Hub : Genes

RBP7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0480 0.0230 8.6e-03 0.002 0.016 0.005 0.017 0.003 1.5e-01 4.1e-03 7.6e-02 2.9e-03 1.3e-01
2 GTEx Testis 0.6300 0.0710 5.4e-11 0.075 NA 0.278 NA 0.219 3.3e-04 NA 9.4e-13 NA 4.5e-10
3 GTEx Thyroid 0.1270 0.0520 1.9e-03 -0.001 NA 0.008 NA -0.003 4.3e-01 NA 6.8e-02 NA 7.4e-01
4 GTEx Whole Blood 0.0640 0.0360 2.3e-03 0.005 NA 0.024 NA 0.012 1.1e-01 NA 2.3e-03 NA 2.3e-02
5 METSIM Adipose 0.1351 0.0512 2.0e-03 0.066 0.009 0.070 0.068 0.055 3.6e-10 1.2e-02 1.0e-10 2.2e-10 1.1e-08
6 NTR Blood 0.0184 0.0084 3.1e-03 0.021 0.006 0.015 0.011 0.019 1.3e-07 3.5e-03 1.0e-05 1.3e-04 4.7e-07
7 ROSMAP Brain Pre-frontal Cortex 0.0826 0.0346 2.0e-03 0.000 0.009 0.002 0.014 0.004 3.1e-01 2.0e-02 1.7e-01 4.9e-03 9.6e-02
8 YFS Blood 0.0830 0.0218 0.0e+00 0.090 0.073 0.085 0.086 0.087 6.1e-28 1.1e-22 2.8e-26 1.2e-26 5.0e-27
9 TCGA Kidney Renal Clear Cell Carcinoma 0.1487 0.0532 2.5e-05 0.058 0.048 0.059 NA 0.057 3.7e-07 3.8e-06 3.0e-07 NA 5.4e-07
10 TCGA Brain Lower Grade Glioma 0.0702 0.0331 2.0e-03 0.034 0.030 0.042 NA 0.038 7.8e-05 2.0e-04 1.2e-05 NA 3.7e-05
11 TCGA Thyroid Carcinoma 0.1530 0.0550 2.6e-06 0.026 0.077 0.064 NA 0.070 1.4e-03 5.4e-08 7.0e-07 NA 2.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.9 1.4 7.1 -1.3 0.6 0.0 0.1 -2.7 -1.4 -1.4 -1.6 0.0 0.0 -0.1
Bipolar Disorder or Schizophrenia 0.4 0.9 5.0 -1.1 0.3 0.0 -0.2 -2.2 -0.3 -1.8 -0.6 0.0 0.0 -0.1
Depressed Affect (Nagel 2018) 0.4 0.8 4.2 -2.0 0.6 0.0 -0.1 -0.2 -0.4 -0.1 -0.7 -0.8 -0.6 -1.5
Depression (Nagel 2018) 0.9 1.3 4.7 -0.7 -0.1 0.0 0.9 -1.4 1.1 -0.7 0.7 -1.5 -1.4 -2.2
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.5 0.2 0.3 0.0 -0.1 -1.2 -0.1 -0.6 0.7 -1.2 -1.0 -0.8
Neuroticism (Nagel 2018) 0.5 1.2 5.8 -2.4 1.0 0.0 0.6 -0.7 -0.5 0.5 -0.8 -0.8 -0.9 -1.8
Schizophrenia (2018) 0.1 0.3 1.4 -0.4 -0.0 0.0 -0.5 -0.9 0.7 -1.2 0.6 0.0 0.0 -0.1
Schizophrenia vs Biploar Disorder 1.1 1.4 5.5 1.3 -0.9 0.0 0.4 2.3 1.1 1.7 1.6 0.0 0.0 -0.9
Worry (Nagel 2018) 0.1 0.3 1.2 -1.1 0.6 0.0 -0.0 -0.4 0.8 0.8 0.4 0.3 0.2 -0.4
Alzheimer’s Disease (in mother) 0.3 0.3 1.5 -1.2 0.5 0.0 0.1 -0.4 -0.4 -0.6 -1.0 0.1 -0.2 -0.2
Alzheimer’s Disease (in father) 0.3 0.3 0.8 -0.0 -0.7 0.0 0.1 -0.9 0.8 -0.4 0.6 -0.7 -0.7 -0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 3.0 -1.7 0.1 0.0 -0.5 -1.1 -0.2 -1.3 -0.7 -0.2 -0.8 -0.5
Crohns Disease (2017) 0.3 0.7 2.6 -0.9 -0.2 0.0 -0.6 0.4 -0.2 -0.6 -0.0 1.2 1.2 1.6
Irritable Bowel Disease (IBD) 0.2 0.5 2.1 -1.3 -0.6 0.0 -0.4 -0.2 -0.1 0.3 0.4 0.6 0.8 1.4
Ulcerative Colitis (UC) 0.3 0.7 3.3 -1.8 -0.6 0.0 -0.2 -1.1 -0.5 0.9 -0.1 -0.8 -0.6 -0.2
Major Depression (MDD) 0.6 0.8 3.1 1.6 -0.6 0.0 -0.8 0.3 1.8 -0.7 1.1 0.0 0.0 0.2
Reaction Time 1.9 3.7 11.8 -0.3 -0.2 0.0 0.4 -3.2 -0.6 1.1 -0.8 -3.4 -3.4 -2.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 3.0 -1.3 1.3 0.0 -1.7 -0.1 -1.1 -1.0 -0.5 0.4 -0.0 -0.5
Breast Cancer 2.1 5.0 21.3 2.4 -1.4 0.0 -4.1 2.2 0.6 4.6 -0.5 1.7 1.1 0.9
Ovarian Cancer 0.3 0.5 2.6 -0.1 -0.4 0.0 -1.6 0.4 -0.0 0.7 -0.3 0.4 0.5 1.0
Prostate Cancer 1.6 2.2 7.3 -0.4 0.3 0.0 2.2 -1.4 1.5 -1.7 1.2 -1.8 -0.8 -2.7
Age at First Birth 0.4 0.5 2.8 1.7 -0.7 0.0 0.2 -0.2 0.8 -0.9 0.4 0.0 0.4 0.7
Bipolar Disorder (2011) 0.4 0.4 1.8 0.7 -0.9 0.0 1.3 0.0 1.0 -0.2 0.5 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 2.3 -1.1 0.3 0.0 0.9 -0.9 -1.0 -1.5 -1.1 -0.3 0.0 -0.1
Coronary Artery Disease (CAD) 0.2 0.3 1.5 -0.7 0.5 0.0 -0.9 -0.1 0.3 -1.2 -0.3 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 3.0 -1.4 -0.4 0.0 -0.6 -0.1 -0.3 -1.7 -0.2 0.0 0.0 0.6
Mean Putamen Volume 0.8 0.9 3.1 0.9 -0.8 0.0 1.3 -1.8 0.7 -0.2 0.7 -1.0 -1.2 -0.7
Fasting Glucose 0.3 0.4 1.7 -0.3 0.9 0.0 0.4 0.3 -0.3 -0.1 -0.6 -0.8 -0.3 -1.3
HbA1C 0.5 0.6 2.5 -0.4 -0.1 0.0 0.2 -1.6 0.6 -1.1 -0.0 1.1 0.0 0.7
HDL Cholesterol 0.4 0.7 2.0 -1.4 0.5 0.0 0.2 0.2 -0.7 -1.3 -0.7 -0.8 0.0 -1.4
LDL Cholesterol 0.2 0.3 0.9 -0.8 -0.5 0.0 0.3 -1.0 -0.1 -0.7 -0.2 -0.8 0.0 -0.3
Lupus 0.5 0.8 2.4 -1.1 -0.4 0.0 -1.3 -1.1 -0.8 -1.6 -0.4 -0.8 -0.9 -0.6
