Hub : Genes

ARRB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2940 0.0950 2.0e-03 0.078 NA 0.187 NA 0.142 1.6e-03 NA 1.0e-06 NA 2.3e-05
2 GTEx Heart Left Ventricle 0.2072 0.0549 3.9e-05 0.141 NA 0.121 NA 0.135 5.8e-08 NA 5.6e-07 NA 1.2e-07
3 GTEx Lung 0.1437 0.0428 4.8e-05 0.098 NA 0.106 NA 0.087 6.4e-08 NA 1.6e-08 NA 3.6e-07
4 GTEx Whole Blood 0.1050 0.0330 2.0e-04 0.123 NA 0.092 NA 0.116 1.9e-11 NA 8.1e-09 NA 8.2e-11
5 METSIM Adipose 0.0955 0.0256 6.8e-07 0.004 0.043 0.036 0.022 0.030 6.9e-02 4.1e-07 3.5e-06 2.5e-04 2.4e-05
6 NTR Blood 0.0375 0.0120 2.9e-05 0.029 0.013 0.018 0.023 0.027 1.1e-09 2.6e-05 1.1e-06 3.5e-08 2.6e-09
7 YFS Blood 0.0581 0.0144 1.0e-09 0.046 0.038 0.048 0.048 0.044 1.1e-14 1.5e-12 1.5e-15 2.5e-15 2.2e-14
8 TCGA Breast Invasive Carcinoma 0.0135 0.0073 2.5e-03 0.016 0.005 0.005 NA 0.009 2.5e-04 2.3e-02 3.4e-02 NA 4.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.2 0.3 1.2 -1.1 -0.0 -0.6 -0.4 0.4 -0.1 -0.8 0.0
Bipolar Disorder or Schizophrenia 0.3 0.8 2.1 -0.9 0.2 -1.2 -0.5 -1.4 -0.4 -1.2 0.2
Depressed Affect (Nagel 2018) 0.8 1.6 3.9 -0.2 -0.7 1.5 1.5 2.0 1.3 1.6 0.0
Depression (Nagel 2018) 3.1 4.6 8.0 1.0 -1.9 2.2 2.3 2.8 2.1 2.5 1.8
Intelligence (Savage-Jansen 2018) 0.3 1.0 3.5 -1.1 0.4 -1.9 -0.6 -0.9 -0.7 -1.2 -0.0
Neuroticism (Nagel 2018) 0.3 0.8 3.7 -0.5 -0.1 0.2 0.7 1.9 0.5 1.1 -0.4
Schizophrenia (2018) 0.4 0.9 4.7 -0.3 0.2 -1.1 -0.4 -2.2 -0.4 -0.9 0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 3.9 0.0 0.0 0.0 0.0 -2.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.2 0.4 1.9 0.0 0.1 -0.1 0.2 1.4 0.1 1.0 -0.2
Alzheimer’s Disease (in mother) 1.5 1.8 3.1 -0.3 1.3 -0.9 -1.7 1.2 -1.7 -1.8 -1.2
Alzheimer’s Disease (in father) 0.4 0.4 2.0 -0.8 0.5 0.1 0.1 1.4 -0.2 -0.6 -0.4
Alzheimer’s Disease (including proxy) 1.0 1.5 2.9 -0.7 1.4 -0.3 -1.1 1.6 -1.2 -1.7 -1.1
Crohns Disease (2017) 1.4 3.0 7.3 1.1 -1.6 1.3 2.1 2.7 2.0 1.5 0.8
Irritable Bowel Disease (IBD) 4.3 10.1 13.2 2.7 -3.2 3.5 3.6 2.6 3.6 3.3 2.7
Ulcerative Colitis (UC) 5.7 10.8 17.8 3.1 -3.4 4.2 3.4 1.6 3.4 3.2 3.3
Major Depression (MDD) 0.6 0.8 2.4 -1.5 0.9 -0.5 -0.6 0.6 -0.8 -0.0 -1.2
Reaction Time 0.9 1.7 2.6 -1.2 1.4 -1.0 -1.6 1.5 -1.4 -1.3 -1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 -0.1 -0.9 -0.2 0.6 -0.8 0.7 0.1 1.2
Breast Cancer 0.1 0.2 0.6 0.1 0.7 -0.3 -0.8 0.2 -0.6 -0.1 -0.4
Ovarian Cancer 1.0 1.3 2.3 -0.9 1.3 -1.0 -1.5 -0.1 -1.4 -1.3 -1.1
Prostate Cancer 0.1 0.2 0.9 1.0 -0.2 -0.1 -0.2 0.0 -0.1 0.0 0.7
Age at First Birth 0.8 1.2 2.1 -1.4 1.1 -0.7 -0.9 -0.6 -1.1 -1.2 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 0.9 -0.3 -0.9 0.2 0.7 0.4 0.8 1.0 0.9
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 2.0 3.3 7.0 1.7 -1.5 1.7 2.0 2.6 1.9 1.2 1.4
Mean Putamen Volume 0.4 0.4 0.8 -0.7 0.6 -0.4 -0.6 0.1 -0.4 -0.9 -0.9
Fasting Glucose 0.9 1.1 3.4 -0.7 0.9 0.3 -1.1 0.4 -1.3 -0.8 -1.8
HbA1C 0.5 0.6 2.6 -0.0 -0.5 -0.1 1.0 0.5 0.6 1.6 -0.1
HDL Cholesterol 0.9 1.5 7.0 1.5 0.1 1.2 0.3 2.6 0.0 1.0 -0.2
LDL Cholesterol 2.8 4.4 7.5 1.6 -2.1 2.1 2.7 0.8 2.6 2.4 1.7
Lupus 2.1 3.2 8.1 0.8 -1.9 0.9 2.1 -0.4 2.0 2.8 2.0
Neuroticism (2016) 2.3 3.3 4.7 0.9 -2.1 2.1 1.9 1.0 2.1 2.2 1.6
Primary Biliary Cirrhosis 0.3 0.4 1.0 1.0 -0.8 0.5 0.6 0.2 0.3 0.9 0.4
Rheumatoid Arthritis 1.4 1.9 5.7 1.1 -1.3 0.3 1.2 -0.8 1.3 2.4 1.5
Schizophrenia (2014) 0.6 1.3 5.5 -0.7 0.6 -1.2 -0.5 -2.3 -0.7 -1.2 -0.1
