Hub : Genes

SUPT5H

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1040	0.0270	1.8e-08	0.057	0.053	0.031	0.054	0.041	1.5e-07	4.2e-07	8.9e-05	3.8e-07	7.7e-06
2	GTEx	Adrenal Gland	0.2585	0.0838	2.6e-03	0.148	NA	0.019	NA	0.059	5.4e-06	NA	6.9e-02	NA	3.8e-03
3	GTEx	Cells Transformed fibroblasts	0.1590	0.0520	1.3e-03	0.041	NA	0.120	NA	0.072	4.4e-04	NA	2.8e-09	NA	4.6e-06
4	GTEx	Colon Transverse	0.0880	0.0370	6.6e-03	0.087	NA	0.018	NA	0.015	5.9e-05	NA	4.4e-02	NA	6.3e-02
5	GTEx	Liver	0.3890	0.1200	9.4e-04	0.208	NA	0.275	NA	0.197	1.8e-06	NA	2.5e-08	NA	3.6e-06
6	GTEx	Pituitary	0.4600	0.0990	1.8e-04	0.267	NA	0.375	NA	0.316	2.1e-07	NA	2.2e-10	NA	1.1e-08
7	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0250	4.3e-04	0.084	NA	0.081	NA	0.078	1.7e-07	NA	2.9e-07	NA	5.5e-07
8	GTEx	Thyroid	0.2230	0.0560	3.7e-06	0.110	NA	0.105	NA	0.112	9.2e-09	NA	2.1e-08	NA	7.0e-09
9	TCGA	Bladder Urothelial Carcinoma	0.0260	0.0160	8.5e-03	0.000	0.007	-0.003	NA	0.000	3.5e-01	7.0e-02	6.9e-01	NA	3.4e-01
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0543	0.0300	3.3e-04	0.037	0.029	0.013	NA	0.020	4.4e-05	2.7e-04	1.2e-02	NA	2.3e-03
11	TCGA	Prostate Adenocarcinoma	0.1567	0.0434	4.2e-12	0.142	0.136	0.151	NA	0.157	1.1e-14	4.5e-14	1.6e-15	NA	4.2e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.6	0.9	1.9	0.7	1.1	0.7	-0.7	1.4	1.4	0.4	0.4	1.2	0.4	1.3
Bipolar Disorder or Schizophrenia	0.4	0.9	3.0	-0.8	0.3	1.7	0.8	1.2	1.0	-0.5	1.2	0.4	-1.3	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.2	-0.8	-0.3	-0.4	-0.1	0.3	0.0	-0.6	0.2	-0.2	-0.9
Depression (Nagel 2018)	1.3	2.0	6.5	-1.0	1.0	1.9	0.6	2.5	2.4	-0.9	1.4	0.3	-0.1	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.2	9.5	1.6	-1.1	-1.4	-1.2	-3.1	-3.0	1.0	-2.5	-0.5	0.8	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	2.1	-1.4	-0.3	-0.6	0.9	0.7	0.2	-1.3	0.4	-0.8	-1.1	-0.4
Schizophrenia (2018)	0.7	1.4	3.8	-1.6	-0.5	1.4	1.6	0.5	0.2	-1.0	1.3	-0.5	-2.0	-0.8
Schizophrenia vs Biploar Disorder	3.9	5.1	11.0	-3.1	0.3	-0.4	3.3	-0.5	-1.1	-2.9	2.5	-2.9	-3.2	-0.7
Worry (Nagel 2018)	1.0	2.2	6.0	-2.5	0.2	0.2	1.4	2.1	1.5	-1.7	1.4	-0.5	-1.9	0.1
Alzheimer’s Disease (in mother)	0.7	0.9	5.1	-0.7	1.0	-0.4	0.1	2.2	0.4	-0.1	1.0	-0.3	0.6	1.0
Alzheimer’s Disease (in father)	0.5	0.6	2.0	-0.2	-1.3	-1.4	0.1	-0.2	0.4	-0.3	-0.1	-0.0	-0.6	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	-1.2	0.1	-1.6	1.1	0.8	-0.4	-0.5	0.5	-1.2	-0.3	-0.3
Crohns Disease (2017)	0.2	0.4	1.8	0.0	0.1	1.3	-0.2	-1.1	0.9	0.3	0.5	0.4	-0.6	0.2
Irritable Bowel Disease (IBD)	0.3	0.6	1.8	-0.5	1.1	1.3	-0.2	-0.7	0.7	0.3	1.1	0.3	0.2	1.2
Ulcerative Colitis (UC)	0.5	0.9	2.4	-0.8	1.6	1.1	-0.0	0.0	0.7	0.1	1.5	0.3	0.5	1.6
Major Depression (MDD)	0.5	0.6	1.5	-0.5	-0.9	-0.4	0.5	1.0	-0.7	-0.2	-0.2	-0.8	-1.1	-1.2
Reaction Time	0.4	0.8	2.2	-0.4	0.4	0.6	1.2	-1.5	-0.8	-0.9	1.2	-1.1	-0.5	0.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	8.7	2.2	-0.6	-1.2	-1.4	-2.9	-1.8	1.5	-2.0	0.3	1.3	-0.3
Breast Cancer	0.6	1.4	5.7	0.4	1.3	0.4	0.4	2.4	1.6	-0.7	1.1	0.1	-0.3	1.6
Ovarian Cancer	1.1	1.5	3.6	-1.0	1.9	0.1	1.5	0.6	-0.7	-1.5	0.8	-1.8	-0.7	1.6
Prostate Cancer	1.6	2.3	4.2	1.6	-2.1	-1.9	-1.1	-1.2	-1.5	1.2	-2.0	0.3	-0.4	-2.0
Age at First Birth	0.4	0.5	2.5	0.6	0.8	-0.6	0.1	-0.9	-0.9	0.2	-0.3	-0.2	1.6	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.8	0.6	-0.5	-0.2	0.2	0.6	-0.0	0.4	0.2	0.3	0.8
Coronary Artery Disease (CAD)	2.0	2.4	7.0	-2.6	0.9	0.3	2.6	0.7	-0.2	-2.1	2.5	0.0	0.0	0.0
Crohns Disease (2012)	0.6	1.0	2.2	0.8	0.9	1.1	-0.9	1.5	1.3	0.7	0.4	1.1	0.9	1.0
Mean Putamen Volume	1.4	1.5	3.7	-0.7	1.6	1.2	0.2	1.6	1.7	-0.1	1.9	0.4	-0.5	1.6
Fasting Glucose	0.2	0.2	1.2	0.5	0.4	-0.4	-0.1	0.2	1.1	0.6	0.2	0.1	-0.4	0.3
HbA1C	0.3	0.3	1.0	0.8	0.4	-0.5	0.0	-0.3	-0.9	0.1	-0.1	-0.6	1.0	0.4
HDL Cholesterol	0.2	0.4	1.3	-0.8	0.3	0.7	0.6	1.1	0.4	-0.6	0.6	-0.4	-0.1	0.1
LDL Cholesterol	0.8	1.3	3.9	-2.0	-0.6	1.5	0.8	1.5	0.9	-1.0	0.4	-0.3	-1.3	-1.2
Lupus	0.6	0.9	3.6	0.8	-1.0	-1.9	-0.1	0.5	-1.2	0.3	-0.8	-0.5	0.6	-1.3
Neuroticism (2016)	0.1	0.1	0.5	-0.1	0.2	0.5	-0.3	-0.7	-0.0	-0.1	0.0	0.2	0.0	0.1