Neuroticism (2016) 0.1 0.2 1.2 -1.1 -0.4 0.0 -0.4 -0.4 0.3 -0.1 0.5 -0.1 -0.1 -0.0
Primary Biliary Cirrhosis 0.2 0.3 1.0 -0.1 -0.1 0.0 0.1 0.8 -0.2 0.1 -0.0 1.0 0.9 1.0
Rheumatoid Arthritis 0.2 0.3 1.4 0.8 -0.6 0.0 -0.2 -0.4 -0.2 1.2 0.0 -0.5 -0.4 0.3
Schizophrenia (2014) 0.1 0.3 1.4 -1.2 0.3 0.0 -0.5 -0.8 0.0 -0.7 -0.2 0.0 0.0 -0.6
Triglycerides 0.5 0.8 2.2 1.5 -1.5 0.0 -0.0 -0.0 0.5 1.5 0.7 -1.2 0.0 0.4
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.8 1.3 0.4 0.0 0.7 1.7 0.6 -0.3 0.1 0.0 0.0 -0.4
Ulcerative Colitis 0.5 0.7 2.5 -1.6 0.1 0.0 -0.4 -1.4 -1.1 1.2 -0.4 0.0 0.0 -0.3
Blood Eosinophil Count 0.9 6.6 35.2 0.2 -0.3 0.0 -2.3 5.9 -0.5 0.0 0.6 2.9 3.1 3.7
Blood Platelet Count 0.4 4.4 17.1 1.3 -0.3 0.0 -2.4 1.1 -0.2 -3.1 0.6 2.7 2.4 4.1
Blood Red Count 0.1 0.9 2.6 -0.6 0.0 0.0 0.3 1.6 0.6 1.4 0.5 1.2 1.4 1.0
Blood White Count 1.6 11.9 32.0 3.0 -2.6 0.0 3.4 2.7 5.2 -2.6 5.7 2.1 4.2 2.8
Heel T-Score 0.4 3.6 9.0 0.9 2.7 0.0 2.8 -0.6 -2.4 0.0 -1.2 -2.1 -1.6 -3.0
BMI 0.5 3.0 17.9 0.4 -0.5 0.0 4.2 -0.7 2.4 -0.8 2.0 -1.6 -0.4 -0.8
Height 0.7 13.8 48.0 -3.1 1.3 0.0 -6.9 -1.3 -5.3 6.2 -4.4 0.8 -1.6 1.5
Waist Hip Ratio (WHR) 0.9 4.2 8.9 2.4 -0.1 0.0 1.9 2.0 2.8 -0.6 2.3 2.3 3.0 2.2
Systolic Blood Pressure 0.6 3.0 11.0 1.0 -1.7 0.0 -3.3 1.8 1.2 0.8 1.1 2.1 2.0 1.7
Smoking Status 0.2 0.4 2.2 0.2 -1.5 0.0 -0.6 -0.1 0.8 1.0 0.1 -0.3 -0.2 0.1
Allergy or Eczema 0.3 0.8 2.8 0.9 0.7 0.0 1.7 0.5 1.0 -1.4 0.8 -0.4 0.3 -0.6
Cardiovascular Disease 0.8 2.5 8.8 1.9 -1.6 0.0 2.0 1.2 3.0 0.1 2.6 -0.6 0.6 -0.3
Hypothyroidism (self reported) 0.8 1.9 7.7 -0.6 1.2 0.0 2.8 -1.5 -1.0 -0.6 -1.0 -1.2 -1.6 -1.5
Respiratory disease 1.1 2.4 9.6 0.9 -0.1 0.0 1.6 3.1 1.4 0.1 1.7 1.1 2.4 1.3
Type 2 Diabetes (T2D) (2018) 1.1 2.1 8.3 0.3 -0.0 0.0 2.9 -0.9 2.0 -1.5 2.7 -0.8 -0.0 0.1
Lung FEV1/FVC ratio 0.7 3.4 20.8 -1.3 1.0 0.0 4.6 -0.8 -0.1 -1.4 -0.6 -1.6 -0.7 -2.8
Lung FVC 0.4 2.0 8.5 0.6 -0.9 0.0 -2.9 -1.0 -1.6 1.6 -2.3 0.2 -1.0 0.3
Neuroticism 0.2 0.5 2.6 -1.1 -0.2 0.0 0.7 -0.3 0.6 0.8 0.2 -0.7 -0.4 -1.6
Chronotype (morning person) 0.7 1.7 12.7 -1.6 -1.3 0.0 0.3 -0.7 0.3 -3.6 0.9 -0.3 0.0 0.4
Hair Pigment 0.1 3.1 9.0 0.1 1.2 0.0 -2.2 -1.0 -2.0 2.1 -3.0 -1.0 -2.2 -1.9
Tanning 0.1 1.3 5.8 0.5 -1.6 0.0 -1.5 0.4 -0.6 0.6 0.5 0.7 1.1 2.4
Hand grip strength (left) 1.5 3.9 15.2 -1.2 1.2 0.0 -3.9 -0.0 -2.9 1.5 -2.5 2.0 0.1 1.9
Number of treatments/medications taken 0.4 0.8 5.6 0.3 -0.4 0.0 2.4 0.3 0.5 -0.0 0.4 -1.3 -0.5 -0.8
Average weekly spirits intake 1.4 1.7 4.5 1.2 -1.5 0.0 0.8 -0.8 2.1 -0.9 1.9 -1.7 -1.2 -0.8
Sensitivity / hurt feelings 0.5 0.9 2.9 -0.9 0.4 0.0 0.8 -0.5 -0.8 0.6 -1.2 -1.1 -1.1 -1.7
Frequency of depressed mood in last 2 weeks 2.4 3.4 7.7 -0.0 -1.6 0.0 0.9 -2.6 2.0 -1.1 2.0 -2.8 -2.5 -2.0
Hearing difficulty/problems: Yes 1.0 1.6 3.9 -1.1 -0.9 0.0 -1.5 0.1 1.1 -2.0 1.4 1.8 1.6 0.5
Relative age of first facial hair 1.3 2.6 7.0 0.2 2.5 0.0 -1.4 0.4 -2.3 2.6 -2.5 0.0 -0.2 -1.2
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 10.2 2.3 -2.6 0.0 1.5 -0.1 2.8 0.6 3.2 -1.0 0.0 0.0
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.7 0.1 0.4 0.0 0.2 0.8 -0.6 -0.1 -0.4 0.3 -0.0 -0.4
Ever had hysterectomy (womb removed) 0.5 0.6 2.8 0.3 0.1 0.0 1.7 0.2 -0.3 -1.1 -0.3 -0.9 -0.5 -1.1
Systolic blood pressure, automated reading 0.8 2.4 9.9 0.2 -1.2 0.0 -3.1 1.5 0.6 -0.1 0.2 2.0 1.9 2.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 0.4 0.8 0.0 0.7 0.1 -0.5 -0.1 -0.3 -0.2 0.3 -0.6
Angina 0.4 0.5 1.0 -0.4 -1.0 0.0 0.9 -0.2 0.8 0.2 1.0 -1.0 -0.9 -0.1
Medication for hormone replacement therapy 0.6 0.7 2.9 -0.2 0.9 0.0 1.2 -0.3 -0.5 -0.8 -0.4 -0.7 -1.1 -1.7
Vitamin and mineral supplements 2.6 3.5 13.0 -0.2 1.0 0.0 -1.8 2.1 -0.4 1.6 -0.6 3.6 2.5 2.7
Supplements: Zinc 2.5 2.7 6.8 -0.1 -1.2 0.0 2.2 -2.3 1.3 -1.0 1.4 -2.6 -1.9 -1.8
Medication: Co-codamol 0.2 0.2 0.6 -0.4 -0.8 0.0 -0.5 -0.5 -0.1 -0.3 -0.4 0.2 0.1 0.7
Medication: Metformin 1.2 1.7 6.6 -0.4 0.9 0.0 2.6 0.6 1.3 -1.4 1.8 1.1 1.5 0.7
Diabetes (father) 0.3 0.4 0.9 -0.0 0.9 0.0 0.8 0.9 -0.4 -0.7 -0.4 0.5 0.9 0.5
