[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr17:6,397,773-9,565,411

Best TWAS P=6.28e-13 · Best GWAS P=1.58e-30 conditioned to 4.48e-18

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLC2A4	0.08	0.06	lasso	2	0.08	1.2e-09	-5.73	5.1	2.7e-07	-0.01	0.95	0.00	FALSE
2	GTEx	Adipose Subcutaneous	ELP5	0.35	0.38	enet	13	0.40	1.7e-34	-5.70	-5.4	6.5e-08	-0.04	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	CTDNEP1	0.12	0.08	lasso	2	0.09	1.7e-07	-5.61	5.7	1.1e-08	0.03	0.99	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	ELP5	0.49	0.56	lasso	6	0.55	1.3e-33	-5.75	-5.8	6.4e-09	-0.03	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	CLDN7	0.25	0.14	enet	21	0.12	7.3e-07	-5.61	-5.6	2.8e-08	-0.02	0.98	0.00	FALSE
6	GTEx	Adrenal Gland	ELP5	0.52	0.44	lasso	7	0.43	9.0e-17	-5.70	-5.5	2.9e-08	-0.05	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	CLDN7	0.30	0.10	lasso	5	0.12	5.6e-05	-5.61	6.0	2.5e-09	0.02	0.56	0.03	FALSE
8	GTEx	Artery Aorta	ACADVL	0.10	0.09	lasso	3	0.10	2.4e-06	-5.45	-5.1	3.1e-07	-0.03	0.92	0.01	FALSE
9	GTEx	Artery Aorta	ELP5	0.51	0.56	lasso	3	0.57	1.8e-37	-5.67	-5.8	6.2e-09	-0.03	1.00	0.00	FALSE
10	GTEx	Artery Aorta	CTDNEP1	0.16	0.09	lasso	3	0.06	2.4e-04	-5.66	5.6	1.7e-08	0.02	0.68	0.02	FALSE
11	GTEx	Artery Coronary	ELP5	0.64	0.55	lasso	9	0.55	7.2e-22	-5.70	-5.7	1.1e-08	-0.04	1.00	0.00	FALSE
12	GTEx	Artery Tibial	ELP5	0.49	0.55	lasso	6	0.57	2.6e-54	-5.75	-5.8	5.3e-09	-0.04	1.00	0.00	FALSE
13	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	-6.98	-7.0	3.0e-12	0.28	0.76	0.02	FALSE
14	GTEx	Brain Caudate basal ganglia	ELP5	0.64	0.57	enet	13	0.59	1.1e-20	-5.75	-5.3	1.0e-07	-0.05	1.00	0.00	FALSE
15	GTEx	Brain Frontal Cortex BA9	ELP5	0.31	0.20	lasso	7	0.19	9.3e-06	-5.75	-5.5	4.0e-08	-0.02	0.27	0.08	FALSE
16	GTEx	Brain Hippocampus	ELP5	0.52	0.22	lasso	6	0.23	3.4e-06	-5.67	-5.3	1.0e-07	-0.02	0.43	0.04	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	ELP5	0.44	0.39	lasso	7	0.38	5.2e-11	-5.75	-5.7	1.3e-08	-0.04	0.98	0.00	FALSE
18	GTEx	Brain Putamen basal ganglia	ELP5	0.67	0.38	lasso	11	0.39	2.6e-10	-5.75	-6.4	1.7e-10	-0.01	0.90	0.01	FALSE
19	GTEx	Breast Mammary Tissue	CHRNB1	0.23	0.07	enet	19	0.14	1.6e-07	2.89	-5.5	3.1e-08	0.12	0.73	0.01	FALSE
20	GTEx	Breast Mammary Tissue	ELP5	0.45	0.51	lasso	8	0.48	7.1e-28	-5.75	-5.7	1.6e-08	-0.04	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue (Male)	ELP5	0.38	0.43	lasso	6	0.42	6.4e-11	-5.67	-5.8	7.7e-09	-0.03	0.98	0.00	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	ELP5	0.40	0.28	lasso	10	0.23	3.5e-08	-5.75	-5.3	9.3e-08	-0.03	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	-3.12	-6.4	2.1e-10	0.26	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	ELP5	0.48	0.55	lasso	7	0.58	2.9e-53	-5.75	-5.8	6.8e-09	-0.04	1.00	0.00	FALSE
