Hub : Genes

LZIC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.4840 0.0910 4.4e-06 0.243 NA 0.047 NA 0.242 1.7e-08 NA 0.0120 NA 1.8e-08
2 METSIM Adipose 0.0414 0.0212 4.1e-03 0.009 0.015 0.011 0.016 0.013 1.4e-02 0.0021 0.0084 0.0015 4.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.6 1.8 1.2 -1.3
Bipolar Disorder or Schizophrenia 1.0 2.4 4.7 0.1 -2.2
Depressed Affect (Nagel 2018) 0.3 0.6 0.8 0.6 0.9
Depression (Nagel 2018) 0.4 0.6 0.8 -0.9 0.7
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.1 -0.6 -1.0
Neuroticism (Nagel 2018) 1.4 3.2 5.4 1.0 2.3
Schizophrenia (2018) 0.8 1.7 2.7 -0.8 -1.6
Schizophrenia vs Biploar Disorder 1.1 1.4 2.8 -1.7 -0.2
Worry (Nagel 2018) 1.7 3.6 7.1 -0.1 2.7
Alzheimer’s Disease (in mother) 0.8 0.9 1.2 1.1 0.8
Alzheimer’s Disease (in father) 0.4 0.4 0.4 -0.6 0.6
Alzheimer’s Disease (including proxy) 0.4 0.6 0.9 0.9 0.5
Crohns Disease (2017) 0.0 0.1 0.1 0.3 -0.2
Irritable Bowel Disease (IBD) 0.5 1.3 2.5 -0.1 1.6
Ulcerative Colitis (UC) 1.3 2.5 4.9 0.2 2.2
Major Depression (MDD) 1.1 1.3 2.6 -0.3 -1.6
Reaction Time 0.3 0.5 0.8 0.9 0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.6 0.7 0.7 -0.8
Breast Cancer 0.7 1.7 2.9 0.7 -1.7
Ovarian Cancer 0.4 0.5 0.9 -0.0 -1.0
Prostate Cancer 0.5 0.7 1.1 -1.1 0.4
Age at First Birth 0.3 0.4 0.8 0.1 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 0.9 -0.0
Coronary Artery Disease (CAD) 0.3 0.3 0.3 0.6 -0.6
Crohns Disease (2012) 0.3 0.4 0.5 0.6 0.7
Mean Putamen Volume 0.5 0.6 1.0 -0.5 -1.0
Fasting Glucose 0.2 0.2 0.4 0.6 -0.1
HbA1C 0.4 0.4 0.8 0.1 -0.9
HDL Cholesterol 0.1 0.2 0.4 0.0 -0.7
LDL Cholesterol 0.1 0.2 0.3 -0.2 0.6
Lupus 0.0 0.0 0.0 -0.1 0.1
Neuroticism (2016) 0.1 0.1 0.1 -0.3 0.3
Primary Biliary Cirrhosis 0.6 0.8 1.4 1.2 0.5
Rheumatoid Arthritis 1.0 1.4 2.5 0.5 1.6
Schizophrenia (2014) 0.1 0.3 0.5 0.0 -0.7
Triglycerides 0.2 0.3 0.3 -0.5 0.6
Type 2 Diabetes (T2D) (2012) 5.5 6.3 12.6 -0.0 -3.5
Ulcerative Colitis 1.6 2.3 4.3 0.6 2.1
Blood Eosinophil Count 2.9 22.6 44.8 0.7 6.7
Blood Platelet Count 0.6 6.8 13.5 0.3 3.7
Blood Red Count 0.0 0.3 0.4 0.4 -0.7
Blood White Count 1.6 12.0 17.9 -4.2 2.5
Heel T-Score 0.0 0.2 0.5 0.7 -0.0
BMI 0.3 1.7 3.1 -1.8 -0.6
Height 0.4 8.4 13.0 3.6 -1.9
Waist Hip Ratio (WHR) 0.1 0.6 0.9 -1.0 -0.4
Systolic Blood Pressure 0.1 0.4 0.5 -0.7 -0.5
Smoking Status 0.0 0.1 0.2 -0.4 -0.2
Allergy or Eczema 0.0 0.1 0.2 0.4 0.1
Cardiovascular Disease 1.9 6.3 8.8 -2.0 3.0
Hypothyroidism (self reported) 0.6 1.3 2.2 0.6 1.5
Respiratory disease 1.9 4.3 7.4 -1.0 2.7
Type 2 Diabetes (T2D) (2018) 1.3 2.4 4.6 -2.1 -0.4
Lung FEV1/FVC ratio 0.6 2.8 3.4 -1.8 -1.5
Lung FVC 0.9 4.8 9.6 3.1 -0.2
Neuroticism 1.6 3.8 7.7 0.1 2.8
Chronotype (morning person) 0.3 0.7 1.4 -1.2 0.0
Hair Pigment 0.2 4.5 7.7 2.8 -1.1
Tanning 0.2 1.9 2.8 -1.0 -1.7
Hand grip strength (left) 0.9 2.2 4.5 2.1 -0.0