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.7	0.7	0.1	-0.3	0.6	-0.3	0.2	0.0	0.2	0.8	0.9
Rheumatoid Arthritis	3.5	4.8	10.0	-1.9	2.8	2.7	1.8	2.0	2.3	-1.8	3.2	-0.5	-1.3	2.4
Schizophrenia (2014)	0.7	1.6	4.2	-2.0	0.1	0.8	1.7	-0.0	-0.4	-1.4	1.4	-1.0	-2.0	-0.5
Triglycerides	1.1	1.8	4.2	0.0	1.8	1.2	1.3	2.0	-0.3	-1.4	1.8	-1.1	-0.8	1.5
Type 2 Diabetes (T2D) (2012)	0.6	0.6	5.5	0.4	0.4	-2.3	0.7	0.7	-0.3	-0.1	0.3	0.0	0.0	0.0
Ulcerative Colitis	0.8	1.1	2.3	-0.5	1.4	0.6	-0.5	1.5	0.4	0.2	1.5	0.8	1.4	1.5
Blood Eosinophil Count	4.5	34.5	320.4	-0.6	2.5	0.8	-1.5	17.9	3.7	1.5	1.5	2.4	3.8	3.4
Blood Platelet Count	0.1	0.8	2.8	0.1	1.7	1.3	0.7	-0.5	0.3	-0.3	0.8	-0.2	-0.5	1.6
Blood Red Count	0.2	2.0	12.7	1.2	-0.9	0.2	-1.2	3.6	1.2	0.8	0.0	1.6	0.5	-0.4
Blood White Count	2.2	16.6	44.8	4.8	-1.2	0.0	-6.0	2.0	1.5	5.8	-3.2	5.2	6.7	0.1
Heel T-Score	0.2	1.8	3.2	-1.0	1.8	1.2	1.6	0.3	1.2	-1.8	1.7	-1.0	-0.9	1.6
BMI	0.1	0.6	2.3	-0.2	-1.3	-0.6	-0.4	0.1	1.5	0.5	-0.0	0.9	-0.3	-1.1
Height	0.2	4.1	9.7	0.4	-3.0	-3.1	-1.4	-2.1	-1.5	1.9	-1.9	0.6	0.9	-3.1
Waist Hip Ratio (WHR)	0.2	0.8	3.4	-0.0	-0.6	1.8	-0.0	0.4	1.8	-0.1	1.0	0.3	-0.5	-0.5
Systolic Blood Pressure	0.3	1.7	5.8	0.8	-0.5	2.0	-1.2	2.4	1.5	0.5	0.8	1.8	0.5	-0.2
Smoking Status	0.3	0.6	5.1	-0.4	-0.2	-0.2	0.2	2.3	0.8	0.1	0.5	0.2	-0.9	-0.1
Allergy or Eczema	3.2	8.3	17.6	4.0	-2.3	-1.0	-4.1	-0.0	0.9	4.2	-3.1	3.5	2.8	-1.8
Cardiovascular Disease	0.5	1.6	7.3	0.6	-2.7	-1.1	-0.5	0.3	-0.3	-0.1	-1.4	0.1	-0.3	-2.4
Hypothyroidism (self reported)	0.1	0.2	0.8	0.0	0.2	0.6	-0.1	-0.0	0.6	0.3	0.1	0.2	0.9	0.5
Respiratory disease	1.6	3.6	11.8	3.4	-1.8	0.5	-2.3	1.4	1.1	2.1	-1.8	2.1	1.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.1	-1.1	0.9	0.9	1.4	0.1	0.5	-1.8	1.4	-1.1	-0.7	0.7
Lung FEV1/FVC ratio	0.2	0.9	3.1	-1.1	0.1	1.2	-0.3	1.1	1.8	-0.1	1.4	0.4	0.3	0.0
Lung FVC	0.3	1.4	3.8	0.8	1.8	1.6	-0.6	0.6	1.2	0.4	1.0	1.0	1.0	1.9
Neuroticism	0.2	0.5	1.5	-1.2	-1.1	-0.6	-0.1	0.2	0.2	-0.4	-0.3	-0.1	-0.7	-1.1
Chronotype (morning person)	0.7	1.7	6.3	-0.6	2.5	0.7	0.8	-1.6	-0.2	-0.3	0.3	-0.9	1.4	2.4
Hair Pigment	0.1	1.4	3.5	-0.4	1.1	1.6	1.9	-1.1	0.3	-0.9	1.0	-1.2	-1.8	0.8
Tanning	0.1	1.1	2.5	1.4	0.5	0.5	-1.1	-0.5	1.4	1.6	-0.1	1.4	1.1	1.1
Hand grip strength (left)	0.4	1.0	2.8	0.4	-1.3	-1.2	0.4	-1.1	-1.7	-0.1	-0.7	-0.8	-0.6	-1.4
Number of treatments/medications taken	1.0	1.8	3.5	1.8	-1.4	-0.7	-1.4	1.9	1.1	1.6	-1.2	1.2	1.2	-0.7
Average weekly spirits intake	1.7	2.2	4.3	-2.0	1.6	-0.0	1.6	0.8	0.8	-2.1	1.6	-1.4	-1.5	1.5
Sensitivity / hurt feelings	0.5	0.9	3.2	-0.4	-0.8	-0.7	-0.0	-1.8	-1.8	0.0	-0.7	-0.6	0.3	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	3.1	-0.1	-0.1	1.1	0.1	1.8	0.9	-0.2	0.2	-0.0	-0.1	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.1	-0.1	-0.7	1.3	-1.2	-0.7	-1.3	0.0	-1.1	-0.7	-0.0
Relative age of first facial hair	1.3	2.7	7.2	1.7	-2.1	-1.0	-1.7	-2.7	0.3	1.6	-1.9	1.6	0.1	-1.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.1	-0.2	-0.7	0.8	-0.7	1.4	0.8	0.1	0.0	0.7	0.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.1	1.2	-0.5	0.9	0.3	-0.6	-0.1	0.5	-0.9	0.4	1.0
Ever had hysterectomy (womb removed)	1.9	2.1	5.1	-2.0	1.8	0.5	2.3	0.8	0.2	-1.3	1.9	-1.2	-1.1	1.5
Systolic blood pressure, automated reading	0.4	1.1	2.6	-0.5	0.7	1.6	0.6	1.3	1.5	-0.8	1.6	-0.0	-0.8	0.7
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	6.8	-1.5	2.6	2.0	1.5	1.1	0.9	-1.5	2.3	-0.6	-0.3	2.5
Angina	1.5	2.0	5.4	-1.3	0.6	0.2	2.1	-0.4	-1.0	-2.3	0.5	-2.1	-1.9	0.1
Medication for hormone replacement therapy	1.8	2.0	6.4	-0.0	2.5	1.4	1.4	1.1	0.5	-1.1	1.4	-1.1	-0.7	2.4
Vitamin and mineral supplements	0.5	0.7	2.5	-0.5	0.2	0.9	0.7	-0.8	-1.6	-0.8	0.5	-1.2	-0.3	-0.1
Supplements: Zinc	0.2	0.2	0.7	0.3	-0.4	-0.3	-0.6	0.4	0.6	0.4	-0.8	0.6	-0.4	-0.3
Medication: Co-codamol	0.7	0.8	3.6	-0.3	-0.2	-0.7	0.2	1.9	1.5	-0.4	1.0	0.4	-1.1	-0.1
Medication: Metformin	0.7	1.0	2.3	-1.4	1.2	0.8	0.8	0.4	1.1	-0.8	1.5	-0.4	-0.6	1.0
Diabetes (father)	0.8	1.0	2.4	-0.9	-0.4	-1.4	1.3	0.7	-0.2	-1.3	0.3	-1.2	-1.5	-0.6
Diabetes (mother)	1.1	1.4	3.2	-1.2	-0.4	-0.9	1.4	0.5	-0.9	-1.7	0.6	-1.7	-1.8	-0.9
