Hub : Genes

ZMYND15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.3450 0.1040 2.8e-03 -0.005 NA 0.039 NA 0.004 5.9e-01 NA 7.9e-03 NA 1.9e-01
2 YFS Blood 0.2179 0.0287 0.0e+00 0.082 0.140 0.152 0.159 0.142 1.5e-25 2.3e-43 2.2e-47 1.4e-49 4.6e-44
3 TCGA Breast Invasive Carcinoma 0.0421 0.0153 1.2e-05 0.008 0.029 0.031 NA 0.020 6.1e-03 9.9e-07 4.2e-07 NA 4.1e-05
4 TCGA Kidney Renal Clear Cell Carcinoma 0.1092 0.0401 3.4e-05 0.019 0.022 0.026 NA 0.028 3.0e-03 1.3e-03 5.9e-04 NA 3.7e-04
5 TCGA Brain Lower Grade Glioma 0.0573 0.0274 3.6e-03 0.022 0.018 0.003 NA 0.008 1.2e-03 3.5e-03 1.3e-01 NA 3.5e-02
6 TCGA Liver Hepatocellular Carcinoma 0.1870 0.0760 1.3e-03 0.016 0.039 0.013 NA 0.012 5.9e-02 6.2e-03 8.0e-02 NA 8.8e-02
7 TCGA Skin Cutaneous Melanoma 0.1430 0.0770 7.1e-03 0.015 0.040 -0.011 NA 0.013 1.2e-01 3.1e-02 9.7e-01 NA 1.4e-01
8 TCGA Thyroid Carcinoma 0.0450 0.0230 9.0e-03 0.017 0.001 0.002 NA 0.006 7.1e-03 2.3e-01 1.8e-01 NA 7.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.7 1.2 3.5 -0.2 -1.9 -1.6 -0.0 -0.7 -0.3 -0.8 -1.4
Bipolar Disorder or Schizophrenia 0.5 1.3 2.9 -1.1 -1.7 -1.5 -0.3 -1.1 -0.5 -1.1 -1.1
Depressed Affect (Nagel 2018) 0.4 0.9 3.7 -1.9 0.4 -1.1 0.2 0.1 1.4 0.2 -0.2
Depression (Nagel 2018) 1.5 2.2 5.9 -2.4 1.3 0.4 1.4 1.0 1.5 1.8 1.3
Intelligence (Savage-Jansen 2018) 0.5 1.4 3.7 0.7 -1.9 1.0 0.1 1.7 -1.7 0.6 -0.3
Neuroticism (Nagel 2018) 0.4 0.9 3.3 -1.8 0.7 -1.0 -0.5 -0.7 1.1 -0.2 -0.7
Schizophrenia (2018) 0.2 0.4 1.1 -1.0 -0.7 -0.5 -0.4 -0.9 -0.4 -0.7 -0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.8 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.4 0.9 2.4 -0.4 1.5 -0.7 -1.1 -0.7 1.2 -0.2 -0.8
Alzheimer’s Disease (in mother) 0.7 0.8 4.5 -0.3 0.7 0.7 0.4 -0.3 -2.1 -0.5 0.2
Alzheimer’s Disease (in father) 0.4 0.5 1.8 -0.3 -0.2 -0.7 0.1 -0.4 1.4 -1.1 0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 1.2 -0.2 0.4 -0.0 0.2 -0.1 -1.1 -1.1 0.1
Crohns Disease (2017) 0.7 1.5 4.2 0.4 0.9 0.1 2.1 1.8 1.0 0.7 1.5
Irritable Bowel Disease (IBD) 1.1 2.7 5.2 -0.6 1.7 -0.2 2.3 2.2 1.4 2.0 1.6
Ulcerative Colitis (UC) 1.1 2.1 5.5 -0.7 1.7 -0.1 1.5 1.8 1.3 2.3 1.0
Major Depression (MDD) 0.2 0.2 0.5 0.4 -0.0 0.2 -0.7 0.1 -0.7 -0.7 -0.1
Reaction Time 0.2 0.4 1.4 -0.3 0.1 -0.8 -0.3 -0.8 -0.6 -1.2 -0.2
Verbal and Numeric Reasoning (VNR) 0.6 1.6 2.9 1.4 -1.6 1.1 0.7 1.7 -1.1 1.5 -0.1
Breast Cancer 0.3 0.7 2.0 0.9 0.9 0.5 -0.3 0.9 1.4 -0.2 0.8
Ovarian Cancer 0.3 0.4 1.2 1.1 -0.1 0.5 -0.0 0.7 -0.8 -0.5 0.2
Prostate Cancer 0.1 0.2 0.8 0.3 -0.4 -0.1 -0.0 -0.9 -0.1 0.5 -0.0
Age at First Birth 0.2 0.3 0.8 0.9 0.0 0.4 0.5 0.7 -0.8 -0.4 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.1 0.8 -1.5 -1.3 -0.1 -0.9 0.2 -0.1 -1.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.5 2.4 5.9 -1.2 1.2 0.3 2.4 1.9 1.4 1.2 1.9
Mean Putamen Volume 0.8 0.9 3.2 0.6 0.6 1.8 0.9 0.9 -0.4 0.3 1.2
Fasting Glucose 0.8 1.0 3.5 -1.9 -1.3 -1.0 0.5 -0.7 -0.6 -0.9 -0.0
HbA1C 0.2 0.2 0.9 -0.5 -0.3 0.4 -0.2 -0.2 1.0 -0.0 -0.7
HDL Cholesterol 1.6 2.7 6.5 -1.0 2.6 0.8 2.3 2.1 -0.5 0.2 1.8
LDL Cholesterol 0.9 1.4 5.3 -0.0 1.2 -0.2 0.4 1.2 2.3 1.7 0.3
Lupus 0.8 1.2 3.0 -0.2 -1.1 -1.7 -0.9 -0.5 1.3 1.1 -1.3
Neuroticism (2016) 1.2 1.8 7.0 -0.2 0.6 -1.5 -0.9 -1.1 2.6 1.1 -1.2
Primary Biliary Cirrhosis 0.4 0.6 1.6 0.7 -0.7 -0.6 -1.3 -0.4 -0.3 0.4 -1.1
Rheumatoid Arthritis 0.5 0.7 2.2 1.5 -0.7 -0.2 -0.6 -0.9 0.1 0.4 -1.2
