Hub : Genes

ALOX15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.1339	0.0192	0.0e+00	0.179	0.149	0.170	0.177	0.176	1.6e-55	1.0e-45	2.1e-52	8.7e-55	1.8e-54
2	ROSMAP	Brain Pre-frontal Cortex	0.1849	0.0319	3.3e-16	0.211	0.159	0.209	0.206	0.219	1.3e-26	6.5e-20	2.2e-26	7.0e-26	1.3e-27
3	TCGA	Bladder Urothelial Carcinoma	0.0570	0.0270	4.1e-03	-0.002	0.024	0.005	NA	0.001	5.0e-01	3.5e-03	1.0e-01	NA	2.3e-01
4	TCGA	Brain Lower Grade Glioma	0.0965	0.0321	1.2e-06	0.054	0.049	0.051	NA	0.051	7.9e-07	2.7e-06	1.9e-06	NA	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.2	0.1	0.0	0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	1.0	1.0	-0.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	-1.3	0.4	-0.4	0.2
Depression (Nagel 2018)	2.2	3.3	5.0	-2.2	2.0	-1.1	1.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.9	-0.3	-0.8	-0.2
Neuroticism (Nagel 2018)	0.1	0.1	0.4	-0.7	-0.1	0.1	-0.3
Schizophrenia (2018)	0.2	0.4	1.5	1.2	-0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	0.0	0.0	0.0
Worry (Nagel 2018)	0.1	0.1	0.3	-0.6	-0.1	0.3	-0.2
Alzheimer’s Disease (in mother)	1.2	1.4	1.7	1.3	-1.3	0.8	-1.3
Alzheimer’s Disease (in father)	0.2	0.3	0.5	0.7	-0.3	-0.0	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.3	2.0	1.3	-1.2	0.3	-1.4
Crohns Disease (2017)	0.7	1.4	2.7	-1.6	1.1	-0.9	1.1
Irritable Bowel Disease (IBD)	3.5	8.2	8.9	-2.9	3.0	-2.9	2.7
Ulcerative Colitis (UC)	4.8	9.1	11.3	-2.6	3.4	-2.9	3.1
Major Depression (MDD)	0.5	0.6	1.3	1.0	-1.1	0.0	0.0
Reaction Time	0.4	0.8	1.4	1.0	-1.0	-0.1	-1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.1	-0.3	1.0	-1.5	1.1
Breast Cancer	0.1	0.3	0.5	0.7	-0.4	0.6	-0.5
Ovarian Cancer	1.2	1.6	2.1	1.4	-1.1	1.4	-1.0
Prostate Cancer	0.5	0.7	2.1	0.1	0.6	-1.4	0.6
Age at First Birth	0.6	0.9	1.4	1.0	-1.2	0.2	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.5	0.7	0.1	0.8
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.3	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.4	3.1	-1.8	1.6	0.0	0.0
Mean Putamen Volume	1.3	1.5	4.1	0.7	-0.8	2.0	-0.9
Fasting Glucose	0.7	0.8	2.7	0.7	-1.6	0.2	-0.2
HbA1C	0.1	0.1	0.2	-0.4	0.1	-0.2	0.0
HDL Cholesterol	0.1	0.1	0.3	-0.2	0.0	0.6	-0.1
LDL Cholesterol	2.5	3.9	7.0	-2.6	2.0	-0.8	2.0
Lupus	2.1	3.2	4.2	-1.9	2.0	-1.1	2.0
Neuroticism (2016)	1.9	2.7	3.8	-2.0	1.7	-0.9	1.8
Primary Biliary Cirrhosis	0.4	0.6	1.7	-0.4	0.4	-1.3	0.5
Rheumatoid Arthritis	2.4	3.3	7.7	-1.3	1.5	-2.8	1.2
Schizophrenia (2014)	0.1	0.2	0.6	0.7	-0.3	0.0	0.0
Triglycerides	0.2	0.3	0.8	-0.4	0.5	0.1	0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	-0.5	0.0	0.0
Ulcerative Colitis	3.1	4.5	11.1	-2.6	3.3	0.0	0.0
Blood Eosinophil Count	11.8	90.7	130.0	11.4	-9.2	9.1	-8.1
Blood Platelet Count	0.3	3.3	4.0	-1.9	2.0	-1.1	2.0
Blood Red Count	0.1	0.7	1.5	1.2	0.3	-1.1	0.1
Blood White Count	3.3	24.8	37.6	-4.7	5.6	-3.0	6.1
Heel T-Score	0.5	3.9	5.7	-2.1	2.4	0.1	2.4
BMI	1.0	6.0	7.9	-1.8	2.8	-2.3	2.8
Height	0.1	1.2	1.8	-0.9	1.2	1.3	0.9