Severe depression (siblings)	0.9	1.0	2.2	-0.9	-0.9	0.2	0.8	-1.0	-1.2	-1.4	-0.2	-1.1	-1.5	-1.0
Pack years adult smoking proportion	0.3	0.4	0.9	-0.5	1.0	0.5	0.5	0.1	-1.0	-0.4	0.9	-0.5	0.5	0.9
Impedance of leg (right)	0.1	0.3	0.8	0.7	0.5	0.4	0.0	-0.2	-0.9	0.2	-0.8	-0.2	-0.6	0.3
Leg fat-free mass (left)	0.2	1.3	5.2	-0.6	-2.3	-1.0	-0.4	-0.8	0.7	0.4	-0.2	0.5	-0.4	-2.3
Trunk fat percentage	0.2	0.6	3.2	-0.4	-0.8	0.4	-0.4	-0.6	1.8	0.7	-0.2	1.0	-0.4	-0.7
Hand grip strength (right)	0.3	0.9	3.7	0.5	-1.9	-0.6	0.0	-0.6	-0.7	0.5	-0.8	-0.2	-0.2	-1.9
Townsend deprivation index at recruitment	1.1	1.6	9.1	-0.4	1.1	3.0	-0.1	-0.7	1.6	0.4	0.8	0.7	0.4	1.3
Current tobacco smoking	0.5	0.8	5.3	-0.3	0.8	1.0	0.5	2.3	0.5	-0.1	0.9	-0.1	-0.0	0.6
Average weekly fortified wine intake	0.8	0.9	1.9	-0.8	1.1	1.4	0.8	0.6	0.7	-0.6	1.3	0.0	-1.1	1.2
Maternal smoking around birth	0.4	0.6	2.6	0.9	1.4	0.8	-0.1	0.0	0.3	0.4	0.1	0.5	0.2	1.6
Fed-up feelings	0.2	0.3	1.1	-0.2	1.1	-0.1	0.5	-0.6	-0.6	-0.6	-0.1	-0.8	-0.0	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.7	-1.9	0.8	1.4	1.3	1.3	1.4	-1.5	1.0	-1.0	-1.3	0.5
Relative age voice broke	0.6	0.9	5.0	1.0	-0.6	-1.2	-0.2	-2.2	-1.0	0.5	-1.1	0.2	-0.2	-0.4
Taking other prescription medications	1.7	2.7	8.3	2.4	-0.7	-0.4	-2.2	-0.3	0.5	2.4	-1.2	1.5	2.9	-0.2
Age when periods started (menarche)	0.3	0.7	1.5	0.5	-0.8	0.2	-0.5	-1.2	-1.1	1.1	-1.0	0.5	-0.2	-1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.6	0.4	0.0	-1.6	-0.3	1.0	-0.8	0.8	-0.5	0.2	1.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.6	0.4	1.2	0.5	0.9	0.0	0.2	-0.8	1.1	-0.7	-0.6	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.1	1.0	0.7	-0.2	0.5	0.1	0.7	0.5	0.3	1.2	1.0
Qualifications: CSEs or equivalent	1.0	1.4	3.8	-1.0	1.2	1.5	0.7	0.9	1.5	-0.6	1.9	0.2	-1.0	1.2
Serious illness, injury or assault to yourself	1.8	2.2	6.1	0.5	0.4	2.5	-1.3	1.3	2.2	1.4	0.6	1.9	1.8	0.7
High blood pressure	0.1	0.2	0.6	-0.5	-0.4	0.7	-0.1	0.8	0.5	-0.4	0.0	-0.2	0.5	-0.2
Hayfever, allergic rhinitis or eczema	3.1	6.8	13.6	3.4	-2.5	-1.1	-3.7	-0.2	0.4	3.6	-3.0	3.1	2.5	-1.9
Multivitamins +/- minerals	0.7	0.9	2.0	0.9	-0.0	-0.9	-0.8	1.4	1.3	0.9	-0.3	1.2	1.2	0.3
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.5	0.4	-0.4	-0.3	-0.4	-0.0	0.7	-0.3	0.5	0.5	0.3
Supplements: Glucosamine	1.3	1.7	3.8	0.9	-1.0	-1.9	-1.2	-1.8	1.3	1.5	-1.3	1.2	1.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.8	0.6	-0.8	-0.6	-0.8	-0.8	0.0	1.1	-1.7	0.8	0.4	-0.7
Medication: Atenolol	1.2	1.5	3.1	-1.4	0.6	0.8	1.6	1.4	0.5	-1.8	1.7	-1.3	-1.0	0.3
Medication: Levothyroxine sodium	0.3	0.5	1.3	-1.0	0.6	-0.0	0.4	-1.1	0.7	-0.4	0.3	-0.4	1.0	0.6
Sitting height	0.3	2.2	6.5	-0.2	-2.4	-2.0	-1.0	-0.5	-1.4	1.3	-1.5	0.3	0.7	-2.6
Chronic bronchitis/emphysema (father)	0.9	1.0	4.1	-0.3	0.0	-0.6	1.2	-2.0	-1.3	-0.9	-0.1	-1.5	-0.4	-0.2
High blood pressure (mother)	1.0	1.4	6.2	0.4	-1.5	-0.4	-1.1	-1.3	-2.5	0.2	-1.1	-0.1	0.3	-1.7
Body mass index (BMI)	0.1	0.6	4.3	-0.5	-0.5	0.2	0.3	-0.2	2.1	0.0	0.7	0.6	-0.7	-0.5
Impedance of leg (left)	0.1	0.4	1.1	0.4	1.0	1.0	0.1	0.0	-0.8	0.2	-0.6	-0.3	-0.1	0.9
Leg predicted mass (left)	0.2	1.1	4.7	-0.7	-2.1	-1.0	-0.3	-0.8	0.8	0.3	-0.1	0.5	-0.5	-2.2
Trunk fat mass	0.2	1.0	2.7	-0.3	-1.6	-0.3	-0.5	-0.8	1.6	0.9	-0.5	1.0	-0.4	-1.6
Waist circumference	0.3	1.3	5.5	-1.0	-1.6	0.9	-0.1	-0.3	2.4	0.2	0.3	0.8	-1.1	-1.5
Number of incorrect matches in round	0.3	0.5	1.7	0.1	0.1	-0.6	1.0	0.8	0.1	-0.8	0.8	-0.6	-1.3	-0.2
Past tobacco smoking	0.3	0.6	1.3	0.6	1.1	0.5	0.4	0.2	-0.5	-0.9	0.9	-0.2	1.0	1.0
Alcohol usually taken with meals	0.7	1.1	4.5	-0.5	1.9	-0.1	0.4	-1.1	-0.3	-0.6	0.6	-0.3	1.4	2.1
Nervous feelings	0.9	1.6	4.6	-2.1	0.1	0.5	1.6	0.6	-0.2	-2.1	1.3	-1.2	-1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	6.6	-2.6	0.5	1.7	2.0	1.7	0.8	-1.9	1.8	-1.3	-1.8	-0.0
Hearing difficulty/problems with background noise	0.3	0.5	2.1	-0.2	-0.4	-1.0	0.0	-0.5	-1.4	0.3	-1.0	-0.5	0.6	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	-0.8	0.2	0.3	-0.0	-0.3	0.7	0.1	-0.4	0.3	-0.6	0.3