Schizophrenia (2014) 0.2 0.4 1.3 -0.9 -0.7 0.3 0.0 -0.4 -1.1 -0.7 -0.2
Triglycerides 1.3 2.1 10.5 -0.0 -3.2 -0.9 -1.4 -0.5 -0.6 0.6 -1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.7 1.0 3.4 -1.8 1.5 0.4 0.9 0.0 0.0 0.0 1.0
Blood Eosinophil Count 2.3 17.7 47.6 5.2 -3.8 1.8 -3.2 -2.7 -6.9 -5.1 -2.2
Blood Platelet Count 0.1 1.6 4.1 -1.4 1.3 -0.3 2.0 1.3 0.8 1.4 0.7
Blood Red Count 0.0 0.5 2.4 1.0 1.6 -0.4 -0.0 -0.1 0.4 -0.3 0.1
Blood White Count 2.1 15.9 37.8 1.6 4.3 1.8 3.8 3.4 4.7 6.2 4.2
Heel T-Score 0.6 4.7 7.8 0.5 2.3 2.4 2.1 2.5 1.1 2.6 2.8
BMI 0.5 2.8 7.1 -0.0 0.7 1.0 2.7 2.1 0.9 2.3 1.7
Height 0.0 0.9 3.5 -0.5 1.9 0.0 0.7 1.0 1.1 0.7 0.7
Waist Hip Ratio (WHR) 0.5 2.3 6.6 1.2 2.6 2.0 0.6 1.2 1.2 1.4 1.2
Systolic Blood Pressure 0.2 0.8 3.7 -0.3 0.8 0.5 0.2 1.2 0.7 1.9 -0.1
Smoking Status 0.4 0.9 1.9 -0.4 -0.7 1.0 1.0 1.1 -0.8 1.4 0.9
Allergy or Eczema 0.4 1.0 2.9 1.4 -1.2 -0.1 -1.0 0.1 -0.2 0.4 -1.7
Cardiovascular Disease 0.1 0.2 0.9 -0.2 0.5 0.9 0.4 0.2 -0.5 0.4 0.2
Hypothyroidism (self reported) 0.3 0.6 2.8 0.0 0.8 -0.4 1.7 1.1 0.4 0.2 0.4
Respiratory disease 0.2 0.4 2.6 -0.5 0.2 0.0 0.2 0.5 -0.3 1.6 -0.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.5 -0.1 -0.6 0.3 -0.9 -0.9 -1.6 -1.9 -1.0
Lung FEV1/FVC ratio 0.5 2.3 5.6 0.2 -0.2 1.5 2.4 1.3 -0.6 2.1 2.1
Lung FVC 0.1 0.5 1.6 -1.3 0.5 -0.2 -0.5 -0.1 0.0 1.2 0.1
Neuroticism 0.8 1.9 6.2 -2.5 0.6 -1.2 -0.6 -1.4 2.1 -0.1 -1.0
Chronotype (morning person) 0.5 1.2 2.9 -1.7 -1.2 -0.6 -0.7 -0.7 -0.5 -1.5 -1.3
Hair Pigment 0.0 0.2 0.6 -0.6 -0.8 -0.3 0.6 -0.1 0.2 -0.1 -0.2
Tanning 0.1 1.8 4.0 0.7 1.0 1.9 1.7 1.3 -0.6 0.6 2.0
Hand grip strength (left) 0.4 1.0 2.6 -0.3 1.6 0.4 0.9 1.5 0.7 0.8 1.0
Number of treatments/medications taken 0.3 0.5 2.1 -0.3 0.5 -0.3 0.9 -0.2 0.6 1.5 0.0
Average weekly spirits intake 0.3 0.3 1.3 -1.1 -0.3 -0.0 0.8 -0.3 -0.5 -0.6 0.3
Sensitivity / hurt feelings 0.1 0.2 0.4 -0.3 -0.7 -0.1 -0.2 -0.6 -0.4 -0.2 -0.3
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.9 -1.4 0.2 0.1 0.4 -0.2 0.2 0.7 0.1
Hearing difficulty/problems: Yes 2.1 3.3 6.2 -1.9 1.5 1.6 2.1 1.6 0.4 2.5 2.1
Relative age of first facial hair 0.5 1.0 3.9 2.0 -0.3 1.0 0.0 0.5 -0.5 1.6 0.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.6 -0.2 -1.2 -0.1 -1.0 -0.7 -0.2 -0.1 -1.0
Ever used hormone-replacement therapy (HRT) 1.0 1.3 5.6 -2.4 0.7 -0.4 1.0 0.5 1.5 0.8 -0.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.9 -0.5 0.4 -0.2 -0.9 -0.6 0.4 0.1 -0.8
Systolic blood pressure, automated reading 0.9 2.7 8.2 -1.5 1.8 0.5 1.0 2.0 1.4 2.9 0.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.0 -0.1 0.1 1.0 1.4 1.7 -1.6 1.3 0.0
Angina 0.2 0.2 0.7 0.1 0.0 0.7 -0.8 -0.4 0.0 0.6 -0.1
Medication for hormone replacement therapy 0.1 0.2 0.5 0.4 -0.6 0.3 0.7 0.1 -0.2 0.2 0.1
Vitamin and mineral supplements 0.3 0.3 2.4 1.6 -0.2 0.2 -0.2 0.2 -0.1 -0.3 -0.2
Supplements: Zinc 0.2 0.2 0.7 0.0 -0.1 0.2 -0.7 -0.5 0.3 0.8 -0.5
Medication: Co-codamol 0.8 1.0 6.0 -2.5 0.4 -0.4 0.9 -0.3 -0.3 -0.4 0.4
Medication: Metformin 1.3 1.8 3.8 -0.3 -1.6 -0.4 -1.4 -1.1 -1.7 -1.2 -1.9
Diabetes (father) 1.1 1.3 3.8 0.2 0.7 1.1 1.9 1.1 -0.6 -0.6 1.7
Diabetes (mother) 1.8 2.3 8.5 -0.3 -2.9 -1.6 0.9 -0.7 -1.3 -2.0 -0.5
Severe depression (siblings) 0.9 1.0 2.7 -0.7 -0.4 -0.8 -0.5 -1.6 1.0 -1.6 -0.7
Pack years adult smoking proportion 0.1 0.2 0.5 0.4 -0.4 -0.0 -0.5 -0.0 -0.7 0.3 -0.4
