TWAS hub - SLC7A8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0664	0.0227	1.9e-03	-0.002	0.020	0.013	0.019	-0.001	0.990	4.2e-04	4.3e-03	5.9e-04	4.0e-01
2	NTR	Blood	0.0922	0.0224	7.1e-07	0.004	0.032	0.050	0.054	0.046	0.015	1.1e-10	1.1e-15	6.6e-17	1.0e-14
3	ROSMAP	Brain Pre-frontal Cortex	0.0593	0.0299	2.9e-02	0.002	0.008	0.026	0.015	0.000	0.160	2.5e-02	2.1e-04	4.7e-03	3.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	9.0	29.0	83.7	9.2	-1.6	-0.7
Blood Eosinophil Count	5.3	40.7	72.2	-8.5	-6.0	-3.8
Ever had hysterectomy (womb removed)	3.5	3.9	10.0	3.2	-0.8	1.1
Current tobacco smoking	3.4	5.6	8.3	2.9	2.6	-1.4
Pulse rate	3.4	5.8	16.4	4.0	-0.3	-0.9
Financial situation satisfaction	3.3	4.1	11.0	3.3	-0.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.1	9.5	-0.9	-3.1	1.3
Smoking status: Current	2.9	4.7	6.1	2.4	2.5	-1.4
Qualifications: CSEs or equivalent	2.8	3.7	9.4	3.1	-0.0	-1.2
Prostate Cancer	2.6	3.6	9.2	3.0	-0.7	1.0
Average weekly beer plus cider intake	2.6	3.8	4.9	2.1	2.2	-1.4
Average weekly fortified wine intake	2.5	2.9	6.9	-0.7	-1.1	-2.6
Chest pain or discomfort	2.5	3.5	8.7	3.0	0.6	-1.2
Breastfed as a baby	2.4	3.0	7.0	-1.2	-2.6	-0.8
Ovarian Cancer	2.3	3.1	8.0	0.7	-0.9	-2.8
Guilty feelings	2.3	3.5	6.2	2.5	-1.7	-1.2
Ever used hormone-replacement therapy (HRT)	2.2	2.8	7.3	-2.7	-0.9	0.5
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.8	2.2	0.7	1.5
Had major operations	2.1	2.4	3.2	1.4	1.5	1.8
Schizophrenia vs Biploar Disorder	2.0	2.7	2.8	-1.7	-1.7	-1.6
Time employed in main current job	2.0	2.3	4.2	1.6	2.0	0.4
Medication: Ibuprofen	2.0	2.4	4.8	-1.2	-2.2	0.9
Myopia	2.0	2.8	3.5	1.7	1.9	1.5
Triglycerides	1.8	2.9	4.5	2.1	1.2	1.7
Impedance of arm (left)	1.8	8.2	15.4	3.9	1.3	-2.8
Loneliness, isolation	1.8	2.4	2.7	1.6	-1.5	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	2.5	-1.2	-1.5	1.6
Osteoarthritis (self-reported)	1.8	2.3	3.9	-2.0	-1.5	0.8
Neuroticism (Nagel 2018)	1.7	4.0	5.4	2.3	-2.2	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	6.8	0.4	0.0	-2.6
Supplements: Glucosamine	1.7	2.2	4.8	-2.2	-1.3	-0.4
Prospective memory result	1.7	2.0	4.8	1.1	2.2	-0.4
Average weekly red wine intake	1.7	2.5	3.9	-2.0	-0.7	-1.7
HbA1C	1.6	1.7	3.8	2.0	-0.9	-0.8
Neuroticism (2016)	1.6	2.3	4.2	2.0	1.5	0.7
Happiness	1.6	1.9	5.7	2.4	0.1	0.3
Medication: Gliclazide	1.6	1.9	2.0	1.4	-1.4	1.3
Alzheimer’s Disease (in father)	1.5	1.6	3.0	-0.3	-1.3	-1.7
Breast Cancer	1.5	3.6	5.2	-2.2	-1.0	2.3
Neck or shoulder pain in last month	1.5	2.1	3.0	1.7	1.7	-0.7
Friendships satisfaction	1.5	1.8	5.2	2.3	0.5	0.3
Mineral and other dietary supplements	1.5	2.1	3.7	1.9	1.3	-0.9
Supplements: Calcium	1.5	1.7	3.9	-2.0	-0.9	-0.7
Average weekly spirits intake	1.4	1.7	3.1	-0.2	-1.4	-1.8
Medication: Ramipril	1.4	1.7	4.2	2.0	-0.5	-0.9
Smoking status: Previous	1.4	2.2	5.5	-1.0	-2.3	0.1
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.2	2.0	0.7	0.8
Age started oral contraceptive pill	1.4	1.8	4.0	-1.1	-2.0	0.5
Impedance of whole body	1.4	6.9	9.5	3.1	1.4	-3.0
Depressed Affect (Nagel 2018)	1.3	2.6	3.1	1.6	-1.8	-1.5
Depression (self-reported)	1.3	1.6	3.2	-0.4	-1.8	-1.1
Loud music exposure frequency	1.3	1.5	2.6	0.3	1.6	-1.3