Had menopause	0.5	0.6	1.4	-0.5	1.2	0.4	1.0	-0.1	0.5	-0.7	0.9	-0.8	-0.0	1.1
Had other major operations	0.7	0.9	2.6	-0.5	1.4	0.9	0.7	0.4	1.6	-0.5	1.3	0.2	-0.2	1.2
Forced vital capacity (FVC)	0.1	0.5	1.6	-0.2	-0.6	-1.2	0.5	-0.4	-1.1	-0.5	0.2	-0.9	-0.7	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	1.0	0.7	0.5	0.5	0.4	0.1	-0.6	0.8	-0.2	-0.8	0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	-0.7	-0.9	-1.1	0.3	1.3	0.0	-0.4	-0.0	-0.6	-0.9	-1.1
Qualifications: None of the above	0.5	1.1	3.1	-1.0	1.3	0.2	0.9	1.8	0.8	-1.0	1.4	-0.3	-0.9	1.2
Financial difficulties in last 2 years	1.0	1.3	4.5	0.8	0.6	1.2	-0.9	1.2	2.1	0.9	-0.2	1.2	1.4	1.0
Mouth/teeth dental problems	0.6	0.9	2.9	1.4	0.6	0.5	-0.5	-1.7	1.3	0.6	0.6	1.0	0.3	0.7
Heart attack	2.1	2.6	7.2	-2.0	1.2	0.6	2.1	1.5	-1.5	-2.2	1.5	-2.7	-0.7	0.6
Allergy	2.5	5.7	10.6	-3.1	2.8	1.3	3.3	-0.4	-0.4	-3.1	2.8	-2.6	-1.8	2.4
Pain all over the body in last month	1.4	1.5	3.4	-1.0	-1.3	-1.2	1.2	0.0	-1.4	-1.2	-0.1	-1.2	-1.8	-1.7
Diabetes (self-reported)	0.3	0.5	1.5	-1.2	-0.2	0.3	0.9	-0.6	0.2	-0.8	0.6	-0.7	-0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	7.1	1.7	-1.9	-2.3	-2.7	-2.5	-1.0	2.3	-2.7	1.5	2.0	-1.4
Medication: Ramipril	1.1	1.4	8.1	-1.4	0.5	1.4	0.7	2.8	0.9	-0.6	1.0	-0.3	-0.5	0.5
Medication: Simvastatin	0.3	0.5	1.1	-0.9	-0.2	0.9	0.7	0.7	0.7	-1.1	0.6	-0.6	-0.7	-0.4
Fluid intelligence score	1.7	3.4	8.2	1.9	-1.4	-1.8	-1.6	-2.8	-2.9	1.1	-2.4	-0.2	1.4	-1.2
Illnesses of siblings	1.3	1.8	4.1	-0.5	0.7	-1.1	2.0	0.6	-1.7	-1.7	0.4	-1.9	-1.8	0.3
Neuroticism score	0.1	0.2	0.8	-0.9	-0.4	-0.4	0.2	0.2	0.1	-0.4	-0.1	-0.3	-0.4	-0.6
Weight	0.2	1.2	3.8	-0.5	-1.9	-0.8	-0.4	-1.1	1.3	0.8	-0.3	0.7	-0.3	-2.0
Impedance of arm (right)	0.4	1.9	4.8	1.5	-0.5	0.8	-2.2	0.1	0.2	1.9	-1.8	1.9	1.4	-0.2
Arm fat percentage (right)	0.3	1.2	4.2	0.1	-1.4	0.1	-0.9	-0.7	2.0	1.2	-0.6	1.5	-0.2	-1.2
Trunk fat-free mass	0.3	1.6	6.4	-0.6	-2.5	-1.6	-0.4	-1.2	0.1	0.7	-0.4	0.3	-0.3	-2.5
Hip circumference	0.1	0.5	1.8	-0.7	-1.0	0.1	-0.5	-0.6	1.3	0.7	0.1	0.9	-0.1	-0.9
Time employed in main current job	0.4	0.5	1.0	-0.1	0.7	0.2	0.9	0.4	-0.7	-1.0	0.2	-1.0	-1.0	0.9
Alcohol intake versus 10 years previously	1.0	1.4	2.2	-1.4	1.4	1.1	1.5	-1.0	1.4	-0.8	1.5	-0.4	-1.0	1.2
Father’s age at death	0.7	1.0	1.6	1.2	-1.1	-1.1	-1.0	-0.9	-1.0	0.4	-1.3	-0.0	1.2	-0.8
Worrier / anxious feelings	1.5	2.8	6.9	-2.3	-0.3	-1.4	2.3	-0.0	-1.1	-2.2	0.6	-2.2	-2.6	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.0	0.7	0.3	0.8	-0.2	1.4	0.6	-0.1	0.5	0.2	0.7	0.2
Falls in the last year	0.4	0.6	1.9	0.3	0.7	1.4	0.0	0.4	1.1	0.2	0.8	0.4	1.0	0.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.5	0.7	-0.7	0.5	0.1	-0.0	-0.3	0.7	-0.7	-0.1	0.7
Number of live births	0.4	0.5	3.9	-0.3	-0.2	0.5	0.1	2.0	-0.0	-0.3	0.1	0.2	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.5	-0.5	-0.5	0.4	-0.0	-0.3	-0.5	0.6	-0.5	-0.8	-0.8
Pulse rate	1.3	2.1	9.8	0.1	0.6	3.1	-0.8	1.2	2.7	0.2	1.2	1.3	-0.1	1.1
Happiness	1.7	2.0	5.0	-0.8	1.5	2.2	1.0	1.9	1.7	-0.9	1.7	-0.1	-0.6	1.6
Noisy workplace	1.8	2.2	4.6	-0.7	1.9	2.1	0.7	1.7	1.7	-1.0	1.9	0.9	0.4	1.9
Qualifications: A levels/AS levels or equivalent	1.9	4.1	14.2	0.8	-2.4	-2.5	-0.3	-2.3	-3.8	0.2	-2.4	-1.1	0.2	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	6.9	0.7	-2.4	-0.9	-2.2	-1.6	0.0	1.7	-2.6	1.7	1.3	-1.9
Mouth/teeth dental problems: Dentures	0.6	0.9	3.0	-1.0	-1.0	-0.4	-0.0	-0.8	-1.7	-0.3	-1.3	-1.0	0.3	-1.2
Asthma	1.1	2.2	5.7	2.4	-1.7	-0.3	-2.0	1.3	0.7	1.5	-1.6	1.5	0.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	5.5	2.2	-2.0	-0.1	-2.0	-0.3	1.6	2.2	-1.1	2.4	1.0	-1.5
Medication: Cholesterol lowering	0.8	1.2	3.4	-1.9	-0.2	0.4	1.1	1.3	-0.2	-1.5	0.5	-1.4	-1.5	-0.4
Depression (self-reported)	0.1	0.1	0.2	0.0	-0.2	-0.0	-0.4	0.1	0.5	0.5	-0.1	0.5	0.4	-0.2
Medication: Lansoprazole	0.8	1.0	2.5	-0.4	1.6	1.3	0.9	0.6	0.5	-0.6	1.3	-0.6	-0.2	1.5
Prospective memory result	0.7	0.8	4.1	0.0	0.4	1.0	-0.3	2.0	1.5	-0.1	0.4	1.1	0.1	0.4
Lung cancer (father)	0.2	0.3	1.1	-0.0	0.5	-0.5	0.2	-1.1	0.3	-0.1	0.3	0.1	-0.9	0.6
