[Hub]/) : Traits : Blood Eosinophil Count :

chr1:25,807,095-29,145,188

Best TWAS P=4.9e-14 · Best GWAS P=3.12e-15 conditioned to 0.0227

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CD52 0.12 0.15 lasso 6 0.17 2.9e-20 6.6 -6.5 6.1e-11 0.09 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex NUDC 0.05 0.03 bslmm 257 0.03 7.4e-05 5.7 5.3 9.2e-08 -0.08 0.04 0.94 FALSE
3 CommonMind Brain Pre-frontal Cortex PIGV 0.04 0.03 bslmm 295 0.03 4.2e-05 5.7 -5.9 3.8e-09 0.06 0.72 0.27 FALSE
4 GTEx Adipose Subcutaneous PIGV 0.04 0.04 lasso 6 0.03 2.6e-03 5.8 -6.0 2.1e-09 0.07 0.55 0.21 FALSE
5 GTEx Artery Aorta PIGV 0.11 0.10 lasso 9 0.08 2.7e-05 5.6 -6.0 2.5e-09 0.07 0.69 0.26 FALSE
6 GTEx Brain Cerebellum CEP85 0.38 0.15 lasso 8 0.16 2.1e-05 5.0 5.3 8.7e-08 -0.05 0.22 0.28 FALSE
7 GTEx Brain Frontal Cortex BA9 CD52 0.31 0.03 enet 32 0.12 5.0e-04 6.6 -5.2 2.5e-07 0.11 0.04 0.80 FALSE
8 GTEx Breast Mammary Tissue PIGV 0.10 0.14 lasso 10 0.10 7.6e-06 5.7 -5.8 8.2e-09 0.07 0.72 0.26 FALSE
9 GTEx Breast Mammary Tissue (Female) PIGV 0.10 0.08 lasso 3 0.06 6.0e-03 5.7 -5.7 1.5e-08 0.06 0.28 0.13 FALSE
10 GTEx Cells Transformed fibroblasts PIGV 0.05 0.00 enet 10 0.03 4.3e-03 5.0 -5.2 2.2e-07 0.07 0.61 0.14 FALSE
11 GTEx Colon Transverse PIGV 0.17 0.15 lasso 2 0.14 3.4e-07 5.7 -5.7 1.5e-08 0.06 0.73 0.26 FALSE
12 GTEx Colon Transverse CNKSR1 0.14 0.00 enet 21 0.00 2.0e-01 4.7 -6.6 3.6e-11 0.13 0.09 0.34 FALSE
13 GTEx Esophagus Gastroesophageal Junction PIGV 0.13 0.02 lasso 10 0.01 1.2e-01 5.2 -5.4 7.5e-08 0.04 0.18 0.13 FALSE
14 GTEx Esophagus Mucosa PIGV 0.16 0.15 lasso 6 0.14 7.0e-10 5.5 -5.5 4.1e-08 0.06 0.78 0.22 FALSE
15 GTEx Esophagus Muscularis PIGV 0.09 0.07 enet 25 0.13 3.4e-08 5.7 -6.6 5.4e-11 0.09 0.76 0.24 FALSE
16 GTEx Esophagus Muscularis THEMIS2 0.10 0.02 lasso 4 0.03 7.1e-03 5.5 6.3 2.6e-10 -0.02 0.33 0.03 FALSE
17 GTEx Heart Left Ventricle CD52 0.15 0.10 lasso 5 0.10 6.0e-06 6.4 -5.6 2.0e-08 0.09 0.14 0.84 FALSE
18 GTEx Lung CD52 0.10 0.04 lasso 4 0.06 3.6e-05 5.5 -6.0 1.5e-09 0.07 0.04 0.96 FALSE
19 GTEx Muscle Skeletal PIGV 0.07 0.01 enet 12 0.02 2.1e-03 5.6 -5.4 5.5e-08 0.04 0.42 0.17 FALSE
20 GTEx Pituitary PIGV 0.25 0.12 lasso 10 0.02 8.8e-02 5.6 -5.7 9.6e-09 0.06 0.17 0.11 FALSE
21 GTEx Prostate RP1-50O24.6 0.15 0.02 lasso 9 0.02 1.1e-01 5.6 5.6 1.8e-08 -0.06 0.04 0.49 FALSE
22 GTEx Skin Sun Exposed Lower leg PIGV 0.05 0.07 lasso 2 0.06 5.0e-06 5.5 -5.5 4.2e-08 0.06 0.71 0.27 FALSE
23 GTEx Stomach PIGV 0.09 0.14 lasso 1 0.12 1.5e-06 5.7 -5.7 1.5e-08 0.06 0.69 0.24 FALSE