Waist Hip Ratio (WHR)	0.2	0.9	3.1	0.3	0.3	-1.8	0.5
Systolic Blood Pressure	0.6	2.9	4.4	-2.1	1.9	-0.4	1.9
Smoking Status	0.2	0.5	1.2	-0.3	0.7	0.2	1.1
Allergy or Eczema	0.1	0.2	0.4	0.4	0.5	-0.3	0.6
Cardiovascular Disease	0.0	0.1	0.3	0.5	-0.3	-0.4	0.2
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.8	0.6	-0.5	0.6
Respiratory disease	0.6	1.4	2.2	-1.5	1.2	0.7	1.2
Type 2 Diabetes (T2D) (2018)	2.0	3.8	4.5	1.9	-2.1	1.6	-2.1
Lung FEV1/FVC ratio	0.1	0.4	1.2	-0.3	0.6	0.1	1.1
Lung FVC	0.4	2.2	4.8	-2.2	1.5	0.7	1.2
Neuroticism	0.1	0.3	0.9	-1.0	0.5	0.1	0.4
Chronotype (morning person)	0.9	2.0	4.6	0.8	-1.3	2.1	-1.1
Hair Pigment	0.0	0.7	1.3	-0.5	0.9	1.1	0.7
Tanning	0.0	0.2	0.7	-0.3	-0.3	0.8	-0.0
Hand grip strength (left)	0.5	1.3	2.1	-1.5	1.2	0.9	0.9
Number of treatments/medications taken	0.8	1.4	1.9	-0.7	1.2	-1.4	1.4
Average weekly spirits intake	0.6	0.7	1.3	0.8	-0.8	1.1	-0.5
Sensitivity / hurt feelings	0.1	0.1	0.4	0.2	0.1	-0.6	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-0.9	0.8	-0.2	0.7
Hearing difficulty/problems: Yes	2.0	3.1	4.4	-1.7	2.0	-1.2	2.1
Relative age of first facial hair	0.2	0.4	0.8	-0.3	0.6	-0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	-0.3	-0.0	-0.7	-0.1
Ever used hormone-replacement therapy (HRT)	1.9	2.4	3.4	-1.6	1.9	-0.4	1.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.4	0.5	0.1	0.2
Systolic blood pressure, automated reading	2.1	6.1	8.4	-2.5	2.9	-1.4	2.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.0	-1.2	1.3	-0.7	1.4
Angina	0.4	0.6	2.0	-0.4	-0.1	-1.4	-0.2
Medication for hormone replacement therapy	0.3	0.3	0.6	0.8	0.3	-0.5	0.5
Vitamin and mineral supplements	0.7	1.0	1.5	1.1	-1.2	-0.1	-1.1
Supplements: Zinc	0.1	0.1	0.2	-0.3	0.3	0.1	0.4
Medication: Co-codamol	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.3
Medication: Metformin	1.2	1.7	2.6	1.6	-1.2	1.2	-1.2
Diabetes (father)	3.3	4.1	8.4	2.0	-1.5	2.9	-1.3
Diabetes (mother)	0.7	0.9	1.3	1.0	-1.1	-0.1	-1.1
Severe depression (siblings)	2.9	3.2	4.6	1.7	-1.7	2.1	-1.6
Pack years adult smoking proportion	0.3	0.4	1.5	0.5	-0.1	-1.2	0.1
Impedance of leg (right)	0.4	1.9	3.1	1.8	-1.6	0.8	-1.2
Leg fat-free mass (left)	0.3	1.6	2.7	-1.2	1.6	-0.8	1.3
Trunk fat percentage	0.2	0.6	1.0	-0.1	1.0	-0.7	1.0
Hand grip strength (right)	0.9	2.3	4.2	-2.0	1.5	1.1	1.3
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.4	0.2	-1.1	0.0
Current tobacco smoking	0.5	0.8	2.2	0.9	-0.3	1.5	0.1
Average weekly fortified wine intake	0.5	0.6	2.2	0.1	0.3	1.5	0.4
Maternal smoking around birth	1.3	1.9	2.4	-1.2	1.3	-1.6	1.4
Fed-up feelings	0.5	1.0	2.2	-1.5	0.8	-1.0	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.6	-1.1	1.0	-1.3	0.9
Relative age voice broke	0.3	0.5	0.8	-0.4	0.8	-0.6	0.9
Taking other prescription medications	0.0	0.0	0.1	-0.2	0.0	-0.2	0.3