25	GTEx	Cells Transformed fibroblasts	CTDNEP1	0.11	0.07	lasso	4	0.10	1.1e-07	-5.61	5.6	2.0e-08	0.05	1.00	0.00	FALSE
26	GTEx	Colon Sigmoid	ELP5	0.55	0.55	lasso	7	0.51	7.0e-21	-5.70	-5.8	7.8e-09	-0.04	1.00	0.00	FALSE
27	GTEx	Colon Transverse	ELP5	0.58	0.59	lasso	4	0.56	4.7e-32	-5.70	-5.7	1.2e-08	-0.03	1.00	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	ELP5	0.68	0.61	lasso	5	0.58	1.6e-25	-5.70	-5.7	9.3e-09	-0.04	1.00	0.00	FALSE
29	GTEx	Esophagus Mucosa	CD68	0.30	0.19	lasso	5	0.17	2.5e-11	4.70	5.1	2.8e-07	-0.11	1.00	0.00	FALSE
30	GTEx	Esophagus Mucosa	SAT2	0.15	0.01	enet	18	0.02	1.2e-02	4.10	5.8	4.8e-09	-0.15	0.51	0.03	FALSE
31	GTEx	Esophagus Mucosa	ELP5	0.59	0.67	lasso	7	0.66	2.7e-58	-5.75	-5.8	8.2e-09	-0.04	1.00	0.00	FALSE
32	GTEx	Esophagus Mucosa	CTDNEP1	0.21	0.17	lasso	6	0.17	2.3e-11	-5.61	5.7	1.4e-08	0.04	1.00	0.00	FALSE
33	GTEx	Esophagus Muscularis	ELP5	0.52	0.52	lasso	4	0.53	6.4e-37	-5.70	-5.5	4.5e-08	-0.04	1.00	0.00	FALSE
34	GTEx	Heart Atrial Appendage	ELP5	0.42	0.44	lasso	3	0.44	6.3e-22	-5.70	-5.5	4.3e-08	-0.04	1.00	0.00	FALSE
35	GTEx	Heart Left Ventricle	ELP5	0.41	0.48	lasso	3	0.46	4.0e-27	-5.70	-5.7	1.4e-08	-0.04	1.00	0.00	FALSE
36	GTEx	Liver	ELP5	0.38	0.34	lasso	4	0.32	1.2e-09	-5.75	-5.7	9.2e-09	-0.04	0.96	0.00	FALSE
37	GTEx	Lung	ELP5	0.35	0.43	enet	18	0.44	2.7e-36	-5.70	-6.1	9.5e-10	-0.02	1.00	0.00	FALSE
38	GTEx	Muscle Skeletal	DLG4	0.12	0.05	lasso	4	0.05	2.3e-05	-5.45	5.1	2.7e-07	0.06	0.92	0.01	FALSE
39	GTEx	Muscle Skeletal	ELP5	0.46	0.59	lasso	9	0.60	1.9e-73	-5.70	-5.8	8.6e-09	-0.04	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	CLDN7	0.13	0.08	lasso	7	0.09	9.8e-09	-5.61	-5.5	3.0e-08	-0.04	1.00	0.00	FALSE
41	GTEx	Nerve Tibial	ELP5	0.44	0.50	lasso	8	0.50	4.3e-40	-5.70	-5.9	4.6e-09	-0.03	1.00	0.00	FALSE
42	GTEx	Pancreas	ELP5	0.38	0.37	lasso	6	0.36	2.7e-16	-5.75	-5.7	1.2e-08	-0.04	1.00	0.00	FALSE
43	GTEx	Pancreas	CLDN7	0.17	0.06	lasso	3	0.02	7.4e-02	-5.70	6.5	8.6e-11	0.02	0.18	0.04	TRUE
44	GTEx	Prostate	ELP5	0.65	0.43	lasso	10	0.44	1.6e-12	-5.70	-6.0	2.7e-09	-0.02	0.98	0.00	FALSE
45	GTEx	Prostate	AC113189.5	0.43	0.02	lasso	5	0.01	2.0e-01	-6.57	6.2	7.1e-10	-0.13	0.06	0.05	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	ELP5	0.51	0.55	enet	22	0.55	6.1e-36	-5.70	-5.5	3.1e-08	-0.04	1.00	0.00	FALSE
47	GTEx	Skin Sun Exposed Lower leg	DVL2	0.10	0.03	lasso	2	0.02	1.5e-02	-5.45	-5.4	7.5e-08	-0.03	0.84	0.01	FALSE
48	GTEx	Skin Sun Exposed Lower leg	ELP5	0.49	0.51	enet	34	0.54	3.1e-52	-5.75	-5.6	2.0e-08	-0.04	1.00	0.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	CTDNEP1	0.10	0.06	lasso	6	0.06	9.5e-06	-5.61	6.0	2.8e-09	0.04	0.80	0.02	FALSE
50	GTEx	Spleen	ELP5	0.67	0.47	lasso	6	0.46	2.2e-13	-5.70	-5.7	1.5e-08	-0.04	1.00	0.00	FALSE
51	GTEx	Spleen	CLDN7	0.51	0.26	lasso	10	0.26	2.6e-07	-5.61	-5.4	5.7e-08	-0.04	0.91	0.01	FALSE
