Hub : Genes

ALOX15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.1339 0.0192 0.0e+00 0.179 0.149 0.170 0.177 0.176 1.6e-55 1.0e-45 2.1e-52 8.7e-55 1.8e-54
2 ROSMAP Brain Pre-frontal Cortex 0.1849 0.0319 3.3e-16 0.211 0.159 0.209 0.206 0.219 1.3e-26 6.5e-20 2.2e-26 7.0e-26 1.3e-27
3 TCGA Bladder Urothelial Carcinoma 0.0570 0.0270 4.1e-03 -0.002 0.024 0.005 NA 0.001 5.0e-01 3.5e-03 1.0e-01 NA 2.3e-01
4 TCGA Brain Lower Grade Glioma 0.0965 0.0321 1.2e-06 0.054 0.049 0.051 NA 0.051 7.9e-07 2.7e-06 1.9e-06 NA 1.8e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.2 0.1 0.0 0.0
Bipolar Disorder or Schizophrenia 0.1 0.2 1.0 1.0 -0.0 0.0 0.0
Depressed Affect (Nagel 2018) 0.2 0.5 1.7 -1.3 0.4 -0.4 0.2
Depression (Nagel 2018) 2.2 3.3 5.0 -2.2 2.0 -1.1 1.7
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 0.9 -0.3 -0.8 -0.2
Neuroticism (Nagel 2018) 0.1 0.1 0.4 -0.7 -0.1 0.1 -0.3
Schizophrenia (2018) 0.2 0.4 1.5 1.2 -0.0 0.0 0.0
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.1 0.0 0.0 0.0
Worry (Nagel 2018) 0.1 0.1 0.3 -0.6 -0.1 0.3 -0.2
Alzheimer’s Disease (in mother) 1.2 1.4 1.7 1.3 -1.3 0.8 -1.3
Alzheimer’s Disease (in father) 0.2 0.3 0.5 0.7 -0.3 -0.0 -0.7
Alzheimer’s Disease (including proxy) 0.9 1.3 2.0 1.3 -1.2 0.3 -1.4
Crohns Disease (2017) 0.7 1.4 2.7 -1.6 1.1 -0.9 1.1
Irritable Bowel Disease (IBD) 3.5 8.2 8.9 -2.9 3.0 -2.9 2.7
Ulcerative Colitis (UC) 4.8 9.1 11.3 -2.6 3.4 -2.9 3.1
Major Depression (MDD) 0.5 0.6 1.3 1.0 -1.1 0.0 0.0
Reaction Time 0.4 0.8 1.4 1.0 -1.0 -0.1 -1.2
Verbal and Numeric Reasoning (VNR) 0.5 1.1 2.1 -0.3 1.0 -1.5 1.1
Breast Cancer 0.1 0.3 0.5 0.7 -0.4 0.6 -0.5
Ovarian Cancer 1.2 1.6 2.1 1.4 -1.1 1.4 -1.0
Prostate Cancer 0.5 0.7 2.1 0.1 0.6 -1.4 0.6
Age at First Birth 0.6 0.9 1.4 1.0 -1.2 0.2 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.7 -0.5 0.7 0.1 0.8
Coronary Artery Disease (CAD) 0.0 0.0 0.1 0.3 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.4 3.1 -1.8 1.6 0.0 0.0
Mean Putamen Volume 1.3 1.5 4.1 0.7 -0.8 2.0 -0.9
Fasting Glucose 0.7 0.8 2.7 0.7 -1.6 0.2 -0.2
HbA1C 0.1 0.1 0.2 -0.4 0.1 -0.2 0.0
HDL Cholesterol 0.1 0.1 0.3 -0.2 0.0 0.6 -0.1
LDL Cholesterol 2.5 3.9 7.0 -2.6 2.0 -0.8 2.0
Lupus 2.1 3.2 4.2 -1.9 2.0 -1.1 2.0
Neuroticism (2016) 1.9 2.7 3.8 -2.0 1.7 -0.9 1.8
Primary Biliary Cirrhosis 0.4 0.6 1.7 -0.4 0.4 -1.3 0.5
Rheumatoid Arthritis 2.4 3.3 7.7 -1.3 1.5 -2.8 1.2
Schizophrenia (2014) 0.1 0.2 0.6 0.7 -0.3 0.0 0.0
Triglycerides 0.2 0.3 0.8 -0.4 0.5 0.1 0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.1 -0.5 0.0 0.0
Ulcerative Colitis 3.1 4.5 11.1 -2.6 3.3 0.0 0.0