Commuting to job workplace: Public transport	1.3	1.5	2.3	-1.5	-1.5	0.1
Alcohol drinker status: Previous	1.3	1.5	3.5	0.9	-1.9	-0.4
Lung FEV1/FVC ratio	1.2	6.2	10.6	-3.3	-1.2	2.6
Neuroticism	1.2	2.8	5.0	2.2	-1.6	-1.0
Medication for hormone replacement therapy	1.2	1.3	2.1	-1.3	-0.5	1.5
Medication: Co-codamol	1.2	1.4	3.7	-1.9	0.4	0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.5	-0.7	-0.9	-1.9
Worry too long after embarrassment	1.2	1.9	5.4	0.4	-2.3	-0.6
Mood swings	1.2	2.2	3.4	1.0	-1.8	-1.5
Risk taking	1.2	1.8	5.0	-0.5	0.4	2.2
Bipolar Disorder (2018)	1.1	1.7	2.1	1.1	1.4	1.3
Age at First Birth	1.1	1.5	2.4	-1.6	-1.2	-0.9
Past tobacco smoking	1.1	1.9	4.3	0.4	2.1	1.2
Impedance of arm (right)	1.1	5.1	7.7	2.8	1.3	-2.5
Noisy workplace	1.1	1.3	2.2	0.9	1.5	0.9
Birth weight	1.1	2.4	5.8	-0.8	-0.7	-2.4
Medication for pain relief, constipation, heartburn	1.1	1.9	3.9	-0.9	2.0	-1.0
Angina (self-reported)	1.1	1.4	3.6	1.9	0.5	-0.6
Family relationship satisfaction	1.1	1.4	4.0	2.0	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.6	-0.2	-1.2	-1.6
Illnesses of siblings: Diabetes	1.1	1.4	2.4	1.6	1.3	0.0
Wears glasses or contact lenses	1.1	1.3	3.5	-0.7	-1.9	-0.1
Mother’s age at death	1.1	1.4	2.7	-1.0	-0.7	1.6
Depression (Nagel 2018)	1.0	1.5	4.3	0.5	0.1	-2.1
Hypothyroidism (self reported)	1.0	2.3	4.3	-1.3	-0.9	-2.1
Impedance of leg (left)	1.0	4.6	9.8	1.5	1.4	-3.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.2	-0.1	-1.3	-1.5
Hair/balding pattern: Pattern 3	1.0	1.5	2.5	-1.4	0.3	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.4	-1.3	0.2	-1.5
Breast cancer (self-reported)	1.0	1.2	2.3	-1.5	1.1	0.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.5	-1.2	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.4	-1.6	-0.2	1.2
Medication: Atorvastatin	1.0	1.2	2.4	-0.9	0.6	1.6
Ever smoked	1.0	1.8	2.5	0.8	-1.5	-1.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.1	-1.5	-0.4	-1.1
Fasting Glucose	0.9	1.1	1.9	-1.2	-1.4	0.3
Primary Biliary Cirrhosis	0.9	1.3	2.3	-0.2	1.3	1.5
Hearing difficulty/problems: Yes	0.9	1.3	2.0	-1.4	-1.2	-0.7
Impedance of leg (right)	0.9	4.5	9.2	1.4	1.5	-3.0
High blood pressure (mother)	0.9	1.3	1.9	-1.0	-0.9	-1.4
Father’s age at death	0.9	1.2	2.7	-1.6	-0.9	-0.2
Lung cancer (father)	0.9	1.1	1.8	-1.4	0.9	0.8
Tense / ‘highly strung’	0.9	1.4	2.5	1.6	-0.1	1.3
Pulse wave reflection index	0.9	1.1	1.6	-1.3	-1.0	-0.8
Headache pain in last month	0.9	1.5	3.8	1.9	-0.1	0.8
Comparative body size at age 10	0.9	2.4	5.1	-1.1	-0.9	2.3
Qualifications: College or University degree	0.9	2.9	4.4	-2.0	-2.1	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.7	1.0	1.3	0.6
Emphysema/chronic bronchitis	0.9	1.0	1.4	0.8	-0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	2.8	1.7	0.7	-0.3
Suffer from ‘nerves’	0.9	1.4	3.0	1.7	-1.0	-0.0
Age at last live birth	0.9	1.3	2.7	-1.7	-0.5	-0.9
Knee pain experienced in last month	0.9	1.4	2.9	-1.7	-1.0	-0.4
Worry (Nagel 2018)	0.8	1.6	2.4	1.6	-1.5	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	1.4	-1.2	-1.1	-1.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.4	-1.0	0.0	1.6