Triglycerides 0.4 0.6 2.0 -1.2 -0.4 -0.6 0.3 -1.4 0.5 -0.1 0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 -0.6 0.7 -0.5 -0.9 0.4 -0.7 0.0 0.0
Ulcerative Colitis 5.5 7.9 11.4 2.7 -2.9 3.4 2.9 1.3 2.9 2.7 3.2
Blood Eosinophil Count 9.5 73.1 102.0 -5.8 8.4 -9.8 -9.8 -4.6 -10.1 -9.9 -8.3
Blood Platelet Count 1.1 12.2 50.1 1.9 -2.4 4.4 2.7 7.1 2.5 1.5 1.9
Blood Red Count 0.0 0.4 2.8 0.2 0.1 -0.2 -0.3 1.7 -0.1 -0.0 0.6
Blood White Count 5.7 41.9 68.7 6.2 -6.7 4.8 6.6 8.3 6.4 6.7 5.5
Heel T-Score 0.6 4.7 5.9 2.4 -2.3 1.9 2.4 1.2 2.4 2.1 2.4
BMI 1.4 8.1 19.5 2.3 -2.9 2.3 2.8 4.4 2.6 1.9 2.9
Height 0.1 1.5 3.6 0.1 -0.9 1.9 1.1 1.0 1.4 1.5 1.1
Waist Hip Ratio (WHR) 0.1 0.6 2.7 1.6 -0.8 0.8 0.3 0.4 0.5 -0.3 0.3
Systolic Blood Pressure 0.7 3.7 6.4 1.7 -2.3 1.3 2.5 0.3 2.4 2.2 1.7
Smoking Status 0.2 0.6 1.8 0.3 -1.3 0.1 1.0 0.2 1.0 0.6 0.8
Allergy or Eczema 0.1 0.2 0.5 0.5 -0.5 -0.4 0.2 0.5 -0.2 0.1 0.7
Cardiovascular Disease 0.1 0.4 1.3 0.4 -0.1 -1.1 -0.6 -1.0 -0.4 -0.5 -0.2
Hypothyroidism (self reported) 0.4 1.0 3.1 0.9 -0.6 0.4 0.8 1.4 0.8 1.8 0.5
Respiratory disease 0.7 1.5 2.7 1.6 -1.2 0.9 1.1 1.4 1.1 1.2 1.1
Type 2 Diabetes (T2D) (2018) 2.7 5.0 8.0 -1.7 2.4 -2.3 -2.8 0.5 -2.5 -2.7 -2.1
Lung FEV1/FVC ratio 0.2 0.9 2.9 1.7 -1.1 0.3 0.6 -0.2 0.4 -1.5 0.7
Lung FVC 0.6 2.9 7.9 1.2 -1.1 1.4 1.7 1.8 1.7 2.8 1.2
Neuroticism 0.8 1.9 6.8 -0.0 -0.8 0.2 1.2 2.6 1.2 2.1 0.3
Chronotype (morning person) 0.5 1.2 2.2 -0.6 1.2 -0.4 -1.5 -0.7 -1.4 -1.1 -1.4
Hair Pigment 0.0 0.6 1.2 0.1 -0.5 0.4 1.1 0.1 1.1 0.9 0.8
Tanning 0.0 0.2 0.6 0.0 0.3 -0.3 -0.7 0.1 -0.7 -0.2 -0.4
Hand grip strength (left) 0.6 1.7 3.9 1.3 -1.1 1.4 1.4 -0.1 1.4 2.0 1.0
Number of treatments/medications taken 0.8 1.5 2.6 1.6 -1.6 0.9 1.2 1.1 1.2 0.8 1.2
Average weekly spirits intake 0.4 0.5 1.9 -0.7 0.6 -0.6 -0.5 1.4 -0.6 -0.1 -0.7
Sensitivity / hurt feelings 0.4 0.6 3.4 -0.1 -0.1 -0.7 0.0 1.9 0.0 1.1 0.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.7 0.2 -0.8 0.6 0.8 1.9 0.7 1.2 0.8
Hearing difficulty/problems: Yes 3.0 4.6 8.1 2.8 -2.0 1.9 1.9 2.5 1.8 1.8 2.1
Relative age of first facial hair 0.3 0.5 1.7 1.3 -0.8 -0.0 0.2 -1.1 0.1 0.2 0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.6 -0.8 0.1 -0.2 0.1 0.1 -0.0 0.7 -0.1
Ever used hormone-replacement therapy (HRT) 2.9 3.7 5.2 1.9 -2.0 1.5 2.1 1.5 2.2 2.3 1.8
Ever had hysterectomy (womb removed) 0.8 0.9 2.7 0.6 -0.2 1.6 0.5 1.6 0.3 1.0 0.4
Systolic blood pressure, automated reading 2.9 8.4 13.9 2.7 -3.0 1.9 3.4 1.8 3.2 3.7 2.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.7 1.2 -1.1 1.1 0.5 0.7 0.8 0.4 1.3
Angina 0.1 0.1 0.5 0.3 0.2 -0.7 -0.1 0.4 -0.0 -0.3 -0.3
Medication for hormone replacement therapy 0.2 0.2 0.7 0.8 -0.6 -0.1 0.3 0.0 0.1 -0.6 0.5
Vitamin and mineral supplements 0.9 1.2 2.3 -1.2 0.8 -1.2 -0.9 -0.6 -0.9 -1.5 -1.2
Supplements: Zinc 0.3 0.3 0.8 0.3 -0.6 0.9 0.5 0.1 0.5 -0.5 0.3
Medication: Co-codamol 0.3 0.4 2.0 -0.8 0.2 -0.4 -0.0 1.4 -0.2 0.2 -0.3
Medication: Metformin 1.8 2.6 5.3 -1.6 1.6 -1.3 -1.9 0.8 -1.7 -2.3 -1.1
Diabetes (father) 1.6 2.0 3.1 -0.8 1.6 -1.5 -1.6 -1.0 -1.6 -1.8 -1.3
Diabetes (mother) 3.0 3.9 6.2 -2.2 1.7 -2.5 -1.8 -2.1 -1.6 -2.5 -1.1
Severe depression (siblings) 1.7 1.9 2.7 -1.5 1.6 -1.1 -1.4 0.4 -1.6 -1.2 -1.6
Pack years adult smoking proportion 0.3 0.5 3.0 0.3 -0.3 -0.5 0.1 1.7 0.2 0.8 -0.1