52	GTEx	Stomach	ELP5	0.49	0.54	lasso	7	0.52	7.6e-29	-5.70	-5.8	8.7e-09	-0.04	1.00	0.00	FALSE
53	GTEx	Testis	PIK3R5	0.42	0.40	lasso	3	0.40	3.9e-19	-5.94	5.9	3.6e-09	0.04	0.06	0.94	FALSE
54	GTEx	Testis	ELP5	0.48	0.42	enet	10	0.42	3.3e-20	-5.70	-5.4	7.4e-08	-0.05	1.00	0.00	FALSE
55	GTEx	Testis	PIK3R6	0.40	0.35	lasso	5	0.39	1.6e-18	-5.98	-6.2	7.9e-10	0.01	0.05	0.95	TRUE
56	GTEx	Thyroid	ELP5	0.46	0.56	lasso	9	0.56	1.6e-50	-5.75	-5.7	1.3e-08	-0.04	1.00	0.00	FALSE
57	GTEx	Thyroid	CLDN7	0.08	0.08	lasso	1	0.06	1.2e-05	-5.70	5.7	1.2e-08	0.04	0.93	0.00	FALSE
58	GTEx	Uterus	ELP5	0.52	0.51	lasso	1	0.48	3.0e-11	-5.78	-5.8	7.5e-09	0.01	0.91	0.01	FALSE
59	GTEx	Whole Blood	ELP5	0.23	0.16	enet	13	0.18	4.8e-16	-5.68	-6.0	2.7e-09	-0.03	1.00	0.00	FALSE
60	METSIM	Adipose	CHD3	0.06	0.03	blup	509	0.02	6.7e-04	0.55	-5.5	4.2e-08	0.30	0.26	0.08	FALSE
61	METSIM	Adipose	CTDNEP1	0.12	0.11	lasso	5	0.11	2.3e-16	-5.61	5.9	4.5e-09	0.02	1.00	0.00	FALSE
62	METSIM	Adipose	ELP5	0.24	0.28	lasso	11	0.28	1.4e-42	-5.75	-6.0	2.2e-09	-0.03	1.00	0.00	FALSE
63	METSIM	Adipose	FGF11	0.07	0.00	bslmm	477	0.02	1.5e-04	-3.81	5.6	1.7e-08	-0.15	0.74	0.03	TRUE
64	METSIM	Adipose	GPS2	0.09	0.08	lasso	2	0.07	4.1e-11	5.14	5.3	1.4e-07	-0.05	1.00	0.00	FALSE
65	NTR	Blood	ACAP1	0.02	0.00	blup	437	0.01	6.9e-03	-5.78	6.0	1.5e-09	-0.10	0.06	0.02	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	SOX15	0.14	0.09	enet	30	0.09	2.6e-11	-6.21	5.2	2.6e-07	-0.20	1.00	0.00	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	ELP5	0.44	0.52	enet	35	0.55	2.1e-84	-5.66	-5.6	2.5e-08	-0.04	1.00	0.00	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	CTDNEP1	0.23	0.30	bslmm	447	0.31	5.7e-40	-5.61	5.2	2.2e-07	0.05	1.00	0.00	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	SLC2A4	0.08	0.08	enet	9	0.08	5.5e-11	-4.45	5.8	6.1e-09	0.02	1.00	0.00	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	CLDN7	0.07	0.06	lasso	4	0.05	3.9e-07	-5.40	-5.3	1.2e-07	-0.04	0.97	0.00	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	AC113189.5	0.11	0.06	lasso	6	0.06	2.1e-08	-6.30	6.5	5.7e-11	-0.18	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C17orf81	0.10	0.17	lasso	7	0.17	3.4e-14	-5.75	-6.0	1.7e-09	-0.03	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DULLARD	0.04	0.07	lasso	2	0.05	3.3e-05	-5.61	5.4	7.0e-08	0.04	0.03	0.96	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	DULLARD	0.03	0.07	enet	13	0.07	5.8e-15	-5.61	5.6	1.8e-08	0.02	0.02	0.98	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-2.08	-5.2	1.5e-07	0.08	0.00	0.02	TRUE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf81	0.05	0.12	lasso	5	0.11	1.8e-12	-5.61	-5.6	2.5e-08	-0.03	0.02	0.98	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DULLARD	0.07	0.10	blup	42	0.12	1.1e-13	-5.62	5.2	2.4e-07	0.04	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	DULLARD	0.07	0.07	enet	12	0.10	2.0e-11	-5.68	5.8	5.2e-09	0.02	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	SHBG	0.05	0.02	lasso	3	0.02	8.1e-04	-6.57	7.0	2.1e-12	-0.16	0.01	0.93	FALSE
