[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr1:22,080,775-25,768,937

Best TWAS P=6.38e-28 · Best GWAS P=1.73e-23 conditioned to 0.0112

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HMGCL	0.17	0.12	enet	24	0.13	1.6e-15	-6.5	-5.7	1.5e-08	-0.05	0.89	0.11	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HTR1D	0.11	0.07	enet	21	0.09	1.1e-10	6.2	-5.8	6.2e-09	-0.18	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	PITHD1	0.05	0.04	enet	8	0.05	7.9e-05	-8.2	8.6	1.0e-17	0.07	0.09	0.90	FALSE
4	GTEx	Adipose Subcutaneous	ZNF436	0.22	0.16	lasso	1	0.15	2.3e-12	5.4	5.4	7.1e-08	0.10	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	LUZP1	0.15	0.08	lasso	7	0.09	1.8e-05	-7.8	-8.5	1.8e-17	-0.29	0.28	0.04	FALSE
6	GTEx	Adrenal Gland	ZNF436	0.54	0.57	lasso	5	0.53	2.4e-22	5.4	5.4	6.6e-08	0.10	1.00	0.00	FALSE
7	GTEx	Artery Aorta	ZNF436	0.43	0.34	enet	17	0.39	1.3e-22	5.4	5.7	1.3e-08	0.13	1.00	0.00	FALSE
8	GTEx	Artery Tibial	PITHD1	0.09	0.10	lasso	4	0.10	5.3e-08	-8.4	8.6	5.6e-18	0.07	0.90	0.09	FALSE
9	GTEx	Artery Tibial	ZNF436	0.28	0.18	lasso	5	0.17	1.9e-13	5.1	5.3	1.1e-07	0.12	1.00	0.00	FALSE
10	GTEx	Artery Tibial	LUZP1	0.25	0.02	enet	51	0.11	3.4e-09	5.8	-7.2	5.5e-13	-0.09	0.66	0.01	FALSE
11	GTEx	Brain Cerebellum	HMGCL	0.30	0.06	lasso	3	0.08	1.7e-03	3.0	-5.8	5.0e-09	-0.08	0.07	0.68	FALSE
12	GTEx	Brain Cortex	HMGCL	0.22	0.09	enet	12	0.12	3.2e-04	-6.5	-7.3	2.8e-13	-0.08	0.08	0.65	FALSE
13	GTEx	Brain Frontal Cortex BA9	TCEA3	0.35	0.24	lasso	6	0.25	2.5e-07	1.9	-6.2	7.1e-10	-0.45	0.10	0.74	FALSE
14	GTEx	Brain Hypothalamus	TCEA3	0.33	0.18	enet	31	0.10	3.0e-03	-8.1	-8.8	1.2e-18	-0.47	0.04	0.49	FALSE
15	GTEx	Breast Mammary Tissue	ZNF436	0.25	0.14	enet	14	0.16	1.9e-08	5.4	5.2	2.2e-07	0.12	1.00	0.00	FALSE
16	GTEx	Cells Transformed fibroblasts	PITHD1	0.09	0.05	lasso	3	0.02	8.1e-03	-5.7	6.1	1.0e-09	0.08	0.18	0.68	FALSE
17	GTEx	Cells Transformed fibroblasts	LUZP1	0.09	0.09	lasso	4	0.08	2.8e-06	5.1	-5.1	2.8e-07	-0.14	0.93	0.00	FALSE
18	GTEx	Cells Transformed fibroblasts	TCEA3	0.33	0.19	lasso	4	0.22	2.6e-16	1.9	-5.2	1.6e-07	-0.51	0.92	0.08	FALSE
19	GTEx	Colon Transverse	ZNF436	0.56	0.40	lasso	3	0.43	2.9e-22	5.4	5.4	5.4e-08	0.11	1.00	0.00	FALSE
20	GTEx	Colon Transverse	LUZP1	0.23	0.02	lasso	4	0.09	3.4e-05	-5.7	-5.2	1.9e-07	-0.06	0.18	0.05	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	ZNF436	0.37	0.14	enet	13	0.23	6.2e-09	5.4	5.2	1.7e-07	0.17	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	ZNF436	0.17	0.09	lasso	4	0.12	1.6e-08	5.4	6.8	7.6e-12	0.15	0.96	0.01	FALSE
