Hub : Genes

SLC25A11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1490	0.0640	4.5e-03	-0.004	NA	0.006	NA	-0.003	5.8e-01	NA	1.4e-01	NA	4.9e-01
2	GTEx	Artery Tibial	0.0897	0.0409	8.6e-03	0.020	NA	0.034	NA	0.030	1.0e-02	NA	1.0e-03	NA	1.8e-03
3	GTEx	Thyroid	0.0850	0.0370	8.2e-03	0.050	NA	0.004	NA	0.023	9.9e-05	NA	1.6e-01	NA	6.4e-03
4	METSIM	Adipose	0.0731	0.0250	3.3e-04	0.002	0.017	0.002	0.015	0.002	1.2e-01	1.2e-03	1.2e-01	2.2e-03	1.3e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.2307	0.0401	0.0e+00	0.232	0.212	0.247	0.234	0.238	2.2e-29	1.0e-26	1.7e-31	1.2e-29	2.9e-30
6	YFS	Blood	0.0604	0.0156	5.0e-10	0.022	0.030	0.041	0.044	0.034	9.7e-08	3.3e-10	1.8e-13	3.5e-14	2.0e-11
7	TCGA	Rectum Adenocarcinoma	0.5670	0.1390	6.1e-03	0.022	0.096	0.111	NA	0.120	9.8e-02	3.1e-03	1.5e-03	NA	9.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.3	4.1	2.0	-0.4	1.6	-0.4	-1.2	-0.7	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	1.2	0.7	1.4	-0.6	-0.2	-0.1	-1.0
Depressed Affect (Nagel 2018)	1.0	2.2	6.1	1.8	-0.1	-1.2	2.5	-1.6	1.4	-0.4
Depression (Nagel 2018)	2.0	3.0	7.9	2.1	0.6	-0.5	2.8	-2.3	1.5	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.5	-0.0	-1.8	0.1	-1.7	1.9	-1.2	0.2
Neuroticism (Nagel 2018)	1.0	2.4	6.9	2.6	-0.3	-1.8	1.2	-1.6	1.6	-0.2
Schizophrenia (2018)	0.3	0.6	1.8	-0.0	1.2	0.5	-0.5	0.7	0.5	-1.3
Schizophrenia vs Biploar Disorder	1.4	1.9	5.0	0.7	0.0	-0.6	1.7	-2.2	1.9	0.9
Worry (Nagel 2018)	1.4	2.9	7.3	2.2	-0.1	-1.5	1.5	-2.7	1.7	0.5
Alzheimer’s Disease (in mother)	1.2	1.4	4.6	0.8	0.5	2.1	0.4	0.5	1.3	-1.4
Alzheimer’s Disease (in father)	1.3	1.4	3.7	1.7	1.1	1.9	0.8	-1.1	-0.6	0.0
Alzheimer’s Disease (including proxy)	2.0	2.9	13.2	1.8	1.0	3.6	0.4	-0.1	0.8	-1.5
Crohns Disease (2017)	0.9	2.0	4.7	2.2	-1.2	1.8	1.7	0.5	1.0	-0.7
Irritable Bowel Disease (IBD)	1.4	3.3	8.1	2.4	-0.2	0.7	2.9	-1.0	2.3	-1.6
Ulcerative Colitis (UC)	1.9	3.6	7.7	1.2	0.8	-0.5	2.7	-2.5	2.8	-1.2
Major Depression (MDD)	0.1	0.2	1.1	0.0	-0.1	1.0	-0.2	-0.2	0.0	-0.1
Reaction Time	1.0	2.0	3.9	0.3	2.0	1.6	0.5	-1.9	-1.6	1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.5	7.3	-0.6	-1.6	0.8	-1.8	2.7	-1.9	0.1
Breast Cancer	0.6	1.5	3.5	-1.8	0.1	-1.6	0.0	0.6	1.9	-0.9
Ovarian Cancer	0.9	1.2	2.6	-1.2	0.2	1.6	-1.5	-1.0	-0.6	-0.5
Prostate Cancer	0.3	0.4	1.6	-0.6	0.5	1.3	0.4	0.1	-0.2	-0.5
Age at First Birth	0.5	0.7	2.3	0.0	1.2	0.4	-0.2	-1.0	1.5	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.9	-1.0	-0.2	2.0	-1.0	1.2	-1.6	0.0
Coronary Artery Disease (CAD)	1.2	1.4	7.7	-0.1	0.0	-1.2	0.4	-0.5	2.8	0.0
Crohns Disease (2012)	0.5	0.7	4.2	0.2	-0.2	2.0	-0.3	0.4	-0.5	0.6
Mean Putamen Volume	1.0	1.1	2.8	-1.2	-1.2	0.5	-1.7	0.4	-1.0	0.9
Fasting Glucose	1.3	1.6	3.1	0.6	0.1	1.5	-1.6	0.3	-1.7	1.8
HbA1C	4.4	4.9	17.9	-0.8	-4.2	-0.9	-1.6	3.3	-1.1	0.6
HDL Cholesterol	0.2	0.3	1.1	-1.1	-0.3	0.3	-0.2	-0.6	0.2	0.0
LDL Cholesterol	1.5	2.4	5.0	1.4	-2.2	-1.6	1.5	-0.7	2.1	0.0
Lupus	2.2	3.3	8.0	-1.4	-2.1	-2.3	-1.2	2.8	-0.7	-1.3
Neuroticism (2016)	1.9	2.8	6.8	1.6	1.6	-0.4	2.5	-2.6	0.8	-0.5
Primary Biliary Cirrhosis	1.0	1.4	4.0	2.0	-0.5	-1.6	1.2	-0.5	1.2	-0.2
Rheumatoid Arthritis	2.2	3.1	6.9	-1.3	-2.4	-0.6	-0.4	2.6	-1.3	-2.2
Schizophrenia (2014)	0.5	1.0	2.7	1.3	1.6	0.2	0.4	-0.9	1.1	-0.6
