Best TWAS P=2.03e-29 · Best GWAS P=3.88e-32 conditioned to 0.275
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PIK3CD | 0.23 | 0.19 | enet | 7 | 0.18 | 1.3e-21 | -4.4 | -7.2 | 7.7e-13 | 0.70 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC45A1 | 0.04 | 0.05 | enet | 9 | 0.02 | 1.8e-03 | -7.6 | -8.3 | 6.7e-17 | -0.06 | 0.60 | 0.34 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RERE | 0.20 | 0.23 | lasso | 2 | 0.24 | 1.7e-19 | 8.8 | 9.9 | 2.6e-23 | 0.08 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | RP5-1115A15.1 | 0.14 | 0.07 | enet | 20 | 0.10 | 2.6e-08 | -11.1 | 10.1 | 5.8e-24 | 0.07 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -11.1 | 10.5 | 1.1e-25 | 0.04 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Artery Aorta | H6PD | 0.18 | 0.04 | enet | 15 | 0.08 | 4.6e-05 | -4.8 | 6.3 | 2.1e-10 | -0.08 | 0.93 | 0.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | RERE | 0.19 | 0.08 | enet | 10 | 0.14 | 8.0e-08 | 8.6 | 8.4 | 3.6e-17 | 0.11 | 0.26 | 0.70 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | RP5-1115A15.1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 7.0e-03 | 8.8 | 8.8 | 2.0e-18 | 0.09 | 0.14 | 0.79 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Male) | RP5-1115A15.1 | 0.18 | 0.07 | lasso | 3 | 0.06 | 1.7e-02 | -5.1 | 8.2 | 3.0e-16 | 0.04 | 0.02 | 0.67 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | RERE | 0.14 | 0.12 | lasso | 3 | 0.08 | 2.4e-03 | -6.3 | 6.6 | 3.2e-11 | 0.07 | 0.12 | 0.23 | FALSE |
| 11 | GTEx | Breast Mammary Tissue (Female) | TMEM201 | 0.34 | -0.01 | enet | 21 | 0.12 | 1.8e-04 | -3.4 | -8.0 | 9.6e-16 | 0.14 | 0.05 | 0.05 | TRUE |
| 12 | GTEx | Cells Transformed fibroblasts | RERE | 0.12 | 0.08 | lasso | 4 | 0.05 | 6.0e-05 | 8.5 | 8.7 | 2.4e-18 | 0.10 | 0.25 | 0.73 | FALSE |
| 13 | GTEx | Colon Transverse | H6PD | 0.39 | 0.06 | lasso | 6 | 0.04 | 4.8e-03 | -4.4 | 5.1 | 2.9e-07 | -0.06 | 0.60 | 0.02 | FALSE |
| 14 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | -11.1 | 11.1 | 2.1e-28 | 0.01 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | -11.1 | 10.7 | 1.4e-26 | 0.02 | 0.00 | 0.99 | FALSE |
| 16 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | -9.3 | 9.7 | 4.7e-22 | 0.04 | 0.06 | 0.94 | FALSE |
| 17 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | -11.1 | 11.1 | 2.2e-28 | 0.01 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Muscle Skeletal | RP5-1115A15.1 | 0.09 | 0.07 | enet | 10 | 0.06 | 1.5e-06 | -11.1 | 9.5 | 2.2e-21 | -0.04 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Nerve Tibial | RERE | 0.12 | 0.09 | enet | 16 | 0.11 | 5.6e-08 | 8.0 | 8.7 | 5.2e-18 | 0.11 | 0.96 | 0.03 | FALSE |
| 20 | GTEx | Pancreas | RERE | 0.11 | 0.12 | lasso | 4 | 0.07 | 5.9e-04 | 8.5 | 8.3 | 1.5e-16 | 0.11 | 0.05 | 0.86 | FALSE |
| 21 | GTEx | Skin Not Sun Exposed Suprapubic | RERE | 0.12 | 0.05 | lasso | 4 | 0.05 | 1.3e-03 | -9.0 | 8.1 | 7.8e-16 | 0.06 | 0.06 | 0.90 | FALSE |
| 22 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | -9.4 | 10.4 | 3.4e-25 | 0.01 | 0.01 | 0.98 | FALSE |
| 23 | GTEx | Skin Sun Exposed Lower leg | RERE | 0.14 | 0.05 | lasso | 8 | 0.08 | 4.3e-07 | -11.1 | 9.4 | 4.5e-21 | 0.02 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Skin Sun Exposed Lower leg | RP5-1115A15.1 | 0.07 | 0.03 | enet | 13 | 0.03 | 1.5e-03 | -11.1 | 9.8 | 1.1e-22 | 0.01 | 0.00 | 0.99 | FALSE |
| 25 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | -11.1 | 11.3 | 2.0e-29 | 0.02 | 0.00 | 1.00 | TRUE |
| 26 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | -11.1 | 11.2 | 6.0e-29 | 0.02 | 0.00 | 1.00 | FALSE |
