Best TWAS P=8.49e-14 · Best GWAS P=1.56e-25 conditioned to 4.41e-13
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Frontal Cortex BA9 | FAM177A1 | 0.22 | 0.03 | lasso | 5 | 0.06 | 1.3e-02 | -7.8 | -5.4 | 5.5e-08 | 0.13 | 0.08 | 0.07 | FALSE |
2 | GTEx | Lung | RP11-85K15.2 | 0.12 | 0.08 | lasso | 6 | 0.06 | 4.4e-05 | 6.1 | -6.2 | 4.5e-10 | 0.16 | 0.94 | 0.00 | TRUE |
3 | GTEx | Lung | RP11-73E17.2 | 0.09 | 0.01 | lasso | 8 | 0.01 | 9.9e-02 | 1.2 | 5.3 | 1.2e-07 | -0.20 | 0.35 | 0.07 | FALSE |
4 | GTEx | Muscle Skeletal | PSMA6 | 0.13 | 0.14 | lasso | 2 | 0.12 | 4.6e-12 | 6.8 | 6.8 | 8.2e-12 | -0.23 | 1.00 | 0.00 | FALSE |
5 | GTEx | Nerve Tibial | SRP54 | 0.16 | 0.02 | enet | 14 | 0.08 | 1.3e-06 | -5.0 | -5.1 | 2.8e-07 | 0.17 | 0.76 | 0.01 | FALSE |
6 | GTEx | Testis | PPP2R3C | 0.23 | 0.22 | lasso | 3 | 0.23 | 1.6e-10 | -4.3 | 5.6 | 2.8e-08 | -0.12 | 0.99 | 0.00 | FALSE |
7 | NTR | Blood | FAM177A1 | 0.02 | 0.00 | blup | 381 | 0.01 | 6.0e-04 | 2.4 | -5.9 | 3.6e-09 | 0.33 | 0.14 | 0.14 | FALSE |
8 | NTR | Blood | NFKBIA | 0.26 | 0.09 | lasso | 10 | 0.12 | 3.4e-36 | 6.3 | 6.2 | 7.2e-10 | -0.31 | 1.00 | 0.00 | TRUE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PPP2R3C | 0.19 | 0.15 | lasso | 6 | 0.16 | 5.0e-18 | 4.7 | 5.3 | 1.2e-07 | -0.17 | 1.00 | 0.00 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KIAA0391 | 0.09 | 0.07 | enet | 6 | 0.06 | 8.1e-08 | 4.3 | 7.0 | 3.6e-12 | -0.25 | 0.97 | 0.02 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | KIAA0391 | 0.06 | 0.06 | lasso | 2 | 0.04 | 2.5e-05 | 4.3 | 5.3 | 1.5e-07 | -0.19 | 0.87 | 0.03 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PPP2R3C | 0.06 | 0.06 | blup | 51 | 0.06 | 6.4e-05 | 4.2 | 5.5 | 3.5e-08 | -0.16 | 0.28 | 0.35 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMA6 | 0.17 | 0.00 | blup | 52 | 0.05 | 8.0e-03 | 2.5 | 7.5 | 8.5e-14 | -0.24 | 0.01 | 0.38 | TRUE |