Triglycerides	0.2	0.3	0.9	0.3	0.1	0.0	-0.8	0.5	-1.0	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.1	-0.5	0.0	-0.5	-0.8	0.4	-1.8	0.0
Ulcerative Colitis	3.4	5.0	8.9	2.8	1.3	-0.5	3.0	-2.6	2.8	-1.2
Blood Eosinophil Count	1.7	13.0	64.2	0.3	2.5	-1.4	-8.0	3.1	-0.9	2.8
Blood Platelet Count	7.7	88.8	252.8	0.7	0.5	10.1	-1.5	-6.2	-15.9	15.0
Blood Red Count	0.4	3.5	8.8	-1.0	2.8	3.0	2.0	-1.7	-0.2	-0.1
Blood White Count	1.5	11.2	34.2	-0.4	-2.5	5.8	-0.4	2.5	-5.3	-1.6
Heel T-Score	0.3	2.3	10.2	1.7	0.7	0.2	1.4	0.5	0.4	-3.2
BMI	1.2	7.1	33.9	1.1	-1.3	5.8	0.5	1.6	-3.1	-0.6
Height	0.3	6.7	16.2	1.8	3.4	-1.1	3.4	-4.0	1.8	0.5
Waist Hip Ratio (WHR)	0.6	2.7	7.8	-0.4	0.7	-1.6	2.3	-0.6	2.8	-1.5
Systolic Blood Pressure	0.3	1.7	8.6	0.1	-0.3	-0.9	0.7	0.8	1.2	-2.9
Smoking Status	1.8	4.3	14.2	-0.8	-2.1	-0.9	-2.0	3.8	0.7	-2.3
Allergy or Eczema	0.4	1.1	2.2	-0.0	1.3	1.2	-0.9	0.2	-1.5	1.2
Cardiovascular Disease	0.6	1.8	5.0	0.3	-1.2	0.3	-1.0	2.2	1.4	-1.8
Hypothyroidism (self reported)	1.5	3.4	9.8	-0.1	-2.0	1.2	-1.8	2.3	-3.1	-0.5
Respiratory disease	0.8	1.7	4.8	1.2	-1.6	-0.2	-1.3	0.8	-1.1	2.2
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.7	0.0	-1.5	1.7	-2.6	2.6	-1.0	-0.4
Lung FEV1/FVC ratio	0.2	1.0	2.9	1.4	0.7	1.7	0.6	-0.4	0.6	-0.8
Lung FVC	0.4	2.3	6.4	-0.8	-1.2	-0.2	-2.5	1.8	-1.9	0.6
Neuroticism	1.0	2.4	5.7	2.4	-1.3	-1.4	1.7	-0.8	1.8	-0.6
Chronotype (morning person)	0.7	1.7	5.8	1.4	-0.1	-1.8	-0.5	-0.8	-0.4	2.4
Hair Pigment	0.0	0.9	3.3	-0.1	-0.2	0.4	-0.6	1.2	1.8	-0.9
Tanning	0.1	1.5	3.3	-1.5	-1.8	1.0	-0.1	0.6	-0.6	1.8
Hand grip strength (left)	0.1	0.4	1.7	-1.3	-0.4	0.3	-0.4	0.7	-0.3	-0.2
Number of treatments/medications taken	0.6	1.1	2.5	0.0	-1.2	0.5	-1.2	1.6	-1.3	-0.4
Average weekly spirits intake	1.7	2.1	5.1	2.3	-0.9	1.4	-1.1	0.3	-1.6	1.7
Sensitivity / hurt feelings	0.7	1.3	6.4	2.5	-0.6	-0.9	-0.5	0.2	-0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	1.3	-0.4	-0.6	1.4	-0.8	1.2	1.1
Hearing difficulty/problems: Yes	1.0	1.5	5.8	2.4	0.4	-0.5	1.5	-0.6	-0.6	1.2
Relative age of first facial hair	0.4	0.8	2.6	-0.3	0.0	-1.6	-0.6	0.4	1.3	-0.9
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.5	0.6	-1.1	1.8	-1.7	1.5	-1.9	-0.5
Ever used hormone-replacement therapy (HRT)	1.4	1.8	7.1	1.4	-2.7	-1.6	0.1	0.9	-0.4	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-1.3	0.0	0.5	0.7	-1.3	0.4	0.5
Systolic blood pressure, automated reading	0.5	1.4	3.6	0.1	-1.0	-1.2	0.5	1.9	-0.1	-1.8
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	7.3	0.0	0.3	2.7	-2.4	0.4	-1.1	0.6
Angina	0.2	0.3	0.8	0.5	-0.4	0.8	0.1	-0.2	-0.9	-0.0
Medication for hormone replacement therapy	1.2	1.3	2.9	-0.3	-1.0	0.9	-1.4	1.5	-0.6	1.7
Vitamin and mineral supplements	0.4	0.6	2.0	-0.5	-0.2	-0.1	-0.5	1.3	-0.2	1.4
Supplements: Zinc	0.4	0.4	1.3	-0.2	-0.8	0.9	-0.1	-0.3	-0.5	1.1
Medication: Co-codamol	1.3	1.5	4.3	1.5	0.1	-0.4	2.1	-0.8	0.3	1.8
Medication: Metformin	2.3	3.2	10.8	0.8	-0.5	1.2	-3.3	1.6	-2.6	0.4
Diabetes (father)	0.5	0.6	3.5	0.4	0.7	0.1	-1.9	-0.1	-0.2	0.1
Diabetes (mother)	0.4	0.5	1.8	1.1	0.2	-1.3	0.0	0.0	0.1	0.5
Severe depression (siblings)	0.5	0.5	1.0	-0.0	-1.0	1.0	-0.9	-0.5	-0.3	0.6
Pack years adult smoking proportion	0.9	1.3	3.4	-0.3	-1.9	-0.0	0.8	0.4	1.4	-1.7