23	GTEx	Esophagus Muscularis	ZNF436	0.37	0.36	lasso	4	0.36	1.4e-22	5.4	5.3	1.4e-07	0.10	1.00	0.00	FALSE
24	GTEx	Esophagus Muscularis	LUZP1	0.17	0.15	enet	20	0.16	8.8e-10	6.2	-6.0	2.1e-09	-0.17	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	RP1-184J9.2	0.07	0.08	enet	6	0.05	6.1e-04	6.2	-7.2	8.5e-13	-0.22	0.60	0.17	FALSE
26	GTEx	Heart Left Ventricle	HMGCL	0.16	0.10	enet	19	0.11	2.1e-06	-5.7	-5.7	1.4e-08	-0.08	0.73	0.08	FALSE
27	GTEx	Heart Left Ventricle	FUCA1	0.16	0.20	lasso	3	0.21	3.2e-11	-8.3	8.5	1.3e-17	0.07	0.07	0.93	FALSE
28	GTEx	Heart Left Ventricle	TCEA3	0.26	0.06	enet	30	0.18	5.6e-10	-8.1	-11.0	6.4e-28	-0.28	0.85	0.07	TRUE
29	GTEx	Liver	HMGCL	0.27	0.04	lasso	4	0.02	8.2e-02	-8.3	5.3	1.1e-07	0.08	0.05	0.43	FALSE
30	GTEx	Liver	ZNF436	0.58	0.18	lasso	6	0.27	3.7e-08	5.4	5.5	2.9e-08	0.10	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	HMGCL	0.08	0.07	lasso	4	0.06	2.6e-06	-8.4	-8.3	1.4e-16	-0.07	0.52	0.48	FALSE
32	GTEx	Muscle Skeletal	ZNF436	0.17	0.12	lasso	2	0.09	2.3e-09	5.4	5.2	1.7e-07	0.10	1.00	0.00	FALSE
33	GTEx	Muscle Skeletal	LUZP1	0.07	0.08	enet	14	0.08	3.5e-08	-7.8	-7.7	1.9e-14	-0.25	0.96	0.00	FALSE
34	GTEx	Muscle Skeletal	ZBTB40	0.09	0.04	lasso	3	0.01	2.9e-02	5.9	6.4	1.6e-10	0.06	0.04	0.91	TRUE
35	GTEx	Muscle Skeletal	TCEA3	0.23	0.09	enet	24	0.17	9.6e-17	5.4	-8.2	1.9e-16	-0.07	1.00	0.00	FALSE
36	GTEx	Nerve Tibial	ZNF436	0.55	0.53	lasso	8	0.53	1.7e-43	5.4	5.3	9.1e-08	0.11	1.00	0.00	FALSE
37	GTEx	Ovary	ZNF436	0.42	0.05	lasso	4	0.18	3.2e-05	5.4	5.2	2.0e-07	0.14	0.58	0.05	FALSE
38	GTEx	Pancreas	ZNF436	0.71	0.50	lasso	7	0.48	5.8e-23	5.4	6.2	4.4e-10	0.14	1.00	0.00	FALSE
39	GTEx	Pituitary	ZNF436	0.66	0.53	lasso	5	0.45	1.0e-12	5.1	5.4	7.1e-08	0.14	1.00	0.00	FALSE
40	GTEx	Prostate	ZNF436	0.40	0.44	lasso	1	0.43	5.4e-12	5.4	5.4	7.1e-08	0.10	0.94	0.01	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	ZNF436	0.50	0.39	lasso	3	0.38	6.0e-22	5.4	5.5	5.2e-08	0.11	1.00	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	ZNF436	0.45	0.50	lasso	3	0.50	7.5e-48	5.4	5.5	3.2e-08	0.10	1.00	0.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	LUZP1	0.07	0.03	enet	13	0.07	1.2e-06	4.1	-6.1	1.1e-09	0.14	0.36	0.02	FALSE
44	GTEx	Skin Sun Exposed Lower leg	TCEA3	0.20	0.02	enet	23	0.07	3.2e-06	5.4	-6.7	2.0e-11	-0.16	0.96	0.00	FALSE
45	GTEx	Small Intestine Terminal Ileum	ZNF436	0.67	0.38	lasso	3	0.37	3.6e-09	5.4	5.1	3.1e-07	0.09	0.87	0.01	FALSE
46	GTEx	Stomach	ZNF436	0.57	0.45	lasso	2	0.44	6.0e-23	5.4	5.4	6.9e-08	0.10	1.00	0.00	FALSE
47	GTEx	Thyroid	HMGCL	0.10	0.10	lasso	1	0.09	2.5e-07	-8.4	-8.4	5.2e-17	-0.07	0.90	0.10	FALSE
