TWAS hub - PIK3CD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2270	0.0400	2.1e-14	0.187	0.127	0.182	0.081	0.087	3.5e-22	3.6e-15	1.3e-21	4.2e-10	9.5e-11
2	ROSMAP	Brain Pre-frontal Cortex	0.2465	0.0368	0.0e+00	0.234	0.190	0.233	0.226	0.235	1.1e-29	7.7e-24	1.4e-29	1.3e-28	9.0e-30
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0630	0.0350	6.1e-03	0.002	0.011	0.020	NA	0.018	2.4e-01	7.0e-02	2.4e-02	NA	3.1e-02
4	TCGA	Prostate Adenocarcinoma	0.0806	0.0408	3.2e-03	-0.002	0.024	0.008	NA	0.006	6.9e-01	1.4e-03	4.3e-02	NA	6.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Worry (Nagel 2018)	4.7	9.8	15.2	3.2	3.9	2.1	3.0
Blood Eosinophil Count	4.5	34.4	55.4	-7.2	-5.3	-7.4	-1.8
Worrier / anxious feelings	3.8	7.1	12.0	2.8	3.5	2.1	1.9
Chronic bronchitis/emphysema (father)	3.6	4.2	7.5	-1.7	-1.2	-2.7	-2.2
Nervous feelings	3.6	6.8	9.8	2.6	3.1	1.1	3.1
Blood White Count	3.2	23.6	42.8	-5.4	-4.5	-6.5	-1.5
Relative age voice broke	3.1	4.7	5.4	2.3	2.3	1.9	2.2
Ever had hysterectomy (womb removed)	2.9	3.3	4.3	-2.1	-1.8	-1.7	-1.6
Tense / ‘highly strung’	2.5	4.1	7.9	2.2	2.8	0.7	1.8
Blood clot in the leg (DVT)	2.5	3.3	5.0	2.2	2.0	2.0	-0.1
Qualifications: CSEs or equivalent	2.4	3.2	4.9	2.1	2.2	-0.2	1.8
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	6.1	-1.7	-1.6	-0.9	-2.5
Neuroticism score	2.3	4.7	9.6	2.5	3.1	1.5	0.9
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.6	-2.1	-1.3	-1.7	-1.1
Alcohol drinker status: Never	2.2	2.7	3.3	1.4	1.7	1.8	-1.6
Ever used hormone-replacement therapy (HRT)	2.1	2.7	4.8	-1.7	-1.7	-2.2	0.1
Knee pain experienced in last month	2.1	3.2	4.6	-1.9	-1.5	-1.5	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	5.9	2.2	2.4	2.0	1.6
Neuroticism (Nagel 2018)	2.0	4.6	8.8	2.5	3.0	1.5	1.0
Average weekly fortified wine intake	2.0	2.4	3.6	1.8	1.6	1.9	-0.0
Trunk fat-free mass	2.0	11.2	14.9	3.9	3.7	3.7	1.6
Trunk predicted mass	2.0	11.3	14.8	3.9	3.7	3.8	1.6
Length of working week for main job	2.0	2.2	3.5	1.9	1.8	0.7	1.1
Headache pain in last month	2.0	3.5	6.1	2.4	2.5	0.9	1.1
Medication: Ibuprofen	2.0	2.4	5.2	-1.5	-1.3	-0.7	-2.3
Had major operations	2.0	2.3	5.6	-1.1	-1.6	-2.4	0.1
Ever depressed for a whole week	2.0	2.5	3.7	1.7	1.9	1.2	-1.3
Diabetes (father)	1.9	2.3	3.5	-1.9	-1.8	-1.5	-0.7
Miserableness	1.9	3.3	5.9	2.1	2.4	1.6	0.4
HbA1C	1.8	2.0	2.9	1.2	1.6	1.7	1.0
Respiratory disease	1.8	4.0	6.1	-2.5	-2.0	-2.1	-1.4
Average weekly spirits intake	1.8	2.2	6.0	-1.4	-0.9	-2.5	-0.1
Prospective memory result	1.8	2.2	3.5	1.6	1.5	-0.6	1.9
Migraine (self-reported)	1.8	2.2	3.3	1.6	1.0	1.5	1.8
