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chr1:25,807,095-29,145,188

Best TWAS P=4.9e-14 · Best GWAS P=3.12e-15 conditioned to 0.0227

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CD52	0.12	0.15	lasso	6	0.17	2.9e-20	6.6	-6.5	6.1e-11	0.09	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUDC	0.05	0.03	bslmm	257	0.03	7.4e-05	5.7	5.3	9.2e-08	-0.08	0.04	0.94	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PIGV	0.04	0.03	bslmm	295	0.03	4.2e-05	5.7	-5.9	3.8e-09	0.06	0.72	0.27	FALSE
4	GTEx	Adipose Subcutaneous	PIGV	0.04	0.04	lasso	6	0.03	2.6e-03	5.8	-6.0	2.1e-09	0.07	0.55	0.21	FALSE
5	GTEx	Artery Aorta	PIGV	0.11	0.10	lasso	9	0.08	2.7e-05	5.6	-6.0	2.5e-09	0.07	0.69	0.26	FALSE
6	GTEx	Brain Cerebellum	CEP85	0.38	0.15	lasso	8	0.16	2.1e-05	5.0	5.3	8.7e-08	-0.05	0.22	0.28	FALSE
7	GTEx	Brain Frontal Cortex BA9	CD52	0.31	0.03	enet	32	0.12	5.0e-04	6.6	-5.2	2.5e-07	0.11	0.04	0.80	FALSE
8	GTEx	Breast Mammary Tissue	PIGV	0.10	0.14	lasso	10	0.10	7.6e-06	5.7	-5.8	8.2e-09	0.07	0.72	0.26	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PIGV	0.10	0.08	lasso	3	0.06	6.0e-03	5.7	-5.7	1.5e-08	0.06	0.28	0.13	FALSE
10	GTEx	Cells Transformed fibroblasts	PIGV	0.05	0.00	enet	10	0.03	4.3e-03	5.0	-5.2	2.2e-07	0.07	0.61	0.14	FALSE
11	GTEx	Colon Transverse	PIGV	0.17	0.15	lasso	2	0.14	3.4e-07	5.7	-5.7	1.5e-08	0.06	0.73	0.26	FALSE
12	GTEx	Colon Transverse	CNKSR1	0.14	0.00	enet	21	0.00	2.0e-01	4.7	-6.6	3.6e-11	0.13	0.09	0.34	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	PIGV	0.13	0.02	lasso	10	0.01	1.2e-01	5.2	-5.4	7.5e-08	0.04	0.18	0.13	FALSE
14	GTEx	Esophagus Mucosa	PIGV	0.16	0.15	lasso	6	0.14	7.0e-10	5.5	-5.5	4.1e-08	0.06	0.78	0.22	FALSE
15	GTEx	Esophagus Muscularis	PIGV	0.09	0.07	enet	25	0.13	3.4e-08	5.7	-6.6	5.4e-11	0.09	0.76	0.24	FALSE
16	GTEx	Esophagus Muscularis	THEMIS2	0.10	0.02	lasso	4	0.03	7.1e-03	5.5	6.3	2.6e-10	-0.02	0.33	0.03	FALSE
17	GTEx	Heart Left Ventricle	CD52	0.15	0.10	lasso	5	0.10	6.0e-06	6.4	-5.6	2.0e-08	0.09	0.14	0.84	FALSE
18	GTEx	Lung	CD52	0.10	0.04	lasso	4	0.06	3.6e-05	5.5	-6.0	1.5e-09	0.07	0.04	0.96	FALSE
19	GTEx	Muscle Skeletal	PIGV	0.07	0.01	enet	12	0.02	2.1e-03	5.6	-5.4	5.5e-08	0.04	0.42	0.17	FALSE
20	GTEx	Pituitary	PIGV	0.25	0.12	lasso	10	0.02	8.8e-02	5.6	-5.7	9.6e-09	0.06	0.17	0.11	FALSE
21	GTEx	Prostate	RP1-50O24.6	0.15	0.02	lasso	9	0.02	1.1e-01	5.6	5.6	1.8e-08	-0.06	0.04	0.49	FALSE
22	GTEx	Skin Sun Exposed Lower leg	PIGV	0.05	0.07	lasso	2	0.06	5.0e-06	5.5	-5.5	4.2e-08	0.06	0.71	0.27	FALSE
23	GTEx	Stomach	PIGV	0.09	0.14	lasso	1	0.12	1.5e-06	5.7	-5.7	1.5e-08	0.06	0.69	0.24	FALSE
24	GTEx	Testis	UBXN11	0.33	0.30	lasso	11	0.29	2.6e-13	5.8	-6.0	1.4e-09	0.10	0.35	0.65	FALSE
25	GTEx	Thyroid	PIGV	0.14	0.12	lasso	7	0.10	2.7e-08	5.2	-5.7	1.2e-08	0.04	0.72	0.28	FALSE
26	GTEx	Thyroid	ZDHHC18	0.11	0.10	lasso	4	0.13	4.2e-10	5.0	5.6	1.8e-08	-0.08	0.21	0.79	FALSE
27	GTEx	Whole Blood	CEP85	0.07	0.01	enet	17	0.02	1.3e-02	5.8	7.3	2.9e-13	-0.10	0.16	0.42	TRUE
28	GTEx	Whole Blood	CD52	0.12	0.05	lasso	6	0.06	5.9e-06	5.6	-5.5	3.2e-08	0.10	0.30	0.69	FALSE
29	GTEx	Whole Blood	ZDHHC18	0.04	0.02	lasso	1	0.01	5.7e-02	5.7	5.7	1.4e-08	-0.06	0.05	0.89	FALSE
30	METSIM	Adipose	HMGN2	0.10	0.02	blup	367	0.05	4.9e-08	2.3	6.4	1.8e-10	-0.08	0.93	0.02	FALSE
31	METSIM	Adipose	PIGV	0.03	0.02	enet	25	0.04	2.8e-06	-2.0	-5.2	2.3e-07	0.08	0.52	0.17	FALSE
32	METSIM	Adipose	ZDHHC18	0.04	0.03	lasso	2	0.04	3.8e-06	5.2	6.3	2.9e-10	-0.06	0.06	0.94	FALSE
33	METSIM	Adipose	ZNF683	0.04	0.00	bslmm	383	0.01	3.6e-02	4.5	-5.8	7.6e-09	0.01	0.12	0.43	FALSE
34	NTR	Blood	ARID1A	0.03	0.03	enet	20	0.03	7.8e-11	5.7	-6.5	8.5e-11	0.07	0.76	0.24	FALSE