Impedance of leg (right) 0.2 1.1 2.2 1.3 -0.3 -0.3 -1.5 -1.5 -0.5 -1.3 -0.9
Leg fat-free mass (left) 0.2 0.8 2.0 -0.2 0.8 0.6 1.4 1.3 0.6 1.0 0.7
Trunk fat percentage 0.1 0.3 0.9 -0.0 -0.8 -0.6 0.9 0.3 0.1 0.1 -0.4
Hand grip strength (right) 0.4 1.1 2.8 -0.6 1.7 0.6 0.9 1.3 1.4 0.9 0.7
Townsend deprivation index at recruitment 1.6 2.3 6.5 -1.7 -1.3 -2.5 0.1 -1.7 -0.7 -1.5 -1.3
Current tobacco smoking 0.1 0.2 0.9 -0.4 -0.6 0.0 0.3 -0.6 -0.9 -0.2 0.0
Average weekly fortified wine intake 0.1 0.2 0.3 -0.1 -0.0 0.3 -0.4 0.5 -0.5 -0.5 -0.6
Maternal smoking around birth 1.3 1.9 4.8 -0.3 0.9 1.9 1.3 1.1 0.6 1.7 2.2
Fed-up feelings 0.6 1.2 6.2 -2.5 0.6 -0.2 1.3 0.4 0.8 0.4 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 5.2 -2.3 -0.1 -0.4 0.4 -0.4 1.4 0.6 0.2
Relative age voice broke 0.2 0.3 1.8 0.3 0.5 0.1 0.1 0.5 -0.5 1.3 0.3
Taking other prescription medications 0.1 0.1 0.7 0.1 0.1 -0.2 0.2 -0.8 0.1 0.4 -0.4
Age when periods started (menarche) 0.6 1.5 5.1 -1.9 0.4 -0.6 -0.8 0.4 1.3 2.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 -1.1 0.1 -0.7 -0.9 -1.2 0.2 -1.4 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 4.8 -0.1 0.8 2.1 -1.6 1.1 2.2 2.1 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.0 -0.4 0.2 -0.8 -0.3 -1.0 1.0 -0.6 -0.5
Qualifications: CSEs or equivalent 0.6 0.8 2.9 -0.4 -0.6 0.2 1.6 0.4 -1.7 -0.0 0.4
Serious illness, injury or assault to yourself 2.2 2.7 4.8 -1.6 -1.0 -2.0 -2.2 -2.2 1.6 -0.9 -1.1
High blood pressure 0.4 1.2 4.0 1.2 0.9 2.0 -0.6 0.4 -0.8 1.5 0.1
Hayfever, allergic rhinitis or eczema 0.2 0.3 1.3 0.4 -0.4 -0.5 -0.5 -0.2 1.1 0.3 -0.8
Multivitamins +/- minerals 0.3 0.4 1.2 -0.7 0.8 -0.2 0.2 -0.0 1.1 0.4 0.7
Stomach or abdominal pain in last month 0.4 0.5 1.4 -0.9 -0.1 0.3 1.2 0.2 -0.9 -0.7 0.2
Supplements: Glucosamine 0.4 0.5 1.4 -1.2 0.7 -0.7 0.2 0.6 1.2 0.1 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.9 0.0 0.4 -0.2 -0.7 -0.4 0.5 1.0 -0.3
Medication: Atenolol 1.0 1.2 2.5 0.2 1.4 1.0 0.4 0.9 1.6 1.3 1.1
Medication: Levothyroxine sodium 0.2 0.3 0.7 0.7 0.4 -0.4 0.7 0.3 0.9 0.2 0.2
Sitting height 0.2 1.7 6.1 -1.9 1.6 0.1 -0.0 0.7 2.5 1.1 -0.0
Chronic bronchitis/emphysema (father) 0.7 0.8 2.6 -0.2 -0.8 -1.6 -0.2 -0.5 -0.9 -1.1 -0.8
High blood pressure (mother) 0.8 1.1 2.9 -1.3 -0.1 0.9 -0.9 -0.5 -1.6 -1.7 -0.1
Body mass index (BMI) 0.2 0.9 3.6 -0.4 -0.5 -0.2 1.9 1.2 -0.0 1.3 0.5
Impedance of leg (left) 0.2 0.8 1.8 0.9 -0.4 -0.2 -1.3 -1.0 -0.5 -1.2 -0.8
Leg predicted mass (left) 0.2 0.9 2.2 -0.1 0.9 0.7 1.5 1.4 0.5 1.2 0.8
Trunk fat mass 0.1 0.3 0.9 -0.0 -0.6 -0.5 1.0 0.4 0.2 0.3 -0.4
Waist circumference 0.2 0.9 2.0 0.3 0.7 0.8 1.4 1.3 0.4 1.3 0.7
Number of incorrect matches in round 1.3 2.2 7.0 -1.7 0.5 -1.3 -1.2 -1.8 2.7 -0.2 -1.1
Past tobacco smoking 0.3 0.6 2.2 0.8 0.4 -0.7 0.0 -0.6 -0.3 -1.5 -0.7
Alcohol usually taken with meals 1.2 1.9 5.4 1.4 0.6 1.0 1.5 2.3 -0.5 1.3 1.5
Nervous feelings 0.7 1.4 3.7 -0.4 -0.1 -1.9 -1.6 -0.9 0.4 -1.1 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.6 -1.3 -0.7 -0.9 -0.5 -0.3 0.4 0.7 -1.2
Hearing difficulty/problems with background noise 1.1 1.7 5.3 -2.2 0.7 -1.0 -0.1 -0.2 2.3 1.2 -0.4
Hair/balding pattern: Pattern 2 1.3 1.6 3.4 -1.4 -0.6 -0.1 1.8 0.4 -1.7 -1.9 0.9
Had menopause 0.7 0.9 2.5 -1.5 0.7 -0.0 1.1 0.3 0.7 0.2 1.6
Had other major operations 1.2 1.4 4.3 -1.8 0.7 0.7 2.1 0.6 -0.3 1.0 1.3