Number of treatments/medications taken 0.7 1.2 2.5 -0.1 1.6
Average weekly spirits intake 1.9 2.4 2.7 -1.5 1.6
Sensitivity / hurt feelings 1.1 2.0 2.2 1.3 1.5
Frequency of depressed mood in last 2 weeks 1.7 2.4 4.1 -2.0 0.9
Hearing difficulty/problems: Yes 0.2 0.3 0.5 -0.7 0.0
Relative age of first facial hair 1.1 2.2 3.3 1.8 1.1
Other serious medical condition/disability diagnosed by doctor 4.5 5.8 9.5 -3.1 1.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.6 0.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 0.2 -0.6
Systolic blood pressure, automated reading 0.5 1.6 3.1 -0.1 -1.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 0.6 -0.2
Angina 0.5 0.6 0.9 -0.6 1.0
Medication for hormone replacement therapy 0.0 0.0 0.0 -0.1 0.2
Vitamin and mineral supplements 1.0 1.3 2.4 0.5 -1.6
Supplements: Zinc 1.4 1.5 2.7 -1.6 -0.6
Medication: Co-codamol 0.2 0.3 0.3 0.5 -0.5
Medication: Metformin 0.8 1.1 2.2 -1.5 0.1
Diabetes (father) 0.1 0.2 0.2 0.4 -0.5
Diabetes (mother) 0.7 0.9 1.0 -1.0 -0.9
Severe depression (siblings) 0.4 0.5 0.9 1.0 -0.1
Pack years adult smoking proportion 1.4 2.2 4.2 2.0 -0.5
Impedance of leg (right) 0.1 0.5 0.9 0.1 1.0
Leg fat-free mass (left) 0.6 2.9 3.2 1.8 -1.6
Trunk fat percentage 0.0 0.2 0.4 0.2 -0.6
Hand grip strength (right) 1.2 3.3 5.7 2.4 -0.9
Townsend deprivation index at recruitment 0.5 0.8 1.5 1.2 0.0
Current tobacco smoking 0.6 1.0 1.1 -1.1 -0.9
Average weekly fortified wine intake 6.2 7.2 14.4 0.2 -3.8
Maternal smoking around birth 1.7 2.5 2.7 1.6 -1.5
Fed-up feelings 0.1 0.2 0.2 -0.4 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.7 -1.3 -0.3
Relative age voice broke 0.7 1.1 2.1 -0.0 1.5
Taking other prescription medications 0.2 0.2 0.4 0.3 0.6
Age when periods started (menarche) 0.3 0.6 1.2 1.1 -0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 -0.1 -0.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 0.8 0.8 0.9
Qualifications: CSEs or equivalent 0.3 0.4 0.4 -0.5 0.7
Serious illness, injury or assault to yourself 0.4 0.4 0.7 -0.4 0.9
High blood pressure 0.4 1.0 1.1 -1.0 1.0
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 -0.1 0.7
Multivitamins +/- minerals 0.9 1.1 1.3 -1.0 1.2
Stomach or abdominal pain in last month 0.6 0.7 1.4 1.2 0.1
Supplements: Glucosamine 0.8 1.1 1.6 1.3 -0.8
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 2.6 -1.6 1.1
Medication: Atenolol 0.1 0.2 0.3 -0.2 -0.5
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.8 0.4
Sitting height 0.2 1.2 2.3 1.5 -0.2
Chronic bronchitis/emphysema (father) 1.9 2.2 4.2 0.5 2.0
High blood pressure (mother) 1.9 2.7 2.9 -1.6 1.7
Body mass index (BMI) 0.1 0.5 0.7 -0.4 -0.9
Impedance of leg (left) 0.1 0.5 1.0 -0.1 1.0
Leg predicted mass (left) 0.5 2.9 2.9 1.7 -1.7
Trunk fat mass 0.2 0.7 1.2 0.5 -1.1
Waist circumference 0.4 1.4 2.7 0.1 -1.6
Number of incorrect matches in round 0.1 0.2 0.3 0.6 -0.1