Impedance of leg (right) 0.4 1.9 4.7 -0.5 1.3 -1.1 -1.6 -2.2 -1.5 -0.8 -1.4
Leg fat-free mass (left) 0.5 2.7 9.8 1.0 -1.3 1.2 1.4 3.1 1.5 1.0 1.6
Trunk fat percentage 0.4 1.7 7.0 0.2 -1.0 0.6 1.3 2.6 1.3 0.9 1.1
Hand grip strength (right) 1.1 2.9 4.5 1.7 -1.5 2.1 1.9 0.8 1.9 1.9 1.3
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.5 0.2 0.0 -0.1 0.4 0.1 0.5 0.2
Current tobacco smoking 0.2 0.4 3.0 -0.2 -0.2 -0.2 0.0 1.7 -0.2 0.0 -0.1
Average weekly fortified wine intake 0.5 0.6 2.5 0.5 -0.3 1.0 0.6 1.6 0.4 -0.1 0.3
Maternal smoking around birth 1.1 1.6 2.9 1.7 -1.3 0.6 1.1 1.2 1.2 1.4 1.3
Fed-up feelings 0.7 1.2 2.5 -0.2 -0.8 1.1 1.3 1.6 1.1 1.5 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.6 -0.5 -1.0 0.6 1.1 1.0 1.1 1.2 0.9
Relative age voice broke 0.3 0.5 1.4 1.2 -0.8 -0.5 0.5 -0.3 0.4 0.0 0.9
Taking other prescription medications 0.1 0.1 0.2 0.3 -0.2 -0.4 -0.3 -0.3 -0.2 0.5 0.0
Age when periods started (menarche) 1.5 3.7 5.3 1.9 -2.3 1.8 2.1 -0.1 2.1 2.3 1.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.2 -0.8 1.1 -0.6 -0.8 0.7 -0.6 -0.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 3.5 1.7 -1.9 1.6 1.8 0.3 1.8 1.2 1.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 1.1 1.0 -0.0 0.4 -0.1 0.3 -0.2 -0.8 0.2
Qualifications: CSEs or equivalent 0.9 1.2 5.7 1.8 -0.3 0.3 0.1 2.4 -0.2 -0.2 0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -0.3 0.5 -0.6 -0.5 1.0 -0.4 -0.5 -0.7
High blood pressure 0.2 0.5 1.6 0.7 -0.7 -0.7 -0.2 -1.3 0.2 0.0 1.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.5 0.6 -0.6 0.7 0.3 1.6 0.2 0.6 0.6
Multivitamins +/- minerals 0.9 1.1 2.3 0.8 -0.7 1.5 0.8 1.0 0.9 1.5 1.1
Stomach or abdominal pain in last month 0.4 0.5 2.9 -0.2 0.6 -0.3 0.0 1.7 -0.2 0.0 -0.7
Supplements: Glucosamine 0.3 0.4 1.0 0.5 -0.2 0.8 0.8 1.0 0.6 0.3 -0.1
Diverticular disease/diverticulitis (self-reported) 1.7 2.1 3.1 1.1 -1.6 1.4 1.6 0.2 1.7 1.4 1.8
Medication: Atenolol 0.5 0.6 1.5 1.2 -0.8 0.7 0.5 0.2 0.9 0.6 1.0
Medication: Levothyroxine sodium 0.5 0.8 1.6 0.5 -0.8 -0.3 1.0 1.1 1.1 1.3 0.8
Sitting height 0.7 5.0 8.0 2.0 -2.0 2.6 2.3 1.3 2.6 2.8 2.0
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.0 0.6 -0.2 -0.7 -0.3 -0.7 -0.5 -0.8
High blood pressure (mother) 3.0 4.2 6.0 -2.0 2.3 -2.5 -2.0 -1.7 -2.2 -1.6 -2.1
Body mass index (BMI) 1.1 4.6 13.0 1.2 -2.1 1.4 2.1 3.6 2.0 1.4 2.4
Impedance of leg (left) 0.3 1.6 4.8 -0.6 1.2 -0.8 -1.4 -2.2 -1.3 -0.8 -1.4
Leg predicted mass (left) 0.5 2.8 9.7 1.0 -1.3 1.3 1.5 3.1 1.6 1.1 1.6
Trunk fat mass 0.7 2.9 9.8 0.5 -1.4 1.0 1.6 3.1 1.7 1.3 1.6
Waist circumference 0.8 2.9 8.3 1.2 -1.7 1.2 1.6 2.9 1.7 1.0 1.8
Number of incorrect matches in round 1.3 2.2 4.0 1.4 -1.2 2.0 1.3 -0.9 1.2 2.0 1.5
Past tobacco smoking 0.9 1.6 5.6 -0.8 1.3 -0.3 -1.1 2.4 -1.3 -1.1 -1.0
Alcohol usually taken with meals 0.3 0.5 1.6 0.7 -0.7 -0.1 0.8 0.2 0.6 1.2 0.3
Nervous feelings 0.4 0.8 1.6 -1.0 1.3 -0.7 -1.1 0.4 -1.1 -0.1 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.7 0.3 -1.3 0.5 1.1 1.1 1.2 1.1 0.9
Hearing difficulty/problems with background noise 5.0 8.0 10.4 3.0 -2.5 2.9 3.1 2.7 3.0 3.2 2.1
Hair/balding pattern: Pattern 2 2.4 3.1 4.6 -1.9 2.0 -1.6 -1.8 -0.4 -1.8 -1.8 -2.1
Had menopause 0.0 0.1 0.3 -0.1 -0.0 0.2 0.1 0.1 0.2 0.2 0.6
Had other major operations 0.6 0.8 1.9 0.5 -1.0 0.6 1.1 1.0 0.7 1.4 0.4