Had other major operations	0.8	1.0	3.0	-1.7	-0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	1.9	1.2	-0.9	-1.4
Illnesses of mother	0.8	1.0	2.1	0.8	1.5	-0.4
Length of working week for main job	0.8	0.8	2.2	-0.4	-0.5	-1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.2	1.5	-1.2	-0.5
Number of full brothers	0.8	1.1	1.6	0.3	1.2	1.3
Health satisfaction	0.8	1.0	2.5	1.6	0.7	0.0
Medication: Allopurinol	0.8	1.1	1.6	0.7	1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.4	0.8	-1.2	-0.9
Supplements: Vitamin C	0.8	0.9	2.6	-1.6	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	-1.3	0.9	-0.5
Hearing aid user	0.8	0.9	2.5	0.2	1.6	-0.1
Alcohol drinker status: Never	0.8	0.9	1.8	1.0	1.3	-0.2
Schizophrenia (2014)	0.7	1.5	4.2	-0.4	-2.0	0.3
Heel T-Score	0.7	5.2	11.1	-3.3	-0.2	2.1
Waist Hip Ratio (WHR)	0.7	3.2	5.3	1.3	1.6	-2.3
Angina	0.7	0.9	2.7	1.6	0.3	-0.2
Severe depression (siblings)	0.7	0.7	1.1	0.3	-1.1	1.0
Serious illness, injury or assault to yourself	0.7	0.9	2.2	0.1	1.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	1.0	0.4	-1.2
Medication: Levothyroxine sodium	0.7	1.2	2.1	-1.4	-0.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	1.6	-1.2	-1.1	-1.3
Illnesses of father: None of the above (group 1)	0.7	0.9	2.6	-1.6	0.1	-0.1
Illnesses of father: High blood pressure	0.7	0.8	2.5	1.6	0.1	-0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	-1.1	-0.5	-1.0
Fractured/broken bones in last 5 years	0.7	0.9	1.7	1.3	-0.6	-0.8
Pain experienced in last month	0.7	1.2	3.2	-1.8	-0.4	-0.4
Rheumatoid Arthritis	0.6	0.8	2.0	-0.5	1.4	-0.6
Fed-up feelings	0.6	1.0	2.2	0.8	-0.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.8	-1.9	-0.1	-0.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.0	0.8	1.0	-0.7
Had menopause	0.6	0.8	1.8	-1.3	0.6	0.3
Heart attack	0.6	0.8	1.9	1.4	0.1	-0.6
Neuroticism score	0.6	1.3	2.3	1.5	-1.0	-0.8
Number of live births	0.6	0.8	1.7	0.9	0.0	-1.3
Peak expiratory flow (PEF)	0.6	1.5	2.9	1.7	-1.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	-1.3	-0.4	0.8
Medication: Paracetamol	0.6	0.9	2.0	0.9	-1.4	0.1
Gout (self-reported)	0.6	0.9	1.6	1.0	1.3	0.4
Medication: Amlodipine	0.6	0.8	1.0	0.7	-1.0	1.0
Wheeze or whistling in the chest in last year	0.6	1.1	3.0	1.7	-0.0	-0.5
Number of children fathered	0.6	0.6	1.1	0.4	0.8	-1.1
Medication: Omeprazole	0.6	0.7	1.0	1.0	-0.9	-0.5
Long-standing illness, disability or infirmity	0.6	0.9	1.7	1.3	0.7	-0.8
Medication for cholesterol	0.6	0.9	1.9	0.3	0.8	-1.4
Back pain experienced in last month	0.6	0.8	2.3	1.5	0.4	0.3
High cholesterol (Self-reported)	0.6	1.1	2.7	-0.6	-0.5	1.7
Arm fat-free mass (left)	0.6	2.9	4.4	-2.1	-1.3	1.6
Number of operations (self-reported)	0.6	1.0	2.4	0.2	0.7	1.5
Ever depressed for a whole week	0.6	0.8	1.3	-1.1	-1.0	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	1.9	-1.3	-1.1	-1.4
Schizophrenia (2018)	0.5	1.0	2.6	0.4	-1.6	0.6
Mean Putamen Volume	0.5	0.6	1.7	0.3	-0.2	1.3
LDL Cholesterol	0.5	0.8	2.0	0.6	-0.2	1.4
Systolic Blood Pressure	0.5	2.3	6.1	-0.5	2.5	0.7
Allergy or Eczema	0.5	1.4	2.2	-1.3	-1.5	-0.7
Systolic blood pressure, automated reading	0.5	1.4	3.2	-0.7	1.8	-0.7
Diabetes (father)	0.5	0.6	0.9	0.6	0.7	0.9
Maternal smoking around birth	0.5	0.7	1.9	1.4	0.3	0.2