Diabetes (mother) 0.6 0.7 3.2 1.0 -0.8 0.0 0.1 0.2 1.8 -1.1 1.4 -0.1 0.1 -0.1
Severe depression (siblings) 0.7 0.8 3.5 -0.8 -0.0 0.0 1.3 0.3 -0.6 -1.9 -1.1 -1.0 -0.3 -0.6
Pack years adult smoking proportion 0.6 0.9 2.8 -1.7 0.9 0.0 0.4 -0.5 -1.0 -0.7 -1.5 -0.1 -0.8 -1.2
Impedance of leg (right) 0.5 2.3 6.8 2.6 -1.0 0.0 0.7 2.5 0.5 2.6 0.4 0.4 1.7 1.0
Leg fat-free mass (left) 0.8 4.4 10.0 -2.8 1.6 0.0 -0.8 -3.2 -2.7 0.7 -2.2 -1.7 -3.0 -1.6
Trunk fat percentage 0.9 3.6 17.7 -0.5 0.2 0.0 4.2 -1.7 0.5 -0.4 0.4 -3.0 -1.8 -2.5
Hand grip strength (right) 1.9 5.1 21.3 -1.7 1.5 0.0 -4.6 -0.8 -3.5 1.4 -3.1 1.5 -0.9 1.4
Townsend deprivation index at recruitment 0.9 1.3 3.3 -1.1 -0.4 0.0 -0.3 -1.7 -0.9 -0.8 -1.4 -1.6 -1.8 -0.9
Current tobacco smoking 0.8 1.3 7.1 0.9 -2.7 0.0 0.3 -1.0 1.2 0.4 0.7 -1.3 -1.2 -0.5
Average weekly fortified wine intake 0.3 0.3 1.5 0.4 1.2 0.0 -0.6 -0.5 -0.3 -0.6 -0.7 0.6 0.0 -0.1
Maternal smoking around birth 0.8 1.1 5.3 -1.0 0.6 0.0 -2.3 0.4 -0.9 -0.5 -1.1 1.2 0.2 1.2
Fed-up feelings 0.3 0.5 3.3 -0.7 0.2 0.0 0.8 -0.2 0.1 -1.8 0.1 -0.5 -0.5 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.2 5.8 0.3 -0.5 0.0 1.9 -1.9 1.4 -1.4 1.0 -1.7 -1.6 -2.4
Relative age voice broke 1.0 1.5 5.8 0.8 1.5 0.0 -0.6 -1.0 -0.2 2.4 -0.6 -1.0 -0.9 -2.1
Taking other prescription medications 0.6 0.9 6.9 0.6 0.5 0.0 2.6 0.4 0.2 -0.4 0.3 -1.1 -0.0 -0.9
Age when periods started (menarche) 0.5 1.1 5.2 -0.8 0.1 0.0 -2.3 0.1 -1.8 0.4 -1.3 0.7 0.4 1.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.2 0.4 0.0 0.0 -0.0 -0.3 -0.1 0.3 -0.1 -0.1 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.5 0.5 1.1 0.0 1.2 0.7 -0.8 -1.1 -0.3 0.1 0.6 -0.6
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 7.2 -0.5 0.6 0.0 1.1 -2.7 -0.7 0.9 -0.6 -1.7 -1.6 -1.3
Qualifications: CSEs or equivalent 0.3 0.4 1.6 -1.1 -1.3 0.0 -0.7 0.1 0.2 -0.1 0.2 0.1 0.6 0.9
Serious illness, injury or assault to yourself 2.1 2.5 7.7 0.1 -0.5 0.0 2.0 -2.4 0.6 -1.4 0.7 -2.8 -2.2 -1.6
High blood pressure 0.5 1.3 5.9 1.1 -0.3 0.0 1.1 1.4 2.4 0.0 1.6 0.4 1.1 -0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.6 1.2 0.1 0.0 1.6 0.0 1.2 -0.4 0.9 -0.4 0.3 0.0
Multivitamins +/- minerals 2.2 2.8 10.2 1.4 -0.7 0.0 3.2 -0.8 1.3 -0.9 1.0 -2.9 -1.2 -2.1
Stomach or abdominal pain in last month 0.5 0.7 3.8 -2.0 1.0 0.0 -0.2 -0.2 -1.0 0.1 -1.0 0.4 -0.2 -0.3
Supplements: Glucosamine 0.9 1.1 4.4 -1.3 0.9 0.0 -1.0 -0.6 -2.1 -0.4 -1.6 -0.3 -1.0 -0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.0 1.0 -0.6 0.0 1.4 0.8 0.9 0.2 1.4 0.2 0.7 0.8
Medication: Atenolol 0.4 0.5 1.1 -0.4 -0.3 0.0 0.9 0.4 1.1 -1.0 0.4 -0.9 -0.4 -0.8
Medication: Levothyroxine sodium 0.4 0.6 1.9 -1.0 0.5 0.0 0.4 -0.8 -1.4 -1.3 -0.8 -0.1 -0.5 -0.2
Sitting height 0.7 5.3 31.0 -0.4 0.3 0.0 -3.1 -0.9 -2.9 5.6 -1.9 -0.8 -2.0 0.1
Chronic bronchitis/emphysema (father) 0.9 1.1 4.6 -1.5 1.1 0.0 1.8 0.5 0.0 -2.1 -0.1 0.5 0.5 -0.3
High blood pressure (mother) 0.6 0.9 3.1 1.1 0.2 0.0 0.7 -0.3 1.8 0.6 1.8 -0.9 -0.5 -0.8
Body mass index (BMI) 0.6 2.6 12.5 -0.8 0.4 0.0 3.5 -1.6 0.9 -2.1 0.7 -1.8 -1.4 -1.4
Impedance of leg (left) 0.4 1.9 6.2 2.5 -1.2 0.0 0.6 2.2 0.7 2.2 0.6 0.1 1.5 0.8
Leg predicted mass (left) 0.8 4.0 9.2 -2.7 1.5 0.0 -0.7 -3.0 -2.6 0.7 -2.1 -1.6 -2.9 -1.5
Trunk fat mass 0.6 2.6 8.2 -1.0 0.4 0.0 2.9 -2.0 -0.2 0.0 -0.1 -2.6 -2.0 -2.1
Waist circumference 0.3 1.2 7.9 0.1 1.1 0.0 2.8 -0.8 0.3 -0.5 0.3 -1.0 -0.7 -1.0
Number of incorrect matches in round 0.3 0.5 1.4 -0.8 1.2 0.0 -1.0 0.1 -0.7 -1.0 -0.5 0.6 0.3 0.2
Past tobacco smoking 0.1 0.2 0.9 0.2 -0.5 0.0 0.3 -0.9 0.1 -0.0 0.5 -0.7 -0.7 0.1
Alcohol usually taken with meals 1.9 3.0 7.7 -0.4 1.4 0.0 -1.7 -1.6 -2.3 1.5 -2.8 -1.5 -2.2 -1.8
Nervous feelings 0.2 0.4 1.4 -0.6 0.8 0.0 -0.0 0.6 0.8 0.2 0.4 1.2 1.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.1 -0.8 -0.5 0.0 -0.1 -1.5 0.9 -1.3 0.8 -1.6 -1.8 -1.7
Hearing difficulty/problems with background noise 0.6 0.9 3.1 -0.7 -0.6 0.0 0.5 -0.4 1.8 -1.3 1.8 0.3 0.3 -0.8
Hair/balding pattern: Pattern 2 0.5 0.6 1.7 -1.0 0.3 0.0 0.7 -1.0 0.2 -0.9 -0.3 -1.3 -0.7 -0.8