Forced vital capacity (FVC) 0.1 0.3 0.6 0.1 -0.3 0.4 -0.6 0.4 -0.8 0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 5.8 0.7 0.6 2.1 -1.2 1.8 2.4 2.2 -0.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.5 -0.7 -0.6 -1.6 1.4 0.4 0.3 -1.0 0.2
Qualifications: None of the above 0.1 0.3 0.9 -0.8 -0.1 -0.2 -0.8 -0.9 0.1 -0.4 -0.2
Financial difficulties in last 2 years 1.2 1.6 3.9 -1.4 0.5 -0.8 2.0 0.9 1.3 1.0 1.4
Mouth/teeth dental problems 0.8 1.2 6.4 2.5 0.4 1.0 -0.9 -0.0 -0.7 -0.7 -0.4
Heart attack 0.6 0.8 3.2 1.8 -0.0 1.2 -0.6 0.2 -0.2 1.0 -0.4
Allergy 0.1 0.1 0.5 0.0 0.3 0.2 0.2 0.1 -0.1 -0.7 0.7
Pain all over the body in last month 0.3 0.3 1.8 -0.6 -1.3 0.2 -0.1 0.1 -0.6 0.1 -0.4
Diabetes (self-reported) 0.5 0.7 2.7 0.7 -0.6 0.2 -0.4 -0.9 -1.6 -0.8 -0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.4 -0.3 0.8 -0.3 0.3 -0.3 0.5 -1.2 0.3
Medication: Ramipril 0.9 1.2 5.8 2.4 -0.6 0.8 -0.5 -0.6 -1.4 -0.4 -0.1
Medication: Simvastatin 0.4 0.6 1.3 0.5 -0.5 0.9 1.1 0.9 -0.5 0.8 0.9
Fluid intelligence score 1.2 2.5 6.7 1.9 -0.9 1.2 1.1 2.2 -1.1 2.6 -0.0
Illnesses of siblings 0.8 1.1 2.1 1.2 -0.4 -1.4 -1.5 -0.6 -0.2 -1.4 -0.8
Neuroticism score 0.8 1.7 4.1 -2.0 0.5 -1.5 -0.5 -1.2 1.9 -0.5 -1.2
Weight 0.1 0.5 1.6 -0.0 0.0 -0.1 1.3 1.0 0.3 1.1 0.2
Impedance of arm (right) 0.5 2.2 4.8 1.5 -0.5 -0.5 -2.1 -1.7 -0.4 -2.2 -1.5
Arm fat percentage (right) 0.1 0.4 1.4 0.2 -1.0 -0.6 1.2 0.5 -0.4 0.1 -0.3
Trunk fat-free mass 0.2 1.2 2.2 0.1 1.4 0.8 1.3 1.5 0.9 1.4 0.8
Hip circumference 0.1 0.3 1.0 0.2 -0.7 -0.3 1.0 0.7 -0.6 0.2 -0.2
Time employed in main current job 2.6 3.0 7.9 -0.7 -0.4 -2.2 -1.9 -1.6 2.8 -1.4 -1.5
Alcohol intake versus 10 years previously 1.0 1.5 6.2 -0.5 -1.4 -1.7 0.5 -0.5 -2.5 -0.4 -0.6
Father’s age at death 0.1 0.1 0.3 -0.1 0.6 0.3 -0.3 0.5 -0.2 -0.3 0.0
Worrier / anxious feelings 1.0 1.9 5.2 -1.6 0.8 -2.3 -0.3 -1.4 1.6 -1.1 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 9.2 -0.0 -3.0 -0.6 -1.2 -1.7 -0.9 -0.5 -1.5
Falls in the last year 0.8 1.1 2.6 -1.0 -1.6 -0.6 -0.7 -0.5 -0.8 -1.5 -1.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.6 1.6 1.0 0.0 -1.1 -0.7 -0.4 0.1 -0.7
Number of live births 0.8 1.2 5.0 -1.2 0.2 0.1 2.2 0.6 0.3 0.2 1.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 1.0 0.4 -0.1 0.4 0.3 0.5 -0.4 1.0 0.3
Pulse rate 0.2 0.3 0.9 -0.7 0.1 0.2 1.0 0.3 0.1 0.9 -0.1
Happiness 3.7 4.5 7.5 -1.1 -1.6 -2.6 -2.0 -2.6 0.1 -2.7 -2.6
Noisy workplace 0.4 0.4 2.6 0.4 0.4 -0.3 0.0 -0.2 1.6 0.7 0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.8 0.3 -0.8 -0.4 0.1 0.6 -1.3 -0.5 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.1 -0.1 -0.5 -0.0 0.1 -0.4 -1.1 -0.6 -0.4
Mouth/teeth dental problems: Dentures 1.9 3.2 17.5 -4.2 1.0 -1.0 0.8 0.1 2.1 0.6 0.8
Asthma 0.4 0.7 1.8 -0.1 -0.3 -1.0 -1.3 -0.7 -0.2 0.9 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.3 -0.1 0.3 0.1 1.1 0.3 0.1 0.9 0.3
Medication: Cholesterol lowering 2.1 3.3 6.5 1.6 0.6 2.5 2.0 2.5 -0.6 1.8 1.8
Depression (self-reported) 0.6 0.7 2.4 -0.7 0.8 -0.3 -0.0 -0.6 1.2 -1.6 0.6
Medication: Lansoprazole 0.5 0.6 2.5 0.1 -1.0 0.1 -0.5 -0.6 -1.6 -0.2 -0.9
Prospective memory result 1.5 1.8 6.0 -2.4 -0.9 -0.4 -0.2 -1.6 -0.3 -2.0 -0.7
Lung cancer (father) 1.9 2.3 5.1 -0.2 1.5 0.9 1.3 1.2 2.2 1.9 1.8
Illnesses of mother 0.5 0.6 1.5 0.8 0.3 -0.6 -0.5 0.4 1.2 1.2 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.4 0.0 -0.1 0.2 0.1 0.2 0.1 0.7 0.4