Illnesses of mother	0.6	0.8	1.7	-0.8	0.8	0.5	1.2	-0.2	1.0	-0.5	1.1	-0.5	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.5	0.1	-0.1	-0.1	0.3	-0.4	-0.7	-0.3	0.2	-0.5	-0.2	-0.4
Pulse wave Arterial Stiffness index	1.9	2.2	5.9	-1.2	1.9	2.2	0.6	0.4	2.4	-0.8	1.7	0.3	-0.6	1.9
Impedance of arm (left)	0.1	0.6	2.0	0.5	-0.2	0.3	-1.2	-0.1	-0.2	1.0	-1.4	0.9	0.8	-0.1
Arm fat mass (right)	0.3	1.1	3.0	-0.1	-1.7	-0.5	-0.7	-0.8	1.7	1.1	-0.5	1.2	-0.2	-1.6
Trunk predicted mass	0.3	1.6	6.4	-0.6	-2.5	-1.5	-0.4	-1.1	0.2	0.6	-0.3	0.3	-0.4	-2.5
Standing height	0.4	4.1	12.7	-0.2	-3.4	-2.4	-1.4	-1.8	-1.3	1.7	-2.1	0.4	0.8	-3.6
Length of working week for main job	0.7	0.8	5.0	0.6	-1.0	0.2	-0.5	2.2	0.6	0.6	-0.6	0.4	-0.1	-0.9
Exposure to tobacco smoke at home	1.2	1.3	5.7	-0.7	0.8	0.8	1.0	2.4	1.1	-0.9	1.5	-0.5	-1.3	0.4
Breastfed as a baby	1.5	1.9	4.6	1.6	-1.1	1.7	-1.8	-0.6	0.7	1.9	-0.7	2.1	1.1	-0.5
Tense / ‘highly strung’	1.7	2.9	5.3	-1.7	2.3	1.2	1.6	2.0	1.1	-1.6	2.3	-1.1	-0.9	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	5.0	0.5	-2.2	-1.1	-0.8	-0.8	0.1	1.2	-1.5	0.5	0.5	-2.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.1	0.2	0.0	0.7	-0.6	-0.8	-0.2	0.5	-0.5	-0.3	0.1
Birth weight of first child	0.5	0.9	5.3	0.0	-0.2	-2.3	0.2	-1.6	-0.6	-0.4	-0.2	-0.8	0.3	-0.3
Peak expiratory flow (PEF)	0.3	0.6	1.6	0.6	-1.2	0.2	-1.0	-0.8	0.5	1.0	-0.2	0.8	-0.1	-1.2
Pulse wave reflection index	0.3	0.4	1.3	-0.5	1.2	0.8	0.4	-0.2	0.5	-0.5	0.5	0.1	-0.3	1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.3	-1.4	0.6	-0.5	2.1	1.1	-0.1	-1.6	1.6	-1.6	-2.0	0.0
Loud music exposure frequency	0.8	0.9	2.3	-1.0	-0.4	-0.6	1.1	-0.3	-1.2	-1.0	-0.3	-1.0	-1.5	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	0.8	-1.4	-1.2	-0.9	-1.0	-0.4	0.7	-1.4	0.1	0.7	-1.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-1.1	-0.2	-0.2	0.7	1.2	-0.6	-0.8	0.1	-0.8	-0.9	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.8	-0.2	-0.1	0.1	-0.4	0.9	0.3	0.3	-0.2	0.5	0.2	-0.1
Medication: Paracetamol	0.6	1.0	3.3	-0.8	-1.0	-0.9	-0.6	1.8	1.5	0.7	-0.6	0.8	-0.1	-0.8
Headache pain in last month	0.8	1.4	4.1	0.9	-0.9	0.9	-1.7	-0.6	0.2	1.4	-1.1	1.4	2.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.3	1.8	0.2	-0.5	-0.9	-1.8	-0.1	1.5	-0.6	1.3	1.1	0.3
Glaucoma (self-reported)	0.3	0.3	1.3	-0.1	0.0	-0.3	-0.5	-0.8	-0.9	0.6	-0.6	-0.3	1.1	-0.1
Gout (self-reported)	0.9	1.3	2.9	-1.0	-0.3	-0.9	1.4	-1.7	-0.8	-1.0	-0.1	-1.7	-1.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.4	0.2	0.1	0.4	-1.1	-1.1	1.3	1.2	-0.4	1.1	1.9	0.7
Medication: Amlodipine	0.7	1.0	2.7	0.3	-1.5	-0.7	-0.8	-0.4	-1.6	0.6	-1.4	-0.0	1.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.6	1.4	-1.1	-0.3	-0.5	1.6	0.0	0.6	-0.9	0.5	0.0	-0.9
Birth weight	0.6	1.2	6.3	-0.9	-0.6	-1.1	1.2	-2.5	0.0	-0.6	0.4	-1.0	-0.9	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.0	0.3	-1.0	-0.6	-0.3	-1.7	-0.5	0.4	-1.2	-0.0	0.3	-0.9
High blood pressure (siblings)	1.7	2.4	6.2	0.9	-1.3	1.0	-2.5	0.4	1.6	1.8	-0.8	2.2	2.1	-0.9
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	0.0	-0.0	-0.5	0.6	-0.2	-1.0	-0.6	0.2	-0.8	-0.5	-0.4
Body fat percentage	0.2	0.6	2.7	-0.0	-1.0	0.2	-0.4	-0.7	1.6	0.8	-0.3	1.0	-0.5	-0.9
Leg fat percentage (right)	0.3	1.0	2.1	0.5	-1.5	-0.4	-0.4	-0.9	1.5	0.8	-0.6	0.9	-1.0	-1.4
Arm fat-free mass (right)	0.2	0.9	2.4	-1.4	-1.4	-0.9	0.7	-0.8	0.2	-0.2	0.6	-0.4	-0.9	-1.6
Exposure to tobacco smoke outside home	2.1	2.8	9.8	1.1	1.1	3.1	-1.1	1.3	1.9	1.4	1.1	2.2	1.5	1.5
Comparative body size at age 10	0.5	1.4	3.6	-0.9	-0.4	-1.7	1.9	0.1	0.6	-1.3	0.2	-1.4	-1.8	-0.4
Number of full brothers	0.4	0.5	2.1	0.5	0.4	1.3	-0.3	0.1	1.4	0.3	0.6	1.0	-0.4	0.4
Worry too long after embarrassment	1.9	3.2	7.9	-2.4	0.7	-1.1	2.3	1.2	-0.4	-2.8	1.7	-1.9	-2.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.1	-0.8	0.2	-0.1	-0.5	0.3	0.2	0.1	0.2	-0.4	-0.9
Wheeze or whistling in the chest in last year	0.4	0.7	2.3	1.3	-0.1	-0.3	-0.9	1.3	-0.1	0.8	-0.3	0.7	1.5	0.2
Number of children fathered	0.4	0.4	1.7	-0.2	0.7	-0.8	0.5	0.2	-1.3	-0.7	-0.1	-0.9	-0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	10.2	-1.7	-0.6	-1.7	2.4	-1.4	-1.8	-2.3	0.5	-2.5	-3.2	-1.0