Blood Eosinophil Count 11.8 90.7 130.0 11.4 -9.2 9.1 -8.1
Blood Platelet Count 0.3 3.3 4.0 -1.9 2.0 -1.1 2.0
Blood Red Count 0.1 0.7 1.5 1.2 0.3 -1.1 0.1
Blood White Count 3.3 24.8 37.6 -4.7 5.6 -3.0 6.1
Heel T-Score 0.5 3.9 5.7 -2.1 2.4 0.1 2.4
BMI 1.0 6.0 7.9 -1.8 2.8 -2.3 2.8
Height 0.1 1.2 1.8 -0.9 1.2 1.3 0.9
Waist Hip Ratio (WHR) 0.2 0.9 3.1 0.3 0.3 -1.8 0.5
Systolic Blood Pressure 0.6 2.9 4.4 -2.1 1.9 -0.4 1.9
Smoking Status 0.2 0.5 1.2 -0.3 0.7 0.2 1.1
Allergy or Eczema 0.1 0.2 0.4 0.4 0.5 -0.3 0.6
Cardiovascular Disease 0.0 0.1 0.3 0.5 -0.3 -0.4 0.2
Hypothyroidism (self reported) 0.2 0.4 0.7 -0.8 0.6 -0.5 0.6
Respiratory disease 0.6 1.4 2.2 -1.5 1.2 0.7 1.2
Type 2 Diabetes (T2D) (2018) 2.0 3.8 4.5 1.9 -2.1 1.6 -2.1
Lung FEV1/FVC ratio 0.1 0.4 1.2 -0.3 0.6 0.1 1.1
Lung FVC 0.4 2.2 4.8 -2.2 1.5 0.7 1.2
Neuroticism 0.1 0.3 0.9 -1.0 0.5 0.1 0.4
Chronotype (morning person) 0.9 2.0 4.6 0.8 -1.3 2.1 -1.1
Hair Pigment 0.0 0.7 1.3 -0.5 0.9 1.1 0.7
Tanning 0.0 0.2 0.7 -0.3 -0.3 0.8 -0.0
Hand grip strength (left) 0.5 1.3 2.1 -1.5 1.2 0.9 0.9
Number of treatments/medications taken 0.8 1.4 1.9 -0.7 1.2 -1.4 1.4
Average weekly spirits intake 0.6 0.7 1.3 0.8 -0.8 1.1 -0.5
Sensitivity / hurt feelings 0.1 0.1 0.4 0.2 0.1 -0.6 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.9 -0.9 0.8 -0.2 0.7
Hearing difficulty/problems: Yes 2.0 3.1 4.4 -1.7 2.0 -1.2 2.1
Relative age of first facial hair 0.2 0.4 0.8 -0.3 0.6 -0.6 0.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.5 -0.3 -0.0 -0.7 -0.1
Ever used hormone-replacement therapy (HRT) 1.9 2.4 3.4 -1.6 1.9 -0.4 1.9
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.4 0.5 0.1 0.2
Systolic blood pressure, automated reading 2.1 6.1 8.4 -2.5 2.9 -1.4 2.8
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.0 -1.2 1.3 -0.7 1.4
Angina 0.4 0.6 2.0 -0.4 -0.1 -1.4 -0.2
Medication for hormone replacement therapy 0.3 0.3 0.6 0.8 0.3 -0.5 0.5
Vitamin and mineral supplements 0.7 1.0 1.5 1.1 -1.2 -0.1 -1.1
Supplements: Zinc 0.1 0.1 0.2 -0.3 0.3 0.1 0.4
Medication: Co-codamol 0.1 0.1 0.2 -0.1 -0.3 -0.5 -0.3
Medication: Metformin 1.2 1.7 2.6 1.6 -1.2 1.2 -1.2
Diabetes (father) 3.3 4.1 8.4 2.0 -1.5 2.9 -1.3
Diabetes (mother) 0.7 0.9 1.3 1.0 -1.1 -0.1 -1.1
Severe depression (siblings) 2.9 3.2 4.6 1.7 -1.7 2.1 -1.6
Pack years adult smoking proportion 0.3 0.4 1.5 0.5 -0.1 -1.2 0.1
Impedance of leg (right) 0.4 1.9 3.1 1.8 -1.6 0.8 -1.2
Leg fat-free mass (left) 0.3 1.6 2.7 -1.2 1.6 -0.8 1.3
Trunk fat percentage 0.2 0.6 1.0 -0.1 1.0 -0.7 1.0
Hand grip strength (right) 0.9 2.3 4.2 -2.0 1.5 1.1 1.3