35	NTR	Blood	C1orf38	0.08	0.06	enet	11	0.07	2.1e-21	5.6	6.2	5.2e-10	-0.01	1.00	0.00	FALSE
36	NTR	Blood	EYA3	0.14	0.06	bslmm	271	0.06	3.1e-18	-4.4	-6.0	2.7e-09	0.39	1.00	0.00	FALSE
37	NTR	Blood	RPA2	0.09	0.09	lasso	4	0.09	9.0e-27	-6.1	6.1	9.3e-10	-0.08	0.99	0.01	FALSE
38	NTR	Blood	ZDHHC18	0.01	0.00	bslmm	285	0.01	5.7e-03	5.0	5.5	4.9e-08	-0.08	0.22	0.47	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	CD52	0.15	0.19	enet	23	0.20	3.4e-25	5.8	-5.6	2.7e-08	0.09	0.65	0.35	FALSE
40	YFS	Blood	ZDHHC18	0.08	0.11	bslmm	286	0.11	2.1e-33	5.0	5.3	1.1e-07	-0.09	0.59	0.40	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	AIM1L	0.01	0.01	lasso	2	0.01	1.8e-03	5.7	5.7	1.0e-08	-0.10	0.02	0.50	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf38	0.05	0.03	lasso	5	0.04	4.5e-08	3.9	5.2	1.5e-07	0.05	0.12	0.88	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	PIGV	0.02	0.02	lasso	10	0.03	1.3e-06	5.0	-5.8	6.9e-09	0.08	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	-5.3	-5.3	1.1e-07	0.09	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	-5.3	-5.3	1.3e-07	0.09	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	PIGV	0.05	0.03	blup	19	0.02	2.0e-02	4.9	-6.4	2.0e-10	0.10	0.01	0.55	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	-5.3	-5.6	2.3e-08	0.08	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf38	0.03	0.01	blup	35	0.02	1.7e-03	-6.3	6.2	4.6e-10	-0.08	0.01	0.97	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRRP1	0.11	0.02	blup	52	0.03	8.8e-05	2.7	-5.8	5.7e-09	0.04	0.02	0.27	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1orf38	0.04	0.02	blup	35	0.03	4.2e-04	5.5	5.4	6.8e-08	0.00	0.05	0.45	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPN2	0.03	0.01	lasso	9	0.02	3.2e-03	5.6	5.6	2.3e-08	-0.06	0.01	0.95	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIGV	0.03	0.05	lasso	7	0.04	4.2e-05	5.7	-5.8	5.4e-09	0.07	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	-5.3	-5.4	8.3e-08	0.08	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AIM1L	0.07	0.03	blup	73	0.08	3.9e-05	5.4	6.0	1.5e-09	-0.04	0.02	0.92	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD52	0.03	0.02	enet	8	0.02	7.3e-04	5.8	-5.5	4.6e-08	0.04	0.02	0.93	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	-5.3	-5.3	8.7e-08	0.07	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf38	0.04	0.02	blup	35	0.03	1.0e-04	-6.3	5.7	1.2e-08	-0.01	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	CD52	0.04	0.04	lasso	2	0.04	3.3e-05	5.7	-5.7	1.2e-08	0.10	0.10	0.65	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	-5.2	-5.5	2.9e-08	0.07	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CD52	0.02	0.01	blup	67	0.01	1.1e-02	6.6	-6.7	1.8e-11	0.08	0.01	0.89	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	-5.3	-5.3	9.3e-08	0.09	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	-5.3	-5.5	3.4e-08	0.08	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPA2	0.11	0.03	blup	46	0.07	1.3e-03	-3.4	-6.5	1.0e-10	0.00	0.01	0.63	TRUE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM46B	0.04	0.00	blup	23	0.01	3.5e-02	-3.7	-7.2	5.0e-13	-0.02	0.00	0.25	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	PTAFR	0.07	0.02	lasso	2	0.02	3.4e-03	-7.5	7.5	4.9e-14	-0.78	0.01	0.78	TRUE
66	The Cancer Genome Atlas	Thyroid Carcinoma	SNHG12	0.08	0.02	lasso	3	0.02	1.1e-02	-4.1	5.9	3.0e-09	-0.55	0.01	0.84	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	-5.2	-5.2	2.1e-07	0.08	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	-5.3	-5.2	1.8e-07	0.06	0.01	0.98	FALSE