Forced vital capacity (FVC) 0.2 0.9 3.5 0.8 -0.6 0.6 1.2 -0.0 1.1 1.9 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 4.2 1.5 -2.0 1.8 2.1 0.1 1.9 1.3 2.0
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.7 -0.8 0.2 0.4 0.6 1.3 0.5 0.4 -0.7
Qualifications: None of the above 0.2 0.4 2.1 -0.9 0.2 -0.1 -0.2 -1.4 -0.1 -0.4 -0.4
Financial difficulties in last 2 years 1.8 2.4 4.6 1.5 -1.5 2.1 1.1 1.1 1.4 1.5 1.9
Mouth/teeth dental problems 2.2 3.4 5.7 -0.6 1.6 -1.7 -1.9 -2.4 -2.0 -2.1 -1.9
Heart attack 0.2 0.3 1.3 0.0 -0.3 -0.7 -0.1 -0.5 0.3 -1.1 0.0
Allergy 0.3 0.6 2.6 -0.9 0.6 -0.5 -0.3 -1.6 -0.2 -0.2 -0.7
Pain all over the body in last month 0.4 0.4 1.2 -1.1 0.3 -0.7 -0.3 1.0 -0.1 -0.7 0.0
Diabetes (self-reported) 1.5 2.3 4.4 -1.3 1.4 -1.5 -1.9 0.5 -1.6 -2.1 -1.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.5 -0.3 1.2 -0.3 -1.6 -0.7 -1.5 -1.2 -1.3
Medication: Ramipril 2.7 3.5 8.3 -0.8 1.4 -2.2 -2.4 0.5 -2.1 -2.9 -1.3
Medication: Simvastatin 0.1 0.2 0.4 -0.2 0.1 -0.5 -0.6 -0.1 -0.4 -0.6 -0.5
Fluid intelligence score 1.0 2.0 4.0 1.5 -1.9 0.9 1.5 0.3 1.6 0.7 2.0
Illnesses of siblings 0.7 1.0 2.4 -1.6 1.2 -0.4 -0.8 -0.4 -1.0 -0.2 -1.4
Neuroticism score 0.7 1.4 5.2 -0.1 -0.5 -0.2 1.0 2.3 0.8 2.0 0.0
Weight 0.9 4.2 11.5 0.9 -1.8 1.6 2.0 3.4 2.1 1.5 2.2
Impedance of arm (right) 1.2 5.5 8.7 -2.4 2.4 -2.0 -2.2 -2.6 -2.2 -1.7 -3.0
Arm fat percentage (right) 0.4 1.8 7.1 -0.0 -1.0 0.5 1.3 2.7 1.3 1.0 1.2
Trunk fat-free mass 0.6 3.7 7.7 1.3 -1.7 1.9 1.8 2.8 1.9 1.6 2.1
Hip circumference 0.4 1.8 10.1 0.1 -0.8 0.4 1.0 3.2 1.0 0.7 1.1
Time employed in main current job 0.2 0.2 1.3 -0.4 0.3 -0.1 0.1 -0.1 0.1 1.1 -0.5
Alcohol intake versus 10 years previously 0.1 0.1 0.8 0.1 0.1 0.0 0.2 0.9 -0.3 -0.4 -0.2
Father’s age at death 0.3 0.4 1.3 -0.6 0.4 1.0 0.3 1.1 0.1 -0.1 -0.2
Worrier / anxious feelings 0.6 1.0 4.1 -0.6 0.1 -0.3 0.4 1.8 0.2 2.0 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.7 -1.9 0.6 -1.7 -0.7 0.3 -0.8 -0.5 -0.8
Falls in the last year 0.9 1.3 3.0 -1.7 1.5 -0.9 -1.1 0.3 -1.0 -0.6 -1.3
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 0.8 -0.2 0.9 0.4 0.9 0.3 0.7 0.7
Number of live births 0.2 0.3 0.7 0.3 -0.3 0.4 0.7 0.7 0.4 0.8 0.5
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.5 1.1 -0.8 0.3 1.2 0.1 1.1 1.6 0.6
Pulse rate 0.4 0.6 1.5 0.4 -0.9 0.9 0.2 1.1 0.3 0.1 1.2
Happiness 2.8 3.4 6.1 -2.3 1.9 -2.1 -1.4 -1.3 -1.6 -1.4 -2.5
Noisy workplace 0.7 0.9 1.8 0.7 -0.9 1.3 1.0 -0.3 1.0 0.7 1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.3 -1.1 0.9 -0.5 -0.9 -0.8 -1.0 -0.4 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.3 0.0 0.2 -0.5 0.1 -1.1 -0.3 0.0 -0.1
Mouth/teeth dental problems: Dentures 2.6 4.3 8.0 0.9 -1.4 2.6 1.8 2.6 1.9 2.8 1.7
Asthma 0.3 0.6 3.0 1.7 -0.8 -0.1 0.2 0.3 0.3 0.5 0.9
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 4.9 1.3 -1.9 1.4 2.2 -0.0 1.9 1.9 1.9
Medication: Cholesterol lowering 0.2 0.3 1.1 0.6 -0.4 -0.8 -0.1 0.2 -0.1 -1.1 0.1
Depression (self-reported) 2.4 2.9 4.8 -1.9 2.2 -0.8 -1.9 0.1 -1.9 -1.7 -2.0
Medication: Lansoprazole 0.3 0.4 0.9 0.2 0.6 -0.6 -1.0 -0.1 -0.6 -0.6 -0.7
Prospective memory result 2.1 2.6 5.8 -1.6 1.4 -1.3 -1.4 -1.1 -1.7 -2.4 -1.7
Lung cancer (father) 1.2 1.5 4.7 1.6 -1.5 -0.1 0.9 -2.2 0.8 0.6 0.6
Illnesses of mother 3.6 4.4 8.2 1.4 -2.0 2.9 2.3 1.6 2.2 2.5 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.8 0.7 -0.3 -0.0 0.5 -0.2 0.4 0.9 0.0
