TWAS hub - RAB4B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1820	0.0660	3.5e-03	0.035	NA	0.102	NA	0.095	4.9e-03	NA	3.0e-06	NA	6.6e-06
2	YFS	Blood	0.0475	0.0132	2.4e-07	0.021	0.022	0.015	0.021	0.014	1.2e-07	6.4e-08	5.5e-06	1.1e-07	1.4e-05
3	TCGA	Breast Invasive Carcinoma	0.0230	0.0113	4.8e-04	0.003	0.010	0.011	NA	0.012	6.3e-02	3.0e-03	1.9e-03	NA	1.5e-03
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0684	0.0278	5.4e-05	0.047	0.050	0.043	NA	0.039	5.0e-06	2.7e-06	1.2e-05	NA	2.9e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1046	0.0380	4.9e-08	0.070	0.066	0.069	NA	0.078	2.4e-08	6.1e-08	3.2e-08	NA	4.2e-09
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1770	0.0610	5.1e-07	0.104	0.105	0.097	NA	0.106	1.5e-06	1.4e-06	3.5e-06	NA	1.2e-06
7	TCGA	Brain Lower Grade Glioma	0.0623	0.0248	7.0e-06	0.034	0.042	0.043	NA	0.043	8.8e-05	1.3e-05	1.1e-05	NA	1.1e-05
8	TCGA	Lung Adenocarcinoma	0.0323	0.0175	1.3e-03	0.000	0.012	0.017	NA	0.005	3.2e-01	1.2e-02	3.9e-03	NA	7.9e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0600	0.0310	1.3e-03	0.017	0.019	0.005	NA	0.017	2.3e-02	1.7e-02	1.5e-01	NA	2.4e-02
10	TCGA	Prostate Adenocarcinoma	0.0667	0.0277	5.4e-07	0.044	0.055	0.048	NA	0.043	2.0e-05	2.0e-06	9.3e-06	NA	2.4e-05
11	TCGA	Thyroid Carcinoma	0.1370	0.0460	1.3e-07	0.033	0.065	0.059	NA	0.057	3.4e-04	6.5e-07	2.0e-06	NA	3.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Pack years of smoking	6.9	10.1	37.1	-2.0	-0.5	-1.7	-2.9	-5.5	-3.2	-3.6	-1.8	-0.7	-1.5	-6.1
Pain experienced in last month	6.8	11.3	20.9	3.6	-2.3	3.2	1.7	4.6	4.2	4.5	2.7	4.0	2.9	2.0
Current tobacco smoking	6.3	10.3	33.0	1.4	-2.4	3.4	1.6	3.7	2.9	3.0	2.6	2.5	3.8	5.7
Pack years adult smoking proportion	6.1	9.3	34.0	-1.9	-0.5	-1.7	-2.6	-5.3	-3.1	-3.4	-1.7	-0.7	-1.5	-5.8
Medication: Allopurinol	5.5	7.3	11.4	2.5	-1.4	2.3	2.2	3.4	3.0	3.4	2.4	2.5	2.8	3.4
Chest pain or discomfort	5.2	7.5	11.2	-3.1	1.3	-2.4	-2.2	-3.0	-3.3	-3.3	-2.6	-3.3	-2.9	-1.9
Maternal smoking around birth	5.0	7.3	11.0	1.0	-1.1	2.7	1.7	3.3	3.1	3.1	2.8	3.0	3.1	3.3
Smoking status: Previous	4.6	6.9	22.0	-1.8	0.7	-1.3	-2.3	-4.4	-2.7	-2.6	-1.9	-1.4	-1.9	-4.7
Smoking status: Current	4.5	7.2	24.6	1.0	-2.3	2.7	1.3	2.8	2.2	2.4	2.2	2.1	3.4	5.0
Prostate Cancer	4.2	5.8	9.7	-0.8	3.1	-2.6	-2.4	-1.6	-2.9	-2.3	-3.0	-3.0	-2.5	-0.7
Lung FEV1/FVC ratio	4.0	20.2	39.7	2.4	-3.8	5.0	3.3	6.3	5.5	5.2	3.7	4.2	3.8	4.9
Medication for hormone replacement therapy	4.0	4.5	11.1	-0.0	-2.1	3.2	2.3	1.5	1.7	1.1	2.0	1.4	2.5	3.3
Pulse wave Arterial Stiffness index	3.8	4.5	12.1	-1.7	3.5	-1.8	-2.0	-2.5	-2.4	-2.4	-1.6	-1.9	-1.4	-1.1
Leg pain on walking	3.7	4.6	6.3	-2.5	0.5	-1.6	-2.4	-2.0	-2.5	-2.4	-2.3	-2.0	-2.1	-2.3
Gout (self-reported)	3.6	5.0	10.5	2.1	-1.5	2.1	1.6	2.8	2.3	2.6	1.6	1.7	2.2	3.2
Commuting to job workplace: Walk	3.4	3.7	9.2	0.2	-0.2	2.3	0.9	0.4	1.9	2.3	2.5	2.9	3.0	1.4
Number of self-reported non-cancer illnesses	3.4	6.0	10.1	-3.2	0.5	-2.3	-2.7	-3.0	-2.7	-2.7	-1.9	-1.7	-2.0	-2.9
Medication: Ventolin 100micrograms inhaler	3.3	4.3	8.3	-1.4	0.7	-2.7	-1.5	-2.0	-2.0	-2.0	-2.1	-1.8	-2.6	-2.9
Pulse wave peak to peak time	3.2	3.8	12.5	1.5	-3.5	1.7	2.0	2.2	2.1	2.0	1.3	1.6	1.2	1.0
Average weekly red wine intake	3.1	4.6	6.9	-2.6	1.1	-1.8	-1.1	-2.6	-2.6	-2.5	-2.2	-2.5	-2.0	-1.8
Past tobacco smoking	2.9	5.4	15.8	2.1	0.3	1.3	2.2	4.0	2.5	2.3	1.6	1.0	1.3	3.9
Medication: Ibuprofen	2.9	3.5	7.0	-1.8	0.3	-1.5	-0.6	-2.4	-2.1	-2.6	-1.2	-2.4	-2.0	-2.0
Respiratory disease	2.8	6.3	10.9	-2.5	-0.2	-3.0	-0.7	-2.7	-2.5	-3.1	-2.1	-3.0	-3.3	-2.5
Blood clot in the leg (DVT)	2.8	3.6	6.3	-0.8	1.6	-2.5	-1.3	-1.8	-2.1	-2.0	-1.8	-2.1	-2.4	-1.8
Mean Putamen Volume	2.7	3.1	5.6	1.1	-0.9	2.3	1.6	1.8	1.9	2.0	1.7	1.3	1.9	2.4
Number of treatments/medications taken	2.6	4.7	10.1	-3.1	1.3	-1.8	-2.3	-3.2	-2.7	-2.2	-1.6	-1.5	-1.2	-1.9
Back pain experienced in last month	2.6	3.8	6.4	-1.5	2.0	-1.9	-1.6	-1.8	-2.0	-2.1	-2.2	-2.5	-2.1	-1.4
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	6.1	-0.6	1.4	-2.5	-1.2	-1.6	-2.0	-2.0	-1.8	-2.1	-2.4	-1.7
Wheeze or whistling in the chest in last year	2.5	4.5	13.1	-3.6	0.4	-1.4	-2.5	-2.3	-2.4	-2.4	-1.8	-1.4	-1.4	-2.0