Past tobacco smoking 0.2 0.4 0.7 -0.2 -0.8
Alcohol usually taken with meals 1.6 2.6 5.0 2.2 0.3
Nervous feelings 0.6 1.1 2.1 -0.2 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 1.7 -0.9 1.3
Hearing difficulty/problems with background noise 0.8 1.3 2.5 -1.6 0.4
Hair/balding pattern: Pattern 2 1.2 1.5 2.2 0.9 1.5
Had menopause 0.6 0.8 0.9 0.8 -1.0
Had other major operations 0.3 0.3 0.7 -0.8 -0.1
Forced vital capacity (FVC) 2.2 8.4 16.4 4.0 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.9 -0.3 -0.9
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.7 -1.3 -0.2
Qualifications: None of the above 0.3 0.6 1.0 -0.4 -1.0
Financial difficulties in last 2 years 0.5 0.7 1.3 0.2 1.2
Mouth/teeth dental problems 0.5 0.8 1.1 -1.0 0.7
Heart attack 0.4 0.5 0.8 0.9 0.4
Allergy 0.4 0.9 1.7 0.1 -1.3
Pain all over the body in last month 1.4 1.5 3.0 -1.7 0.2
Diabetes (self-reported) 1.0 1.6 3.0 -1.7 -0.5
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.0 -0.1 -0.2
Medication: Ramipril 0.3 0.4 0.4 0.5 0.7
Medication: Simvastatin 1.5 2.1 3.4 -1.8 -1.0
Fluid intelligence score 0.6 1.2 1.9 0.7 -1.4
Illnesses of siblings 0.0 0.0 0.1 0.1 -0.2
Neuroticism score 0.9 1.8 3.6 0.3 1.9
Weight 0.4 1.7 2.8 0.8 -1.7
Impedance of arm (right) 0.3 1.5 3.0 0.1 1.7
Arm fat percentage (right) 0.1 0.3 0.7 -0.8 -0.1
Trunk fat-free mass 0.5 2.9 3.4 1.8 -1.6
Hip circumference 0.2 1.0 1.6 0.6 -1.3
Time employed in main current job 1.4 1.6 2.1 -1.0 -1.5
Alcohol intake versus 10 years previously 2.2 3.3 3.7 -1.9 1.7
Father’s age at death 0.4 0.5 0.9 -0.2 -1.0
Worrier / anxious feelings 0.1 0.2 0.5 0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 3.7 6.0 6.7 -2.6 2.3
Falls in the last year 0.3 0.5 0.7 -0.8 0.5
Hair/balding pattern: Pattern 3 1.0 1.5 1.6 -1.2 1.3
Number of live births 0.3 0.4 0.5 0.7 0.6
Forced expiratory volume in 1-second (FEV1) 1.4 4.7 9.2 3.0 0.4
Pulse rate 1.1 1.8 2.2 1.2 1.5
Happiness 0.1 0.2 0.3 0.1 -0.6
Noisy workplace 1.9 2.3 4.0 2.0 0.8
Qualifications: A levels/AS levels or equivalent 1.2 2.7 3.3 -1.8 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.4 -0.6 -0.5
Mouth/teeth dental problems: Dentures 0.1 0.1 0.3 0.1 -0.5
Asthma 1.4 2.8 3.6 -1.4 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 -0.1 -0.0
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.7 0.0
Depression (self-reported) 0.2 0.2 0.4 -0.6 0.1
Medication: Lansoprazole 1.0 1.2 2.2 -0.4 1.5
Prospective memory result 0.2 0.2 0.3 0.3 0.5
Lung cancer (father) 3.8 4.4 8.8 -0.2 3.0
Illnesses of mother 0.2 0.3 0.5 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.8 9.6 3.1 -0.3
Pulse wave Arterial Stiffness index 0.7 0.8 0.9 0.9 0.9
Impedance of arm (left) 0.1 0.6 1.2 0.2 1.1
Arm fat mass (right) 0.1 0.3 0.5 -0.2 -0.7
Trunk predicted mass 0.5 3.1 3.5 1.9 -1.6
Standing height 0.6 6.2 9.4 3.1 -1.8
Length of working week for main job 0.5 0.5 0.6 0.6 0.8