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	3.8	2.0	1.8	1.5	-0.2
Breast Cancer	1.7	4.1	5.0	-2.1	-2.2	-2.2	1.5
Angina	1.7	2.2	4.7	2.2	1.8	0.9	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	6.2	1.5	2.5	0.8	-1.3
Arm predicted mass (right)	1.7	8.4	12.3	3.5	3.2	3.0	1.5
Whole body water mass	1.7	9.7	13.8	3.7	3.5	3.4	1.1
Mother’s age at death	1.7	2.1	6.0	1.4	0.8	0.3	2.4
Number of operations (self-reported)	1.7	2.5	6.5	-1.0	-0.8	-2.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.6	-1.6	-1.5	-1.0	-1.2
Birth weight of first child	1.6	2.9	4.8	2.2	1.9	1.8	0.3
Angina (self-reported)	1.6	2.1	4.6	2.1	1.9	0.6	0.0
Suffer from ‘nerves’	1.6	2.5	4.1	1.5	2.0	0.6	1.9
Whole body fat-free mass	1.6	9.1	13.1	3.6	3.4	3.2	1.1
Asthma (self-reported)	1.6	3.2	5.2	-2.3	-1.8	-1.8	-1.0
Medication: Gliclazide	1.6	1.8	3.5	1.5	1.1	-0.2	1.9
Guilty feelings	1.6	2.4	4.8	1.9	2.2	0.6	-0.9
Qualifications: College or University degree	1.5	4.7	10.1	2.1	2.0	3.2	-0.0
Hearing aid user	1.5	1.7	2.6	-1.5	-1.6	-0.8	-1.2
Schizophrenia vs Biploar Disorder	1.4	1.8	3.5	-1.7	-1.9	-0.5	-0.9
Neuroticism	1.4	3.3	6.7	1.9	2.6	1.1	1.4
Medication: Co-codamol	1.4	1.6	3.5	-1.2	-1.1	-1.9	-0.2
Qualifications: A levels/AS levels or equivalent	1.4	3.1	6.5	1.4	1.8	2.5	0.9
Arm fat-free mass (right)	1.4	7.4	11.0	3.3	2.9	2.9	1.3
Number of children fathered	1.4	1.6	2.4	-1.2	-1.3	-0.8	-1.6
Medication for pain relief, constipation, heartburn	1.4	2.3	3.8	1.1	1.0	1.9	1.8
Eye problems/disorders: Cataract	1.4	1.6	4.0	2.0	1.4	0.6	0.3
Had other major operations	1.3	1.6	3.4	-0.2	0.1	-1.6	-1.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.9	0.2	0.5	1.5	2.4
Friendships satisfaction	1.3	1.6	3.0	1.7	1.7	0.8	0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.8	2.9	1.7	1.2	0.7	1.5
Basal metabolic rate	1.3	7.0	10.8	3.3	3.0	2.8	0.7
Arm predicted mass (left)	1.3	6.6	10.0	3.2	2.9	2.5	1.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.7	1.3	1.9	-0.0	-1.2
Leg fat-free mass (left)	1.2	6.4	10.1	3.2	2.9	2.6	0.3
Leg predicted mass (left)	1.2	6.4	10.0	3.2	2.9	2.7	0.3
Medication: Amlodipine	1.2	1.6	5.3	-0.6	-0.6	-2.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	2.6	1.3	1.6	0.8	1.0
Leg fat-free mass (right)	1.2	6.6	9.7	3.1	2.9	2.8	0.2
Leg predicted mass (right)	1.2	6.6	9.8	3.1	2.9	2.9	0.2
Medication: Blood pressure	1.2	2.3	3.1	-1.8	-1.5	-1.3	-1.4
Medication: Atorvastatin	1.2	1.4	3.0	-0.4	-0.7	-1.7	-1.5
Crohns Disease (2012)	1.1	1.8	3.5	-1.0	-1.1	-1.2	-1.9
Fasting Glucose	1.1	1.4	3.0	-1.1	-1.0	-1.7	0.4
Allergy or Eczema	1.1	3.0	4.2	-2.1	-1.4	-1.9	-1.4
Medication: Metformin	1.1	1.6	2.5	1.6	1.5	1.3	0.2