Type 2 Diabetes (T2D) (2012)	2.4	2.8	8.3	-0.8	-2.2	-1.0	-2.0	-1.7	-1.0	-2.2	-1.0	-0.6	-1.4	-2.9
Medication: Atorvastatin	2.4	3.0	7.5	0.7	0.3	1.4	0.5	2.5	2.1	2.7	1.2	2.2	1.8	1.7
Blood Eosinophil Count	2.3	18.1	34.0	0.6	3.4	-5.5	-3.6	-2.7	-5.0	-3.5	-5.8	-5.8	-5.3	-1.9
Medication: Paracetamol	2.3	3.6	6.2	-2.5	1.3	-2.3	-1.1	-2.5	-2.0	-1.8	-1.4	-1.8	-1.8	-1.9
Average weekly beer plus cider intake	2.3	3.3	5.5	1.2	-1.0	1.6	0.9	2.4	1.9	2.2	1.9	2.3	2.0	2.0
Asthma	2.2	4.2	9.9	-1.9	-0.5	-2.7	-0.6	-1.5	-1.9	-2.4	-2.2	-3.1	-2.9	-0.8
Medication: Seretide 50 evohaler	2.2	2.5	6.7	-1.4	2.0	-2.6	-0.8	-1.8	-1.6	-1.3	-1.2	-1.6	-1.5	-0.8
Number of full sisters	2.2	2.7	10.3	-3.2	1.9	-0.4	-1.6	-1.9	-1.4	-1.7	-1.0	-1.1	-0.8	-0.9
Knee pain experienced in last month	2.2	3.4	9.5	-1.4	0.5	-0.9	-1.3	-3.1	-2.2	-3.0	-1.2	-1.8	-1.4	-1.6
Chronotype (morning person)	2.1	4.9	9.1	-3.0	2.3	-2.5	-1.6	-2.6	-2.2	-2.1	-1.3	-1.5	-1.7	-2.7
Emphysema/chronic bronchitis	2.1	2.4	6.6	-1.8	-0.3	-1.1	-0.9	-1.9	-1.4	-1.7	-1.3	-1.1	-1.8	-2.6
Medication for pain relief, constipation, heartburn	2.1	3.7	8.5	2.2	-1.1	1.9	1.5	2.3	2.1	1.8	1.5	1.5	1.7	2.9
Breast cancer (self-reported)	2.1	2.5	4.4	-0.9	0.7	-1.1	-2.1	-1.5	-2.1	-2.0	-1.9	-1.5	-1.3	-1.5
Asthma (self-reported)	2.1	4.2	9.2	-1.8	-0.4	-2.7	-0.7	-1.6	-2.0	-2.5	-2.1	-3.0	-2.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	5.2	-1.3	0.2	-1.4	-0.1	-1.9	-1.8	-2.3	-0.9	-2.1	-1.9	-1.6
Medication: Paracetamol	2.0	3.3	5.1	-2.2	1.8	-2.3	-0.6	-1.9	-1.8	-1.5	-1.5	-1.9	-2.0	-1.9
Number of full brothers	2.0	2.6	4.8	-1.3	1.8	-1.9	-2.0	-2.2	-1.8	-1.0	-1.3	-0.7	-0.8	-1.9
Sensitivity / hurt feelings	1.9	3.3	9.1	2.2	-0.4	0.7	1.4	3.0	2.3	2.4	1.2	0.9	1.1	2.2
Alcohol intake versus 10 years previously	1.9	2.8	6.6	1.4	-0.5	1.2	0.4	2.4	1.6	2.6	1.2	2.2	2.0	1.0
Worrier / anxious feelings	1.9	3.6	11.2	2.5	1.3	0.4	2.4	3.3	1.8	1.9	0.2	-0.6	-0.3	2.7
Ever smoked	1.9	3.3	10.1	-1.7	-1.2	-1.1	-1.6	-3.0	-1.7	-1.9	-1.0	-0.8	-1.1	-3.2
Irritability	1.9	3.1	6.5	1.4	0.8	1.2	0.8	2.0	1.9	2.5	1.6	1.9	2.1	2.4
Medication: Co-codamol	1.8	2.1	5.0	0.2	1.0	-1.0	-1.1	-2.2	-1.8	-1.9	-1.5	-1.3	-1.1	-1.6
Happiness	1.8	2.1	4.8	2.2	-0.3	0.6	1.9	2.0	1.7	1.6	0.9	0.5	0.6	1.8
Noisy workplace	1.8	2.2	5.4	0.9	-0.1	1.5	2.0	1.8	1.7	1.4	1.4	0.6	1.2	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	5.3	1.3	0.7	2.0	1.0	1.0	1.2	1.3	1.3	1.3	2.3	2.3
Age started oral contraceptive pill	1.8	2.3	4.6	-1.0	1.7	-0.8	-1.1	-2.2	-1.9	-1.4	-1.7	-1.8	-1.3	-0.9
Diastolic blood pressure, automated reading	1.8	5.5	8.8	2.8	-0.2	1.7	2.2	2.6	2.9	3.0	2.2	2.3	2.1	2.4
Reaction Time	1.7	3.2	8.5	-0.5	-1.2	2.5	0.4	0.4	1.3	1.8	2.2	2.7	2.9	1.0
Body Mass Index (BMI) (2010)	1.7	2.4	4.7	-1.8	0.1	-0.9	-2.2	-1.8	-1.8	-1.7	-1.6	-1.1	-1.1	-1.8
LDL Cholesterol	1.7	2.6	8.5	-1.5	0.1	-1.4	-1.5	-2.2	-1.6	-1.8	-0.9	-1.1	-1.3	-2.9
BMI	1.7	9.6	24.4	-3.7	1.1	-1.9	-2.9	-4.9	-3.8	-3.8	-2.0	-1.8	-1.7	-4.0
Illnesses of father: None of the above (group 1)	1.7	2.1	4.5	-0.0	-0.1	-1.9	-1.8	-0.9	-1.4	-0.7	-2.1	-1.6	-1.9	-1.4
Neuroticism (2016)	1.6	2.3	7.1	2.4	0.2	-0.5	1.5	2.7	1.7	2.1	0.1	-0.1	-0.3	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	10.0	3.2	-1.5	1.2	2.1	2.0	2.0	1.5	2.3	1.8	1.3	0.7
Qualifications: CSEs or equivalent	1.6	2.1	4.3	0.1	0.6	-1.9	-1.2	-0.7	-1.5	-1.2	-1.9	-1.8	-2.1	-1.4
Time employed in main current job	1.6	1.8	3.2	-1.3	1.4	-1.8	-1.2	-1.4	-1.4	-1.4	-0.9	-1.1	-1.3	-1.6
Number of live births	1.6	2.3	3.9	0.6	0.4	-1.9	-0.7	-1.8	-1.8	-1.3	-2.0	-2.0	-1.7	-1.4
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.9	-1.1	0.1	-1.3	-1.4	-0.4	-1.3	-1.5	-1.6	-1.4	-2.0	-1.7
Depression (Nagel 2018)	1.5	2.3	4.9	0.7	0.2	1.2	1.2	1.7	1.8	1.9	1.5	1.4	1.7	2.2
Neuroticism (Nagel 2018)	1.5	3.6	8.9	2.4	3.0	0.8	1.7	2.1	1.5	1.9	1.1	0.7	1.5	2.8
Blood White Count	1.5	11.4	26.9	1.7	-0.7	4.3	0.5	2.4	3.4	3.9	3.6	5.1	5.2	2.4
Neuroticism	1.5	3.7	7.8	2.8	1.7	0.8	2.1	2.4	1.8	2.1	1.4	0.7	1.4	2.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	6.0	-2.5	-0.5	-1.5	-1.6	-1.2	-1.2	-0.9	-1.5	-1.4	-1.5	-0.7