Townsend deprivation index at recruitment 0.3 0.4 1.2 -0.4 0.2 -1.1 0.0
Current tobacco smoking 0.5 0.8 2.2 0.9 -0.3 1.5 0.1
Average weekly fortified wine intake 0.5 0.6 2.2 0.1 0.3 1.5 0.4
Maternal smoking around birth 1.3 1.9 2.4 -1.2 1.3 -1.6 1.4
Fed-up feelings 0.5 1.0 2.2 -1.5 0.8 -1.0 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 1.6 -1.1 1.0 -1.3 0.9
Relative age voice broke 0.3 0.5 0.8 -0.4 0.8 -0.6 0.9
Taking other prescription medications 0.0 0.0 0.1 -0.2 0.0 -0.2 0.3
Age when periods started (menarche) 1.6 3.8 5.2 -2.3 2.1 -1.1 2.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 0.8 -0.8 0.3 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 4.0 -1.4 1.8 -1.0 2.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.7 0.2 0.5 0.3
Qualifications: CSEs or equivalent 0.8 1.0 2.7 -0.9 0.6 -1.6 0.5
Serious illness, injury or assault to yourself 0.7 0.8 2.4 -0.7 -0.5 1.5 -0.6
High blood pressure 0.2 0.6 1.0 0.2 0.7 -1.0 1.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 -0.5 0.6 -1.2 0.5
Multivitamins +/- minerals 0.7 0.9 1.4 -1.2 1.1 -0.3 0.9
Stomach or abdominal pain in last month 0.6 0.7 0.9 0.9 -0.8 0.7 -0.9
Supplements: Glucosamine 0.1 0.2 0.6 -0.1 -0.0 -0.8 -0.2
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 3.2 -1.6 1.8 -1.6 1.6
Medication: Atenolol 0.6 0.8 1.2 -0.9 1.0 0.1 1.1
Medication: Levothyroxine sodium 0.5 0.8 2.0 -0.5 0.7 -1.4 0.8
Sitting height 0.6 4.4 7.8 -2.8 2.3 -0.6 2.1
Chronic bronchitis/emphysema (father) 0.4 0.4 0.7 -0.4 -0.6 0.8 -0.6
High blood pressure (mother) 2.9 4.1 5.2 2.3 -2.1 1.2 -2.3
Body mass index (BMI) 0.9 3.7 5.3 -1.4 2.3 -1.7 2.2
Impedance of leg (left) 0.3 1.7 2.3 1.5 -1.5 1.0 -1.1
Leg predicted mass (left) 0.3 1.7 2.8 -1.3 1.7 -0.8 1.4
Trunk fat mass 0.3 1.4 2.4 -0.6 1.5 -0.9 1.4
Waist circumference 0.6 2.3 2.9 -0.9 1.7 -1.7 1.6
Number of incorrect matches in round 0.8 1.4 1.9 -1.3 1.4 0.3 1.3
Past tobacco smoking 0.6 1.1 1.4 1.0 -1.0 1.0 -1.2
Alcohol usually taken with meals 0.0 0.1 0.1 0.2 0.2 -0.2 0.3
Nervous feelings 0.3 0.5 1.0 0.3 -0.8 0.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.5 -0.8 0.9 -1.2 1.1
Hearing difficulty/problems with background noise 3.9 6.2 8.5 -2.6 2.2 -2.9 2.1
Hair/balding pattern: Pattern 2 3.1 3.9 4.6 1.7 -2.1 2.0 -2.1
Had menopause 0.2 0.2 0.3 -0.6 0.6 -0.2 0.3
Had other major operations 0.3 0.3 0.6 -0.8 0.4 -0.5 0.5
Forced vital capacity (FVC) 0.1 0.5 1.3 -1.1 0.6 -0.2 0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 4.5 -1.7 2.0 -1.2 2.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 -0.1 -0.5 0.2 -0.6