Impedance of leg (right)	0.5	2.3	6.4	-0.5	1.6	-2.5	0.0	-1.5	1.9	-1.0
Leg fat-free mass (left)	0.7	3.4	15.8	0.7	-0.1	4.0	0.6	0.8	-2.6	0.5
Trunk fat percentage	1.2	4.6	15.3	1.5	-0.7	3.5	-0.6	1.2	-3.9	0.1
Hand grip strength (right)	0.4	1.0	4.3	-1.2	0.5	2.1	0.6	-0.7	-0.3	0.0
Townsend deprivation index at recruitment	0.6	0.8	1.8	-1.0	-0.6	-0.6	0.4	0.4	1.3	-1.4
Current tobacco smoking	1.3	2.1	7.5	-1.1	-0.4	-0.3	-2.1	2.7	-0.4	-0.8
Average weekly fortified wine intake	2.3	2.7	4.9	1.4	1.7	2.1	0.7	-1.9	-2.2	0.6
Maternal smoking around birth	1.0	1.4	5.5	-0.8	0.3	0.5	1.2	1.3	0.5	-2.3
Fed-up feelings	1.1	2.1	4.3	1.2	0.4	-0.1	2.0	-1.1	2.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	7.7	2.8	1.3	-0.6	2.1	-1.2	1.5	-0.5
Relative age voice broke	1.7	2.7	9.7	0.1	0.8	-3.1	0.6	0.0	2.5	-1.4
Taking other prescription medications	1.4	2.1	6.2	0.2	-1.6	-0.8	-2.1	2.5	-1.0	-0.3
Age when periods started (menarche)	1.5	3.7	14.9	1.2	-1.0	-3.9	0.2	0.8	2.7	-0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	0.3	0.9	1.0	1.1	-1.4	0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	0.3	0.6	-1.1	0.7	0.8	1.1	0.3
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.9	-0.1	1.7	1.9	-0.6	-0.5	-0.7	-2.0
Qualifications: CSEs or equivalent	1.3	1.7	3.6	-0.1	-1.7	1.4	-1.7	1.9	-0.2	-0.8
Serious illness, injury or assault to yourself	1.4	1.6	7.6	-0.4	-0.7	2.8	-0.4	0.8	-1.2	-1.0
High blood pressure	0.2	0.6	1.7	-0.4	0.8	-0.9	-0.1	1.0	0.5	-1.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.5	-0.5	0.7	1.7	-0.2	-0.6	-1.9	1.8
Multivitamins +/- minerals	1.1	1.4	6.8	0.6	0.6	0.7	1.3	-2.6	0.0	-0.2
Stomach or abdominal pain in last month	0.9	1.1	3.2	0.5	-0.9	0.8	-1.5	0.4	-1.8	-0.4
Supplements: Glucosamine	0.8	1.1	5.1	0.4	-0.3	0.8	0.2	-0.9	-2.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	-0.8	-0.4	0.7	-0.5	0.5	-0.3	-0.1
Medication: Atenolol	2.6	3.3	8.1	2.2	2.0	0.1	2.0	-2.9	1.2	0.2
Medication: Levothyroxine sodium	2.2	3.7	7.9	0.2	-2.3	1.9	-1.4	2.7	-2.8	-0.2
Sitting height	0.2	1.2	4.0	0.8	1.2	0.3	2.0	-1.4	-0.6	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.9	1.7	-0.6	0.2	-0.4	-0.3	-0.4	0.6
High blood pressure (mother)	0.3	0.4	1.2	-0.4	-0.3	-1.1	-0.3	0.4	-1.0	-0.4
Body mass index (BMI)	1.4	6.0	19.5	1.8	-1.6	4.4	-0.0	2.0	-3.5	0.1
Impedance of leg (left)	0.5	2.3	6.1	-0.4	1.8	-2.5	-0.0	-1.7	1.8	-0.9
Leg predicted mass (left)	0.6	3.3	15.1	0.6	-0.2	3.9	0.6	0.9	-2.5	0.4
Trunk fat mass	1.2	5.0	15.9	1.8	-0.5	4.0	-0.1	1.2	-3.8	0.1
Waist circumference	0.9	3.3	10.6	1.5	-1.0	3.3	0.3	1.4	-2.7	0.1
Number of incorrect matches in round	0.5	0.9	3.3	0.3	1.8	-1.0	0.7	-1.0	-0.3	0.3
Past tobacco smoking	2.3	4.2	11.2	0.5	2.6	1.8	1.8	-3.3	-0.4	2.1
Alcohol usually taken with meals	1.0	1.6	3.3	-1.0	1.6	-0.4	1.5	-1.8	-1.4	0.3
Nervous feelings	0.5	1.0	2.7	0.4	-0.5	-1.3	-0.5	-1.3	0.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	8.8	1.4	2.1	0.1	1.2	-3.0	0.7	0.7
Hearing difficulty/problems with background noise	2.2	3.5	13.3	3.7	0.5	-0.2	2.9	-1.2	1.1	0.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.9	-0.2	0.5	0.5	-0.3	0.5	0.9	-0.7
Had menopause	0.2	0.3	0.8	-0.1	0.1	-0.9	-0.5	-0.1	-0.8	-0.6
Had other major operations	0.5	0.6	2.1	-0.3	-1.0	-0.8	1.5	0.2	0.3	0.8