Medication: Simvastatin	1.5	2.2	9.2	-1.9	0.0	-0.6	-2.0	-2.0	-1.1	-1.0	-0.6	0.2	-0.6	-3.0
Lung cancer (father)	1.5	1.7	8.8	-0.4	0.0	-0.3	-1.3	-1.1	-1.1	-0.9	-1.4	-0.7	-1.4	-3.0
Mean time to correctly identify matches	1.5	2.9	6.8	-1.0	-1.8	2.6	0.5	0.5	1.3	1.4	2.0	2.4	2.5	0.6
Commuting to job workplace: Public transport	1.5	1.8	3.2	1.8	-1.5	0.5	1.1	1.7	1.6	1.6	0.9	1.1	0.7	1.3
High cholesterol (Self-reported)	1.5	2.6	9.7	-3.1	-0.0	-0.8	-2.2	-1.8	-1.2	-1.0	-1.0	-0.3	-0.8	-2.6
Worry (Nagel 2018)	1.4	2.9	7.2	2.3	2.7	0.7	1.5	2.5	1.3	1.6	0.2	-0.1	0.4	2.5
Hair/balding pattern: Pattern 2	1.4	1.8	3.7	-0.4	1.9	-1.7	-1.6	-1.1	-1.4	-1.4	-1.3	-1.1	-1.1	-0.9
Pain all over the body in last month	1.4	1.5	6.7	-2.6	-0.7	-0.3	0.3	-1.6	-1.2	-1.7	-0.2	-1.0	-0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	8.6	-1.2	2.9	-1.4	-1.4	-0.8	-1.3	-0.6	-1.1	-0.5	-0.4	-0.4
Eye problems/disorders: None of the above	1.4	1.7	5.3	-0.7	-0.4	-1.3	-1.2	-1.1	-1.2	-1.6	-0.9	-0.9	-1.5	-2.3
Medication: Lansoprazole	1.3	1.5	5.2	-1.1	0.2	-0.5	-2.3	-0.7	-1.1	-0.5	-1.6	-0.3	-1.0	-2.0
Breastfed as a baby	1.3	1.6	4.1	-1.3	1.7	-1.1	-1.6	-2.0	-1.4	-1.3	-0.3	-0.1	0.1	-1.3
Medication: Aspirin	1.3	1.7	5.8	-1.2	1.2	-0.5	-2.3	-1.5	-0.9	-0.3	-0.6	0.9	0.2	-2.4
Number of incorrect matches in round	1.2	1.9	4.1	-2.0	0.6	-1.0	-1.3	-1.5	-1.5	-1.6	-1.4	-1.3	-1.2	-1.3
Hip circumference	1.2	5.3	10.3	-1.7	1.3	-2.2	-1.8	-3.2	-3.2	-2.7	-2.1	-2.2	-1.9	-2.4
Crohns Disease (2017)	1.1	2.5	7.3	-0.2	-1.5	2.7	0.1	1.3	1.8	1.5	1.3	2.1	1.7	1.1
Lupus	1.1	1.7	7.8	2.8	-0.1	0.3	1.5	1.5	1.1	1.7	0.3	0.4	0.2	1.1
Diabetes (father)	1.1	1.4	2.7	-1.4	0.2	1.3	0.5	0.6	1.2	0.8	1.6	1.3	1.6	1.3
Stomach or abdominal pain in last month	1.1	1.4	3.6	-0.2	0.6	1.5	0.5	0.4	0.9	1.1	1.4	1.6	1.9	1.5
Exposure to tobacco smoke at home	1.1	1.3	3.4	-1.5	-0.7	0.3	-1.3	-1.8	-1.2	-1.0	-0.5	-0.0	0.1	-1.8
Loud music exposure frequency	1.1	1.2	6.1	0.3	0.0	0.4	1.7	1.1	0.6	1.2	0.3	-0.4	0.6	2.5
Arm fat-free mass (right)	1.1	5.7	13.7	-1.6	0.9	-2.5	-1.2	-3.7	-3.2	-3.2	-1.7	-2.3	-2.0	-2.5
Number of children fathered	1.1	1.3	3.6	-1.9	-0.4	-1.1	-1.2	-0.1	-0.6	-1.1	-1.4	-1.2	-1.5	-0.7
Shortness of breath walking on level ground	1.1	1.4	3.1	-0.8	-0.7	-1.2	-0.4	-1.4	-1.2	-1.6	-0.8	-0.9	-1.3	-1.8
Medication: Aspirin	1.1	1.5	5.7	-1.1	1.2	-0.4	-2.2	-1.3	-0.8	-0.3	-0.5	0.9	0.3	-2.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.8	1.1	-0.6	2.2	1.0	0.8	1.4	1.1	1.7	1.6	1.5	0.1
Arm fat-free mass (left)	1.1	5.6	13.8	-1.5	1.1	-2.3	-1.3	-3.7	-3.2	-3.2	-1.7	-2.2	-1.8	-2.3
Unable to work because of sickness or disability	1.1	1.5	4.0	-1.3	-0.9	1.5	0.5	-0.5	0.9	0.6	1.7	2.0	1.6	-0.3
Alzheimer’s Disease (in mother)	1.0	1.2	3.3	-0.4	-0.2	-1.3	-1.2	-0.4	-1.1	-1.1	-1.2	-1.0	-1.4	-1.8
Irritable Bowel Disease (IBD)	1.0	2.3	7.7	-0.1	-1.4	2.8	-0.1	1.5	1.7	1.7	0.8	1.8	1.4	1.0
Systolic blood pressure, automated reading	1.0	3.0	7.4	1.6	-0.3	1.6	0.4	1.9	2.0	2.7	1.3	2.4	2.1	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.6	-1.9	-0.8	-0.5	-0.8	-0.9	-0.6	-1.2	-0.9	-1.1	-1.3	-1.0
Waist circumference	1.0	3.8	9.9	-2.1	-0.3	-1.3	-1.2	-3.1	-2.3	-2.3	-1.3	-1.4	-1.4	-2.8
Had menopause	1.0	1.3	3.2	-0.9	0.0	-1.2	-0.2	-1.8	-1.2	-1.5	-0.6	-0.9	-1.1	-1.6
Allergy	1.0	2.4	4.7	1.4	0.7	1.5	0.8	1.3	1.5	1.5	1.9	2.0	2.2	1.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.1	-0.3	1.6	-0.9	-1.3	-2.0	-1.2	-0.8	-0.5	-0.5	-0.5	-1.6
Arm predicted mass (right)	1.0	5.3	12.6	-1.4	0.8	-2.4	-1.1	-3.6	-3.0	-3.1	-1.6	-2.2	-2.0	-2.5
Alcohol intake frequency.	1.0	2.4	5.4	-0.1	-1.4	2.3	1.3	1.7	1.8	1.3	1.5	1.6	1.7	1.4
Wears glasses or contact lenses	1.0	1.1	3.4	0.6	1.4	-1.8	-0.3	-0.6	-0.8	-1.0	-0.8	-1.3	-1.4	-0.4
Alcohol drinker status: Never	1.0	1.1	2.8	0.7	-0.0	1.0	1.1	1.5	1.5	1.7	0.7	0.5	0.5	1.2
Fasting Glucose	0.9	1.1	2.7	-0.8	-0.5	-0.7	-1.7	-0.5	-1.1	-1.1	-1.0	-0.5	-1.0	-1.7
Hearing difficulty/problems: Yes	0.9	1.4	3.1	-0.7	1.1	-0.1	-1.1	-1.6	-1.6	-1.8	-1.1	-1.0	-0.8	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.2	-0.6	-1.2	-0.0	-0.4	-1.3	-1.3	-1.5	-0.9	-1.1	-0.9	-1.0
Weight	0.9	4.7	11.9	-1.9	0.7	-1.9	-1.1	-3.5	-3.0	-2.9	-1.5	-2.0	-1.6	-2.1