Pulse wave Arterial Stiffness index 1.5 1.8 4.6 0.8 1.4 2.1 1.1 0.5 -0.2 1.4 1.9
Impedance of arm (left) 0.5 2.2 5.0 0.6 -1.0 -0.5 -2.2 -1.9 -0.4 -2.2 -1.6
Arm fat mass (right) 0.1 0.5 2.3 -0.1 -0.6 -0.4 1.5 0.7 -0.1 0.6 0.1
Trunk predicted mass 0.2 1.1 2.0 0.0 1.4 0.8 1.2 1.4 0.8 1.2 0.8
Standing height 0.0 0.4 1.1 0.4 1.1 0.1 -0.9 -0.2 0.7 -0.5 -0.4
Length of working week for main job 0.5 0.5 3.0 -0.6 0.5 0.6 -0.2 0.3 0.0 1.7 0.0
Exposure to tobacco smoke at home 1.6 1.8 6.2 -2.0 -0.6 -0.5 2.5 0.8 -1.2 -0.1 1.3
Breastfed as a baby 0.4 0.5 1.2 -0.7 0.4 0.7 -1.1 -0.5 -0.6 0.4 -0.8
Tense / ‘highly strung’ 1.2 2.1 5.0 -1.8 1.1 -1.1 -2.2 -1.2 0.7 -0.5 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.5 -1.2 -0.1 -0.9 0.3 -0.2 -0.2 -1.2 -0.2
Hair/balding pattern: Pattern 4 0.4 1.0 3.2 0.4 0.4 0.6 -0.8 -0.5 1.8 1.8 0.1
Birth weight of first child 0.3 0.6 1.5 -0.3 -0.6 -1.2 0.9 0.2 -0.0 -1.2 0.6
Peak expiratory flow (PEF) 0.3 0.6 1.8 0.5 -0.7 -0.2 -0.9 -0.2 0.6 1.3 -0.9
Pulse wave reflection index 0.7 0.9 2.1 -0.1 1.1 1.2 0.4 0.7 0.9 1.1 1.5
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.7 0.2 -0.1 -0.0 -0.2 -1.2 -0.2 -1.3 -0.2
Loud music exposure frequency 0.1 0.1 0.6 0.0 -0.0 0.2 0.1 0.1 0.8 0.4 0.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.6 1.3 -0.7 -0.4 -0.4 0.2 -0.2 -0.7 -0.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.5 0.5 -0.7 -0.3 -0.4 0.1 -0.0 -0.2 -0.6
Blood clot in the leg (DVT) 0.5 0.7 2.5 -0.7 -1.6 -0.4 -0.5 -0.6 -1.0 0.2 -0.9
Medication: Paracetamol 0.4 0.6 1.5 -1.2 0.1 -1.0 0.0 -0.4 0.4 0.7 -1.2
Headache pain in last month 0.6 1.1 3.3 -0.6 -0.2 -0.5 -1.3 -1.8 0.3 -1.6 -0.7
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 9.0 -1.1 -1.1 -3.0 -1.8 -2.0 0.5 -1.7 -2.3
Glaucoma (self-reported) 0.4 0.4 2.0 -0.2 0.5 0.4 -0.3 -0.1 -0.8 -1.4 0.4
Gout (self-reported) 0.3 0.4 1.0 -0.2 0.2 -0.6 0.8 1.0 0.7 0.7 0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.5 0.1 0.6 -1.0 0.8 -0.0 1.2 -0.0 0.2
Medication: Amlodipine 0.3 0.4 1.4 -0.2 -1.2 0.4 -0.2 -0.9 -0.5 -0.5 0.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.1 -0.8 -0.2 -0.3 0.6 0.1 -1.4 0.9 -0.5
Birth weight 0.3 0.8 2.3 -0.7 0.7 -0.8 -0.7 -0.6 1.1 -1.5 0.1
Chronic bronchitis/emphysema (mother) 2.1 2.5 7.4 0.9 -1.3 -0.6 -2.3 -2.7 0.1 -0.7 -1.9
High blood pressure (siblings) 1.1 1.6 6.4 0.3 1.0 1.3 -0.4 0.3 1.8 2.5 -0.3
Forced vital capacity (FVC), Best measure 0.0 0.2 0.4 -0.1 0.0 0.6 -0.7 0.4 -0.5 0.5 0.0
Body fat percentage 0.1 0.3 1.0 0.1 -0.9 -0.6 1.0 0.3 -0.0 0.3 -0.4
Leg fat percentage (right) 0.1 0.4 1.8 0.1 -0.4 -0.2 1.4 0.6 -0.0 0.9 -0.0
Arm fat-free mass (right) 0.3 1.4 3.0 -0.7 1.2 0.5 1.7 1.5 0.8 1.4 1.1
Exposure to tobacco smoke outside home 0.4 0.5 1.7 -1.3 -0.6 -0.5 0.5 -0.9 0.1 0.5 -0.4
Comparative body size at age 10 0.1 0.4 1.4 0.2 0.1 -1.0 -0.2 0.1 1.2 -0.7 -0.5
Number of full brothers 0.5 0.6 1.4 -1.1 -0.0 -1.2 0.3 -1.0 0.7 -0.8 -0.6
Worry too long after embarrassment 0.2 0.4 0.6 -0.8 -0.3 -0.8 0.6 -0.4 0.7 0.7 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.8 0.1 1.5 -0.1 0.6 1.0 1.7 0.1 0.9
Wheeze or whistling in the chest in last year 0.5 0.9 3.1 -0.9 -1.8 -0.7 0.1 -0.3 -0.6 1.3 -0.9
Number of children fathered 0.7 0.8 2.3 0.1 0.5 0.5 -1.1 0.4 1.5 1.5 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.4 1.5 1.4 0.1 -0.3 0.2 1.0 -0.0 0.2
Age at first live birth 0.8 1.4 4.6 0.8 1.7 2.2 -1.1 1.0 0.1 0.9 0.6