Diabetes (mother)	1.1	1.4	1.8	-1.1	-0.8	-1.3	1.3
Sitting height	1.1	7.9	12.5	2.8	2.6	3.5	2.1
High blood pressure (mother)	1.1	1.5	2.7	-1.4	-0.9	-1.6	-0.7
Qualifications: None of the above	1.1	2.5	4.8	-1.6	-1.5	-2.2	-0.4
Mouth/teeth dental problems	1.1	1.6	2.8	-1.4	-1.3	-1.7	0.1
Asthma	1.1	2.2	4.0	-2.0	-1.5	-1.3	-0.8
Standing height	1.1	11.3	18.8	3.6	3.5	4.3	1.3
Peak expiratory flow (PEF)	1.1	2.6	4.6	1.4	1.1	2.1	1.6
Age at last live birth	1.1	1.6	3.1	-1.8	-1.6	-0.7	-0.6
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.0	-0.4	-1.2	-1.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.7	-1.1	-0.6	-1.6	0.3
Qualifications: nursing, teaching	1.1	1.7	5.5	0.7	0.3	0.9	2.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.2	1.4	1.5	1.3	1.0
Osteoporosis (self-reported)	1.1	1.3	2.8	-0.8	-1.4	-0.4	-1.7
Arm fat-free mass (left)	1.1	5.8	8.9	3.0	2.8	2.2	1.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.2	-0.6	-0.6	-2.0	0.6
Supplements: Zinc	1.0	1.1	2.1	1.5	1.5	0.3	0.2
Severe depression (siblings)	1.0	1.1	3.8	-0.1	-0.3	-0.7	-1.9
Serious illness, injury or assault to yourself	1.0	1.2	2.8	0.4	0.1	1.3	-1.7
Fluid intelligence score	1.0	2.2	5.1	0.0	-0.0	1.9	-2.3
Pulse rate	1.0	1.6	3.0	1.2	1.4	-0.4	1.7
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.7	0.6	0.7	0.3	-1.9
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.7	-1.1	-1.0	-1.3	-1.0
Leg pain on walking	1.0	1.3	4.5	0.5	0.6	0.0	-2.1
Illnesses of father: None of the above (group 1)	1.0	1.2	2.5	0.8	1.0	1.6	-0.9
Unable to work because of sickness or disability	1.0	1.3	3.1	1.3	0.8	-0.3	-1.8
Depression (Nagel 2018)	0.9	1.4	2.5	1.3	1.6	0.6	-0.9
Coronary Artery Disease (CAD)	0.9	1.1	1.3	-1.0	-1.1	-0.9	-1.2
Chronotype (morning person)	0.9	2.1	6.1	-0.9	-1.0	-2.5	-0.8
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.9	0.6	0.7	1.5
Hand grip strength (right)	0.9	2.3	7.3	0.6	0.7	2.7	1.1
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	-1.6	-1.1	-1.9	-0.7
Multivitamins +/- minerals	0.9	1.2	2.5	1.6	1.1	0.9	-0.1
Medication: Atenolol	0.9	1.1	2.3	-0.1	-0.6	-1.5	-1.3
Number of incorrect matches in round	0.9	1.5	2.9	-1.7	-1.3	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	0.8	0.8	0.1	-1.8
Allergy	0.9	2.0	2.9	1.3	0.9	1.6	1.7
Depression (self-reported)	0.9	1.1	2.6	-0.6	-0.7	-0.8	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.5	1.3	1.6	-0.0	-0.7
Wheeze or whistling in the chest in last year	0.9	1.6	4.7	-0.8	-0.5	-1.0	-2.2
Neck or shoulder pain in last month	0.9	1.3	4.9	-0.3	-0.2	-0.3	-2.2
Medication: Blood pressure	0.9	1.6	4.0	-0.9	-1.3	-2.0	0.1