Had menopause 0.4 0.5 1.7 -1.3 0.8 0.0 0.3 -0.1 -0.7 -0.8 -0.9 -0.2 -0.3 -0.7
Had other major operations 0.4 0.5 2.3 -1.0 0.6 0.0 1.5 0.1 0.6 -0.5 0.7 -0.5 0.2 -1.1
Forced vital capacity (FVC) 1.1 4.3 14.0 -1.3 0.9 0.0 -3.0 -1.1 -3.7 2.2 -3.4 -0.6 -2.0 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 2.6 1.6 1.1 0.0 0.7 1.4 -0.2 -0.6 0.4 1.0 1.3 0.2
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 4.3 0.4 -1.0 0.0 0.2 1.2 2.1 -0.7 1.5 0.9 1.2 1.0
Qualifications: None of the above 0.9 1.9 6.1 0.6 -0.4 0.0 0.1 2.5 0.9 -0.8 0.6 1.9 2.3 1.9
Financial difficulties in last 2 years 0.1 0.2 0.5 -0.6 -0.5 0.0 0.5 0.6 0.2 0.7 0.1 0.2 0.1 0.5
Mouth/teeth dental problems 0.6 0.9 5.7 2.4 0.0 0.0 0.9 0.6 0.8 0.5 1.4 -0.3 0.3 0.1
Heart attack 1.5 1.9 4.6 -1.3 1.2 0.0 0.0 -1.9 -1.5 -1.0 -1.1 -1.4 -2.2 -1.6
Allergy 0.5 1.2 6.9 -0.8 -0.6 0.0 -2.6 -1.1 -1.3 0.9 -1.0 0.2 -0.8 0.6
Pain all over the body in last month 1.7 1.9 6.1 1.1 -0.8 0.0 2.5 -1.5 1.0 -1.1 1.8 -1.7 -1.1 -0.8
Diabetes (self-reported) 1.0 1.5 9.4 0.5 0.2 0.0 3.1 -0.0 1.5 -0.8 1.8 -0.7 0.4 0.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.4 1.0 0.5 0.0 1.6 0.3 0.7 1.1 0.9 -0.1 0.2 -0.5
Medication: Ramipril 0.1 0.2 0.9 -0.7 0.2 0.0 -0.4 -1.0 0.1 0.1 0.2 0.1 -0.2 -0.3
Medication: Simvastatin 1.0 1.5 5.2 2.3 -1.1 0.0 1.1 1.1 1.7 0.6 1.6 0.4 1.1 0.9
Fluid intelligence score 0.5 1.0 3.3 -1.4 1.8 0.0 -0.7 0.4 -1.0 -1.7 -0.6 0.7 -0.0 0.0
Illnesses of siblings 0.7 1.0 3.5 -0.6 -0.2 0.0 -0.5 -1.9 -1.3 -0.7 -0.8 -0.8 -1.4 -0.9
Neuroticism score 0.5 1.0 4.2 -1.2 0.2 0.0 1.1 -0.9 0.1 -0.4 -0.2 -1.3 -1.2 -2.0
Weight 0.4 2.2 5.3 -1.7 1.0 0.0 1.2 -2.3 -1.1 0.2 -0.8 -1.9 -2.3 -1.5
Impedance of arm (right) 0.1 0.6 1.9 0.6 -0.4 0.0 1.0 1.0 0.4 1.4 0.2 -0.9 0.5 -0.8
Arm fat percentage (right) 0.9 3.6 19.2 -0.5 0.0 0.0 4.4 -1.3 1.6 -2.0 1.4 -2.3 -1.0 -1.8
Trunk fat-free mass 0.6 3.7 9.9 -2.5 1.4 0.0 -2.7 -1.8 -3.1 1.4 -2.3 -0.3 -2.1 -0.0
Hip circumference 0.5 2.3 4.8 -1.2 1.4 0.0 2.2 -1.8 -1.1 0.6 -0.9 -2.1 -2.0 -1.8
Time employed in main current job 0.5 0.5 2.5 0.5 -0.8 0.0 0.3 -0.9 0.8 -1.6 0.7 -0.6 -0.3 -0.1
Alcohol intake versus 10 years previously 2.3 3.4 8.0 -0.3 0.3 0.0 1.4 2.6 1.8 -1.3 2.4 2.4 2.8 2.1
Father’s age at death 0.1 0.1 0.4 -0.1 0.1 0.0 -0.2 -0.1 -0.7 -0.6 -0.4 -0.0 -0.1 -0.3
Worrier / anxious feelings 0.1 0.2 0.8 -0.9 0.4 0.0 0.3 -0.3 0.6 -0.4 0.4 -0.1 -0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.5 10.3 1.4 -1.5 0.0 2.3 -2.1 2.4 -0.4 2.1 -3.2 -2.7 -2.7
Falls in the last year 1.1 1.5 3.9 -0.2 -0.8 0.0 2.0 -1.3 1.3 -0.7 1.0 -1.7 -1.1 -1.8
Hair/balding pattern: Pattern 3 0.2 0.4 1.7 0.1 -0.5 0.0 0.3 0.5 0.9 -0.8 1.3 0.1 -0.1 0.0
Number of live births 0.8 1.2 4.0 -1.3 0.7 0.0 0.6 -0.9 -0.8 0.2 -1.2 -1.4 -1.2 -2.0
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 9.3 -1.2 0.7 0.0 -1.9 -1.2 -3.1 1.9 -3.0 -0.9 -2.0 -0.7
Pulse rate 0.5 0.8 3.2 -1.4 -0.5 0.0 -1.8 -0.2 -1.2 0.5 -1.1 0.0 -0.3 -0.2
Happiness 0.4 0.4 1.5 -1.2 0.7 0.0 -0.6 -0.6 0.3 -1.1 -0.3 0.4 -0.3 -0.6
Noisy workplace 1.3 1.6 3.7 -1.9 0.3 0.0 0.2 -1.9 -1.4 -0.5 -1.6 -1.1 -1.5 -1.5
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.7 0.6 -0.9 0.0 1.7 -2.8 1.4 0.9 1.8 -2.0 -2.2 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.4 1.0 -0.7 0.0 0.7 -0.3 1.5 -0.6 1.0 -0.6 -0.2 0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 6.6 -0.6 -1.8 0.0 -2.6 0.1 0.7 -0.4 -0.1 1.3 0.5 0.6
Asthma 1.3 2.7 6.5 1.1 0.1 0.0 2.3 2.5 2.0 -0.1 2.0 1.1 2.5 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 -0.2 -0.1 0.0 0.9 -0.1 0.2 -0.7 -0.1 -0.8 -0.8 -0.6
Medication: Cholesterol lowering 0.4 0.6 2.2 0.9 -0.1 0.0 1.5 0.8 0.9 -0.2 1.0 0.4 1.0 0.5
Depression (self-reported) 0.7 0.8 2.5 1.6 -0.7 0.0 0.7 -0.2 1.2 -0.9 1.1 -0.9 -0.6 -0.9
Medication: Lansoprazole 0.4 0.5 3.1 -0.3 0.2 0.0 1.8 1.0 0.3 0.5 0.5 0.5 0.6 0.4
Prospective memory result 1.9 2.3 5.6 -1.1 -0.5 0.0 -0.4 -2.4 0.5 -1.9 -0.6 -2.1 -2.0 -2.2
Lung cancer (father) 0.2 0.2 0.6 -0.4 -0.6 0.0 0.4 -0.2 0.5 0.8 0.7 -0.4 -0.2 -0.0