Impedance of arm (right)	0.9	4.2	12.3	1.9	-0.9	2.0	2.2	2.7	2.1	1.8	1.6	0.8	1.5	3.5
Father’s age at death	0.9	1.2	6.9	1.5	0.2	-0.1	0.7	1.5	0.2	0.9	-0.4	-0.8	-0.0	2.6
Pulse rate	0.9	1.5	3.6	0.6	1.0	1.2	1.1	-0.8	0.9	0.7	1.9	1.8	1.9	0.2
Pulse rate, automated reading	0.9	2.8	6.2	0.7	1.8	1.9	1.5	-0.1	1.3	1.1	2.3	2.3	2.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.6	-0.9	0.8	-1.9	-1.3	-1.4	-1.8	-1.6	-1.3	-1.6	-1.2	-0.4
Mood swings	0.9	1.7	6.1	1.2	0.2	0.2	1.6	2.5	1.4	1.5	0.8	0.4	0.3	1.7
Medication: Gliclazide	0.9	1.0	2.4	-0.6	0.1	0.5	0.5	0.2	0.9	1.1	1.5	1.5	1.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	7.0	1.4	0.5	0.9	0.5	2.6	1.3	1.7	0.1	0.3	0.6	2.5
Hearing aid user	0.9	1.0	2.3	0.9	0.2	1.4	1.0	0.5	0.9	0.3	1.5	1.3	1.3	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.8	0.4	-1.7	1.2	-0.0	1.6	1.4	1.1	0.2	0.6	0.4	0.6
Alcohol drinker status: Previous	0.9	1.1	2.9	-0.1	-0.8	0.9	1.7	0.3	0.9	0.9	1.3	1.0	1.4	0.9
Depressed Affect (Nagel 2018)	0.8	1.7	4.6	0.7	2.1	0.4	1.4	1.1	0.9	1.2	1.3	0.7	1.3	2.1
Crohns Disease (2012)	0.8	1.3	4.3	0.3	-1.2	1.2	0.5	2.1	1.6	1.2	0.8	1.3	0.3	-0.0
Systolic Blood Pressure	0.8	4.2	7.7	1.9	-0.1	1.6	0.7	2.7	2.6	2.8	1.9	2.6	2.1	1.6
Average weekly spirits intake	0.8	1.0	2.0	0.2	1.1	-1.3	-1.3	-0.8	-1.4	-0.7	-1.4	-0.9	-0.7	-0.2
Supplements: Zinc	0.8	0.8	1.6	-1.0	-0.9	1.3	-0.4	0.6	1.0	1.0	0.7	1.2	1.2	0.6
Severe depression (siblings)	0.8	0.9	2.4	-0.7	0.3	0.7	0.8	0.6	0.7	1.0	1.1	0.9	1.5	1.6
Hand grip strength (right)	0.8	2.2	5.3	-0.5	-0.1	-1.6	0.0	-2.0	-1.9	-2.3	-1.1	-2.2	-1.4	0.1
Trunk fat mass	0.8	3.3	8.0	-2.1	0.1	-1.3	-1.1	-2.8	-2.5	-2.4	-1.2	-1.6	-1.2	-1.9
Hearing difficulty/problems with background noise	0.8	1.3	2.2	-0.6	1.1	-0.6	-1.1	-1.0	-1.3	-1.1	-1.4	-1.5	-1.4	-1.3
Neuroticism score	0.8	1.6	3.9	1.9	1.1	-0.1	1.6	2.0	1.0	1.3	0.2	-0.5	0.0	1.8
Impedance of arm (left)	0.8	3.5	9.5	2.2	-0.9	1.3	2.4	2.5	1.9	1.8	1.4	0.4	1.1	3.1
Illnesses of siblings: Diabetes	0.8	0.9	4.9	-2.2	0.6	0.1	-1.1	-0.8	-0.1	-0.2	0.8	1.1	0.6	-1.1
Whole body fat-free mass	0.8	4.4	11.2	-1.0	1.0	-2.2	-0.7	-3.3	-2.9	-2.9	-1.4	-2.3	-1.8	-1.7
Average weekly champagne plus white wine intake	0.8	1.1	3.9	-0.1	-1.8	0.5	-0.2	-2.0	-0.8	-1.3	-0.0	-0.2	-0.0	-1.3
Basal metabolic rate	0.8	4.2	10.7	-1.2	0.8	-2.1	-0.7	-3.3	-2.8	-2.8	-1.4	-2.2	-1.7	-1.7
Ever depressed for a whole week	0.8	1.0	3.0	1.2	-0.2	0.8	1.7	1.2	1.0	0.4	1.3	0.6	0.7	1.1
Arm predicted mass (left)	0.8	4.1	11.2	-1.3	0.7	-1.8	-1.1	-3.4	-2.7	-2.8	-1.2	-1.7	-1.4	-2.3
Coronary Artery Disease (CAD)	0.7	0.8	3.2	1.8	0.2	-0.4	-0.3	-0.1	-0.7	-0.5	-1.4	-0.7	-1.0	-1.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.6	-0.6	1.3	0.7	1.3	-1.6	-0.9	-1.1	0.4	-0.6	0.6	0.5
Leg fat-free mass (left)	0.7	3.5	8.4	-1.0	0.9	-2.1	-0.3	-2.9	-2.5	-2.5	-1.2	-2.3	-1.7	-1.2
Leg predicted mass (left)	0.7	3.7	9.1	-1.0	0.8	-2.1	-0.2	-3.0	-2.6	-2.6	-1.3	-2.3	-1.8	-1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	0.2	0.4	1.3	1.1	0.4	0.7	0.6	1.1	0.7	1.2	1.3
Mouth/teeth dental problems	0.7	1.1	4.1	-0.4	-1.0	-0.8	1.3	1.5	0.3	0.0	-0.4	-1.2	-0.7	2.0
Trunk fat-free mass	0.7	3.8	10.5	-0.8	1.1	-1.9	-0.7	-3.2	-2.7	-2.8	-1.2	-2.0	-1.5	-1.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.7	1.3	1.5	0.7	1.1	1.3	1.5	1.6	1.3	1.0	1.0	1.3
Mouth/teeth dental problems: Dentures	0.7	1.2	4.4	-0.8	-0.4	0.9	-1.9	-0.9	-0.2	0.2	0.1	1.5	0.7	-2.1
Pulse wave reflection index	0.7	0.9	2.3	-0.2	1.5	-1.3	-0.9	0.1	-0.8	-0.8	-1.0	-1.2	-1.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	1.8	0.1	0.8	1.5	0.6	1.0	1.0	1.3	0.9	0.9	0.6
Whole body fat mass	0.7	3.0	7.3	-2.0	0.2	-1.2	-1.1	-2.7	-2.4	-2.2	-1.3	-1.5	-1.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	-1.2	-0.9	-1.3	0.4	-0.6	-0.6	-0.9	-0.7	-1.0	-1.0	-1.1
Leg fat-free mass (right)	0.7	3.8	7.5	-0.6	0.9	-2.5	-0.3	-2.7	-2.6	-2.3	-1.5	-2.5	-2.1	-1.3
Whole body water mass	0.7	4.2	10.5	-0.9	1.0	-2.2	-0.6	-3.2	-2.8	-2.8	-1.4	-2.2	-1.7	-1.6
Leg predicted mass (right)	0.7	3.8	7.7	-0.6	1.0	-2.5	-0.3	-2.8	-2.6	-2.3	-1.5	-2.5	-2.0	-1.3
Financial situation satisfaction	0.7	0.9	2.2	0.6	-0.9	-1.0	0.2	-0.7	-0.8	-0.8	-1.1	-1.5	-1.4	-0.3