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.5	1.1	0.5	1.1	1.2
Wears glasses or contact lenses	0.9	1.0	2.7	0.6	0.6	1.6	0.7
Ever smoked	0.9	1.6	3.0	-1.5	-1.1	-1.7	-0.1
Commuting to job workplace: Cycle	0.9	1.1	1.7	0.8	1.2	1.3	0.8
Prostate Cancer	0.8	1.1	2.9	-0.9	-0.6	-1.7	-0.4
Lung FVC	0.8	3.9	5.2	-2.0	-1.9	-2.3	1.7
Relative age of first facial hair	0.8	1.7	3.2	1.1	1.1	1.1	1.8
Vitamin and mineral supplements	0.8	1.1	2.2	-1.5	-1.3	-0.5	-0.5
Fed-up feelings	0.8	1.5	2.5	1.5	1.6	1.0	-0.3
High blood pressure	0.8	2.3	3.2	-1.4	-1.8	-1.5	-1.4
Medication: Levothyroxine sodium	0.8	1.3	2.8	-0.5	-0.5	-1.7	-1.4
Health satisfaction	0.8	1.0	2.0	0.9	0.7	-0.8	-1.4
Shortness of breath walking on level ground	0.8	0.9	1.3	1.1	1.1	-0.2	-1.1
Emphysema/chronic bronchitis	0.8	0.9	1.8	-0.2	0.0	-1.3	-1.4
Medication: Allopurinol	0.8	1.1	2.0	1.4	1.4	0.7	-0.3
Medication: Omeprazole	0.8	0.9	3.1	-0.5	-0.3	-1.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.7	1.1	1.3	0.8	0.2
Hypertension (Self-reported)	0.8	2.2	3.0	-1.4	-1.7	-1.7	-1.1
Ever taken oral contraceptive pill	0.8	0.9	1.7	0.7	0.8	0.8	1.3
Depressed Affect (Nagel 2018)	0.7	1.6	2.8	1.5	1.7	1.0	0.0
Reaction Time	0.7	1.3	3.3	1.2	1.8	-0.1	0.8
Smoking Status	0.7	1.7	2.6	-1.5	-1.6	-1.4	-0.1
Cardiovascular Disease	0.7	2.3	3.2	-1.7	-1.8	-1.6	-0.8
Hearing difficulty/problems: Yes	0.7	1.1	2.3	-1.1	-0.7	-0.8	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.1	0.7	1.0	-1.1	-0.9
Financial difficulties in last 2 years	0.7	1.0	1.3	-1.1	-0.6	-1.1	-1.1
Father’s age at death	0.7	0.9	2.0	-0.7	-0.8	-0.6	-1.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.3	0.5	0.8	0.2	-1.5
Worry too long after embarrassment	0.7	1.1	2.8	1.0	1.7	0.6	0.5
Heart disease (mother)	0.7	0.8	2.6	0.5	0.2	0.6	-1.6
Pulse rate, automated reading	0.7	2.4	4.8	1.5	1.5	0.7	2.2
Alcohol intake frequency.	0.7	1.7	3.5	1.1	1.1	1.0	-1.9
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.5	1.0	1.2	0.4	0.9
Commuting to job workplace: Public transport	0.7	0.8	2.4	0.3	0.5	0.6	-1.6
Medication: Lisinopril	0.7	0.9	1.8	-0.9	-1.0	-1.4	-0.1
Fractured/broken bones in last 5 years	0.7	0.9	1.5	1.2	0.7	1.1	0.7
Vascular/heart problems diagnosed by doctor	0.7	1.8	2.7	1.0	1.3	1.6	1.3
Cholesterol lowering medication	0.7	1.0	2.1	-0.5	-0.7	-1.0	1.4
Blood Platelet Count	0.6	6.4	8.2	-2.9	-2.6	-2.5	2.1
Height	0.6	11.8	15.8	4.0	3.8	3.9	1.2
Weight	0.6	2.8	5.7	2.4	1.8	1.4	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	1.6	0.6	0.9	0.9	-1.3
Medication: Lansoprazole	0.6	0.7	1.3	1.2	0.5	0.7	0.9
Exposure to tobacco smoke at home	0.6	0.7	1.5	1.2	0.7	0.5	-0.8