Forced vital capacity (FVC)	0.2	0.6	1.5	-0.0	1.2	-0.1	0.6	-0.1	1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.7	1.2	0.6	-1.1	1.3	0.3	1.3	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.6	-0.3	-0.1	0.4	0.4	-1.1	1.6	-0.8
Qualifications: None of the above	0.4	0.9	3.3	1.0	0.2	-1.8	0.2	0.9	0.6	-1.1
Financial difficulties in last 2 years	1.1	1.4	2.9	1.6	1.3	1.3	0.5	-0.9	-0.1	-1.7
Mouth/teeth dental problems	0.7	1.1	2.9	-0.6	0.2	-0.3	-1.7	0.8	1.3	-1.6
Heart attack	0.2	0.3	0.8	0.1	0.0	-0.9	-0.5	-0.3	0.6	0.6
Allergy	1.2	2.7	9.5	-0.3	0.1	-1.4	1.2	-0.0	3.1	-2.5
Pain all over the body in last month	3.0	3.2	8.4	1.1	-0.1	2.6	-0.8	-1.4	-1.8	2.9
Diabetes (self-reported)	1.2	1.8	5.3	0.1	-0.4	1.5	-2.3	1.8	-1.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.9	-1.3	0.5	0.5	-1.4	0.0	-0.6	0.4
Medication: Ramipril	0.5	0.7	1.5	0.4	0.9	0.5	-1.2	0.8	-0.8	-0.8
Medication: Simvastatin	0.5	0.8	2.2	1.1	-0.6	-0.5	-0.3	0.1	1.2	-1.5
Fluid intelligence score	0.4	0.8	1.9	-1.1	-0.7	1.4	-0.2	0.5	-1.0	0.9
Illnesses of siblings	0.3	0.5	1.1	-0.1	1.0	0.7	-0.4	-0.5	1.1	0.6
Neuroticism score	0.7	1.5	3.3	1.5	-1.5	-0.8	1.0	-0.4	1.8	-0.9
Weight	0.9	4.4	17.6	1.9	0.1	4.2	0.9	0.7	-2.9	0.1
Impedance of arm (right)	0.5	2.4	4.7	-1.5	1.6	-2.2	-0.7	-1.9	0.6	1.7
Arm fat percentage (right)	1.5	6.0	17.0	1.6	-1.5	4.1	-1.2	1.9	-3.9	0.6
Trunk fat-free mass	0.4	2.2	10.3	0.9	0.8	3.2	1.7	-0.1	-0.6	-0.3
Hip circumference	1.3	5.5	17.7	1.8	-0.7	4.2	-0.3	1.1	-4.0	0.3
Time employed in main current job	0.9	1.1	3.0	1.7	-1.1	-0.3	1.0	0.2	1.0	-1.2
Alcohol intake versus 10 years previously	0.7	1.0	3.2	0.7	-0.4	0.1	1.8	-1.1	1.1	-0.8
Father’s age at death	1.4	1.9	5.2	0.3	1.1	0.1	2.0	-2.3	1.4	0.8
Worrier / anxious feelings	0.8	1.5	4.7	2.2	-0.7	-0.6	1.0	-1.7	1.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	4.7	2.2	0.2	0.1	0.9	-0.6	-0.0	0.2
Falls in the last year	1.5	2.1	5.7	2.4	-0.6	0.6	-1.1	1.0	-2.1	-1.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	-0.3	-0.5	1.2	1.0	-0.2	-0.8	-0.1
Number of live births	0.9	1.3	4.5	0.3	-1.1	1.2	-0.1	1.5	-0.1	-2.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.6	-0.2	1.6	0.7	0.9	-0.1	1.2	-0.9
Pulse rate	1.1	1.8	6.9	2.6	1.2	0.3	0.8	-1.5	0.7	0.9
Happiness	1.0	1.2	4.2	-0.7	-1.4	-2.1	-0.2	-0.2	1.1	-0.5
Noisy workplace	1.4	1.7	3.9	1.0	1.5	0.3	2.0	-1.4	1.3	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.1	-0.2	0.6	-0.3	0.4	-0.2	-0.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.3	1.3	-2.1	0.3	0.5	1.7	1.0	-0.0
Mouth/teeth dental problems: Dentures	1.1	1.8	4.4	1.7	-0.4	-0.4	0.6	-0.7	-2.1	2.0
Asthma	1.2	2.3	5.3	0.7	-1.2	-0.4	-2.3	1.9	-2.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	7.1	1.5	-0.2	0.6	2.7	0.4	1.3	-1.9
Medication: Cholesterol lowering	0.4	0.6	1.8	0.2	-0.3	-0.7	-1.3	0.7	0.6	-0.8
Depression (self-reported)	0.5	0.6	1.5	0.0	1.2	0.3	0.4	-1.1	-0.1	1.1
Medication: Lansoprazole	0.1	0.1	0.3	-0.6	-0.3	0.1	-0.5	0.4	-0.3	-0.1
Prospective memory result	1.7	2.1	9.7	3.1	0.0	-1.9	-0.5	0.3	1.0	-0.2
Lung cancer (father)	2.5	2.9	10.8	1.4	1.2	-3.3	2.0	0.8	1.3	0.1
Illnesses of mother	1.1	1.3	4.2	-0.1	0.4	1.9	0.9	-2.1	0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.1	-1.0	1.8	0.1	0.4	-0.4	1.1	-1.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.8	-1.4	0.0	0.5	-0.1	-0.1	-0.9	-0.3