Age when periods started (menarche)	1.6	3.8	5.2	-2.3	2.1	-1.1	2.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.8	-0.8	0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	4.0	-1.4	1.8	-1.0	2.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	0.2	0.5	0.3
Qualifications: CSEs or equivalent	0.8	1.0	2.7	-0.9	0.6	-1.6	0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.4	-0.7	-0.5	1.5	-0.6
High blood pressure	0.2	0.6	1.0	0.2	0.7	-1.0	1.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	-0.5	0.6	-1.2	0.5
Multivitamins +/- minerals	0.7	0.9	1.4	-1.2	1.1	-0.3	0.9
Stomach or abdominal pain in last month	0.6	0.7	0.9	0.9	-0.8	0.7	-0.9
Supplements: Glucosamine	0.1	0.2	0.6	-0.1	-0.0	-0.8	-0.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	3.2	-1.6	1.8	-1.6	1.6
Medication: Atenolol	0.6	0.8	1.2	-0.9	1.0	0.1	1.1
Medication: Levothyroxine sodium	0.5	0.8	2.0	-0.5	0.7	-1.4	0.8
Sitting height	0.6	4.4	7.8	-2.8	2.3	-0.6	2.1
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	-0.4	-0.6	0.8	-0.6
High blood pressure (mother)	2.9	4.1	5.2	2.3	-2.1	1.2	-2.3
Body mass index (BMI)	0.9	3.7	5.3	-1.4	2.3	-1.7	2.2
Impedance of leg (left)	0.3	1.7	2.3	1.5	-1.5	1.0	-1.1
Leg predicted mass (left)	0.3	1.7	2.8	-1.3	1.7	-0.8	1.4
Trunk fat mass	0.3	1.4	2.4	-0.6	1.5	-0.9	1.4
Waist circumference	0.6	2.3	2.9	-0.9	1.7	-1.7	1.6
Number of incorrect matches in round	0.8	1.4	1.9	-1.3	1.4	0.3	1.3
Past tobacco smoking	0.6	1.1	1.4	1.0	-1.0	1.0	-1.2
Alcohol usually taken with meals	0.0	0.1	0.1	0.2	0.2	-0.2	0.3
Nervous feelings	0.3	0.5	1.0	0.3	-0.8	0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.5	-0.8	0.9	-1.2	1.1
Hearing difficulty/problems with background noise	3.9	6.2	8.5	-2.6	2.2	-2.9	2.1
Hair/balding pattern: Pattern 2	3.1	3.9	4.6	1.7	-2.1	2.0	-2.1
Had menopause	0.2	0.2	0.3	-0.6	0.6	-0.2	0.3
Had other major operations	0.3	0.3	0.6	-0.8	0.4	-0.5	0.5
Forced vital capacity (FVC)	0.1	0.5	1.3	-1.1	0.6	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	4.5	-1.7	2.0	-1.2	2.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.1	-0.5	0.2	-0.6
Qualifications: None of the above	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.4
Financial difficulties in last 2 years	1.6	2.2	3.5	-1.4	1.8	-0.3	1.9
Mouth/teeth dental problems	2.0	3.1	4.2	1.7	-2.0	1.3	-1.8
Heart attack	0.1	0.1	0.1	-0.3	0.1	-0.2	0.3
Allergy	0.4	0.8	2.0	0.6	-0.7	1.4	-0.7
Pain all over the body in last month	0.1	0.1	0.3	0.5	-0.1	0.4	-0.0
Diabetes (self-reported)	0.7	1.1	1.5	1.2	-1.2	0.2	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.7	0.9	-1.3	-0.2	-1.2
Medication: Ramipril	1.1	1.4	2.5	1.6	-1.5	-0.1	-1.0
Medication: Simvastatin	0.1	0.2	0.3	0.6	-0.5	-0.1	-0.3
Fluid intelligence score	1.7	3.5	5.0	-1.2	1.9	-2.2	2.0
Illnesses of siblings	1.1	1.6	2.3	1.5	-1.4	-0.1	-1.4
Neuroticism score	0.1	0.2	0.7	-0.8	0.2	-0.5	0.1
Weight	0.6	2.9	4.8	-1.4	2.2	-1.1	1.9
Impedance of arm (right)	1.3	6.2	8.4	2.3	-2.9	1.8	-2.8
Arm fat percentage (right)	0.2	0.7	1.3	-0.4	1.1	-0.5	1.0
Trunk fat-free mass	0.5	3.1	5.0	-1.9	2.2	-0.5	1.9