Pulse wave reflection index	0.6	0.7	1.8	0.6	0.6	-0.4	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.7	0.6	1.2	1.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.1	-0.3	-0.4	-2.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	0.9	-0.9	-0.8	-0.9	-0.9
Average weekly red wine intake	0.6	0.9	1.6	0.6	0.8	1.3	1.0
Diabetes diagnosed by doctor	0.6	1.0	1.9	1.4	1.1	-0.2	-1.0
Back pain experienced in last month	0.6	0.8	2.6	0.5	0.6	-0.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.9	0.1	0.4	0.2	2.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	1.0	1.2	0.4	0.2
Bipolar Disorder (2018)	0.5	0.8	1.6	1.3	0.8	1.0	-0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.9	-0.7	-0.4	1.2	-1.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	0.8	0.9	1.2	0.4
Rheumatoid Arthritis	0.5	0.6	0.9	-0.9	-0.9	-1.0	-0.1
Ulcerative Colitis	0.5	0.8	1.4	1.1	1.2	0.4	0.5
Lung FEV1/FVC ratio	0.5	2.8	5.6	2.4	1.7	1.4	-0.8
Hand grip strength (left)	0.5	1.3	2.7	0.2	0.2	1.6	1.6
Number of treatments/medications taken	0.5	0.8	2.6	-0.2	-0.5	-1.6	-0.7
Systolic blood pressure, automated reading	0.5	1.5	2.8	-1.3	-1.7	-1.1	0.5
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.5	-0.8	-0.9	-0.7
Taking other prescription medications	0.5	0.8	2.2	-0.0	-0.3	-1.5	-1.0
Impedance of leg (left)	0.5	2.7	4.1	-2.0	-1.8	-1.7	0.6
Past tobacco smoking	0.5	0.9	1.4	1.2	0.9	1.2	-0.3
Medication: Simvastatin	0.5	0.7	1.4	0.6	-0.1	1.2	1.1
Noisy workplace	0.5	0.6	1.1	1.1	1.0	-0.4	-0.4
Medication: Cholesterol lowering	0.5	0.7	1.3	-0.4	-1.2	-0.4	-1.1
Breastfed as a baby	0.5	0.6	1.3	1.2	0.7	0.8	0.1
Pulse wave peak to peak time	0.5	0.5	2.1	-0.3	0.1	1.4	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-0.1	0.2	1.3	0.7
Overall health rating	0.5	1.1	2.9	0.7	0.8	-0.7	-1.7
Loneliness, isolation	0.5	0.6	1.8	0.9	1.3	-0.2	0.2
Medication: Aspirin	0.5	0.7	2.1	-0.3	-0.6	-1.5	0.3
Smoking status: Current	0.5	0.8	1.3	-0.7	-0.9	-0.8	-1.1
Financial situation satisfaction	0.5	0.6	1.0	1.0	1.0	-0.7	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	0.5	0.5	0.9	1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.0	-0.8	-0.5	-1.0	-0.1
Crohns Disease (2017)	0.4	0.9	3.2	0.5	0.5	-0.2	-1.8
Ulcerative Colitis (UC)	0.4	0.7	1.1	0.9	1.0	0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.7	-0.1	1.0	-0.7
Impedance of leg (right)	0.4	2.2	2.9	-1.7	-1.5	-1.5	1.1
Current tobacco smoking	0.4	0.6	1.8	-0.5	-0.6	-0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.2	1.0	0.2	1.5	-0.3
Hearing difficulty/problems with background noise	0.4	0.6	1.2	0.5	0.6	0.7	-1.1