Exposure to tobacco smoke at home 3.2 3.6 5.8 -1.2 -2.4
Breastfed as a baby 0.4 0.5 0.9 -0.0 -0.9
Tense / ‘highly strung’ 1.7 2.8 5.4 0.5 2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.1 0.4 0.4
Hair/balding pattern: Pattern 4 1.5 3.7 7.3 -2.7 -0.2
Birth weight of first child 2.2 4.0 7.9 2.8 -0.1
Peak expiratory flow (PEF) 0.5 1.2 1.7 1.3 -0.8
Pulse wave reflection index 0.3 0.4 0.4 -0.6 0.6
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 -0.4 0.1
Loud music exposure frequency 1.0 1.0 1.2 -0.9 -1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.2 -0.3 0.5
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 3.8 1.9 -0.1
Blood clot in the leg (DVT) 0.0 0.0 0.0 0.1 -0.0
Medication: Paracetamol 0.2 0.3 0.4 0.4 0.6
Headache pain in last month 2.5 4.3 8.1 0.7 2.9
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 1.9 1.1 -1.4
Glaucoma (self-reported) 0.1 0.2 0.2 -0.5 0.3
Gout (self-reported) 1.9 2.6 4.4 -0.9 -2.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 0.8 0.3 0.9
Medication: Amlodipine 0.8 1.1 1.2 -1.0 1.1
Medication: Ventolin 100micrograms inhaler 1.8 2.4 2.9 -1.3 1.7
Birth weight 0.5 1.0 2.1 1.4 0.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.5 0.7 -0.5
High blood pressure (siblings) 1.0 1.4 1.6 -1.1 -1.3
Forced vital capacity (FVC), Best measure 2.5 9.1 18.1 4.2 -0.2
Body fat percentage 0.1 0.2 0.4 -0.1 -0.6
Leg fat percentage (right) 0.1 0.2 0.3 -0.5 -0.5
Arm fat-free mass (right) 0.6 3.1 3.2 1.8 -1.7
Exposure to tobacco smoke outside home 0.3 0.4 0.6 -0.5 0.8
Comparative body size at age 10 0.1 0.2 0.3 0.6 0.1
Number of full brothers 0.4 0.5 0.8 -0.9 0.5
Worry too long after embarrassment 1.9 3.2 6.0 0.6 2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 7.1 0.7 2.7
Wheeze or whistling in the chest in last year 0.8 1.5 1.6 -1.2 1.3
Number of children fathered 0.7 0.8 1.5 -1.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 5.1 0.4 2.2
Age at first live birth 0.1 0.1 0.2 0.2 -0.5
Pulse wave peak to peak time 0.7 0.9 1.1 -0.8 -1.1
Health satisfaction 0.4 0.6 0.7 -0.6 0.8
Shortness of breath walking on level ground 0.5 0.6 0.8 -0.9 0.6
Qualifications: College or University degree 0.0 0.1 0.1 -0.2 0.3
Eye problems/disorders: None of the above 1.8 2.0 3.3 -1.8 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.7 0.8 -0.2
Emphysema/chronic bronchitis 0.6 0.7 1.1 -0.5 1.0
Medication for pain relief, constipation, heartburn 1.1 1.8 2.3 1.1 -1.5
Neck or shoulder pain in last month 0.4 0.6 0.8 0.9 0.6
Medication: Blood pressure 1.0 1.8 3.4 -0.4 1.9
Angina (self-reported) 0.6 0.8 1.4 -0.5 1.2
Migraine (self-reported) 0.9 1.1 1.2 1.0 1.1
Medication: Ibuprofen 0.1 0.1 0.2 0.4 -0.0
Medication: Allopurinol 1.3 1.7 2.5 -1.6 -1.0
Medication: Omeprazole 1.1 1.3 2.5 -0.4 1.6
Medication: Seretide 50 evohaler 2.5 2.8 5.2 -2.3 0.7
Mean time to correctly identify matches 0.1 0.2 0.4 0.2 -0.7