Age at first live birth	0.3	0.5	1.4	-0.2	-0.6	-0.6	-0.8	-0.7	-0.8	0.2	-1.1	0.3	1.2	-0.4
Pulse wave peak to peak time	2.2	2.6	6.2	1.3	-2.2	-2.4	-0.8	-0.5	-2.5	1.0	-1.9	-0.2	0.8	-2.1
Health satisfaction	0.9	1.1	2.7	-1.0	1.5	0.8	0.9	1.4	0.6	-0.7	1.6	-0.4	-0.2	1.4
Shortness of breath walking on level ground	0.7	0.8	1.8	-0.9	0.9	0.2	1.4	0.9	0.4	-0.9	1.3	-1.0	-0.7	0.6
Qualifications: College or University degree	0.5	1.7	7.4	-0.1	-0.6	-1.3	0.1	-2.0	-2.7	-0.0	-1.6	-1.4	-0.0	-0.7
Eye problems/disorders: None of the above	1.0	1.1	2.4	1.5	-1.2	-1.5	-0.4	-1.1	-0.9	0.5	-1.4	0.0	-0.5	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.7	-1.3	0.1	-0.1	1.2	-0.1	-1.9	-1.0	0.1	-1.5	-0.7	-0.2
Emphysema/chronic bronchitis	0.3	0.3	2.0	-0.3	0.2	1.4	0.1	-0.9	0.2	0.2	0.1	0.4	-0.4	0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	3.6	-0.6	-0.1	-0.4	0.5	-1.9	-1.9	-0.4	-0.3	-0.9	-0.6	-0.6
Neck or shoulder pain in last month	0.2	0.3	1.3	-0.0	0.9	0.2	-0.1	0.6	-0.2	-0.1	0.6	-0.0	1.1	0.9
Medication: Blood pressure	0.4	0.8	3.4	-1.8	-0.2	0.4	0.6	1.4	0.0	-1.0	0.4	-1.1	-0.3	-0.3
Angina (self-reported)	1.8	2.3	6.5	-1.6	0.8	0.1	2.4	-0.3	-0.9	-2.5	0.7	-2.2	-2.1	0.2
Migraine (self-reported)	2.2	2.8	11.0	-1.6	1.8	1.2	0.8	3.3	1.3	-1.6	1.9	-0.5	-0.0	1.9
Medication: Ibuprofen	4.7	5.6	9.8	3.1	-3.0	-0.9	-3.0	-0.7	1.1	3.1	-2.4	2.9	1.4	-2.4
Medication: Allopurinol	0.7	0.9	2.9	-1.7	0.2	0.0	1.0	-1.3	-0.1	-1.1	0.5	-1.1	-1.3	-0.0
Medication: Omeprazole	0.9	1.1	4.1	0.8	1.1	0.5	-0.5	2.0	1.4	0.2	1.0	0.7	0.9	1.1
Medication: Seretide 50 evohaler	0.5	0.5	1.7	0.5	-1.3	-1.0	-0.2	0.1	-0.9	0.4	-0.7	0.0	-0.0	-1.1
Mean time to correctly identify matches	0.3	0.6	3.3	-0.1	0.2	0.2	1.0	-1.8	-0.9	-0.4	0.7	-0.8	-0.3	0.0
Heart disease (mother)	0.8	1.0	3.5	-0.6	0.4	0.2	1.3	1.9	0.5	-1.2	0.9	-0.5	-1.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	4.4	-0.6	-0.4	-0.2	0.8	-2.1	-0.8	-0.2	0.1	-0.9	-0.8	-0.6
Whole body fat mass	0.2	1.0	2.9	-0.3	-1.7	-0.5	-0.4	-0.9	1.5	0.7	-0.4	0.9	-0.6	-1.6
Leg fat mass (right)	0.2	0.9	2.5	-0.0	-1.6	-0.4	-0.2	-1.0	1.4	0.5	-0.2	0.7	-0.9	-1.6
Arm predicted mass (right)	0.2	1.1	3.2	-1.3	-1.6	-1.3	0.6	-0.7	0.2	-0.2	0.5	-0.4	-1.0	-1.8
Pulse rate, automated reading	0.7	2.3	9.6	-1.0	-0.3	3.1	-0.3	2.7	2.2	-0.3	1.3	0.7	-0.4	-0.0
Alcohol intake frequency.	2.8	6.5	16.7	1.5	1.7	3.4	-1.9	1.6	4.1	1.9	1.7	3.5	2.9	2.2
Comparative height size at age 10	0.4	2.0	5.4	-1.6	-1.6	-2.3	0.2	-2.0	-0.6	0.2	-1.3	-1.1	0.5	-2.0
Number of full sisters	1.6	1.9	4.7	1.2	-0.9	1.9	-1.4	1.8	1.6	1.2	0.0	2.2	0.9	-0.5
Suffer from ‘nerves’	0.3	0.4	1.5	-0.4	-1.2	-0.6	0.2	0.0	0.5	-0.5	0.1	-0.3	-0.9	-1.2
Overall health rating	0.7	1.4	7.6	-0.3	0.2	1.9	0.1	2.8	1.5	-0.4	1.0	0.4	0.6	0.4
Chest pain or discomfort	0.1	0.2	1.7	1.3	0.1	-0.3	0.1	0.2	-0.5	-0.2	0.0	-0.0	0.1	0.1
Had major operations	1.2	1.4	5.1	-0.0	-1.0	-1.1	0.1	-2.1	-2.3	0.5	-1.1	-0.7	-0.1	-1.1
Age at last live birth	0.4	0.6	3.9	-1.1	-0.3	2.0	-0.1	1.1	0.1	-0.4	0.0	0.2	-0.5	-0.2
Family relationship satisfaction	1.2	1.4	4.9	0.1	1.1	1.9	0.2	2.2	1.5	-0.1	1.1	0.7	0.7	1.2
Leg pain on walking	0.2	0.2	1.1	-0.0	0.1	-0.7	0.3	1.1	-0.2	-0.1	0.1	-0.5	0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.2	0.3	-0.1	0.1	0.8	1.5	-0.7	-0.5	0.1	-0.8	-0.4	-0.2
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.9	-1.3	2.4	0.5	1.9	1.5	-1.0	-2.4	2.4	-1.9	-0.7	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	-0.3	0.6	-0.9	1.1	-0.5	-1.2	-1.0	0.8	-1.2	-0.7	0.3
Medication: Aspirin	2.0	2.7	4.8	-1.6	1.8	1.1	2.0	2.1	0.3	-2.2	1.5	-1.7	-1.1	1.7
Supplements: Vitamin C	0.9	1.1	4.1	0.1	0.4	1.5	-0.2	1.3	2.0	0.7	0.8	1.4	-0.7	0.6
Knee pain experienced in last month	0.2	0.2	0.9	0.8	-0.4	-0.9	-0.6	0.0	0.2	0.5	-0.2	0.4	0.2	-0.4
Hypertension (Self-reported)	0.1	0.2	0.5	-0.3	-0.6	0.7	-0.3	0.6	0.5	-0.1	-0.2	-0.0	0.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.3	1.8	-0.3	0.3	-1.6	0.6	0.8	1.2	-0.5	1.5	1.2	0.1
Illnesses of father: Heart disease	3.2	4.5	11.8	-3.1	1.8	-0.3	2.9	-0.6	-1.1	-3.0	1.9	-3.4	-1.1	1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.8	-0.5	-0.5	-0.2	-0.1	0.4	0.4	-0.5	0.3	0.5	-0.3