Illnesses of mother 0.2 0.3 1.2 1.0 -0.5 0.0 0.6 0.3 -0.4 1.1 -0.3 -0.2 -0.2 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 10.4 -1.3 1.3 0.0 -1.5 -0.9 -3.1 1.2 -3.2 -0.2 -1.5 -0.5
Pulse wave Arterial Stiffness index 1.0 1.2 2.8 -1.3 0.4 0.0 -1.0 -1.4 -0.7 -0.3 -1.1 -1.1 -1.5 -1.7
Impedance of arm (left) 0.2 0.7 3.1 0.4 -0.3 0.0 1.2 0.2 0.1 1.8 -0.0 -1.2 0.1 -1.3
Arm fat mass (right) 0.6 2.5 10.0 -1.0 0.4 0.0 3.2 -1.7 0.7 -1.2 0.6 -2.3 -1.6 -1.7
Trunk predicted mass 0.7 3.7 10.3 -2.6 1.4 0.0 -2.7 -1.7 -3.2 1.4 -2.3 -0.2 -2.0 0.0
Standing height 0.9 8.9 26.3 -2.2 1.4 0.0 -4.8 -1.8 -4.6 5.1 -3.5 -0.5 -2.3 -0.3
Length of working week for main job 1.0 1.1 3.1 -1.3 -0.6 0.0 0.8 -1.4 -0.0 -0.8 -0.8 -1.8 -1.3 -1.1
Exposure to tobacco smoke at home 0.7 0.8 1.8 0.1 -1.1 0.0 -0.8 0.8 1.2 -0.1 1.1 1.0 1.0 1.4
Breastfed as a baby 0.2 0.2 0.6 0.4 0.7 0.0 -0.3 -0.4 0.0 0.3 0.1 0.8 0.6 0.4
Tense / ‘highly strung’ 0.2 0.4 2.2 -1.5 0.7 0.0 0.2 -0.7 0.1 -0.1 -0.0 0.1 -0.3 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.2 -1.1 -0.1 0.0 0.3 -1.5 -0.4 -1.8 -0.3 -1.7 -1.8 -2.0
Hair/balding pattern: Pattern 4 1.3 3.1 10.8 1.6 -2.1 0.0 3.3 1.3 2.4 -0.6 2.7 -0.3 0.7 1.1
Birth weight of first child 1.8 3.3 11.1 -3.3 1.7 0.0 -0.0 -1.5 -2.3 -0.9 -2.9 -0.8 -1.4 -1.7
Peak expiratory flow (PEF) 0.6 1.4 3.9 0.1 1.2 0.0 1.1 -1.0 -2.0 0.6 -1.8 -0.9 -1.3 -1.1
Pulse wave reflection index 0.9 1.2 2.9 -0.5 0.4 0.0 0.5 -1.3 0.7 -1.4 0.3 -1.7 -1.6 -1.6
Ever highly irritable/argumentative for 2 days 0.4 0.4 2.0 -1.4 -1.0 0.0 -0.6 -0.6 0.3 -0.4 0.6 -0.3 -0.5 0.1
Loud music exposure frequency 0.8 0.9 2.9 0.8 0.2 0.0 0.8 0.6 0.7 0.2 1.1 1.5 1.7 0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 2.7 1.4 0.3 0.0 0.2 -0.7 1.0 1.6 0.5 -0.2 -0.7 -1.1
Mouth/teeth dental problems: Bleeding gums 2.2 2.8 8.4 -2.9 1.6 0.0 0.1 -1.7 -2.2 -1.4 -1.9 -1.2 -1.8 -1.5
Blood clot in the leg (DVT) 1.7 2.2 6.7 -0.1 0.6 0.0 2.6 -1.1 -0.7 1.5 -0.5 -2.2 -1.9 -2.1
Medication: Paracetamol 0.2 0.4 3.1 -0.1 -0.0 0.0 1.8 0.6 -0.1 -0.4 -0.2 -0.4 -0.0 -0.1
Headache pain in last month 0.7 1.2 3.1 -1.8 0.7 0.0 0.4 -1.5 -0.8 -1.0 -0.6 -1.2 -1.6 -1.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 3.1 -1.4 0.4 0.0 -1.7 -1.5 -1.8 0.0 -1.6 -0.5 -1.4 -0.2
Glaucoma (self-reported) 0.4 0.5 1.6 0.7 0.8 0.0 -0.5 1.2 -0.1 -0.0 0.3 1.3 0.7 0.7
Gout (self-reported) 0.3 0.3 1.0 0.2 -0.6 0.0 0.2 -0.2 0.4 0.1 0.9 0.8 0.9 1.0
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 5.6 -0.3 0.5 0.0 2.4 -1.4 -0.6 -1.2 -0.3 -1.1 -1.3 -1.1
Medication: Amlodipine 0.7 0.9 5.1 -1.2 -0.7 0.0 -0.3 -0.8 0.9 -2.3 0.8 -0.8 -0.5 -0.2
Medication: Ventolin 100micrograms inhaler 1.4 1.8 5.0 1.5 -0.4 0.0 1.7 1.6 2.2 0.2 2.1 0.4 1.6 -0.1
Birth weight 0.6 1.3 3.1 -1.2 1.2 0.0 0.1 -1.4 -1.8 1.1 -1.3 -0.8 -1.2 -0.8
Chronic bronchitis/emphysema (mother) 1.4 1.6 3.6 -1.4 1.2 0.0 0.9 -1.5 -0.1 -1.9 -0.6 -1.3 -1.5 -1.9
High blood pressure (siblings) 1.2 1.7 5.5 1.6 -0.9 0.0 2.1 0.1 2.3 0.5 1.6 -1.3 -0.3 -0.9
Forced vital capacity (FVC), Best measure 1.2 4.5 15.2 -1.1 1.3 0.0 -3.2 -0.8 -3.9 2.1 -3.6 0.0 -1.6 0.1
Body fat percentage 0.9 3.5 21.1 -0.3 0.0 0.0 4.6 -1.4 1.0 -0.8 0.7 -2.7 -1.4 -2.1
Leg fat percentage (right) 0.7 2.5 17.0 0.2 -0.5 0.0 4.1 -0.7 1.4 -1.2 1.0 -1.9 -0.7 -1.1
Arm fat-free mass (right) 0.6 3.2 7.5 -2.0 0.9 0.0 -1.4 -2.5 -2.7 1.5 -2.1 -1.2 -2.6 -0.6
Exposure to tobacco smoke outside home 0.2 0.3 1.1 -0.7 -0.3 0.0 -1.1 0.0 0.4 -0.0 0.5 0.2 -0.5 0.7
Comparative body size at age 10 0.2 0.4 1.6 -0.6 0.4 0.0 1.3 -0.6 -0.9 -0.4 -0.9 -0.1 -0.6 0.3
Number of full brothers 0.3 0.3 1.0 0.3 -0.9 0.0 -0.1 0.3 1.0 -0.6 0.9 -0.8 0.3 0.2
Worry too long after embarrassment 0.6 1.0 3.7 -1.6 0.5 0.0 1.2 -0.8 -0.6 0.2 -0.4 -0.8 -0.9 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 5.6 -2.4 0.3 0.0 -0.5 -1.8 -0.8 -1.4 -0.1 -1.3 -1.6 -1.0
Wheeze or whistling in the chest in last year 0.4 0.7 3.5 -0.3 -0.1 0.0 1.9 0.4 1.2 -0.5 1.3 -0.3 0.4 -0.1
Number of children fathered 0.5 0.6 2.3 0.5 0.2 0.0 1.5 0.8 1.0 -0.4 0.9 -0.9 -0.2 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.1 0.2 0.0 0.6 -0.6 0.1 0.3 0.4 -0.5 -0.2 0.4