Hip circumference	0.1	0.5	1.2	-0.4	1.1	-0.1	0.9
Time employed in main current job	0.2	0.3	0.7	0.2	-0.4	0.8	-0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.9	0.2	-0.2	-1.7	-0.2
Father’s age at death	0.1	0.1	0.2	-0.0	-0.2	-0.2	-0.4
Worrier / anxious feelings	0.2	0.3	0.6	-0.5	-0.4	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.5	-0.7	0.3	-0.5
Falls in the last year	0.9	1.2	2.2	0.5	-1.2	0.9	-1.5
Hair/balding pattern: Pattern 3	1.4	2.2	7.5	-0.7	0.8	-2.7	0.4
Number of live births	0.5	0.7	1.4	-0.9	0.6	-1.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.7	-0.8	0.8	-0.2	0.7
Pulse rate	0.4	0.6	1.3	-0.2	1.1	-0.0	1.2
Happiness	3.0	3.7	5.9	1.7	-2.3	0.7	-2.4
Noisy workplace	1.3	1.6	3.0	-1.1	1.1	-1.7	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.4	1.0	-0.4	-1.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.4	-0.0	-0.0	-0.2
Mouth/teeth dental problems: Dentures	1.8	3.0	5.9	-2.4	1.9	-0.6	1.5
Asthma	0.3	0.6	1.1	-0.9	0.8	0.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	4.3	-2.0	2.1	-1.7	1.8
Medication: Cholesterol lowering	0.2	0.3	0.8	0.5	-0.1	-0.9	0.3
Depression (self-reported)	2.4	2.8	4.3	1.4	-2.0	1.0	-2.1
Medication: Lansoprazole	0.6	0.7	1.6	1.2	-0.8	-0.6	-0.6
Prospective memory result	2.6	3.2	3.5	1.9	-1.8	1.9	-1.6
Lung cancer (father)	0.4	0.4	1.0	-0.6	0.6	0.4	1.0
Illnesses of mother	2.6	3.3	5.2	-2.3	1.8	-1.5	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.0	0.7	-0.5	0.8
Impedance of arm (left)	1.6	7.3	10.3	2.9	-3.2	1.4	-3.0
Arm fat mass (right)	0.4	1.7	2.9	-0.9	1.7	-0.8	1.5
Trunk predicted mass	0.5	2.8	4.4	-1.9	2.1	-0.4	1.8
Standing height	0.0	0.4	1.5	0.0	-0.1	1.2	-0.4
Length of working week for main job	3.2	3.5	5.0	-2.0	2.2	-0.0	2.2
Exposure to tobacco smoke at home	1.1	1.2	4.6	0.2	-0.4	2.1	-0.2
Breastfed as a baby	0.6	0.8	1.6	-0.8	0.7	-1.3	0.5
Tense / ‘highly strung’	0.0	0.1	0.1	-0.3	0.1	0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	4.9	1.2	-1.5	2.2	-1.6
Hair/balding pattern: Pattern 4	1.1	2.8	4.5	-1.3	1.8	-1.2	2.1
Birth weight of first child	0.5	0.8	1.2	0.5	-1.0	1.1	-1.0
Peak expiratory flow (PEF)	0.9	2.1	3.6	-1.1	1.8	-0.7	1.9
Pulse wave reflection index	0.3	0.3	0.5	-0.4	0.5	-0.7	0.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.2	1.0	-1.0	-0.2	-1.1
Loud music exposure frequency	0.3	0.3	0.5	-0.5	0.5	-0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.0	0.3	-0.4	1.0	-0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.2	-0.4	1.0	-1.8	0.8
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.0	0.3	-0.1	0.2
Medication: Paracetamol	1.8	3.0	4.5	-2.1	1.7	-1.3	1.7
Headache pain in last month	1.3	2.3	3.4	1.9	-1.7	0.1	-1.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	-0.8	-0.0	1.5	-0.3
Glaucoma (self-reported)	2.8	3.3	4.7	2.2	-1.7	1.7	-1.7
Gout (self-reported)	0.5	0.7	1.3	-1.1	0.8	-0.1	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	-0.7	0.6	-0.5	0.6