Qualifications: None of the above 0.1 0.2 0.3 -0.3 -0.3 -0.5 -0.4
Financial difficulties in last 2 years 1.6 2.2 3.5 -1.4 1.8 -0.3 1.9
Mouth/teeth dental problems 2.0 3.1 4.2 1.7 -2.0 1.3 -1.8
Heart attack 0.1 0.1 0.1 -0.3 0.1 -0.2 0.3
Allergy 0.4 0.8 2.0 0.6 -0.7 1.4 -0.7
Pain all over the body in last month 0.1 0.1 0.3 0.5 -0.1 0.4 -0.0
Diabetes (self-reported) 0.7 1.1 1.5 1.2 -1.2 0.2 -1.1
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.7 0.9 -1.3 -0.2 -1.2
Medication: Ramipril 1.1 1.4 2.5 1.6 -1.5 -0.1 -1.0
Medication: Simvastatin 0.1 0.2 0.3 0.6 -0.5 -0.1 -0.3
Fluid intelligence score 1.7 3.5 5.0 -1.2 1.9 -2.2 2.0
Illnesses of siblings 1.1 1.6 2.3 1.5 -1.4 -0.1 -1.4
Neuroticism score 0.1 0.2 0.7 -0.8 0.2 -0.5 0.1
Weight 0.6 2.9 4.8 -1.4 2.2 -1.1 1.9
Impedance of arm (right) 1.3 6.2 8.4 2.3 -2.9 1.8 -2.8
Arm fat percentage (right) 0.2 0.7 1.3 -0.4 1.1 -0.5 1.0
Trunk fat-free mass 0.5 3.1 5.0 -1.9 2.2 -0.5 1.9
Hip circumference 0.1 0.5 1.2 -0.4 1.1 -0.1 0.9
Time employed in main current job 0.2 0.3 0.7 0.2 -0.4 0.8 -0.4
Alcohol intake versus 10 years previously 0.5 0.7 2.9 0.2 -0.2 -1.7 -0.2
Father’s age at death 0.1 0.1 0.2 -0.0 -0.2 -0.2 -0.4
Worrier / anxious feelings 0.2 0.3 0.6 -0.5 -0.4 0.7 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.5 -0.7 0.3 -0.5
Falls in the last year 0.9 1.2 2.2 0.5 -1.2 0.9 -1.5
Hair/balding pattern: Pattern 3 1.4 2.2 7.5 -0.7 0.8 -2.7 0.4
Number of live births 0.5 0.7 1.4 -0.9 0.6 -1.2 0.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 0.7 -0.8 0.8 -0.2 0.7
Pulse rate 0.4 0.6 1.3 -0.2 1.1 -0.0 1.2
Happiness 3.0 3.7 5.9 1.7 -2.3 0.7 -2.4
Noisy workplace 1.3 1.6 3.0 -1.1 1.1 -1.7 1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.4 1.0 -0.4 -1.6 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.4 -0.0 -0.0 -0.2
Mouth/teeth dental problems: Dentures 1.8 3.0 5.9 -2.4 1.9 -0.6 1.5
Asthma 0.3 0.6 1.1 -0.9 0.8 0.1 1.1
Medication: Ibuprofen (e.g. Nurofen) 2.8 3.6 4.3 -2.0 2.1 -1.7 1.8
Medication: Cholesterol lowering 0.2 0.3 0.8 0.5 -0.1 -0.9 0.3
Depression (self-reported) 2.4 2.8 4.3 1.4 -2.0 1.0 -2.1
Medication: Lansoprazole 0.6 0.7 1.6 1.2 -0.8 -0.6 -0.6
Prospective memory result 2.6 3.2 3.5 1.9 -1.8 1.9 -1.6
Lung cancer (father) 0.4 0.4 1.0 -0.6 0.6 0.4 1.0
Illnesses of mother 2.6 3.3 5.2 -2.3 1.8 -1.5 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.0 -0.1 0.1 0.1 0.1
Pulse wave Arterial Stiffness index 0.3 0.3 0.7 0.0 0.7 -0.5 0.8
Impedance of arm (left) 1.6 7.3 10.3 2.9 -3.2 1.4 -3.0
Arm fat mass (right) 0.4 1.7 2.9 -0.9 1.7 -0.8 1.5