Age at first live birth 0.4 0.6 3.2 1.8 -0.1 0.0 -1.4 -0.1 -0.4 0.6 0.4 0.6 0.6 0.6
Pulse wave peak to peak time 0.9 1.0 3.1 1.2 -0.5 0.0 0.5 1.3 0.4 0.7 1.0 1.1 1.4 1.8
Health satisfaction 0.6 0.8 1.6 -1.0 -1.0 0.0 0.6 -1.0 1.3 -0.8 0.8 -0.8 -0.8 -0.9
Shortness of breath walking on level ground 0.6 0.8 2.9 0.7 0.0 0.0 1.7 0.1 1.3 0.3 1.3 -0.8 0.2 -0.9
Qualifications: College or University degree 1.0 3.0 9.5 -0.2 0.0 0.0 0.6 -3.1 -0.1 2.1 -0.2 -2.6 -2.6 -2.3
Eye problems/disorders: None of the above 1.4 1.6 6.1 0.8 -2.5 0.0 -0.8 -0.1 1.9 0.4 1.9 0.2 0.5 1.6
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.0 -0.7 0.2 0.0 -1.3 -1.2 -1.2 -0.3 -1.4 0.2 -1.0 -0.3
Emphysema/chronic bronchitis 0.6 0.7 4.0 -0.0 0.3 0.0 1.1 2.0 0.3 -0.4 0.5 0.3 1.3 0.2
Medication for pain relief, constipation, heartburn 0.7 1.2 4.2 -0.2 1.3 0.0 -2.1 0.7 -1.0 0.9 -1.2 1.3 1.2 0.4
Neck or shoulder pain in last month 1.0 1.4 7.4 -1.6 1.6 0.0 0.4 -0.1 -0.4 -2.7 -0.3 -0.1 -0.5 -1.6
Medication: Blood pressure 0.3 0.5 1.4 0.6 0.3 0.0 0.8 1.2 1.1 -0.2 1.0 -0.2 0.3 -0.8
Angina (self-reported) 0.3 0.4 0.9 -0.4 -1.0 0.0 0.8 0.0 0.9 0.3 0.9 -0.9 -0.8 -0.1
Migraine (self-reported) 1.3 1.7 4.1 -1.0 1.4 0.0 0.8 -2.0 -1.5 0.3 -1.0 -1.5 -1.5 -1.7
Medication: Ibuprofen 0.3 0.3 0.9 -0.4 0.1 0.0 0.7 0.2 -0.3 -0.8 -0.4 -0.8 -0.9 -0.7
Medication: Allopurinol 0.7 1.0 2.6 -0.3 -0.8 0.0 0.4 0.8 0.7 0.8 1.4 1.2 1.4 1.6
Medication: Omeprazole 0.6 0.8 2.2 -0.3 -0.5 0.0 -0.1 -1.5 0.5 1.2 0.4 -1.3 -1.3 -0.5
Medication: Seretide 50 evohaler 2.1 2.5 5.9 1.3 -1.2 0.0 1.4 1.8 2.4 -0.3 2.4 1.0 1.8 1.6
Mean time to correctly identify matches 1.5 2.8 8.4 0.5 -0.1 0.0 1.4 -2.8 0.3 1.2 -0.0 -2.9 -2.7 -1.9
Heart disease (mother) 0.4 0.5 1.8 -1.3 0.1 0.0 -1.0 0.3 -0.2 -1.4 0.6 -0.2 0.1 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.3 0.3 0.5 0.0 1.1 0.8 0.4 -1.0 0.2 0.4 0.5 0.0
Whole body fat mass 0.7 2.7 10.8 -1.0 0.5 0.0 3.3 -2.0 0.1 -0.5 0.1 -2.5 -1.8 -2.0
Leg fat mass (right) 0.5 2.0 10.0 -0.6 0.3 0.0 3.2 -1.6 0.2 -0.6 -0.0 -2.0 -1.5 -1.5
Arm predicted mass (right) 0.8 4.0 9.5 -2.2 1.2 0.0 -1.4 -2.7 -3.1 1.4 -2.5 -1.4 -3.0 -0.9
Pulse rate, automated reading 0.4 1.3 5.3 -2.3 0.2 0.0 -1.9 0.3 -1.2 -0.3 -1.5 1.2 0.5 0.3
Alcohol intake frequency. 0.4 1.0 3.5 -1.0 -0.2 0.0 1.0 -0.4 1.3 -1.6 1.9 0.5 0.6 0.7
Comparative height size at age 10 0.3 1.9 6.4 -0.1 -1.4 0.0 -1.2 -2.0 -1.0 2.5 0.0 -1.3 -1.9 0.2
Number of full sisters 0.6 0.7 3.7 -0.3 1.9 0.0 0.8 0.6 -0.1 -1.4 -0.1 0.7 0.9 -0.3
Suffer from ‘nerves’ 0.6 0.9 3.9 0.9 -0.5 0.0 1.1 0.4 2.0 0.7 1.4 0.4 0.9 0.1
Overall health rating 1.1 2.3 7.0 -0.0 -1.7 0.0 1.8 -0.3 2.6 -2.5 2.2 -0.8 0.1 -0.4
Chest pain or discomfort 1.0 1.5 3.5 -0.6 -1.4 0.0 1.7 -0.8 1.9 -1.1 1.6 -1.1 -0.9 -1.1
Had major operations 0.5 0.6 1.3 0.7 -0.4 0.0 1.2 -0.2 -1.1 1.0 -0.1 -1.1 -1.1 -0.1
Age at last live birth 0.6 0.9 3.6 -0.2 1.1 0.0 -1.9 0.5 -1.1 0.3 -0.5 1.2 1.0 0.8
Family relationship satisfaction 0.6 0.7 3.1 -0.9 -0.4 0.0 0.9 0.1 1.2 -1.8 1.1 -0.3 0.2 -0.3
Leg pain on walking 2.4 3.0 6.5 -2.5 0.1 0.0 0.5 -2.0 -1.0 -2.3 -1.9 -1.5 -1.8 -2.5
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.0 -0.4 -0.1 0.0 0.7 -1.0 0.2 -0.4 0.3 -0.8 -0.6 -0.1
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.7 -0.4 -0.1 0.0 0.1 1.5 -0.5 -0.4 -0.4 1.7 1.6 1.9
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 3.6 0.9 0.9 0.0 -1.5 1.9 -1.7 1.6 -1.0 1.8 1.9 1.1
Medication: Aspirin 0.1 0.2 1.1 0.6 -0.3 0.0 1.1 0.2 -0.0 0.4 0.5 -0.1 0.0 0.3
Supplements: Vitamin C 1.1 1.3 4.8 -0.7 -0.5 0.0 1.0 -1.1 -0.3 -0.9 0.0 -2.2 -1.7 -1.8
Knee pain experienced in last month 0.8 1.2 6.9 -0.5 -1.0 0.0 1.2 -0.3 1.4 -2.6 1.2 -0.3 -0.2 -0.5
Hypertension (Self-reported) 0.5 1.3 5.9 0.9 -0.6 0.0 1.1 1.4 2.4 0.2 1.7 0.4 1.1 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 6.1 -2.5 0.7 0.0 0.8 -0.7 -0.5 -0.6 -0.9 -0.6 -0.9 -0.7
Illnesses of father: Heart disease 0.8 1.2 3.4 0.5 -1.8 0.0 0.0 -1.8 1.3 1.2 0.5 -1.3 -0.9 0.1