Heart disease (mother) 0.2 0.3 0.4 -0.6 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 -0.4 -0.1
Whole body fat mass 0.2 0.8 1.6 0.3 -1.3
Leg fat mass (right) 0.3 1.3 2.4 0.4 -1.5
Arm predicted mass (right) 0.7 3.6 4.2 2.0 -1.8
Pulse rate, automated reading 0.4 1.2 1.9 1.4 0.6
Alcohol intake frequency. 0.7 1.5 2.5 -1.6 -0.8
Comparative height size at age 10 0.1 0.6 1.0 -0.5 -1.0
Number of full sisters 0.2 0.3 0.5 0.0 -0.7
Suffer from ‘nerves’ 1.2 1.9 2.0 -1.4 1.4
Overall health rating 0.9 2.0 4.0 -2.0 0.0
Chest pain or discomfort 1.4 2.1 3.2 -1.8 1.0
Had major operations 2.4 2.8 5.5 0.2 2.3
Age at last live birth 0.5 0.7 1.3 1.1 0.1
Family relationship satisfaction 0.7 0.9 1.8 -1.3 0.2
Leg pain on walking 1.9 2.4 4.8 2.2 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 0.2 0.5
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 0.3 0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 0.9 0.9 -0.7
Medication: Aspirin 1.4 1.8 3.2 -0.6 1.8
Supplements: Vitamin C 0.0 0.0 0.0 -0.1 -0.0
Knee pain experienced in last month 0.5 0.7 0.9 -0.9 0.8
Hypertension (Self-reported) 0.7 1.9 2.7 -1.1 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 0.8 0.9 0.9
Illnesses of father: Heart disease 0.5 0.7 1.4 -1.2 0.1
Illnesses of siblings: Diabetes 0.3 0.4 0.5 -0.7 0.5
Smoking status: Previous 0.6 0.9 1.7 0.5 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.0 1.7 -0.2
Whole body fat-free mass 0.6 3.3 3.5 1.9 -1.8
Leg fat-free mass (right) 0.5 2.7 2.9 1.7 -1.6
Arm fat percentage (left) 0.0 0.2 0.2 -0.5 -0.3
Average weekly red wine intake 1.1 1.6 1.7 1.2 1.3
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.0 0.1
Mood swings 0.8 1.4 2.9 0.0 1.7
Loneliness, isolation 0.2 0.3 0.5 0.7 0.0
Long-standing illness, disability or infirmity 1.6 2.5 3.9 -2.0 1.0
Ever had bowel cancer screening 0.5 0.6 0.6 0.8 0.7
Diabetes diagnosed by doctor 1.0 1.7 3.3 -1.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.3 0.3 1.2
Friendships satisfaction 0.1 0.1 0.3 0.5 -0.0
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.1 0.7
Commuting to job workplace: Walk 0.4 0.5 0.7 0.9 -0.4
Eye problems/disorders: Cataract 1.1 1.2 2.3 1.5 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 0.8 0.1
Medication for cholesterol 0.7 1.0 1.2 1.1 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.1 -1.5 0.6
Back pain experienced in last month 0.3 0.4 0.5 0.7 0.6
Mineral and other dietary supplements 0.5 0.7 0.9 -0.7 -1.0
Breast cancer (self-reported) 1.6 2.0 3.7 -0.5 1.9
Asthma (self-reported) 1.2 2.4 3.6 -1.1 1.9
Osteoporosis (self-reported) 0.6 0.7 1.1 -1.1 -0.5
Osteoarthritis (self-reported) 0.5 0.7 0.7 0.8 -0.8
Medication: Aspirin 1.6 2.1 4.1 -0.4 2.0
Medication: Gliclazide 1.0 1.1 2.1 -1.5 0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 1.3 1.1 -1.0
Smoking status: Current 0.7 1.1 1.8 -1.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.9 1.4 0.2