24 GTEx Testis UBXN11 0.33 0.30 lasso 11 0.29 2.6e-13 5.8 -6.0 1.4e-09 0.10 0.35 0.65 FALSE
25 GTEx Thyroid PIGV 0.14 0.12 lasso 7 0.10 2.7e-08 5.2 -5.7 1.2e-08 0.04 0.72 0.28 FALSE
26 GTEx Thyroid ZDHHC18 0.11 0.10 lasso 4 0.13 4.2e-10 5.0 5.6 1.8e-08 -0.08 0.21 0.79 FALSE
27 GTEx Whole Blood CEP85 0.07 0.01 enet 17 0.02 1.3e-02 5.8 7.3 2.9e-13 -0.10 0.16 0.42 TRUE
28 GTEx Whole Blood CD52 0.12 0.05 lasso 6 0.06 5.9e-06 5.6 -5.5 3.2e-08 0.10 0.30 0.69 FALSE
29 GTEx Whole Blood ZDHHC18 0.04 0.02 lasso 1 0.01 5.7e-02 5.7 5.7 1.4e-08 -0.06 0.05 0.89 FALSE
30 METSIM Adipose HMGN2 0.10 0.02 blup 367 0.05 4.9e-08 2.3 6.4 1.8e-10 -0.08 0.93 0.02 FALSE
31 METSIM Adipose PIGV 0.03 0.02 enet 25 0.04 2.8e-06 -2.0 -5.2 2.3e-07 0.08 0.52 0.17 FALSE
32 METSIM Adipose ZDHHC18 0.04 0.03 lasso 2 0.04 3.8e-06 5.2 6.3 2.9e-10 -0.06 0.06 0.94 FALSE
33 METSIM Adipose ZNF683 0.04 0.00 bslmm 383 0.01 3.6e-02 4.5 -5.8 7.6e-09 0.01 0.12 0.43 FALSE
34 NTR Blood ARID1A 0.03 0.03 enet 20 0.03 7.8e-11 5.7 -6.5 8.5e-11 0.07 0.76 0.24 FALSE
35 NTR Blood C1orf38 0.08 0.06 enet 11 0.07 2.1e-21 5.6 6.2 5.2e-10 -0.01 1.00 0.00 FALSE
36 NTR Blood EYA3 0.14 0.06 bslmm 271 0.06 3.1e-18 -4.4 -6.0 2.7e-09 0.39 1.00 0.00 FALSE
37 NTR Blood RPA2 0.09 0.09 lasso 4 0.09 9.0e-27 -6.1 6.1 9.3e-10 -0.08 0.99 0.01 FALSE
38 NTR Blood ZDHHC18 0.01 0.00 bslmm 285 0.01 5.7e-03 5.0 5.5 4.9e-08 -0.08 0.22 0.47 FALSE
39 ROSMAP Brain Pre-frontal Cortex CD52 0.15 0.19 enet 23 0.20 3.4e-25 5.8 -5.6 2.7e-08 0.09 0.65 0.35 FALSE
40 YFS Blood ZDHHC18 0.08 0.11 bslmm 286 0.11 2.1e-33 5.0 5.3 1.1e-07 -0.09 0.59 0.40 FALSE
41 The Cancer Genome Atlas Breast Invasive Carcinoma AIM1L 0.01 0.01 lasso 2 0.01 1.8e-03 5.7 5.7 1.0e-08 -0.10 0.02 0.50 FALSE
42 The Cancer Genome Atlas Breast Invasive Carcinoma C1orf38 0.05 0.03 lasso 5 0.04 4.5e-08 3.9 5.2 1.5e-07 0.05 0.12 0.88 FALSE
43 The Cancer Genome Atlas Breast Invasive Carcinoma PIGV 0.02 0.02 lasso 10 0.03 1.3e-06 5.0 -5.8 6.9e-09 0.08 0.01 0.99 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma TRIM63 0.15 0.16 lasso 2 0.16 2.3e-32 -5.3 -5.3 1.1e-07 0.09 0.01 0.99 FALSE
45 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TRIM63 0.14 0.15 lasso 1 0.14 2.2e-07 -5.3 -5.3 1.3e-07 0.09 0.01 0.99 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma PIGV 0.05 0.03 blup 19 0.02 2.0e-02 4.9 -6.4 2.0e-10 0.10 0.01 0.55 FALSE
47 The Cancer Genome Atlas Colon Adenocarcinoma TRIM63 0.08 0.10 lasso 4 0.10 3.7e-06 -5.3 -5.6 2.3e-08 0.08 0.01 0.99 FALSE