Pulse wave Arterial Stiffness index 0.4 0.4 1.1 0.7 -0.7 0.0 0.2 -1.1 0.4 -0.6 0.9
Impedance of arm (left) 1.5 7.0 10.2 -2.5 2.6 -2.8 -2.5 -2.8 -2.6 -2.0 -3.2
Arm fat mass (right) 0.7 3.1 10.9 0.5 -1.5 1.0 1.7 3.3 1.7 1.1 1.7
Trunk predicted mass 0.6 3.3 7.6 1.2 -1.5 1.8 1.6 2.8 1.8 1.5 2.0
Standing height 0.0 0.1 0.3 -0.5 0.4 0.5 -0.1 0.1 0.2 0.2 -0.2
Length of working week for main job 3.6 4.0 6.1 1.5 -2.3 1.6 2.2 0.7 2.5 2.4 2.2
Exposure to tobacco smoke at home 0.2 0.2 0.7 -0.3 0.3 0.2 -0.4 0.9 -0.4 -0.1 -0.4
Breastfed as a baby 0.6 0.8 2.8 1.2 -0.5 1.7 0.6 0.4 0.6 0.6 0.7
Tense / ‘highly strung’ 0.2 0.4 1.9 -0.2 0.3 -0.4 0.0 1.4 -0.1 0.9 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.2 -1.8 1.4 -1.0 -0.8 1.1 -0.8 -0.3 -1.6
Hair/balding pattern: Pattern 4 1.1 2.7 4.5 2.1 -2.1 1.1 1.6 -1.2 1.6 1.0 1.9
Birth weight of first child 0.5 0.9 3.7 -1.9 0.6 -0.9 -0.4 -0.2 -0.3 -1.1 -0.9
Peak expiratory flow (PEF) 1.2 2.8 4.1 2.0 -1.9 0.9 1.7 1.2 1.7 2.0 1.8
Pulse wave reflection index 0.4 0.5 1.5 1.2 -0.6 -0.0 0.6 -0.9 0.5 0.5 0.6
Ever highly irritable/argumentative for 2 days 1.5 1.8 2.6 -1.6 1.4 -1.6 -1.5 0.6 -1.3 -1.2 -1.0
Loud music exposure frequency 0.2 0.2 0.6 0.1 -0.3 0.5 0.3 -0.8 0.1 0.4 0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.6 -1.3 0.6 -0.6 -0.5 -0.1 -0.5 -0.3 -0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.9 0.2 -0.3 -0.1 0.5 0.1 0.8 0.8 1.0
Blood clot in the leg (DVT) 0.1 0.1 0.3 -0.1 -0.3 -0.1 0.6 -0.0 0.4 -0.5 0.3
Medication: Paracetamol 1.9 3.2 4.2 1.8 -1.9 1.5 1.9 1.8 1.7 2.1 1.5
Headache pain in last month 1.7 2.9 4.9 -0.8 1.6 -2.2 -1.6 -1.0 -2.1 -2.1 -1.6
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.0 -0.6 -0.0 1.0 0.8 0.6 0.7 1.4 -0.3
Glaucoma (self-reported) 2.0 2.4 4.5 -1.0 1.8 -1.2 -1.6 -2.1 -1.7 -1.1 -1.5
Gout (self-reported) 0.9 1.2 2.0 0.8 -1.1 1.3 1.4 0.5 1.4 1.1 0.8
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 4.0 1.0 -0.6 0.3 0.8 2.0 0.8 1.6 0.6
Medication: Amlodipine 1.8 2.5 5.7 -2.1 1.1 -1.7 -1.1 -2.4 -1.0 -1.7 -0.9
Medication: Ventolin 100micrograms inhaler 0.7 1.0 3.3 1.0 -0.6 1.0 0.3 1.8 0.5 1.0 0.8
Birth weight 1.3 2.9 7.3 -2.7 2.0 -0.2 -1.3 -0.3 -1.3 -1.5 -2.6
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.7 -0.4 0.0 -0.8 -0.4 -0.5 -0.4 -1.3 -0.1
High blood pressure (siblings) 4.7 6.8 13.7 3.7 -2.8 2.5 2.5 0.0 2.7 1.8 3.2
Forced vital capacity (FVC), Best measure 0.1 0.2 1.0 0.3 0.1 0.1 0.4 -0.6 0.3 1.0 -0.3
Body fat percentage 0.6 2.4 8.2 0.5 -1.3 0.8 1.4 2.9 1.5 1.3 1.4
Leg fat percentage (right) 1.4 4.9 10.6 1.6 -2.1 1.4 2.1 3.2 2.1 2.2 2.5
Arm fat-free mass (right) 1.0 4.9 10.6 1.5 -1.9 2.0 2.0 3.3 2.2 1.9 2.5
Exposure to tobacco smoke outside home 0.9 1.2 2.4 1.6 -1.2 0.3 0.8 0.8 1.0 1.0 1.4
Comparative body size at age 10 0.1 0.2 0.4 -0.6 -0.1 0.7 0.4 -0.0 0.4 0.5 0.5
Number of full brothers 0.1 0.1 0.6 0.5 -0.1 0.6 0.1 0.0 0.1 -0.8 -0.2
Worry too long after embarrassment 0.9 1.5 3.5 0.4 -1.4 0.3 1.5 1.9 1.5 1.0 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 6.3 -0.9 0.3 0.1 0.3 2.5 0.3 0.9 -0.3
Wheeze or whistling in the chest in last year 1.0 1.7 3.0 1.4 -1.7 0.8 1.3 1.4 1.3 0.8 1.6
Number of children fathered 3.2 3.6 5.5 1.9 -2.1 1.2 2.3 0.3 2.3 2.2 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.4 0.5 -0.1 0.2 0.4 1.2 0.3 -0.1 0.1
Age at first live birth 0.2 0.3 1.3 0.5 0.1 0.8 0.3 -1.2 0.2 0.5 -0.1