Whole body water mass 0.6 3.2 3.3 1.8 -1.8
Leg predicted mass (right) 0.5 2.7 2.8 1.6 -1.7
Arm fat mass (left) 0.1 0.3 0.6 -0.1 -0.8
Number of self-reported non-cancer illnesses 0.3 0.6 1.2 -0.0 1.1
Average weekly champagne plus white wine intake 0.5 0.6 1.1 0.5 -1.0
Miserableness 0.6 1.0 2.0 0.3 1.4
Guilty feelings 0.4 0.7 1.2 0.4 1.1
Wears glasses or contact lenses 0.6 0.7 1.3 1.1 -0.4
Ever taken oral contraceptive pill 2.1 2.4 3.6 -1.9 -1.1
Hearing aid user 0.3 0.3 0.4 -0.4 0.6
Mother’s age at death 0.0 0.1 0.1 0.3 -0.0
Financial situation satisfaction 1.0 1.2 2.4 0.1 1.5
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 -0.8 0.1
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.3 0.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.5 0.2
Medication: Blood pressure 0.2 0.4 0.4 -0.6 0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.4 0.5 0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.0 0.5 1.0
High cholesterol (Self-reported) 0.8 1.4 1.4 -1.1 1.2
Medication: Bendroflumethiazide 0.9 1.4 1.7 -1.0 1.3
Medication: Paracetamol 1.6 2.5 3.3 1.3 1.8
Medication: Lisinopril 1.2 1.5 3.0 -1.7 0.2
Medication: Atorvastatin 0.5 0.6 0.7 -0.7 0.8
Illnesses of father: High blood pressure 1.4 1.7 3.3 -1.8 -0.4
Alcohol drinker status: Never 0.6 0.7 1.3 -1.1 -0.4
Ever smoked 0.2 0.3 0.4 0.7 0.4
Basal metabolic rate 0.5 2.8 3.1 1.6 -1.8
Leg fat percentage (left) 0.1 0.3 0.3 -0.6 -0.5
Arm fat-free mass (left) 0.4 2.1 2.6 1.3 -1.6
Number of operations (self-reported) 0.5 0.8 1.0 1.0 0.8
Average weekly beer plus cider intake 2.7 3.9 7.3 -0.6 -2.7
Irritability 0.4 0.7 1.2 0.4 -1.1
Risk taking 0.4 0.5 0.6 -0.8 -0.7
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.3 0.0 0.6
Fractured/broken bones in last 5 years 0.9 1.2 1.9 1.4 -0.7
Age started oral contraceptive pill 1.3 1.6 2.8 1.7 -0.6
Diastolic blood pressure, automated reading 0.4 1.2 1.8 -1.4 -0.8
Ever depressed for a whole week 1.0 1.3 2.1 -1.4 -0.7
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.5 -0.2
Commuting to job workplace: Cycle 0.3 0.3 0.6 -0.8 0.2
Myopia 0.4 0.6 0.9 -0.7 -0.9
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.5 1.0 -1.6
Cholesterol lowering medication 1.7 2.5 5.1 -2.2 0.1
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 3.7 -0.6 1.9
Pain experienced in last month 0.7 1.1 1.1 -1.1 -1.1
Supplements: Calcium 0.3 0.3 0.5 0.7 0.4
Basal cell carcinoma (self-reported) 0.6 0.7 1.0 1.0 0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.6 0.8 0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.2 0.3 0.5
Heart disease (siblings) 0.6 0.8 1.3 1.2 0.4
Alcohol drinker status: Previous 0.0 0.0 0.0 -0.2 0.1
Pack years of smoking 1.4 2.1 4.1 2.0 -0.3
Impedance of whole body 0.2 1.0 1.9 0.2 1.4
Leg fat mass (left) 0.3 1.2 2.2 0.4 -1.5
Arm predicted mass (left) 0.4 2.3 2.9 1.3 -1.7