Eye problems/disorders: Glaucoma	0.7	0.9	3.1	1.0	-0.1	-0.5	0.5	1.8	0.7	1.0	-0.6	-0.7	-0.7	1.4
Risk taking	0.7	1.0	4.0	-1.2	2.0	-1.0	0.1	-1.2	-1.0	-1.0	0.0	-0.5	0.1	0.5
Impedance of whole body	0.7	3.6	7.2	1.7	-1.5	2.0	1.8	2.7	2.1	1.7	1.6	1.2	1.6	2.4
Alzheimer’s Disease (in father)	0.6	0.7	2.6	0.5	-0.7	1.2	0.5	1.6	0.7	0.9	-0.1	0.3	0.4	0.9
Major Depression (MDD)	0.6	0.8	2.6	1.4	-0.6	0.2	1.6	0.9	0.7	0.4	0.6	-0.4	0.0	1.2
HbA1C	0.6	0.7	2.5	-0.3	-0.4	0.1	-0.7	-1.6	-0.7	-0.8	0.3	0.6	0.3	-1.6
Ulcerative Colitis	0.6	0.8	3.4	1.2	0.3	0.9	-0.2	1.8	0.9	1.4	-0.4	0.7	0.2	0.1
Angina	0.6	0.8	2.5	0.8	-0.6	0.8	0.2	0.6	0.9	1.2	0.7	1.6	0.9	-0.7
Vitamin and mineral supplements	0.6	0.8	1.8	-0.7	-0.7	-0.8	-0.4	-0.8	-0.9	-1.1	-0.9	-1.4	-1.2	-0.4
Age when periods started (menarche)	0.6	1.4	3.9	-2.0	0.7	0.9	-1.3	-1.7	-0.7	-0.7	0.4	1.0	1.4	-1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	1.0	0.0	1.1	0.9	-0.4	0.3	-0.1	1.4	1.2	1.1	-0.1
Body mass index (BMI)	0.6	2.5	6.0	-2.3	0.3	-0.8	-1.3	-2.4	-1.8	-1.6	-1.1	-0.7	-0.8	-2.3
Nervous feelings	0.6	1.2	3.2	1.8	1.7	-0.1	1.0	1.5	0.4	0.4	-0.6	-1.1	-0.8	1.1
Heart attack	0.6	0.8	2.6	0.6	-0.3	1.1	0.2	0.3	0.7	1.2	0.8	1.6	1.4	-0.3
Medication: Cholesterol lowering	0.6	1.0	5.0	-0.3	0.9	-0.9	-2.2	-0.2	-0.1	0.8	-0.6	0.7	-0.2	-1.7
Depression (self-reported)	0.6	0.7	2.2	-0.3	0.5	-1.0	-0.7	-1.4	-0.8	-1.0	-0.2	-0.4	-0.6	-1.5
Arm fat mass (right)	0.6	2.6	6.1	-2.1	0.1	-1.0	-0.8	-2.5	-2.1	-2.0	-1.2	-1.5	-1.2	-1.7
Trunk predicted mass	0.6	3.6	10.2	-0.8	1.1	-1.9	-0.6	-3.2	-2.6	-2.8	-1.1	-2.0	-1.4	-1.5
Headache pain in last month	0.6	1.1	1.8	-1.3	1.2	-1.3	0.4	-1.3	-1.1	-0.9	-0.6	-1.3	-0.8	-0.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.3	-0.4	-1.8	1.1	1.7	-0.8	0.0	-1.4	0.8	-0.5	-0.0	-0.1
Leg fat percentage (right)	0.6	2.0	6.9	-2.6	0.6	-0.2	-1.2	-1.9	-1.6	-1.6	-0.7	-0.4	-0.4	-1.9
Angina (self-reported)	0.6	0.8	2.6	0.9	-0.4	0.8	0.4	0.4	1.0	1.1	1.0	1.6	1.0	-0.7
Leg fat mass (right)	0.6	2.2	5.9	-2.2	0.5	-0.6	-0.9	-2.4	-2.0	-2.0	-0.8	-0.9	-0.7	-1.6
Family relationship satisfaction	0.6	0.7	2.7	0.6	1.6	-0.9	-1.3	0.3	-0.6	0.0	-1.0	-0.7	-0.4	0.6
Long-standing illness, disability or infirmity	0.6	0.9	2.4	-1.5	-0.5	1.5	0.9	-1.0	-0.1	-0.5	1.0	0.4	1.1	0.4
Qualifications: nursing, teaching	0.6	1.0	2.5	1.1	1.2	0.0	1.2	1.3	1.1	1.0	0.6	0.3	0.3	1.6
Arm fat mass (left)	0.6	2.5	6.4	-2.2	0.3	-1.0	-0.7	-2.5	-2.1	-2.0	-1.0	-1.3	-1.1	-1.7
Medication: Lisinopril	0.6	0.8	2.3	-0.6	-1.1	1.0	-0.2	1.5	1.1	1.0	0.3	0.9	0.6	0.9
Cholesterol lowering medication	0.6	0.9	2.7	-1.5	-1.6	1.2	0.0	-0.9	-0.0	-0.5	0.4	0.8	0.5	-1.3
Schizophrenia vs Biploar Disorder	0.5	0.7	2.3	0.8	-0.1	0.5	-0.9	0.7	0.7	1.1	0.3	1.5	0.9	-0.6
Primary Biliary Cirrhosis	0.5	0.7	2.9	1.7	1.1	-1.0	-0.5	0.3	-0.3	0.6	-0.9	-0.4	-0.5	-0.0
Height	0.5	9.5	22.6	-0.4	2.4	-3.2	-0.0	-4.3	-4.3	-4.4	-2.1	-4.8	-2.3	0.3
Impedance of leg (right)	0.5	2.6	6.9	0.3	-1.4	2.6	0.5	1.7	1.7	1.0	1.7	1.9	2.1	1.2
Trunk fat percentage	0.5	2.0	4.6	-1.8	-0.5	-0.7	-0.8	-2.1	-1.9	-1.7	-0.9	-1.0	-0.8	-1.7
Townsend deprivation index at recruitment	0.5	0.7	2.6	-1.4	-0.4	-0.5	-1.0	-0.7	-0.5	-1.0	-0.3	0.0	-0.6	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	-0.6	-1.0	0.7	0.8	0.7	0.9	0.8	0.8	0.5	0.7	1.0
Taking other prescription medications	0.5	0.7	2.6	-1.4	0.2	0.1	-0.6	-1.6	-0.9	-1.2	0.0	-0.2	0.0	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-0.6	0.2	1.0	-0.8	0.4	0.5	0.8	0.6	1.2	1.2	0.4
Medication: Ramipril	0.5	0.7	1.9	1.1	0.7	0.1	0.5	1.0	0.8	1.4	0.4	0.9	0.6	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-1.0	-1.1	-0.4	-0.7	-1.2	-0.7	-0.9	-0.2	-0.2	-0.2	-1.0
Glaucoma (self-reported)	0.5	0.6	1.9	0.7	-0.0	-0.2	-0.1	1.4	0.4	0.8	-0.7	-0.6	-0.5	1.4
Birth weight	0.5	1.1	2.6	-0.1	0.7	0.8	1.2	-1.6	-1.2	-1.5	0.5	-1.0	0.4	1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.3	0.1	-1.5	1.1	0.2	-0.9	0.2	0.4	0.5	1.0	1.0	-0.5
Neck or shoulder pain in last month	0.5	0.8	1.9	-1.4	1.2	-0.7	-1.0	-0.7	-0.9	-0.7	-1.0	-0.9	-0.4	0.1