Pulse wave peak to peak time 1.2 1.4 3.8 -0.6 -1.2 -2.0 -1.1 -0.4 0.3 -1.2 -1.7
Health satisfaction 0.9 1.2 3.4 -1.8 -0.8 -0.8 -0.7 -0.6 1.4 0.6 -1.5
Shortness of breath walking on level ground 0.5 0.6 3.1 -0.5 -1.1 0.0 -0.6 -0.3 -0.0 -0.0 -1.8
Qualifications: College or University degree 0.9 2.9 6.1 1.8 1.1 2.4 1.3 2.5 -0.4 1.0 2.0
Eye problems/disorders: None of the above 1.3 1.4 7.3 2.7 0.7 1.5 -0.7 0.4 -0.8 -0.0 0.4
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.2 -0.2 0.1 -0.9 -1.1 -0.6 0.9 -0.6 -0.2
Emphysema/chronic bronchitis 0.4 0.4 1.5 -0.3 -1.0 -0.3 0.4 -0.8 -1.2 0.3 0.3
Medication for pain relief, constipation, heartburn 0.4 0.7 2.7 1.3 -0.1 -0.0 -0.7 -0.1 -0.5 -1.6 0.2
Neck or shoulder pain in last month 0.5 0.6 2.8 -0.9 0.8 0.4 0.6 0.2 -0.6 1.7 0.1
Medication: Blood pressure 1.2 2.2 6.8 0.9 0.3 2.6 0.9 1.2 -1.1 1.8 1.6
Angina (self-reported) 0.2 0.2 0.6 0.2 -0.0 0.5 -0.8 -0.5 0.1 0.6 -0.1
Migraine (self-reported) 0.7 0.9 4.0 0.3 0.9 -0.0 -1.1 -0.9 -0.1 -2.0 -0.3
Medication: Ibuprofen 0.3 0.4 1.1 0.5 0.7 -0.1 1.0 0.3 0.4 1.1 0.3
Medication: Allopurinol 0.1 0.2 0.4 0.3 -0.4 -0.6 0.2 0.6 -0.4 0.0 0.2
Medication: Omeprazole 0.8 0.9 5.7 -2.4 -0.3 -0.8 0.8 0.2 0.1 0.4 -0.2
Medication: Seretide 50 evohaler 0.5 0.5 0.9 1.0 -0.5 -0.9 -0.5 -0.8 0.3 -0.5 -0.9
Mean time to correctly identify matches 0.3 0.5 1.1 -0.8 0.2 -0.9 0.0 -0.9 0.6 -1.1 0.1
Heart disease (mother) 0.6 0.7 2.1 -1.4 -0.5 -0.3 1.2 0.7 -0.3 -0.3 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.4 0.6 0.0 -1.3 -0.8 -0.7 1.9 0.6 -0.7
Whole body fat mass 0.1 0.3 1.0 0.2 -0.4 -0.4 1.0 0.5 0.3 0.6 -0.2
Leg fat mass (right) 0.1 0.3 1.1 0.3 -0.4 -0.3 1.0 0.6 0.3 0.8 -0.2
Arm predicted mass (right) 0.4 1.8 3.6 -0.6 1.2 0.7 1.9 1.7 0.9 1.9 1.2
Pulse rate, automated reading 0.5 1.8 4.9 -0.0 2.2 0.0 1.6 1.4 1.3 1.4 0.9
Alcohol intake frequency. 0.6 1.3 3.5 -0.4 0.2 -0.7 1.9 0.1 -1.7 -1.1 1.4
Comparative height size at age 10 0.1 0.7 1.3 -1.1 0.8 1.1 -0.3 -1.1 -0.2 -0.9 -0.4
Number of full sisters 0.5 0.6 1.6 -0.1 -1.3 -0.2 -0.3 -0.9 -0.8 -1.2 -0.5
Suffer from ‘nerves’ 0.1 0.2 1.3 0.5 1.2 0.3 -0.1 0.1 0.3 0.2 0.3
Overall health rating 0.4 0.9 1.9 -0.9 -1.2 -0.1 -0.6 -0.8 0.7 1.2 -1.4
Chest pain or discomfort 0.5 0.8 1.5 1.0 -1.2 0.2 -1.1 -0.9 -0.6 -0.7 -0.9
Had major operations 0.4 0.4 1.5 0.2 -0.3 -0.4 -1.2 -0.3 -0.2 -1.0 -0.8
Age at last live birth 0.4 0.6 2.1 0.6 0.7 1.4 -1.1 0.3 0.0 0.2 -0.2
Family relationship satisfaction 1.1 1.4 2.3 -1.1 -1.2 -1.5 -0.7 -1.3 0.3 -1.5 -1.2
Leg pain on walking 0.2 0.3 1.7 -0.2 -0.1 -0.2 0.1 -0.4 1.3 -0.2 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 4.0 -1.8 -1.2 -2.0 1.5 0.1 -0.6 0.4 -0.2
Commuting to job workplace: Car/motor vehicle 1.5 1.7 5.6 2.4 -1.4 0.8 -0.2 0.0 -2.3 0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.8 0.8 0.5 0.8 -0.8 -0.3 -0.5 0.1 -0.9
Medication: Aspirin 1.5 2.0 7.0 -1.1 0.3 1.7 1.5 0.8 0.3 2.6 1.5
Supplements: Vitamin C 0.2 0.2 0.6 0.5 0.5 0.5 0.6 0.4 -0.0 0.7 0.2
Knee pain experienced in last month 0.4 0.6 2.0 0.6 0.1 0.6 0.7 1.1 -0.3 1.4 0.2
Hypertension (Self-reported) 0.4 1.1 2.9 1.4 0.8 1.7 -1.0 0.2 -1.0 1.2 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 0.1 0.4 -0.5 -0.9 -0.0 1.2 -0.2 -0.3
Illnesses of father: Heart disease 1.0 1.3 3.1 -1.5 0.4 1.4 1.8 1.2 0.0 0.5 1.2
Illnesses of siblings: Diabetes 1.3 1.6 6.7 -0.7 -0.9 -0.1 1.5 0.0 -2.6 -1.3 0.7
