Best TWAS P=4.3e-30 · Best GWAS P=1.48e-43 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | ARRB2 | 0.29 | 0.08 | enet | 14 | 0.19 | 1.0e-06 | -6.9 | -5.8 | 6.0e-09 | 0.30 | 0.50 | 0.09 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | AC012146.7 | 0.26 | 0.20 | lasso | 4 | 0.17 | 1.2e-12 | 3.5 | -5.3 | 8.8e-08 | 0.01 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Esophagus Mucosa | KIF1C | 0.10 | 0.00 | enet | 37 | 0.02 | 2.4e-02 | -1.7 | -6.9 | 3.9e-12 | 0.45 | 0.01 | 0.88 | TRUE |
| 4 | GTEx | Heart Left Ventricle | ARRB2 | 0.21 | 0.14 | lasso | 10 | 0.14 | 1.2e-07 | -6.9 | 8.4 | 2.9e-17 | -0.44 | 0.99 | 0.01 | TRUE |
| 5 | GTEx | Lung | ARRB2 | 0.14 | 0.10 | enet | 15 | 0.11 | 1.6e-08 | -11.2 | -9.8 | 1.5e-22 | 0.38 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Testis | ZMYND15 | 0.34 | 0.00 | enet | 40 | 0.04 | 7.9e-03 | 1.6 | 5.2 | 1.8e-07 | -0.05 | 0.06 | 0.06 | TRUE |
| 7 | GTEx | Whole Blood | ARRB2 | 0.10 | 0.12 | lasso | 1 | 0.12 | 8.2e-11 | -9.8 | -9.8 | 1.8e-22 | 0.48 | 1.00 | 0.00 | FALSE |
| 8 | METSIM | Adipose | SLC25A11 | 0.07 | 0.00 | blup | 438 | 0.02 | 1.2e-03 | 3.1 | -8.0 | 1.1e-15 | 0.27 | 0.08 | 0.37 | TRUE |
| 9 | NTR | Blood | ALOX15 | 0.13 | 0.18 | bslmm | 435 | 0.18 | 8.7e-55 | -11.2 | 11.4 | 4.3e-30 | -0.45 | 1.00 | 0.00 | TRUE |
| 10 | NTR | Blood | ARRB2 | 0.04 | 0.03 | lasso | 3 | 0.03 | 2.6e-09 | -10.2 | -10.1 | 7.4e-24 | 0.47 | 0.98 | 0.02 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | PELP1 | 0.08 | 0.06 | lasso | 6 | 0.05 | 4.0e-07 | -7.3 | 7.4 | 1.9e-13 | -0.42 | 1.00 | 0.00 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | ALOX15 | 0.18 | 0.21 | lasso | 5 | 0.22 | 1.3e-27 | -7.3 | -9.2 | 4.4e-20 | 0.46 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | ARRB2 | 0.06 | 0.05 | enet | 26 | 0.05 | 1.5e-15 | -11.2 | -9.9 | 4.6e-23 | 0.44 | 1.00 | 0.00 | TRUE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ALOX15 | 0.06 | 0.00 | blup | 50 | 0.02 | 3.5e-03 | -13.8 | 9.1 | 6.7e-20 | -0.64 | 0.00 | 0.71 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARRB2 | 0.01 | 0.02 | lasso | 2 | 0.01 | 4.8e-03 | -7.3 | -8.3 | 1.5e-16 | 0.44 | 0.01 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf107 | 0.05 | 0.02 | blup | 41 | 0.04 | 7.0e-09 | 3.8 | 5.9 | 4.3e-09 | 0.03 | 0.75 | 0.20 | TRUE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ALOX15 | 0.10 | 0.05 | lasso | 5 | 0.05 | 1.8e-06 | -6.9 | -8.1 | 6.8e-16 | 0.42 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MED11 | 0.05 | 0.04 | enet | 8 | 0.04 | 5.5e-05 | 4.5 | -7.5 | 9.7e-14 | 0.18 | 0.21 | 0.12 | TRUE |
| 19 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZMYND15 | 0.19 | 0.02 | blup | 54 | 0.04 | 6.2e-03 | 4.5 | -6.9 | 5.2e-12 | 0.22 | 0.01 | 0.29 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | PELP1 | 0.05 | 0.05 | lasso | 2 | 0.04 | 2.1e-04 | -11.2 | 11.0 | 2.3e-28 | -0.46 | 0.19 | 0.20 | FALSE |