.5	0.1	0.1	-1.2	-0.0
Leg fat mass (right)	0.3	1.2	1.8	1.2	1.3	-0.7	0.9
Family relationship satisfaction	0.3	0.4	0.7	0.5	0.5	0.8	0.5
Medication: Aspirin	0.3	0.4	0.6	0.6	0.7	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	0.7	0.7	1.1	0.6
Diabetes diagnosed by doctor	0.3	0.5	0.8	-0.6	-0.9	0.8	-0.7
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.4	-0.6	0.8	-0.1
Arm fat mass (left)	0.3	1.3	2.3	1.4	1.5	0.4	1.0
Wears glasses or contact lenses	0.3	0.4	0.6	0.7	0.6	0.5	0.8
Medication: Bendroflumethiazide	0.3	0.5	0.8	0.9	0.9	0.1	0.7
Medication: Paracetamol	0.3	0.4	1.1	0.5	0.4	-1.1	0.5
Risk taking	0.3	0.5	0.9	0.6	0.9	-0.5	0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.2	-0.3	1.2	0.1
Pain experienced in last month	0.3	0.5	1.8	0.3	0.1	-1.4	0.1
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	0.1	0.0	-1.0	0.6
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	0.0	-0.5	0.6
Schizophrenia (2018)	0.2	0.5	0.9	-1.0	0.0	-0.4	-0.9
Worry (Nagel 2018)	0.2	0.5	0.8	0.9	0.8	-0.1	0.7
Reaction Time	0.2	0.4	1.6	0.0	0.2	-1.3	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.9	-0.8	0.2	-0.7
Crohns Disease (2012)	0.2	0.3	1.1	-0.3	-0.3	1.1	0.1
Schizophrenia (2014)	0.2	0.3	0.5	-0.7	0.0	-0.7	-0.7
BMI	0.2	1.0	1.6	1.1	1.3	-0.7	0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.5	-0.7	0.8	-0.4
Lung FEV1/FVC ratio	0.2	1.1	4.2	0.3	0.2	-2.0	0.2
Number of treatments/medications taken	0.2	0.4	0.7	-0.7	-0.8	-0.2	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.8	0.7	-0.1	0.6
Relative age of first facial hair	0.2	0.4	0.7	-0.3	-0.5	0.9	-0.7
Current tobacco smoking	0.2	0.4	1.3	0.3	0.1	1.2	-0.0
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.6	-0.5	0.0	-0.7
Number of incorrect matches in round	0.2	0.4	0.5	0.7	0.6	-0.3	0.7
Past tobacco smoking	0.2	0.3	0.6	-0.7	-0.5	-0.3	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.7	0.2	-0.3	0.5
Impedance of arm (left)	0.2	1.1	3.2	-0.7	-0.6	1.8	-0.6
Medication: Paracetamol	0.2	0.4	0.7	0.5	0.5	-0.8	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	1.0	0.6	0.0	0.6
Medication: Amlodipine	0.2	0.2	0.7	0.2	-0.1	0.8	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	-0.4	-0.5	0.5	-0.7
Medication: Blood pressure	0.2	0.3	0.6	-0.4	-0.2	-0.8	-0.5
Heart disease (mother)	0.2	0.2	0.8	0.0	-0.1	-0.9	0.0
Overall health rating	0.2	0.5	1.7	0.4	0.0	1.3	0.3
Supplements: Vitamin C	0.2	0.2	0.7	0.0	0.0	-0.9	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.1	-0.1	0.9	0.2
Medication for cholesterol	0.2	0.3	0.6	-0.8	-0.4	0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.6	-0.6	-0.1	-0.2
Back pain experienced in last month	0.2	0.2	0.8	0.4	0.0	0.9	0.2
Medication: Aspirin	0.2	0.3	0.9	0.3	0.4	-0.9	0.3
Smoking status: Current	0.2	0.3	1.3	0.2	0.0	1.1	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.6	0.6	-0.2	0.6
Irritability	0.2	0.3	0.4	0.6	0.6	-0.3	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.3	0.1	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.3	0.0	0.0	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.0	0.0	-0.1	-0.7
Blood Red Count	0.1	0.5	1.2	-0.3	-0.3	-1.1	-0.8
Heel T-Score	0.1	0.6	1.9	-0.5	-0.3	-1.4	-0.5
Chronotype (morning person)	0.1	0.1	0.3	0.2	0.4	0.0	0.5
Hair Pigment	0.1	1.5	2.2	1.3	1.5	-0.2	1.4
Tanning	0.1	1.5	1.7	-1.3	-1.3	1.1	-1.2
Medication: Co-codamol	0.1	0.1	0.2	0.1	-0.3	-0.4	-0.0
Impedance of leg (right)	0.1	0.3	1.0	-0.1	-0.3	-1.0	0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.1	0.1	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-0.0	0.2	-1.0	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	-0.0	0.4	0.4
Supplements: Glucosamine	0.1	0.1	0.2	0.2	0.4	-0.3	0.3
Impedance of leg (left)	0.1	0.3	1.1	0.2	0.0	-1.1	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.3	0.3	-0.5	0.4
Fluid intelligence score	0.1	0.3	0.4	-0.6	-0.5	0.1	-0.6
Illnesses of siblings	0.1	0.2	0.7	-0.2	-0.1	0.8	-0.2
Weight	0.1	0.6	0.9	0.9	0.9	0.3	0.6