Smoking status: Previous 0.2 0.3 1.0 -0.6 -0.5 0.1 -0.5 0.3 0.3 1.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.9 0.4 2.0 1.4 0.5 1.4 -0.0 0.7 1.4
Whole body fat-free mass 0.2 1.2 2.2 -0.1 1.2 0.7 1.4 1.5 0.8 1.3 0.9
Leg fat-free mass (right) 0.2 1.1 2.4 -0.3 0.9 0.6 1.5 1.6 0.5 1.2 0.8
Arm fat percentage (left) 0.1 0.5 1.8 -0.2 -1.3 -0.8 1.1 0.2 -0.3 -0.1 -0.5
Average weekly red wine intake 0.2 0.3 0.7 -0.8 0.4 -0.7 0.3 0.0 0.9 0.4 -0.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.5 -0.9 -1.2 -0.9 1.1 -0.3 -0.4 0.3 -0.1
Mood swings 2.2 4.0 7.4 -1.8 -0.8 -2.5 -2.2 -2.3 0.9 -1.8 -2.7
Loneliness, isolation 0.4 0.6 2.5 -1.0 -0.3 -1.6 -0.1 -0.6 0.6 -0.6 -0.3
Long-standing illness, disability or infirmity 0.3 0.4 1.3 -1.1 0.3 -0.6 0.0 -0.2 -0.3 1.0 -0.6
Ever had bowel cancer screening 0.4 0.5 1.3 -1.1 0.2 0.4 -0.1 0.2 1.1 1.1 -0.0
Diabetes diagnosed by doctor 0.1 0.2 1.4 0.3 -0.4 0.3 0.1 -0.1 -1.2 -0.4 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 -0.4 -0.0 0.5 -1.3 -0.8 0.4 0.2 -0.4
Friendships satisfaction 0.3 0.4 1.6 -0.4 0.0 -1.2 0.6 0.4 0.6 -0.8 0.0
Qualifications: nursing, teaching 0.4 0.6 1.2 1.0 -0.3 1.0 0.5 1.1 -0.6 1.0 0.5
Commuting to job workplace: Walk 1.9 2.1 4.7 -1.6 0.6 -1.4 -1.2 -1.6 1.3 -2.2 -1.1
Eye problems/disorders: Cataract 0.6 0.7 2.9 -1.7 -1.0 -0.5 0.2 -0.4 0.5 0.9 -0.4
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 5.0 -1.6 -1.0 0.2 2.2 1.4 -1.2 1.3 0.9
Medication for cholesterol 0.2 0.3 0.9 -0.5 0.8 0.2 0.2 0.6 0.3 0.5 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.4 -0.8 -0.7 -0.9 0.0 -0.1 1.2 0.8 -0.5
Back pain experienced in last month 1.1 1.5 2.8 -1.4 -1.3 -1.5 -0.6 -1.7 -0.1 -0.9 -1.6
Mineral and other dietary supplements 2.2 2.9 5.7 2.3 -2.1 0.3 -0.9 -1.3 -2.1 -2.4 -0.9
Breast cancer (self-reported) 0.1 0.1 0.6 -0.1 0.3 -0.2 0.2 0.5 0.4 0.8 0.3
Asthma (self-reported) 0.4 0.8 2.1 -0.4 -0.4 -0.9 -1.2 -0.7 -0.4 0.8 -1.4
Osteoporosis (self-reported) 0.5 0.6 1.9 -0.9 -0.4 -0.9 -0.5 -1.4 0.2 -0.3 -0.8
Osteoarthritis (self-reported) 1.5 2.0 4.5 -1.0 -0.4 -2.1 -1.1 -2.0 1.1 -1.3 -1.4
Medication: Aspirin 1.1 1.4 4.6 -0.9 0.2 1.5 1.4 0.5 -0.1 2.1 1.2
Medication: Gliclazide 0.2 0.2 0.7 0.2 -0.4 0.2 -0.2 -0.0 -0.7 -0.9 -0.3
Illnesses of father: None of the above (group 1) 0.7 0.9 2.2 1.5 -0.3 -1.4 -0.5 0.0 0.4 1.2 -0.8
Smoking status: Current 0.2 0.4 1.1 -0.2 -0.3 0.8 0.8 0.1 -1.1 0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.2 -0.7 0.3 -0.5 -0.3 -0.3 1.1 0.7 -0.6
Whole body water mass 0.2 1.1 2.1 -0.2 1.1 0.7 1.4 1.5 0.7 1.2 0.8
Leg predicted mass (right) 0.2 1.2 2.6 -0.3 1.0 0.8 1.6 1.6 0.6 1.3 1.0
Arm fat mass (left) 0.1 0.5 2.3 -0.4 -0.6 -0.4 1.5 0.8 -0.2 0.5 0.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.6 -0.8 0.3 -0.4 -0.1 -0.1 0.2 0.5 -0.1
Average weekly champagne plus white wine intake 0.3 0.4 1.4 0.2 -0.4 0.6 -0.5 -0.4 -1.2 -1.0 0.2
Miserableness 0.3 0.5 2.3 -1.5 -0.2 -0.8 0.0 -0.7 0.8 -0.3 -0.4
Guilty feelings 0.9 1.3 4.7 -0.5 1.0 -0.4 -1.1 -1.3 2.2 0.4 -1.0
Wears glasses or contact lenses 0.9 1.1 3.6 0.9 -1.9 -0.3 -0.9 -0.3 -1.0 -0.7 -1.3
Ever taken oral contraceptive pill 5.6 6.2 12.9 0.2 2.2 2.1 3.6 3.4 -0.3 1.9 3.5
Hearing aid user 1.4 1.6 4.2 -1.1 -0.9 -2.0 -1.2 -1.5 1.1 -0.1 -1.3
Mother’s age at death 0.5 0.6 1.6 -0.3 -0.7 -0.8 -0.5 -0.1 0.7 -1.2 -1.2
Financial situation satisfaction 1.6 2.0 3.5 -1.6 -1.9 -1.9 -0.1 -1.7 0.0 -0.9 -1.6