Impedance of arm (left)	0.5	2.1	6.9	-0.8	1.8	-2.6	-0.7	-1.7	0.3	0.9
Arm fat mass (right)	1.4	5.8	20.5	1.9	-1.0	4.5	-0.3	1.5	-3.6	0.4
Trunk predicted mass	0.4	2.1	9.9	1.0	0.8	3.1	1.7	-0.1	-0.6	-0.1
Standing height	0.4	3.7	12.7	0.3	3.6	0.1	2.1	-2.7	0.9	0.1
Length of working week for main job	0.9	1.0	2.4	0.8	-1.4	0.3	0.6	1.6	-0.3	1.3
Exposure to tobacco smoke at home	0.5	0.6	1.5	-0.1	0.6	0.9	-0.5	-1.1	-0.2	1.2
Breastfed as a baby	0.3	0.3	0.9	0.2	-0.4	-0.1	0.9	-0.8	-0.2	0.8
Tense / ‘highly strung’	1.1	1.9	5.9	1.4	0.1	-1.2	0.7	-1.7	2.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.5	1.6	-0.8	1.0	-1.0	-1.2	-0.1	0.6
Hair/balding pattern: Pattern 4	0.9	2.2	7.0	-2.6	-1.6	-1.5	-0.1	1.7	-0.1	-0.7
Birth weight of first child	0.8	1.4	3.8	1.3	1.9	0.8	0.5	-1.5	-0.2	1.0
Peak expiratory flow (PEF)	0.4	1.0	3.5	0.1	1.2	0.0	1.9	-0.1	1.4	-0.6
Pulse wave reflection index	2.3	2.8	5.8	-2.4	-2.0	-0.9	-1.1	2.2	-1.5	1.0
Ever highly irritable/argumentative for 2 days	1.3	1.5	5.0	0.3	0.7	2.2	-0.0	-0.4	1.2	-1.8
Loud music exposure frequency	0.2	0.2	0.4	-0.6	0.6	0.3	-0.2	0.2	0.3	-0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.9	-1.5	-0.7	2.1	-0.6	0.5	-2.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.8	-0.3	0.1	0.5	0.3	-0.6	0.4
Blood clot in the leg (DVT)	1.8	2.3	6.4	-1.2	-1.3	1.1	-1.0	0.9	-2.5	1.9
Medication: Paracetamol	0.9	1.6	4.5	0.6	-2.0	2.1	-0.2	0.8	-0.8	-0.8
Headache pain in last month	0.7	1.3	4.7	2.2	-1.0	0.3	0.4	1.5	0.3	-0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.3	0.1	-0.6	1.5	0.6	-0.9	-0.2	1.4
Glaucoma (self-reported)	1.5	1.8	3.4	-1.7	-0.3	-0.5	-1.8	1.7	1.4	-1.1
Gout (self-reported)	0.8	1.1	2.5	-0.5	-1.6	-0.3	-1.1	1.4	0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	10.5	-0.7	-1.7	2.1	-1.4	1.6	-3.2	-0.0
Medication: Amlodipine	0.8	1.2	6.2	1.3	0.3	-2.5	0.0	-0.0	0.7	-0.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	6.5	2.5	0.3	-0.4	0.3	-0.7	0.8	0.7
Birth weight	1.0	2.2	5.0	1.8	0.6	1.7	1.2	-2.2	0.8	1.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	-0.2	-0.8	-0.3	-0.2	0.9	0.4	0.5
High blood pressure (siblings)	0.6	0.8	1.9	-1.4	-0.5	-0.5	0.2	0.9	-1.1	-1.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.1	-0.7	1.4	-1.2	0.5	-0.4	1.4	-0.9
Body fat percentage	1.3	5.3	16.0	1.7	-1.0	3.7	-0.9	1.6	-4.0	-0.2
Leg fat percentage (right)	1.4	5.1	12.9	1.8	-1.4	3.6	-0.6	2.0	-3.6	-0.6
Arm fat-free mass (right)	0.5	2.7	11.0	1.4	0.1	3.3	1.7	0.6	-1.4	-0.9
Exposure to tobacco smoke outside home	0.4	0.5	1.4	1.0	-0.2	0.2	1.2	0.9	0.4	0.3
Comparative body size at age 10	0.2	0.5	1.8	0.5	-0.2	-0.1	1.2	-0.2	-0.1	1.4
Number of full brothers	0.7	0.9	3.8	-1.0	0.9	1.9	0.8	-0.1	0.1	-0.1
Worry too long after embarrassment	1.0	1.7	7.0	2.6	-1.1	0.0	0.8	-0.7	1.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.1	1.4	-0.7	0.4	0.5	-1.3	-0.1	1.4
Wheeze or whistling in the chest in last year	1.1	2.0	11.7	3.4	1.0	-1.0	0.3	0.0	0.1	-0.3
Number of children fathered	1.7	2.0	4.8	-1.5	-0.8	1.2	-0.2	2.2	-1.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.6	-0.8	1.0	0.3	-1.0	-0.2	0.6
Age at first live birth	0.8	1.4	3.8	-1.0	0.2	-0.6	2.0	-0.0	2.0	-0.5