Trunk predicted mass 0.5 2.8 4.4 -1.9 2.1 -0.4 1.8
Standing height 0.0 0.4 1.5 0.0 -0.1 1.2 -0.4
Length of working week for main job 3.2 3.5 5.0 -2.0 2.2 -0.0 2.2
Exposure to tobacco smoke at home 1.1 1.2 4.6 0.2 -0.4 2.1 -0.2
Breastfed as a baby 0.6 0.8 1.6 -0.8 0.7 -1.3 0.5
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.3 0.1 0.3 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 4.9 1.2 -1.5 2.2 -1.6
Hair/balding pattern: Pattern 4 1.1 2.8 4.5 -1.3 1.8 -1.2 2.1
Birth weight of first child 0.5 0.8 1.2 0.5 -1.0 1.1 -1.0
Peak expiratory flow (PEF) 0.9 2.1 3.6 -1.1 1.8 -0.7 1.9
Pulse wave reflection index 0.3 0.3 0.5 -0.4 0.5 -0.7 0.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.2 1.0 -1.0 -0.2 -1.1
Loud music exposure frequency 0.3 0.3 0.5 -0.5 0.5 -0.7 0.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.0 0.3 -0.4 1.0 -0.7
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.2 -0.4 1.0 -1.8 0.8
Blood clot in the leg (DVT) 0.0 0.0 0.1 0.0 0.3 -0.1 0.2
Medication: Paracetamol 1.8 3.0 4.5 -2.1 1.7 -1.3 1.7
Headache pain in last month 1.3 2.3 3.4 1.9 -1.7 0.1 -1.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 -0.8 -0.0 1.5 -0.3
Glaucoma (self-reported) 2.8 3.3 4.7 2.2 -1.7 1.7 -1.7
Gout (self-reported) 0.5 0.7 1.3 -1.1 0.8 -0.1 0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 -0.7 0.6 -0.5 0.6
Medication: Amlodipine 0.5 0.7 0.8 0.8 -0.9 0.7 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.5 -1.2 0.9 -0.4 1.0
Birth weight 2.8 6.0 10.6 1.3 -2.3 3.3 -2.5
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.5 0.1 -0.2 -0.7 0.0
High blood pressure (siblings) 5.5 8.0 10.8 -3.3 3.3 -1.2 3.0
Forced vital capacity (FVC), Best measure 0.0 0.1 0.1 -0.3 -0.1 -0.0 -0.3
Body fat percentage 0.3 1.1 1.8 -0.4 1.4 -0.9 1.3
Leg fat percentage (right) 1.0 3.6 5.4 -1.1 2.3 -1.6 2.3
Arm fat-free mass (right) 0.8 3.9 6.4 -2.0 2.5 -0.7 2.2
Exposure to tobacco smoke outside home 2.0 2.7 5.0 -1.4 1.4 -2.2 1.3
Comparative body size at age 10 0.1 0.2 0.3 -0.6 0.6 0.0 0.2
Number of full brothers 0.0 0.1 0.2 -0.2 -0.1 0.4 -0.0
Worry too long after embarrassment 0.7 1.2 1.6 -1.2 1.2 -0.6 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.3 -0.1 0.8 -0.5
Wheeze or whistling in the chest in last year 1.1 2.0 3.6 -1.1 1.5 -1.0 1.9
Number of children fathered 3.5 4.0 4.8 -2.0 1.9 -2.2 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.1 0.1 -0.6 0.0
Age at first live birth 0.1 0.2 0.7 -0.1 -0.1 -0.8 -0.3
Pulse wave peak to peak time 0.2 0.2 0.4 -0.1 -0.5 0.4 -0.7
Health satisfaction 1.2 1.6 2.9 -1.7 1.0 -1.1 1.0