48	GTEx	Thyroid	ZNF436	0.42	0.41	lasso	5	0.41	6.4e-34	5.4	5.4	6.9e-08	0.09	1.00	0.00	FALSE
49	GTEx	Thyroid	FUCA1	0.08	0.01	enet	13	0.01	4.8e-02	3.0	-5.4	8.0e-08	-0.06	0.03	0.78	FALSE
50	GTEx	Whole Blood	TCEB3	0.05	0.02	lasso	3	0.01	8.0e-02	-8.3	6.9	6.3e-12	0.05	0.09	0.57	FALSE
51	GTEx	Whole Blood	RP5-886K2.3	0.06	0.01	enet	22	0.00	1.1e-01	1.8	5.4	6.1e-08	0.05	0.07	0.46	FALSE
52	METSIM	Adipose	CLIC4	0.05	0.03	lasso	3	0.04	3.9e-06	-5.3	-6.0	1.6e-09	0.02	0.97	0.01	TRUE
53	METSIM	Adipose	IL22RA1	0.05	0.00	bslmm	417	0.01	1.3e-02	1.3	5.5	3.8e-08	0.09	0.06	0.08	FALSE
54	METSIM	Adipose	LUZP1	0.07	0.00	enet	30	0.01	1.1e-02	-7.8	-5.2	2.6e-07	-0.37	0.20	0.12	FALSE
55	METSIM	Adipose	SRSF10	0.05	0.02	bslmm	394	0.02	7.8e-04	-3.6	5.7	1.2e-08	0.14	0.58	0.09	FALSE
56	METSIM	Adipose	TCEB3	0.03	0.02	blup	340	0.01	2.4e-03	-6.2	6.1	1.2e-09	-0.02	0.10	0.87	FALSE
57	METSIM	Adipose	ZNF436	0.14	0.13	lasso	2	0.13	5.6e-19	5.4	6.0	1.7e-09	0.11	1.00	0.00	FALSE
58	NTR	Blood	CNR2	0.04	0.05	lasso	11	0.05	5.4e-15	-9.7	-9.7	2.2e-22	-0.08	0.03	0.97	FALSE
59	NTR	Blood	FUCA1	0.05	0.07	lasso	13	0.06	4.2e-20	-9.7	9.8	1.8e-22	0.08	0.03	0.97	TRUE
60	NTR	Blood	TCEB3	0.02	0.02	lasso	3	0.02	2.2e-06	-6.2	7.1	1.1e-12	0.07	0.56	0.44	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	HMGCL	0.15	0.22	enet	19	0.23	1.2e-28	-8.4	-7.9	2.3e-15	-0.07	0.94	0.06	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	HTR1D	0.10	0.10	lasso	4	0.12	1.3e-14	6.2	-7.8	5.8e-15	-0.19	1.00	0.00	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	SRSF10	0.10	0.05	enet	9	0.06	1.7e-08	4.4	-6.0	2.1e-09	-0.11	0.98	0.01	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	C1orf213	0.11	0.10	lasso	2	0.09	8.7e-12	6.9	-6.9	6.6e-12	-0.21	1.00	0.00	FALSE
65	YFS	Blood	FUCA1	0.17	0.29	bslmm	354	0.30	4.0e-102	-9.2	9.2	3.3e-20	0.09	0.42	0.58	FALSE
66	YFS	Blood	ID3	0.07	0.02	lasso	10	0.04	8.4e-13	-4.0	-5.6	2.0e-08	-0.78	0.01	0.99	TRUE
67	YFS	Blood	LUZP1	0.01	0.00	blup	407	0.01	1.8e-03	-6.5	-5.5	3.6e-08	-0.19	0.22	0.02	FALSE
68	YFS	Blood	TCEB3	0.06	0.07	lasso	2	0.07	2.2e-22	-6.2	6.2	5.4e-10	0.07	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUCA1	0.01	0.01	blup	35	0.01	1.6e-02	-8.4	-8.9	6.4e-19	-0.05	0.02	0.66	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCEA3	0.04	0.02	blup	55	0.04	7.3e-08	1.8	-5.6	1.8e-08	-0.14	0.78	0.19	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	C1orf213	0.13	0.04	lasso	3	0.01	1.1e-01	5.4	5.5	4.4e-08	0.08	0.04	0.04	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	HTR1D	0.10	0.07	enet	7	0.08	3.8e-05	5.9	-5.8	6.0e-09	-0.17	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	PNRC2	0.13	0.00	blup	33	0.07	2.2e-03	-3.6	-6.2	4.6e-10	-0.08	0.02	0.28	FALSE