| 27 | METSIM | Adipose | H6PD | 0.08 | 0.02 | enet | 13 | 0.03 | 3.3e-05 | -4.8 | 5.2 | 1.8e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 28 | METSIM | Adipose | LZIC | 0.04 | 0.01 | bslmm | 312 | 0.02 | 1.5e-03 | -5.3 | 6.7 | 2.2e-11 | -0.34 | 0.08 | 0.31 | TRUE |
| 29 | METSIM | Adipose | RBP7 | 0.14 | 0.07 | enet | 17 | 0.07 | 1.0e-10 | -3.7 | 5.9 | 3.0e-09 | -0.26 | 1.00 | 0.00 | TRUE |
| 30 | METSIM | Adipose | RERE | 0.08 | 0.12 | lasso | 17 | 0.13 | 1.8e-19 | 8.8 | 9.9 | 5.3e-23 | 0.09 | 0.73 | 0.27 | FALSE |
| 31 | NTR | Blood | H6PD | 0.10 | 0.08 | bslmm | 435 | 0.08 | 3.1e-23 | -4.9 | 5.9 | 3.6e-09 | -0.09 | 1.00 | 0.00 | FALSE |
| 32 | NTR | Blood | RERE | 0.04 | 0.04 | lasso | 8 | 0.03 | 2.0e-11 | -9.4 | 9.6 | 8.3e-22 | 0.05 | 0.11 | 0.89 | FALSE |
| 33 | ROSMAP | Brain Pre-frontal Cortex | RERE | 0.15 | 0.15 | lasso | 7 | 0.15 | 1.5e-18 | 8.6 | 9.2 | 2.9e-20 | 0.10 | 1.00 | 0.00 | FALSE |
| 34 | ROSMAP | Brain Pre-frontal Cortex | PIK3CD | 0.25 | 0.23 | lasso | 3 | 0.24 | 9.0e-30 | -4.8 | -5.3 | 1.3e-07 | 0.54 | 1.00 | 0.00 | FALSE |
| 35 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | -11.1 | 11.1 | 1.1e-28 | 0.03 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H6PD | 0.08 | 0.07 | blup | 64 | 0.08 | 3.1e-15 | -4.9 | 6.5 | 6.6e-11 | -0.10 | 1.00 | 0.00 | FALSE |
| 37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -11.1 | 10.7 | 1.1e-26 | 0.03 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C1orf200 | 0.13 | 0.00 | blup | 30 | 0.00 | 1.8e-01 | -11.8 | 8.4 | 6.0e-17 | -0.74 | 0.00 | 0.71 | TRUE |
| 39 | The Cancer Genome Atlas | Colon Adenocarcinoma | H6PD | 0.08 | 0.01 | blup | 64 | 0.01 | 5.1e-02 | -4.8 | 7.6 | 3.1e-14 | -0.05 | 0.02 | 0.18 | FALSE |
| 40 | The Cancer Genome Atlas | Esophageal Carcinoma | RERE | 0.10 | 0.07 | blup | 154 | 0.06 | 5.2e-03 | -7.7 | 8.9 | 6.7e-19 | 0.02 | 0.02 | 0.71 | FALSE |
| 41 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H6PD | 0.05 | 0.01 | blup | 64 | 0.04 | 3.0e-05 | -4.8 | 6.5 | 5.8e-11 | -0.09 | 0.79 | 0.05 | FALSE |
| 42 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PIK3CD | 0.06 | 0.00 | enet | 5 | 0.02 | 2.4e-02 | -7.6 | -7.4 | 9.8e-14 | 0.65 | 0.02 | 0.40 | FALSE |
| 43 | The Cancer Genome Atlas | Lung Adenocarcinoma | H6PD | 0.04 | 0.01 | enet | 7 | 0.03 | 1.4e-04 | -4.8 | 6.9 | 6.3e-12 | -0.05 | 0.18 | 0.18 | FALSE |
| 44 | The Cancer Genome Atlas | Lung Adenocarcinoma | RERE | 0.06 | 0.01 | blup | 154 | 0.03 | 2.7e-04 | -11.1 | 8.7 | 3.5e-18 | 0.03 | 0.01 | 0.98 | FALSE |
| 45 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RERE | 0.04 | 0.02 | blup | 154 | 0.02 | 8.7e-04 | -9.4 | 8.2 | 2.0e-16 | 0.02 | 0.02 | 0.91 | FALSE |
| 46 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | H6PD | 0.07 | 0.04 | lasso | 5 | 0.03 | 2.8e-03 | -4.8 | 5.1 | 2.7e-07 | -0.06 | 0.13 | 0.06 | FALSE |
| 47 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | -11.1 | 10.6 | 2.1e-26 | 0.07 | 0.01 | 0.97 | FALSE |
| 48 | The Cancer Genome Atlas | Prostate Adenocarcinoma | H6PD | 0.15 | 0.15 | enet | 10 | 0.19 | 4.3e-19 | -4.8 | 7.0 | 1.9e-12 | -0.06 | 1.00 | 0.00 | FALSE |
| 49 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RERE | 0.04 | 0.01 | blup | 154 | 0.01 | 3.1e-02 | -3.8 | 7.0 | 2.1e-12 | -0.01 | 0.01 | 0.80 | FALSE |
| 50 | The Cancer Genome Atlas | Stomach Adenocarcinoma | H6PD | 0.08 | 0.07 | lasso | 4 | 0.05 | 2.5e-04 | -4.8 | 5.3 | 1.0e-07 | -0.06 | 0.14 | 0.69 | FALSE |
| 51 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | H6PD | 0.18 | 0.00 | enet | 11 | 0.05 | 9.3e-03 | -4.3 | 5.7 | 1.6e-08 | -0.06 | 0.01 | 0.05 | TRUE |
| 52 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RERE | 0.12 | 0.01 | enet | 10 | 0.03 | 4.6e-02 | -9.0 | 8.7 | 3.6e-18 | 0.01 | 0.03 | 0.65 | FALSE |