Medication: Amlodipine	0.5	0.7	0.8	0.8	-0.9	0.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.5	-1.2	0.9	-0.4	1.0
Birth weight	2.8	6.0	10.6	1.3	-2.3	3.3	-2.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.1	-0.2	-0.7	0.0
High blood pressure (siblings)	5.5	8.0	10.8	-3.3	3.3	-1.2	3.0
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	-0.3	-0.1	-0.0	-0.3
Body fat percentage	0.3	1.1	1.8	-0.4	1.4	-0.9	1.3
Leg fat percentage (right)	1.0	3.6	5.4	-1.1	2.3	-1.6	2.3
Arm fat-free mass (right)	0.8	3.9	6.4	-2.0	2.5	-0.7	2.2
Exposure to tobacco smoke outside home	2.0	2.7	5.0	-1.4	1.4	-2.2	1.3
Comparative body size at age 10	0.1	0.2	0.3	-0.6	0.6	0.0	0.2
Number of full brothers	0.0	0.1	0.2	-0.2	-0.1	0.4	-0.0
Worry too long after embarrassment	0.7	1.2	1.6	-1.2	1.2	-0.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.3	-0.1	0.8	-0.5
Wheeze or whistling in the chest in last year	1.1	2.0	3.6	-1.1	1.5	-1.0	1.9
Number of children fathered	3.5	4.0	4.8	-2.0	1.9	-2.2	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.1	0.1	-0.6	0.0
Age at first live birth	0.1	0.2	0.7	-0.1	-0.1	-0.8	-0.3
Pulse wave peak to peak time	0.2	0.2	0.4	-0.1	-0.5	0.4	-0.7
Health satisfaction	1.2	1.6	2.9	-1.7	1.0	-1.1	1.0
Shortness of breath walking on level ground	0.4	0.5	1.0	-1.0	0.4	-1.0	0.2
Qualifications: College or University degree	0.0	0.1	0.4	0.6	-0.1	-0.1	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.1	-0.1	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.5	0.4	-0.2	0.3
Medication for pain relief, constipation, heartburn	2.2	3.7	4.9	2.2	-2.0	0.9	-2.2
Neck or shoulder pain in last month	3.4	4.8	6.4	-2.5	2.1	-2.1	2.0
Medication: Blood pressure	0.2	0.3	0.3	0.6	0.4	-0.5	0.6
Angina (self-reported)	0.5	0.7	2.6	-0.3	-0.0	-1.6	-0.1
Migraine (self-reported)	2.3	2.8	5.9	1.2	-2.0	0.0	-2.4
Medication: Ibuprofen	2.9	3.4	3.8	-1.7	2.0	-1.9	1.8
Medication: Allopurinol	0.2	0.3	1.0	-0.2	-0.3	1.0	-0.2
Medication: Omeprazole	0.3	0.4	0.9	-0.4	0.7	0.3	0.9
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.6	0.1	0.4	-0.3
Mean time to correctly identify matches	0.1	0.3	0.5	0.3	-0.4	-0.5	-0.7
Heart disease (mother)	0.5	0.6	0.9	1.0	-0.5	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	3.6	-1.9	1.4	-1.5	1.5
Whole body fat mass	0.5	2.0	3.3	-0.9	1.8	-1.1	1.7
Leg fat mass (right)	0.9	3.5	5.4	-1.2	2.3	-1.6	2.2
Arm predicted mass (right)	1.1	5.7	8.9	-2.4	3.0	-1.0	2.7
Pulse rate, automated reading	0.4	1.2	2.4	-0.6	1.4	0.3	1.6
Alcohol intake frequency.	0.7	1.5	2.2	1.2	-1.4	0.7	-1.5
Comparative height size at age 10	0.3	1.4	3.3	1.1	-0.8	1.8	-0.7
Number of full sisters	1.4	1.6	4.3	0.9	-0.8	2.1	-0.9
Suffer from ‘nerves’	0.0	0.0	0.0	-0.0	0.1	-0.2	0.1
Overall health rating	0.9	2.0	5.0	-0.7	1.0	-2.2	1.2
Chest pain or discomfort	1.1	1.6	3.2	1.8	-1.3	0.2	-1.2
Had major operations	0.4	0.5	1.0	0.5	-0.8	0.4	-1.0
Age at last live birth	0.3	0.4	1.3	0.1	-0.2	-1.1	-0.4
Family relationship satisfaction	0.2	0.3	0.4	0.4	-0.5	0.6	-0.6