Pulse wave peak to peak time 0.3 0.4 1.0 -0.6 0.6 0.1 -0.1 1.0 -0.2 0.8 -0.7
Health satisfaction 0.6 0.7 1.5 0.2 -1.2 0.2 1.1 0.1 1.0 1.2 0.8
Shortness of breath walking on level ground 0.2 0.2 0.8 -0.4 -0.3 -0.2 0.4 0.1 0.4 0.9 0.2
Qualifications: College or University degree 0.0 0.1 0.2 0.4 0.3 0.3 -0.4 -0.3 -0.4 0.2 -0.0
Eye problems/disorders: None of the above 0.1 0.1 0.5 -0.2 0.4 -0.0 -0.1 0.4 -0.5 -0.7 -0.1
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 -0.1 -0.1 0.9 0.7 0.8 0.5 0.7 -0.3
Emphysema/chronic bronchitis 0.3 0.4 0.9 -0.7 0.2 -0.4 -0.6 0.7 -0.4 -0.9 0.6
Medication for pain relief, constipation, heartburn 2.1 3.5 5.5 -1.6 2.4 -0.7 -2.0 -1.6 -1.9 -2.3 -1.9
Neck or shoulder pain in last month 2.7 3.8 6.0 2.4 -2.2 1.2 2.3 0.2 2.4 1.8 1.9
Medication: Blood pressure 0.3 0.6 1.7 0.4 -0.2 -1.0 -0.7 -0.8 -0.5 -1.3 0.6
Angina (self-reported) 0.1 0.1 0.5 0.3 0.1 -0.7 -0.2 0.3 -0.0 -0.4 -0.1
Migraine (self-reported) 2.4 3.0 5.4 -1.3 2.3 -1.3 -1.8 -1.8 -1.9 -0.8 -2.1
Medication: Ibuprofen 2.4 2.9 4.7 1.5 -2.0 1.1 2.2 0.3 2.0 1.8 1.9
Medication: Allopurinol 0.0 0.1 0.2 0.3 0.1 0.2 0.1 -0.4 0.2 -0.0 -0.4
Medication: Omeprazole 0.4 0.4 0.9 0.9 -0.8 0.3 0.5 0.4 0.6 0.5 0.8
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.2 0.3 -0.5 -0.4 -0.5 -0.5 -0.1 0.0
Mean time to correctly identify matches 0.3 0.6 1.2 -0.9 0.9 -0.3 -0.9 1.1 -0.7 -0.7 -0.4
Heart disease (mother) 0.5 0.6 2.0 -1.4 0.7 -0.8 -0.4 -0.8 -0.5 -0.3 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.1 7.2 1.5 -1.7 1.2 1.7 1.9 1.8 2.7 1.2
Whole body fat mass 0.9 3.6 11.1 0.8 -1.7 1.2 1.8 3.3 1.9 1.5 1.9
Leg fat mass (right) 1.2 4.8 12.0 1.2 -2.0 1.5 2.1 3.5 2.2 1.9 2.4
Arm predicted mass (right) 1.3 6.5 10.4 2.0 -2.4 2.4 2.4 3.2 2.6 2.2 3.0
Pulse rate, automated reading 1.0 3.4 8.9 1.6 -1.7 2.2 1.4 3.0 1.6 1.2 1.4
Alcohol intake frequency. 0.7 1.7 2.3 -0.9 1.5 -1.0 -1.4 1.5 -1.3 -1.4 -1.5
Comparative height size at age 10 0.2 0.9 3.8 -0.4 0.8 0.3 -0.8 -0.9 -0.8 -1.9 -0.6
Number of full sisters 0.6 0.7 1.2 -1.1 0.9 -0.9 -0.8 -0.0 -0.9 -0.5 -0.9
Suffer from ‘nerves’ 0.2 0.3 1.5 0.5 -0.3 -0.1 0.5 1.2 0.3 0.4 0.1
Overall health rating 0.5 1.0 2.1 0.4 -1.4 0.3 1.4 0.7 1.2 1.0 1.1
Chest pain or discomfort 0.6 0.8 1.5 -0.3 1.1 -1.0 -1.2 0.4 -1.2 -0.5 -1.2
Had major operations 0.3 0.3 1.0 -0.7 0.8 -0.6 -0.2 0.2 -0.2 -0.1 -1.0
Age at last live birth 0.2 0.3 1.9 -0.1 0.5 -0.3 -0.3 -1.4 -0.5 -0.4 -0.2
Family relationship satisfaction 0.3 0.4 2.4 -1.5 0.4 -0.1 0.0 -0.7 0.0 0.0 -0.5
Leg pain on walking 0.1 0.2 0.6 -0.8 0.1 0.0 0.2 0.7 0.3 -0.3 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 6.0 1.4 -1.3 1.3 1.1 2.4 1.0 1.2 1.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.0 -0.6 0.4 -1.2 -1.0 -1.4 -0.8 -1.0 -0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.4 0.0 -0.0 0.3 -0.3 -0.6 -0.2 0.2 0.1
Medication: Aspirin 0.8 1.0 2.6 1.3 -1.6 0.0 0.8 0.3 1.1 0.4 1.4
Supplements: Vitamin C 0.7 0.8 2.4 1.5 -1.2 -0.4 0.8 0.5 0.8 0.7 0.9
Knee pain experienced in last month 1.1 1.6 3.2 0.5 -1.6 0.8 1.8 -0.9 1.7 1.0 1.4
Hypertension (Self-reported) 0.2 0.5 1.8 0.5 -0.5 -0.8 -0.5 -1.4 0.0 -0.2 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.2 0.3 -0.0 -0.2 0.6 -0.1 0.4 0.1
Illnesses of father: Heart disease 0.5 0.7 3.9 -0.4 -0.2 0.5 0.3 2.0 0.3 1.0 0.5
Illnesses of siblings: Diabetes 1.8 2.3 3.7 -1.6 1.4 -1.4 -1.4 -1.4 -1.4 -1.9 -1.4