Illnesses of siblings: Diabetes 0.2 0.3 1.5 -1.2 0.4 0.0 0.2 0.1 0.3 0.4 0.5 0.4 0.7 0.5
Smoking status: Previous 0.6 0.9 1.9 -1.3 1.4 0.0 -1.3 0.9 -0.4 0.0 -0.5 1.4 1.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 7.0 -2.2 0.5 0.0 -2.6 -1.1 -2.2 1.5 -1.9 0.2 -1.3 -0.0
Whole body fat-free mass 0.7 4.0 9.4 -2.7 1.4 0.0 -2.0 -2.5 -3.1 1.1 -2.3 -1.0 -2.6 -0.7
Leg fat-free mass (right) 0.8 4.5 10.8 -2.9 1.5 0.0 -1.2 -3.3 -2.6 0.5 -2.1 -1.6 -3.1 -1.6
Arm fat percentage (left) 1.0 4.0 20.5 -0.7 0.1 0.0 4.5 -1.7 1.3 -1.8 1.0 -2.6 -1.4 -2.2
Average weekly red wine intake 0.6 0.9 2.1 -0.7 0.3 0.0 0.3 -1.0 -1.3 1.0 -1.4 -1.1 -1.4 -0.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 0.1 -0.0 0.0 1.2 0.1 0.7 0.7 0.1 0.8 1.2 1.0
Mood swings 0.2 0.3 0.9 -0.7 -0.6 0.0 -0.6 0.3 -0.0 -0.7 0.3 -0.3 -0.3 -0.9
Loneliness, isolation 0.3 0.5 1.3 -1.1 -0.4 0.0 0.1 -0.9 -0.0 -0.0 -0.6 -1.0 -1.1 -0.6
Long-standing illness, disability or infirmity 2.2 3.4 13.0 1.7 -1.9 0.0 3.6 -0.6 2.6 -0.3 2.5 -1.9 -0.5 -0.9
Ever had bowel cancer screening 0.2 0.3 0.9 0.3 0.2 0.0 0.9 0.2 -0.5 1.0 -0.4 -0.7 0.0 -0.5
Diabetes diagnosed by doctor 1.1 1.8 10.6 -0.0 0.4 0.0 3.3 0.0 1.7 -1.3 2.1 -0.5 0.5 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 -0.3 0.7 0.0 1.1 0.7 -0.1 -0.3 -0.6 -0.1 0.2 -0.7
Friendships satisfaction 0.6 0.8 2.3 -1.3 -0.3 0.0 0.2 -1.5 0.4 -1.0 -0.3 -1.1 -1.2 -0.8
Qualifications: nursing, teaching 1.6 2.5 11.8 0.0 0.2 0.0 0.0 -3.4 -1.0 1.3 -0.6 -2.0 -2.5 -1.5
Commuting to job workplace: Walk 1.8 2.0 5.6 -0.2 0.1 0.0 -0.9 -2.4 -1.0 -0.3 -0.7 -2.3 -2.2 -1.8
Eye problems/disorders: Cataract 1.7 2.0 4.2 -1.7 1.7 0.0 -0.5 -1.1 -2.0 -0.1 -2.1 -1.2 -1.3 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.5 0.9 2.2 -0.9 1.5 0.0 1.5 1.0 -1.3 0.1 -1.3 0.2 0.4 -0.2
Medication for cholesterol 0.3 0.5 1.5 -0.3 -0.2 0.0 -1.2 -0.8 -1.2 0.0 -0.9 0.3 -0.2 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 2.3 -0.5 -0.4 0.0 -0.1 -1.5 0.3 0.0 1.4 -1.3 -1.0 -1.1
Back pain experienced in last month 1.6 2.3 6.0 -2.1 0.2 0.0 -0.0 -1.1 -1.1 -2.4 -1.0 -1.9 -1.8 -2.0
Mineral and other dietary supplements 3.6 4.8 13.5 1.1 -0.1 0.0 -0.3 3.1 1.4 -1.1 1.2 3.7 3.6 3.2
Breast cancer (self-reported) 0.8 0.9 3.5 -0.9 -0.7 0.0 1.9 -0.9 -0.1 -1.2 -0.3 -1.4 -0.6 -0.6
Asthma (self-reported) 1.0 1.9 4.5 0.8 0.1 0.0 2.0 2.1 1.7 -0.4 1.7 0.8 2.1 0.8
Osteoporosis (self-reported) 1.2 1.4 3.8 0.1 -1.7 0.0 -0.0 -1.7 1.2 0.1 0.8 -1.9 -1.6 -1.3
Osteoarthritis (self-reported) 0.8 1.0 2.3 -0.9 0.1 0.0 -0.2 -1.5 -0.6 -1.3 -0.8 -1.4 -1.3 -1.3
Medication: Aspirin 0.2 0.2 1.8 0.4 -0.2 0.0 1.4 0.3 -0.2 0.1 0.3 -0.1 -0.0 0.2
Medication: Gliclazide 1.0 1.1 2.8 1.0 0.6 0.0 1.2 1.1 1.0 -0.3 1.4 1.3 1.7 1.0
Illnesses of father: None of the above (group 1) 1.1 1.4 4.2 -1.1 2.0 0.0 -2.0 0.4 -1.3 -1.3 -0.8 1.3 0.4 -0.1
Smoking status: Current 1.2 1.9 8.8 1.4 -3.0 0.0 0.6 -1.0 1.4 0.5 1.0 -1.6 -1.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.6 -0.5 1.9 0.0 0.7 -0.5 -0.9 -0.1 -1.5 -0.3 -0.2 -1.1
Whole body water mass 0.7 3.8 8.9 -2.6 1.4 0.0 -1.9 -2.4 -3.0 1.1 -2.3 -0.8 -2.5 -0.6
Leg predicted mass (right) 0.8 4.2 10.2 -2.9 1.4 0.0 -1.2 -3.2 -2.6 0.5 -2.0 -1.6 -3.0 -1.5
Arm fat mass (left) 0.6 2.6 10.7 -1.0 0.3 0.0 3.3 -1.8 0.4 -1.1 0.5 -2.4 -1.8 -1.7
Number of self-reported non-cancer illnesses 0.7 1.2 7.5 -0.1 0.4 0.0 2.7 -0.4 1.0 -0.5 0.7 -1.2 -0.3 -1.6
Average weekly champagne plus white wine intake 0.5 0.8 3.2 0.7 1.1 0.0 -0.9 -0.3 -1.8 1.0 -1.0 -0.3 -0.6 -0.2
Miserableness 0.5 0.9 5.2 -1.4 -0.3 0.0 -0.0 -0.1 -0.1 0.3 -0.5 -1.4 -0.9 -2.3
Guilty feelings 1.8 2.8 11.3 -1.9 0.8 0.0 3.4 -1.2 -0.5 -1.5 -0.5 -1.6 -1.6 -2.4
Wears glasses or contact lenses 0.5 0.5 1.5 0.4 1.1 0.0 -0.5 0.2 -1.2 0.9 -1.2 0.6 0.3 -0.4
Ever taken oral contraceptive pill 0.6 0.7 2.3 1.5 -0.9 0.0 0.4 -0.5 1.0 -0.3 1.2 -0.9 -0.5 -0.7
Hearing aid user 0.2 0.3 1.1 0.2 -0.5 0.0 0.4 0.5 0.1 -1.1 0.7 -0.6 0.3 0.2
Mother’s age at death 0.3 0.3 3.0 0.1 -0.2 0.0 0.2 -0.4 0.2 1.7 -0.5 -0.1 -0.1 -0.5