48 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1orf38 0.03 0.01 blup 35 0.02 1.7e-03 -6.3 6.2 4.6e-10 -0.08 0.01 0.97 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GRRP1 0.11 0.02 blup 52 0.03 8.8e-05 2.7 -5.8 5.7e-09 0.04 0.02 0.27 FALSE
50 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C1orf38 0.04 0.02 blup 35 0.03 4.2e-04 5.5 5.4 6.8e-08 0.00 0.05 0.45 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GPN2 0.03 0.01 lasso 9 0.02 3.2e-03 5.6 5.6 2.3e-08 -0.06 0.01 0.95 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PIGV 0.03 0.05 lasso 7 0.04 4.2e-05 5.7 -5.8 5.4e-09 0.07 0.01 0.99 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIM63 0.11 0.11 enet 4 0.12 9.0e-14 -5.3 -5.4 8.3e-08 0.08 0.01 0.99 FALSE
54 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AIM1L 0.07 0.03 blup 73 0.08 3.9e-05 5.4 6.0 1.5e-09 -0.04 0.02 0.92 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma CD52 0.03 0.02 enet 8 0.02 7.3e-04 5.8 -5.5 4.6e-08 0.04 0.02 0.93 FALSE
56 The Cancer Genome Atlas Brain Lower Grade Glioma TRIM63 0.29 0.33 enet 20 0.33 2.5e-38 -5.3 -5.3 8.7e-08 0.07 0.01 0.99 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma C1orf38 0.04 0.02 blup 35 0.03 1.0e-04 -6.3 5.7 1.2e-08 -0.01 0.01 0.96 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma CD52 0.04 0.04 lasso 2 0.04 3.3e-05 5.7 -5.7 1.2e-08 0.10 0.10 0.65 FALSE
59 The Cancer Genome Atlas Lung Adenocarcinoma TRIM63 0.14 0.20 enet 7 0.21 9.4e-24 -5.2 -5.5 2.9e-08 0.07 0.01 0.99 FALSE
60 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CD52 0.02 0.01 blup 67 0.01 1.1e-02 6.6 -6.7 1.8e-11 0.08 0.01 0.89 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TRIM63 0.16 0.11 lasso 1 0.10 2.0e-11 -5.3 -5.3 9.3e-08 0.09 0.01 0.99 FALSE
62 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TRIM63 0.14 0.18 lasso 7 0.15 3.0e-10 -5.3 -5.5 3.4e-08 0.08 0.01 0.99 FALSE
63 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPA2 0.11 0.03 blup 46 0.07 1.3e-03 -3.4 -6.5 1.0e-10 0.00 0.01 0.63 TRUE
64 The Cancer Genome Atlas Prostate Adenocarcinoma FAM46B 0.04 0.00 blup 23 0.01 3.5e-02 -3.7 -7.2 5.0e-13 -0.02 0.00 0.25 TRUE
65 The Cancer Genome Atlas Thyroid Carcinoma PTAFR 0.07 0.02 lasso 2 0.02 3.4e-03 -7.5 7.5 4.9e-14 -0.78 0.01 0.78 TRUE
66 The Cancer Genome Atlas Thyroid Carcinoma SNHG12 0.08 0.02 lasso 3 0.02 1.1e-02 -4.1 5.9 3.0e-09 -0.55 0.01 0.84 FALSE
67 The Cancer Genome Atlas Thyroid Carcinoma TRIM63 0.18 0.26 enet 7 0.26 3.0e-25 -5.2 -5.2 2.1e-07 0.08 0.01 0.99 FALSE
68 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TRIM63 0.19 0.07 blup 33 0.14 1.3e-04 -5.3 -5.2 1.8e-07 0.06 0.01 0.98 FALSE