Pulse wave peak to peak time	0.4	0.5	1.7	1.3	0.2	-0.6	0.5	-0.2	1.1	0.1
Health satisfaction	2.1	2.8	8.5	2.9	0.3	-1.7	1.6	-2.1	0.4	0.9
Shortness of breath walking on level ground	0.6	0.7	2.5	1.6	-0.5	0.4	0.7	-0.8	0.4	-0.8
Qualifications: College or University degree	0.3	1.0	3.2	-1.8	1.7	-0.2	1.0	-0.4	0.2	-0.2
Eye problems/disorders: None of the above	1.9	2.2	8.5	-0.1	0.7	0.5	2.9	-1.9	1.3	0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.9	0.5	0.7	0.6	1.5	-1.7	-0.5	0.3
Emphysema/chronic bronchitis	0.2	0.2	0.8	0.0	0.9	0.2	-0.7	0.2	-0.2	-0.5
Medication for pain relief, constipation, heartburn	1.0	1.8	5.0	-2.2	1.6	-0.6	-0.0	-1.2	0.0	1.7
Neck or shoulder pain in last month	1.6	2.3	11.5	0.1	-1.2	-0.8	0.6	1.4	0.1	-3.4
Medication: Blood pressure	0.6	1.1	2.6	0.0	1.3	-1.6	-0.4	0.7	0.6	-1.6
Angina (self-reported)	0.2	0.3	0.9	0.2	-0.3	0.9	0.0	-0.2	-1.0	0.1
Migraine (self-reported)	0.6	0.8	2.1	-1.4	-0.9	-1.2	0.3	0.7	0.6	-0.2
Medication: Ibuprofen	1.7	2.0	5.6	1.3	-0.2	1.1	2.4	0.3	1.3	-1.9
Medication: Allopurinol	1.6	2.1	5.6	-0.8	-1.1	-0.5	-1.6	2.0	0.8	-2.4
Medication: Omeprazole	0.8	0.9	2.5	1.0	0.6	-0.6	-1.6	0.2	1.4	-0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.7	0.1	-0.6	1.0	-1.3	0.8	-0.7	-0.5
Mean time to correctly identify matches	1.1	2.2	4.0	1.2	1.6	0.9	1.2	-2.0	-1.9	1.1
Heart disease (mother)	1.1	1.3	3.7	-0.5	-0.9	-1.9	-0.4	1.5	0.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.9	-0.9	-1.2	-0.1	1.4	0.5	-0.0	-2.0
Whole body fat mass	1.2	5.2	16.3	1.9	-0.9	4.0	-0.0	1.4	-3.6	-0.2
Leg fat mass (right)	1.6	6.2	20.2	1.5	-1.3	4.5	-0.3	2.0	-3.8	-0.6
Arm predicted mass (right)	0.5	2.7	11.6	1.2	0.1	3.4	1.6	0.6	-1.6	-0.8
Pulse rate, automated reading	2.1	6.8	20.1	2.6	2.4	0.4	3.2	-4.5	1.6	1.4
Alcohol intake frequency.	0.9	2.0	5.2	-0.0	0.9	1.5	0.9	-0.5	2.1	-2.3
Comparative height size at age 10	0.7	3.7	13.3	0.5	3.6	-0.5	2.2	-2.2	0.6	1.2
Number of full sisters	0.6	0.7	3.2	-0.7	-1.8	0.8	-0.8	-0.2	0.4	-0.3
Suffer from ‘nerves’	1.5	2.4	6.4	0.9	0.4	-0.2	2.5	-2.0	2.3	-0.1
Overall health rating	1.1	2.3	14.1	3.8	-0.1	-0.9	0.9	-0.0	-0.2	0.5
Chest pain or discomfort	0.3	0.4	1.0	0.2	-0.3	0.8	0.4	-0.6	1.0	-0.6
Had major operations	0.4	0.5	1.5	0.5	-1.0	-1.2	-0.5	0.6	-0.4	-0.3
Age at last live birth	0.6	0.8	4.7	-0.2	0.2	-0.5	0.6	0.5	2.2	-0.4
Family relationship satisfaction	0.6	0.8	2.5	0.2	-0.5	-1.0	0.5	-1.0	-0.7	1.6
Leg pain on walking	1.4	1.7	6.2	2.5	-0.2	1.5	1.4	-0.8	0.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.6	2.1	1.1	1.3	0.6	-0.4	0.4	-1.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.8	-0.4	-1.0	0.9	-2.2	2.0	-0.9	-0.6
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	9.7	-1.9	0.5	-3.1	-0.4	-0.6	0.6	1.7
Medication: Aspirin	0.8	1.1	4.1	1.6	-0.3	-2.0	0.1	0.2	0.5	-0.6
Supplements: Vitamin C	0.3	0.3	0.8	0.6	-0.7	0.1	-0.7	0.2	0.1	-0.9
Knee pain experienced in last month	0.7	1.1	2.6	1.6	-1.1	-0.8	0.3	0.9	0.4	1.4
Hypertension (Self-reported)	0.3	0.8	2.1	-0.1	0.6	-0.4	-0.8	1.5	-0.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-1.0	-0.6	-0.9	-0.2	-0.0	0.6	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.9	0.7	-0.8	-0.3	0.9	-0.2	-0.0	0.1
Illnesses of siblings: Diabetes	2.5	3.1	6.7	-0.2	-2.4	-0.8	-2.6	2.1	-2.0	0.3