Medication: Blood pressure	0.5	0.8	3.7	0.8	1.9	-0.9	-1.3	0.4	-0.4	1.0	-0.5	0.5	0.2	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.3	-0.2	0.8	-0.8	-1.0	-0.8	-0.7	-0.4	-0.2	0.2	-0.4	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	1.2	0.6	0.4	0.3	1.1	0.9	1.2	0.3	0.7	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	2.5	-0.5	-0.9	0.1	-0.9	-0.5	-0.7	-0.4	-0.8	0.1	-0.3	-1.6
Osteoporosis (self-reported)	0.5	0.6	2.9	1.3	1.7	-0.5	0.3	-0.0	-0.4	0.1	-0.5	-0.7	-0.3	0.9
Leg fat percentage (left)	0.5	1.7	4.8	-2.2	0.5	-0.5	-1.3	-1.6	-1.5	-1.3	-0.9	-0.4	-0.6	-1.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.0	0.5	-0.4	0.8	-0.1	0.2	0.6	1.1	0.6	1.4	1.1	-0.4
Leg fat mass (left)	0.5	2.1	5.0	-2.0	0.5	-0.9	-0.9	-2.2	-2.0	-1.9	-1.0	-1.1	-0.9	-1.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	-0.2	-1.1	-0.5	-0.6	0.3	-0.4	-0.6	-0.7	-0.6	-1.1	-1.2
Blood Red Count	0.4	3.7	13.5	0.2	3.7	-0.1	0.5	-2.5	-1.1	-1.3	2.2	0.5	2.6	2.5
Waist Hip Ratio (WHR)	0.4	1.7	5.7	-1.4	-2.3	1.1	-0.4	-1.4	0.2	-0.3	0.6	1.2	0.6	-2.4
Cardiovascular Disease	0.4	1.3	3.8	-1.3	1.7	-0.7	-1.9	-0.8	-0.5	0.4	-0.6	0.8	0.1	-1.7
Lung FVC	0.4	1.9	4.8	1.4	0.3	-0.8	-0.1	1.5	-0.5	-0.0	-2.1	-2.1	-1.5	2.2
Average weekly fortified wine intake	0.4	0.5	1.5	0.2	-0.5	-0.5	0.6	-0.9	-1.0	-1.2	-0.1	-0.8	-0.6	-0.3
Fed-up feelings	0.4	0.7	2.1	-0.2	0.2	0.2	0.5	1.4	1.0	1.5	0.6	0.6	0.5	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.8	0.3	0.0	0.1	0.0	1.3	0.8	1.4	-0.5	0.0	-0.0	0.6
Supplements: Glucosamine	0.4	0.6	1.5	0.7	1.2	-1.2	0.2	-0.6	-0.7	-0.4	-0.5	-0.3	-0.6	-1.1
Sitting height	0.4	2.8	6.9	0.9	0.6	-2.0	0.3	-2.2	-2.0	-2.3	-1.2	-2.6	-1.8	-0.6
Impedance of leg (left)	0.4	2.2	4.1	1.0	-1.5	2.0	0.5	1.9	1.6	1.3	1.3	1.7	1.6	1.1
Alcohol usually taken with meals	0.4	0.6	1.8	-0.3	0.6	1.0	0.9	-0.9	-0.1	0.1	1.0	0.7	1.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	7.0	2.6	-0.6	-0.2	0.8	0.3	0.3	0.1	0.7	0.2	-0.1	-0.4
Financial difficulties in last 2 years	0.4	0.6	2.9	0.9	-1.7	0.4	0.7	0.5	0.9	0.5	0.4	0.5	-0.1	-0.8
Illnesses of siblings	0.4	0.5	2.6	0.5	-1.6	0.2	0.5	0.5	0.5	0.2	0.9	0.3	0.5	0.9
Standing height	0.4	3.8	9.5	0.5	0.9	-2.1	0.2	-2.9	-2.8	-3.1	-0.9	-2.7	-1.3	-0.1
Length of working week for main job	0.4	0.4	1.2	-1.0	-1.1	0.0	0.1	-1.1	-0.2	-0.6	0.4	0.2	0.1	-0.6
Body fat percentage	0.4	1.5	3.3	-1.8	-0.2	-0.5	-0.9	-1.8	-1.7	-1.5	-0.9	-0.8	-0.7	-1.6
Comparative body size at age 10	0.4	1.1	3.6	-1.1	-1.9	1.4	-0.3	0.6	1.0	0.5	0.7	1.4	0.9	-0.4
Worry too long after embarrassment	0.4	0.6	3.8	2.0	0.4	0.0	1.1	0.6	0.2	0.3	0.4	-0.4	0.0	0.9
Age at first live birth	0.4	0.7	2.4	0.8	0.2	-0.6	0.5	1.5	0.8	1.5	0.2	0.5	-0.1	0.6
Qualifications: College or University degree	0.4	1.3	4.3	1.0	2.1	0.5	1.0	0.7	0.8	0.6	1.1	0.6	1.1	1.9
Comparative height size at age 10	0.4	1.9	5.6	-0.1	0.4	-1.5	-0.5	-2.4	-2.0	-2.1	-0.9	-1.8	-0.9	-0.2
Had major operations	0.4	0.5	1.7	-1.3	1.2	-0.4	-0.9	-0.8	-0.4	-0.2	-0.3	0.0	-0.0	-0.4
Age at last live birth	0.4	0.6	2.5	0.6	0.2	-0.1	0.2	1.4	0.8	1.6	-0.1	0.5	0.1	0.5
Supplements: Vitamin C	0.4	0.5	3.1	0.1	1.8	0.6	-0.2	0.6	0.5	0.7	0.0	0.3	0.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	0.8	-0.8	0.6	1.1	-1.1	-0.0	-0.5	0.3	-0.5	0.2	0.0
Eye problems/disorders: Cataract	0.4	0.5	1.5	0.7	-0.2	1.2	1.2	0.1	0.6	0.1	0.9	0.6	0.7	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	-0.0	1.2	-0.3	-0.2	-1.2	-0.7	-0.7	-0.6	-0.8	-0.3	-0.0
Illnesses of father: High blood pressure	0.4	0.4	2.5	-0.9	1.6	0.0	-0.9	-0.2	-0.3	0.3	-0.1	0.5	0.5	-0.2
Myopia	0.4	0.6	2.1	1.4	-1.5	-0.9	0.8	0.5	0.4	0.0	-0.1	-0.5	-0.8	-0.3
Heart disease (siblings)	0.4	0.5	1.3	1.1	0.7	0.2	0.8	1.1	0.7	0.9	0.1	0.4	0.0	0.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.5	1.4	-0.1	0.7	-1.1	0.0	0.2	1.2	0.5	1.9	1.6	0.0
Ulcerative Colitis (UC)	0.3	0.6	2.5	0.0	-0.7	1.6	-0.2	0.9	0.8	1.1	-0.1	0.8	0.4	0.3
HDL Cholesterol	0.3	0.5	2.3	1.5	-1.0	-1.2	0.7	0.1	-0.1	-0.0	0.1	-0.1	-0.4	-0.2
Triglycerides	0.3	0.5	0.9	-0.7	0.7	-0.4	-0.8	-0.8	-0.9	-0.7	-0.9	-0.8	-0.5	-0.6
Blood Platelet Count	0.3	3.3	10.2	-0.3	1.6	-1.3	-0.3	-3.0	-1.7	-1.9	-1.3	-1.3	-1.7	-3.2
Smoking Status	0.3	0.6	1.5	-0.5	-1.1	1.2	-0.9	-0.5	-0.4	-0.0	-0.1	0.4	1.2	1.2