Leg pain on walking	0.2	0.2	0.8	-0.4	0.1	-0.9	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.9	-1.0	1.4	-0.8	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.9	-0.3	0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.6	-0.0	-0.3	0.1
Medication: Aspirin	1.1	1.4	2.9	-0.9	1.3	-0.6	1.7
Supplements: Vitamin C	0.5	0.6	1.3	-0.4	0.8	0.6	1.1
Knee pain experienced in last month	1.3	2.0	2.6	-1.3	1.4	-1.6	1.4
Hypertension (Self-reported)	0.1	0.4	0.6	0.4	0.4	-0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	0.7	0.1	0.1	-0.3
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.6	0.6	-0.8	0.4
Illnesses of siblings: Diabetes	2.2	2.7	5.2	1.3	-1.4	2.3	-1.4
Smoking status: Previous	0.5	0.8	1.5	-1.0	0.6	-1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.2	-0.8	0.6	-0.7
Whole body fat-free mass	0.5	2.8	4.6	-1.8	2.1	-0.6	1.8
Leg fat-free mass (right)	0.4	1.9	3.1	-1.4	1.8	-0.7	1.4
Arm fat percentage (left)	0.1	0.6	0.9	-0.2	1.0	-0.8	0.9
Average weekly red wine intake	0.1	0.2	0.6	-0.3	0.4	-0.0	0.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	-0.9	1.0	1.4	0.8
Mood swings	0.2	0.4	0.6	-0.6	-0.5	0.5	-0.8
Loneliness, isolation	0.2	0.3	1.0	-1.0	0.4	-0.4	0.1
Long-standing illness, disability or infirmity	1.0	1.5	3.3	-1.2	0.7	-1.8	0.8
Ever had bowel cancer screening	0.8	1.0	1.3	-1.1	1.1	-0.4	1.1
Diabetes diagnosed by doctor	0.4	0.6	1.0	1.0	-0.9	0.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.7	0.1	-0.1	-1.3	0.1
Friendships satisfaction	0.2	0.3	0.3	-0.4	-0.5	-0.6	-0.5
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.3	1.0	0.1	1.1
Commuting to job workplace: Walk	2.6	2.8	3.9	1.8	-1.8	1.0	-2.0
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.5	0.8	0.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.2	-1.2	1.4	-0.5	1.5
Medication for cholesterol	0.1	0.1	0.2	-0.4	0.3	0.5	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	4.5	-1.4	1.5	-2.1	1.7
Back pain experienced in last month	0.2	0.3	0.8	-0.9	0.3	-0.7	0.1
Mineral and other dietary supplements	4.5	6.0	8.6	2.6	-2.9	0.9	-2.7
Breast cancer (self-reported)	0.1	0.1	0.2	-0.1	0.3	-0.0	0.5
Asthma (self-reported)	0.3	0.6	0.9	-0.9	0.8	0.4	1.0
Osteoporosis (self-reported)	0.7	0.8	2.6	-0.9	0.1	-1.6	-0.2
Osteoarthritis (self-reported)	0.3	0.4	1.3	-0.5	0.1	-1.1	-0.2
Medication: Aspirin	0.5	0.7	1.4	-0.4	0.8	-0.6	1.2
Medication: Gliclazide	0.6	0.7	1.2	0.7	-1.1	0.2	-1.1
Illnesses of father: None of the above (group 1)	2.0	2.4	3.2	-1.7	1.4	-1.3	1.8
Smoking status: Current	0.4	0.6	1.9	0.5	0.0	1.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.2	-1.0	0.8	-1.1	0.8
Whole body water mass	0.5	2.6	4.3	-1.7	2.1	-0.6	1.7
Leg predicted mass (right)	0.4	1.9	3.1	-1.5	1.8	-0.6	1.4
Arm fat mass (left)	0.3	1.4	2.5	-0.7	1.6	-0.8	1.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.2	0.3	-1.2	0.4
Average weekly champagne plus white wine intake	1.0	1.4	2.0	1.4	-1.3	0.5	-1.4