Impedance of arm (right)	0.4	1.8	2.5	-1.6	-1.3	-1.2	-1.3
Arm fat percentage (right)	0.4	1.5	3.3	0.0	-0.4	-1.8	-1.6
Number of live births	0.4	0.5	1.8	0.1	0.2	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.4	0.6	0.6	1.5	1.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-1.2	-0.9	-0.4	-0.6
Illnesses of mother	0.4	0.5	1.4	0.2	0.3	1.2	0.8
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	0.4	-0.0	-1.3	0.2
Loud music exposure frequency	0.4	0.4	0.9	-1.0	-0.6	-0.6	-0.3
Leg fat percentage (right)	0.4	1.4	5.0	-0.3	-0.7	-2.2	-0.3
Comparative body size at age 10	0.4	1.0	2.3	0.4	0.5	1.1	-1.5
Number of full sisters	0.4	0.5	1.0	1.0	0.8	0.2	-0.6
Family relationship satisfaction	0.4	0.5	0.7	0.6	0.8	-0.4	-0.8
Long-standing illness, disability or infirmity	0.4	0.7	2.2	0.1	0.1	-0.7	-1.5
Illnesses of father: High blood pressure	0.4	0.5	0.7	-0.6	-0.9	-0.8	-0.3
Leg fat percentage (left)	0.4	1.6	4.9	-0.5	-0.8	-2.2	-0.7
Risk taking	0.4	0.6	1.1	1.1	1.0	0.3	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.5	-0.3	0.1	-0.1	-1.2
Myopia	0.4	0.6	1.7	0.3	0.3	1.3	0.6
Pain experienced in last month	0.4	0.7	1.6	-0.3	-0.3	1.0	1.3
Supplements: Calcium	0.4	0.4	0.6	0.6	0.7	0.8	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	0.8	0.1	1.2	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.1	0.2	0.5	1.8	-0.6
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.4	-0.2	-0.9	-0.6
Ovarian Cancer	0.3	0.5	1.3	-0.2	-0.3	0.6	-1.1
Age at First Birth	0.3	0.5	0.9	0.7	1.0	0.4	0.5
HDL Cholesterol	0.3	0.5	1.7	-0.3	-0.2	-0.3	-1.3
Triglycerides	0.3	0.5	1.4	-0.7	-0.5	0.2	-1.2
Heel T-Score	0.3	2.1	3.2	-1.3	-1.6	-0.8	-1.8
Systolic Blood Pressure	0.3	1.6	2.7	-1.5	-1.6	-1.0	0.6
Hypothyroidism (self reported)	0.3	0.6	2.0	-0.2	-0.3	-1.4	-0.5
Pain all over the body in last month	0.3	0.3	0.5	-0.5	-0.7	-0.6	0.1
Diabetes (self-reported)	0.3	0.5	1.3	1.1	0.9	0.1	-0.1
Medication: Ramipril	0.3	0.4	0.8	0.3	0.1	0.8	-0.9
Happiness	0.3	0.4	0.7	0.7	0.4	-0.3	-0.8
Lung cancer (father)	0.3	0.4	1.1	0.5	1.0	0.2	0.5
Impedance of arm (left)	0.3	1.2	1.8	-1.2	-1.0	-0.7	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.8	0.7	0.4	-0.7
Body fat percentage	0.3	1.1	2.7	0.2	-0.3	-1.6	-1.2
Eye problems/disorders: None of the above	0.3	0.3	0.9	-1.0	-0.6	-0.3	0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.3	0.4	-0.6	0.8
Comparative height size at age 10	0.3	1.9	2.5	1.6	1.5	1.2	1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	0.2	0.0	0.6	0.9
Medication: Aspirin	0.3	0.4	1.2	-0.5	-0.6	-1.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.8	0.6	0.6	-0.3