Shortness of breath walking on level ground 0.4 0.5 1.0 -1.0 0.4 -1.0 0.2
Qualifications: College or University degree 0.0 0.1 0.4 0.6 -0.1 -0.1 -0.2
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.1 -0.1 -0.4 -0.4
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 -0.1 -0.2 0.2 -0.3
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.5 0.4 -0.2 0.3
Medication for pain relief, constipation, heartburn 2.2 3.7 4.9 2.2 -2.0 0.9 -2.2
Neck or shoulder pain in last month 3.4 4.8 6.4 -2.5 2.1 -2.1 2.0
Medication: Blood pressure 0.2 0.3 0.3 0.6 0.4 -0.5 0.6
Angina (self-reported) 0.5 0.7 2.6 -0.3 -0.0 -1.6 -0.1
Migraine (self-reported) 2.3 2.8 5.9 1.2 -2.0 0.0 -2.4
Medication: Ibuprofen 2.9 3.4 3.8 -1.7 2.0 -1.9 1.8
Medication: Allopurinol 0.2 0.3 1.0 -0.2 -0.3 1.0 -0.2
Medication: Omeprazole 0.3 0.4 0.9 -0.4 0.7 0.3 0.9
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.6 0.1 0.4 -0.3
Mean time to correctly identify matches 0.1 0.3 0.5 0.3 -0.4 -0.5 -0.7
Heart disease (mother) 0.5 0.6 0.9 1.0 -0.5 1.0 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 3.6 -1.9 1.4 -1.5 1.5
Whole body fat mass 0.5 2.0 3.3 -0.9 1.8 -1.1 1.7
Leg fat mass (right) 0.9 3.5 5.4 -1.2 2.3 -1.6 2.2
Arm predicted mass (right) 1.1 5.7 8.9 -2.4 3.0 -1.0 2.7
Pulse rate, automated reading 0.4 1.2 2.4 -0.6 1.4 0.3 1.6
Alcohol intake frequency. 0.7 1.5 2.2 1.2 -1.4 0.7 -1.5
Comparative height size at age 10 0.3 1.4 3.3 1.1 -0.8 1.8 -0.7
Number of full sisters 1.4 1.6 4.3 0.9 -0.8 2.1 -0.9
Suffer from ‘nerves’ 0.0 0.0 0.0 -0.0 0.1 -0.2 0.1
Overall health rating 0.9 2.0 5.0 -0.7 1.0 -2.2 1.2
Chest pain or discomfort 1.1 1.6 3.2 1.8 -1.3 0.2 -1.2
Had major operations 0.4 0.5 1.0 0.5 -0.8 0.4 -1.0
Age at last live birth 0.3 0.4 1.3 0.1 -0.2 -1.1 -0.4
Family relationship satisfaction 0.2 0.3 0.4 0.4 -0.5 0.6 -0.6
Leg pain on walking 0.2 0.2 0.8 -0.4 0.1 -0.9 -0.0
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.9 -1.0 1.4 -0.8 1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.7 0.9 -0.3 0.6 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 0.6 -0.0 -0.3 0.1
Medication: Aspirin 1.1 1.4 2.9 -0.9 1.3 -0.6 1.7
Supplements: Vitamin C 0.5 0.6 1.3 -0.4 0.8 0.6 1.1
Knee pain experienced in last month 1.3 2.0 2.6 -1.3 1.4 -1.6 1.4
Hypertension (Self-reported) 0.1 0.4 0.6 0.4 0.4 -0.7 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.5 0.7 0.1 0.1 -0.3
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.6 0.6 -0.8 0.4
Illnesses of siblings: Diabetes 2.2 2.7 5.2 1.3 -1.4 2.3 -1.4
Smoking status: Previous 0.5 0.8 1.5 -1.0 0.6 -1.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.7 0.2 -0.8 0.6 -0.7