Miserableness	0.0	0.1	0.1	-0.1	-0.3	0.2	-0.2
Guilty feelings	0.6	1.0	1.6	-1.2	1.0	-0.6	1.0
Wears glasses or contact lenses	0.2	0.3	0.5	0.4	-0.7	0.3	-0.6
Ever taken oral contraceptive pill	0.8	0.9	2.3	-1.5	0.8	0.2	0.6
Hearing aid user	0.4	0.5	1.7	-0.2	0.4	1.3	0.4
Mother’s age at death	1.7	2.1	4.3	0.5	-1.4	2.1	-1.5
Financial situation satisfaction	0.6	0.7	1.3	-0.8	0.8	-1.2	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.6	-0.7	0.0	-0.4
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.2	-0.6	-0.2	-0.6
Eye problems/disorders: Glaucoma	0.9	1.0	2.3	0.7	-0.8	1.5	-0.8
Medication: Blood pressure	0.3	0.6	0.8	-0.7	0.7	-0.8	0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.5	0.2	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.9	-2.0	1.8	-0.3	1.7
High cholesterol (Self-reported)	0.6	1.0	1.5	-0.9	0.8	-1.2	1.0
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.2	0.4	-0.1	0.5
Medication: Paracetamol	1.7	2.6	3.4	-1.8	1.5	-1.4	1.6
Medication: Lisinopril	0.1	0.2	0.6	0.7	-0.4	0.1	-0.1
Medication: Atorvastatin	0.3	0.4	1.5	-0.0	0.1	-1.2	0.3
Illnesses of father: High blood pressure	0.4	0.5	0.9	0.9	-0.5	0.8	-0.6
Alcohol drinker status: Never	0.2	0.2	0.5	0.7	-0.4	0.3	-0.4
Ever smoked	0.9	1.6	2.4	-1.3	1.3	-0.8	1.5
Basal metabolic rate	0.4	2.5	4.2	-1.6	2.1	-0.5	1.7
Leg fat percentage (left)	1.0	3.6	5.4	-1.3	2.3	-1.4	2.3
Arm fat-free mass (left)	0.8	4.1	6.9	-2.0	2.6	-0.6	2.3
Number of operations (self-reported)	0.7	1.1	2.1	0.5	-1.4	0.3	-1.5
Average weekly beer plus cider intake	1.1	1.6	2.0	-1.4	1.2	-1.4	1.0
Irritability	0.4	0.7	1.1	0.3	-0.9	0.8	-1.1
Risk taking	0.3	0.4	0.7	0.1	0.6	-0.8	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.7	0.3	-0.9	0.8	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	2.9	-0.4	-0.1	1.7	-0.1
Age started oral contraceptive pill	0.9	1.1	1.8	-1.3	0.8	1.2	0.5
Diastolic blood pressure, automated reading	5.3	16.4	23.4	-3.6	4.7	-2.6	4.8
Ever depressed for a whole week	0.7	0.8	2.0	0.2	-0.7	1.4	-0.8
Unable to work because of sickness or disability	0.6	0.8	2.2	0.5	-0.6	-1.5	-0.7
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.3	-0.8	-0.3	-0.8
Myopia	0.8	1.2	2.0	1.4	-1.0	-0.9	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.6	-0.1	-0.6	1.3	-0.9
Cholesterol lowering medication	0.3	0.4	1.1	-0.4	0.3	-1.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.6	-0.5	0.8	-0.2
Pain experienced in last month	0.1	0.1	0.5	0.3	-0.0	0.7	0.1
Supplements: Calcium	1.4	1.6	2.2	-1.5	1.4	-0.6	1.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	-0.3	0.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.5	-0.1	0.2	-0.1
Heart disease (siblings)	1.7	2.0	2.9	1.1	-1.7	1.1	-1.7
Alcohol drinker status: Previous	1.3	1.5	2.0	-0.2	-1.4	1.4	-1.4
Pack years of smoking	0.4	0.5	1.9	0.3	0.1	-1.4	0.2
Impedance of whole body	1.0	4.8	6.6	2.3	-2.6	1.4	-2.3
Leg fat mass (left)	0.8	3.2	4.9	-1.3	2.2	-1.4	2.1
Arm predicted mass (left)	0.9	4.5	7.4	-2.2	2.7	-0.5	2.4