Hip circumference	0.1	0.3	0.7	0.7	0.8	-0.1	0.4
Happiness	0.1	0.1	0.2	-0.2	-0.3	0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.3	-0.6	-0.7	-0.5
Lung cancer (father)	0.1	0.2	0.4	0.6	0.5	0.0	0.3
Length of working week for main job	0.1	0.1	0.2	0.1	0.2	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.1	-0.1	0.9	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.4	-0.2	0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.5
Headache pain in last month	0.1	0.2	0.3	0.5	0.4	0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.3	-0.2	0.6	-0.4
Arm fat-free mass (right)	0.1	0.3	0.5	0.7	0.5	-0.5	0.6
Comparative body size at age 10	0.1	0.3	0.9	-0.2	-0.4	0.9	-0.3
Worry too long after embarrassment	0.1	0.1	0.3	-0.2	-0.4	-0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2
Qualifications: College or University degree	0.1	0.4	0.9	-0.9	-0.7	0.2	-0.5
Medication: Ibuprofen	0.1	0.1	0.2	0.4	0.3	-0.3	0.5
Arm predicted mass (right)	0.1	0.4	0.7	0.8	0.6	-0.4	0.7
Alcohol intake frequency.	0.1	0.2	1.0	-0.0	-0.0	1.0	-0.0
Leg pain on walking	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.4
Knee pain experienced in last month	0.1	0.1	0.2	0.1	0.2	0.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	-0.4	-0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.2	0.3	-0.6	0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	0.1	0.4	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.5	0.3	0.0	0.4
Ever smoked	0.1	0.2	0.4	0.2	0.1	0.6	0.5
Number of operations (self-reported)	0.1	0.1	0.4	0.2	-0.1	0.6	0.1
Average weekly beer plus cider intake	0.1	0.2	0.8	0.1	0.1	0.9	0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.3	0.0	-0.6	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	-0.1
Ovarian Cancer	0.0	0.0	0.0	0.1	-0.0	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.1	-0.2	0.0	0.1	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.1	0.3	-0.2	-0.1
Blood White Count	0.0	0.2	0.3	-0.2	-0.2	0.6	-0.5
Height	0.0	0.5	0.8	0.9	0.4	0.8	0.8
Lung FVC	0.0	0.1	0.1	-0.2	-0.1	0.3	0.3
Leg fat-free mass (left)	0.0	0.3	0.4	0.7	0.5	0.4	0.4
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	-0.0	-0.3	0.1
Medication: Atenolol	0.0	0.0	0.1	0.3	0.1	0.0	0.3
Sitting height	0.0	0.3	1.0	0.2	-0.0	-1.0	-0.0
Leg predicted mass (left)	0.0	0.2	0.2	0.5	0.4	0.4	0.2
Nervous feelings	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.0
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.1	0.2	0.1	0.2
Had other major operations	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.1	-0.1	-0.1	0.4	0.3
Pain all over the body in last month	0.0	0.0	0.0	-0.2	-0.0	-0.1	0.0
Trunk fat-free mass	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.3	-0.2	0.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.0	-0.0	0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.4	-0.3	0.3	0.1
Trunk predicted mass	0.0	0.0	0.1	-0.0	-0.3	0.2	-0.1
Standing height	0.0	0.5	0.9	-0.5	-0.8	1.0	-0.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	-0.2	-0.2	0.3	0.4
Suffer from ‘nerves’	0.0	0.1	0.2	0.3	0.1	0.5	-0.0
Had major operations	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.2	-0.1	0.0	0.4	0.1
Whole body fat-free mass	0.0	0.0	0.1	0.2	0.0	0.3	0.1
Leg fat-free mass (right)	0.0	0.2	0.4	0.6	0.5	0.4	0.3
Medication: Gliclazide	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.1	0.1	-0.0	0.4
Whole body water mass	0.0	0.0	0.1	0.3	0.0	0.3	0.1
Leg predicted mass (right)	0.0	0.2	0.3	0.6	0.4	0.5	0.3
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.3	0.0	-0.3	-0.0
Basal metabolic rate	0.0	0.1	0.2	0.5	0.3	0.2	0.3
Arm fat-free mass (left)	0.0	0.1	0.2	0.5	0.2	-0.3	0.2
Ever depressed for a whole week	0.0	0.0	0.1	0.1	-0.0	0.3	0.0
Impedance of whole body	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1
Arm predicted mass (left)	0.0	0.2	0.4	0.6	0.4	-0.4	0.4

Hub : Genes

AP1G2

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Trait associations