Allergy or Eczema	0.3	0.7	2.0	0.4	-1.2	0.8	0.3	1.4	0.9	1.4	0.1	0.4	0.4	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.8	-0.7	-0.2	-0.4	-1.1	-1.4	-0.6	-0.1	-0.1	0.5	0.3	-1.4
Relative age of first facial hair	0.3	0.7	5.7	-2.4	0.0	0.5	-0.7	-0.2	-0.3	-0.2	-0.1	0.4	0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.0	0.7	-0.0	-0.6	-0.3	-0.7	-0.6	-0.7	-0.0	0.2	-0.2	-1.0
Had other major operations	0.3	0.4	1.6	0.4	0.5	-0.8	0.6	0.5	-0.3	0.3	-0.5	-1.0	-0.3	1.3
Qualifications: None of the above	0.3	0.7	1.8	-0.6	-0.8	1.3	0.4	0.3	0.4	0.2	1.0	0.9	1.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.5	-0.4	-1.2	0.6	0.2	1.0	0.7	0.7	0.2	0.0	0.2	0.7
Falls in the last year	0.3	0.4	0.9	0.8	-0.7	0.6	0.5	-0.2	0.2	0.2	0.7	0.9	1.0	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.7	2.2	-0.5	0.2	1.0	1.4	0.4	0.4	-0.1	-0.4	-0.3	1.7
Prospective memory result	0.3	0.4	1.0	-0.5	-0.4	1.0	0.3	0.8	0.5	0.4	0.5	0.6	0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.5	2.1	-0.6	-0.0	0.6	1.5	0.4	0.2	-0.3	-0.5	-0.6	1.0
Tense / ‘highly strung’	0.3	0.4	2.1	-0.3	1.4	-0.7	-1.0	0.3	-0.4	-0.1	-0.5	-0.4	-0.0	0.3
Peak expiratory flow (PEF)	0.3	0.7	1.5	0.1	0.8	-0.1	-0.4	-0.5	-1.0	-1.2	-1.1	-1.1	-1.1	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.1	2.4	1.2	0.6	-1.2	-0.4	-0.5	-1.2	-1.3	-1.1	-1.5	-1.2	0.2
Exposure to tobacco smoke outside home	0.3	0.4	2.1	1.5	-0.7	0.5	0.8	-0.4	0.3	0.2	0.4	0.4	0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	1.0	0.4	-0.5	0.2	0.5	-0.1	0.6	-0.8	-0.5	-0.5	0.6
Health satisfaction	0.3	0.5	2.4	-0.1	-1.6	-0.1	0.6	0.6	-0.0	0.0	-0.4	-0.8	-0.7	0.7
Suffer from ‘nerves’	0.3	0.4	1.3	0.2	0.7	0.1	0.0	0.9	0.0	0.2	-1.0	-1.1	-0.9	0.1
Overall health rating	0.3	0.7	2.7	-1.5	-0.4	0.3	-0.1	-1.6	-1.0	-1.2	0.1	-0.5	0.1	-0.5
Illnesses of father: Heart disease	0.3	0.4	1.4	-0.4	-0.6	1.2	0.6	0.7	0.9	0.3	0.5	0.3	0.3	0.4
Diabetes diagnosed by doctor	0.3	0.4	1.1	-1.1	-0.3	0.1	-1.0	-1.0	-0.3	-0.2	0.3	0.7	0.7	-0.6
Friendships satisfaction	0.3	0.4	2.0	1.4	0.2	0.6	0.0	0.9	0.3	0.4	-0.2	-0.2	0.2	1.1
Medication for cholesterol	0.3	0.5	2.2	1.5	1.3	-0.9	-0.4	0.1	-0.0	0.6	-0.1	-0.0	-0.2	-0.0
Mineral and other dietary supplements	0.3	0.4	1.2	0.3	-1.1	0.5	0.7	0.4	1.0	0.4	0.8	0.5	0.3	0.3
Osteoarthritis (self-reported)	0.3	0.4	1.2	0.6	1.1	0.8	0.1	0.5	0.5	0.3	0.8	0.9	0.7	0.2
Guilty feelings	0.3	0.5	1.3	0.6	1.1	-0.9	0.3	-1.2	-0.9	-0.1	-0.2	-0.7	-0.0	0.1
Mother’s age at death	0.3	0.3	1.1	-0.2	1.0	-0.7	-0.4	-0.9	-0.7	-0.7	0.1	0.1	-0.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-0.3	1.1	-0.1	-0.9	-0.1	-0.6	0.0	-1.1	-0.6	-0.5	-0.2
Medication: Bendroflumethiazide	0.3	0.4	1.6	0.8	0.4	0.4	0.1	0.7	0.6	1.3	0.0	0.6	0.4	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.8	-0.2	0.1	-0.3	0.6	-1.1	-1.0	-1.4	-0.6	-1.7	-0.7	0.5
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.8	0.6	0.9	-0.3	-0.2	-0.5	-0.0	-0.7	-0.9	-0.1	0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.6	-0.2	1.3	0.8	-0.3	0.1	-0.2	0.3	-0.4	-0.5	0.3	1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	1.0	1.2	-0.2	-0.7	-0.3	-0.4	0.1	0.1	0.8	0.7	-0.1
Age at First Birth	0.2	0.3	0.9	0.2	0.1	0.9	-0.2	0.3	0.5	0.7	0.3	1.0	0.9	0.2
Hand grip strength (left)	0.2	0.4	1.5	-0.1	-0.1	-0.5	0.1	-0.9	-0.9	-1.2	-0.1	-0.8	-0.0	0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	-0.1	0.3	-0.1	0.1	0.8	0.6	0.9	0.4	0.5	0.5	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.9	0.1	-0.7	0.9	0.6	-0.1	0.0	-0.2	0.5	0.1	0.5	0.5
Relative age voice broke	0.2	0.2	1.7	-1.3	0.1	0.1	-0.6	0.2	0.3	0.0	0.3	0.5	0.3	-0.3
Medication: Atenolol	0.2	0.3	1.2	0.6	-0.7	-0.2	0.2	1.1	0.7	0.7	0.4	0.5	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	1.0	-0.2	0.8	-1.0	-0.4	-0.6	-0.4	-0.2	-0.2	-0.3	-0.2	-0.3
Forced vital capacity (FVC)	0.2	0.8	1.8	1.0	0.6	-0.9	-0.1	-0.6	-1.2	-1.1	-0.9	-1.4	-0.8	0.8
Diabetes (self-reported)	0.2	0.4	1.1	-0.4	0.2	-0.5	-1.0	-1.0	-0.8	-0.2	-0.4	0.0	-0.1	-0.7
Arm fat percentage (right)	0.2	0.8	3.6	-1.9	0.2	-0.2	-0.5	-1.2	-1.1	-1.0	-0.6	-0.7	-0.5	-0.7
Illnesses of mother	0.2	0.2	0.8	0.9	-0.0	-0.0	-0.7	-0.5	-0.1	-0.0	-0.1	0.2	-0.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.9	0.4	0.4	0.9	0.5	0.5	0.7	0.4	0.3	0.4	0.5