Smoking status: Previous 0.7 1.1 6.7 0.3 -0.7 0.0 0.6 -2.6 0.8 0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.4 1.2 0.5 0.2 -0.6 0.9 -0.7 -0.4 -0.9
Whole body fat-free mass 0.6 3.5 8.9 1.2 -1.6 1.7 1.7 3.0 1.8 1.4 2.1
Leg fat-free mass (right) 0.5 2.9 9.1 1.0 -1.4 1.5 1.6 3.0 1.6 1.0 1.7
Arm fat percentage (left) 0.5 1.8 9.2 -0.2 -0.9 0.3 1.2 3.0 1.1 0.9 1.0
Average weekly red wine intake 0.4 0.6 2.0 0.9 -0.7 0.8 0.4 1.4 0.4 0.2 0.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 -0.3 -0.8 0.9 0.7 -0.3 0.9 1.2 0.9
Mood swings 0.4 0.7 2.9 -1.7 0.4 -0.1 0.1 0.8 0.2 1.2 -0.8
Loneliness, isolation 0.3 0.5 1.1 -1.0 -0.2 1.0 0.8 0.2 0.7 0.6 0.1
Long-standing illness, disability or infirmity 0.7 1.0 2.0 1.0 -1.1 0.7 1.0 1.2 0.9 1.4 0.6
Ever had bowel cancer screening 1.4 1.6 2.8 1.4 -1.5 0.9 1.7 0.4 1.6 1.1 1.1
Diabetes diagnosed by doctor 0.9 1.5 2.5 -1.0 1.1 -1.2 -1.5 1.1 -1.2 -1.6 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 0.2 -0.3 -0.6 0.3 -0.1 0.1 0.1 -0.0
Friendships satisfaction 0.1 0.1 0.5 -0.6 0.2 0.1 0.1 0.2 0.1 -0.2 -0.7
Qualifications: nursing, teaching 0.3 0.5 1.4 0.8 -0.7 1.0 0.5 0.3 0.5 0.4 1.2
Commuting to job workplace: Walk 1.8 1.9 3.5 -1.6 1.9 0.1 -1.3 -0.1 -1.3 -1.6 -1.8
Eye problems/disorders: Cataract 0.5 0.5 1.6 0.5 -1.3 0.1 0.8 -0.2 1.0 -0.0 0.9
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.7 0.3 -1.4 0.7 1.6 1.3 1.6 1.4 1.3
Medication for cholesterol 0.3 0.4 1.9 0.3 -0.0 0.7 0.6 1.4 0.3 0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.1 1.0 -1.8 0.3 1.2 0.7 1.1 1.1 1.6
Back pain experienced in last month 0.1 0.2 0.7 -0.1 -0.1 0.8 0.7 -0.1 0.5 0.0 0.1
Mineral and other dietary supplements 5.7 7.7 9.4 -2.9 2.6 -3.0 -3.1 -2.5 -3.0 -2.1 -2.9
Breast cancer (self-reported) 0.2 0.2 0.6 0.5 -0.4 0.3 0.5 0.2 0.4 0.8 0.3
Asthma (self-reported) 0.3 0.6 2.6 1.6 -0.8 -0.0 0.3 0.8 0.3 0.4 0.8
Osteoporosis (self-reported) 0.1 0.2 0.6 -0.8 -0.1 0.5 0.3 0.5 0.2 -0.2 -0.1
Osteoarthritis (self-reported) 0.3 0.4 1.7 -0.5 0.2 -0.0 0.3 1.3 0.2 1.0 -0.0
Medication: Aspirin 0.3 0.4 1.4 0.8 -1.2 -0.1 0.4 0.5 0.7 0.0 0.8
Medication: Gliclazide 1.0 1.2 2.2 -0.8 1.3 -1.2 -1.5 0.3 -1.2 -0.8 -1.2
Illnesses of father: None of the above (group 1) 1.6 2.0 4.0 1.8 -2.0 1.1 1.5 0.0 1.5 0.8 1.4
Smoking status: Current 0.3 0.4 2.5 0.4 -0.7 0.0 0.4 1.6 0.2 0.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 4.0 1.4 -1.3 1.0 2.0 0.7 1.5 1.9 0.7
Whole body water mass 0.6 3.4 8.8 1.1 -1.6 1.7 1.7 3.0 1.8 1.3 2.0
Leg predicted mass (right) 0.6 3.0 9.4 1.1 -1.4 1.5 1.6 3.1 1.7 1.1 1.7
Arm fat mass (left) 0.7 3.0 11.8 0.4 -1.5 1.0 1.6 3.4 1.7 1.0 1.6
Number of self-reported non-cancer illnesses 0.1 0.1 0.4 0.3 -0.3 0.2 -0.0 0.6 0.0 0.3 0.3
Average weekly champagne plus white wine intake 1.3 1.7 3.7 -1.3 1.2 -1.5 -1.1 -1.9 -1.1 -0.7 -1.3
Miserableness 0.2 0.4 2.4 0.1 -0.0 -0.4 0.0 1.5 0.2 0.6 -0.4
Guilty feelings 0.5 0.8 1.5 0.3 -1.0 0.5 1.1 1.2 1.0 0.4 1.0
Wears glasses or contact lenses 0.5 0.6 1.8 -0.4 0.6 -0.5 -0.8 1.3 -0.8 -0.5 -0.7
Ever taken oral contraceptive pill 3.1 3.4 8.4 1.9 -0.9 2.9 1.5 2.7 1.3 1.8 0.6
Hearing aid user 0.2 0.2 0.4 -0.3 -0.5 0.6 0.5 0.6 0.6 0.4 0.4
Mother’s age at death 0.6 0.8 2.9 -1.7 1.0 -0.0 -0.2 -0.3 -0.1 -0.2 -1.5
Financial situation satisfaction 0.2 0.2 0.8 -0.9 -0.1 0.1 -0.1 -0.6 0.0 -0.0 0.8
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.0 -0.2 0.5 0.1 -0.9 0.4 -0.9 -1.0 -0.5