Financial situation satisfaction 0.3 0.4 2.2 -1.2 -1.5 0.0 0.1 -0.0 0.1 0.2 0.1 -0.0 -0.2 0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 2.2 -0.6 -1.5 0.0 -0.4 0.1 0.8 0.2 0.7 -0.2 0.1 0.5
Commuting to job workplace: Public transport 0.5 0.5 1.6 -0.7 0.2 0.0 -0.2 -1.2 0.5 -1.3 0.3 -0.6 -0.8 -1.0
Eye problems/disorders: Glaucoma 0.5 0.6 2.6 -0.2 0.3 0.0 -0.7 1.0 0.1 -0.0 0.2 1.6 0.9 1.2
Medication: Blood pressure 0.3 0.5 2.1 0.4 -1.0 0.0 1.0 0.3 1.4 0.5 0.6 -0.5 -0.0 -0.5
Pain type(s) experienced in last month: Hip pain 1.9 2.4 6.6 -1.6 -0.2 0.0 0.6 -2.1 -0.2 -1.0 -0.3 -2.3 -2.6 -2.4
Supplements: Fish oil (including cod liver oil) 3.9 5.0 13.6 -1.0 0.8 0.0 0.7 -3.7 -1.3 1.4 -1.0 -3.6 -3.6 -3.0
High cholesterol (Self-reported) 0.4 0.8 2.6 0.7 -1.4 0.0 0.8 0.1 1.6 -0.1 1.2 -0.8 -0.1 -0.8
Medication: Bendroflumethiazide 0.6 0.9 2.6 0.8 -1.6 0.0 1.2 -0.4 1.6 0.3 1.3 -0.9 -0.4 -0.2
Medication: Paracetamol 0.3 0.4 1.7 -0.9 0.3 0.0 1.3 0.5 -0.8 -0.4 -0.7 -0.4 -0.4 -0.3
Medication: Lisinopril 0.8 1.1 2.5 1.2 -0.1 0.0 1.0 1.6 1.5 0.2 1.6 0.9 1.1 0.0
Medication: Atorvastatin 0.7 0.9 2.8 -0.2 -0.5 0.0 1.2 -0.9 0.7 -0.6 0.6 -1.7 -1.3 -1.2
Illnesses of father: High blood pressure 2.1 2.6 7.4 1.9 -1.6 0.0 2.7 -0.5 2.6 0.7 1.9 -1.8 -0.6 -0.7
Alcohol drinker status: Never 0.3 0.3 1.2 -1.1 0.3 0.0 0.0 -0.6 0.6 -0.6 0.8 0.6 0.3 0.2
Ever smoked 0.1 0.1 0.4 0.1 0.3 0.0 0.4 0.6 0.1 -0.1 -0.6 0.2 0.3 -0.6
Basal metabolic rate 0.6 3.3 7.0 -2.5 1.3 0.0 -1.2 -2.5 -2.6 0.9 -1.9 -1.3 -2.6 -0.9
Leg fat percentage (left) 0.8 2.8 17.4 0.1 -0.5 0.0 4.2 -0.9 1.5 -1.6 1.1 -2.1 -0.8 -1.2
Arm fat-free mass (left) 0.4 2.2 5.0 -1.9 0.8 0.0 -1.3 -1.9 -2.2 1.0 -1.6 -1.0 -2.2 -0.2
Number of operations (self-reported) 1.2 1.8 6.5 0.4 0.1 0.0 2.5 -0.2 -0.7 1.4 -0.7 -2.0 -1.4 -2.0
Average weekly beer plus cider intake 3.8 5.5 20.3 0.8 0.5 0.0 -0.4 2.8 0.1 0.1 0.7 4.5 4.3 3.4
Irritability 0.2 0.3 1.2 0.5 0.0 0.0 -0.8 -0.4 -0.8 0.5 -0.5 -0.3 -0.2 -1.1
Risk taking 0.5 0.7 1.6 0.4 -0.3 0.0 0.8 1.1 0.7 0.4 1.0 1.3 1.1 1.0
Ever had prostate specific antigen (PSA) test 1.3 1.5 7.5 -0.5 1.3 0.0 2.7 -0.8 -0.6 0.1 -0.2 -1.1 -1.1 -1.9
Fractured/broken bones in last 5 years 0.7 0.9 2.0 -0.4 1.4 0.0 1.3 -0.1 -1.3 1.0 -1.4 -0.5 -0.5 -0.8
Age started oral contraceptive pill 0.7 0.9 3.4 -0.4 1.1 0.0 -0.5 -1.0 -1.6 0.9 -1.8 -0.2 -0.5 -0.0
Diastolic blood pressure, automated reading 0.4 1.4 3.0 0.1 -1.6 0.0 -1.6 0.6 1.7 -0.2 1.3 1.4 1.2 1.4
Ever depressed for a whole week 0.9 1.1 5.0 -1.3 -0.5 0.0 0.3 -0.4 1.7 -2.2 1.4 0.2 0.3 0.2
Unable to work because of sickness or disability 0.7 0.9 6.5 -1.1 -0.8 0.0 0.8 0.0 0.4 -2.5 0.5 0.1 0.3 0.3
Commuting to job workplace: Cycle 0.7 0.9 3.4 1.5 -0.3 0.0 0.9 -0.3 1.8 0.0 1.7 0.2 0.8 -0.1
Myopia 0.9 1.3 4.7 2.2 -0.7 0.0 0.5 -1.4 0.2 -0.4 0.2 -2.0 -1.3 -1.3
Vascular/heart problems diagnosed by doctor 0.4 1.1 5.3 -0.3 0.3 0.0 -1.2 -1.2 -2.3 0.5 -1.7 -0.1 -0.8 0.6
Cholesterol lowering medication 0.8 1.1 4.6 1.4 -1.0 0.0 0.5 0.8 2.1 0.0 1.8 -0.5 0.2 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 5.2 -0.1 -1.2 0.0 -0.3 -2.3 0.7 0.9 0.6 -1.8 -1.9 -0.7
Pain experienced in last month 1.6 2.6 9.4 2.4 -0.3 0.0 -1.2 1.3 0.6 3.1 1.0 1.5 1.6 2.0
Supplements: Calcium 1.4 1.5 3.8 -1.4 0.3 0.0 -0.7 -1.9 -1.0 0.5 -1.1 -1.5 -1.7 -1.6
Basal cell carcinoma (self-reported) 0.6 0.8 2.4 -1.6 1.5 0.0 0.5 1.1 -0.8 0.2 -1.0 0.5 0.3 -0.5
Heart attack/myocardial infarction (self-reported) 1.3 1.7 4.6 -1.0 1.1 0.0 0.0 -1.9 -1.3 -0.8 -0.9 -1.4 -2.1 -1.5
Deep venous thrombosis (DVT) (self-reported) 1.5 2.0 7.8 -0.2 0.7 0.0 2.8 -0.7 -0.6 1.3 -0.5 -2.0 -1.7 -2.0
Heart disease (siblings) 0.6 0.7 2.5 -0.5 0.6 0.0 -1.6 1.0 -0.8 0.3 -0.7 1.1 0.7 0.8
Alcohol drinker status: Previous 0.2 0.2 1.2 -0.0 -1.1 0.0 -0.4 -0.5 0.4 -0.0 0.5 0.1 0.4 0.6
Pack years of smoking 0.7 1.0 3.0 -1.7 1.1 0.0 0.5 -0.3 -1.0 -0.7 -1.5 -0.1 -0.7 -1.4
Impedance of whole body 0.2 1.0 5.3 1.3 -0.9 0.0 0.9 1.0 0.3 2.3 0.1 -0.8 0.6 -0.4
Leg fat mass (left) 0.5 2.0 9.9 -0.7 0.4 0.0 3.1 -1.6 0.2 -0.8 -0.0 -2.0 -1.5 -1.4
Arm predicted mass (left) 0.5 2.3 5.4 -1.8 0.7 0.0 -1.5 -2.1 -2.2 1.2 -1.6 -1.1 -2.3 -0.2