Whole body fat-free mass 0.5 2.8 4.6 -1.8 2.1 -0.6 1.8
Leg fat-free mass (right) 0.4 1.9 3.1 -1.4 1.8 -0.7 1.4
Arm fat percentage (left) 0.1 0.6 0.9 -0.2 1.0 -0.8 0.9
Average weekly red wine intake 0.1 0.2 0.6 -0.3 0.4 -0.0 0.7
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.8 -0.9 1.0 1.4 0.8
Mood swings 0.2 0.4 0.6 -0.6 -0.5 0.5 -0.8
Loneliness, isolation 0.2 0.3 1.0 -1.0 0.4 -0.4 0.1
Long-standing illness, disability or infirmity 1.0 1.5 3.3 -1.2 0.7 -1.8 0.8
Ever had bowel cancer screening 0.8 1.0 1.3 -1.1 1.1 -0.4 1.1
Diabetes diagnosed by doctor 0.4 0.6 1.0 1.0 -0.9 0.3 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.7 0.1 -0.1 -1.3 0.1
Friendships satisfaction 0.2 0.3 0.3 -0.4 -0.5 -0.6 -0.5
Qualifications: nursing, teaching 0.4 0.6 1.2 -0.3 1.0 0.1 1.1
Commuting to job workplace: Walk 2.6 2.8 3.9 1.8 -1.8 1.0 -2.0
Eye problems/disorders: Cataract 0.5 0.6 1.3 -0.5 0.8 0.1 1.2
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 2.2 -1.2 1.4 -0.5 1.5
Medication for cholesterol 0.1 0.1 0.2 -0.4 0.3 0.5 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 4.5 -1.4 1.5 -2.1 1.7
Back pain experienced in last month 0.2 0.3 0.8 -0.9 0.3 -0.7 0.1
Mineral and other dietary supplements 4.5 6.0 8.6 2.6 -2.9 0.9 -2.7
Breast cancer (self-reported) 0.1 0.1 0.2 -0.1 0.3 -0.0 0.5
Asthma (self-reported) 0.3 0.6 0.9 -0.9 0.8 0.4 1.0
Osteoporosis (self-reported) 0.7 0.8 2.6 -0.9 0.1 -1.6 -0.2
Osteoarthritis (self-reported) 0.3 0.4 1.3 -0.5 0.1 -1.1 -0.2
Medication: Aspirin 0.5 0.7 1.4 -0.4 0.8 -0.6 1.2
Medication: Gliclazide 0.6 0.7 1.2 0.7 -1.1 0.2 -1.1
Illnesses of father: None of the above (group 1) 2.0 2.4 3.2 -1.7 1.4 -1.3 1.8
Smoking status: Current 0.4 0.6 1.9 0.5 0.0 1.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.2 -1.0 0.8 -1.1 0.8
Whole body water mass 0.5 2.6 4.3 -1.7 2.1 -0.6 1.7
Leg predicted mass (right) 0.4 1.9 3.1 -1.5 1.8 -0.6 1.4
Arm fat mass (left) 0.3 1.4 2.5 -0.7 1.6 -0.8 1.4
Number of self-reported non-cancer illnesses 0.3 0.5 1.5 -0.2 0.3 -1.2 0.4
Average weekly champagne plus white wine intake 1.0 1.4 2.0 1.4 -1.3 0.5 -1.4
Miserableness 0.0 0.1 0.1 -0.1 -0.3 0.2 -0.2
Guilty feelings 0.6 1.0 1.6 -1.2 1.0 -0.6 1.0
Wears glasses or contact lenses 0.2 0.3 0.5 0.4 -0.7 0.3 -0.6
Ever taken oral contraceptive pill 0.8 0.9 2.3 -1.5 0.8 0.2 0.6
Hearing aid user 0.4 0.5 1.7 -0.2 0.4 1.3 0.4
Mother’s age at death 1.7 2.1 4.3 0.5 -1.4 2.1 -1.5
Financial situation satisfaction 0.6 0.7 1.3 -0.8 0.8 -1.2 0.6
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 0.6 -0.7 0.0 -0.4