Illnesses of father: Heart disease	0.3	0.5	1.0	0.7	0.6	-0.2	1.0
Illnesses of siblings: Diabetes	0.3	0.3	0.7	0.6	0.8	0.6	0.2
Smoking status: Previous	0.3	0.4	0.6	-0.7	-0.4	-0.6	0.8
Arm fat percentage (left)	0.3	1.3	2.6	0.3	-0.1	-1.6	-1.6
Medication for cholesterol	0.3	0.4	0.6	0.8	0.8	0.5	0.3
Breast cancer (self-reported)	0.3	0.3	0.9	0.5	0.9	-0.2	0.3
Osteoarthritis (self-reported)	0.3	0.3	0.7	-0.3	-0.6	-0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.8	1.0	-0.1	0.0
Medication: Bendroflumethiazide	0.3	0.4	0.7	-0.3	-0.6	-0.8	0.6
Medication: Paracetamol	0.3	0.4	1.0	0.3	0.4	-1.0	-0.6
Diastolic blood pressure, automated reading	0.3	0.8	1.5	-1.2	-1.2	-0.7	0.2
Alcohol drinker status: Previous	0.3	0.3	0.7	0.8	0.9	-0.2	0.1
Impedance of whole body	0.3	1.5	2.4	-1.6	-1.3	-1.3	-0.3
Schizophrenia (2018)	0.2	0.4	0.8	0.1	-0.5	0.9	-0.8
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.8	0.8	0.2	-0.7
Mean Putamen Volume	0.2	0.3	0.5	-0.4	-0.7	0.1	0.6
Neuroticism (2016)	0.2	0.3	0.5	0.7	0.7	0.4	-0.2
Schizophrenia (2014)	0.2	0.4	1.2	-0.3	-0.6	0.2	-1.1
Waist Hip Ratio (WHR)	0.2	0.9	1.7	-1.3	-0.7	-1.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.8	0.5	0.4	-0.8	-0.9
Sensitivity / hurt feelings	0.2	0.3	0.6	0.8	0.6	0.5	-0.1
Trunk fat percentage	0.2	1.0	2.2	0.2	-0.3	-1.5	-1.3
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.5	-0.4	-0.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.3	0.3	0.6	0.5
Supplements: Glucosamine	0.2	0.3	0.7	0.6	-0.1	0.1	-0.8
Trunk fat mass	0.2	0.7	1.6	1.3	0.8	-0.3	-0.7
Alcohol usually taken with meals	0.2	0.3	0.8	-0.5	-0.5	-0.1	0.9
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.2	-0.8	-0.5	-0.4
Forced vital capacity (FVC)	0.2	0.9	1.8	0.5	0.6	1.1	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	0.7	0.0	-0.8	0.9	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.7	0.6	0.6	-0.0
Time employed in main current job	0.2	0.2	0.3	0.5	-0.4	-0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.5	0.6	0.7	-0.7	-0.4
Arm fat mass (right)	0.2	0.7	1.3	0.7	0.3	-0.9	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.3	-0.2	-0.1	-0.9
Medication: Paracetamol	0.2	0.4	1.2	0.2	0.1	-0.6	-1.1
Glaucoma (self-reported)	0.2	0.2	0.7	-0.3	-0.2	0.8	0.4
Age at first live birth	0.2	0.4	0.8	-0.9	-0.6	0.2	0.5
Mean time to correctly identify matches	0.2	0.3	0.8	0.5	0.9	-0.5	0.0
Whole body fat mass	0.2	0.6	1.3	1.1	0.6	-0.6	-0.8
Chest pain or discomfort	0.2	0.4	1.0	-0.1	0.1	-0.7	-1.0
Mood swings	0.2	0.4	1.0	1.0	0.7	-0.5	0.1
Commuting to job workplace: Walk	0.2	0.2	0.5	0.0	0.4	0.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.7	0.5	0.0	0.3