Smoking status: Previous	0.5	0.8	2.2	-0.7	-1.5	-1.0	-0.0	0.2	0.4	0.3	-0.7	-0.1	-1.4	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.9	-1.1	0.3	0.8	1.6	-0.1	-0.5	-1.4	1.1	-1.7	-0.8	-0.0
Whole body fat-free mass	0.3	1.5	6.2	-0.7	-2.4	-1.4	-0.3	-1.0	0.3	0.5	-0.3	0.3	-0.4	-2.5
Leg fat-free mass (right)	0.2	0.9	3.8	-0.7	-2.0	-0.8	-0.3	-0.6	0.7	0.4	0.0	0.5	-0.1	-1.9
Arm fat percentage (left)	0.2	0.9	3.6	-0.2	-1.3	-0.1	-0.6	-0.7	1.9	0.9	-0.5	1.2	-0.4	-1.1
Average weekly red wine intake	1.1	1.6	3.1	0.8	-1.7	-1.5	-0.8	-1.8	-1.3	1.1	-1.7	0.2	0.6	-1.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	4.4	0.4	-1.6	-0.1	-0.6	2.1	-0.2	-0.1	-0.2	0.7	-0.7	-1.3
Mood swings	0.2	0.3	0.8	0.3	0.3	0.9	-0.6	-0.3	0.7	0.6	-0.2	0.7	0.7	0.1
Loneliness, isolation	0.6	0.8	2.4	1.4	-0.4	0.0	-1.2	0.5	0.3	1.2	-0.6	0.7	1.6	-0.3
Long-standing illness, disability or infirmity	0.6	0.8	1.8	0.7	-1.2	-0.6	-0.8	-0.9	0.2	1.2	-1.3	0.6	1.0	-1.1
Ever had bowel cancer screening	0.9	1.1	6.4	-0.1	-0.5	0.2	-1.0	-0.5	2.5	0.9	-0.2	1.6	0.0	-0.2
Diabetes diagnosed by doctor	0.5	0.8	1.6	-0.9	0.7	0.9	1.2	0.5	0.6	-1.1	1.3	-0.8	-0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	0.8	-0.8	-0.5	-0.7	0.8	-0.7	0.9	-1.3	0.1	0.1	-0.7
Friendships satisfaction	1.3	1.7	6.1	0.6	0.6	2.5	-0.8	1.6	1.7	1.0	0.5	1.6	0.9	0.8
Qualifications: nursing, teaching	2.0	3.1	10.3	1.0	-1.8	-3.2	-1.3	-1.6	-2.3	0.5	-2.2	-0.3	0.9	-1.8
Commuting to job workplace: Walk	0.1	0.2	0.6	-0.2	-0.3	0.8	0.2	-0.5	0.7	0.1	-0.2	0.2	-0.3	-0.3
Eye problems/disorders: Cataract	1.2	1.4	5.9	-1.5	0.6	2.4	-0.1	1.0	1.8	-0.2	1.1	0.5	0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.3	0.4	0.2	-0.1	-0.9	1.5	1.2	1.0	0.1	1.5	1.1	0.5
Medication for cholesterol	0.5	0.8	1.9	0.4	-0.5	-0.5	-1.4	-1.2	0.1	1.2	-0.8	1.4	0.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.8	-0.0	-0.5	-0.9	-0.0	-0.1	0.2	0.3	-0.2	-0.1	0.2	-0.5
Back pain experienced in last month	0.6	0.9	2.2	0.0	-1.2	-0.5	-1.5	1.0	0.4	1.1	-0.6	1.1	0.9	-1.2
Mineral and other dietary supplements	1.0	1.4	3.4	-0.9	-0.0	1.7	1.3	0.3	-1.8	-1.5	1.0	-1.3	-1.2	-0.6
Breast cancer (self-reported)	0.3	0.4	1.7	0.3	-0.1	0.5	-0.6	-0.4	0.6	0.4	0.2	0.9	1.3	0.1
Asthma (self-reported)	1.0	1.9	5.0	2.2	-1.7	-0.6	-1.8	1.3	0.7	1.3	-1.5	1.3	0.3	-1.3
Osteoporosis (self-reported)	0.6	0.7	3.1	-1.3	-0.7	1.1	-0.0	0.4	1.7	0.0	0.5	0.4	-0.4	-0.7
Osteoarthritis (self-reported)	0.9	1.2	3.4	-1.2	0.3	-0.7	1.6	-0.8	-0.0	-1.2	0.4	-1.6	-1.8	-0.1
Medication: Aspirin	1.6	2.0	3.2	-1.2	1.7	1.6	1.5	1.8	0.7	-1.6	1.3	-1.2	-0.8	1.8
Medication: Gliclazide	0.2	0.2	0.8	0.0	0.2	0.5	-0.1	0.9	-0.4	0.6	0.4	-0.2	0.9	0.3
Illnesses of father: None of the above (group 1)	1.7	2.1	7.6	1.4	-0.9	0.5	-1.8	1.3	2.0	1.7	-0.4	2.8	0.2	-0.3
Smoking status: Current	0.5	0.7	3.6	0.1	1.0	1.2	0.3	1.9	0.6	0.2	0.8	0.1	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.4	0.4	-0.4	-0.4	-0.5	0.1	0.4	-0.2	0.1	0.9	0.4
Whole body water mass	0.3	1.4	5.9	-0.7	-2.4	-1.3	-0.4	-1.0	0.3	0.6	-0.3	0.4	-0.4	-2.4
Leg predicted mass (right)	0.2	0.9	3.6	-0.7	-1.9	-0.8	-0.4	-0.5	0.8	0.4	0.0	0.5	0.0	-1.9
Arm fat mass (left)	0.2	1.0	3.0	-0.5	-1.6	-0.4	-0.4	-0.9	1.7	0.7	-0.3	1.0	-0.6	-1.5
Number of self-reported non-cancer illnesses	1.0	1.8	3.6	0.7	-1.9	0.1	-1.4	1.0	1.9	1.6	-1.4	1.4	1.0	-1.4
Average weekly champagne plus white wine intake	1.3	1.8	4.5	-1.9	0.8	-1.0	1.7	0.4	-0.9	-2.0	1.1	-2.1	-0.8	0.3
Miserableness	0.6	1.1	4.6	0.4	-2.1	-0.3	-0.6	0.5	0.1	0.1	-0.9	0.5	-0.9	-2.1
Guilty feelings	1.1	1.6	3.9	-1.3	-0.4	-1.4	1.4	0.5	-1.8	-1.5	-0.3	-2.0	-1.3	-0.7
Wears glasses or contact lenses	0.7	0.8	2.3	-0.4	1.0	-1.5	0.9	-0.3	-1.0	-0.9	-0.2	-1.2	-0.4	1.0
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.4	0.7	0.8	0.4	-0.3	-0.2	0.3	-0.0	-0.5	0.9	0.7
Hearing aid user	0.5	0.5	1.3	-0.8	0.0	0.1	0.9	0.8	0.7	-1.1	1.1	-0.3	-0.9	0.1
Mother’s age at death	0.7	0.8	3.5	-1.1	-0.5	0.2	1.1	-0.5	0.5	-1.1	0.4	-0.7	-1.9	-0.8