Commuting to job workplace: Public transport 0.3 0.4 2.1 -0.1 0.3 0.7 0.3 1.5 0.2 0.4 -0.6
Eye problems/disorders: Glaucoma 0.9 1.1 5.2 -0.3 0.9 -0.4 -0.9 -2.3 -0.8 0.1 -0.8
Medication: Blood pressure 0.3 0.6 2.6 0.3 -0.9 0.5 0.4 -1.6 0.6 0.4 0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.6 -0.1 0.3 0.4 0.9 0.5 0.8 0.1
Supplements: Fish oil (including cod liver oil) 2.5 3.2 5.6 1.7 -1.7 1.7 2.2 1.0 2.4 1.6 1.7
High cholesterol (Self-reported) 0.3 0.5 1.2 0.9 -1.1 -0.0 0.7 -0.2 0.8 0.6 0.8
Medication: Bendroflumethiazide 0.1 0.2 0.6 0.1 -0.3 -0.5 -0.2 -0.8 0.1 -0.2 0.5
Medication: Paracetamol 1.8 2.8 3.6 1.8 -1.9 1.6 1.9 1.6 1.7 1.6 1.4
Medication: Lisinopril 0.3 0.4 1.7 0.0 0.1 -1.3 -0.5 -0.6 -0.5 -0.5 -0.3
Medication: Atorvastatin 0.1 0.2 0.3 0.2 -0.5 -0.4 0.5 -0.5 0.6 -0.3 0.1
Illnesses of father: High blood pressure 0.8 1.0 1.6 -1.2 1.2 -0.8 -1.3 1.2 -1.2 -0.5 -0.3
Alcohol drinker status: Never 0.4 0.4 3.0 0.1 0.2 -0.1 -0.3 1.7 -0.4 -0.2 -0.4
Ever smoked 1.0 1.7 2.4 0.8 -1.5 0.5 1.3 -1.4 1.5 1.5 1.4
Basal metabolic rate 0.6 3.5 9.8 1.1 -1.6 1.6 1.7 3.1 1.8 1.3 2.0
Leg fat percentage (left) 1.4 5.2 10.9 1.6 -2.2 1.6 2.2 3.3 2.3 2.2 2.4
Arm fat-free mass (left) 1.0 4.9 9.1 1.6 -2.1 2.0 2.1 3.0 2.3 1.7 2.6
Number of operations (self-reported) 0.5 0.7 2.2 -0.9 1.0 -0.6 -0.5 0.2 -0.8 0.3 -1.5
Average weekly beer plus cider intake 1.3 1.8 2.5 1.2 -1.4 1.3 1.6 1.5 1.4 1.2 1.1
Irritability 1.0 1.6 7.3 -2.7 0.7 -1.7 -0.4 0.3 -0.3 0.9 -1.1
Risk taking 0.2 0.3 0.9 0.4 -0.2 -0.3 -0.5 0.9 -0.3 -0.3 0.8
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.9 -0.3 0.5 -0.4 -0.4 -0.3 -0.4 -0.6 -1.0
Fractured/broken bones in last 5 years 0.2 0.3 0.7 -0.7 0.0 -0.7 -0.3 -0.8 -0.0 -0.5 -0.2
Age started oral contraceptive pill 0.8 0.9 2.7 0.3 -0.6 1.6 1.1 -0.3 1.1 1.3 0.6
Diastolic blood pressure, automated reading 6.9 21.4 26.7 5.2 -5.0 3.4 5.2 2.9 5.0 5.0 4.7
Ever depressed for a whole week 0.3 0.3 1.2 -0.0 0.4 -0.4 0.1 1.1 0.0 0.0 -1.0
Unable to work because of sickness or disability 0.8 1.0 1.9 -1.4 0.9 -0.7 -0.8 1.3 -1.0 -1.1 -0.6
Commuting to job workplace: Cycle 0.5 0.6 1.1 -1.1 0.8 0.4 -0.8 -0.9 -0.8 -0.7 -0.9
Myopia 0.9 1.4 2.4 -0.5 1.3 -1.1 -1.3 -0.8 -1.6 -1.6 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.5 -0.9 0.6 0.9 0.3 1.2 -0.1 0.3 -0.8
Cholesterol lowering medication 0.1 0.2 0.6 -0.2 -0.4 -0.8 -0.2 -0.8 0.2 -0.1 0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.6 0.3 0.3 -0.8 -0.7 -0.2 -0.6 -0.3 -0.3
Pain experienced in last month 0.2 0.3 1.0 -0.2 0.2 0.3 -1.0 0.6 -0.7 -0.6 0.0
Supplements: Calcium 2.1 2.4 4.9 1.4 -1.3 1.6 1.3 2.2 1.3 1.5 1.3
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 1.0 0.1 -0.5 -0.4 0.4 -0.4 0.1 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.6 -0.3 0.0 -0.9 -0.3 -0.6 0.0 -1.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.7 -0.6 0.1 -0.5 0.1 -0.3 -0.0 -0.8 -0.1
Heart disease (siblings) 2.5 3.0 4.1 -1.3 1.9 -1.9 -2.0 -0.1 -2.0 -2.0 -1.8
Alcohol drinker status: Previous 1.0 1.1 3.3 0.0 1.0 -0.3 -0.6 1.7 -0.5 -0.9 -1.8
Pack years of smoking 0.3 0.4 2.1 0.3 -0.4 -0.2 0.2 1.4 0.4 0.8 0.1
Impedance of whole body 0.9 4.4 8.1 -1.5 2.0 -1.9 -2.0 -2.8 -2.0 -1.4 -2.5
Leg fat mass (left) 1.3 4.9 12.5 1.2 -2.0 1.5 2.2 3.5 2.3 1.9 2.3
Arm predicted mass (left) 1.0 5.3 9.3 1.6 -2.1 2.2 2.2 3.0 2.4 1.8 2.7