Nervous feelings	0.5	1.0	1.1	0.8	-1.0	-1.1
Mouth/teeth dental problems	0.5	0.8	1.5	-1.2	-0.6	-0.7
Diabetes (self-reported)	0.5	0.7	1.8	-1.3	-0.6	0.1
Hip circumference	0.5	2.3	2.7	-1.4	-1.6	1.5
Alcohol intake versus 10 years previously	0.5	0.7	1.4	0.9	1.2	0.1
Worrier / anxious feelings	0.5	0.9	1.9	0.9	-1.4	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.0	0.4	1.3
Asthma	0.5	1.0	2.8	1.7	0.6	-0.2
Exposure to tobacco smoke at home	0.5	0.5	0.8	0.8	0.9	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	0.9	1.0	-0.7	-0.9
Birth weight of first child	0.5	1.0	2.0	0.7	-1.4	0.6
High blood pressure (siblings)	0.5	0.7	1.0	0.7	-0.7	-1.0
Exposure to tobacco smoke outside home	0.5	0.6	1.3	0.3	1.1	0.7
Diabetes diagnosed by doctor	0.5	0.8	1.6	-0.8	-1.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	-0.1	0.9	0.8
Osteoporosis (self-reported)	0.5	0.7	1.4	-0.2	-0.7	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	1.3	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	1.0	0.8	-0.6
Arm predicted mass (left)	0.5	2.7	4.4	-2.1	-1.2	1.5
Reaction Time	0.4	0.7	1.6	0.5	1.2	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	-1.5	-0.8	-0.5
Smoking Status	0.4	1.1	1.9	1.1	-1.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.8	-1.2	-0.0
Number of treatments/medications taken	0.4	0.8	1.9	-0.6	-1.4	0.1
Sensitivity / hurt feelings	0.4	0.7	1.1	1.0	-0.3	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	0.7	-1.0	-0.6
Relative age of first facial hair	0.4	0.8	2.2	0.3	-1.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	-0.6	0.7	-0.8
Vitamin and mineral supplements	0.4	0.5	1.1	0.5	1.0	-0.3
Diabetes (mother)	0.4	0.5	0.9	1.0	0.7	-0.4
Hand grip strength (right)	0.4	1.0	1.6	0.9	-0.6	-1.3
Relative age voice broke	0.4	0.6	1.4	-0.3	-1.2	-0.4
Taking other prescription medications	0.4	0.6	1.7	-0.2	-0.1	-1.3
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.3	0.0	-1.1
Body mass index (BMI)	0.4	1.7	2.0	-1.2	-1.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	-0.2	-1.4	-0.2
Fluid intelligence score	0.4	0.9	1.6	-0.6	-1.3	-0.9
Trunk fat-free mass	0.4	2.4	4.6	-2.1	-1.1	1.2
Falls in the last year	0.4	0.6	1.1	1.1	-0.7	0.2
Medication: Cholesterol lowering	0.4	0.6	1.5	-0.4	0.4	1.2
Pulse wave Arterial Stiffness index	0.4	0.4	1.3	0.1	0.2	-1.1
Trunk predicted mass	0.4	2.4	4.6	-2.1	-1.1	1.1
Pulse wave peak to peak time	0.4	0.4	1.0	-0.0	-0.5	1.0
Heart disease (mother)	0.4	0.4	1.2	-0.2	-1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	0.9	0.1	0.8
Qualifications: nursing, teaching	0.4	0.6	1.7	0.4	-1.3	0.2
Commuting to job workplace: Walk	0.4	0.4	1.0	0.2	-0.4	1.0
Medication: Aspirin	0.4	0.5	1.4	1.2	0.1	0.4
Medication: Lisinopril	0.4	0.5	1.1	-1.0	0.3	0.6
Diastolic blood pressure, automated reading	0.4	1.2	2.3	1.5	0.6	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.6	1.0	1.0	-0.2	0.9
Major Depression (MDD)	0.3	0.4	1.2	0.1	-0.0	1.1
Lupus	0.3	0.5	1.0	1.0	0.7	0.1
Ulcerative Colitis	0.3	0.5	1.0	-0.2	0.5	1.0
Hand grip strength (left)	0.3	0.8	1.0	-0.6	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.6	-0.1	0.7
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.4	0.3	-0.9