Financial situation satisfaction	0.6	0.7	3.4	0.2	0.0	1.8	-0.3	0.9	1.4	0.7	-0.1	1.0	0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	0.2	-0.4	-0.8	-0.6	-1.0	0.8	0.7	-1.2	0.8	1.1	-0.4
Commuting to job workplace: Public transport	5.3	6.3	15.8	2.0	-3.1	-2.5	-2.5	-2.8	-0.6	2.7	-4.0	1.6	1.6	-2.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.7	0.9	0.0	0.3	-1.1	-1.1	-0.2	0.5	-0.9	1.0	0.9
Medication: Blood pressure	0.3	0.6	1.0	-0.4	-0.7	-0.1	0.8	1.0	-0.3	-1.0	0.3	-1.0	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	-0.6	-0.0	0.1	-0.2	-0.4	0.7	0.1	0.2	0.1	0.4	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.6	1.4	-0.2	-1.9	-1.5	-0.6	1.3	1.8	-1.0	1.7	1.3	0.3
High cholesterol (Self-reported)	1.8	3.2	8.0	-2.3	0.1	-0.3	2.8	0.1	-0.6	-2.5	1.1	-2.4	-2.8	-0.4
Medication: Bendroflumethiazide	0.8	1.3	3.0	1.4	-1.7	-1.1	-0.8	-0.5	-0.7	0.8	-1.6	-0.0	1.0	-1.6
Medication: Paracetamol	0.6	1.0	2.9	-0.2	-1.2	-0.7	-1.0	1.7	1.3	0.9	-0.7	0.9	0.1	-1.0
Medication: Lisinopril	0.5	0.6	1.6	-0.3	1.0	1.3	0.7	0.6	0.0	-1.1	0.8	-0.8	-0.5	0.9
Medication: Atorvastatin	3.1	3.9	13.0	-1.0	0.4	-2.1	2.1	-1.9	-3.6	-1.8	-0.6	-2.9	-1.9	-0.4
Illnesses of father: High blood pressure	0.5	0.6	1.6	0.5	-0.7	-1.1	-0.8	-0.1	-0.7	0.6	-1.3	-0.0	1.2	-0.8
Alcohol drinker status: Never	1.7	2.0	7.7	1.1	0.5	0.2	-1.7	-0.0	0.9	2.1	-0.1	2.0	2.8	1.0
Ever smoked	0.3	0.5	1.5	-0.4	-0.8	0.0	-0.8	-0.6	0.6	1.2	-0.9	0.5	-0.2	-0.6
Basal metabolic rate	0.2	1.3	5.3	-0.7	-2.3	-1.1	-0.4	-1.1	0.6	0.6	-0.3	0.5	-0.4	-2.3
Leg fat percentage (left)	0.2	0.6	2.4	0.2	-1.0	-0.0	-0.2	-0.7	1.5	0.6	-0.3	0.8	-0.7	-1.0
Arm fat-free mass (left)	0.2	1.1	4.5	-0.8	-2.0	-1.1	0.0	-1.0	0.2	0.3	-0.2	0.1	-0.8	-2.1
Number of operations (self-reported)	1.3	1.9	7.1	-0.4	-1.6	-2.7	0.1	-1.2	-1.8	0.3	-1.4	-0.8	-0.7	-1.9
Average weekly beer plus cider intake	0.3	0.4	1.9	0.5	-0.9	-0.1	-0.5	1.4	0.5	0.4	-0.1	0.6	-0.2	-0.9
Irritability	0.3	0.5	1.1	0.4	0.9	0.7	-0.2	1.0	0.8	0.2	0.7	0.4	0.6	0.9
Risk taking	0.8	1.2	3.6	-0.5	-1.9	-1.4	0.1	1.6	0.5	0.1	-0.4	0.3	-1.0	-1.8
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.6	-0.4	1.6	0.2	0.2	1.0	1.2	-0.1	1.0	0.2	0.7	1.6
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-0.2	-1.5	-1.5	-0.3	-0.7	-0.9	0.5	-1.2	-0.3	-0.5	-1.5
Age started oral contraceptive pill	0.7	0.9	4.1	0.5	-0.6	-1.3	0.3	-1.2	-2.0	-0.2	-0.6	-0.9	0.2	-0.9
Diastolic blood pressure, automated reading	0.4	1.3	5.7	0.6	-0.2	2.4	-0.7	1.3	1.9	0.2	1.2	1.2	-0.1	0.1
Ever depressed for a whole week	1.0	1.2	3.5	1.2	-1.9	-1.3	-1.0	0.6	0.1	0.8	-0.7	1.1	-0.0	-1.7
Unable to work because of sickness or disability	0.2	0.3	1.0	-0.4	-0.1	0.1	0.7	0.4	-0.3	-0.7	0.2	-1.0	-0.5	-0.5
Commuting to job workplace: Cycle	0.4	0.4	2.0	0.0	-0.8	-0.7	-0.5	-0.3	-0.3	0.6	-1.4	-0.0	0.3	-0.9
Myopia	0.6	0.8	2.7	0.1	1.4	1.6	0.1	1.0	0.6	-0.3	0.7	0.1	0.7	1.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	0.5	0.9	-0.6	0.1	-1.0	-0.3	0.4	0.2	0.3	-0.3	0.8
Cholesterol lowering medication	1.7	2.5	7.0	-1.2	0.5	-0.8	2.6	0.1	-1.2	-2.3	0.9	-2.6	-2.0	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	4.9	0.7	2.0	0.7	-0.1	1.4	1.4	-0.2	1.2	0.4	1.1	2.2
Pain experienced in last month	0.5	0.8	1.6	-0.8	1.2	0.2	1.2	-0.5	-0.5	-0.9	0.6	-1.3	-0.9	0.9
Supplements: Calcium	0.6	0.7	3.0	-0.1	-1.7	-0.7	-0.4	0.5	0.4	0.6	-1.0	0.4	-0.0	-1.5
Basal cell carcinoma (self-reported)	2.5	2.9	5.6	-2.3	2.4	-0.2	2.0	0.5	-0.5	-2.2	2.0	-2.0	-0.5	2.0
Heart attack/myocardial infarction (self-reported)	2.2	2.8	6.9	-2.0	1.4	0.8	2.1	1.6	-1.2	-2.2	1.7	-2.6	-0.6	0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	-0.0	-0.0	0.4	-0.6	1.1	0.6	0.4	-0.1	0.8	0.4	0.1
Heart disease (siblings)	0.6	0.7	1.9	-1.3	0.7	0.2	1.4	-0.8	-0.1	-0.7	1.1	-1.0	-0.6	0.4
Alcohol drinker status: Previous	1.2	1.3	4.2	1.4	1.9	0.5	-0.1	-0.0	-0.3	-0.3	0.7	-0.1	2.0	2.0
Pack years of smoking	0.3	0.5	1.0	-0.5	1.0	0.5	0.5	0.2	-0.9	-0.4	0.9	-0.4	0.5	1.0
Impedance of whole body	0.1	0.4	1.8	0.5	0.2	0.6	-0.7	0.1	-0.7	0.7	-1.3	0.3	0.4	0.2
Leg fat mass (left)	0.2	0.7	2.4	-0.4	-1.3	-0.2	-0.1	-0.8	1.6	0.4	0.0	0.6	-0.8	-1.2
Arm predicted mass (left)	0.2	1.1	4.0	-1.0	-1.8	-1.2	0.3	-0.7	0.2	0.0	0.2	-0.1	-1.1	-2.0