Tinnitus: Yes, now most or all of the time 0.9 1.0 3.7 0.1 -0.7 1.0 1.4 0.9 -1.9 0.3 0.4
Commuting to job workplace: Public transport 0.2 0.3 0.7 -0.6 0.8 -0.0 -0.0 0.3 0.7 -0.7 0.1
Eye problems/disorders: Glaucoma 0.5 0.6 1.6 -0.8 -0.4 -1.2 -0.3 -0.8 0.3 -1.3 -0.6
Medication: Blood pressure 0.1 0.3 1.1 -0.3 0.1 0.3 -0.8 -0.4 -0.1 0.4 -1.0
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 0.8 -0.5 -0.4 -0.6 -0.3 0.2 -0.5 -0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.8 -1.4 1.4 -0.6 -0.5 0.7 1.5 1.7 0.1
High cholesterol (Self-reported) 0.7 1.2 2.1 0.5 0.3 0.9 1.4 1.2 1.1 1.4 1.4
Medication: Bendroflumethiazide 0.4 0.6 1.6 -0.1 1.3 0.7 1.2 -0.0 0.2 0.5 1.0
Medication: Paracetamol 0.4 0.7 1.7 -0.9 0.2 -1.1 -0.1 -0.6 0.8 0.8 -1.3
Medication: Lisinopril 0.6 0.8 2.5 -0.3 -0.1 1.2 0.2 1.3 -1.6 0.9 0.3
Medication: Atorvastatin 1.4 1.7 3.8 -0.3 0.7 1.9 1.8 1.7 -0.0 1.2 1.4
Illnesses of father: High blood pressure 0.4 0.4 0.9 -0.6 -1.0 -0.1 -0.7 -0.3 -0.5 -0.8 -0.9
Alcohol drinker status: Never 0.3 0.3 0.8 -0.4 -0.0 -0.9 -0.2 -0.7 -0.5 -0.8 -0.4
Ever smoked 0.4 0.7 2.6 -1.2 -0.2 0.5 0.3 0.3 0.1 1.6 1.1
Basal metabolic rate 0.2 1.1 2.4 0.0 0.9 0.7 1.6 1.5 0.5 1.2 0.8
Leg fat percentage (left) 0.1 0.5 1.8 -0.2 -0.5 -0.3 1.3 0.9 0.1 1.0 0.0
Arm fat-free mass (left) 0.3 1.6 3.6 -0.4 1.2 0.6 1.9 1.6 0.6 1.6 1.1
Number of operations (self-reported) 0.7 1.0 4.7 -2.2 -0.3 -0.2 0.2 0.1 -1.3 -1.0 -0.7
Average weekly beer plus cider intake 0.8 1.1 2.2 -0.6 1.4 0.9 1.5 1.0 1.0 1.1 0.8
Irritability 1.6 2.7 5.3 -1.8 -0.9 -2.1 -1.4 -2.3 0.5 -1.5 -1.7
Risk taking 0.8 1.1 2.4 0.8 -0.7 1.0 1.6 1.1 -0.9 0.9 1.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.1 -0.2 0.5 0.5 -1.0 -0.4 1.4 -0.4 -0.1
Fractured/broken bones in last 5 years 1.0 1.3 5.5 -0.6 -1.1 -0.0 1.4 0.8 -2.3 0.4 0.5
Age started oral contraceptive pill 1.9 2.4 10.8 -3.3 1.2 -0.9 0.5 0.5 2.3 -0.1 0.4
Diastolic blood pressure, automated reading 2.1 6.6 18.4 0.6 3.2 1.4 1.6 3.2 2.7 4.3 1.3
Ever depressed for a whole week 0.6 0.7 2.2 -1.2 -1.0 -1.5 0.6 -0.3 -0.2 -0.6 0.1
Unable to work because of sickness or disability 0.9 1.2 2.8 -1.7 -1.3 -1.4 0.1 -1.6 0.1 -0.7 -0.3
Commuting to job workplace: Cycle 0.3 0.3 1.4 -0.7 0.3 0.5 0.6 0.3 -1.2 -0.4 0.1
Myopia 0.6 0.9 3.3 0.2 -0.1 1.1 1.0 1.0 -1.8 -0.3 0.9
Vascular/heart problems diagnosed by doctor 0.7 1.9 6.4 -1.6 -1.0 -2.5 0.3 -0.7 1.0 -1.8 -0.5
Cholesterol lowering medication 0.2 0.4 1.3 -0.5 -1.1 -0.0 0.9 -0.2 -0.3 0.6 0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.1 -1.8 -0.4 -0.6 0.3 -0.1 -0.4 -0.3 -0.4
Pain experienced in last month 0.2 0.3 0.7 0.7 -0.6 -0.8 -0.1 -0.5 0.4 -0.1 -0.3
Supplements: Calcium 1.0 1.1 2.0 -1.2 1.1 0.5 1.4 0.5 0.9 1.2 1.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.8 1.0 1.0 1.3 -0.7 0.4 0.5 1.1 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.3 1.8 -0.2 1.0 -1.1 -0.1 -0.1 0.6 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.0 -0.8 -2.0 -0.7 -0.9 -1.3 -1.4 -0.2 -1.2
Heart disease (siblings) 0.7 0.9 3.4 0.1 0.3 1.8 0.8 0.6 -0.4 -0.5 1.4
Alcohol drinker status: Previous 2.0 2.2 5.7 -0.9 2.0 0.2 1.9 1.8 -0.4 0.1 2.4
Pack years of smoking 0.1 0.1 0.2 0.4 -0.3 -0.0 -0.4 -0.1 -0.3 0.4 -0.5
Impedance of whole body 0.4 2.0 4.6 0.7 -0.8 -0.8 -2.1 -1.8 -0.5 -2.0 -1.5
Leg fat mass (left) 0.1 0.3 1.2 0.1 -0.3 -0.3 1.1 0.7 0.3 0.8 -0.1
Arm predicted mass (left) 0.3 1.8 4.5 -0.4 1.1 0.5 2.1 2.0 0.2 1.6 1.2