Age when periods started (menarche)	0.3	0.8	1.1	0.4	-1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	0.3	-0.7	0.7
High blood pressure	0.3	0.8	2.5	-0.0	0.2	1.6
Multivitamins +/- minerals	0.3	0.4	1.2	0.2	-0.3	-1.1
Medication: Atenolol	0.3	0.4	0.5	0.4	-0.7	-0.7
Alcohol usually taken with meals	0.3	0.5	1.0	1.0	0.6	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	-0.5	0.2	0.9
Financial difficulties in last 2 years	0.3	0.4	0.6	0.8	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	1.1	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.2	-1.5	-0.4	-0.4
Glaucoma (self-reported)	0.3	0.4	0.8	0.4	-0.3	0.9
Arm fat-free mass (right)	0.3	1.3	1.8	-1.4	-1.1	1.0
Shortness of breath walking on level ground	0.3	0.4	0.7	0.1	0.6	0.8
Mean time to correctly identify matches	0.3	0.6	1.3	0.5	1.1	-0.5
Arm predicted mass (right)	0.3	1.4	1.7	-1.3	-1.2	1.0
Overall health rating	0.3	0.7	1.2	1.1	-0.3	-0.9
Leg pain on walking	0.3	0.4	1.2	-0.2	1.1	0.0
Medication: Aspirin	0.3	0.4	0.7	0.8	0.2	0.7
Whole body fat-free mass	0.3	1.9	2.2	-1.5	-1.1	1.5
Asthma (self-reported)	0.3	0.6	1.6	1.3	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	-1.4	-0.4	-0.3
Whole body water mass	0.3	1.9	2.2	-1.5	-1.1	1.5
Miserableness	0.3	0.6	1.5	0.4	-1.2	-0.1
Basal metabolic rate	0.3	1.6	1.8	-1.3	-1.2	1.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.5	-0.4	-0.5	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	1.0	-0.5	-0.1
Ulcerative Colitis (UC)	0.2	0.4	1.1	0.3	-0.0	1.0
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.9	-0.4	0.0
HDL Cholesterol	0.2	0.4	0.8	-0.9	-0.5	-0.3
Blood Platelet Count	0.2	2.1	3.2	-1.8	0.1	-1.8
Blood White Count	0.2	1.7	2.3	-1.0	-1.3	-1.5
BMI	0.2	1.0	1.7	-1.0	-0.6	1.3
Respiratory disease	0.2	0.4	0.5	0.7	-0.6	-0.7
Lung FVC	0.2	1.1	2.3	-0.6	-0.8	-1.5
Supplements: Zinc	0.2	0.3	0.6	-0.8	0.3	-0.4
Leg fat-free mass (left)	0.2	1.1	2.1	-0.6	-0.9	1.4
Trunk fat percentage	0.2	0.8	1.4	1.2	-0.7	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.3	0.7	0.2
Leg predicted mass (left)	0.2	1.2	2.1	-0.6	-1.0	1.5
Waist circumference	0.2	0.6	1.0	-0.8	-1.0	0.4
Number of incorrect matches in round	0.2	0.3	0.7	-0.4	-0.3	0.8
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.5	-0.8	0.3
Forced vital capacity (FVC)	0.2	0.6	1.6	0.3	0.4	-1.3
Qualifications: None of the above	0.2	0.4	0.6	-0.7	0.8	0.5
Pain all over the body in last month	0.2	0.2	0.3	0.5	0.3	-0.3
Illnesses of siblings	0.2	0.3	0.8	-0.1	-0.0	0.9
Weight	0.2	1.0	1.6	-1.0	-1.3	0.6
Arm fat percentage (right)	0.2	0.6	1.8	-0.1	-1.3	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.9	-0.5	-0.4
Arm fat mass (right)	0.2	0.9	1.9	-0.6	-1.4	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	0.3	-0.0	1.1
Blood clot in the leg (DVT)	0.2	0.3	0.6	0.8	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.1	0.7	0.4
Medication: Blood pressure	0.2	0.4	0.8	0.7	-0.1	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.2	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	0.5	-0.7	0.4
Leg fat-free mass (right)	0.2	1.2	1.9	-0.7	-1.2	1.4
Arm fat percentage (left)	0.2	0.7	1.5	0.6	-1.2	0.3
Eye problems/disorders: Cataract	0.2	0.3	0.8	-0.1	0.2	-0.9