Arm fat mass (left)	0.2	0.8	1.2	1.0	0.6	-0.8	-1.1
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.2	-0.6	0.2	0.8
Age started oral contraceptive pill	0.2	0.3	1.0	0.1	-0.4	0.1	1.0
Heart disease (siblings)	0.2	0.2	0.5	0.1	0.0	0.7	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.0	0.2	-0.8	-0.3
Lupus	0.1	0.2	0.4	-0.2	-0.0	-0.6	-0.6
Blood Red Count	0.1	1.1	3.2	-0.3	-0.9	-0.5	-1.8
BMI	0.1	0.6	0.9	1.0	0.8	-0.5	-0.9
Hair Pigment	0.1	3.2	5.4	1.4	1.9	1.4	2.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.2	-0.1	0.6	-0.0
Pack years adult smoking proportion	0.1	0.1	0.3	0.3	0.5	-0.2	-0.5
Maternal smoking around birth	0.1	0.2	0.6	0.4	0.7	-0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.3	0.2	0.6	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.5
Body mass index (BMI)	0.1	0.5	1.0	0.7	0.2	-0.7	-1.0
Waist circumference	0.1	0.3	0.7	0.2	-0.2	-0.8	-0.6
Heart attack	0.1	0.1	0.4	0.6	0.3	-0.3	0.1
Hip circumference	0.1	0.3	0.6	0.8	0.1	0.1	-0.7
Falls in the last year	0.1	0.2	0.4	0.6	0.2	0.4	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	-0.0	0.7	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	-0.3	-0.1	0.4	0.9
Hair/balding pattern: Pattern 4	0.1	0.1	0.5	0.1	-0.0	-0.2	-0.7
Gout (self-reported)	0.1	0.2	0.4	0.2	0.1	0.3	-0.7
Birth weight	0.1	0.2	0.3	0.4	0.2	0.3	0.5
High blood pressure (siblings)	0.1	0.1	0.4	-0.2	-0.0	-0.6	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	1.2	-0.5	-0.2	-0.0	1.1
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.2	0.4	-0.6	-0.3
Number of full brothers	0.1	0.2	0.5	-0.0	0.4	0.0	0.7
Leg fat mass (right)	0.1	0.4	0.7	0.8	0.4	-0.8	-0.3
Supplements: Vitamin C	0.1	0.1	0.1	0.3	0.2	-0.3	0.1
Ever had bowel cancer screening	0.1	0.1	0.2	0.2	0.0	0.1	0.4
Mineral and other dietary supplements	0.1	0.1	0.5	-0.3	-0.1	0.7	-0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.5	0.1	-0.6	-0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.3	-0.6	-0.4	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.5	0.0	-0.2	0.7	0.0
Irritability	0.1	0.2	0.6	0.1	0.2	0.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.5	0.1	-0.2	0.1
Pack years of smoking	0.1	0.2	0.3	0.3	0.5	-0.2	-0.5
Leg fat mass (left)	0.1	0.4	0.7	0.7	0.3	-0.9	-0.6
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.1	0.0	-0.2	0.4
Tanning	0.0	0.5	1.8	0.2	-0.3	-0.1	-1.4
Age when periods started (menarche)	0.0	0.1	0.2	-0.0	0.0	0.3	0.5
Had menopause	0.0	0.1	0.2	-0.1	-0.0	-0.3	-0.4
Illnesses of siblings	0.0	0.0	0.1	0.1	-0.2	0.2	0.3

Hub : Genes

PIK3CD

Models

Trait associations