Smoking status: Previous	1.9	2.9	7.3	-0.3	-2.7	-1.3	-1.4	2.3	0.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	8.5	-1.1	2.9	0.2	0.3	-1.6	0.1	-0.7
Whole body fat-free mass	0.5	2.7	13.6	0.8	0.3	3.7	1.3	0.4	-1.6	-0.0
Leg fat-free mass (right)	0.6	3.2	15.1	0.5	0.0	3.9	0.7	0.7	-2.4	0.6
Arm fat percentage (left)	1.5	6.1	16.6	2.1	-1.3	4.1	-0.9	1.7	-4.0	0.3
Average weekly red wine intake	1.8	2.6	7.6	1.6	2.8	0.8	0.6	-2.4	-0.9	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.7	-0.1	-0.7	-0.5	0.6	-0.5	0.1
Mood swings	1.2	2.2	6.6	1.3	-0.5	-1.3	1.9	-0.6	2.6	-1.0
Loneliness, isolation	1.3	1.8	5.2	0.1	-0.7	0.4	1.8	-1.4	2.3	-1.3
Long-standing illness, disability or infirmity	1.2	1.9	8.0	2.8	-1.5	-0.7	1.2	0.5	-0.5	0.5
Ever had bowel cancer screening	0.7	0.9	4.0	2.0	-0.8	-0.6	0.2	0.8	-0.5	-0.1
Diabetes diagnosed by doctor	1.4	2.4	6.9	0.1	-0.5	1.6	-2.6	2.0	-1.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	0.6	0.2	-0.3	1.2	-0.2	0.2	0.6
Friendships satisfaction	0.4	0.5	1.7	0.5	-1.3	-1.1	0.2	-0.3	0.6	0.4
Qualifications: nursing, teaching	1.5	2.3	10.8	-0.9	-0.5	-0.3	0.4	-1.0	-1.8	3.3
Commuting to job workplace: Walk	0.6	0.6	1.6	-0.8	0.7	-0.9	-0.3	-1.2	0.3	0.7
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	0.0	-0.3	-0.4	-0.3	-0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.3	1.1	-0.7	-0.1	1.4	-0.2	1.5	-0.0
Medication for cholesterol	0.2	0.3	1.1	0.1	0.8	-0.3	0.6	-1.0	-0.4	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.4	2.1	1.4	-0.5	1.6	-0.4	0.2	-1.9
Back pain experienced in last month	0.8	1.1	2.8	1.2	-1.0	0.1	0.2	1.1	-1.7	-1.0
Mineral and other dietary supplements	1.5	2.0	7.2	-0.2	-0.6	-1.7	-1.1	2.7	1.6	-0.3
Breast cancer (self-reported)	0.7	0.8	2.4	0.7	-1.4	-0.8	0.4	0.4	1.6	-0.2
Asthma (self-reported)	1.1	2.2	5.6	0.8	-1.1	-0.3	-2.4	1.7	-1.9	1.0
Osteoporosis (self-reported)	0.6	0.7	3.1	0.3	-1.0	-1.8	-0.4	0.0	-0.3	0.7
Osteoarthritis (self-reported)	0.9	1.1	4.5	-0.3	-0.5	1.6	-0.5	0.5	-2.1	-0.1
Medication: Aspirin	0.7	0.9	3.7	1.5	-0.3	-1.9	0.3	0.0	0.4	-0.1
Medication: Gliclazide	1.7	1.9	4.2	1.3	-0.5	0.2	-1.9	1.7	-2.0	0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	3.7	-0.5	1.9	0.6	0.3	-1.2	-0.9	-0.4
Smoking status: Current	1.1	1.7	6.4	-1.0	-0.3	-0.1	-2.0	2.5	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.6	-0.1	0.3	-0.2	1.3	-0.2	0.4	-0.5
Whole body water mass	0.5	2.7	13.5	0.9	0.3	3.7	1.2	0.3	-1.6	0.0
Leg predicted mass (right)	0.6	3.3	15.8	0.5	0.0	4.0	0.7	0.7	-2.4	0.6
Arm fat mass (left)	1.4	5.6	18.3	2.0	-1.0	4.3	-0.3	1.5	-3.7	0.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.5	0.3	-1.0	-0.3	-1.9	1.7	-1.8	0.4
Average weekly champagne plus white wine intake	0.3	0.5	1.3	-0.9	-0.0	-1.2	0.2	0.9	0.4	-0.3
Miserableness	0.4	0.7	1.9	1.4	0.5	-0.6	1.0	-0.7	0.1	-1.1
Guilty feelings	0.2	0.3	0.6	-0.3	-0.6	-0.0	-0.7	0.8	0.3	-0.3
Wears glasses or contact lenses	2.1	2.4	6.6	2.4	-0.2	0.7	-0.5	-0.6	-2.6	1.9
Ever taken oral contraceptive pill	0.6	0.7	4.1	-0.3	-0.5	0.7	0.2	0.1	0.1	-2.0
Hearing aid user	1.0	1.1	4.1	2.0	1.1	0.2	0.3	-1.2	-0.4	-0.8
Mother’s age at death	1.1	1.3	2.8	0.5	-1.7	0.5	-0.8	-0.7	-1.6	1.5
Financial situation satisfaction	3.2	4.0	8.8	3.0	1.4	-1.0	1.9	-2.8	1.0	1.8