74	The Cancer Genome Atlas	Glioblastoma Multiforme	C1orf128	0.10	0.03	enet	7	0.05	1.4e-02	6.5	8.3	6.8e-17	0.09	0.01	0.57	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TCEA3	0.03	0.00	blup	55	0.04	6.3e-05	6.9	-7.1	1.6e-12	-0.22	0.15	0.22	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PNRC2	0.05	0.01	enet	16	0.03	3.4e-04	3.0	-5.6	2.2e-08	0.00	0.01	0.74	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF436	0.08	0.06	lasso	2	0.05	3.1e-06	5.4	5.5	3.8e-08	0.10	0.97	0.00	FALSE
78	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TCEA3	0.12	0.04	blup	55	0.05	7.3e-04	3.3	-5.6	2.6e-08	-0.11	0.30	0.04	FALSE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF436	0.20	0.20	lasso	5	0.18	1.1e-10	5.3	6.0	2.0e-09	0.11	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	PNRC2	0.05	0.00	enet	8	0.03	1.5e-04	-6.5	-5.5	4.9e-08	-0.09	0.01	0.43	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB40	0.03	0.02	lasso	2	0.02	1.9e-03	-5.0	5.6	2.3e-08	0.01	0.02	0.88	FALSE
82	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF436	0.18	0.14	lasso	1	0.10	1.6e-05	5.4	5.4	7.1e-08	0.10	0.74	0.01	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf213	0.08	0.06	lasso	1	0.05	1.1e-06	5.3	5.3	9.4e-08	0.09	0.95	0.00	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF436	0.04	0.04	lasso	2	0.04	4.3e-05	5.4	5.4	6.0e-08	0.08	0.67	0.01	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ASAP3	0.03	0.02	blup	49	0.01	7.9e-03	10.0	-7.9	3.1e-15	-0.72	0.00	0.88	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMGCL	0.03	0.00	blup	41	0.01	1.1e-02	-3.6	-8.0	1.5e-15	-0.04	0.02	0.32	FALSE
87	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FUCA1	0.04	0.05	lasso	4	0.05	3.9e-04	-5.1	-5.2	1.6e-07	0.00	0.03	0.40	FALSE
88	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF436	0.08	0.00	blup	40	0.02	6.1e-02	4.0	7.2	4.4e-13	0.18	0.01	0.54	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASAP3	0.10	0.10	enet	11	0.11	1.1e-11	2.9	-5.6	2.6e-08	-0.48	0.99	0.01	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUCA1	0.09	0.04	blup	35	0.03	8.8e-04	-5.1	-5.5	2.9e-08	-0.01	0.62	0.10	FALSE
91	The Cancer Genome Atlas	Soft Tissue Sarcoma	TCEA3	0.07	0.02	blup	55	0.03	5.0e-03	6.5	-7.2	4.8e-13	-0.24	0.01	0.58	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF436	0.05	0.04	enet	6	0.05	1.1e-04	5.4	7.3	3.2e-13	0.15	0.24	0.11	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	TCEA3	0.08	0.03	lasso	5	0.06	1.3e-06	5.4	-6.7	3.0e-11	-0.12	0.90	0.06	FALSE