Leg predicted mass (right)	0.2	1.3	2.1	-0.7	-1.1	1.5
Arm fat mass (left)	0.2	0.8	2.0	-0.3	-1.4	0.6
Irritability	0.2	0.3	0.9	0.1	0.9	-0.3
Heart disease (siblings)	0.2	0.3	0.4	0.6	0.6	0.3
Pack years of smoking	0.2	0.3	0.8	-0.9	-0.5	0.3
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	-0.3	0.6	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.6	0.2	0.7
Crohns Disease (2012)	0.1	0.2	0.3	-0.6	0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.0	0.1
Blood Red Count	0.1	0.8	2.0	0.2	-1.4	-0.7
Cardiovascular Disease	0.1	0.4	0.7	-0.4	0.5	0.8
Chronotype (morning person)	0.1	0.3	0.4	0.6	-0.5	0.4
Tanning	0.1	0.7	1.3	1.1	0.4	-0.8
Pack years adult smoking proportion	0.1	0.1	0.1	-0.3	-0.2	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.7	-0.2	-0.4
Trunk fat mass	0.1	0.4	0.9	0.4	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.9	-0.1	-0.1
Allergy	0.1	0.3	0.7	-0.9	-0.1	0.3
Medication: Simvastatin	0.1	0.2	0.4	-0.2	-0.6	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.3	-0.3	-0.8
Standing height	0.1	0.6	1.5	0.5	-0.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	0.6	0.1	-0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	-0.6	0.2	-1.1
Body fat percentage	0.1	0.6	0.9	0.7	-1.0	-0.6
Leg fat percentage (right)	0.1	0.3	0.9	0.0	-1.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.4	-0.0
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.5	-0.1	0.4
Migraine (self-reported)	0.1	0.1	0.2	-0.2	0.5	0.2
Whole body fat mass	0.1	0.5	1.5	0.2	-1.2	0.0
Leg fat mass (right)	0.1	0.3	0.8	-0.3	-0.9	0.4
Alcohol intake frequency.	0.1	0.3	0.6	0.8	-0.1	0.6
Comparative height size at age 10	0.1	0.4	0.8	0.1	0.6	-0.9
Hypertension (Self-reported)	0.1	0.3	0.9	0.2	-0.1	0.9
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.2	-0.3	0.6
Ever had bowel cancer screening	0.1	0.1	0.3	-0.2	0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.2	0.2	0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.1	-0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.1	0.2	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.4	0.0	0.2
Medication: Blood pressure	0.1	0.2	0.6	0.1	-0.8	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.0	0.2	0.6
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.5	-0.1
Leg fat percentage (left)	0.1	0.4	1.2	0.0	-1.1	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	0.1	-0.4	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.2	-0.2	-0.6
Cholesterol lowering medication	0.1	0.2	0.3	0.0	-0.5	0.6
Leg fat mass (left)	0.1	0.4	0.9	-0.5	-1.0	0.3
Crohns Disease (2017)	0.0	0.0	0.0	0.2	-0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.3	0.5	-0.7	0.6	0.2
Hair Pigment	0.0	1.3	2.7	-0.1	-1.0	-1.6
Medication: Metformin	0.0	0.0	0.1	-0.2	-0.2	0.1
Sitting height	0.0	0.3	0.5	-0.6	-0.3	0.7
Medication: Lansoprazole	0.0	0.0	0.1	-0.1	0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.0	0.2	0.1
Age at first live birth	0.0	0.0	0.0	-0.1	-0.1	0.0
Number of full sisters	0.0	0.0	0.1	0.2	-0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.1	-0.4	-0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.0	-0.1	0.2

Hub : Genes

SLC7A8

Models

Trait associations