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.4	1.5	2.1	0.8	-0.7	-1.9	0.3	-0.3
Commuting to job workplace: Public transport	0.6	0.8	3.1	0.3	-0.3	-0.1	1.4	-0.2	0.2	1.8
Eye problems/disorders: Glaucoma	1.8	2.1	4.9	-1.9	-0.8	-0.8	-2.2	1.9	0.5	-1.1
Medication: Blood pressure	0.1	0.2	0.3	0.5	-0.5	-0.5	0.1	0.5	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.1	4.9	2.2	-1.0	0.8	-0.0	-0.4	-0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.2	0.4	-1.1	0.4	0.7	-2.0	-1.1	0.8
High cholesterol (Self-reported)	0.5	0.9	1.8	-0.7	-0.7	-0.1	-0.6	1.2	1.3	-1.3
Medication: Bendroflumethiazide	0.7	1.1	2.3	-0.8	-1.0	-1.5	0.5	1.1	0.4	1.4
Medication: Paracetamol	0.8	1.3	4.7	0.5	-1.8	2.2	0.1	-0.0	-0.8	-0.3
Medication: Lisinopril	0.5	0.6	1.9	0.4	0.2	-0.4	-1.4	-0.2	0.8	1.2
Medication: Atorvastatin	0.6	0.7	2.3	-0.6	-0.7	-0.2	-1.5	1.2	0.4	-0.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.4	0.8	-1.0	-0.2	-0.9	0.1	1.1
Alcohol drinker status: Never	1.1	1.3	3.1	-1.4	0.3	1.8	0.0	-1.1	-0.3	1.6
Ever smoked	2.8	5.0	13.6	-0.9	-3.2	-1.4	-1.7	3.7	0.4	-2.3
Basal metabolic rate	0.6	3.2	16.2	0.9	0.3	4.0	1.0	0.6	-1.9	-0.0
Leg fat percentage (left)	1.4	5.1	12.6	2.0	-1.3	3.5	-0.7	2.0	-3.6	-0.5
Arm fat-free mass (left)	0.5	2.5	12.0	1.2	0.1	3.5	1.2	0.7	-1.4	-0.0
Number of operations (self-reported)	0.4	0.5	2.6	0.7	-1.6	0.0	-0.2	0.3	-0.7	0.3
Average weekly beer plus cider intake	0.6	0.9	4.3	-0.5	-2.1	0.9	0.8	0.3	-0.4	0.5
Irritability	0.6	1.0	2.6	0.6	-1.3	-1.2	-0.0	0.5	1.6	-0.5
Risk taking	1.0	1.5	4.0	-1.6	-1.5	1.2	-0.2	2.0	-0.1	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	1.0	-0.1	0.9	0.9	-0.9	-0.1	0.2
Fractured/broken bones in last 5 years	1.0	1.3	3.3	-0.3	-1.5	0.5	-1.8	1.3	-0.4	-1.3
Age started oral contraceptive pill	1.9	2.4	8.1	0.2	0.4	-2.9	1.3	-1.3	2.0	1.0
Diastolic blood pressure, automated reading	0.2	0.5	2.0	-0.3	-0.5	0.1	1.4	0.9	-0.7	-0.1
Ever depressed for a whole week	0.7	0.9	2.1	-0.1	-1.4	-0.4	-1.0	0.9	0.4	-1.4
Unable to work because of sickness or disability	1.6	2.1	4.6	1.7	2.1	2.1	0.7	-1.2	0.2	-0.7
Commuting to job workplace: Cycle	0.4	0.5	2.0	0.1	0.6	-1.4	-0.6	0.6	0.6	-0.6
Myopia	0.6	0.9	2.5	0.4	-0.4	-1.6	1.0	0.1	1.0	1.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	0.3	-0.5	1.1	0.2	-1.3	-0.7	1.5
Cholesterol lowering medication	0.5	0.7	2.0	0.6	-1.4	-0.0	0.1	0.6	1.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	0.8	0.3	-1.1	-1.6	0.3	1.5	-0.5
Pain experienced in last month	1.6	2.6	6.7	-2.6	2.5	1.3	-0.5	-1.7	-0.4	0.6
Supplements: Calcium	1.7	1.8	4.8	1.2	-0.5	1.2	1.6	-2.2	1.2	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	-0.4	-1.0	1.0	-0.7	1.4	-0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.8	0.1	0.0	-1.3	-0.5	-0.2	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	5.6	-1.2	-1.3	1.0	-1.1	1.0	-2.4	1.4
Heart disease (siblings)	1.0	1.3	2.9	0.0	-1.5	-0.9	-1.2	1.7	-1.2	0.0
Alcohol drinker status: Previous	1.1	1.3	5.2	0.1	-0.9	1.1	-0.4	-0.1	1.3	-2.3
Pack years of smoking	0.8	1.1	3.6	-0.1	-1.9	0.3	0.8	0.1	1.3	-1.4
Impedance of whole body	0.6	2.8	9.2	-0.8	2.0	-3.0	-0.1	-1.9	1.4	0.1
Leg fat mass (left)	1.5	6.0	19.1	1.7	-1.2	4.4	-0.2	1.9	-3.8	-0.4
Arm predicted mass (left)	0.5	2.3	11.6	1.2	-0.1	3.4	1.2	0.6	-1.2	-0.1