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.2 -0.6 -0.2 -0.6
Eye problems/disorders: Glaucoma 0.9 1.0 2.3 0.7 -0.8 1.5 -0.8
Medication: Blood pressure 0.3 0.6 0.8 -0.7 0.7 -0.8 0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 -0.5 0.2 -0.3 0.2
Supplements: Fish oil (including cod liver oil) 1.9 2.5 3.9 -2.0 1.8 -0.3 1.7
High cholesterol (Self-reported) 0.6 1.0 1.5 -0.9 0.8 -1.2 1.0
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.2 0.4 -0.1 0.5
Medication: Paracetamol 1.7 2.6 3.4 -1.8 1.5 -1.4 1.6
Medication: Lisinopril 0.1 0.2 0.6 0.7 -0.4 0.1 -0.1
Medication: Atorvastatin 0.3 0.4 1.5 -0.0 0.1 -1.2 0.3
Illnesses of father: High blood pressure 0.4 0.5 0.9 0.9 -0.5 0.8 -0.6
Alcohol drinker status: Never 0.2 0.2 0.5 0.7 -0.4 0.3 -0.4
Ever smoked 0.9 1.6 2.4 -1.3 1.3 -0.8 1.5
Basal metabolic rate 0.4 2.5 4.2 -1.6 2.1 -0.5 1.7
Leg fat percentage (left) 1.0 3.6 5.4 -1.3 2.3 -1.4 2.3
Arm fat-free mass (left) 0.8 4.1 6.9 -2.0 2.6 -0.6 2.3
Number of operations (self-reported) 0.7 1.1 2.1 0.5 -1.4 0.3 -1.5
Average weekly beer plus cider intake 1.1 1.6 2.0 -1.4 1.2 -1.4 1.0
Irritability 0.4 0.7 1.1 0.3 -0.9 0.8 -1.1
Risk taking 0.3 0.4 0.7 0.1 0.6 -0.8 0.8
Ever had prostate specific antigen (PSA) test 0.5 0.5 0.7 0.3 -0.9 0.8 -0.8
Fractured/broken bones in last 5 years 0.6 0.8 2.9 -0.4 -0.1 1.7 -0.1
Age started oral contraceptive pill 0.9 1.1 1.8 -1.3 0.8 1.2 0.5
Diastolic blood pressure, automated reading 5.3 16.4 23.4 -3.6 4.7 -2.6 4.8
Ever depressed for a whole week 0.7 0.8 2.0 0.2 -0.7 1.4 -0.8
Unable to work because of sickness or disability 0.6 0.8 2.2 0.5 -0.6 -1.5 -0.7
Commuting to job workplace: Cycle 0.3 0.4 0.7 0.3 -0.8 -0.3 -0.8
Myopia 0.8 1.2 2.0 1.4 -1.0 -0.9 -1.1
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.6 -0.1 -0.6 1.3 -0.9
Cholesterol lowering medication 0.3 0.4 1.1 -0.4 0.3 -1.1 0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 0.6 -0.5 0.8 -0.2
Pain experienced in last month 0.1 0.1 0.5 0.3 -0.0 0.7 0.1
Supplements: Calcium 1.4 1.6 2.2 -1.5 1.4 -0.6 1.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 -0.4 -0.3 0.0 -0.2
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.2 -0.2 -0.2 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.5 -0.1 0.2 -0.1
Heart disease (siblings) 1.7 2.0 2.9 1.1 -1.7 1.1 -1.7
Alcohol drinker status: Previous 1.3 1.5 2.0 -0.2 -1.4 1.4 -1.4
Pack years of smoking 0.4 0.5 1.9 0.3 0.1 -1.4 0.2
Impedance of whole body 1.0 4.8 6.6 2.3 -2.6 1.4 -2.3
Leg fat mass (left) 0.8 3.2 4.9 -1.3 2.2 -1.4 2.1
Arm predicted mass (left) 0.9 4.5 7.4 -2.2 2.7 -0.5 2.4