Birth weight of first child	0.2	0.3	1.5	0.0	0.2	1.2	-0.1	-0.1	0.2	0.2	0.5	0.6	0.9	0.4
Heart disease (mother)	0.2	0.3	1.7	0.1	0.4	-0.2	-0.3	1.3	0.4	0.6	-0.1	0.2	-0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.3	0.3	-0.6	-0.4	-0.3	-0.3	-0.6	-0.5	-0.5	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	1.1	0.1	0.2	0.0	0.7	0.2	0.3	-0.2	0.0	-0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.0	-0.4	0.1	-0.2	0.0	0.1	-0.5	-0.5	-0.6	-1.0	-0.5	0.9
Hypertension (Self-reported)	0.2	0.4	1.7	-0.3	0.9	-0.4	-1.3	0.1	-0.1	0.7	-0.1	1.0	0.3	-0.6
Arm fat percentage (left)	0.2	1.0	3.1	-1.8	0.1	-0.6	-0.3	-1.3	-1.2	-1.0	-0.7	-0.9	-0.7	-0.9
Ever had bowel cancer screening	0.2	0.3	1.5	-0.1	-0.9	-0.5	0.0	-0.3	-0.3	-0.3	-0.1	0.4	-0.2	-1.2
Miserableness	0.2	0.3	1.2	0.1	0.8	-0.5	0.4	0.4	-0.2	-0.3	-0.5	-1.1	-0.7	0.7
Ever taken oral contraceptive pill	0.2	0.2	1.3	1.2	0.2	0.2	0.2	0.3	0.2	0.1	0.2	0.1	0.1	0.6
Medication: Blood pressure	0.2	0.4	1.0	-0.4	-1.0	0.2	0.6	1.0	0.9	0.6	0.2	0.2	-0.2	-0.0
Fractured/broken bones in last 5 years	0.2	0.3	1.1	0.8	-0.1	-0.4	-0.0	0.7	0.6	1.1	-0.1	0.5	0.3	0.3
Commuting to job workplace: Cycle	0.2	0.3	1.5	-0.0	-0.5	-0.4	0.7	-1.2	-0.4	-0.4	0.5	0.0	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-0.1	-0.4	-1.0	0.3	-0.3	-0.2	-0.4	-0.5	-0.8	-0.8	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.8	-0.5	-0.1	-0.6	0.6	0.1	0.5	0.0	0.6	0.2	0.2
Schizophrenia (2018)	0.1	0.3	1.5	0.3	1.2	0.4	-0.1	0.3	0.2	0.4	0.1	0.1	0.4	0.9
Breast Cancer	0.1	0.3	1.2	-0.8	0.2	-1.1	-0.2	-0.7	-0.6	-0.4	-0.3	-0.4	-0.5	-0.3
Ovarian Cancer	0.1	0.1	0.3	-0.1	-0.0	-0.3	0.3	-0.4	-0.2	0.3	0.4	0.3	0.6	0.3
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	-0.1	0.4	-0.3	-0.0	-0.1	0.3	-0.2	0.3	0.4	0.0
Schizophrenia (2014)	0.1	0.3	1.3	0.3	1.1	0.2	-0.1	0.7	0.2	0.6	-0.3	-0.1	0.1	0.8
Heel T-Score	0.1	1.0	2.8	0.9	-0.5	1.2	0.7	0.3	0.9	0.7	1.6	1.7	1.3	-0.1
Hypothyroidism (self reported)	0.1	0.3	1.1	-0.2	0.0	-0.1	-0.0	-0.8	-0.6	-0.8	-0.5	-1.1	-0.6	0.2
Tanning	0.1	1.0	4.0	0.3	-1.2	-0.7	1.0	-2.0	-0.5	-1.2	0.9	-0.3	-0.1	-0.9
Medication: Metformin	0.1	0.1	0.5	0.2	0.5	-0.4	-0.0	0.0	0.4	0.7	0.3	0.6	0.3	0.0
Diabetes (mother)	0.1	0.1	0.4	-0.6	-0.1	-0.3	-0.1	-0.1	0.1	0.1	0.5	0.6	0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.8	0.3	-0.1	0.6	0.1	-0.1	-0.3	-0.4	-0.1	-0.3	0.2	0.9
High blood pressure	0.1	0.4	1.3	-0.2	0.6	-0.3	-1.1	0.7	0.2	0.9	-0.1	0.8	0.1	-0.3
Multivitamins +/- minerals	0.1	0.2	0.5	0.1	0.4	-0.6	-0.6	0.2	-0.1	0.2	-0.5	0.2	-0.4	-0.7
Medication: Levothyroxine sodium	0.1	0.2	0.6	0.2	0.1	-0.3	-0.3	-0.6	-0.4	-0.3	-0.5	-0.8	-0.5	-0.3
High blood pressure (mother)	0.1	0.2	1.3	-0.3	0.4	-0.3	1.1	0.1	0.1	0.3	0.2	-0.3	0.0	0.6
Fluid intelligence score	0.1	0.2	0.8	0.9	0.4	0.3	-0.3	0.1	0.1	0.3	0.4	0.6	0.7	0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	-0.7	-0.3	0.9	0.4	-0.5	-0.1	-0.1	0.1	-0.1	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.5	0.1	-0.2	0.1	0.4	-0.7	-0.3	-0.6	-0.0	-0.6	-0.2	-0.0
Medication: Amlodipine	0.1	0.2	0.5	0.7	0.1	-0.6	-0.1	-0.4	-0.2	-0.6	-0.0	-0.2	-0.4	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.7	0.2	0.0	-0.1	0.4	0.4	0.4	0.1	0.5	0.2	0.5
High blood pressure (siblings)	0.1	0.2	0.6	0.4	0.5	0.5	0.4	0.7	0.4	0.5	-0.4	-0.2	-0.1	0.5
Migraine (self-reported)	0.1	0.1	0.6	0.8	0.4	-0.1	0.3	0.3	-0.1	-0.0	0.1	-0.3	-0.3	-0.3
Medication: Omeprazole	0.1	0.1	0.7	-0.2	-0.2	-0.5	0.8	-0.1	-0.0	-0.2	0.0	-0.3	-0.1	0.4
Loneliness, isolation	0.1	0.2	0.5	-0.6	0.3	-0.6	-0.4	-0.5	-0.0	-0.2	0.4	0.3	0.1	-0.7
Number of operations (self-reported)	0.1	0.2	0.9	-0.9	-0.3	-0.2	0.2	-0.2	-0.2	-0.6	0.4	-0.2	0.0	0.3
Supplements: Calcium	0.1	0.1	0.2	0.3	0.5	-0.3	0.3	0.3	0.1	-0.0	0.1	-0.2	-0.2	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	3.2	-1.2	-0.9	1.4	-0.2	0.1	0.4	0.2	1.1	1.4	1.8	0.9
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.1	-0.3	0.2	-0.1	0.3	-0.1	0.5	-0.5	-0.3	-0.1	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.2	-0.4	0.0	0.3	-0.4	-0.1	-0.2	0.5	0.2	0.1	-0.0

Hub : Genes

RAB4B

Models

Trait associations