80	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C17orf81	0.10	0.07	blup	44	0.11	8.1e-06	-5.75	-5.8	6.2e-09	-0.03	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	C17orf81	0.05	0.06	blup	43	0.06	6.4e-08	-5.75	-5.7	1.4e-08	-0.04	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	DULLARD	0.04	0.06	blup	42	0.08	3.3e-09	-5.66	5.2	2.2e-07	0.04	0.02	0.98	FALSE
83	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C17orf81	0.06	0.12	lasso	8	0.12	6.3e-14	-5.45	-5.5	3.1e-08	-0.03	0.03	0.97	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF5A	0.03	0.03	blup	52	0.03	4.2e-04	4.56	6.0	2.6e-09	-0.05	0.34	0.40	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf81	0.17	0.15	lasso	5	0.16	5.0e-07	-5.67	-5.8	8.6e-09	-0.03	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DULLARD	0.10	0.10	enet	8	0.10	7.7e-05	-5.45	5.8	6.1e-09	0.03	0.03	0.96	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	C17orf81	0.11	0.21	lasso	8	0.21	4.5e-22	-5.67	-5.8	6.1e-09	-0.03	0.02	0.98	FALSE
88	The Cancer Genome Atlas	Rectum Adenocarcinoma	DULLARD	0.15	0.10	blup	41	0.11	1.4e-03	-5.61	5.5	3.0e-08	0.06	0.03	0.68	FALSE
89	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C17orf81	0.35	0.24	enet	12	0.25	2.1e-07	-5.34	-5.7	1.6e-08	-0.03	0.03	0.97	FALSE
90	The Cancer Genome Atlas	Skin Cutaneous Melanoma	DLG4	0.12	0.10	lasso	1	0.08	3.1e-03	-5.66	-5.7	1.5e-08	-0.02	0.01	0.59	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf81	0.03	0.02	blup	47	0.02	1.3e-02	-5.75	-5.3	1.0e-07	-0.04	0.02	0.95	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	DULLARD	0.03	0.04	lasso	1	0.03	1.8e-03	-5.62	5.6	1.9e-08	0.04	0.02	0.90	FALSE
93	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EIF5A	0.20	0.14	blup	53	0.15	5.1e-06	4.57	5.7	1.3e-08	-0.05	0.19	0.44	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf81	0.19	0.23	lasso	5	0.24	1.4e-23	-5.75	-5.6	1.8e-08	-0.04	0.02	0.98	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	CLDN7	0.05	0.06	blup	47	0.05	5.2e-06	-5.67	5.2	2.5e-07	0.05	0.02	0.98	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	DULLARD	0.10	0.18	lasso	7	0.19	2.6e-18	-5.73	5.8	6.1e-09	0.02	0.02	0.98	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	FXR2	0.04	0.03	lasso	1	0.02	1.8e-03	-7.19	-7.2	6.3e-13	0.18	0.00	0.96	TRUE
98	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	-7.19	-5.9	3.7e-09	0.15	0.00	0.99	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	TRAPPC1	0.12	0.02	lasso	4	0.05	2.6e-05	4.38	-5.5	4.1e-08	0.20	0.28	0.03	TRUE
100	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C17orf81	0.19	0.06	blup	42	0.10	1.2e-03	-5.75	-5.4	7.1e-08	-0.05	0.02	0.87	FALSE